Risteys · M13

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M71.4 Cause of death: ICD-10 — M71.4 2 out of 7 registries used, show all original rules.	74
4. Check minimum number of events None	74
5. Include endpoints None	74
6. Filter based on genotype QC (FinnGen only)	74

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	441	216	224
Only index persons	420	209	211
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	54.38	54.77	53.91
Only index persons	53.77	54.21	53.33

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	74	40	34
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	52.16	49.86	54.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
62: Matched controls
618

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M71.4

ICD-10 Finland

Calcium deposit in bursa

+∞

89.0

NBG10

NOMESCO Finland

Acromioplastia

103.6

8.6

NHM20

NOMESCO Finland

Excision of synovial ganglion of ankle or foot

90.5

7.6

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

25.9

6.9

NCM20

NOMESCO Finland

Excision of synovial ganglion of elbow or forearm

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

134

2.75

4.02

4.8

4.5

—

(3019060) Gas panel - Arterial blood

3.39

3.13

4.3

3.6

—

(3004809) Band form neutrophils/100 leukocytes in Blood

10.59

3.02

5.0

2.8

1.4

1.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.74

2.55

2.0

1.6

—

(3019198) Lymphocytes [#/volume] in Blood

266

2.10

2.48

8.5

5.3

1.9

1.8

e9/l

0.19

243

(3006315) Basophils [#/volume] in Blood

260

2.06

2.38

7.6

5.4

0.1

0.0

e9/l

2.25

229

(40768804) Tissue Pathology biopsy report

242

2.06

2.37

1.8

2.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

216

2.06

2.36

2.0

1.6

93.0

93.8

pmol/l

0.04

113

(3001604) Monocytes [#/volume] in Blood

259

1.96

2.11

7.2

5.3

0.6

e9/l

0.52

227

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

5.27

2.10

1.2

—

(3007566) Smooth muscle Ab [Titer] in Serum

4.79

1.97

1.4

1.3

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

4.79

1.97

1.2

1.6

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

184

1.95

2.9

1.9

60.6

57.8

u/l

0.08

169

(42870588) Differential panel, method unspecified - Blood

169

1.94

1.88

7.4

5.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.74

1.88

1.2

2.0

—

(40768797) Stomach Pathology biopsy report

2.25

1.85

1.3

1.2

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.52

1.80

2.9

1.9

117.5

144.8

ng/l

0.21

(3019225) pH of Specimen

2.60

1.76

11.3

4.0

—

(3042936) Bacteria identified in Isolate by Culture

2.16

1.69

2.0

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

125

1.95

1.66

3.4

2.0

—

(3022313) Gas panel - Capillary blood

3.17

1.61

2.7

2.6

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.41

1.54

5.7

3.0

0.4

0.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.02

1.54

2.3

2.1

—

(3044640) Blood type and Crossmatch panel - Blood

175

1.75

1.39

3.4

2.0

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.08

1.38

1.2

2.0

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

3.08

1.38

1.2

2.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

262

1.64

1.24

5.8

3.8

—

(4094501)

2.74

1.23

1.0

1.1

—

(3017181) Myelocytes/100 leukocytes in Blood

2.16

1.23

5.8

3.0

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

320

1.63

1.23

9.5

11.5

4.5

4.2

e9/l

0.28

283

(3032080) INR in Blood by Coagulation assay

227

1.63

1.19

6.1

9.1

1.2

1.3

inr

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.47

1.16

9.7

7.0

—

(40768443) Skin Pathology biopsy report

2.39

1.14

1.0

1.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.48

1.11

2.2

2.0

—

(3009508) Creatinine [Moles/volume] in Urine

177

1.62

1.08

2.4

2.9

7.0

7.5

mmol/l

0.28

145

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

593

1.79

0.91

4.5

3.9

1.2

mmol/l

0.07

551

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

1.81

0.88

3.9

2.3

19.5

22.1

0.33

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.83

0.86

1.6

1.5

459.0

371.8

nmol/l

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.95

0.84

5.2

3.4

99.3

131.9

g/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

160

1.53

0.83

3.1

2.5

3371.9

1074.7

ng/l

0.35

141

(3012516) Albumin [Mass/volume] in Urine

169

1.52

0.83

2.3

3.0

93.8

87.3

mg/l

0.02

107

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

441

1.50

0.82

3.6

14.5

15.0

pmol/l

0.65

394

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.72

0.77

2.3

2.1

1.7

1.2

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

600

1.68

0.69

24.7

12.4

32.6

22.9

mg/l

0.92

460

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

279

1.40

0.69

11.6

6.7

1.2

mmol/l

0.50

242

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

194

1.44

0.68

5.1

2.6

40.5

29.9

u/l

1.31

188

(3022621) pH of Urine by Test strip

1.84

0.67

5.4

2.5

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.84

0.67

3.2

2.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.78

0.65

8.6

5.2

26.8

25.4

mmol/l

—

(3012544) pH of Venous blood

1.67

0.64

6.0

3.4

—

(4034850)

0.00

0.61

0.0

11.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.54

0.59

4.3

3.3

—

(3013512) EKG study

162

1.41

0.59

6.0

3.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.52

0.58

2.2

1.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

182

1.38

0.56

3.2

3.9

12.5

14.6

mg/mmol

0.06

110

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

229

1.36

0.56

4.2

3.3

35.9

38.2

ng/l

0.05

155

(3000991) Gas panel - Venous blood

1.54

0.53

8.7

6.0

—

(3000492) Spirometry study

1.61

0.50

1.3

1.7

—

(3002032) Base excess in Venous blood by calculation

1.58

0.50

6.0

3.6

1.9

2.9

mmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

237

0.73

0.49

5.2

3.6

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

311

1.31

0.48

8.8

6.2

9.9

umol/l

0.01

294

(3000850) Epithelial cells [#/volume] in Urine

122

1.40

0.47

2.4

2.5

1.4

6.2

e6/l

4.62

102

(3026008) Bacteria identified in Urine by Culture

159

1.35

0.47

2.5

2.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

343

1.29

0.45

3.9

3.0

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

4.2

—

35.1

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

0.00

0.41

0.0

4.2

—

52.4

—

(1002224) Polysomnography panel

0.00

0.41

0.0

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.42

0.41

1.9

1.5

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

629

1.46

0.41

24.8

13.5

139.5

139.9

mmol/l

0.79

610

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.40

0.0

1.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

397

1.27

0.39

4.9

2.6

71.3

48.1

u/l

0.53

369

(3000494) Fungus identified in Specimen by Culture

1.32

0.38

1.9

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

176

0.75

0.37

5.2

3.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.47

0.36

2.0

1.5

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

631

1.42

0.31

25.0

13.6

4.0

mmol/l

0.25

612

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

581

1.28

0.28

6.9

5.3

38.9

39.6

mmol/mol

0.35

545

(3022145) Colonoscopy Study observation

1.26

0.28

1.1

1.2

—

(3044889) 12 lead EKG panel

438

1.20

0.26

4.0

3.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

207

0.83

0.23

3.1

2.8

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.21

0.0

2.0

—

234.3

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.8

—

4.9

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.5

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.6

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.21

0.0

5.7

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.6

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.0

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.21

0.0

1.0

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.21

0.0

2.2

—

96.2

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.20

0.0

3.6

—

71.6

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.18

0.18

1.3

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.14

0.18

1.9

1.6

—

(36304419) Bacteria [Presence] in Urine

161

0.84

0.17

2.6

2.5

—

(3002256) Pathology report gross observation

1.16

0.17

1.5

1.2

—

(1761868) Lipid panel - Serum or Plasma

232

0.87

0.16

2.1

3.0

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

651

1.31

0.15

24.9

14.7

84.8

77.5

umol/l

0.29

651

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

651

1.31

0.15

15.5

9.8

25.8

25.6

u/l

0.03

623

(40761511) CBC panel - Blood by Automated count

642

1.26

0.14

19.9

12.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

409

1.12

0.14

6.3

3.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

104

1.18

0.13

2.3

1.8

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

473

1.11

0.10

11.6

7.0

80.0

77.1

u/l

0.30

439

(3011397) Hemoglobin [Presence] in Urine by Test strip

126

1.14

0.10

2.4

2.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.07

0.09

1.0

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.14

0.09

1.0

1.3

—

(3007461) Platelets [#/volume] in Blood

679

1.24

0.08

33.3

18.7

252.4

247.5

e9/l

0.22

663

(3024731) MCV [Entitic volume]

680

1.22

0.08

32.9

18.7

91.4

91.1

0.17

668

(4035726)

0.79

0.08

1.0

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.12

0.08

1.9

1.7

—

(21494755) Public health laboratory ask at order entry panel

0.83

0.08

1.7

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

122

1.08

0.03

11.7

5.6

—

(40758558) Short blood count panel - Blood

147

0.94

0.01

3.9

7.9

—

(3018095) Leukocytes [#/volume] in Urine

217

0.95

0.01

3.8

3.2

73.5

75.6

e6/l

0.01

151

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

114

1.06

0.01

1.4

—

(3021589) Normoblasts [#/volume] in Blood

264

1.04

0.00

9.2

11.9

0.0

e9/l

0.11

217

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

212

0.99

0.00

5.5

4.8

1.3

3.5

ug/l

0.81

186

(3003694) ABO and Rh group [Type] in Blood

163

0.98

0.00

2.1

1.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

585

1.04

0.00

18.7

11.6

79.0

81.1

ml/min/173m2

0.31

475

(3009542) Hematocrit [Volume Fraction] of Blood

554

0.97

0.00

18.7

13.1

39.0

40.0

0.28

401

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

176

1.03

0.00

5.0

4.1

25.2

22.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.89

0.00

1.2

1.6

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.1

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

2.0

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

2.3

—

(4281824)

0.00

0.0

1.0

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

18.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.01

0.00

1.2

1.4

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

12.2

—

974.2

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

3.7

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3026361) Erythrocytes [#/volume] in Blood

681

1.20

0.00

33.0

18.7

4.5

e12/l

0.14

663

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.4

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

19.8

—

1809.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

0.0

1.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

15.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.2

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.3

—

5.7

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.0

1.1

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

3.3

—

(3000963) Hemoglobin [Mass/volume] in Blood

681

1.20

0.00

33.1

18.8

133.8

135.7

g/l

0.53

668

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.3

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

8.4

—

(3010813) Leukocytes [#/volume] in Blood

681

1.20

0.00

33.0

18.8

7.1

6.5

e9/l

1.06

663

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.2

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

245.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.1

—

184.4

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3035941) MCH [Entitic mass]

681

1.20

0.00

32.9

18.6

30.3

0.05

669

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.92

0.00

2.5

1.5

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.2

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

3.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.84

0.00

1.2

1.7

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.3

—

33.4

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.2

—

10.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_CALCBURS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_CALCBURS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_CALCBURS – Calcium deposit in bursa

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	M13_CALCBURS
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M714
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M714
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Calcium deposit in bursa

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints