hypersensitivity vasculitis: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
182 |
4. Check minimum number of eventsNone |
182 |
5. Include endpointsNone |
182 |
6. Filter based on genotype QC (FinnGen only) |
177 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M31
- Name in latin
- Angi(i)tis hypersensitivitatis
Similar endpoints
↥List of similar endpoints to
Hypersensitivity angiitis
based on the number of shared cases.
Similar with more cases:
- Other necrotizing vasculopathies
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1066 | 579 | 476 |
| Only index persons | 811 | 452 | 359 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 60.49 | 61.23 | 59.53 |
| Only index persons | 57.92 | 58.46 | 57.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 177 | 92 | 85 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 58.06 | 56.90 | 59.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 182
- Matched controls
- 1820
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
129.0
108
*
L04AX01
ATC
azathioprine; systemic
44.5
103.3
66
23
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
20.7
96.4
98
97
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
53.5
93.7
56
15
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
55.9
93.1
55
14
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
72.9
65
*
TK800
NOMESCO Finland
Hemodialysis
35.9
66.7
44
16
A11CC03
ATC
alfacalcidol; systemic
31.9
64.0
44
18
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
14.3
51.6
54
52
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
51.5
47
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
13.2
49.5
55
58
L04AA06
ATC
mycophenolic acid; systemic
80.1
47.4
52
9
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
44.6
41
*
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
39.0
36
*
H02AB04
ATC
methylprednisolone; systemic
7.5
38.4
77
163
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
12.4
38.0
42
43
Z94.0
ICD-10 Finland
Kidney transplant status
153.7
36.2
37
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
12.9
33.3
35
33
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
12.0
33.3
37
38
TPX10
NOMESCO Finland
Implantation of vascular injection port
14.2
32.5
32
27
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
85.9
32.2
35
5
Z49.1
ICD-10 Finland
Extracorporeal dialysis
57.6
32.0
37
8
WW400
NOMESCO Finland
Plasmaferesis
+∞
31.1
29
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
9.4
31.1
42
56
127
Kela drug reimbursment
Transplant complication
55.6
31.0
36
8
A12AA04
ATC
calcium carbonate; oral
55.6
31.0
36
8
4462A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Hypersensitivity angiitis
+∞
30.0
28
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
10.0
28.4
36
44
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.1
26.4
111
428
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.1
26.3
58
130
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
46.3
25.8
31
8
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
8.7
25.6
36
50
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
150.7
25.3
26
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
10.1
24.4
30
35
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
274.7
24.3
24
*
M05BA04
ATC
alendronic acid; oral
6.5
23.6
45
87
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.2
23.6
66
181
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
60.2
22.8
26
5
B03XA02
ATC
darbepoetin alfa; parenteral
22.5
22.2
32
17
Z2446
NOMESCO Finland
Social worker
7.8
22.2
34
52
WX892
NOMESCO Finland
Monitored bed care
7.0
21.5
37
64
GD1AD
NOMESCO Finland
Thorax CT examination
8.1
21.1
31
45
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
235.9
21.0
21
*
ZX120
NOMESCO Finland
Intravenous
5.6
20.6
47
107
TPH04
NOMESCO Finland
Cathetrisation of vein
4.3
19.6
72
240
N18.0
ICD-10 Finland
End-stage renal disease
62.1
19.4
22
*
L01AA01
ATC
cyclophosphamide; systemic
78.5
19.1
21
*
L04AD02
ATC
tacrolimus; systemic
78.5
19.1
21
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
43.5
19.1
23
6
H02AB07
ATC
prednisone; oral
5.1
18.8
48
120
ZXD05
NOMESCO Finland
Urgent procedure
3.9
18.4
90
365
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
18.2
122
609
KA1AE
NOMESCO Finland
Kidney ultrasound examination
19.6
18.0
27
16
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
18.0
17
*
N18.8
ICD-10 Finland
Other chronic renal failure
17.2
17.8
28
19
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
55.8
17.4
20
*
H02AB06
ATC
prednisolone; systemic
3.9
17.3
119
597
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.4
17.1
39
88
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
16.9
16
*
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
16.9
16
*
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
16.9
16
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.6
16.6
47
127
R50.9
ICD-10 Finland
Fever, unspecified
4.2
15.7
52
158
A07AA02
ATC
nystatin; oral
5.6
15.7
33
69
C03CA01
ATC
furosemide; systemic
3.5
15.6
95
434
V03AE01
ATC
polystyrene sulfonate; oral
35.1
15.1
19
6
L04AD01
ATC
ciclosporin; systemic
27.9
15.0
20
8
WW200
NOMESCO Finland
Immunization
16.1
15.0
24
17
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
14.8
14
*
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
14.8
14
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.4
14.6
80
339
TPH07
NOMESCO Finland
Cathetrisation of artery
4.7
14.3
38
97
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.3
13.3
40
112
B03XA01
ATC
erythropoietin; parenteral
31.0
13.2
17
6
L04AX03
ATC
methotrexate; systemic
4.8
13.2
33
80
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
6.1
13.0
24
44
ZX108
NOMESCO Finland
Inhalation
34.8
12.8
16
5
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
12.6
12
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
139.2
12.6
13
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.6
12.4
33
84
J01MA14
ATC
moxifloxacin; systemic
4.5
12.2
33
85
137
Kela drug reimbursment
Uraemia requiring dialysis
32.5
11.8
15
5
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
32.5
11.8
15
5
Z3226
NOMESCO Finland
Physiotherapist
3.4
11.8
55
207
C08CA02
ATC
felodipine; oral
4.2
11.7
35
97
J01MA02
ATC
ciprofloxacin; systemic
2.9
11.7
94
484
L01BA01
ATC
methotrexate; systemic
11.7
11.6
21
20
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.5
11.6
24
49
R4110
NOMESCO Finland
Physiotherapy
3.0
11.4
74
338
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.6
11.3
23
46
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
11.7
11.1
20
19
Z3231
NOMESCO Finland
Registered nurse
3.0
11.1
73
335
V03AE02
ATC
sevelamer; oral
63.8
10.8
12
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.1
10.6
56
226
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
116.4
10.5
11
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
10.5
10
*
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
10.5
10
*
TK810
NOMESCO Finland
Hemofiltration
34.8
10.5
13
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
8.8
10.5
22
28
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.4
10.3
28
72
Z49.0
ICD-10 Finland
Preparatory care for dialysis
31.9
9.5
12
*
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
+∞
9.5
9
*
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
9.5
9
*
N19
ICD-10 Finland
Unspecified kidney failure
7.8
9.3
21
30
B01AB04
ATC
dalteparin; parenteral
5.5
9.3
19
38
205
Kela drug reimbursment
Chronic hypertension
2.7
9.3
72
355
WX002
NOMESCO Finland
Sedation and analgesia
3.0
9.2
52
217
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
9.1
64
299
L04AA01
ATC
[U] ciclosporin
19.9
9.1
13
7
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.7
8.9
22
52
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
52.6
8.8
10
*
A02BC02
ATC
pantoprazole; systemic
2.9
8.7
138
951
TGC00
NOMESCO Finland
Bronchial lavation
8.6
8.6
18
23
ZXE20
NOMESCO Finland
More than three and less than five hours
3.0
8.6
44
173
A12AA12
ATC
[U] calcium acetate
94.2
8.5
9
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.4
8.5
34
115
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
8.4
8
*
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
8.4
8
*
P01BA02
ATC
hydroxychloroquine; oral
4.2
8.4
24
64
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.5
8.3
31
100
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.6
8.2
29
90
N17.8
ICD-10 Finland
Other acute renal failure
18.2
8.2
12
7
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
35.1
8.2
10
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
7.2
8.1
19
29
321
Kela drug reimbursment
Paricalcitol and cinacalcet
23.3
8.1
11
5
TKC20
NOMESCO Finland
Catheterisation of bladder
3.8
8.0
26
76
J01MA12
ATC
levofloxacin; systemic
2.8
7.9
49
213
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
7.8
48
207
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
47.0
7.8
9
*
ZXA00
NOMESCO Finland
Right side
2.5
7.8
66
335
B05DA
ATC
Isotonic solutions
26.3
7.7
10
*
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
83.3
7.5
8
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
7.4
41
167
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.7
7.4
25
75
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
7.9
7.4
16
22
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
7.3
7
*
N085, M318,
ICD-10 Finland
+∞
7.3
7
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.4
7.3
28
92
196
Kela drug reimbursment
Paricalcitol and cinacalcet
31.4
7.2
9
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.8
7.2
44
189
A41.9
ICD-10 Finland
Sepsis, unspecified
5.9
7.1
19
35
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.0
7.1
21
57
Z2221
NOMESCO Finland
Medical doctor
2.4
7.0
61
311
B01AB10
ATC
tinzaparin; parenteral
3.3
7.0
28
94
R31
ICD-10 Finland
Unspecified haematuria
3.1
6.9
31
112
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
7.7
6.9
15
21
H05BX01
ATC
cinacalcet; oral
17.5
6.8
10
6
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.7
6.8
23
69
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
41.6
6.8
8
*
3025
Kela drug reimbursment
Calcium carbonate
41.6
6.8
8
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
8.3
6.8
14
18
Z49.2
ICD-10 Finland
Other dialysis
23.5
6.7
9
*
R4190
NOMESCO Finland
Nutritional therapy
6.1
6.6
17
30
WX203
NOMESCO Finland
Infraclavicular plexus blockade
7.9
6.5
14
19
J01FF01
ATC
clindamycin; systemic
2.3
6.5
64
343
DHA10
NOMESCO Finland
Biopsy of cavity of nose
15.0
6.5
10
7
N25.0
ICD-10 Finland
Renal osteodystrophy
72.3
6.5
7
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
6.5
64
344
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
6.4
36
148
A02BC01
ATC
omeprazole; systemic
2.3
6.3
63
339
N085M, ,
ICD-10 Finland
+∞
6.3
6
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
6.3
6
*
KAS20
NOMESCO Finland
Allogenic transplantation of kidney from living donor
+∞
6.3
6
*
PAW37
NOMESCO Finland
Biopsy of temporal artery
+∞
6.3
6
*
4476A
ICD-9 Finland
Other disorders of arteries and arterioles, Arteritis, unspecified
+∞
6.3
6
*
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
6.3
6
*
D69.0
ICD-10 Finland
Allergic purpura
27.7
6.3
8
*
KBV00
NOMESCO Finland
Insertion of stent into ureter
27.7
6.3
8
*
N02AX02
ATC
tramadol; systemic, rectal
2.2
6.3
87
536
XQ845
NOMESCO Finland
Dermatoscopy
10.6
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
52
34
21.01
62.24
5.8
1.1
16.19
—
iu/ml
—
11
0
52
43
16.53
54.64
4.1
1.4
91.43
—
titre
—
7
0
40
23
22.01
50.39
2.7
1.1
400.00
—
titre
—
10
0
92
183
9.14
50.26
25.6
6.5
1.20
1.02
mmol/l
3.77
87
171
40
9
56.47
34.47
8.0
1.1
42.60
—
u/ml
—
5
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
36
49
8.91
26.03
3.4
2.0
0.24
0.31
u/ml
0.69
20
29
72
198
5.36
25.93
8.5
2.6
21.90
20.91
%
0.34
62
173
57
138
5.56
23.55
16.7
3.9
1.36
2.18
mmol/l
0.89
52
106
76
235
4.84
23.42
5.4
3.8
0.82
0.82
mmol/l
0.06
70
222
59
160
4.98
21.15
2.1
1.6
—
—
—
0
0
47
108
5.52
20.38
1.7
2.9
60.23
66.53
g/l
5.82
42
95
71
230
4.42
20.19
2.5
1.7
—
—
—
0
0
58
165
4.69
19.44
2.2
1.7
—
—
—
0
0
111
544
3.67
16.51
13.7
3.1
—
—
—
0
0
15
0
+∞
15.86
5.1
0.0
—
—
—
0
0
49
142
4.35
15.76
4.3
3.7
—
—
—
0
0
25
40
7.09
15.46
1.6
1.5
—
—
—
0
0
26
23
12.98
14.85
1.4
1.2
—
—
—
0
0
27
49
6.30
14.80
2.6
1.2
—
—
—
0
0
94
441
3.34
14.49
10.6
3.8
42.10
8.59
mg/mmol
1.29
79
270
25
23
12.41
14.03
1.6
1.2
344.06
263.07
u/ml
0.26
17
15
23
39
6.61
13.42
1.5
1.5
—
—
—
0
0
39
109
4.28
13.00
1.9
1.4
—
—
—
0
0
55
197
3.57
12.88
11.0
6.7
103.78
104.51
mmol/l
0.52
55
197
135
827
3.45
12.61
20.3
8.8
4.47
4.16
e9/l
0.86
128
722
32
80
4.64
12.26
7.6
5.7
24.32
24.99
mmol/l
0.48
32
80
123
727
3.13
11.95
34.7
7.4
1.21
1.21
mmol/l
0.11
110
614
120
701
3.09
11.88
9.4
3.7
0.00
0.00
estimate
-0.00
20
120
62
253
3.20
11.64
10.5
2.8
0.48
1.00
e6/l
1.79
46
151
118
691
3.01
11.48
9.4
3.7
0.00
0.00
estimate
-0.00
22
138
118
691
3.01
11.48
14.1
5.0
0.00
0.00
estimate
-0.00
21
122
58
241
3.06
10.42
11.1
2.9
1.70
2.12
e6/l
0.21
43
141
70
329
2.83
10.00
4.1
2.5
—
—
—
0
0
18
19
10.38
9.52
5.2
2.1
80.33
67.56
%
1.40
18
19
24
59
4.53
9.31
1.6
1.6
—
—
—
0
0
112
689
2.63
9.08
18.1
14.9
1.24
1.26
inr
0.08
22
204
19
27
7.72
8.51
1.5
1.5
—
—
—
0
0
16
17
10.20
8.47
1.1
1.1
—
—
—
0
0
11
5
23.26
8.11
1.0
1.0
—
—
—
0
0
19
31
6.72
7.79
1.4
1.6
—
—
—
0
0
18
28
7.01
7.63
1.6
1.6
—
—
—
0
0
18
28
7.01
7.63
1.6
1.6
—
—
—
0
0
20
50
4.37
7.57
1.7
2.8
—
—
—
0
0
17
26
7.10
7.31
1.4
1.6
—
—
—
0
0
13
13
10.66
7.16
1.3
1.2
—
—
—
0
0
19
35
5.93
7.15
5.2
1.1
—
—
—
0
0
14
17
8.82
6.97
1.7
1.4
—
—
—
0
0
16
25
6.91
6.81
1.6
1.4
—
—
—
0
0
17
29
6.35
6.80
1.4
1.1
2.00
2.46
u/ml
—
5
5
12
12
10.61
6.64
4.1
3.9
—
—
—
0
0
94
588
2.24
6.62
7.8
2.6
186.81
128.88
ug/l
2.12
89
533
101
652
2.23
6.57
4.3
2.8
—
—
—
0
0
12
13
9.79
6.39
1.8
1.4
—
—
—
0
0
14
20
7.48
6.35
1.5
1.6
—
—
—
0
0
14
20
7.48
6.35
1.5
1.6
—
—
—
0
0
54
274
2.38
6.18
1.8
1.7
1146.07
1192.56
nmol/l
0.13
48
212
15
25
6.44
6.14
1.2
1.6
—
—
—
0
0
23
75
3.37
6.01
2.7
1.4
—
—
—
0
0
16
30
5.74
6.00
1.7
1.4
—
—
—
0
0
16
30
5.74
6.00
1.7
1.4
—
—
—
0
0
17
36
5.10
5.78
1.7
1.3
—
—
—
0
0
121
867
2.18
5.74
10.7
5.0
6.60
6.72
mmol/l
0.32
115
802
16
42
4.08
5.67
1.4
1.2
—
—
—
0
0
52
269
2.31
5.65
4.1
3.8
642.49
131.16
ng/l
0.97
43
218
39
177
2.53
5.64
8.9
9.7
-0.67
1.40
mmol/l
1.74
30
146
15
30
5.35
5.39
1.2
1.6
—
—
—
0
0
64
367
2.15
5.37
2.6
2.0
2.75
3.20
mg/l
1.08
55
318
139
1068
2.28
5.32
10.5
3.7
19.48
12.52
mm/h
3.67
131
969
29
118
2.73
5.19
4.8
3.2
40.38
61.56
ml/min/173m2
—
8
50
8
6
13.86
5.13
1.5
1.2
—
—
—
0
0
16
46
3.72
5.02
1.7
1.6
—
—
—
0
0
10
14
7.48
4.72
1.2
1.7
—
—
—
0
0
22
82
2.91
4.61
15.0
3.8
24.50
25.10
mmol/l
0.33
22
82
10
15
6.98
4.53
1.2
1.7
—
—
—
0
0
9
12
7.82
4.41
1.3
1.4
—
—
—
0
0
15
39
4.10
4.31
1.6
1.4
—
—
—
0
0
76
499
1.90
4.18
5.7
3.4
2.31
2.36
mmol/l
2.46
68
435
8
11
7.55
3.90
2.9
2.5
—
—
—
0
0
10
20
5.22
3.74
5.0
2.5
3.93
4.56
e9/l
—
10
20
8
12
6.91
3.71
1.5
1.4
—
—
—
0
0
10
21
4.97
3.61
5.0
2.6
56.80
57.62
%
—
10
21
10
21
4.97
3.61
1.4
1.0
—
—
—
0
0
9
17
5.51
3.56
4.2
3.6
—
—
—
0
0
26
123
2.30
3.40
9.7
4.1
1.24
1.22
mmol/l
0.81
26
106
14
48
3.08
3.38
1.7
1.4
—
—
—
0
0
78
552
1.72
3.15
10.9
3.8
—
—
—
0
0
8
16
5.18
3.08
1.6
1.7
—
—
—
0
0
8
16
5.18
3.08
1.6
1.7
—
—
—
0
0
8
16
5.18
3.08
1.6
1.7
—
—
—
0
0
6
8
7.71
3.08
1.5
1.4
—
—
—
0
0
81
586
1.69
2.98
2.1
2.0
92.42
96.26
pmol/l
0.26
42
309
12
38
3.31
2.91
5.7
2.5
23.98
24.41
mmol/l
0.16
12
38
6
9
6.85
2.89
1.5
1.3
—
—
—
0
0
10
28
3.72
2.83
1.4
1.3
—
—
—
0
0
64
441
1.70
2.79
3.3
3.0
4711.93
1283.32
ng/l
0.76
54
370
5
6
8.52
2.76
2.6
2.0
115.40
76.00
ug/l
—
5
6
18
81
2.36
2.64
1.8
1.1
783.19
434.79
u/ml
0.21
18
74
6
11
5.60
2.56
1.2
1.0
—
—
—
0
0
7
17
4.24
2.38
2.3
1.8
—
—
—
0
0
17
79
2.27
2.33
14.1
4.3
54.22
52.83
%
0.08
17
79
12
47
2.66
2.32
1.2
1.2
—
—
—
0
0
11
40
2.86
2.32
7.3
3.9
1.17
1.59
mmol/l
1.77
11
40
12
48
2.61
2.23
1.2
1.2
—
—
—
0
0
7
19
3.79
2.17
1.1
1.2
—
—
—
0
0
6
14
4.39
2.17
2.2
4.5
—
—
—
0
0
5
10
5.11
2.08
1.4
1.1
—
—
—
0
0
5
10
5.11
2.08
1.4
1.1
—
—
—
0
0
12
51
2.45
1.99
3.8
1.8
—
—
—
0
0
5
11
4.64
1.95
1.4
1.1
—
—
—
0
0
5
11
4.64
1.95
1.4
1.1
—
—
—
0
0
5
11
4.64
1.95
1.4
1.1
—
—
—
0
0
53
379
1.56
1.91
10.2
3.8
0.00
0.00
estimate
-0.00
19
120
7
22
3.27
1.90
2.0
1.1
—
—
—
0
0
19
101
1.98
1.89
2.1
1.5
—
—
—
0
0
11
49
2.32
1.67
3.7
1.7
—
—
—
0
0
5
14
3.64
1.62
1.6
1.2
—
—
—
0
0
7
29
2.47
1.40
1.1
1.1
—
—
—
0
0
6
23
2.66
1.38
1.5
1.5
—
—
—
0
0
6
23
2.66
1.38
1.0
1.0
—
—
—
0
0
15
83
1.88
1.36
1.2
1.3
—
—
—
0
0
70
586
1.32
0.99
5.2
3.8
126.21
42.01
ng/l
0.72
57
415
153
1437
1.41
0.90
49.9
14.4
25.49
24.79
mg/l
0.10
146
1138
0
25
0.00
0.79
0.0
1.5
—
—
—
0
0
6
34
1.79
0.77
1.2
1.4
—
—
—
0
0
100
906
1.23
0.68
3.9
2.9
70.94
50.66
u/l
0.69
94
849
29
226
1.34
0.67
1.2
1.2
26.87
37.81
iu/ml
0.49
11
75
130
1377
0.80
0.62
4.8
4.6
5.90
5.98
mmol/l
0.21
121
1251
0
21
0.00
0.60
0.0
1.6
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
0
23
0.00
0.58
0.0
2.2
—
34.91
—
0
8
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
6
39
1.56
0.53
1.0
1.3
—
—
—
0
0
33
395
0.80
0.52
3.9
4.3
27.45
22.00
%
0.79
17
195
22
177
1.28
0.43
2.3
4.6
3.90
69.31
ug/l
0.87
17
151
5
32
1.58
0.42
1.8
1.4
—
—
—
0
0
19
150
1.30
0.42
1.8
2.4
0.24
0.22
g/l
0.64
19
137
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
5
34
1.48
0.40
1.4
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
125
1306
0.86
0.37
5.6
4.6
1.98
1.94
mu/l
0.15
118
1162
135
1308
1.12
0.25
7.7
6.0
37.33
40.16
mmol/mol
4.67
130
1209
12
145
0.82
0.22
1.4
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
25.39
—
0
10
21
183
1.17
0.21
1.6
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
139
1424
0.90
0.20
6.4
5.1
2.69
2.69
mmol/l
0.02
134
1302
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
90
861
1.09
0.20
3.3
2.8
—
—
—
0
0
130
1335
0.91
0.20
5.6
4.1
1.38
1.27
mmol/l
1.03
123
1210
109
1053
1.09
0.19
5.0
3.9
14.85
14.84
pmol/l
0.01
101
934
6
75
0.79
0.16
1.3
1.0
—
—
—
0
0
156
1582
0.90
0.14
68.5
21.4
37.76
40.02
%
4.81
147
1495
28
258
1.10
0.13
1.5
1.5
—
—
—
0
0
136
1383
0.93
0.11
6.2
4.5
1.50
1.46
mmol/l
0.55
131
1264
137
1390
0.94
0.09
6.2
4.5
4.62
4.58
mmol/l
0.18
131
1277
133
1350
0.94
0.09
41.6
13.7
60.41
79.47
ml/min/173m2
7.41
119
1091
12
133
0.90
0.08
1.3
2.1
—
—
—
0
0
34
326
1.05
0.06
1.4
1.2
0.84
0.91
u/ml
—
7
78
18
190
0.94
0.04
18.5
8.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.0
—
14.09
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
7.32
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_HYPERANG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HYPERANG | 3.134 [2.31, 4.24] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.178 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 383 females with M13_HYPERANG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HYPERANG | 2.479 [1.81, 3.4] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 118 out of 304 males with M13_HYPERANG died.
Mortality risk
Mortality risk for people of age
years, who have M13_HYPERANG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.298% | 0.555% |
| 5 | 1.629% | 3.059% |
| 10 | 4.34% | 7.777% |
| 15 | 7.969% | 14.342% |
| 20 | 13.634% | 23.512% |
Relationships between endpoints
↥Index endpoint: M13_HYPERANG – Hypersensitivity angiitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data