Complications of anaesthesia during the puerperium

O15_PUERP_ANEST_COMPL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O89
  • Cause of death: ICD-10 O89

2 out of 7 registries used, show all original rules.

130

4. Check minimum number of events

None

130

5. Include endpoints

None

130

6. Filter based on genotype QC (FinnGen only)

130

Control definitions (FinnGen only)

Control exclude
O15_COMPLIC_PUERP

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
O85-O92
Name in latin
Complicationes anaesthesiae in puerperio

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 926 926 -
Only index persons 924 924 -
Unadjusted period prevalence (%)
Whole population 0.03 0.03 -
Only index persons 0.03 0.03 -
Median age at first event (years)
Whole population - 29.67 -
Only index persons - 29.66 -

-FinnGen-

Key figures

All Female Male
Number of individuals 130 130 -
Unadjusted period prevalence (%) 0.04 0.04 -
Median age at first event (years) 30.50 30.50 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
121
Matched controls
1209
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O89.4
ICD-10 Finland
Spinal and epidural anaesthesia-induced headache during the puerperium
+∞
150.4
111
*
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
195.6
81.2
78
11
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
5.2
15.1
59
186
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
12.0
7.5
13
12
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
3.8
7.0
31
101

Mortality – FinRegistry

Association

Association between endpoint O15_PUERP_ANEST_COMPL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_PUERP_ANEST_COMPL.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_PUERP_ANEST_COMPL – Complications of anaesthesia during the puerperium

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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