hypospadias: Hypospadias is the displacement of the urethral meatus on the ventrum of the penis. This abnormality is associated with a varyingly bent, twisted penis and opened dorsal prepuce.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleonly males |
226754 |
2. Check conditionsNone |
226754 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
143 |
4. Check minimum number of eventsNone |
143 |
5. Include endpointsNone |
143 |
6. Filter based on genotype QC (FinnGen only) |
132 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_GENITAL_ORGANS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF12
- Parent code in ICD-10
- Q5
- Name in latin
- Hypospadia
Similar endpoints
↥List of similar endpoints to
Hypospadias
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of genital organs
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 132 | - | 132 |
| Unadjusted period prevalence (%) | 0.06 | - | 0.06 |
| Median age at first event (years) | 10.40 | - | 10.40 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 143
- Matched controls
- 1430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q54.0
ICD-10 Finland
Hypospadias, balanic
+∞
90.5
77
*
XKD00
NOMESCO Finland
Uroflowmetry
11.8
48.2
68
102
Q54.9
ICD-10 Finland
Hypospadias, unspecified
+∞
45.2
41
*
Q54.1
ICD-10 Finland
Hypospadias, penile
+∞
40.6
37
*
KGH61
NOMESCO Finland
Correction of distal hypospadia
+∞
40.6
37
*
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
9.8
36.6
54
83
UKC02
NOMESCO Finland
Cystoscopy
8.3
28.4
46
77
Q54.2
ICD-10 Finland
Hypospadias, penoscrotal
+∞
21.4
20
*
Q54.4
ICD-10 Finland
Congenital chordee
+∞
18.1
17
*
J01EA01
ATC
trimethoprim; systemic
7.7
17.8
28
44
TKD00
NOMESCO Finland
Dilatation of urethra
89.5
14.9
16
*
7526B
ICD-9 Finland
Congenital anomalies of genital organs, Hypospadias and epispadias[HYPOSPADIA]
+∞
14.8
14
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.9
14.5
67
262
N35.9
ICD-10 Finland
Urethral stricture, unspecified
59.6
14.1
16
*
KGH62
NOMESCO Finland
Total correction of proximal hypospadia
+∞
11.6
11
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
6.0
10.4
20
38
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
6.0
10.4
20
38
KDH10
NOMESCO Finland
Meatoplasty of urethra
+∞
9.5
9
*
KDH70
NOMESCO Finland
Plastic repair of stricture of urethra
+∞
9.5
9
*
N30.0
ICD-10 Finland
Acute cystitis
10.0
8.8
17
19
ZXD10
NOMESCO Finland
Scheduled procedure
2.9
8.7
64
314
WX308
NOMESCO Finland
Sacral anesthesy
21.6
8.6
12
6
N35.8
ICD-10 Finland
Other urethral stricture
95.4
8.5
9
*
KFH00
NOMESCO Finland
Operation for undescended or ectopic testis
+∞
8.4
8
*
7421
FHL
Single-stage total correction, in distal hypospadia
+∞
8.4
8
*
Q53.2
ICD-10 Finland
Undescended testicle, bilateral
+∞
7.3
7
*
KGH69
NOMESCO Finland
Other correction of hypospadia
+∞
7.3
7
*
N99.1
ICD-10 Finland
Postprocedural urethral stricture
+∞
7.3
7
*
KGH20
NOMESCO Finland
Correction of induration or curvature of penis
+∞
7.3
7
*
KDV12
NOMESCO Finland
Urethroscopic internal urethrotomy
31.8
7.2
9
*
J01MA02
ATC
ciprofloxacin; systemic
2.8
7.2
46
206
121
Kela drug reimbursment
Severe hypofunction of sexual glands
73.0
6.5
7
*
Q53.1
ICD-10 Finland
Undescended testicle, unilateral
+∞
6.3
6
*
75220
ICD-8 Finland
Congenital anomalies of genital organs, Hypospadia glandis
+∞
6.3
6
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.2
6.0
17
45
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
71
2.24
2.00
2.7
3.1
—
—
—
0
0
33
210
1.74
1.94
5.4
3.2
0.00
0.01
estimate
0.49
18
79
43
298
1.63
1.84
5.0
2.9
—
—
—
0
0
36
239
1.68
1.81
2.0
1.7
92.59
92.14
pmol/l
0.02
24
128
48
344
1.60
1.79
5.1
3.5
—
—
—
0
0
55
408
1.57
1.77
4.7
3.1
0.00
0.01
estimate
0.49
18
85
55
413
1.54
1.66
4.7
3.1
0.00
0.00
estimate
-0.00
17
78
54
407
1.53
1.59
6.1
4.3
0.00
0.00
estimate
-0.00
17
87
5
15
3.41
1.53
5.4
6.1
1.80
3.44
ug/l
—
5
15
5
15
3.41
1.53
3.6
4.5
54.00
50.33
%
—
5
15
5
16
3.20
1.45
1.4
1.1
281.40
214.87
pmol/l
—
5
16
5
19
2.69
1.22
4.0
2.3
201.80
179.97
ug/min
—
5
13
81
696
1.38
1.08
3.4
2.8
14.70
14.96
pmol/l
0.46
70
632
94
836
1.36
0.96
3.7
3.4
2.08
2.07
mu/l
0.03
89
772
24
170
1.49
0.93
1.7
2.1
1.40
1.50
%
0.24
19
157
56
464
1.34
0.90
8.5
10.6
1.24
1.22
mmol/l
1.12
48
420
15
97
1.61
0.85
1.7
1.5
—
—
—
0
0
8
46
1.78
0.84
12.9
16.2
24.75
23.81
mmol/l
—
8
46
8
48
1.71
0.80
2.4
13.5
1.18
1.64
%
—
8
48
0
24
0.00
0.80
0.0
1.3
—
27.00
—
0
5
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
17
117
1.51
0.76
2.2
2.1
365.00
336.37
nmol/l
0.30
17
110
11
68
1.67
0.74
1.4
1.8
—
—
—
0
0
7
42
1.70
0.69
1.7
2.3
—
—
—
0
0
5
95
0.51
0.69
1.2
1.0
—
—
—
0
0
5
30
1.69
0.62
1.2
2.1
—
—
—
0
0
0
20
0.00
0.61
0.0
1.5
—
20.20
—
0
15
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
2.6
—
—
—
0
0
28
225
1.30
0.55
2.0
1.9
1.41
1.38
mmol/l
0.07
22
200
43
366
1.25
0.54
3.4
3.2
—
—
—
0
0
9
62
1.48
0.54
12.3
13.0
0.61
0.71
%
—
9
62
9
62
1.48
0.54
12.2
13.1
1.00
1.63
%
—
9
62
22
172
1.33
0.52
6.6
8.4
0.85
0.82
mmol/l
0.61
22
167
103
965
1.24
0.51
3.8
3.5
—
—
—
0
0
23
182
1.31
0.50
4.8
2.9
0.62
0.67
e6/l
0.05
15
108
74
674
1.20
0.48
6.8
13.1
3.86
3.86
e9/l
0.00
63
566
75
815
0.83
0.47
3.9
3.4
5.96
5.80
mmol/l
0.36
61
757
22
176
1.30
0.45
4.9
3.4
1.75
0.69
e6/l
0.39
14
103
17
132
1.33
0.42
6.8
9.2
105.47
104.68
mmol/l
0.33
17
132
5
32
1.58
0.42
6.4
10.5
—
4318.33
—
0
6
5
33
1.53
0.42
1.8
6.2
70.78
59.51
%
—
5
33
0
15
0.00
0.41
0.0
1.1
—
89.80
—
0
15
0
16
0.00
0.41
0.0
2.9
—
0.00
—
0
16
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
7.1
—
—
—
0
0
0
16
0.00
0.41
0.0
7.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
2.00
—
0
10
9
67
1.37
0.39
4.3
2.1
5.84
5.36
ug/l
—
9
61
5
36
1.40
0.38
8.2
6.3
23.60
23.51
mmol/l
—
5
36
9
71
1.29
0.37
1.1
1.2
—
—
—
0
0
6
41
1.48
0.36
1.7
2.4
—
—
—
0
0
14
110
1.30
0.33
1.9
2.0
—
—
—
0
0
22
184
1.23
0.33
9.1
13.5
25.22
24.52
mmol/l
0.40
22
184
17
138
1.26
0.32
2.4
2.1
—
—
—
0
0
85
896
0.87
0.30
4.7
3.8
2.74
2.75
mmol/l
0.06
75
846
8
65
1.24
0.27
1.3
1.9
—
—
—
0
0
39
354
1.14
0.24
4.7
4.3
2.08
2.70
ug/l
0.27
34
322
31
345
0.87
0.24
1.6
1.5
10.71
2.64
u/ml
—
7
71
5
37
1.36
0.24
1.0
1.1
—
—
—
0
0
5
38
1.33
0.23
1.0
1.1
—
—
—
0
0
82
858
0.90
0.22
3.9
3.2
1.39
1.31
mmol/l
0.51
74
814
0
11
0.00
0.21
0.0
1.0
—
10.63
—
0
11
0
11
0.00
0.21
0.0
4.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
5.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
2.9
—
1237.67
—
0
12
0
13
0.00
0.21
0.0
3.2
—
0.00
—
0
13
0
13
0.00
0.21
0.0
3.2
—
0.00
—
0
13
0
13
0.00
0.21
0.0
2.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
31
280
1.14
0.20
3.9
4.1
18.95
21.53
%
0.35
13
123
20
179
1.14
0.15
1.7
4.1
0.66
2.07
mg/l
1.77
14
142
32
345
0.91
0.15
2.3
1.8
—
—
—
0
0
23
209
1.12
0.14
2.5
2.7
0.76
0.77
ug/l
0.00
14
127
86
886
0.93
0.13
4.2
3.5
1.29
1.29
mmol/l
0.06
76
841
12
104
1.17
0.13
1.8
1.9
—
—
—
0
0
29
269
1.10
0.12
4.2
3.4
21.10
24.99
ng/l
0.30
16
168
37
352
1.07
0.09
5.9
10.3
1.00
1.26
inr
5.29
12
101
5
61
0.81
0.08
2.6
2.4
—
—
—
0
0
8
75
1.07
0.07
12.5
8.7
—
—
—
0
0
80
786
1.04
0.05
4.7
4.4
37.43
38.91
mmol/mol
0.61
75
748
111
1098
1.05
0.04
15.1
12.3
25.21
24.61
mg/l
0.06
81
780
23
221
1.05
0.03
3.7
3.3
—
—
—
0
0
110
1109
0.96
0.02
16.7
13.0
77.61
75.21
umol/l
0.37
110
1109
126
1267
0.95
0.01
18.9
17.9
4.85
4.78
e12/l
0.82
120
1215
126
1267
0.95
0.01
19.5
18.6
42.70
45.44
%
0.34
119
1210
15
146
1.03
0.00
4.7
10.9
22.93
23.43
mmol/l
0.27
15
146
89
892
0.99
0.00
4.2
3.5
4.45
4.44
mmol/l
0.03
80
850
20
203
0.98
0.00
2.9
2.3
—
—
—
0
0
81
805
1.01
0.00
14.6
10.4
94.16
95.18
ml/min/173m2
0.11
60
631
126
1265
0.97
0.00
18.9
18.0
250.30
250.32
e9/l
0.00
120
1215
18
185
0.97
0.00
2.9
2.2
—
—
—
0
0
5
49
1.02
-0.00
2.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
54.67
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
25.82
—
0
9
0
7
0.00
-0.00
0.0
1.3
—
17.29
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
37.40
—
0
5
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.0
—
92.40
—
0
5
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
134.67
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
2.74
—
0
5
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
10.60
—
0
5
5
54
0.92
-0.00
2.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
614.60
—
0
5
0
7
0.00
-0.00
0.0
3.6
—
212.27
—
0
7
6
67
0.89
-0.00
2.2
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
98.88
—
0
8
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: Q17_HYPOSPADIAS – Hypospadias
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).