hypospadias: Hypospadias is the displacement of the urethral meatus on the ventrum of the penis. This abnormality is associated with a varyingly bent, twisted penis and opened dorsal prepuce.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly males |
226837 |
2. Check conditionsNone |
226837 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
143 |
4. Check minimum number of eventsNone |
143 |
5. Include endpointsNone |
143 |
6. Filter based on genotype QC (FinnGen only) |
143 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_GENITAL_ORGANS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF12
- Parent code in ICD-10
- Q5
- Name in latin
- Hypospadia
Similar endpoints
↥List of similar endpoints to
Hypospadias
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of genital organs
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 143 | - | 143 |
| Unadjusted period prevalence (%) | 0.06 | - | 0.06 |
| Median age at first event (years) | 10.12 | - | 10.12 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 135
- Matched controls
- 1348
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q54.0
ICD-10 Finland
Hypospadias, balanic
+∞
83.1
71
*
Q54.9
ICD-10 Finland
Hypospadias, unspecified
+∞
44.2
40
*
KGH61
NOMESCO Finland
Correction of distal hypospadia
+∞
39.5
36
*
Q54.1
ICD-10 Finland
Hypospadias, penile
+∞
34.9
32
*
XKD00
NOMESCO Finland
Uroflowmetry
10.3
28.6
65
111
Q54.2
ICD-10 Finland
Hypospadias, penoscrotal
+∞
20.3
19
*
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
8.0
19.4
49
90
Q54.4
ICD-10 Finland
Congenital chordee
+∞
19.2
18
*
UKC02
NOMESCO Finland
Cystoscopy
6.3
14.5
42
90
7526B
ICD-9 Finland
Congenital anomalies of genital organs, Hypospadias and epispadias[HYPOSPADIA]
+∞
13.8
13
*
TKD00
NOMESCO Finland
Dilatation of urethra
71.3
11.8
13
*
N35.9
ICD-10 Finland
Urethral stricture, unspecified
27.9
11.4
15
6
KGH62
NOMESCO Finland
Total correction of proximal hypospadia
+∞
10.5
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.3
9.7
66
301
WX308
NOMESCO Finland
Sacral anesthesy
26.1
9.1
12
5
J01EA01
ATC
trimethoprim; systemic
5.2
8.6
27
62
KFH00
NOMESCO Finland
Operation for undescended or ectopic testis
+∞
8.4
8
*
KDH70
NOMESCO Finland
Plastic repair of stricture of urethra
84.5
7.5
8
*
KDH10
NOMESCO Finland
Meatoplasty of urethra
+∞
7.4
7
*
7421
FHL
Single-stage total correction, in distal hypospadia
+∞
7.4
7
*
KGH20
NOMESCO Finland
Correction of induration or curvature of penis
+∞
7.4
7
*
J01MA02
ATC
ciprofloxacin; systemic
2.9
6.7
46
202
UKD02
NOMESCO Finland
Urethroscopy
73.2
6.5
7
*
KDV12
NOMESCO Finland
Urethroscopic internal urethrotomy
19.1
6.4
9
5
Q53.2
ICD-10 Finland
Undescended testicle, bilateral
+∞
6.3
6
*
Q53.1
ICD-10 Finland
Undescended testicle, unilateral
+∞
6.3
6
*
KGH69
NOMESCO Finland
Other correction of hypospadia
+∞
6.3
6
*
75220
ICD-8 Finland
Congenital anomalies of genital organs, Hypospadia glandis
+∞
6.3
6
*
JAH01
NOMESCO Finland
Laparoscopy
13.4
6.2
10
8
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: Q17_HYPOSPADIAS – Hypospadias
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).