hypospadias: Hypospadias is the displacement of the urethral meatus on the ventrum of the penis. This abnormality is associated with a varyingly bent, twisted penis and opened dorsal prepuce.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly males |
226837 |
2. Check conditionsNone |
226837 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
143 |
4. Check minimum number of eventsNone |
143 |
5. Include endpointsNone |
143 |
6. Filter based on genotype QC (FinnGen only) |
143 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_GENITAL_ORGANS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF12
- Parent code in ICD-10
- Q5
- Name in latin
- Hypospadia
Similar endpoints
↥List of similar endpoints to
Hypospadias
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of genital organs
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 143 | - | 143 |
| Unadjusted period prevalence (%) | 0.06 | - | 0.06 |
| Median age at first event (years) | 10.12 | - | 10.12 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 135
- Matched controls
- 1348
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q54.0
ICD-10 Finland
Hypospadias, balanic
+∞
83.1
71
*
Q54.9
ICD-10 Finland
Hypospadias, unspecified
+∞
44.2
40
*
KGH61
NOMESCO Finland
Correction of distal hypospadia
+∞
39.5
36
*
Q54.1
ICD-10 Finland
Hypospadias, penile
+∞
34.9
32
*
XKD00
NOMESCO Finland
Uroflowmetry
10.3
28.6
65
111
Q54.2
ICD-10 Finland
Hypospadias, penoscrotal
+∞
20.3
19
*
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
8.0
19.4
49
90
Q54.4
ICD-10 Finland
Congenital chordee
+∞
19.2
18
*
UKC02
NOMESCO Finland
Cystoscopy
6.3
14.5
42
90
7526B
ICD-9 Finland
Congenital anomalies of genital organs, Hypospadias and epispadias[HYPOSPADIA]
+∞
13.8
13
*
TKD00
NOMESCO Finland
Dilatation of urethra
71.3
11.8
13
*
N35.9
ICD-10 Finland
Urethral stricture, unspecified
27.9
11.4
15
6
KGH62
NOMESCO Finland
Total correction of proximal hypospadia
+∞
10.5
10
*
WX308
NOMESCO Finland
Sacral anesthesy
26.1
9.1
12
5
J01EA01
ATC
trimethoprim; systemic
5.2
8.6
27
62
KFH00
NOMESCO Finland
Operation for undescended or ectopic testis
+∞
8.4
8
*
KDH70
NOMESCO Finland
Plastic repair of stricture of urethra
84.5
7.5
8
*
KGH20
NOMESCO Finland
Correction of induration or curvature of penis
+∞
7.4
7
*
KDH10
NOMESCO Finland
Meatoplasty of urethra
+∞
7.4
7
*
7421
FHL
Single-stage total correction, in distal hypospadia
+∞
7.4
7
*
J01MA02
ATC
ciprofloxacin; systemic
2.9
6.7
46
202
UKD02
NOMESCO Finland
Urethroscopy
73.2
6.5
7
*
KDV12
NOMESCO Finland
Urethroscopic internal urethrotomy
19.1
6.4
9
5
75220
ICD-8 Finland
Congenital anomalies of genital organs, Hypospadia glandis
+∞
6.3
6
*
Q53.1
ICD-10 Finland
Undescended testicle, unilateral
+∞
6.3
6
*
Q53.2
ICD-10 Finland
Undescended testicle, bilateral
+∞
6.3
6
*
KGH69
NOMESCO Finland
Other correction of hypospadia
+∞
6.3
6
*
JAH01
NOMESCO Finland
Laparoscopy
13.4
6.2
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
71
2.24
2.00
2.7
3.1
—
—
—
0
0
33
210
1.74
1.94
5.4
3.2
0.0
0.0
estimate
0.49
18
79
43
298
1.63
1.84
5.0
2.9
—
—
—
0
0
55
406
1.58
1.82
4.7
3.1
0.0
0.0
estimate
0.00
17
82
36
239
1.68
1.81
2.0
1.7
92.6
92.1
pmol/l
0.02
24
128
48
344
1.60
1.79
5.2
3.5
—
—
—
0
0
55
413
1.54
1.66
4.7
3.1
0.0
0.0
estimate
0.00
17
78
54
407
1.53
1.59
6.1
4.3
0.0
0.0
estimate
0.00
17
87
5
19
2.69
1.22
4.2
2.3
201.8
180.0
ug/min
—
5
13
81
696
1.38
1.08
3.4
2.8
14.7
15.0
pmol/l
0.46
70
632
94
835
1.37
0.97
3.7
3.4
2.1
2.1
mu/l
0.03
89
771
24
170
1.49
0.93
1.7
2.1
1.4
1.5
%
0.24
19
157
56
464
1.34
0.90
8.5
10.6
1.2
1.2
mmol/l
1.30
47
418
15
97
1.61
0.85
1.7
1.5
—
—
—
0
0
8
48
1.71
0.80
2.4
13.5
1.2
1.6
%
—
8
48
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
17
117
1.51
0.76
2.2
2.1
365.0
336.4
nmol/l
0.30
17
110
11
68
1.67
0.74
1.4
1.8
—
—
—
0
0
7
42
1.70
0.69
1.7
2.3
—
—
—
0
0
5
95
0.51
0.69
1.2
1.0
—
—
—
0
0
5
30
1.69
0.62
1.2
2.1
—
—
—
0
0
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
0
20
0.00
0.61
0.0
1.5
—
20.2
—
0
15
0
21
0.00
0.60
0.0
2.6
—
—
—
0
0
0
21
0.00
0.60
0.0
2.6
—
3.5
—
0
16
28
225
1.30
0.55
2.0
1.9
1.4
1.4
mmol/l
0.07
22
200
43
366
1.25
0.54
5.3
4.4
—
—
—
0
0
9
62
1.48
0.54
12.2
13.1
1.0
1.6
%
—
9
62
9
62
1.48
0.54
12.3
13.0
0.6
0.7
%
—
9
62
22
172
1.33
0.52
6.6
8.4
0.9
0.8
mmol/l
0.61
22
167
103
965
1.24
0.51
3.8
3.5
—
—
—
0
0
23
182
1.31
0.50
4.8
2.9
0.6
0.7
e6/l
0.05
15
108
74
674
1.20
0.48
6.8
13.1
3.9
3.9
e9/l
0.00
63
566
75
815
0.83
0.47
3.9
3.4
6.0
5.8
mmol/l
0.36
61
757
22
176
1.30
0.45
4.9
3.4
1.8
0.7
e6/l
0.39
14
103
5
32
1.58
0.42
6.4
10.5
—
4318.3
—
0
6
5
33
1.53
0.42
1.8
6.2
70.8
59.5
%
—
5
33
0
15
0.00
0.41
0.0
1.1
—
89.8
—
0
15
0
16
0.00
0.41
0.0
2.9
—
0.0
—
0
16
0
16
0.00
0.41
0.0
7.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
7.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
2.0
—
0
10
9
67
1.37
0.39
4.3
2.1
5.8
5.4
ug/l
—
9
61
21
171
1.27
0.38
4.3
11.0
0.9
1.2
mmol/l
0.20
16
135
9
71
1.29
0.37
1.1
1.2
—
—
—
0
0
6
41
1.48
0.36
1.7
2.4
—
—
—
0
0
15
188
0.77
0.36
7.9
7.5
5.0
5.1
kpa
0.07
15
182
14
110
1.30
0.33
1.9
2.0
—
—
—
0
0
22
184
1.23
0.33
9.1
13.5
25.2
24.5
mmol/l
0.40
22
184
17
138
1.26
0.32
2.4
2.1
—
—
—
0
0
85
896
0.87
0.30
4.7
3.8
2.7
2.8
mmol/l
0.06
75
846
8
65
1.24
0.27
1.3
1.9
—
—
—
0
0
39
354
1.14
0.24
4.7
4.3
2.1
2.7
ug/l
0.27
34
322
31
345
0.87
0.24
1.6
1.5
10.7
2.6
u/ml
—
7
71
5
37
1.36
0.24
1.0
1.1
—
—
—
0
0
5
38
1.33
0.23
1.0
1.1
—
—
—
0
0
82
858
0.90
0.22
3.9
3.2
1.4
1.3
mmol/l
0.51
74
814
112
1087
1.14
0.22
14.1
15.3
42.4
41.4
%
1.04
90
940
0
11
0.00
0.21
0.0
1.0
—
10.6
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
4.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
5.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.9
—
1237.7
—
0
12
0
13
0.00
0.21
0.0
3.2
—
0.0
—
0
13
0
13
0.00
0.21
0.0
3.2
—
0.0
—
0
13
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
31
280
1.14
0.20
3.9
4.1
18.9
21.5
%
0.35
13
123
20
179
1.14
0.15
1.7
4.1
0.7
2.1
mg/l
1.77
14
142
32
345
0.91
0.15
2.3
1.8
—
—
—
0
0
23
209
1.12
0.14
2.5
2.7
0.8
0.8
ug/l
0.00
14
127
86
886
0.93
0.13
4.2
3.5
1.3
1.3
mmol/l
0.05
76
841
12
104
1.17
0.13
1.8
1.9
—
—
—
0
0
29
269
1.10
0.12
4.2
3.4
23.2
25.0
ng/l
0.12
14
167
5
61
0.81
0.08
2.6
2.4
—
—
—
0
0
8
75
1.07
0.07
12.5
8.7
—
—
—
0
0
80
786
1.04
0.05
4.7
4.4
37.4
38.9
mmol/mol
0.61
75
748
111
1098
1.05
0.04
15.1
12.3
25.2
24.6
mg/l
0.06
81
780
23
221
1.05
0.03
3.7
3.3
—
—
—
0
0
110
1109
0.96
0.02
16.7
13.0
77.6
75.2
umol/l
0.37
110
1109
81
804
1.02
0.00
14.7
10.4
94.2
95.1
ml/min/173m2
0.11
60
628
15
146
1.03
0.00
4.7
10.9
23.3
23.6
mmol/l
0.20
15
140
89
892
0.99
0.00
4.2
3.5
4.4
4.4
mmol/l
0.03
80
850
20
203
0.98
0.00
2.9
2.3
—
—
—
0
0
18
185
0.97
0.00
2.9
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
3.6
—
212.3
—
0
7
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
2.7
—
0
5
0
5
0.00
0.00
0.0
1.0
—
37.4
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
6
67
0.89
0.00
2.2
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.6
—
—
—
0
0
5
49
1.02
0.00
2.0
1.9
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.0
—
92.4
—
0
5
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
614.6
—
0
5
0
7
0.00
0.00
0.0
1.3
—
17.3
—
0
7
5
54
0.92
0.00
2.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
25.8
—
0
9
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
134.7
—
0
6
0
9
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
54.7
—
0
6
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
10.6
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
2.6
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: Q17_HYPOSPADIAS – Hypospadias
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).