Other and unspecified syphilis

AB1_SYPHILIS_NOS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A53 Hospital discharge: ICD-9 — 097 Hospital discharge: ICD-8 — 097 Cause of death: ICD-10 — A53 Cause of death: ICD-9 — 097 Cause of death: ICD-8 — 097 2 out of 7 registries used, show all original rules.	104
4. Check minimum number of events None	104
5. Include endpoints None	104
6. Filter based on genotype QC (FinnGen only)	104

Control definitions (FinnGen only)

Control exclude: AB1_SEXUAL_TRANSMISSION

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF5

NAME	AB1_SYPHILIS_NOS
CONTROL_EXCLUDE	AB1_SEXUAL_TRANSMISSION
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A53
HD_ICD_9	097
HD_ICD_8	097
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A53
COD_ICD_9	097
COD_ICD_8	097
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other and unspecified syphilis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	893	369	469
Only index persons	694	310	384
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	42.22	37.40	47.04
Only index persons	40.34	35.56	44.20

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	104	29	75
Unadjusted period prevalence (%)	0.03	0.01	0.03
Median age at first event (years)	44.22	39.31	46.12

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
87: Matched controls
868

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A53.9

ICD-10 Finland

Syphilis, unspecified

+∞

63.5

B23.1

ICD-10 Finland

HIV disease resulting in (persistent) generalized lymphadenopathy

213.8

29.7

WW200

NOMESCO Finland

Immunization

38.0

27.7

Z11.3

ICD-10 Finland

Special screening examination for infections with a predominantly sexual mode of transmission

26.0

26.6

A53.0

ICD-10 Finland

Latent syphilis, unspecified as early or late

+∞

24.1

B24

ICD-10 Finland

Unspecified human immunodeficiency virus [HIV] disease

+∞

19.5

A51.0

ICD-10 Finland

Primary genital syphilis

+∞

13.9

Z21

ICD-10 Finland

Asymptomatic human immunodeficiency virus [HIV] infection status

+∞

12.8

A56.3

ICD-10 Finland

Chlamydial infection of anus and rectum

+∞

11.7

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

9.0

11.5

A51.9

ICD-10 Finland

Early syphilis, unspecified

+∞

10.6

Z25.1

ICD-10 Finland

Need for immunization against influenza

10.3

8.8

TAB00

NOMESCO Finland

Lumbar puncture

10.6

8.5

A56.0

ICD-10 Finland

Chlamydial infection of lower genitourinary tract

+∞

8.5

09710

ICD-8 Finland

Other syphilis and not specified, Latent syphilis, unspecified

+∞

8.5

B23.8

ICD-10 Finland

HIV disease resulting in other specified conditions

+∞

8.5

ZX114

NOMESCO Finland

Intramuscular

37.2

8.3

A54.6

ICD-10 Finland

Gonococcal infection of anus and rectum

+∞

7.4

A52.1

ICD-10 Finland

Symptomatic neurosyphilis

+∞

7.4

F43.29

ICD-10 Finland

Adaptation disorder UNS

24.8

6.8

A54.5

ICD-10 Finland

Gonococcal pharyngitis

+∞

6.3

A51.3

ICD-10 Finland

Secondary syphilis of skin and mucous membranes

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3029634) Reagin Ab [Titer] in Serum by VDRL

78.37

104.52

9.7

2.0

7.0

—

titre

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

66.87

95.50

6.4

1.8

4688.3

—

titre

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

16.94

41.24

7.4

2.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

17.16

40.89

7.3

1.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

10.46

31.03

3.1

1.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

114

8.77

27.94

6.4

1.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

8.80

25.81

5.1

1.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

109

7.91

24.69

5.9

1.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

100

7.17

21.44

5.6

1.8

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

107

5.91

16.88

16.2

6.0

1.0

mmol/l

0.34

(3011397) Hemoglobin [Presence] in Urine by Test strip

180

4.60

13.39

3.1

3.3

—

(42870588) Differential panel, method unspecified - Blood

259

4.45

12.86

9.6

5.8

—

(3044290) Cell count panel - Cerebral spinal fluid

11.17

10.64

1.2

1.0

—

(3018095) Leukocytes [#/volume] in Urine

279

3.58

9.42

4.3

3.0

29.8

144.7

e6/l

0.61

198

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

206

3.61

9.40

1.7

1.3

1.5

mmol/l

1.52

180

(40758558) Short blood count panel - Blood

203

3.53

9.07

11.8

6.9

—

(3022096) Basophils/100 leukocytes in Blood

367

3.62

9.01

12.8

6.2

0.9

0.7

2.78

342

(3006504) Eosinophils/100 leukocytes in Blood

372

3.54

8.71

12.8

6.3

3.2

2.8

0.34

350

(3019069) Monocytes/100 leukocytes in Blood

374

3.51

8.60

12.9

6.6

9.0

8.5

0.99

353

(3018010) Neutrophils/100 leukocytes in Blood

378

3.45

8.37

13.0

6.1

51.3

58.2

7.40

358

(3037467) Urinalysis macro (dipstick) panel - Urine

512

4.08

8.30

6.5

4.0

—

(3002030) Lymphocytes/100 leukocytes in Blood

385

3.35

7.98

12.8

6.3

34.3

26.7

7.70

363

(3015736) pH of Urine

311

3.20

7.83

3.6

3.2

—

(3001604) Monocytes [#/volume] in Blood

399

3.17

7.25

12.6

6.3

0.6

e9/l

0.52

352

(3006315) Basophils [#/volume] in Blood

400

3.15

7.20

12.6

6.3

0.0

e9/l

0.34

353

(3019198) Lymphocytes [#/volume] in Blood

408

3.05

6.80

12.6

6.4

2.2

1.8

e9/l

3.14

366

(3021589) Normoblasts [#/volume] in Blood

350

2.80

6.15

13.9

9.5

0.0

e9/l

0.50

290

(3013650) Neutrophils [#/volume] in Blood by Automated count

479

2.76

5.36

13.5

10.7

3.3

4.4

e9/l

6.53

420

(3016018) Differential panel - Cerebral spinal fluid

14.28

5.17

1.1

1.0

—

(3023410) Appearance of Cerebral spinal fluid

9.72

4.89

1.1

1.2

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

10.70

4.60

1.1

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

6.92

4.08

1.2

1.1

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

6.92

4.08

1.3

1.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

260

2.20

3.66

1.7

1.8

88.7

95.2

pmol/l

0.41

125

(3011288) Drugs identified in Urine by Screen method

3.85

3.59

2.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

168

2.31

3.51

6.1

1.9

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.73

3.44

1.6

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

128

2.38

3.28

2.7

1.7

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

143

2.31

3.25

3.1

3.0

130.1

94.7

ng/l

0.11

110

(3052851) Hemolysis interference index of Serum or Plasma

4.82

3.19

1.9

4.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

130

2.33

3.16

3.6

2.3

0.6

1.6

e6/l

—

(36660697) Celiac disease serology panel - Serum

2.77

3.04

1.1

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

6.99

2.91

1.2

1.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

142

2.22

2.90

3.6

2.3

1.6

1.1

e6/l

—

(3028707) Methadone [Presence] in Urine by Screen method

4.24

2.62

1.6

2.4

—

(3002256) Pathology report gross observation

2.22

2.28

1.1

1.2

—

(3030467) Casts [#/volume] in Urine by Automated count

230

1.86

2.23

3.7

2.5

0.1

0.4

e6/l

1.38

168

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

4.48

2.18

1.2

1.5

—

(3002385) Erythrocyte distribution width [Ratio]

689

2.01

2.16

24.1

16.3

13.1

13.5

1.93

680

(3042936) Bacteria identified in Isolate by Culture

112

2.10

2.16

1.5

2.8

—

(36304419) Bacteria [Presence] in Urine

224

1.85

2.15

2.8

2.5

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

5.19

2.09

2.8

2.0

—

(3026782) Osmolality of Urine

152

1.95

2.09

3.2

2.5

629.9

568.6

mosm/kgh2o

0.69

128

(3034770) Mitochondria Ab [Titer] in Serum

4.18

2.07

1.0

1.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.24

2.06

2.4

1.6

—

(40761511) CBC panel - Blood by Automated count

892

0.52

1.93

13.2

12.2

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.80

1.92

5.4

24.8

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.33

1.91

1.0

1.1

—

(3002582) Erythrocytes [#/volume] in Urine

249

1.75

1.90

3.6

2.5

13.7

350.0

e6/l

0.69

188

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.64

1.79

1.9

1.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

272

1.69

1.74

3.6

2.8

—

(1761868) Lipid panel - Serum or Plasma

360

0.57

1.63

2.2

2.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.41

1.59

1.3

1.2

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

2.21

1.56

1.1

4.2

66.8

70.9

ml/min/173m2

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

288

1.63

1.56

3.2

2.3

135.9

175.2

ug/l

0.39

271

(3009542) Hematocrit [Volume Fraction] of Blood

808

2.01

1.56

23.8

13.6

42.4

42.0

0.29

658

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

367

0.58

1.55

3.6

3.8

2.1

1.8

ug/l

0.19

332

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

790

1.88

1.44

17.7

12.5

85.0

87.3

ml/min/173m2

0.45

649

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.03

1.37

1.6

1.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.03

1.37

1.6

1.5

—

(3031040) Bacteria [#/volume] in Urine by Automated count

457

1.55

1.36

4.3

3.6

—

17.9

—

(3026008) Bacteria identified in Urine by Culture

175

1.65

1.29

3.4

2.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

167

1.65

1.28

2.0

2.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.87

1.27

1.5

2.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

834

1.89

1.26

13.7

13.6

27.1

24.2

mg/l

0.30

652

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.99

1.24

2.2

2.8

0.3

0.2

g/l

0.37

(3045414) Leukocytes [Presence] in Urine

0.00

1.18

0.0

1.7

—

(3020891) Body temperature

0.00

1.16

0.0

5.3

—

(3000991) Gas panel - Venous blood

1.92

1.14

5.4

8.7

—

(3013512) EKG study

199

0.55

1.12

5.1

3.8

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.03

1.11

1.4

1.2

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.33

1.04

1.8

1.1

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

2.33

1.04

1.0

4.1

24.8

33.2

u/ml

—

(3016879) Cocaine [Presence] in Urine

1.96

1.03

1.9

1.7

—

(3027944) Amphetamines [Presence] in Urine

1.91

1.02

1.9

1.8

—

(3000764) Benzodiazepines [Presence] in Urine

1.91

1.02

1.9

1.8

—

(3028300) Cannabinoids [Presence] in Urine

1.87

0.99

1.9

1.7

—

(3027008) Opiates [Presence] in Urine

1.87

0.99

1.9

1.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

293

0.65

0.98

3.6

3.5

43.1

41.6

ng/l

0.02

191

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

600

1.45

0.96

3.5

3.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

153

1.56

0.96

1.3

2.2

2.5

g/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.91

0.96

2.0

1.8

—

(3044640) Blood type and Crossmatch panel - Blood

234

1.46

0.93

2.0

2.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

283

0.68

0.82

2.7

3.8

25.6

21.4

—

113

(40760892) CBC W Ordered Manual Differential panel - Blood

194

0.62

0.81

5.3

5.5

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.05

0.73

1.0

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.05

0.73

1.0

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.05

0.73

1.0

1.2

—

(21494755) Public health laboratory ask at order entry panel

155

0.61

0.73

1.3

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

222

0.67

0.71

4.7

2.7

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.76

0.71

1.0

—

(3012516) Albumin [Mass/volume] in Urine

204

1.37

0.62

3.6

3.2

72.1

37.9

mg/l

0.23

131

(3008898) HLA-B27 [Presence]

1.66

0.56

1.0

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

700

1.32

0.56

3.9

4.1

1.8

1.9

mu/l

0.80

636

(3003694) ABO and Rh group [Type] in Blood

208

1.33

0.55

1.5

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.59

0.55

5.3

7.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

301

0.78

0.46

4.8

3.2

—

(3012544) pH of Venous blood

1.50

0.46

6.1

3.9

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

546

1.23

0.44

2.9

3.6

14.0

14.8

pmol/l

1.71

493

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.54

0.42

1.0

1.2

—

(3018418) pH of Serum or Plasma

207

1.27

0.42

5.2

3.6

—

7.4

—

(3012501) Base excess in Blood by calculation

0.00

0.41

0.0

1.6

—

2.8

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.41

0.0

1.6

—

8.9

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.41

0.0

1.6

—

5.2

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.41

0.0

1.7

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.36

0.41

6.6

2.6

4.4

4.9

kpa

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.40

0.0

1.9

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.40

0.0

1.1

—

(3000492) Spirometry study

112

0.69

0.40

1.6

1.5

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.31

0.38

6.7

3.6

5.6

5.8

kpa

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

133

0.73

0.36

1.8

1.7

479.2

443.0

pmol/l

—

118

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

346

1.20

0.35

3.8

4.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.35

0.34

1.3

1.7

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.32

0.33

1.3

1.2

40.0

234.1

u/ml

—

(3032080) INR in Blood by Coagulation assay

291

1.20

0.31

4.9

6.4

1.1

1.2

inr

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

1.35

0.31

3.6

3.8

266.3

257.0

u/l

0.07

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

129

0.75

0.30

1.6

1.9

—

(40768804) Tissue Pathology biopsy report

293

1.18

0.29

1.5

1.7

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

132

1.25

0.28

2.1

2.3

2.0

1.5

0.86

124

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.67

0.27

1.6

1.5

—

(3026493) Urate [Moles/volume] in Serum or Plasma

210

0.83

0.25

1.9

2.4

370.9

5765.1

umol/l

1.04

178

(3044889) 12 lead EKG panel

556

0.87

0.25

3.0

3.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

220

1.18

0.24

4.6

3.8

12.3

4.9

mg/mmol

0.29

146

(3010813) Leukocytes [#/volume] in Blood

947

1.36

0.23

25.1

19.3

6.6

6.7

e9/l

0.19

926

(3024731) MCV [Entitic volume]

947

1.36

0.23

25.0

19.2

91.4

90.4

1.34

934

(3026361) Erythrocytes [#/volume] in Blood

947

1.36

0.23

25.0

19.2

4.6

4.7

e12/l

1.02

925

(3000963) Hemoglobin [Mass/volume] in Blood

947

1.36

0.23

25.1

19.3

142.0

141.7

g/l

0.05

933

(3007461) Platelets [#/volume] in Blood

946

1.38

0.23

25.1

19.2

245.9

245.5

e9/l

0.03

927

(3035941) MCH [Entitic mass]

946

1.38

0.23

25.0

19.1

30.9

30.3

2.22

933

(3016502) Oxygen saturation in Arterial blood

1.29

0.23

4.9

14.8

97.7

96.3

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.5

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.21

0.0

2.5

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

3.6

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

9.6

—

0.6

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

2.4

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

2.4

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.1

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

2.4

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

2.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

2.4

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

2.4

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.21

0.0

4.3

—

4.5

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.21

0.0

1.7

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.3

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

1.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

4.1

—

3.6

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.21

0.0

4.5

—

56.3

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.6

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.1

—

1.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

16.5

—

1136.9

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

11.0

—

692.4

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.21

0.20

1.0

1.3

—

(3000494) Fungus identified in Specimen by Culture

100

1.23

0.19

1.3

1.6

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

110

1.21

0.18

1.2

1.0

7.2

u/ml

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.78

0.16

8.3

3.1

—

(3022145) Colonoscopy Study observation

1.11

0.15

1.6

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

104

1.17

0.13

1.3

1.5

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

125

0.87

0.11

1.1

1.2

52.2

29.3

iu/ml

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.12

0.10

5.8

6.3

24.2

25.4

mmol/l

—

(3022621) pH of Urine by Test strip

1.07

0.09

2.2

2.1

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.80

0.08

1.2

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

151

1.07

0.03

2.1

1.5

—

(3023368) Bacteria identified in Blood by Culture

222

1.05

0.02

5.7

4.9

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

205

0.97

0.00

2.3

2.5

0.8

0.7

ug/l

0.27

108

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

8.4

—

(4027681)

0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(4024509)

0.00

0.0

1.4

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.4

—

86.6

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.95

0.00

1.8

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.5

—

(4146454)

0.00

0.0

4.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

3.0

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.6

—

36.9

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.3

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.2

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.0

—

(3040370) OLANZapine [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

137.5

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.3

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(1002224) Polysomnography panel

0.92

0.00

1.0

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.00

0.00

1.6

1.7

—

(3000012) Reticulocyte production index

0.00

0.0

2.2

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

4.5

—

20.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.3

—

201.7

—

(3014043) Spermatozoa Nonprogressive/100 spermatozoa in Semen

0.00

0.0

5.7

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

2.3

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

1.9

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.4

—

(3038769) Chlamydophila pneumoniae IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

24.5

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.8

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.7

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.0

1.5

—

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.94

0.00

1.6

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1889.2

—

(40768797) Stomach Pathology biopsy report

0.93

0.00

1.1

1.3

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

2.9

—

14.6

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.4

—

141.3

—

(4211845)

0.00

0.0

1.4

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(40761995) Spermatozoa Progressive [#/volume] in Semen

0.00

0.0

2.8

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.2

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.6

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.7

—

13.0

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

1.5

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

3.6

—

33.8

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

1.5

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.5

—

210.8

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.4

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.1

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_SYPHILIS_NOS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_SYPHILIS_NOS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_SYPHILIS_NOS – Other and unspecified syphilis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other and unspecified syphilis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints