No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
111 |
4. Check minimum number of eventsNone |
111 |
5. Include endpointsNone |
111 |
6. Filter based on genotype QC (FinnGen only) |
94 |
Control definitions (FinnGen only)
- Control exclude
- AB1_SEXUAL_TRANSMISSION
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Other and unspecified syphilis
based on the number of shared cases.
Similar with more cases:
- Other and unspecified syphilis
- Syphilis
- Syphilis
- Infections with a predominantly sexual mode of transmission
- Infections with a predominantly sexual mode of transmission
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 893 | 369 | 469 |
| Only index persons | 694 | 310 | 384 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 42.22 | 37.40 | 47.04 |
| Only index persons | 40.34 | 35.56 | 44.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 94 | 25 | 69 |
| Unadjusted period prevalence (%) | 0.03 | 0.01 | 0.03 |
| Median age at first event (years) | 46.08 | 42.09 | 47.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 111
- Matched controls
- 1110
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A53.9
ICD-10 Finland
Syphilis, unspecified
+∞
84.5
70
*
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
30.6
65.0
50
29
WW200
NOMESCO Finland
Immunization
38.5
59.5
40
16
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
175.1
36.2
36
*
A53.0
ICD-10 Finland
Latent syphilis, unspecified as early or late
+∞
30.6
28
*
A56.3
ICD-10 Finland
Chlamydial infection of anus and rectum
+∞
21.6
20
*
B24
ICD-10 Finland
Unspecified human immunodeficiency virus [HIV] disease
90.4
20.5
22
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
9.0
20.2
29
42
A51.0
ICD-10 Finland
Primary genital syphilis
+∞
19.3
18
*
Z2221
NOMESCO Finland
Medical doctor
5.3
17.1
53
162
A51.9
ICD-10 Finland
Early syphilis, unspecified
+∞
16.0
15
*
Y25
ICPC
Fear sexually transm disease male
20.0
13.6
20
12
Z3231
NOMESCO Finland
Registered nurse
4.3
12.8
53
196
A54.5
ICD-10 Finland
Gonococcal pharyngitis
+∞
12.7
12
*
Z21
ICD-10 Finland
Asymptomatic human immunodeficiency virus [HIV] infection status
145.8
12.7
13
*
09710
ICD-8 Finland
Other syphilis and not specified, Latent syphilis, unspecified
+∞
11.7
11
*
A54.6
ICD-10 Finland
Gonococcal infection of anus and rectum
+∞
10.6
10
*
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
44.3
10.2
12
*
Z71.8
ICD-10 Finland
Other specified counselling
3.6
9.9
51
212
A54.0
ICD-10 Finland
Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess
+∞
9.5
9
*
Z25.1
ICD-10 Finland
Need for immunization against influenza
10.9
9.2
17
18
B23.8
ICD-10 Finland
HIV disease resulting in other specified conditions
97.1
8.5
9
*
A52.1
ICD-10 Finland
Symptomatic neurosyphilis
+∞
8.4
8
*
A51.3
ICD-10 Finland
Secondary syphilis of skin and mucous membranes
+∞
8.4
8
*
TAB00
NOMESCO Finland
Lumbar puncture
8.0
8.2
18
26
Z29.2
ICD-10 Finland
Other prophylactic chemotherapy
73.9
6.5
7
*
A52.2
ICD-10 Finland
Asymptomatic neurosyphilis
+∞
6.3
6
*
Y70
ICPC
Syphilis male
+∞
6.3
6
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.2
6.3
30
115
ZX114
NOMESCO Finland
Intramuscular
13.6
6.2
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
44
17.79
46.85
6.9
2.1
—
—
—
0
0
46
42
18.00
46.51
6.8
1.9
—
—
—
0
0
56
121
8.32
28.11
5.6
2.0
—
—
—
0
0
51
111
7.65
25.05
5.1
1.9
—
—
—
0
0
43
114
5.52
16.33
16.2
5.9
0.96
1.00
mmol/l
0.53
43
106
53
221
3.68
10.34
1.7
1.7
1.29
1.47
mmol/l
1.01
53
192
70
406
2.96
7.06
3.5
3.3
0.00
0.00
estimate
—
5
77
70
406
2.96
7.06
6.1
4.7
0.00
0.00
estimate
—
5
75
80
507
3.07
6.72
12.7
11.1
3.41
4.34
e9/l
3.63
73
443
9
10
9.67
4.88
1.1
1.1
—
—
—
0
0
47
279
2.19
3.83
1.7
1.8
90.13
95.46
pmol/l
0.35
24
132
28
137
2.40
3.56
3.5
2.4
1.24
1.58
e6/l
—
8
69
29
150
2.26
3.24
3.4
2.3
1.74
1.04
e6/l
—
9
82
12
35
3.72
3.22
1.8
1.3
—
—
—
0
0
28
148
2.19
2.95
3.1
3.0
130.14
92.92
ng/l
0.12
22
114
6
10
6.27
2.73
1.2
1.0
—
—
—
0
0
39
244
1.92
2.59
3.7
2.5
0.13
0.42
e6/l
1.46
27
179
44
287
1.88
2.57
3.4
2.8
—
—
—
0
0
90
756
2.01
2.18
23.2
16.0
13.11
14.58
%
8.44
90
747
5
10
5.18
2.09
2.8
2.0
—
—
—
0
0
6
15
4.16
2.07
1.2
1.5
—
—
—
0
0
8
29
2.89
1.83
2.4
1.6
—
—
—
0
0
96
845
2.01
1.73
17.0
12.3
85.26
88.00
ml/min/173m2
0.61
83
696
43
311
1.62
1.63
3.1
2.3
131.03
170.39
ug/l
0.43
43
294
27
389
0.60
1.52
4.1
3.9
2.15
1.83
ug/l
0.31
22
352
99
891
2.03
1.51
13.5
13.2
29.70
24.18
mg/l
0.63
77
691
12
61
2.08
1.39
1.1
4.1
66.83
70.50
ml/min/173m2
—
6
30
5
17
3.03
1.37
1.6
1.5
—
—
—
0
0
5
17
3.03
1.37
1.6
1.5
—
—
—
0
0
26
177
1.61
1.22
1.9
2.4
—
—
—
0
0
75
644
1.51
1.19
3.6
3.1
—
—
—
0
0
12
67
1.89
1.09
2.2
2.7
0.25
0.23
g/l
0.37
12
60
5
22
2.33
1.04
1.0
4.1
24.80
33.18
u/ml
—
5
22
83
741
1.48
0.97
3.9
4.1
1.76
1.92
mu/l
0.90
78
674
67
577
1.41
0.95
2.9
3.6
13.97
14.81
pmol/l
1.95
60
522
23
312
0.67
0.92
3.3
3.4
40.74
46.83
ng/l
0.11
14
206
8
45
1.84
0.86
1.4
1.2
—
—
—
0
0
8
46
1.80
0.84
1.0
1.0
—
—
—
0
0
10
58
1.80
0.82
2.0
1.8
—
—
—
0
0
7
40
1.80
0.73
3.6
2.7
22.00
24.72
mmol/l
—
7
40
23
299
0.71
0.72
3.1
3.9
25.87
21.13
%
0.55
12
120
5
28
1.82
0.67
1.0
1.2
—
—
—
0
0
5
28
1.82
0.67
1.0
1.2
—
—
—
0
0
6
104
0.55
0.65
5.3
7.7
—
—
—
0
0
28
230
1.29
0.49
4.4
3.8
12.33
5.22
mg/mmol
0.28
19
154
18
140
1.34
0.45
2.1
2.2
1.87
1.48
%
0.76
13
132
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
11
142
0.75
0.33
1.7
1.7
479.27
442.66
pmol/l
0.22
11
125
104
1012
1.44
0.32
24.3
19.1
4.62
4.69
e12/l
0.98
104
988
104
1012
1.44
0.32
24.4
19.1
142.11
141.61
g/l
0.12
104
997
104
1011
1.45
0.32
24.4
19.1
247.34
245.78
e9/l
0.11
104
990
41
371
1.17
0.28
2.7
2.6
—
—
—
0
0
9
74
1.24
0.26
6.7
3.5
5.59
5.84
kpa
—
9
74
11
88
1.28
0.23
3.6
3.7
266.27
254.96
u/l
0.08
11
83
19
219
0.84
0.23
1.9
2.4
369.89
5586.49
umol/l
1.03
19
184
19
164
1.19
0.22
2.2
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
11
133
0.81
0.21
1.5
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
29
319
0.88
0.20
4.3
3.3
—
—
—
0
0
6
52
1.16
0.19
1.0
1.3
—
—
—
0
0
91
885
1.16
0.18
5.5
3.8
1.35
1.37
mmol/l
0.14
86
820
11
130
0.83
0.17
1.1
1.2
52.16
28.88
iu/ml
—
5
40
7
88
0.78
0.15
7.1
3.1
—
—
—
0
0
13
115
1.15
0.11
1.2
1.2
1.00
8.73
u/ml
—
5
48
10
93
1.08
0.02
1.5
1.6
—
—
—
0
0
36
353
1.03
0.01
9.8
11.9
1.02
1.23
inr
—
8
116
10
98
1.02
0.00
1.5
1.7
—
—
—
0
0
5
49
1.02
0.00
5.8
6.0
24.20
25.16
mmol/l
—
5
49
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
9
90
1.00
-0.00
1.8
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.9
—
14.57
—
0
9
0
6
0.00
-0.00
0.0
1.3
—
201.67
—
0
6
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
6.4
—
141.25
—
0
8
22
220
1.00
-0.00
2.7
2.5
0.79
0.70
ug/l
0.26
14
116
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
11.75
—
0
6
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
210.83
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
36.86
—
0
5
0
8
0.00
-0.00
0.0
1.6
—
12.88
—
0
8
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
53.83
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
24.54
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
1843.17
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_SYPHILIS_NOS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have AB1_SYPHILIS_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: AB1_SYPHILIS_NOS – Other and unspecified syphilis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data