Other and unspecified syphilis

AB1_SYPHILIS_NOS_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 A53
  • Hospital discharge: ICD-10 A53
  • Hospital discharge: ICD-9 097
  • Hospital discharge: ICD-8 097
  • Cause of death: ICD-10 A53
  • Cause of death: ICD-9 097
  • Cause of death: ICD-8 097

3 out of 7 registries used, show all original rules.

144

4. Check minimum number of events

None

144

5. Include endpoints

None

144

6. Filter based on genotype QC (FinnGen only)

124

Control definitions (FinnGen only)

Control exclude
AB1_SEXUAL_TRANSMISSION

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF13

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 124 30 94
Unadjusted period prevalence (%) 0.04 0.01 0.04
Median age at first event (years) 44.84 38.74 46.79

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
144
Matched controls
1440
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A53.9
ICD-10 Finland
Syphilis, unspecified
+∞
118.7
97
*
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
33.5
96.2
74
44
WW200
NOMESCO Finland
Immunization
37.4
71.6
48
19
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
125.2
42.6
44
5
Y25
ICPC
Fear sexually transm disease male
14.6
34.9
35
31
A56.3
ICD-10 Finland
Chlamydial infection of anus and rectum
+∞
34.8
32
*
A51.0
ICD-10 Finland
Primary genital syphilis
+∞
33.7
31
*
A53.0
ICD-10 Finland
Latent syphilis, unspecified as early or late
+∞
32.5
30
*
B24
ICD-10 Finland
Unspecified human immunodeficiency virus [HIV] disease
71.3
21.6
24
*
A54.6
ICD-10 Finland
Gonococcal infection of anus and rectum
+∞
21.4
20
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
7.3
20.4
35
61
A51.9
ICD-10 Finland
Early syphilis, unspecified
+∞
19.2
18
*
A51.3
ICD-10 Finland
Secondary syphilis of skin and mucous membranes
+∞
19.2
18
*
A54.5
ICD-10 Finland
Gonococcal pharyngitis
217.1
19.0
19
*
Z2221
NOMESCO Finland
Medical doctor
4.7
18.5
63
203
Z3231
NOMESCO Finland
Registered nurse
4.4
17.3
67
236
A54.0
ICD-10 Finland
Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess
+∞
14.8
14
*
Z71.8
ICD-10 Finland
Other specified counselling
3.9
14.2
67
265
Z21
ICD-10 Finland
Asymptomatic human immunodeficiency virus [HIV] infection status
82.9
13.9
15
*
Y70
ICPC
Syphilis male
+∞
13.8
13
*
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
29.1
13.7
18
7
Z25.1
ICD-10 Finland
Need for immunization against influenza
10.2
12.7
25
29
09710
ICD-8 Finland
Other syphilis and not specified, Latent syphilis, unspecified
+∞
11.6
11
*
A63.0
ICD-10 Finland
Anogenital (venereal) warts
15.9
10.8
17
12
Z29.2
ICD-10 Finland
Other prophylactic chemotherapy
118.3
10.6
11
*
B23.8
ICD-10 Finland
HIV disease resulting in other specified conditions
106.8
9.5
10
*
B23.0
ICD-10 Finland
Acute HIV infection syndrome
+∞
9.5
9
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.4
9.2
41
151
A52.1
ICD-10 Finland
Symptomatic neurosyphilis
+∞
8.4
8
*
WX110, ,
SPAT
4.6
8.3
21
51
J01MA02
ATC
ciprofloxacin; systemic
2.8
8.3
64
319
TAB00
NOMESCO Finland
Lumbar puncture
7.1
8.0
19
30
UJF30
NOMESCO Finland
Ileoscopy through colon
4.3
7.6
21
55
A56.4
ICD-10 Finland
Chlamydial infection of pharynx
+∞
7.3
7
*
A53
ICD-10 Finland
Other and unspecified syphilis
+∞
7.3
7
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
6.8
38
158
ZX114
NOMESCO Finland
Intramuscular
11.8
6.4
11
10
A51.5
ICD-10 Finland
Early syphilis, latent
+∞
6.3
6
*
A52.9
ICD-10 Finland
Late syphilis, unspecified
+∞
6.3
6
*
A52.2
ICD-10 Finland
Asymptomatic neurosyphilis
+∞
6.3
6
*
Z76.0
ICD-10 Finland
Issue of repeat prescription
2.7
6.2
43
199
Z2446
NOMESCO Finland
Social worker
4.2
6.2
17
44

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
93
29
88.72
156.17
9.3
2.0
10.46
—
titre
—
48
0
44
11
57.16
74.72
2.9
2.1
31.01
34.08
%
0.28
44
11
78
119
13.12
55.39
3.4
1.7
—
—
—
0
0
83
181
9.46
42.11
5.5
1.6
—
—
—
0
0
58
121
7.35
29.29
5.0
1.7
—
—
—
0
0
51
138
5.17
18.58
16.2
5.5
0.96
1.00
mmol/l
0.73
51
129
68
237
4.54
17.93
3.0
3.3
—
—
—
0
0
81
350
4.00
15.31
4.1
3.0
27.63
219.28
e6/l
0.90
44
243
67
262
3.91
14.50
10.7
6.8
—
—
—
0
0
113
690
3.96
11.30
5.9
3.7
—
—
—
0
0
62
270
3.28
10.76
6.1
1.9
—
—
—
0
0
85
450
3.17
10.47
3.3
3.1
6.17
5.90
ph
—
9
49
93
555
2.91
8.63
12.0
6.8
0.18
0.20
e9/l
0.29
86
499
90
530
2.86
8.53
5.7
4.3
0.00
0.00
estimate
—
6
101
90
535
2.82
8.29
3.3
3.1
0.00
0.01
estimate
—
6
103
96
596
2.83
8.03
4.2
5.3
6.32
6.73
mmol/l
1.44
90
558
100
641
2.83
7.74
12.9
10.5
3.41
4.29
e9/l
3.96
87
563
87
521
2.69
7.70
9.5
6.4
—
—
—
0
0
89
543
2.67
7.52
12.3
6.2
0.56
0.59
e9/l
0.86
82
481
89
544
2.67
7.48
12.3
6.1
0.04
0.04
e9/l
0.02
82
482
14
16
9.56
7.24
1.1
1.1
—
—
—
0
0
12
10
12.95
7.22
1.2
1.2
—
—
—
0
0
80
471
2.57
7.17
13.6
8.7
0.00
0.00
e9/l
0.62
67
383
39
162
2.93
6.96
2.9
2.3
2.08
1.74
e6/l
0.10
11
83
89
560
2.54
6.80
12.4
6.3
2.08
1.87
e9/l
1.90
82
506
54
273
2.56
6.55
2.5
2.5
—
—
—
0
0
15
24
6.84
6.36
1.2
1.1
—
—
—
0
0
15
25
6.57
6.19
1.3
1.1
—
—
—
0
0
10
8
13.31
6.18
1.1
1.1
—
—
—
0
0
57
308
2.41
5.89
3.1
2.4
18.17
292.07
e6/l
0.70
42
234
42
203
2.51
5.47
2.3
1.6
—
—
—
0
0
13
22
6.38
5.36
1.1
1.1
12.00
3.80
e6/l
—
8
15
13
22
6.38
5.36
1.1
1.1
73.25
449.27
e6/l
—
8
15
52
281
2.33
5.28
3.3
2.4
0.10
0.43
e6/l
2.17
36
206
18
56
3.53
5.09
5.7
2.4
—
—
—
0
0
57
340
2.12
4.41
1.8
1.7
93.25
96.60
pmol/l
0.23
29
167
39
200
2.30
4.38
3.1
2.4
628.27
578.35
mosm/kgh2o
0.67
33
172
37
186
2.33
4.34
2.9
2.9
133.25
123.90
ng/l
0.03
28
137
12
27
4.75
4.04
2.3
3.5
—
—
—
0
0
21
90
2.56
3.44
1.0
1.1
—
—
—
0
0
119
982
2.22
3.32
21.6
14.7
13.17
14.47
%
8.91
119
967
34
185
2.10
3.24
1.4
1.4
21.38
20.94
nmol/l
0.08
28
156
50
313
1.92
3.22
3.1
3.0
8.18
9.10
mmol/l
0.54
45
273
17
68
2.70
3.18
2.0
1.9
—
—
—
0
0
13
41
3.38
3.15
2.0
2.2
—
—
—
0
0
28
151
2.06
2.71
1.5
2.7
—
—
—
0
0
23
116
2.17
2.64
1.1
1.2
—
—
—
0
0
18
83
2.34
2.53
1.9
1.8
—
—
—
0
0
18
85
2.28
2.41
1.9
1.8
—
—
—
0
0
39
246
1.80
2.38
1.4
1.2
0.70
1.24
u/ml
—
6
73
18
87
2.22
2.28
1.9
1.8
—
—
—
0
0
18
87
2.22
2.28
1.9
1.8
—
—
—
0
0
128
1136
2.14
2.21
12.5
12.4
31.72
23.32
mg/l
1.37
104
892
79
616
1.63
2.16
4.0
3.5
—
28.25
—
0
8
13
57
2.41
2.04
1.3
1.2
—
—
—
0
0
17
86
2.11
1.94
2.0
1.8
—
—
—
0
0
5
12
4.27
1.84
1.0
1.4
—
—
—
0
0
11
47
2.45
1.82
5.7
19.4
—
—
—
0
0
43
299
1.62
1.81
1.8
2.3
—
—
—
0
0
28
175
1.74
1.74
1.7
1.7
2.33
3.09
mg/l
1.01
22
152
5
13
3.94
1.73
2.0
2.8
—
—
—
0
0
16
83
2.04
1.72
5.1
8.0
—
—
—
0
0
27
168
1.75
1.71
1.5
1.5
—
—
—
0
0
7
26
2.78
1.60
1.0
1.3
—
—
—
0
0
36
498
0.63
1.59
2.2
2.5
—
—
—
0
0
33
222
1.63
1.57
3.1
2.5
—
—
—
0
0
33
222
1.63
1.57
1.3
1.3
2.34
2.36
g/l
0.04
15
150
8
33
2.51
1.56
1.5
1.2
—
—
—
0
0
21
125
1.80
1.54
1.4
1.8
—
—
—
0
0
12
61
2.06
1.37
1.3
1.2
89.88
202.54
u/ml
1.22
12
51
8
34
2.43
1.31
1.0
1.1
—
—
—
0
0
35
471
0.66
1.31
3.6
3.7
1.94
1.69
ug/l
0.30
30
431
8
37
2.23
1.23
1.1
1.4
—
—
—
0
0
39
290
1.47
1.19
1.4
1.4
—
—
—
0
0
114
1227
0.66
1.14
10.9
11.0
—
—
—
0
0
106
949
1.44
1.12
4.2
4.0
1.81
1.90
mu/l
0.41
101
874
7
31
2.32
1.12
1.0
1.3
—
—
—
0
0
9
47
1.97
1.04
3.1
2.6
21.33
24.53
mmol/l
—
9
47
86
752
1.36
0.99
3.1
3.4
14.13
14.74
pmol/l
1.48
78
684
34
257
1.42
0.95
3.4
3.2
74.32
289.99
mg/l
0.39
22
175
14
86
1.70
0.95
2.1
2.5
0.26
0.23
g/l
0.55
14
78
6
27
2.27
0.94
1.0
3.6
26.67
30.44
u/ml
—
6
27
18
120
1.57
0.90
1.3
1.6
—
—
—
0
0
34
260
1.40
0.89
4.3
3.5
—
7.40
—
0
50
18
258
0.65
0.89
4.2
3.4
—
—
—
0
0
6
31
1.98
0.85
1.7
1.7
—
—
—
0
0
0
25
0.00
0.80
0.0
1.8
—
—
—
0
0
30
382
0.73
0.78
3.4
3.2
35.08
44.21
ng/l
0.21
17
238
5
23
2.21
0.77
1.0
1.3
273.40
226.45
u/ml
—
5
11
15
100
1.56
0.76
4.5
12.7
96.79
96.55
%
0.11
15
94
5
25
2.03
0.73
1.0
1.4
—
—
—
0
0
13
85
1.58
0.72
5.0
3.5
—
—
—
0
0
7
42
1.70
0.69
1.3
1.3
—
—
—
0
0
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
0
22
0.00
0.60
0.0
1.7
—
5.09
—
0
22
0
22
0.00
0.60
0.0
1.7
—
8.65
—
0
22
0
22
0.00
0.60
0.0
1.7
—
2.50
—
0
14
0
23
0.00
0.59
0.0
1.1
—
—
—
0
0
33
273
1.27
0.52
4.5
4.9
—
—
—
0
0
17
222
0.73
0.52
1.4
1.4
—
—
—
0
0
43
370
1.23
0.49
1.7
1.8
—
—
—
0
0
5
82
0.60
0.47
1.6
1.3
—
—
—
0
0
33
277
1.25
0.47
4.4
3.7
10.90
5.50
mg/mmol
0.25
23
188
12
87
1.41
0.44
5.3
3.3
5.55
5.82
kpa
0.43
12
87
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
4.3
—
4.13
—
0
16
8
60
1.35
0.41
1.8
2.1
—
—
—
0
0
0
17
0.00
0.41
0.0
2.1
—
—
—
0
0
0
17
0.00
0.41
0.0
2.5
—
—
—
0
0
0
17
0.00
0.41
0.0
4.4
—
55.53
—
0
17
0
17
0.00
0.41
0.0
4.9
—
—
—
0
0
5
36
1.40
0.38
1.0
1.2
—
—
—
0
0
13
168
0.75
0.38
1.1
1.2
45.13
26.40
iu/ml
—
6
48
118
1134
1.22
0.37
5.4
3.6
1.37
1.37
mmol/l
0.01
111
1058
27
316
0.82
0.36
3.3
2.5
—
—
—
0
0
10
73
1.40
0.35
5.5
2.4
4.28
4.90
kpa
—
10
73
12
155
0.75
0.35
1.5
1.4
—
—
—
0
0
6
44
1.38
0.35
1.2
1.1
—
—
—
0
0
135
1323
1.33
0.28
23.0
17.5
142.35
142.72
g/l
0.11
135
1306
135
1323
1.33
0.28
22.9
17.4
90.86
90.06
fl
1.21
135
1307
135
1322
1.34
0.28
22.9
17.4
30.67
30.26
pg
1.74
135
1306
135
1322
1.34
0.28
23.0
17.4
248.20
245.87
e9/l
0.20
135
1293
8
65
1.24
0.27
1.3
1.6
—
—
—
0
0
34
304
1.16
0.26
2.5
3.2
2.32
2.35
mmol/l
0.76
29
268
78
740
1.12
0.23
2.8
3.5
—
—
—
0
0
13
107
1.24
0.22
1.5
1.4
—
—
—
0
0
122
1190
1.17
0.22
6.6
4.2
2.83
2.89
mmol/l
0.34
117
1108
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
2.9
—
—
—
0
0
0
12
0.00
0.21
0.0
3.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
246.08
—
0
13
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
3.9
—
3.50
—
0
14
0
14
0.00
0.20
0.0
1.6
—
16.18
—
0
5
14
164
0.84
0.19
1.6
1.6
458.79
431.87
pmol/l
0.16
14
147
6
52
1.16
0.19
1.0
1.1
—
—
—
0
0
120
1174
1.13
0.17
6.4
3.9
1.29
1.36
mmol/l
1.13
114
1099
5
68
0.73
0.17
1.2
3.3
—
—
—
0
0
8
70
1.15
0.16
1.3
1.2
—
—
—
0
0
120
1175
1.13
0.16
6.3
3.9
4.55
4.71
mmol/l
1.17
114
1107
6
77
0.77
0.16
2.5
4.5
—
—
—
0
0
8
100
0.79
0.14
1.8
1.6
—
—
—
0
0
11
95
1.17
0.12
1.4
1.4
—
—
—
0
0
26
279
0.92
0.10
1.7
2.2
370.15
6745.07
umol/l
1.24
26
239
8
73
1.10
0.07
1.0
1.1
—
—
—
0
0
45
434
1.05
0.07
8.8
11.5
1.03
1.21
inr
—
8
140
13
121
1.08
0.04
1.2
1.2
—
—
—
0
0
26
269
0.96
0.03
2.5
2.4
0.71
0.69
ug/l
0.07
17
134
14
147
0.95
0.01
1.1
1.2
1.13
8.75
u/ml
—
6
64
27
268
1.01
0.00
2.7
3.2
0.00
0.01
estimate
—
5
99
23
225
1.03
0.00
2.1
1.6
1.01
1.06
mg/l
0.06
16
169
0
6
0.00
0.00
0.0
2.2
—
3.53
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
8
80
1.00
0.00
1.3
2.1
6.16
6.54
ug/l
—
8
74
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
8.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.1
—
19.83
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.7
—
33.67
—
0
9
8
85
0.94
-0.00
1.8
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
0.35
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
1497.38
—
0
8
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
8
88
0.90
-0.00
5.3
5.6
9.76
8.38
mmol/l
—
8
83
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
7.90
—
0
9
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: AB1_SYPHILIS_NOS_WIDE – Other and unspecified syphilis

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).