Bradycardia, unspecified, drug-induced

BRADY_UNSPE

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ATC codes for adverse effects of Drugs — ANY Hospital discharge: ICD-10 — R00.1# 1 out of 7 registries used, show all original rules.	101
4. Check minimum number of events None	101
5. Include endpoints None	101
6. Filter based on genotype QC (FinnGen only)	101

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	BRADY_UNSPE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC	ANY
HD_ICD_10	R001
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Bradycardia, unspecified, drug-induced based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	101	46	55
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	62.85	60.29	64.99

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
89: Matched controls
890

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

R00.1

ICD-10 Finland

Bradycardia, unspecified

+∞

113.1

XFP20

NOMESCO Finland

Check up of cardiac pacemaker

10.4

12.5

FPE30

NOMESCO Finland

Replacement of transvenous cardiac pacemaker pulse generator

35.5

12.1

Z45.0

ICD-10 Finland

Adjustment and management of cardiac devices

17.0

11.6

Z95.0

ICD-10 Finland

Presence of electronic cardiac devices

9.9

11.3

I49.5

ICD-10 Finland

Sick sinus syndrome

8.8

8.1

Initial pacemaker installation

49.4

7.9

I44.2

ICD-10 Finland

Atrioventricular block, complete

12.4

7.0

FPE20

NOMESCO Finland

Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes

8.2

6.2

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

114

2.06

2.07

3.7

2.7

2.4

2.0

e6/l

0.13

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

142

1.91

1.86

1.6

1.9

2.2

1.6

mg/l

0.33

116

(3015377) Calcium [Moles/volume] in Serum or Plasma

251

1.75

1.85

3.4

3.7

2.4

2.3

mmol/l

1.46

217

(3008898) HLA-B27 [Presence]

3.99

1.73

1.0

1.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

122

1.91

1.71

3.7

2.5

1.5

0.8

e6/l

0.39

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.22

1.68

1.8

2.7

32.6

32.8

u/l

—

(3000330) Specific gravity of Urine by Test strip

2.63

1.63

11.6

4.0

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

190

1.74

1.62

2.2

2.1

2.9

3.0

mg/l

0.04

165

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

149

1.80

1.60

2.9

3.1

2.5

mmol/l

0.69

135

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

292

1.61

1.47

2.1

2.3

84.1

90.1

pmol/l

0.27

153

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

284

1.61

1.45

2.1

2.4

75.0

77.2

nmol/l

0.20

244

(3052851) Hemolysis interference index of Serum or Plasma

2.52

1.42

2.1

4.8

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

1.37

0.0

1.8

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

1.36

0.0

1.9

—

(1761868) Lipid panel - Serum or Plasma

174

1.67

1.33

4.5

3.3

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.87

1.30

1.6

1.8

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.71

1.23

1.2

1.4

—

(3022313) Gas panel - Capillary blood

0.00

1.18

0.0

2.8

—

(3026782) Osmolality of Urine

165

1.60

1.10

3.7

2.9

653.1

539.9

mosm/kgh2o

1.20

143

(3022621) pH of Urine by Test strip

2.00

1.05

3.2

3.6

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.01

0.99

1.4

2.7

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.98

0.0

2.9

—

25.8

—

(3023368) Bacteria identified in Blood by Culture

232

1.49

0.98

3.5

4.5

—

(3032080) INR in Blood by Coagulation assay

317

1.43

0.94

15.7

9.9

1.5

1.3

inr

0.44

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.21

0.93

3.2

2.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

262

1.45

0.92

4.1

3.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.98

0.91

3.0

7.6

—

(36660697) Celiac disease serology panel - Serum

2.06

0.88

1.2

1.1

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

323

1.39

0.83

4.6

4.7

35.1

34.2

g/l

0.45

299

(3002582) Erythrocytes [#/volume] in Urine

240

1.42

0.81

4.4

3.2

21.9

333.1

e6/l

0.61

184

(3030467) Casts [#/volume] in Urine by Automated count

213

1.44

0.80

4.5

3.1

0.2

0.6

e6/l

1.27

164

(3012501) Base excess in Blood by calculation

0.00

0.80

0.0

4.1

—

2.9

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.80

0.0

4.1

—

5.0

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.80

0.0

4.1

—

8.0

—

(3044889) 12 lead EKG panel

451

1.37

0.79

4.6

4.5

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.78

0.0

2.3

—

0.2

—

(3013512) EKG study

214

0.65

0.77

6.1

4.5

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.14

0.75

16.8

4.5

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.89

0.69

1.0

1.1

—

(40768443) Skin Pathology biopsy report

1.89

0.69

1.4

1.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

479

1.33

0.67

3.4

4.5

13.7

14.2

mm/h

0.07

438

(3042936) Bacteria identified in Isolate by Culture

105

1.50

0.64

1.9

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

240

1.36

0.64

5.6

4.6

—

(3012544) pH of Venous blood

1.57

0.63

3.0

3.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

326

1.32

0.62

2.6

2.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

463

1.30

0.62

5.9

4.7

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.61

0.0

1.3

—

1.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

178

1.38

0.60

5.8

3.8

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.59

0.0

1.4

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.59

0.0

1.4

—

(3019150) Specific gravity of Urine by Refractometry

125

1.43

0.58

3.5

5.3

1.0

kg/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.53

0.57

1.2

1.3

16.6

49.0

iu/ml

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

301

1.30

0.57

3.4

3.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.58

0.57

1.3

2.9

—

(3044640) Blood type and Crossmatch panel - Blood

226

1.33

0.56

2.3

2.1

—

(3000991) Gas panel - Venous blood

1.52

0.55

3.0

8.6

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

460

1.27

0.52

4.3

3.8

15.0

pmol/l

0.05

397

(40758558) Short blood count panel - Blood

173

1.35

0.52

3.3

7.5

—

(3048689) Calprotectin [Mass/mass] in Stool

1.42

0.52

2.3

2.1

158.7

244.7

ug/g

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

363

1.27

0.51

4.7

6.7

1.2

mmol/l

0.55

302

(3003694) ABO and Rh group [Type] in Blood

142

0.67

0.50

1.2

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

575

1.25

0.47

5.0

4.7

2.0

mu/l

0.05

498

(3026008) Bacteria identified in Urine by Culture

233

1.28

0.45

5.2

3.6

—

(3000494) Fungus identified in Specimen by Culture

1.46

0.45

1.3

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

193

0.74

0.44

3.7

4.0

5.7

7.5

mg/mmol

—

122

(3012516) Albumin [Mass/volume] in Urine

181

0.74

0.42

2.9

3.2

9501.7

386.2

mg/l

—

120

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.41

0.0

2.4

—

1.8

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.41

0.0

1.6

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.41

0.0

1.1

—

(40768793) Breast Pathology biopsy report

0.00

0.41

0.0

1.3

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.2

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.4

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.6

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.40

0.0

1.2

—

0.2

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.40

0.0

1.7

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

531

1.22

0.39

7.3

7.7

74.7

83.1

u/l

0.99

494

(3020630) Protein [Mass/volume] in Serum or Plasma

1.43

0.38

1.3

3.0

65.5

66.1

g/l

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

191

1.26

0.38

3.1

4.3

27.9

22.0

—

(36304419) Bacteria [Presence] in Urine

210

1.25

0.37

3.8

3.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

167

1.25

0.31

2.0

2.1

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

198

1.21

0.28

3.3

3.1

32.8

32.0

u/l

0.07

183

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

586

0.87

0.25

20.5

16.7

76.1

72.5

ml/min/173m2

0.67

477

(3007853) Bacteria identified in Skin by Aerobe culture

1.31

0.25

1.0

1.7

—

(3015736) pH of Urine

249

1.17

0.24

5.2

4.0

—

(3025941) Bacteria identified in Stool by Culture

1.33

0.23

1.4

1.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.25

0.22

1.4

1.9

2.5

g/l

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.2

—

(44790047)

0.00

0.21

0.0

1.5

—

(44806118)

0.00

0.21

0.0

1.5

—

(44790049)

0.00

0.21

0.0

1.5

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

1.8

—

31.8

—

(3012441) Differential panel - Pleural fluid

0.00

0.21

0.0

1.4

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.21

0.0

2.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.21

0.0

1.2

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(44790048)

0.00

0.21

0.0

1.5

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.21

0.0

1.3

—

232.4

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3045788) Cell count panel - Pleural fluid

0.00

0.21

0.0

1.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

5.4

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

2.6

—

90.7

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

2.6

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

3.1

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3028308) Erythrocytes [#/volume] in Pleural fluid

0.00

0.21

0.0

1.3

—

10214.3

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

146

1.20

0.21

3.3

4.4

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.21

0.0

1.4

—

(40768800) Prostate Pathology biopsy report

0.00

0.20

0.0

1.0

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.19

0.20

1.2

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

641

1.13

0.19

21.8

18.1

32.4

26.7

mg/l

0.43

528

(3013650) Neutrophils [#/volume] in Blood by Automated count

383

1.12

0.17

6.4

9.0

4.4

4.5

e9/l

0.05

326

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.14

0.16

1.6

1.7

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

140

1.17

0.16

2.6

3.0

1.3

0.9

ug/l

—

100

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.23

0.16

3.3

3.6

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

108

0.82

0.13

1.7

5.4

0.9

1.0

mmol/l

—

(3009542) Hematocrit [Volume Fraction] of Blood

548

1.09

0.12

26.1

19.4

36.6

38.7

0.64

360

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.16

0.11

1.5

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

145

0.88

0.10

1.5

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.15

0.09

1.5

1.9

—

(40761535) Cells panel - Urine sediment

1.10

0.09

2.5

4.1

—

(3019060) Gas panel - Arterial blood

1.04

0.08

3.0

4.4

—

(4035726)

0.77

0.08

1.0

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.12

0.08

1.3

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.82

0.08

1.5

1.8

406.3

384.6

nmol/l

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

616

0.94

0.08

5.3

5.1

2.7

2.5

mmol/l

0.45

545

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

605

1.06

0.07

4.3

4.9

5.9

6.0

mmol/l

0.36

536

(3022217) INR in Platelet poor plasma by Coagulation assay

109

1.11

0.06

35.8

27.5

—

1.5

—

(40761511) CBC panel - Blood by Automated count

657

1.06

0.05

20.2

16.1

—

(42870588) Differential panel, method unspecified - Blood

238

1.07

0.05

3.3

5.3

—

(40768797) Stomach Pathology biopsy report

100

1.11

0.05

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

318

1.06

0.05

6.5

4.6

24.7

48.9

ng/l

1.93

245

(3006315) Basophils [#/volume] in Blood

322

0.95

0.05

4.3

5.9

0.0

e9/l

0.87

277

(3001604) Monocytes [#/volume] in Blood

321

0.95

0.04

4.3

5.8

0.6

e9/l

0.05

275

(3020564) Creatinine [Moles/volume] in Serum or Plasma

659

1.05

0.04

26.1

21.2

79.3

84.8

umol/l

0.96

659

(40760892) CBC W Ordered Manual Differential panel - Blood

121

1.09

0.04

4.7

6.0

—

(40768804) Tissue Pathology biopsy report

252

1.04

0.02

2.1

2.2

—

(3019198) Lymphocytes [#/volume] in Blood

328

0.96

0.02

4.2

5.9

1.7

e9/l

0.02

289

(3013115) Eosinophils [#/volume] in Blood

332

0.99

0.00

4.2

6.2

0.2

e9/l

0.13

287

(3021589) Normoblasts [#/volume] in Blood

285

1.02

0.00

10.3

11.4

0.0

e9/l

0.50

232

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.0

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.3

—

14.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.3

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.0

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.0

—

90.1

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

2.0

—

(4146454)

0.00

0.0

3.0

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

0.0

2.2

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

1.8

—

6.8

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.7

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

0.00

0.0

8.5

—

13.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

1.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.84

0.00

1.2

1.5

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.2

—

(3001467) Alkaline phosphatase.bone [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.0

—

44.3

—

(3000492) Spirometry study

1.02

0.00

1.5

1.4

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

1.7

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(4024509)

0.00

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.1

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(4306422)

0.00

0.0

1.0

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

94.8

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.3

—

13.9

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.4

—

(3000012) Reticulocyte production index

0.00

0.0

1.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.2

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3022145) Colonoscopy Study observation

0.86

0.00

1.2

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.00

0.00

1.6

1.9

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

807.2

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.2

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

2.8

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3016038) Potassium [Moles/volume] in Urine

0.00

0.0

1.2

—

35.7

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.7

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.8

—

71.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.90

0.00

1.3

1.5

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.0

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

290.0

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.7

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(4062490)

0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

2.1

—

5.8

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

106.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.97

0.00

1.3

1.5

—

(3002256) Pathology report gross observation

0.96

0.00

1.1

1.3

—

(40761536) Microorganisms panel - Urine sediment

0.97

0.00

4.5

4.3

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: BRADY_UNSPE – Bradycardia, unspecified, drug-induced

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Bradycardia, unspecified, drug-induced

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Bradycardia, unspecified, drug-induced (BRADY_UNSPE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints