Bradycardia, unspecified, drug-induced

BRADY_UNSPE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ATC codes for adverse effects of Drugs — ANY Hospital discharge: ICD-10 — R00.1# 1 out of 7 registries used, show all original rules.	101
4. Check minimum number of events None	101
5. Include endpoints None	101
6. Filter based on genotype QC (FinnGen only)	98

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	BRADY_UNSPE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC	ANY
HD_ICD_10	R001
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Bradycardia, unspecified, drug-induced based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	98	45	53
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	62.80	60.22	64.99

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
101: Matched controls
1010

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

R00.1

ICD-10 Finland

Bradycardia, unspecified

+∞

129.9

101

Z95.0

ICD-10 Finland

Presence of electronic cardiac devices

9.9

20.2

XFP20

NOMESCO Finland

Check up of cardiac pacemaker

7.1

15.5

FPE30

NOMESCO Finland

Replacement of transvenous cardiac pacemaker pulse generator

16.7

10.9

Z45.0

ICD-10 Finland

Adjustment and management of cardiac devices

9.7

9.9

Initial pacemaker installation

61.0

9.9

I49.5

ICD-10 Finland

Sick sinus syndrome

7.7

9.1

XF404

NOMESCO Finland

Ambulatory ECG

5.1

8.9

XFP02, ,

NOMESCO Finland

+∞

6.3

R07.4

ICD-10 Finland

Chest pain, unspecified

2.9

6.0

186

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

114

2.06

2.07

3.7

2.7

2.43

1.99

e6/l

0.13

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

142

1.91

1.86

1.6

1.9

2.17

1.60

mg/l

0.33

116

(3015377) Calcium [Moles/volume] in Serum or Plasma

251

1.75

1.85

3.4

3.7

2.38

2.34

mmol/l

1.33

220

(3008898) HLA-B27 [Presence]

3.99

1.73

1.0

1.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

122

1.91

1.71

3.7

2.5

1.51

0.76

e6/l

0.39

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.22

1.68

1.8

2.7

32.63

32.78

u/l

—

(3000330) Specific gravity of Urine by Test strip

2.63

1.63

11.5

4.0

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

190

1.74

1.62

2.2

2.1

2.92

2.97

mg/l

0.04

165

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

149

1.80

1.60

2.9

3.1

2.49

2.46

mmol/l

0.70

135

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

292

1.61

1.47

2.1

2.3

84.07

90.08

pmol/l

0.27

153

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

284

1.61

1.45

2.1

2.4

75.04

77.24

nmol/l

0.20

244

(3052851) Hemolysis interference index of Serum or Plasma

2.52

1.42

2.1

4.8

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

1.37

0.0

1.8

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

1.36

0.0

1.9

—

(1761868) Lipid panel - Serum or Plasma

174

1.67

1.33

4.5

3.3

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.87

1.30

1.6

1.8

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.71

1.23

1.2

1.4

—

(3022313) Gas panel - Capillary blood

0.00

1.18

0.0

2.8

—

(3022621) pH of Urine by Test strip

2.00

1.05

3.2

3.6

—

(3026782) Osmolality of Urine

169

1.55

1.00

4.5

3.0

646.44

534.59

mosm/kgh2o

1.16

148

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.01

0.99

1.4

2.7

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.98

0.0

2.9

—

25.76

—

(3023368) Bacteria identified in Blood by Culture

232

1.49

0.98

3.5

4.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

364

1.43

0.95

23.5

17.5

1.53

1.42

inr

0.23

106

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.21

0.93

3.2

2.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

262

1.45

0.92

4.0

3.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.98

0.91

3.0

7.6

—

(36660697) Celiac disease serology panel - Serum

2.06

0.88

1.2

1.1

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

323

1.39

0.83

4.6

4.7

35.10

34.24

g/l

0.45

299

(3002582) Erythrocytes [#/volume] in Urine

240

1.42

0.81

4.4

3.2

21.93

333.07

e6/l

0.61

184

(3030467) Casts [#/volume] in Urine by Automated count

213

1.44

0.80

4.5

3.1

0.23

0.63

e6/l

1.27

164

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.80

0.0

4.1

—

8.03

—

(3012501) Base excess in Blood by calculation

0.00

0.80

0.0

4.1

—

2.88

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.80

0.0

4.1

—

4.98

—

(3044889) 12 lead EKG panel

451

1.37

0.79

4.6

4.5

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.78

0.0

2.3

—

0.18

—

(3013512) EKG study

214

0.65

0.77

6.1

4.5

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.14

0.75

16.8

4.5

—

(40768443) Skin Pathology biopsy report

1.89

0.69

1.4

1.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.89

0.69

1.0

1.1

—

(3013707) Erythrocyte sedimentation rate by Westergren method

479

1.33

0.67

3.4

4.5

13.72

14.17

mm/h

0.07

438

(3042936) Bacteria identified in Isolate by Culture

105

1.50

0.64

1.9

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

240

1.36

0.64

5.6

4.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

326

1.32

0.62

2.6

2.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

463

1.30

0.62

5.9

4.6

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.61

0.0

1.3

—

1.14

—

(3041096) Erythrocytes [Presence] in Urine by Automated

178

1.38

0.60

5.8

3.8

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.59

0.0

1.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.59

0.0

1.4

—

(3019150) Specific gravity of Urine by Refractometry

125

1.43

0.58

3.5

5.3

1.02

kg/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.53

0.57

1.2

1.3

16.60

47.65

iu/ml

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

577

1.30

0.57

5.0

4.7

2.07

1.99

mu/l

0.16

500

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

301

1.30

0.57

2.3

2.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.58

0.57

1.3

2.9

—

(3044640) Blood type and Crossmatch panel - Blood

226

1.33

0.56

2.3

2.1

—

(3000991) Gas panel - Venous blood

1.52

0.55

2.9

8.6

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

100

1.46

0.55

4.4

7.4

103.93

103.59

mmol/l

0.06

100

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

460

1.27

0.52

4.3

3.8

14.98

15.03

pmol/l

0.05

397

(40758558) Short blood count panel - Blood

173

1.35

0.52

3.3

7.5

—

(3048689) Calprotectin [Mass/mass] in Stool

1.42

0.52

2.3

2.1

158.67

244.67

ug/g

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

363

1.27

0.51

4.7

6.7

1.22

1.21

mmol/l

0.49

304

(3003694) ABO and Rh group [Type] in Blood

142

0.67

0.50

1.2

1.3

—

(3000494) Fungus identified in Specimen by Culture

1.46

0.45

1.3

1.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

193

0.74

0.44

3.3

3.8

5.68

7.46

mg/mmol

—

122

(3012516) Albumin [Mass/volume] in Urine

181

0.74

0.42

2.9

3.2

9501.68

386.21

mg/l

—

120

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.41

0.0

2.4

—

1.85

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

0.41

0.0

1.3

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.41

0.0

1.1

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.41

0.0

1.6

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.4

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.40

0.0

1.7

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.40

0.0

1.2

—

0.23

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.6

—

(3026008) Bacteria identified in Urine by Culture

237

1.25

0.39

5.2

3.6

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

531

1.22

0.39

7.3

7.7

74.68

83.11

u/l

0.99

494

(3020630) Protein [Mass/volume] in Serum or Plasma

1.43

0.38

1.3

3.0

65.54

66.06

g/l

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

191

1.26

0.38

3.1

4.3

27.90

21.96

—

(36304419) Bacteria [Presence] in Urine

210

1.25

0.37

3.8

3.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

167

1.25

0.31

2.0

2.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

589

0.85

0.28

20.6

16.7

76.13

72.61

ml/min/173m2

0.64

480

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

198

1.21

0.28

3.3

3.1

32.83

32.04

u/l

0.07

183

(3007853) Bacteria identified in Skin by Aerobe culture

1.31

0.25

1.0

1.7

—

(3025941) Bacteria identified in Stool by Culture

1.33

0.23

1.4

1.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

1.25

0.22

1.4

1.93

2.50

g/l

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.21

0.0

2.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3012441) Differential panel - Pleural fluid

0.00

0.21

0.0

1.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

1.8

—

31.82

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

0.21

0.0

1.5

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.21

0.0

1.2

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.21

0.0

1.3

—

232.42

—

(3045788) Cell count panel - Pleural fluid

0.00

0.21

0.0

1.3

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

5.4

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

3.1

—

(3028308) Erythrocytes [#/volume] in Pleural fluid

0.00

0.21

0.0

1.3

—

10214.29

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

2.61

—

(3000012) Reticulocyte production index

0.00

0.21

0.0

1.9

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

2.6

—

90.69

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

146

1.20

0.21

3.3

4.4

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.21

0.0

1.4

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.4

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.2

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.4

—

(40768800) Prostate Pathology biopsy report

0.00

0.20

0.0

1.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.19

0.20

1.2

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

641

1.13

0.19

21.8

18.1

32.35

26.71

mg/l

0.43

528

(3013650) Neutrophils [#/volume] in Blood by Automated count

383

1.12

0.17

6.4

9.0

4.41

4.49

e9/l

0.05

326

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.14

0.16

1.6

1.7

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

140

1.17

0.16

2.6

3.0

1.25

0.89

ug/l

—

100

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.23

0.16

3.3

3.6

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

108

0.82

0.13

1.7

5.4

0.90

1.01

mmol/l

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.16

0.11

1.5

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

145

0.88

0.10

1.5

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.15

0.09

1.5

1.9

—

(40761535) Cells panel - Urine sediment

1.10

0.09

2.2

4.1

—

(3019060) Gas panel - Arterial blood

1.04

0.08

3.0

4.4

—

(4035726) Immunohistochemistry procedure

0.77

0.08

1.0

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.12

0.08

1.3

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.82

0.08

1.5

1.8

406.33

384.63

nmol/l

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

616

0.94

0.08

5.3

5.1

2.67

2.54

mmol/l

0.45

545

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

605

1.06

0.07

4.3

4.9

5.91

6.03

mmol/l

0.36

536

(3009542) Hematocrit [Volume Fraction] of Blood

693

0.94

0.06

30.5

25.7

38.11

39.05

0.40

641

(40761511) CBC panel - Blood by Automated count

657

1.06

0.05

20.2

16.1

—

(40768797) Stomach Pathology biopsy report

100

1.11

0.05

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

318

1.06

0.05

6.5

4.6

24.65

48.95

ng/l

1.94

245

(3006315) Basophils [#/volume] in Blood

322

0.95

0.05

4.3

5.9

0.05

0.04

e9/l

0.87

277

(3001604) Monocytes [#/volume] in Blood

321

0.95

0.04

4.3

5.8

0.61

0.62

e9/l

0.05

276

(3020564) Creatinine [Moles/volume] in Serum or Plasma

659

1.05

0.04

26.1

21.2

79.30

84.81

umol/l

0.96

659

(40760892) CBC W Ordered Manual Differential panel - Blood

301

1.04

0.03

4.6

6.6

—

(40768804) Tissue Pathology biopsy report

252

1.04

0.02

2.1

2.2

—

(3019198) Lymphocytes [#/volume] in Blood

328

0.96

0.02

4.2

6.0

1.70

1.71

e9/l

0.03

290

(3013115) Eosinophils [#/volume] in Blood

332

0.99

0.00

4.2

6.2

0.21

0.20

e9/l

0.13

287

(3021589) Normoblasts [#/volume] in Blood

285

1.02

0.00

10.3

11.4

0.00

e9/l

0.50

232

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.0

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.2

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3002256) Pathology report gross observation

0.96

0.00

1.1

1.3

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.3

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

2.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.2

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.3

—

14.38

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.0

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(4146454) Self-monitoring of blood glucose

0.00

0.0

3.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.0

—

90.08

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.00

-0.00

1.6

1.9

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

-0.00

0.0

2.8

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

-0.00

0.0

2.0

—

39.08

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3016038) Potassium [Moles/volume] in Urine

0.00

-0.00

0.0

1.2

—

35.67

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

8.5

—

13.12

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.1

—

5.80

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.2

—

(3045424) Erythrocytes [Presence] in Urine

0.00

-0.00

0.0

1.4

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

1.8

—

71.23

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

106.20

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

1.7

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.0

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

-0.00

0.0

2.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3020013) Alkaline phosphatase.intestinal [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

20.00

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.90

-0.00

1.3

1.5

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

290.00

—

(3045716) Anion gap in Serum or Plasma

0.00

-0.00

0.0

1.8

—

6.78

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.1

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3001467) Alkaline phosphatase.bone [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

44.33

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

807.20

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

-0.00

0.0

1.3

—

13.86

—

(3035880) pH of Pleural fluid

0.00

-0.00

0.0

1.2

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3022145) Colonoscopy Study observation

0.86

-0.00

1.2

1.3

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

2.2

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

1.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.84

-0.00

1.2

1.5

—

(40761536) Microorganisms panel - Urine sediment

0.97

-0.00

4.5

4.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.97

-0.00

1.3

1.5

—

(3000492) Spirometry study

1.00

-0.00

1.5

1.4

—

(3047189) Immunofixation for 24 hour Urine

0.00

-0.00

0.0

1.7

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

1.7

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

1.0

—

94.80

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

2.7

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: BRADY_UNSPE – Bradycardia, unspecified, drug-induced

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

R13

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Bradycardia, unspecified, drug-induced

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Bradycardia, unspecified, drug-induced (BRADY_UNSPE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints