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Symptoms and signs involving the circulatory and respiratory systems

R18_SYMPTOMS_SIGNS_INVOLVI_CIRCULATO_RESPI_SYSTEMS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 R00-R09
  • Cause of death: ICD-10 R00-R09

2 out of 7 registries used, show all original rules.

160591

4. Check minimum number of events

None

160591

5. Include endpoints

161207

6. Filter based on genotype QC (FinnGen only)

161207

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
R
Name in latin
Symptomata et signa ad systema circulatorium et systema respiratorium pertinentia

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 161207 88660 72547
Unadjusted period prevalence (%) 31.01 30.22 31.98
Median age at first event (years) 56.06 54.17 58.37

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2271
Matched controls
12173
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R06.0
ICD-10 Finland
Dyspnoea
16.2
323.0
652
295
R07.4
ICD-10 Finland
Chest pain, unspecified
17.3
323.0
680
293
R06.5
ICD-10 Finland
Mouth breathing
17.2
138.8
268
94
R06.2
ICD-10 Finland
Wheezing
37.7
108.5
170
26
R03AC02
ATC
salbutamol; inhalant
2.8
104.0
1179
3415
R05
ICD-10 Finland
Cough
5.4
97.8
361
409
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.6
93.6
560
1022
R00.2
ICD-10 Finland
Palpitations
9.1
91.2
232
150
R04.0
ICD-10 Finland
Epistaxis
32.6
88.7
143
25
A02BC02
ATC
pantoprazole; systemic
2.6
81.9
960
2709
R07.3
ICD-10 Finland
Other chest pain
8.9
76.9
197
128
R00.0
ICD-10 Finland
Tachycardia, unspecified
15.6
75.6
150
55
J01AA02
ATC
doxycycline; systemic
2.2
65.1
1215
4166
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.2
60.0
225
253
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
58.9
748
2107
R06.4
ICD-10 Finland
Hyperventilation
65.9
57.9
83
7
J45.9
ICD-10 Finland
Asthma, unspecified
3.7
56.9
309
502
C07AB07
ATC
bisoprolol; oral
3.2
55.3
359
669
R01.0
ICD-10 Finland
Benign and innocent cardiac murmurs
132.7
53.6
72
*
N02AX02
ATC
tramadol; systemic, rectal
2.5
52.4
539
1344
A02BC05
ATC
esomeprazole; systemic
2.4
48.7
524
1333
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.1
46.0
317
612
N02BE01
ATC
paracetamol; systemic, rectal
2.0
45.0
1547
6346
R51.80
ICD-10 Finland
Headache
2.7
44.6
368
800
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
4.0
42.1
202
291
R07.0
ICD-10 Finland
Pain in throat
4.1
40.8
188
261
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.5
39.2
165
209
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
9.2
39.1
97
59
H02AB06
ATC
prednisolone; systemic
2.0
38.5
656
2030
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
9.3
38.3
94
56
R01AD09
ATC
mometasone; nasal
1.9
38.1
899
3144
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.8
37.1
288
598
N05AH04
ATC
quetiapine; oral
2.3
36.4
425
1106
R53
ICD-10 Finland
Malaise and fatigue
2.4
35.1
386
974
G47.3
ICD-10 Finland
Sleep apnoea
3.0
35.0
238
451
XF404
NOMESCO Finland
Ambulatory ECG
5.6
34.7
118
117
J01DB01
ATC
cefalexin; oral
1.8
34.4
1635
7107
N03AX16
ATC
pregabalin; oral
2.8
33.8
254
515
M03BX02
ATC
tizanidine; oral
1.8
33.5
1061
4035
N05BA04
ATC
oxazepam; oral
2.2
33.4
427
1157
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
32.6
1199
4765
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
32.4
344
850
C07AA05
ATC
propranolol; systemic
2.2
32.3
396
1050
M79.6
ICD-10 Finland
Pain in limb
2.0
32.2
511
1517
R02
ICPC
Shortness of breath/dyspnoea
3.4
31.8
182
304
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.7
31.6
256
544
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
31.4
767
2666
R09.1
ICD-10 Finland
Pleurisy
17.4
30.4
57
18
R00.1
ICD-10 Finland
Bradycardia, unspecified
41.0
29.5
45
6
R42
ICD-10 Finland
Dizziness and giddiness
2.6
28.9
248
543
R03AK07
ATC
formoterol and budesonide; inhalant
2.4
28.5
296
721
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.5
28.1
256
580
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
28.1
934
3542
R04.2
ICD-10 Finland
Haemoptysis
23.9
28.1
48
11
N02AJ06
ATC
codeine and paracetamol; systemic
1.8
28.0
619
2065
N06AX11
ATC
mirtazapine; oral
1.9
27.8
498
1539
R01AD08
ATC
fluticasone; nasal
1.8
27.3
586
1930
XF402
NOMESCO Finland
ECG with work load test
6.4
26.8
82
71
M01AH05
ATC
etoricoxib; oral
1.7
26.7
826
3053
R03BA05
ATC
fluticasone; inhalant
2.1
26.0
359
995
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
25.9
451
1373
J01FA10
ATC
azithromycin; systemic
1.6
25.9
1160
4743
R01AD12
ATC
fluticasone furoate; nasal
1.8
25.6
623
2132
M54.5
ICD-10 Finland
Low back pain
1.8
25.5
593
1999
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
25.5
401
1174
M03BC01
ATC
orphenadrine (citrate); systemic
2.0
24.9
404
1197
R03BA02
ATC
budesonide; inhalant
2.2
24.5
311
830
M01AB05
ATC
diclofenac; systemic, rectal
1.6
24.5
1024
4087
S06.0
ICD-10 Finland
Concussion
2.4
24.1
250
605
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
23.6
423
1298
I10
ICD-10 Finland
Essential (primary) hypertension
2.4
23.5
243
587
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.6
23.4
197
426
N06AB10
ATC
escitalopram; oral
1.9
23.3
468
1496
R50.9
ICD-10 Finland
Fever, unspecified
2.3
23.3
253
627
R03DC03
ATC
montelukast; oral
2.3
23.1
248
611
M01AE02
ATC
naproxen; oral, rectal
1.6
23.0
913
3575
R74
ICPC
Upper respiratory infection acute
1.6
22.7
771
2893
P01AB01
ATC
metronidazole; oral, rectal
1.7
22.1
546
1865
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
22.0
238
588
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.9
21.5
101
143
N06AB04
ATC
citalopram; systemic
2.0
21.4
340
994
XF400
NOMESCO Finland
ECG with 12 standard connections
3.0
21.2
141
263
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.1
21.0
279
758
J01CA04
ATC
amoxicillin; systemic
1.7
20.7
1821
8601
R03BA01
ATC
beclometasone; inhalant
2.4
20.7
210
502
G44.2
ICD-10 Finland
Tension-type headache
2.3
20.7
225
556
ZXE00
NOMESCO Finland
One hour or less
1.7
20.7
535
1847
M25.5
ICD-10 Finland
Pain in joint
1.9
20.7
382
1180
C09CA06
ATC
candesartan; oral
2.7
20.6
163
339
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
20.6
300
847
J01FA09
ATC
clarithromycin; systemic
1.8
20.5
460
1516
L01
ICPC
Neck symptom/complaint
2.3
20.5
229
574
R07.1
ICD-10 Finland
Chest pain on breathing
11.2
20.4
45
22
XG474
NOMESCO Finland
Exhalation nntrogen oxide
7.8
20.3
54
38
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.8
19.9
472
1582
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
19.6
272
750
UJF32
NOMESCO Finland
Coloscopy
2.3
19.6
216
539
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
19.5
283
797
SPAT1263
SPAT
Sampling
1.6
19.3
843
3337
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
19.3
330
991
J01FA06
ATC
roxithromycin; oral
1.7
19.2
591
2135
I49.3
ICD-10 Finland
Ventricular premature depolarization
5.0
19.1
70
77
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.8
19.0
136
266
C08CA01
ATC
amlodipine; oral
2.8
18.9
136
267
N06AB06
ATC
sertraline; oral
2.2
18.9
228
591
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
4.3
18.9
80
103
SPAT1312
SPAT
General health counselling
1.6
18.9
590
2141
R20.2
ICD-10 Finland
Paraesthesia of skin
3.2
18.8
115
201
M54.4
ICD-10 Finland
Lumbago with sciatica
2.2
18.7
220
565
K30
ICD-10 Finland
Functional dyspepsia
2.7
18.5
149
314
A11
ICPC
Chest pain NOS
4.2
18.5
80
105
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.8
18.5
70
80
SPAT1097
SPAT
Recording of ECG
2.9
18.5
130
252
GD1AA
SPAT
NA
2.5
18.4
161
355
N05CF01
ATC
zopiclone; oral
1.8
18.2
362
1143
J01MA02
ATC
ciprofloxacin; systemic
1.7
18.2
464
1587
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
3.0
18.1
117
214
R06.8
ICD-10 Finland
Other and unspecified abnormalities of breathing
14.0
18.0
36
14
R06AE07
ATC
cetirizine; oral
1.5
17.9
897
3648
SPAT1283
SPAT
Restricted health certificate
1.6
17.8
576
2103
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.2
17.7
105
179
N03AX12
ATC
gabapentin; oral
2.5
17.5
161
366
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
17.5
379
1231
A02BC03
ATC
lansoprazole; oral
1.9
17.4
285
839
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
17.4
371
1197
L03
ICPC
Low back symptom/complaint
1.8
17.4
383
1249
A02BC01
ATC
omeprazole; systemic
1.9
17.3
321
989
N01
ICPC
Headache
2.1
17.3
217
574
R03BA08
ATC
ciclesonide; inhalant
2.9
16.9
116
220
N06AX16
ATC
venlafaxine; oral
2.0
16.9
250
708
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
16.7
518
1864
R11
ICD-10 Finland
Nausea and vomiting
2.5
16.7
151
340
N05BA01
ATC
diazepam; systemic, rectal
2.3
16.6
177
434
C09AA05
ATC
ramipril; oral
3.1
16.6
105
190
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.5
16.3
55
55
R03.0
ICD-10 Finland
Elevated blood-pressure reading, without diagnosis of hypertension
4.3
16.3
69
89
R03AC03
ATC
terbutaline; inhalant
2.0
16.3
246
701
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
16.3
253
729
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
16.2
390
1307
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.6
16.1
134
288
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
16.1
437
1516
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.9
16.1
110
210
N02AA05
ATC
oxycodone; systemic
3.8
16.1
77
112
R4110
NOMESCO Finland
Physiotherapy
1.9
16.0
256
746
R01.1
ICD-10 Finland
Cardiac murmur, unspecified
16.3
15.9
30
10
SPAT1260
SPAT
Consultation of another employee
1.9
15.8
258
757
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.1
15.8
97
172
F51.0
ICD-10 Finland
Nonorganic insomnia
1.9
15.6
269
806
SPAT1310
SPAT
Counselling related to known health issue
1.6
15.6
515
1880
M79.1
ICD-10 Finland
Myalgia
2.1
15.5
210
572
XQ800
NOMESCO Finland
Prick test
2.4
15.5
146
337
N05AH03
ATC
olanzapine; systemic
2.3
15.4
162
395
SPAT1301
SPAT
No procedures
1.6
15.4
511
1869
A04
ICPC
Weakness/tiredness general
2.1
15.4
201
540
M54.2
ICD-10 Finland
Cervicalgia
2.9
15.3
104
197
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
7.1
15.2
42
32
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.4
15.1
143
329
Z2221
NOMESCO Finland
Medical doctor
1.7
14.9
362
1212
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
14.6
171
437
C03CA01
ATC
furosemide; systemic
2.2
14.5
175
454
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
14.5
1015
4366
R05
ICPC
Cough
1.7
14.5
325
1062
7862A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Cough
+∞
14.5
18
*
J45
ICD-10 Finland
Asthma
2.4
14.5
139
323
D01
ICPC
Abdominal pain/cramps general
2.1
14.5
191
516
J01FF01
ATC
clindamycin; systemic
1.7
14.5
390
1347
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
14.4
688
2733
J45.1
ICD-10 Finland
Nonallergic asthma
2.9
14.4
99
189
R21
ICPC
Throat symptom/complaint
1.6
14.4
541
2035
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
14.3
111
228
XG466
NOMESCO Finland
Sleep oxymetry
9.2
14.3
34
20
N06AX12
ATC
bupropion; oral
2.1
14.3
174
454
AA1AD
NOMESCO Finland
CT of head and brain
2.1
14.2
193
527
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.4
14.2
137
319
G43.9
ICD-10 Finland
Migraine, unspecified
2.4
14.2
135
313
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.6
14.1
71
108
D11
ICPC
Diarrhoea
1.8
14.0
275
860
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
13.9
292
932
J01MA12
ATC
levofloxacin; systemic
2.2
13.9
153
380
XG410
NOMESCO Finland
Flow-volume spirometry
6.2
13.8
42
37
L17
ICPC
Foot/toe symptom/complaint
1.8
13.8
265
825
R55
ICD-10 Finland
Syncope and collapse
2.4
13.4
127
292
I47.1
ICD-10 Finland
Supraventricular tachycardia
4.3
13.3
55
70
Z3231
NOMESCO Finland
Registered nurse
1.8
13.3
289
934
XG480
NOMESCO Finland
Histamine provocation of respiratroy tract
11.7
13.2
28
13
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
13.2
912
3888
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.0
13.2
47
51
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.3
13.1
72
118
S18
ICPC
Laceration/cut
1.6
13.0
469
1741
M01AC06
ATC
meloxicam; systemic, rectal
1.7
13.0
316
1058
R06AX27
ATC
desloratadine; oral
1.5
13.0
542
2082
J35.0
ICD-10 Finland
Chronic tonsillitis
2.0
13.0
185
514
A03FA01
ATC
metoclopramide; systemic, rectal
2.0
12.8
190
537
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
12.8
335
1143
P01
ICPC
Feeling anxious/nervous/tense
1.7
12.8
314
1052
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
12.7
162
431
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
12.7
1451
6766
J20
ICD-10 Finland
Acute bronchitis
2.4
12.6
114
257
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
12.5
301
1003
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.2
12.5
148
380
N06AX21
ATC
duloxetine; oral
2.2
12.5
137
340
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
6.1
12.5
38
34
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
12.4
592
2337
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
12.4
1904
9388
K80
ICPC
Cardiac arrhythmia NOS
3.4
12.3
67
109
A03
ICPC
Fever
1.6
12.2
409
1488
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
12.2
445
1654
Z71.8
ICD-10 Finland
Other specified counselling
1.6
12.1
407
1482
WX110
NOMESCO Finland
Local anesthesy
1.4
12.1
1391
6461
SPAT1240
SPAT
Therapeutic discussion
1.7
12.1
300
1008
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
12.1
171
474
N17
ICPC
Vertigo/dizziness
2.6
12.1
98
208
N06AB03
ATC
fluoxetine; oral
2.2
12.1
143
368
EMB10
NOMESCO Finland
Tonsillectomy
1.8
12.0
214
648
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.0
12.0
167
461
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
8.7
12.0
29
18
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
12.0
300
1010
I49.8
ICD-10 Finland
Other specified cardiac arrhythmias
5.7
12.0
38
36
ZX120
NOMESCO Finland
Intravenous
2.7
12.0
88
176
N03AX09
ATC
lamotrigine; oral
2.4
11.9
108
244
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.9
11.9
197
579
R07.2
ICD-10 Finland
Precordial pain
18.9
11.9
21
6
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
11.8
203
606
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
1.8
11.8
225
697
WX002
NOMESCO Finland
Sedation and analgesia
2.1
11.8
155
418
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.3
11.7
48
61
N05AX12
ATC
aripiprazole; systemic
2.2
11.7
138
354
DKW00
NOMESCO Finland
Cauterisation of mucosa of nose
32.4
11.6
18
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.4
11.5
110
255
R12
ICD-10 Finland
Heartburn
2.4
11.5
110
255
B01AA03
ATC
warfarin; systemic
2.5
11.5
97
210
TFP34
NOMESCO Finland
Electrophysiological investigation
5.4
11.5
38
38
C09CA01
ATC
losartan; oral
2.7
11.4
88
182
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.4
11.4
102
230
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.0
11.3
72
132
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
4.0
11.3
49
66
ZXD05
NOMESCO Finland
Urgent procedure
1.5
11.3
488
1881
R04.1
ICD-10 Finland
Haemorrhage from throat
+∞
11.3
14
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.3
11.3
109
256
R00.8
ICD-10 Finland
Other and unspecified abnormalities of heart beat
9.4
11.2
26
15
ENC30
NOMESCO Finland
Plastic operation of pharynx
18.0
11.2
20
6
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
11.1
154
423
C07AB02
ATC
metoprolol; systemic
2.1
11.1
138
364
I50.9
ICD-10 Finland
Heart failure, unspecified
2.6
11.0
90
193
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.7
11.0
80
160
J31.0
ICD-10 Finland
Chronic rhinitis
2.3
11.0
114
277
ZXA00
NOMESCO Finland
Right side
1.8
11.0
210
652
J02AC01
ATC
fluconazole; systemic
1.5
10.8
461
1771
J35.1
ICD-10 Finland
Hypertrophy of tonsils
2.9
10.8
72
136
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
3.1
10.8
67
120
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
1.8
10.7
222
705
U02
ICPC
Urinary frequency/urgency
2.1
10.7
129
335
R51
ICD-10 Finland
Headache
2.4
10.7
102
237
N03AE01
ATC
clonazepam; systemic
2.8
10.7
74
143
JN4BD
NOMESCO Finland
Extensive body CT
3.1
10.7
64
113
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.1
10.6
127
329
N05AX08
ATC
risperidone; systemic
2.0
10.6
141
382
J34.2
ICD-10 Finland
Deviated nasal septum
2.5
10.6
89
193
J01DA01
ATC
[U] cefalexin; systemic
1.4
10.6
1125
5103
R5140
NOMESCO Finland
Monitoring the use of the aid
2.8
10.6
74
144
F41.09
ICD-10 Finland
UNS Panic Syndrome
2.5
10.6
89
194
Z00.8
ICD-10 Finland
Other general examinations
2.1
10.5
134
357
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.9
10.5
164
473
J01CE02
ATC
phenoxymethylpenicillin; oral
1.4
10.5
1551
7422
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
1.9
10.4
167
488
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.4
10.4
54
86
ZY010
NOMESCO Finland
Hospital outpatient
2.3
10.3
100
234
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
4.6
10.3
39
46
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.0
10.3
150
422
N07BB01
ATC
disulfiram; oral
2.7
10.2
78
160
SPAT1058
SPAT
PEF monitoring instruction
2.4
10.2
94
214
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
3.9
10.2
45
62
M01AE03
ATC
ketoprofen; systemic, rectal
1.6
10.1
329
1185
I49.1
ICD-10 Finland
Atrial premature depolarization
5.3
10.1
34
35
N05CF02
ATC
zolpidem; oral
1.7
10.1
218
701
R03BB04
ATC
tiotropium bromide; inhalant
4.1
10.1
42
55
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.0
10.0
142
396
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
9.9
202
638
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
9.9
111
281
WX402
NOMESCO Finland
General anaesthesia
1.8
9.8
206
656
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
9.8
758
3253
W22
ICD-10 Finland
Striking against or struck by other object(s)
1.8
9.7
179
547
R52.0
ICD-10 Finland
Acute pain
3.0
9.7
62
114
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.6
9.7
266
916
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.9
9.7
147
420
SPAT1254
SPAT
Administration of medicine
1.9
9.6
163
485
M54
ICD-10 Finland
Dorsalgia
1.8
9.6
195
616
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
6.0
9.6
29
26
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
1.9
9.6
152
441
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
9.6
365
1365
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.0
9.5
125
338
R06AE09
ATC
levocetirizine; oral
1.6
9.5
267
926
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
2.3
9.5
93
221
R52.9
ICD-10 Finland
Pain, unspecified
2.1
9.5
114
296
T78.4
ICD-10 Finland
Allergy, unspecified
2.4
9.5
85
193
N06AA09
ATC
amitriptyline; systemic
2.9
9.4
61
114
X58
ICD-10 Finland
Exposure to other specified factors
1.6
9.4
296
1058
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.2
9.3
100
248
A01
ICPC
Pain general/multiple sites
2.3
9.3
91
216
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.6
9.2
72
150
Z3226
NOMESCO Finland
Physiotherapist
1.8
9.2
171
527
H03AA01
ATC
levothyroxine sodium; systemic
1.7
9.2
203
658
XX3DW
NOMESCO Finland
Time consuming IT work
3.0
9.2
56
101
H02AB04
ATC
methylprednisolone; systemic
2.0
9.1
122
332
K29.7
ICD-10 Finland
Gastritis, unspecified
4.0
9.1
39
53
F41.00
ICD-10 Finland
Moderate panic disorder
3.3
9.1
49
80
B01AC04
ATC
clopidogrel; oral
4.7
9.0
33
38
M01AH01
ATC
celecoxib; oral (coxibs)
2.1
8.9
104
267
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
3.3
8.9
48
78
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
12.1
8.8
18
8
XF600
NOMESCO Finland
Bloodpressure measurement
2.9
8.8
58
110
I51.4
ICD-10 Finland
Myocarditis, unspecified
5.1
8.8
30
32
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
8.8
138
401
A07AA02
ATC
nystatin; oral
3.5
8.7
43
66
ZYC01
NOMESCO Finland
Remote contact by phone
2.5
8.7
70
150
N05BA12
ATC
alprazolam; oral
2.0
8.7
119
328
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
3.2
8.6
49
84
H53.1
ICD-10 Finland
Subjective visual disturbances
2.4
8.6
75
168
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
2.9
8.6
56
105
E66.01
ICD-10 Finland
Obesity due to excess calories
2.0
8.6
114
309
UJF30
NOMESCO Finland
Ileoscopy through colon
2.1
8.6
102
265
WZC30
NOMESCO Finland
Teaching
2.1
8.6
106
280
J05AB01
ATC
aciclovir; systemic
1.6
8.6
270
963
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
2.4
8.6
76
171
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
1.7
8.6
182
585
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.3
8.5
84
201
D06
ICPC
Abdominal pain localized other
2.0
8.5
119
331
A10BA02
ATC
metformin; oral
1.9
8.5
141
418
J01
ICD-10 Finland
Acute sinusitis
2.4
8.5
78
179
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.1
8.5
99
256
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
4.7
8.4
31
36
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
8.4
190
619
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
8.4
81
191
R13
ICD-10 Finland
Dysphagia
3.1
8.4
48
83
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.1
8.4
96
245
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.1
8.3
102
268
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.2
8.3
91
227
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
4.9
8.3
29
32
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.7
8.2
58
116
TAB00
NOMESCO Finland
Lumbar puncture
2.6
8.2
61
126
L15
ICPC
Knee symptom/complaint
1.7
8.1
183
598
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.4
8.1
74
170
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
8.1
83
201
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
2.2
8.1
86
213
S93.4
ICD-10 Finland
Sprain and strain of ankle
1.6
8.1
255
909
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.0
8.1
112
310
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.4
8.1
71
160
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.3
8.0
76
178
K02
ICPC
Pressure/tightness of heart
5.6
8.0
25
24
D02
ICPC
Abdominal pain epigastric
2.3
8.0
80
193
R96
ICPC
Asthma
2.2
7.9
87
219
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.0
7.9
113
317
N03AG01
ATC
valproic acid; systemic, rectal
2.0
7.9
103
279
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.2
7.9
86
216
DHB50
NOMESCO Finland
Turbinoplasty
3.0
7.8
48
87
R29
ICPC
Respiratory symptom/complaint other
2.1
7.8
94
245
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.4
7.8
69
156
K02.1
ICD-10 Finland
Caries of dentine
1.3
7.8
1255
5938
L04
ICPC
Chest symptom/complaint
2.3
7.8
76
180
A05
ICPC
Feeling ill
1.9
7.8
117
335
N06AB05
ATC
paroxetine; oral
2.1
7.7
96
255
P99
ICPC
Psychological disorders other
2.2
7.7
81
200
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.7
7.6
35
51
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
5.0
7.6
26
28
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
7.6
46
82
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.3
7.6
75
179
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
2.4
7.6
68
155
L86
ICPC
Back syndrome with radiating pain
2.6
7.6
57
118
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.0
7.6
95
254
WX290
NOMESCO Finland
Other blockade of nerve
1.3
7.6
1081
5025
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
7.6
68
156
R09
ICPC
Sinus symptom/complaint
1.7
7.5
163
527
Z2445
NOMESCO Finland
Psychologist
2.3
7.5
72
169
C10AA07
ATC
rosuvastatin; oral
2.5
7.5
62
135
C05AA08
ATC
fluocortolone; rectal, topical
2.0
7.5
106
297
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.5
7.5
341
1319
I50.0
ICD-10 Finland
Congestive heart failure
3.2
7.5
42
72
ZXA05
NOMESCO Finland
Left side
1.6
7.5
190
642
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
2.1
7.5
92
244
XG405
NOMESCO Finland
Education on PEF monitoring
9.2
7.4
17
10
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
1.9
7.4
107
301
R03AK08
ATC
formoterol and beclometasone; inhalant
3.4
7.4
38
61
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.0
7.4
101
279
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.3
7.4
40
66
N30.9
ICD-10 Finland
Cystitis, unspecified
2.4
7.4
64
144
ZXA10
NOMESCO Finland
Bilateral
1.7
7.4
150
476
S60.2
ICD-10 Finland
Contusion of other parts of wrist and hand
2.0
7.4
93
249
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.3
7.4
662
2882
K59.09
ICD-10 Finland
Constipation, unspecified
3.6
7.3
35
53
M79.7
ICD-10 Finland
Fibromyalgia
3.6
7.3
35
53
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.5
7.3
60
130
F41.0
ICD-10 Finland
Panic disorder [episodic paroxysmal anxiety]
2.4
7.3
63
141
P06
ICPC
Sleep disturbance
1.7
7.2
157
508
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.1
7.2
82
210
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.8
7.2
129
393
B02AA02
ATC
tranexamic acid; systemic
1.9
7.2
109
312
N06BA04
ATC
methylphenidate; oral
2.1
7.2
86
225
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.3
7.2
70
166
Z2446
NOMESCO Finland
Social worker
2.1
7.2
88
233
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
7.2
125
378
B01AB05
ATC
enoxaparin; parenteral
1.6
7.1
203
706
UJD02
NOMESCO Finland
Gastroscopy
2.9
7.1
45
84
R01
ICPC
Pain respiratory system
4.1
7.1
29
38
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.4
7.1
466
1927
K04
ICPC
Palpitations/awareness of heart
2.5
7.1
59
128
N05AF03
ATC
chlorprothixene; systemic
3.1
7.1
41
72
J01MA14
ATC
moxifloxacin; systemic
2.3
7.1
69
163
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.0
7.1
43
77
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.8
7.1
47
90
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
3.2
7.1
39
66
C08CA13
ATC
lercanidipine; oral
3.8
7.0
31
44
R01AD11
ATC
triamcinolone; nasal
1.8
7.0
129
397
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.7
7.0
161
530
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
2.4
7.0
61
137
E66
ICD-10 Finland
Obesity
2.9
7.0
46
87
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
2.6
7.0
51
105
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
7.0
1015
4710
G54.0
ICD-10 Finland
Brachial plexus disorders
2.9
6.9
44
83
A02BC04
ATC
rabeprazole; oral
2.0
6.9
90
245
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.8
6.9
119
358
A06AD11
ATC
lactulose; oral
1.8
6.9
134
418
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.4
6.9
61
139
UDC00
NOMESCO Finland
Ear microscopy
2.0
6.9
95
263
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.1
6.9
28
37
OAA65
SPAT
NA
1.5
6.8
220
790
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.9
6.8
29
40
J34.1
ICD-10 Finland
Cyst and mucocele of nose and nasal sinus
3.3
6.8
35
57
J02.9
ICD-10 Finland
Acute pharyngitis, unspecified
1.8
6.7
123
378
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.9
6.7
96
270
K07.60
ICD-10 Finland
Snapping jaw
2.0
6.7
84
224
XKD00
NOMESCO Finland
Uroflowmetry
2.3
6.7
64
150
SBB10
NOMESCO Finland
Teeth copy
2.1
6.7
82
217
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.4
6.7
305
1181
G04CA02
ATC
tamsulosin; oral
1.9
6.7
101
290
C10AA01
ATC
simvastatin; oral
2.2
6.7
67
163
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.3
6.7
26
33
P29
ICPC
Psychological sympt/compl other
1.7
6.6
151
495
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
6.6
113
338
N06AX26
ATC
vortioxetine; oral
1.7
6.6
130
408
SPAT1130
SPAT
Esophagoscopy, gastroscopy and duodenoscopy
3.7
6.6
30
44
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.1
6.6
27
36
A29
ICPC
General symptom/complaint other
1.9
6.6
102
295
A04AA01
ATC
ondansetron; systemic, rectal
2.7
6.6
47
94
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
4.8
6.6
23
26
C03DA01
ATC
spironolactone; oral
2.4
6.6
56
125
XF640
NOMESCO Finland
NA
9.0
6.6
15
9
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.3
6.6
480
2019
R05FB02
ATC
cough suppressants and expectorants
1.4
6.6
363
1458
IBA03
NOMESCO Finland
Psychotherapy evaluation
3.9
6.5
28
39
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
6.5
508
2159
F90.0
ICD-10 Finland
Disturbance of activity and attention
1.8
6.5
105
311
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.2
6.4
65
158
C08CA05
ATC
nifedipine; systemic
2.5
6.4
53
117
R52.2
ICD-10 Finland
Other chronic pain
3.0
6.4
39
70
T82
ICPC
Obesity
2.5
6.4
50
107
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
1.6
6.4
192
678
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.0
6.4
86
238
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.4
6.4
285
1099
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
26.9
6.4
10
*
S89.9
ICD-10 Finland
Unspecified injury of lower leg
2.2
6.4
65
160
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
6.3
64
155
R33
ICD-10 Finland
Retention of urine
2.6
6.3
47
98
K03.66
ICD-10 Finland
Tooth plaque
2.1
6.3
73
189
C07AG02
ATC
carvedilol; oral
4.0
6.3
26
35
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
9.4
6.3
14
8
XFE00
NOMESCO Finland
Epicardial ultrasonography
5.7
6.3
19
18
M75.8
ICD-10 Finland
Other shoulder lesions
2.8
6.3
42
81
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.2
6.3
64
157
Z00.0
ICD-10 Finland
General medical examination
1.5
6.3
230
851
J46
ICD-10 Finland
Status asthmaticus
3.8
6.3
27
38
R07
ICPC
Sneezing/nasal congestion
1.6
6.3
155
520
T17.2
ICD-10 Finland
Foreign body in pharynx
7.2
6.2
16
12
UKC02
NOMESCO Finland
Cystoscopy
1.9
6.2
88
248
D10
ICPC
Vomiting
1.6
6.2
165
566
E66.8
ICD-10 Finland
Other obesity
2.4
6.2
54
123
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.2
6.2
34
58
SPAT1262
SPAT
Handing over of treatment supplies
1.7
6.2
142
469
JN3AD
NOMESCO Finland
Abdominal CT examination
2.2
6.1
61
148
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.5
6.1
191
682
B34.9
ICD-10 Finland
Viral infection, unspecified
2.2
6.1
65
162
WX872
NOMESCO Finland
Intensive care
3.0
6.1
36
65
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.1
6.1
69
177
SGC00
NOMESCO Finland
Local medication of root channels of tooth
1.5
6.1
207
752
M70.6
ICD-10 Finland
Trochanteric bursitis
2.8
6.1
41
80
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.2
6.1
62
151
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
10.0
6.0
13
7
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
1.7
6.0
133
434
W19
ICD-10 Finland
Unspecified fall
1.7
6.0
136
447

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: R18_SYMPTOMS_SIGNS_INVOLVI_CIRCULATO_RESPI_SYSTEMS – Symptoms and signs involving the circulatory and respiratory systems

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).