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Cardiac murmurs and other cardiac sounds

R18_CARDIAC_MURMU_OTHER_CARDIAC_SOUNDS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 R01
  • Cause of death: ICD-10 R01

2 out of 7 registries used, show all original rules.

4365

4. Check minimum number of events

None

4365

5. Include endpoints

None

4365

6. Filter based on genotype QC (FinnGen only)

4365

Control definitions (FinnGen only)

Control exclude
R18_SYMPTOMS_SIGNS_INVOLVI_CIRCULATO_RESPI_SYSTEMS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
R0
Name in latin
Murmura cardiaca et alii soni cardiaci

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 4365 2949 1416
Unadjusted period prevalence (%) 0.88 1.01 0.62
Median age at first event (years) 43.66 42.37 46.35

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
3870
Matched controls
38255
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R01.0
ICD-10 Finland
Benign and innocent cardiac murmurs
2252.6
323.0
2737
39
R01.1
ICD-10 Finland
Cardiac murmur, unspecified
99.0
323.0
1266
187
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.4
323.0
1147
2750
R07.4
ICD-10 Finland
Chest pain, unspecified
5.5
196.3
647
1356
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
5.5
155.8
506
1026
R06.0
ICD-10 Finland
Dyspnoea
4.3
152.9
636
1673
R01.2
ICD-10 Finland
Other cardiac sounds
511.8
151.0
150
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.7
135.9
670
2035
R06.5
ICD-10 Finland
Mouth breathing
10.0
84.2
174
179
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
74.5
1267
7466
R06.2
ICD-10 Finland
Wheezing
11.2
67.2
130
118
I35.0
ICD-10 Finland
Aortic (valve) stenosis
4.8
65.4
230
496
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.5
48.3
417
1765
R04.0
ICD-10 Finland
Epistaxis
6.0
48.1
137
231
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
47.0
805
4614
XF402
NOMESCO Finland
ECG with work load test
3.2
45.9
253
809
XF640
NOMESCO Finland
NA
6.6
44.3
117
179
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
41.5
666
3709
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
39.3
504
2563
R04.2
ICD-10 Finland
Haemoptysis
17.7
38.1
60
34
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
38.0
1392
9930
R05
ICD-10 Finland
Cough
2.1
37.4
498
2570
R00.2
ICD-10 Finland
Palpitations
3.5
36.2
178
521
R07.3
ICD-10 Finland
Other chest pain
3.5
36.2
178
521
R03AC02
ATC
salbutamol; inhalant
1.5
35.5
1655
12463
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.1
30.3
379
1898
C08CA01
ATC
amlodipine; oral
1.7
30.3
809
5245
R01
ICD-10 Finland
Cardiac murmurs and other cardiac sounds
51.3
30.2
36
7
UJF32
NOMESCO Finland
Coloscopy
1.7
29.6
656
4024
G47.3
ICD-10 Finland
Sleep apnoea
1.9
27.9
422
2275
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.1
27.8
160
528
C07AB07
ATC
bisoprolol; oral
1.5
27.2
1026
7236
SPAT1263
SPAT
Sampling
1.5
27.0
1484
11366
N03AX12
ATC
gabapentin; oral
1.9
26.2
386
2059
C03CA01
ATC
furosemide; systemic
1.7
26.0
569
3468
J45.1
ICD-10 Finland
Nonallergic asthma
2.5
26.0
217
898
R03DC03
ATC
montelukast; oral
1.8
25.2
476
2766
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
24.1
1094
8000
I34.1
ICD-10 Finland
Mitral (valve) prolapse
4.2
24.0
93
223
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
23.9
529
3229
SPAT1153
SPAT
Removal of sutures
1.5
23.4
893
6278
SPAT1097
SPAT
Recording of ECG
1.9
23.3
366
1995
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.1
23.2
285
1411
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
23.0
1395
10787
XFE00
NOMESCO Finland
Epicardial ultrasonography
4.4
22.7
84
193
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
22.7
356
1941
A02BC02
ATC
pantoprazole; systemic
1.4
22.4
1709
13774
N02BE01
ATC
paracetamol; systemic, rectal
1.4
21.8
2733
24013
XF404
NOMESCO Finland
Ambulatory ECG
2.3
21.3
211
952
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
3.2
20.8
110
343
R00.0
ICD-10 Finland
Tachycardia, unspecified
3.9
20.6
86
222
AA1AD
NOMESCO Finland
CT of head and brain
1.6
20.4
548
3516
XF600
NOMESCO Finland
Bloodpressure measurement
2.2
20.2
209
960
C09CA01
ATC
losartan; oral
1.6
20.1
536
3434
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.7
20.0
427
2567
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
19.9
815
5788
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.1
19.8
245
1215
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
19.7
1433
11370
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
19.6
1616
13092
1201
NOMESCO Finland
NA
198.6
19.5
20
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.6
19.4
147
577
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.5
19.4
159
650
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
19.4
1137
8672
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
19.3
409
2454
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
19.2
426
2590
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.3
19.2
100
309
SPAT1312
SPAT
General health counselling
1.4
19.2
1288
10057
R42
ICD-10 Finland
Dizziness and giddiness
1.6
19.2
516
3314
SPAT1301
SPAT
No procedures
1.4
18.9
1048
7896
C10AA05
ATC
atorvastatin; oral
1.5
18.7
793
5661
TPH07
NOMESCO Finland
Cathetrisation of artery
1.9
18.5
268
1416
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
18.2
407
2481
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
18.1
417
2560
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.9
18.1
263
1391
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
18.0
1311
10359
R03BA02
ATC
budesonide; inhalant
1.6
17.9
471
3000
R06.4
ICD-10 Finland
Hyperventilation
11.8
17.6
32
27
A11
ICPC
Chest pain NOS
2.3
17.6
160
693
J01CA04
ATC
amoxicillin; systemic
1.4
17.5
3036
27550
C08CA13
ATC
lercanidipine; oral
1.9
17.5
285
1568
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.1
17.5
206
1005
S18
ICPC
Laceration/cut
1.4
17.4
1200
9383
R00.1
ICD-10 Finland
Bradycardia, unspecified
7.1
17.3
42
59
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
17.3
2507
22046
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.5
17.2
134
536
M79.6
ICD-10 Finland
Pain in limb
1.4
17.2
968
7294
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
17.1
343
2022
R02
ICPC
Shortness of breath/dyspnoea
1.8
16.6
290
1637
M25.5
ICD-10 Finland
Pain in joint
1.4
16.1
782
5722
SPAT1325
SPAT
Vaccination
1.4
16.1
1209
9560
C01DA14
ATC
isosorbide mononitrate; oral
2.0
15.9
209
1065
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.6
15.8
115
445
R03BA05
ATC
fluticasone; inhalant
1.5
15.7
523
3529
XG410
NOMESCO Finland
Flow-volume spirometry
2.8
15.5
97
343
R03BA01
ATC
beclometasone; inhalant
1.7
15.4
323
1932
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.9
15.3
239
1300
C10AA01
ATC
simvastatin; oral
1.4
15.2
896
6788
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
3.6
15.1
67
185
A10AE04
ATC
insulin glargine; parenteral
1.9
15.0
221
1177
C09AA05
ATC
ramipril; oral
1.5
15.0
477
3185
N02AX02
ATC
tramadol; systemic, rectal
1.4
15.0
972
7482
J01DB01
ATC
cefalexin; oral
1.3
14.9
2738
24624
H02AB06
ATC
prednisolone; systemic
1.3
14.9
1200
9565
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
14.8
315
1891
L17
ICPC
Foot/toe symptom/complaint
1.4
14.7
770
5699
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
14.7
427
2787
R09.1
ICD-10 Finland
Pleurisy
5.8
14.6
41
71
DKW00
NOMESCO Finland
Cauterisation of mucosa of nose
18.2
14.6
22
12
R60.0
ICD-10 Finland
Localized oedema
1.8
14.5
243
1351
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
14.4
1114
8813
M54.6
ICD-10 Finland
Pain in thoracic spine
2.1
14.4
174
857
B01AC04
ATC
clopidogrel; oral
1.8
14.1
259
1488
SPAT1310
SPAT
Counselling related to known health issue
1.3
14.0
1093
8646
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
14.0
2476
22016
J45
ICD-10 Finland
Asthma
1.8
14.0
248
1404
XG474
NOMESCO Finland
Exhalation nntrogen oxide
3.3
14.0
69
207
N03AX16
ATC
pregabalin; oral
1.5
13.9
514
3547
C10AX09
ATC
ezetimibe; oral
1.9
13.9
200
1057
J01FF01
ATC
clindamycin; systemic
1.4
13.9
677
4941
C10AA07
ATC
rosuvastatin; oral
1.5
13.8
499
3425
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
13.8
1849
15815
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
13.8
786
5900
SPAT1262
SPAT
Handing over of treatment supplies
1.6
13.8
424
2803
AN1
HP
Coronary angiography
2.0
13.8
167
824
R03AC03
ATC
terbutaline; inhalant
1.6
13.7
353
2233
A02BC05
ATC
esomeprazole; systemic
1.4
13.7
937
7260
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
13.6
196
1037
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.6
13.6
336
2105
R51.80
ICD-10 Finland
Headache
1.5
13.5
437
2927
M54.5
ICD-10 Finland
Low back pain
1.4
13.4
850
6494
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
13.1
1128
9046
R52.9
ICD-10 Finland
Pain, unspecified
1.8
13.1
218
1214
C02AC05
ATC
moxonidine; oral
2.6
13.1
95
369
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.4
13.0
595
4281
B01AA03
ATC
warfarin; systemic
1.6
13.0
345
2201
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
13.0
512
3577
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
12.9
879
6793
A46
ICD-10 Finland
Erysipelas
1.7
12.7
285
1738
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.6
12.6
382
2514
N06AX11
ATC
mirtazapine; oral
1.4
12.6
799
6098
J01FA09
ATC
clarithromycin; systemic
1.3
12.5
920
7191
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.6
12.4
89
342
R01AD09
ATC
mometasone; nasal
1.3
12.3
1293
10645
WX892
NOMESCO Finland
Monitored bed care
1.9
12.3
177
937
R96
ICPC
Asthma
1.8
12.3
211
1187
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
12.3
502
3534
G44.2
ICD-10 Finland
Tension-type headache
1.6
12.2
342
2210
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
2.4
12.0
97
398
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.6
11.9
323
2071
R07.2
ICD-10 Finland
Precordial pain
5.9
11.8
32
54
R07.0
ICD-10 Finland
Pain in throat
1.9
11.7
164
860
R50.9
ICD-10 Finland
Fever, unspecified
1.5
11.6
416
2851
R03BA08
ATC
ciclesonide; inhalant
1.9
11.5
166
879
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
11.4
626
4656
WX872
NOMESCO Finland
Intensive care
2.4
11.4
99
422
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
11.4
1665
14268
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
2.5
11.3
90
367
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.8
11.3
183
1010
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.5
11.3
438
3043
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.0
11.3
151
779
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
11.3
1716
14769
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
2.3
11.3
101
437
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.9
11.2
176
958
A02BC01
ATC
omeprazole; systemic
1.4
11.2
633
4727
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
5.5
11.2
32
58
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.6
11.1
324
2115
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
11.1
197
1119
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
2.4
11.0
91
379
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.6
11.0
259
1601
R06AE07
ATC
cetirizine; oral
1.3
11.0
1349
11296
K02.1
ICD-10 Finland
Caries of dentine
1.3
10.9
1942
17013
H02AB04
ATC
methylprednisolone; systemic
1.5
10.8
325
2137
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.5
10.7
331
2190
A98
ICPC
Health maint/preventive medicine
1.6
10.7
3674
35213
R53
ICD-10 Finland
Malaise and fatigue
1.4
10.7
511
3702
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
10.7
377
2569
M48.0
ICD-10 Finland
Spinal stenosis
1.7
10.7
221
1316
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.4
10.6
50
147
C07AB02
ATC
metoprolol; systemic
1.5
10.6
389
2676
M70.6
ICD-10 Finland
Trochanteric bursitis
1.6
10.6
256
1592
Q21.10
ICD-10 Finland
Persistent ostium secundum
3.7
10.6
45
122
FN1AD
NOMESCO Finland
CT of coronary arteries
6.6
10.5
26
39
WX110
NOMESCO Finland
Local anesthesy
1.3
10.5
2349
21096
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.0
10.4
127
632
205
Kela drug reimbursment
Chronic hypertension
1.4
10.4
542
3991
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.4
10.4
500
3626
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.6
10.4
75
293
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
10.4
225
1362
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
10.3
236
1448
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
10.3
1787
15561
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.4
10.3
456
3258
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.6
10.3
296
1926
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
3.3
10.2
50
152
K30
ICD-10 Finland
Functional dyspepsia
1.7
10.2
228
1388
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
10.2
1505
12855
I49.3
ICD-10 Finland
Ventricular premature depolarization
2.0
10.2
132
674
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
10.2
298
1946
C09CA07
ATC
telmisartan; oral
1.9
10.2
144
760
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.7
10.1
214
1285
L03
ICPC
Low back symptom/complaint
1.4
10.1
658
5028
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
1.8
10.0
177
1006
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.6
10.0
269
1719
R01AD12
ATC
fluticasone furoate; nasal
1.3
10.0
879
7020
WX408
NOMESCO Finland
General anesthesy, balanced
1.3
9.9
735
5725
SPAT1210
SPAT
Application of cast or individual aid
2.0
9.9
125
629
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.9
9.9
146
783
A02BC03
ATC
lansoprazole; oral
1.4
9.9
601
4538
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.4
9.9
518
3816
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.6
9.9
275
1776
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
1.8
9.8
153
834
R03AK07
ATC
formoterol and budesonide; inhalant
1.4
9.8
419
2971
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
9.8
943
7621
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.4
9.8
463
3346
SPAT1254
SPAT
Administration of medicine
1.4
9.8
519
3830
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.8
9.7
169
956
UJD02
NOMESCO Finland
Gastroscopy
2.1
9.7
101
471
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
2.9
9.6
57
198
A29
ICPC
General symptom/complaint other
1.5
9.6
284
1863
R03AK08
ATC
formoterol and beclometasone; inhalant
2.5
9.6
72
287
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
9.5
98
457
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.7
9.4
187
1102
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
2.0
9.4
117
589
SBA00
NOMESCO Finland
Microbiological examinations
2.4
9.4
75
310
J01DA01
ATC
[U] cefalexin; systemic
1.2
9.2
1807
15883
I49.1
ICD-10 Finland
Atrial premature depolarization
2.5
9.2
69
274
FN1CB
NOMESCO Finland
Coronary flow reserve measurement with pressure wire
4.1
9.1
34
83
SAA03
NOMESCO Finland
Extended examination of mouth
1.2
9.1
1428
12239
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
9.0
985
8081
SPAT1260
SPAT
Consultation of another employee
1.4
9.0
498
3699
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.7
9.0
183
1087
B01AB05
ATC
enoxaparin; parenteral
1.3
9.0
678
5288
C08CA05
ATC
nifedipine; systemic
1.9
8.9
124
651
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
1.8
8.9
163
937
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.4
8.9
378
2675
WX720
NOMESCO Finland
Own respiration
2.2
8.9
88
404
GD1AD
NOMESCO Finland
Thorax CT examination
2.3
8.8
80
352
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.7
8.8
164
948
L08
ICPC
Shoulder symptom/complaint
1.4
8.7
439
3205
A07AA02
ATC
nystatin; oral
1.9
8.7
132
714
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
1.8
8.7
136
746
M03BX02
ATC
tizanidine; oral
1.2
8.7
1577
13715
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
8.6
524
3949
SPAT1101
SPAT
Orthostatic test
2.2
8.6
88
409
T90
ICPC
Diabetes non-insulin dependent
1.4
8.6
438
3208
I34.01
ICD-10 Finland
Mitral (valve) regurgitation NOS or of specified cause, except rheumatic
6.5
8.6
21
32
C09AA02
ATC
enalapril; systemic
1.4
8.6
390
2799
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
1.6
8.6
199
1230
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
2.8
8.6
54
194
FKC50
NOMESCO Finland
Repair of mitral valve for insufficiency using prosthetic chord
7.5
8.6
19
25
UDC00
NOMESCO Finland
Ear microscopy
1.6
8.5
205
1278
C09CA06
ATC
candesartan; oral
1.4
8.5
458
3383
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
2.8
8.5
52
186
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
2.7
8.5
55
203
J01FA10
ATC
azithromycin; systemic
1.2
8.4
2029
18148
D64.9
ICD-10 Finland
Anaemia, unspecified
1.6
8.4
194
1195
ZXD05
NOMESCO Finland
Urgent procedure
1.3
8.4
818
6612
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.3
8.3
562
4309
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.7
8.3
158
921
I20.09
ICD-10 Finland
Unstable angina
2.5
8.3
62
249
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
1.8
8.3
145
823
SPAT1324
SPAT
Screening procedure
1.4
8.3
470
3507
A03
ICPC
Fever
1.3
8.3
600
4651
J01MA02
ATC
ciprofloxacin; systemic
1.3
8.3
890
7278
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
2.2
8.2
78
350
J01AA02
ATC
doxycycline; systemic
1.2
8.2
2096
18835
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.0
8.2
95
465
E66.00
ICD-10 Finland
Metabolic syndrome
2.0
8.2
99
493
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
2.0
8.2
99
493
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.4
8.2
472
3530
A10AE05
ATC
insulin detemir; parenteral
1.8
8.2
142
805
WZC30
NOMESCO Finland
Teaching
1.5
8.1
301
2075
EP1AE
NOMESCO Finland
Neck ultrasound examination
1.8
8.1
134
750
WZA90
NOMESCO Finland
Other doctors statement
1.3
8.0
771
6213
J20
ICD-10 Finland
Acute bronchitis
1.6
8.0
220
1418
FM1DE
SPAT
NA
9.9
8.0
15
15
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
4.8
8.0
25
52
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.0
7.9
97
485
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
2.5
7.9
60
243
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
7.9
604
4713
R55
ICD-10 Finland
Syncope and collapse
1.5
7.9
228
1488
C03DA01
ATC
spironolactone; oral
1.6
7.9
181
1115
E66.01
ICD-10 Finland
Obesity due to excess calories
1.6
7.9
187
1159
H04.10
ICD-10 Finland
Dry eye syndrome
1.6
7.9
214
1378
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.6
7.8
188
1173
R99
ICPC
Respiratory disease other
3.0
7.8
42
139
FM2CE
NOMESCO Finland
NA
2.4
7.8
64
269
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.5
7.8
246
1639
N06AX21
ATC
duloxetine; oral
1.6
7.7
218
1414
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.4
7.7
354
2542
K02
ICPC
Pressure/tightness of heart
2.9
7.7
44
149
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
1.7
7.7
143
828
90492
NOMESCO Finland
NA
14.9
7.7
12
8
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.3
7.6
773
6266
SPAT1081
SPAT
Cardiorespiratory global assessment
1.9
7.6
115
622
SPAT1104
SPAT
Monitoring of emergency patient
1.7
7.6
154
916
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.6
7.6
201
1286
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
1.9
7.5
98
503
R06AE09
ATC
levocetirizine; oral
1.4
7.5
416
3087
KMAK
NOMESCO Finland
NA
1.2
7.5
1465
12773
PD3YT
NOMESCO Finland
Pelvic artery PTA with stent
4.9
7.5
23
47
I47.1
ICD-10 Finland
Supraventricular tachycardia
2.0
7.5
87
428
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.6
7.4
206
1332
M03BC01
ATC
orphenadrine (citrate); systemic
1.3
7.4
526
4060
Q23.11
ICD-10 Finland
Bicuspid aortic valve
3.7
7.4
30
80
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.5
7.4
254
1723
103
Kela drug reimbursment
Diabetes, insulin-treated
1.3
7.4
541
4195
SPAT1058
SPAT
PEF monitoring instruction
1.6
7.3
183
1150
A10AA02
ATC
NA
2.2
7.3
74
342
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.5
7.3
282
1960
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.2
7.3
1102
9349
SPAT1229
SPAT
Assessment of need for aid
1.7
7.3
155
936
R06.8
ICD-10 Finland
Other and unspecified abnormalities of breathing
5.2
7.3
21
40
K80
ICPC
Cardiac arrhythmia NOS
1.7
7.3
138
807
7862A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Cough
+∞
7.3
7
*
A10AA01
ATC
NA
2.3
7.2
63
272
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.3
7.2
464
3528
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
1.7
7.2
144
856
H03AA01
ATC
levothyroxine sodium; systemic
1.3
7.1
570
4472
M79.1
ICD-10 Finland
Myalgia
1.4
7.1
307
2181
C07AA05
ATC
propranolol; systemic
1.3
7.1
489
3763
M53.0
ICD-10 Finland
Cervicocranial syndrome
1.6
7.0
183
1164
XW000
NOMESCO Finland
Bone marrow biopsy
1.9
7.0
92
474
WX704
NOMESCO Finland
Intubation
1.6
7.0
170
1064
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.7
7.0
130
757
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
1.5
7.0
204
1338
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
5.5
7.0
19
34
M19.0
ICD-10 Finland
Primary arthrosis of other joints
1.6
7.0
179
1135
ZXE20
NOMESCO Finland
More than three and less than five hours
1.4
7.0
321
2307
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.3
7.0
447
3397
SPAT1100
SPAT
Long-term monitoring of blood pressure
1.7
6.9
131
765
K29
ICPC
Cardiovascular sympt/complt other
2.1
6.9
76
367
Z01.2
ICD-10 Finland
Dental examination
1.2
6.9
1430
12517
D82
ICPC
Teeth/gum disease
1.2
6.8
1139
9752
A02BC04
ATC
rabeprazole; oral
1.6
6.8
162
1008
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.6
6.8
159
987
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
2.1
6.8
68
316
JN3AD
NOMESCO Finland
Abdominal CT examination
1.6
6.8
148
901
H01
ICPC
Ear pain/earache
1.4
6.7
385
2873
R56.8
ICD-10 Finland
Other and unspecified convulsions
1.6
6.7
161
1005
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
2.1
6.7
70
330
XF602
NOMESCO Finland
Bloodpressure monitoring
3.1
6.7
34
109
M01AC06
ATC
meloxicam; systemic, rectal
1.2
6.7
834
6919
P01AB01
ATC
metronidazole; oral, rectal
1.2
6.7
977
8245
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.6
6.7
146
891
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.3
6.7
695
5643
Z94.0
ICD-10 Finland
Kidney transplant status
3.0
6.7
36
121
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.5
6.7
203
1342
SPAT1240
SPAT
Therapeutic discussion
1.4
6.7
368
2731
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.4
6.6
326
2373
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
7.1
6.6
15
21
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.3
6.6
56
239
X59
ICD-10 Finland
Exposure to unspecified factor
1.3
6.6
479
3707
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
2.2
6.6
65
301
WX725
NOMESCO Finland
Noninvasive ventilation
1.8
6.6
105
583
UDQ12
NOMESCO Finland
Flexible laryngoscopy
1.9
6.6
91
481
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
1.9
6.6
93
496
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.5
6.6
205
1365
SPAT1202
SPAT
Intra-articular injection
2.1
6.5
67
316
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.4
6.5
251
1746
L28
ICPC
Limited function/disability (L)
1.4
6.5
323
2353
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.3
6.5
396
2986
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
2.0
6.5
76
378
R05FA02
ATC
opium derivatives and expectorants; systemic
1.2
6.5
1040
8859
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
4.0
6.5
24
60
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
1.8
6.5
100
550
A01
ICPC
Pain general/multiple sites
1.6
6.5
177
1144
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.5
6.5
186
1215
SPAT1053
SPAT
Memory test
1.4
6.4
262
1840
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.4
6.4
375
2810
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
3.0
6.4
34
113
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
2.8
6.4
38
135
SGB10
NOMESCO Finland
Fiiling of rooth of tooth with one root channel
1.4
6.4
263
1855
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.4
6.4
256
1796
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
2.5
6.4
46
183
SGA01
NOMESCO Finland
Tooth opening as first aid
1.3
6.4
391
2951
J31.0
ICD-10 Finland
Chronic rhinitis
1.6
6.4
165
1051
C09DA01
ATC
losartan and diuretics; oral
1.5
6.4
197
1309
K85
ICPC
Elevated blood pressure
1.4
6.4
294
2117
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
1.5
6.4
182
1190
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
1.7
6.3
115
669
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
3.6
6.3
26
72
R07.1
ICD-10 Finland
Chest pain on breathing
3.7
6.3
25
67
SPAT1285
SPAT
Provision of consultation response
1.6
6.3
135
821
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
2.9
6.3
36
124
E0000UV
ATC
NA
1.2
6.2
1219
10583
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
1.7
6.2
121
713
78330
ICD-8 Finland
Symptoms referable to respiratory system, Cough
+∞
6.2
6
*
J46
ICD-10 Finland
Status asthmaticus
2.3
6.2
52
225
J01FA15
ATC
telithromycin; oral
1.5
6.2
202
1361
L01
ICPC
Neck symptom/complaint
1.4
6.2
353
2638
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
2.3
6.2
53
229
S97
ICPC
Chronic ulcer skin
1.8
6.1
95
522
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.4
6.1
261
1852
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
1.9
6.1
83
434
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.7
6.1
122
728
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.5
6.1
179
1176
D07AC01
ATC
betamethasone; topical
1.2
6.1
829
6934
A04
ICPC
Weakness/tiredness general
1.3
6.1
386
2929
I42.1
ICD-10 Finland
Obstructive hypertrophic cardiomyopathy
5.7
6.1
16
28
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.6
6.1
143
893
L13
ICPC
Hip symptom/complaint
1.4
6.1
332
2464
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
6.1
665
5429
XG466
NOMESCO Finland
Sleep oxymetry
2.4
6.0
47
195
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
1.4
6.0
265
1890
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
2.8
6.0
36
129
SPAT1216
SPAT
Assessment of functional ability
1.4
6.0
321
2369
K92.1
ICD-10 Finland
Melaena
1.8
6.0
96
535
UJF30
NOMESCO Finland
Ileoscopy through colon
1.5
6.0
200
1351
R06AX27
ATC
desloratadine; oral
1.2
6.0
829
6945
ZXD10
NOMESCO Finland
Scheduled procedure
1.2
6.0
1024
8769

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: R18_CARDIAC_MURMU_OTHER_CARDIAC_SOUNDS – Cardiac murmurs and other cardiac sounds

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).