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This is a non-core endpoint: only basic statistics are computed.

Malignant neoplasm of other and ill-defined sites

C3_OTHER_OR_ILLDEFINED_SITES

benign neoplasm: A neoplasm which is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign neoplasms remain confined to the original site of growth and do not metastasize to other anatomic sites.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C76
  • Cause of death: ICD-9 195
  • Cause of death: ICD-8 195
  • Cancer registry: Topography ICD-O-3 C76
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

116

4. Check minimum number of events

None

116

5. Include endpoints

None

116

6. Filter based on genotype QC (FinnGen only)

114

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 114 37 77
Unadjusted period prevalence (%) 0.03 0.01 0.04
Median age at first event (years) 74.08 78.41 72.00

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
116
Matched controls
1160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C76.2
ICD-10 Finland
Malignant neoplasm of other and ill-defined sites: Abdomen
+∞
55.8
49
*
130
Kela drug reimbursment
Malignant tumour
+∞
35.2
32
*
A03FA01
ATC
metoclopramide; systemic, rectal
8.1
22.0
36
61
8000/3-C76.2
ICD-O-3
Neoplasm, malignant of abdomen, NOS
+∞
19.3
18
*
H02AB02
ATC
dexamethasone; systemic
42.1
14.9
18
5
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
13.8
13
*
Z51.5
ICD-10 Finland
Palliative care
12.8
13.5
24
23
8140/3-C76.2
ICD-O-3
Adenocarcinoma, NOS, of abdomen, NOS
+∞
11.6
11
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
10.6
10
*
8000/3-C80.9
ICD-O-3
Neoplasm, malignant of unknown primary site
+∞
10.6
10
*
C76.0
ICD-10 Finland
Malignant neoplasm of other and ill-defined sites: Head, face and neck
+∞
9.5
9
*
C76.1
ICD-10 Finland
Malignant neoplasm of other and ill-defined sites: Thorax
+∞
9.5
9
*
C76.3
ICD-10 Finland
Malignant neoplasm of other and ill-defined sites: Pelvis
+∞
8.4
8
*
C80
ICD-10 Finland
Malignant neoplasm, without specification of site
+∞
8.4
8
*
L01BC06
ATC
capecitabine; oral
+∞
8.4
8
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
8.4
8
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
11.2
7.8
14
14
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
7.4
7
*
8140/3-C80.9
ICD-O-3
Adenocarcinoma, NOS, of unknown primary site
+∞
7.4
7
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
7.4
7
*
R18
ICD-10 Finland
Ascites
32.2
7.3
9
*
N02AA05
ATC
oxycodone; systemic
3.3
7.0
32
120
D48.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other specified sites
+∞
6.3
6
*
C26.9
ICD-10 Finland
Malignant neoplasm: Ill-defined sites within the digestive system
+∞
6.3
6
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
6.3
6
*
C80.90
ICD-10 Finland
Malignant tumor without specified localization without histology
+∞
6.3
6
*
JN4BD
NOMESCO Finland
Extensive body CT
6.0
6.1
16
30
H25.1
ICD-10 Finland
Senile nuclear cataract
0.3
6.1
14
407

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
11
15.44
9.48
1.6
1.1
—
—
—
0
0
6
0
+∞
6.30
1.0
0.0
25.94
—
ug/l
—
6
0
24
100
2.77
4.23
1.7
1.7
—
—
—
0
0
13
31
4.59
4.16
1.2
1.1
—
—
—
0
0
30
152
2.31
3.51
2.5
1.5
—
—
—
0
0
30
477
0.50
2.72
4.5
4.3
—
—
—
0
0
36
534
0.53
2.57
32.6
19.1
14.57
15.15
%
1.14
36
514
34
203
1.95
2.56
3.3
2.0
—
—
—
0
0
35
523
0.53
2.55
36.6
21.4
327.89
330.95
g/l
1.38
35
514
44
606
0.56
2.35
6.6
6.8
43.33
42.66
mmol/mol
0.15
38
541
11
40
2.93
2.35
1.1
1.3
—
—
—
0
0
21
109
2.13
2.28
1.6
1.8
0.77
0.83
mmol/l
1.44
21
96
52
676
0.58
2.15
21.7
15.4
—
—
—
0
0
53
682
0.59
2.06
32.3
18.6
94.02
88.47
umol/l
0.38
53
682
5
11
4.70
1.96
1.0
1.1
—
—
—
0
0
49
636
0.60
1.90
5.0
5.0
6.19
6.23
mmol/l
0.08
42
540
5
12
4.30
1.84
1.2
1.5
297.60
101.18
u/ml
—
5
12
36
241
1.72
1.83
4.3
4.2
—
—
—
0
0
26
158
1.83
1.82
5.1
3.1
82.69
78.27
%
0.41
26
152
47
606
0.62
1.68
4.1
4.7
4.38
4.27
mmol/l
0.34
41
531
14
70
2.14
1.67
1.4
1.2
—
—
—
0
0
50
633
0.63
1.63
4.4
5.2
2.51
2.44
mmol/l
0.25
42
547
9
176
0.47
1.56
1.9
3.7
—
—
—
0
0
15
80
2.00
1.53
2.3
1.8
—
—
—
0
0
8
164
0.45
1.50
4.9
4.9
—
1.02
—
0
29
31
214
1.61
1.38
2.7
2.9
7.35
7.40
ph
—
5
36
12
62
2.04
1.33
6.7
2.9
—
—
—
0
0
6
24
2.58
1.32
1.2
1.2
—
—
—
0
0
48
597
0.67
1.32
4.2
4.7
1.42
1.40
mmol/l
0.09
41
515
9
44
2.13
1.30
1.1
1.6
—
—
—
0
0
46
575
0.67
1.28
3.9
4.3
1.22
1.27
mmol/l
0.24
38
488
8
38
2.19
1.21
7.9
7.0
23.31
24.58
mmol/l
—
8
38
5
20
2.56
1.16
2.4
4.0
—
—
—
0
0
20
288
0.63
1.06
5.5
3.9
2.30
2.40
ug/l
0.05
20
249
44
347
1.43
1.03
8.6
3.5
17.67
12.89
umol/l
0.71
44
321
24
168
1.54
1.00
2.2
2.4
364.35
9090.11
umol/l
1.32
17
138
0
30
0.00
0.99
0.0
1.7
—
—
—
0
0
45
359
1.41
0.98
7.4
4.6
1.21
1.21
mmol/l
0.22
40
288
50
591
0.73
0.89
5.0
4.5
2.08
2.11
mu/l
0.05
45
496
43
349
1.37
0.83
8.6
5.3
4.82
4.78
e9/l
0.03
33
298
6
32
1.92
0.83
1.0
1.2
—
—
—
0
0
15
99
1.59
0.80
4.0
3.5
1.17
1.02
mmol/l
0.72
15
84
26
331
0.72
0.71
7.0
5.4
0.00
0.00
estimate
—
6
52
7
44
1.63
0.66
8.1
3.6
—
—
—
0
0
14
196
0.68
0.64
4.2
4.5
0.00
0.00
estimate
—
6
53
0
20
0.00
0.61
0.0
1.8
—
—
—
0
0
6
35
1.75
0.58
1.3
1.5
—
—
—
0
0
27
332
0.76
0.58
4.3
4.2
0.00
0.00
estimate
—
6
52
6
36
1.70
0.57
3.0
2.6
1.42
1.06
%
—
6
36
6
37
1.65
0.56
1.2
1.4
—
—
—
0
0
6
37
1.65
0.56
11.7
8.2
94.87
93.87
%
—
6
37
22
171
1.35
0.55
2.3
2.6
566.56
535.44
mosm/kgh2o
0.30
16
142
27
329
0.77
0.54
4.7
4.2
0.00
0.00
estimate
—
7
60
6
40
1.53
0.52
11.7
7.7
1.07
1.37
%
—
6
40
6
40
1.53
0.52
11.7
7.7
0.65
0.73
%
—
6
40
7
47
1.52
0.48
1.6
1.6
204.71
189.69
ug/g
—
7
35
7
50
1.43
0.46
10.4
6.6
—
—
—
0
0
5
33
1.54
0.42
7.4
4.9
—
—
—
0
0
23
188
1.28
0.42
3.9
2.8
—
—
—
0
0
5
34
1.49
0.41
1.0
1.0
—
—
—
0
0
5
36
1.41
0.38
3.2
2.6
0.68
0.67
%
—
5
36
33
287
1.21
0.35
5.3
4.9
—
—
—
0
0
27
230
1.23
0.35
3.7
2.9
46.80
367.15
e6/l
0.61
20
182
23
270
0.82
0.33
12.6
8.8
0.00
0.00
e9/l
-0.00
14
211
12
153
0.76
0.33
2.5
4.1
—
—
—
0
0
44
396
1.18
0.32
19.0
19.3
1.42
1.41
inr
0.01
11
127
34
299
1.19
0.32
5.2
4.5
2.20
2.75
%
0.96
29
266
43
475
0.85
0.32
4.0
3.5
15.06
15.22
pmol/l
0.15
38
406
24
204
1.22
0.32
3.7
2.7
0.59
0.58
e6/l
0.02
17
158
34
301
1.18
0.30
5.7
4.8
9.90
9.07
%
0.69
29
267
30
263
1.19
0.29
3.2
3.6
—
—
—
0
0
17
140
1.25
0.29
7.7
4.9
—
—
—
0
0
8
62
1.31
0.29
4.5
3.8
—
—
—
0
0
35
314
1.16
0.26
6.5
3.1
30.73
34.51
g/l
2.22
35
282
33
295
1.17
0.26
5.0
4.5
0.48
0.60
%
0.62
28
260
34
305
1.16
0.26
5.3
4.8
23.12
24.03
%
0.18
29
274
26
228
1.18
0.25
1.9
2.1
3.18
3.01
mg/l
0.15
21
185
0
11
0.00
0.21
0.0
2.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
33
300
1.14
0.21
5.3
4.5
61.41
60.69
%
0.13
28
269
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
16
185
0.84
0.20
5.2
3.9
—
—
—
0
0
11
91
1.23
0.18
9.9
4.9
102.73
104.49
mmol/l
0.47
11
91
32
344
0.90
0.14
2.2
2.2
107.23
87.19
pmol/l
0.79
20
179
19
208
0.90
0.11
2.3
1.9
1441.22
1215.67
nmol/l
0.28
13
148
10
86
1.18
0.11
9.1
5.1
11.70
10.54
kpa
—
10
81
10
86
1.18
0.11
9.1
5.1
0.37
1.61
mmol/l
—
10
64
10
86
1.18
0.11
9.1
5.1
5.24
5.01
kpa
—
10
81
5
45
1.12
0.10
2.4
2.4
—
—
—
0
0
27
253
1.09
0.09
4.3
3.5
42.86
82.73
e6/l
0.76
20
191
5
48
1.04
0.09
2.6
1.4
—
—
—
0
0
7
68
1.03
0.08
1.1
1.4
—
—
—
0
0
33
316
1.06
0.06
5.3
4.2
0.64
0.63
e9/l
0.07
22
269
13
140
0.92
0.04
1.3
1.2
—
—
—
0
0
33
319
1.05
0.04
5.3
4.2
0.04
0.04
e9/l
0.34
23
271
34
329
1.05
0.04
5.5
4.5
0.15
0.19
e9/l
1.23
26
280
33
326
1.02
0.00
5.4
4.3
1.44
1.69
e9/l
0.91
24
280
48
476
1.01
0.00
4.7
4.3
—
—
—
0
0
24
241
0.99
0.00
4.0
3.3
19.38
6.65
mg/mmol
0.47
16
160
6
62
0.97
0.00
1.3
1.4
62.62
67.50
g/l
—
6
54
5
55
0.91
0.00
4.6
2.7
84.00
87.77
ng/l
—
5
48
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
338.71
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
47.42
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
765.20
—
0
5
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
22
220
1.00
-0.00
3.7
2.8
132.11
316.62
mg/l
0.29
16
153
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
60
1.00
-0.00
3.7
3.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
58
0.86
-0.00
1.4
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
57
0.87
-0.00
8.2
3.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
23
230
1.00
-0.00
4.9
4.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_OTHER_OR_ILLDEFINED_SITES – Malignant neoplasm of other and ill-defined sites

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).