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Malignant neoplasm of other and ill-defined sites

C3_OTHER_OR_ILLDEFINED_SITES

benign neoplasm: A neoplasm which is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign neoplasms remain confined to the original site of growth and do not metastasize to other anatomic sites.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C76
  • Cause of death: ICD-9 195
  • Cause of death: ICD-8 195
  • Cancer registry: Topography ICD-O-3 C76
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

99

4. Check minimum number of events

None

99

5. Include endpoints

None

99

6. Filter based on genotype QC (FinnGen only)

99

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 99 27 72
Unadjusted period prevalence (%) 0.03 0.01 0.03
Median age at first event (years) 72.66 76.80 71.11

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
88
Matched controls
880
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C76.2
ICD-10 Finland
Malignant neoplasm of other and ill-defined sites: Abdomen
+∞
37.1
33
*
8000/3-C76.2
ICD-O-3
Neoplasm, malignant of abdomen, NOS
+∞
12.8
12
*
8140/3-C76.2
ICD-O-3
Adenocarcinoma, NOS, of abdomen, NOS
+∞
11.7
11
*
8000/3-C80.9
ICD-O-3
Neoplasm, malignant of unknown primary site
49.6
7.9
9
*
130
Kela drug reimbursment
Malignant tumour
5.9
7.5
21
44
C80.90
ICD-10 Finland
Malignant tumor without specified localization without histology
+∞
7.4
7
*
C80
ICD-10 Finland
Malignant neoplasm, without specification of site
43.5
6.9
8
*
A98
ICPC
Health maint/preventive medicine
0.3
6.6
24
495
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
15.9
6.6
10
7
8000/3-C76.1
ICD-O-3
Neoplasm, malignant of thorax, NOS
+∞
6.3
6
*
C76.1
ICD-10 Finland
Malignant neoplasm of other and ill-defined sites: Thorax
+∞
6.3
6
*
C26.9
ICD-10 Finland
Malignant neoplasm: Ill-defined sites within the digestive system
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
5
0
+∞
5.25
1.0
0.0
26.1
—
ug/l
—
5
0
35
555
0.43
3.90
28.0
23.6
84.1
89.6
umol/l
0.56
35
555
19
386
0.37
3.80
3.8
4.5
—
—
—
0
0
34
541
0.43
3.76
17.2
18.5
—
—
—
0
0
22
417
0.39
3.74
26.5
24.8
14.5
14.2
%
0.63
22
402
29
457
0.48
2.73
21.2
22.2
33.7
37.5
%
0.67
19
286
26
408
0.51
2.28
31.5
27.7
327.3
330.4
g/l
1.28
26
401
14
272
0.43
2.23
4.1
5.2
2.0
3.1
ug/l
0.44
14
231
5
130
0.35
1.79
2.0
3.2
—
—
—
0
0
5
15
3.45
1.54
1.0
1.3
—
—
—
0
0
0
38
0.00
1.37
0.0
2.6
—
—
—
0
0
7
136
0.48
1.21
3.0
4.7
—
—
—
0
0
18
269
0.60
1.16
1.9
2.3
93.3
87.8
pmol/l
0.15
12
142
8
146
0.51
1.15
6.8
4.4
—
—
—
0
0
6
121
0.46
1.15
5.2
6.0
—
1.0
—
0
13
14
221
0.57
1.10
4.0
4.6
—
—
—
0
0
19
276
0.61
1.08
6.5
4.4
31.3
34.3
g/l
1.00
19
248
30
393
0.66
1.07
3.9
5.2
—
—
—
0
0
9
47
2.00
1.05
1.3
1.3
—
—
—
0
0
20
284
0.63
1.03
4.9
5.8
1.5
1.9
e9/l
0.79
15
248
20
284
0.63
1.03
5.0
5.9
0.2
0.2
e9/l
0.15
15
248
0
32
0.00
0.97
0.0
2.2
—
8.4
—
0
27
20
275
0.66
0.87
4.7
5.8
0.0
0.0
e9/l
0.10
15
241
5
97
0.49
0.83
5.6
6.1
0.5
1.2
mmol/l
—
5
71
5
98
0.48
0.83
5.6
6.0
5.4
4.9
kpa
—
5
90
5
98
0.48
0.83
5.6
6.0
12.4
10.6
kpa
—
5
91
5
100
0.47
0.82
2.6
5.3
—
—
—
0
0
20
272
0.67
0.82
4.8
5.8
0.6
0.6
e9/l
0.09
15
237
0
26
0.00
0.79
0.0
1.6
—
—
—
0
0
11
68
1.69
0.75
1.8
2.1
—
—
—
0
0
11
164
0.63
0.69
4.5
3.6
—
—
—
0
0
17
230
0.69
0.67
2.9
3.9
—
—
—
0
0
0
23
0.00
0.59
0.0
4.1
—
—
—
0
0
5
85
0.57
0.47
5.4
6.5
97.0
94.1
%
—
5
80
13
95
1.42
0.46
1.6
3.2
0.8
0.8
mmol/l
0.89
13
83
23
188
1.29
0.42
3.2
2.6
—
—
—
0
0
8
59
1.39
0.42
1.3
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
2.3
—
15.2
—
0
7
8
60
1.36
0.41
2.1
3.9
—
—
—
0
0
0
16
0.00
0.41
0.0
2.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
14
176
0.76
0.36
5.0
4.9
—
—
—
0
0
6
44
1.39
0.35
1.0
1.5
—
—
—
0
0
16
195
0.79
0.32
3.4
5.9
—
—
—
0
0
7
53
1.34
0.31
1.4
1.6
482.9
436.9
nmol/l
—
7
43
18
214
0.81
0.30
1.6
2.0
144.8
289.5
u/l
0.88
18
196
12
95
1.30
0.28
2.2
2.0
—
—
—
0
0
14
169
0.80
0.26
2.8
2.8
8.7
7.2
mmol/l
0.65
14
144
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
1.2
—
0
11
0
10
0.00
0.21
0.0
1.3
—
0.3
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
1.4
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
17
146
1.20
0.21
4.5
3.9
81.0
78.2
%
0.16
17
140
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.5
—
—
—
0
0
8
68
1.19
0.17
2.3
4.0
—
—
—
0
0
29
314
0.89
0.15
9.2
5.9
17.7
11.4
umol/l
0.79
29
295
21
232
0.88
0.15
3.9
4.4
—
—
—
0
0
6
55
1.10
0.09
1.2
1.6
—
—
—
0
0
5
61
0.81
0.08
2.2
2.6
—
7.4
—
0
7
5
62
0.80
0.08
2.2
2.5
5.5
5.0
kpa
—
5
55
7
65
1.08
0.08
1.6
5.4
10.5
11.4
mmol/l
—
7
60
7
68
1.03
0.08
1.4
1.2
—
—
—
0
0
13
143
0.90
0.08
8.9
7.2
—
—
—
0
0
10
102
0.98
0.00
1.5
4.9
1.0
1.0
mmol/l
—
10
87
20
205
0.97
0.00
2.3
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
3.6
—
—
—
0
0
0
7
0.00
0.00
0.0
3.3
—
60.9
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
3.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
3.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
91.0
—
0
8
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
9
0.00
0.00
0.0
4.7
—
58.6
—
0
9
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
10
100
1.00
0.00
1.4
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.5
—
4.4
—
0
8
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
6
67
0.89
0.00
3.8
7.0
1.4
1.2
mmol/l
—
6
60
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
5
56
0.89
0.00
5.2
9.7
—
—
—
0
0
0
9
0.00
0.00
0.0
2.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
31.6
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
246.0
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
7.0
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
28.4
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_OTHER_OR_ILLDEFINED_SITES – Malignant neoplasm of other and ill-defined sites

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).