Benign neoplasm: Urinary organ, other/unspecified

CD2_BENIGN_URINARY_NOS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D30.7&, D30.9&
  • Hospital discharge: ICD-9 223[8-9]
  • Hospital discharge: ICD-8 223[8-9]
  • Cause of death: ICD-10 D30.7&, D30.9&
  • Cause of death: ICD-9 223[8-9]
  • Cause of death: ICD-8 223[8-9]

2 out of 7 registries used, show all original rules.

101

4. Check minimum number of events

None

101

5. Include endpoints

None

101

6. Filter based on genotype QC (FinnGen only)

96

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 991 579 393
Only index persons 703 426 277
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.01 0.02 0.01
Median age at first event (years)
Whole population 58.75 57.59 60.12
Only index persons 53.30 53.31 53.29

-FinnGen-

Key figures

All Female Male
Number of individuals 96 61 35
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 49.06 44.86 56.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
101
Matched controls
1010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D30.9
ICD-10 Finland
Benign neoplasm: Urinary organ, unspecified
+∞
60.7
52
*
22388
ICD-8 Finland
Benign neoplasm of kidney and other urinary organs, Other specified sites
+∞
21.6
20
*
D30.0
ICD-10 Finland
Benign neoplasm: Kidney
67.3
10.9
12
*
D30.7
ICD-10 Finland
Benign neoplasm: Other urinary organs
+∞
10.6
10
*
UKC02
NOMESCO Finland
Cystoscopy
4.5
9.8
30
87
22399
ICD-8 Finland
Benign neoplasm of kidney and other urinary organs, Unspecified site
+∞
9.5
9
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
53
361
1.99
2.87
13.2
12.7
1.09
1.27
inr
1.09
16
106
32
189
2.01
2.54
2.7
3.0
0.23
0.48
e6/l
0.81
25
148
39
255
1.86
2.27
3.1
3.5
141.07
53.23
e6/l
0.43
29
189
31
189
1.92
2.22
2.7
2.9
—
—
—
0
0
44
308
1.76
2.00
3.6
2.6
115.16
106.13
ug/l
0.13
39
288
9
34
2.80
1.92
14.3
4.9
23.92
25.53
mmol/l
—
9
34
29
181
1.84
1.92
2.2
2.0
2.48
2.96
mg/l
0.72
24
159
33
216
1.78
1.87
2.7
3.0
25.98
329.73
e6/l
0.55
25
176
14
67
2.26
1.86
5.7
3.2
—
—
—
0
0
5
13
3.99
1.73
1.4
1.4
—
—
—
0
0
5
14
3.70
1.63
2.4
1.9
5.02
4.81
kpa
—
5
14
5
14
3.70
1.63
2.4
1.9
8.76
9.14
kpa
—
5
14
64
517
1.65
1.59
6.1
4.3
—
—
—
0
0
17
95
1.95
1.54
1.4
1.5
664.00
577.60
titre
—
5
25
11
53
2.21
1.44
1.2
1.2
—
—
—
0
0
44
331
1.58
1.42
3.7
3.7
35.63
35.28
g/l
0.18
39
310
17
98
1.88
1.42
2.8
2.6
117.26
2.88
e6/l
—
8
61
41
305
1.58
1.38
2.4
1.9
93.84
98.27
pmol/l
0.27
23
142
6
25
2.49
1.26
2.7
2.2
—
—
—
0
0
20
131
1.66
1.10
2.1
1.4
1.92
2.40
g/l
0.45
12
73
23
161
1.55
0.98
1.4
1.2
0.48
2.22
u/ml
—
6
50
8
42
1.98
0.91
1.5
1.5
—
—
—
0
0
11
65
1.78
0.86
6.0
3.0
—
—
—
0
0
0
25
0.00
0.80
0.0
3.1
—
4.01
—
0
25
21
151
1.49
0.79
2.8
1.6
1159.79
1207.52
nmol/l
0.10
14
118
15
101
1.57
0.75
1.3
1.3
—
—
—
0
0
39
319
1.36
0.74
3.8
3.7
36.40
31.55
ng/l
0.13
25
226
13
85
1.61
0.73
2.5
1.4
—
—
—
0
0
7
40
1.80
0.73
3.1
1.3
—
—
—
0
0
11
69
1.67
0.72
15.2
5.0
—
—
—
0
0
54
467
1.34
0.70
6.0
4.0
7.30
6.69
mmol/l
1.14
48
439
16
220
0.68
0.69
3.9
3.1
13.67
26.72
mg/l
—
10
142
8
51
1.62
0.62
17.6
5.0
—
—
—
0
0
18
133
1.43
0.60
3.2
2.8
0.83
0.82
mmol/l
0.04
18
127
43
367
1.30
0.59
5.6
3.8
0.00
0.00
estimate
-0.00
14
81
63
566
1.30
0.58
6.2
4.3
14.75
14.89
pmol/l
0.16
54
512
10
65
1.60
0.58
1.2
1.8
—
—
—
0
0
43
368
1.29
0.57
7.0
5.2
0.00
0.00
estimate
-0.00
14
77
6
37
1.66
0.56
1.2
1.2
—
—
—
0
0
9
64
1.45
0.53
6.2
3.9
1.21
1.23
mmol/l
—
9
56
14
101
1.45
0.53
7.1
3.5
1.05
1.00
mmol/l
0.25
14
89
9
65
1.42
0.52
1.7
1.7
—
—
—
0
0
12
84
1.49
0.52
1.2
1.4
—
—
—
0
0
43
372
1.27
0.52
13.2
6.3
1.21
1.22
mmol/l
0.20
33
321
43
372
1.27
0.52
5.5
3.8
0.00
0.00
estimate
-0.00
14
75
63
572
1.27
0.50
5.7
4.3
12.60
12.46
mm/h
0.03
58
525
48
536
0.80
0.47
4.4
3.8
—
—
—
0
0
22
177
1.31
0.45
1.7
1.6
21.38
20.74
nmol/l
0.04
16
147
11
79
1.44
0.43
1.5
1.5
—
—
—
0
0
5
33
1.54
0.42
8.6
3.4
—
—
—
0
0
0
15
0.00
0.41
0.0
2.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
4.12
—
0
17
0
17
0.00
0.41
0.0
1.9
—
107.53
—
0
17
0
17
0.00
0.41
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
2.5
—
17.47
—
0
18
5
35
1.45
0.40
1.0
1.8
—
—
—
0
0
30
257
1.24
0.38
5.0
2.9
—
—
—
0
0
25
210
1.25
0.37
7.0
3.8
0.00
0.00
estimate
-0.00
14
75
43
384
1.21
0.37
5.1
5.2
0.54
0.58
e9/l
0.45
34
337
6
41
1.49
0.37
20.0
6.3
95.73
93.26
%
—
6
41
44
394
1.21
0.36
5.0
5.8
0.19
0.19
e9/l
0.01
36
349
44
394
1.21
0.36
5.0
5.3
1.83
1.98
e9/l
0.39
36
354
43
385
1.20
0.36
5.1
5.2
0.03
0.04
e9/l
0.61
34
338
66
615
1.21
0.35
9.1
6.9
82.74
76.98
u/l
0.32
61
575
13
100
1.34
0.35
1.7
1.7
—
—
—
0
0
13
101
1.33
0.33
1.2
1.2
—
—
—
0
0
38
339
1.19
0.32
10.7
9.6
0.00
0.00
e9/l
0.50
30
278
28
244
1.20
0.30
4.3
3.4
—
—
—
0
0
73
693
1.19
0.29
6.9
5.0
1.75
1.93
mu/l
0.57
64
621
79
756
1.21
0.27
18.7
13.6
23.29
21.25
mg/l
0.22
68
617
68
714
0.85
0.26
4.3
4.1
1.42
1.25
mmol/l
1.14
62
643
25
220
1.18
0.24
5.1
3.5
—
—
—
0
0
11
88
1.28
0.23
1.1
1.3
—
—
—
0
0
71
741
0.86
0.23
4.8
4.6
1.40
1.51
mmol/l
1.46
66
677
21
239
0.85
0.22
4.9
3.6
7.25
5.25
mg/mmol
0.17
13
146
5
41
1.23
0.22
1.2
1.3
—
—
—
0
0
5
42
1.20
0.22
23.6
6.0
0.50
0.71
%
—
5
42
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
49
458
1.14
0.21
8.0
9.6
3.75
4.10
e9/l
0.53
38
405
0
12
0.00
0.21
0.0
1.2
—
50.67
—
0
12
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
40
369
1.14
0.21
5.9
5.5
—
—
—
0
0
28
254
1.14
0.18
3.4
3.1
—
—
—
0
0
72
746
0.88
0.18
4.6
4.7
4.77
4.65
mmol/l
0.48
67
687
8
68
1.19
0.17
3.1
2.3
—
—
—
0
0
18
159
1.16
0.16
6.2
3.7
—
—
—
0
0
45
424
1.11
0.16
6.4
5.6
10.34
10.61
umol/l
0.08
39
403
15
131
1.17
0.15
1.2
1.3
61.50
7.83
u/ml
—
5
56
11
93
1.21
0.15
12.1
5.6
107.00
103.87
mmol/l
1.33
11
93
82
800
1.13
0.13
20.9
16.1
82.94
74.90
umol/l
0.85
82
800
15
168
0.87
0.13
8.4
4.0
1.01
1.02
kg/l
—
5
22
10
86
1.18
0.11
13.4
5.8
5.19
5.23
kpa
—
10
81
73
711
1.10
0.11
7.2
6.0
40.47
40.65
mmol/mol
0.05
68
659
5
43
1.17
0.10
23.6
5.9
0.92
1.64
%
—
5
43
6
57
1.06
0.08
1.8
1.3
—
—
—
0
0
7
65
1.08
0.08
3.3
2.3
-1.19
2.93
mmol/l
—
7
52
7
66
1.07
0.08
1.6
1.4
—
—
—
0
0
75
764
0.93
0.07
5.3
5.2
2.86
2.71
mmol/l
0.65
68
695
12
110
1.10
0.05
2.4
1.8
—
—
—
0
0
23
219
1.07
0.05
4.6
3.9
—
—
—
0
0
77
780
0.95
0.04
20.4
13.2
—
—
—
0
0
31
301
1.04
0.03
2.2
2.1
—
—
—
0
0
74
732
1.04
0.02
5.9
4.8
6.12
5.95
mmol/l
0.57
67
674
21
204
1.04
0.00
2.4
6.8
—
—
—
0
0
23
235
0.97
0.00
4.6
3.3
7.36
7.40
ph
—
9
45
19
191
0.99
0.00
1.7
1.5
—
—
—
0
0
25
249
1.01
0.00
2.4
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
188.76
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
36.60
—
0
5
5
53
0.94
-0.00
1.4
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.75
—
0
6
0
5
0.00
-0.00
0.0
5.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
147.33
—
0
6
0
7
0.00
-0.00
0.0
1.7
—
0.83
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
15.7
—
819.67
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
1.58
—
0
5
0
6
0.00
-0.00
0.0
31.5
—
1561.00
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_URINARY_NOS and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_URINARY_NOS 2.076 [1.53, 2.81] < 0.001
Birth year 0.992 [0.98, 1.0] 0.075

During the follow-up period (1.1.1998 — 31.12.2019), 107 out of 274 females with CD2_BENIGN_URINARY_NOS died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_URINARY_NOS 1.753 [1.16, 2.64] 0.007
Birth year 0.989 [0.98, 1.0] 0.017

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 186 males with CD2_BENIGN_URINARY_NOS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_URINARY_NOS.

N-year risk Females Males
1 0.158% 0.392%
5 1.142% 2.311%
10 2.997% 5.351%
15 5.58% 10.066%
20 9.505% 17.181%

Relationships between endpoints

Index endpoint: CD2_BENIGN_URINARY_NOS – Benign neoplasm: Urinary organ, other/unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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