Lipomatosis, not elsewhere classified

E4_LIPOMATOSIS

lipomatosis: an autosomal dominant condition in which multiple lipomas are present on the body. Many discrete, encapsulated lipomas form on the trunk and extremities, with relatively few on the head and shoulders.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E88.2# Cause of death: ICD-10 — E88.2# 2 out of 7 registries used, show all original rules.	98
4. Check minimum number of events None	98
5. Include endpoints None	98
6. Filter based on genotype QC (FinnGen only)	98

Control definitions (FinnGen only)

Control exclude: E4_METABOLIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E88
Name in latin: Lipomatosis non alibi classificata

NAME	E4_LIPOMATOSIS
CONTROL_EXCLUDE	E4_METABOLIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E882
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E882
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Lipomatosis, not elsewhere classified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Lipomatosis, not elsewhere classified, drug-induced

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	515	278	233
Only index persons	487	269	218
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	53.98	54.63	53.59
Only index persons	54.26	54.83	53.56

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	98	59	39
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	56.26	57.23	54.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
85: Matched controls
850

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E88.2

ICD-10 Finland

Lipomatosis, not elsewhere classified

+∞

120.4

D17.1

ICD-10 Finland

Benign lipomatous neoplasm of skin and subcutaneous tissue of trunk

13.7

9.0

D17.2

ICD-10 Finland

Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs

24.9

8.2

M48.0

ICD-10 Finland

Spinal stenosis

6.6

8.1

N03AX12

ATC

gabapentin; oral

4.9

7.7

N03AX16

ATC

pregabalin; oral

4.0

7.3

115

D17.9

ICD-10 Finland

Benign lipomatous neoplasm, unspecified

43.6

6.9

N02AX02

ATC

tramadol; systemic, rectal

3.4

6.8

253

QBE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin of trunk

6.2

6.4

215

Kela drug reimbursment

Diabetes, non-insulin-treated

3.8

6.2

102

R5140

NOMESCO Finland

Monitoring the use of the aid

5.1

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

203

3.67

9.21

3.6

3.0

946.7

967.2

ng/l

0.02

176

(3012516) Albumin [Mass/volume] in Urine

211

3.09

6.90

3.9

2.9

90.8

335.5

mg/l

0.36

133

(3009508) Creatinine [Moles/volume] in Urine

219

2.95

6.36

3.9

2.8

7.7

mmol/l

0.00

185

(3013115) Eosinophils [#/volume] in Blood

412

2.98

6.01

8.0

5.2

0.2

e9/l

0.80

373

(3020682) Albumin/Creatinine [Ratio] in Urine

226

2.83

5.91

4.6

3.6

15.0

5.3

mg/mmol

0.38

141

(42870588) Differential panel, method unspecified - Blood

250

2.80

5.88

7.1

4.9

—

(3001604) Monocytes [#/volume] in Blood

400

2.86

5.70

7.5

5.1

0.6

0.5

e9/l

1.52

352

(3006315) Basophils [#/volume] in Blood

402

2.83

5.61

7.5

5.1

0.0

e9/l

1.09

355

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

168

2.81

5.34

1.9

1.6

1.0

0.9

mg/l

0.12

126

(3019198) Lymphocytes [#/volume] in Blood

412

2.72

5.19

7.6

5.1

1.9

1.8

e9/l

0.25

373

(3022313) Gas panel - Capillary blood

4.42

4.58

5.4

2.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

537

2.69

4.26

6.9

3.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.93

4.24

2.3

1.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

464

2.40

3.95

11.2

9.8

4.7

3.8

e9/l

2.44

413

(3032080) INR in Blood by Coagulation assay

265

2.29

3.87

11.9

6.1

1.1

1.2

inr

0.08

(40760888) Immunoglobulin light chains.free panel - Serum

7.14

3.75

1.1

5.3

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

421

2.29

3.75

8.1

5.7

9.0

11.0

umol/l

2.36

398

(3023368) Bacteria identified in Blood by Culture

181

2.35

3.67

6.3

3.9

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

599

2.64

3.66

5.4

3.8

14.3

14.8

pmol/l

1.01

543

(40758558) Short blood count panel - Blood

189

2.33

3.65

8.2

6.1

—

(3026008) Bacteria identified in Urine by Culture

215

2.25

3.54

5.1

2.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

353

2.18

3.51

10.5

5.1

1.2

mmol/l

0.16

296

(40768804) Tissue Pathology biopsy report

335

2.09

3.18

1.8

2.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

282

2.10

3.18

2.3

1.7

98.6

100.5

pmol/l

0.10

135

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

161

2.24

3.12

1.1

1.2

16.9

35.0

iu/ml

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.68

3.11

3.6

3.3

—

(3000991) Gas panel - Venous blood

3.04

2.95

17.5

5.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

797

3.52

2.94

6.0

4.3

6.3

5.9

mmol/l

1.82

741

(3021901) Oxygen saturation in Capillary blood

7.01

2.91

5.0

2.9

—

(3026782) Osmolality of Urine

130

2.24

2.78

5.3

2.4

564.1

557.7

mosm/kgh2o

0.05

105

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.37

2.73

10.3

5.6

24.6

25.3

mmol/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

775

2.97

2.71

21.9

11.3

79.9

82.3

ml/min/173m2

0.37

632

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.13

2.68

1.4

1.1

—

(3018418) pH of Serum or Plasma

220

2.01

2.63

4.1

3.3

7.4

—

(3012544) pH of Venous blood

2.79

2.56

8.3

3.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

112

2.24

2.56

2.5

1.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.90

2.56

1.4

1.5

—

(1002224) Polysomnography panel

2.90

2.56

1.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

4.62

2.52

1.3

1.1

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

619

2.14

2.47

9.9

6.7

78.6

75.8

u/l

0.43

577

(3000850) Epithelial cells [#/volume] in Urine

153

2.06

2.40

4.6

2.5

5.8

4.8

e6/l

0.38

136

(3024928) Oxygen saturation in Venous blood

6.51

2.40

12.0

4.3

—

(40768797) Stomach Pathology biopsy report

103

2.18

2.25

1.2

1.3

—

(3030467) Casts [#/volume] in Urine by Automated count

199

1.90

2.17

7.6

2.7

0.3

0.5

e6/l

0.29

146

(3044889) 12 lead EKG panel

571

1.88

2.06

4.6

3.6

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.51

2.00

3.0

2.4

—

(3000492) Spirometry study

2.35

1.99

1.9

1.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

116

2.03

1.98

6.8

2.3

2.2

0.8

e6/l

0.56

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

283

1.77

1.97

3.7

3.2

93.9

30.3

ng/l

0.42

184

(3035350) Ketones [Presence] in Urine by Test strip

385

1.75

1.96

5.6

3.3

0.0

estimate

0.00

(3044640) Blood type and Crossmatch panel - Blood

214

1.82

1.95

3.1

2.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.20

1.93

2.2

1.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

102

2.07

1.93

7.4

2.5

4.2

2.8

e6/l

0.17

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

3.34

1.92

1.9

1.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.67

1.90

1.8

1.4

—

(36304419) Bacteria [Presence] in Urine

200

1.80

1.85

6.9

2.6

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

3.06

1.76

1.4

1.5

0.3

0.2

g/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.15

1.75

1.9

1.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

137

1.89

1.75

1.8

1.6

1163.2

1272.1

nmol/l

0.23

103

(3004588) Protein electrophoresis panel - Serum or Plasma

2.54

1.74

1.2

1.4

—

(3009261) Glucose [Presence] in Urine by Test strip

394

1.68

1.73

5.7

3.3

0.0

estimate

0.00

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

221

1.74

1.73

1.7

2.1

1.3

mmol/l

1.71

179

(3011397) Hemoglobin [Presence] in Urine by Test strip

162

1.82

1.72

6.0

3.4

—

(3003396) Base excess in Arterial blood by calculation

2.12

1.70

9.7

6.1

2.3

1.6

mmol/l

—

(3021589) Normoblasts [#/volume] in Blood

367

1.67

1.70

13.1

8.9

0.0

e9/l

0.45

299

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.93

1.68

1.4

1.5

1.3

1.1

g/l

—

(3007164) IgA [Mass/volume] in Serum or Plasma

147

1.84

1.68

1.7

1.3

1.9

2.4

g/l

1.54

(3021601) Nitrite [Presence] in Urine by Test strip

388

1.66

1.65

8.2

4.3

0.0

estimate

0.00

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

165

1.78

1.62

2.7

2.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

260

1.68

1.61

7.1

2.9

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.82

1.61

1.1

1.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.45

1.54

1.4

1.0

—

(3023520) Reticulocytes [#/volume] in Blood

2.26

1.51

1.4

3.1

62.5

66.0

e9/l

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

2.18

1.51

3.9

2.5

68.6

71.3

ml/min/173m2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.98

1.45

2.3

1.6

—

(3000494) Fungus identified in Specimen by Culture

1.98

1.45

1.9

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.95

1.40

2.0

1.7

—

(3019225) pH of Specimen

2.02

1.36

7.8

3.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

735

1.84

1.36

26.0

11.4

40.0

40.5

0.18

549

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.88

1.35

2.6

1.8

29.4

29.3

0.02

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

2.59

1.32

1.5

1.8

27.2

42.9

nmol/l

—

(3002582) Erythrocytes [#/volume] in Urine

221

1.59

1.24

8.0

2.9

13.9

337.4

e6/l

0.58

171

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

152

1.67

1.23

1.1

1.2

0.7

3.0

u/ml

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

350

1.53

1.23

4.4

3.9

—

(3042936) Bacteria identified in Isolate by Culture

111

1.76

1.23

3.1

1.7

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

153

1.66

1.20

1.9

1.8

371.0

461.0

pmol/l

1.35

135

(3018095) Leukocytes [#/volume] in Urine

262

1.52

1.12

9.2

3.4

58.9

45.5

e6/l

0.13

188

(3002256) Pathology report gross observation

114

1.71

1.12

1.1

1.3

—

(3025941) Bacteria identified in Stool by Culture

2.03

1.11

1.4

1.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.34

1.04

1.4

1.5

—

(40761511) CBC panel - Blood by Automated count

851

1.97

0.96

20.0

10.9

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.22

0.93

2.7

1.6

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.22

0.93

2.7

1.6

—

(3000330) Specific gravity of Urine by Test strip

2.14

0.91

8.5

2.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

808

1.68

0.83

25.0

11.6

22.7

21.1

mg/l

0.21

621

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

314

1.40

0.83

5.3

3.4

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.78

0.0

5.1

—

1.1

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.81

0.77

18.5

6.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.14

0.75

1.0

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.91

0.75

4.0

1.5

—

(3052851) Hemolysis interference index of Serum or Plasma

2.05

0.74

2.8

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

1.97

0.71

1.6

2.9

8.6

10.2

mg/l

—

(3013512) EKG study

237

1.38

0.70

5.5

3.0

—

(4010399)

1.65

0.64

2.1

1.4

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.70

0.62

2.0

2.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

115

1.47

0.61

2.4

1.8

—

(36660697) Celiac disease serology panel - Serum

1.59

0.61

1.3

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.61

0.0

1.5

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.66

0.56

10.5

2.1

119.5

134.2

g/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

199

1.34

0.55

7.2

4.9

—

(40768443) Skin Pathology biopsy report

1.53

0.52

1.0

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

229

1.31

0.52

4.6

3.0

—

(3029937) Albumin [Presence] in Urine by Test strip

223

1.29

0.46

5.5

3.7

0.0

estimate

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.43

0.46

1.6

1.3

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.64

0.43

1.8

1.7

26.2

24.7

mmol/l

—

(40761535) Cells panel - Urine sediment

1.41

0.43

4.0

3.3

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.54

0.42

12.2

1.7

1.1

1.8

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.40

0.40

4.7

4.2

1.2

mmol/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.41

0.39

3.2

1.4

—

(4035726)

1.33

0.38

1.2

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

494

1.21

0.36

2.8

3.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

187

0.77

0.36

5.3

4.2

21.9

21.6

—

(40761536) Microorganisms panel - Urine sediment

1.41

0.36

5.7

3.7

—

(21494755) Public health laboratory ask at order entry panel

0.66

0.34

2.0

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.37

0.31

1.7

1.4

—

(3022145) Colonoscopy Study observation

1.30

0.25

1.2

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.37

0.24

23.6

5.3

93.2

92.9

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.33

0.23

23.6

5.1

0.5

0.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.30

0.23

23.6

5.1

1.4

1.8

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.20

0.22

3.0

2.5

—

(3003694) ABO and Rh group [Type] in Blood

203

1.17

0.21

1.4

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.21

0.0

1.1

—

0.9

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.5

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.5

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.4

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.3

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.0

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.4

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.2

—

3.1

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

0.9

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

23.0

—

(3019060) Gas panel - Arterial blood

1.24

0.20

1.8

3.7

—

(3022621) pH of Urine by Test strip

1.22

0.18

4.6

2.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.19

0.13

10.9

7.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.78

0.08

1.4

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.03

0.08

1.7

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.09

0.08

1.7

2.1

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.85

0.07

1.9

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

138

1.10

0.07

1.8

1.5

—

(1761868) Lipid panel - Serum or Plasma

309

1.05

0.04

3.3

2.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

127

0.94

0.02

1.3

1.4

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.4

—

13.4

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

5.3

—

0.6

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.7

—

1.7

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.0

1.6

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

6.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

1.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

1.0

—

4.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.5

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

0.9

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

12.8

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

1.4

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

136.6

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

55.9

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

26.1

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.1

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.2

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

12.7

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.5

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.3

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

0.0

1.3

—

198.0

—

(3002385) Erythrocyte distribution width [Ratio]

680

1.00

0.00

33.6

14.1

14.0

13.7

0.48

671

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.5

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

1.0

—

107.0

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

1.2

—

7.3

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_LIPOMATOSIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_LIPOMATOSIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_LIPOMATOSIS – Lipomatosis, not elsewhere classified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Lipomatosis, not elsewhere classified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints