Food allergy

FOOD_ALLERGY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L23.6
  • Cause of death: ICD-10 L23.6

2 out of 7 registries used, show all original rules.

105

4. Check minimum number of events

None

105

5. Include endpoints

None

105

6. Filter based on genotype QC (FinnGen only)

105

Control definitions (FinnGen only)

Control exclude
ASTHMA_ALLERG

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L23
Name in latin
Eczema allergicum ex contactu nutrimentorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1444 806 635
Only index persons 1161 681 480
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.03 0.02
Median age at first event (years)
Whole population 15.11 23.09 4.90
Only index persons 19.59 26.47 9.83

-FinnGen-

Key figures

All Female Male
Number of individuals 105 77 28
Unadjusted period prevalence (%) 0.02 0.03 0.01
Median age at first event (years) 33.18 34.94 28.32

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
95
Matched controls
948
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L23.6
ICD-10 Finland
Allergic contact dermatitis due to food in contact with skin
+∞
134.9
95
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
14.9
24.6
45
54
XQ800
NOMESCO Finland
Prick test
16.8
20.1
33
29
L20.0
ICD-10 Finland
Besnier prurigo
8.4
14.2
34
59
C01CA24
ATC
epinephrine; parenteral
8.3
10.6
24
37
E0000UV
ATC
NA
3.8
9.0
59
285
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
10.6
9.0
17
19
XQ802
NOMESCO Finland
Epicutan test
10.1
8.8
17
20
J45.0
ICD-10 Finland
Predominantly allergic asthma
8.9
7.8
16
21
E000002
ATC
NA
4.8
7.6
27
73
J30.3
ICD-10 Finland
Other allergic rhinitis
11.4
7.3
13
13
E000001
ATC
NA
3.7
7.3
37
139
D07AC13
ATC
mometasone; topical
3.6
7.2
40
160
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
7.2
7.2
17
28
T78.4
ICD-10 Finland
Allergy, unspecified
6.4
6.7
17
31
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
19.6
6.4
9
5
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
19.6
6.4
9
5
L27.2
ICD-10 Finland
Dermatitis due to ingested food
19.6
6.4
9
5

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
12
27
4.89
5.18
3.7
3.4
135.8
133.6
g/l
0.15
12
27
10
25
4.32
3.79
4.3
2.4
24.6
23.8
mmol/l
—
10
25
5
5
10.40
3.01
1.2
1.2
—
—
—
0
0
7
13
5.68
2.92
6.6
2.8
—
—
—
0
0
7
13
5.68
2.92
4.0
2.5
6.2
6.8
mmol/l
—
7
13
7
13
5.68
2.92
4.0
2.5
1.3
1.2
mmol/l
—
7
13
91
751
2.59
2.88
2.9
3.3
1.2
1.3
mmol/l
0.64
85
704
93
788
2.58
2.55
3.0
3.5
1.5
1.5
mmol/l
0.11
88
744
14
59
2.58
2.41
2.4
1.3
497.2
513.3
u/ml
0.01
14
54
93
797
2.46
2.32
3.4
3.8
2.8
2.8
mmol/l
0.04
87
752
5
9
5.77
2.24
3.4
2.4
3.8
3.9
mmol/l
—
5
9
5
9
5.77
2.24
3.4
2.4
107.8
105.8
mmol/l
—
5
9
5
9
5.77
2.24
3.4
2.4
—
—
—
0
0
81
680
1.84
1.84
4.2
3.9
14.4
14.5
pmol/l
0.19
75
627
16
83
2.09
1.76
1.8
1.7
—
—
—
0
0
43
309
1.66
1.71
3.0
3.1
—
—
—
0
0
13
64
2.18
1.62
3.6
3.8
—
—
—
0
0
53
409
1.60
1.55
6.1
4.5
0.0
0.0
estimate
0.00
12
95
53
409
1.60
1.55
3.1
3.3
0.0
0.0
estimate
0.00
12
95
35
244
1.65
1.54
4.1
3.1
—
—
—
0
0
5
15
3.44
1.54
2.4
5.5
3.9
3.8
e9/l
—
5
15
5
15
3.44
1.54
2.4
5.5
57.6
57.9
%
—
5
15
11
52
2.25
1.50
1.6
1.2
—
—
—
0
0
14
75
2.00
1.42
1.0
1.3
—
—
—
0
0
53
415
1.56
1.42
3.7
3.3
0.0
0.0
estimate
0.00
11
91
6
24
2.59
1.32
1.2
1.2
—
—
—
0
0
5
19
2.71
1.23
3.8
5.6
—
—
—
0
0
11
57
2.04
1.22
3.5
3.7
—
0.6
%
—
0
11
42
322
1.51
1.19
2.0
2.4
—
—
—
0
0
10
51
2.06
1.15
4.4
2.0
—
—
—
0
0
95
876
1.89
1.09
11.8
11.5
15.4
20.0
mg/l
0.85
77
650
14
84
1.77
1.04
2.0
1.7
—
—
—
0
0
11
61
1.90
1.03
3.5
3.9
—
0.5
%
—
0
13
31
231
1.49
0.99
2.1
3.0
17.9
318.4
e6/l
0.56
24
180
7
37
1.95
0.96
6.6
1.9
—
—
—
0
0
28
206
1.49
0.95
2.2
2.7
0.3
0.2
e6/l
0.18
20
158
10
56
1.87
0.91
3.7
4.1
—
0.1
%
—
0
12
6
29
2.13
0.91
2.0
1.6
—
—
—
0
0
23
165
1.50
0.87
2.5
4.2
—
—
—
0
0
54
458
1.37
0.82
5.0
5.7
1.9
2.2
e9/l
0.81
49
415
6
33
1.87
0.80
3.7
18.7
—
—
—
0
0
29
223
1.42
0.78
2.1
1.3
2.5
2.1
g/l
0.73
21
135
5
23
2.23
0.77
1.2
1.1
—
—
—
0
0
14
92
1.60
0.77
1.0
1.2
—
—
—
0
0
29
224
1.41
0.76
3.2
4.8
1.1
1.0
inr
0.29
11
79
28
216
1.40
0.74
3.7
4.3
—
—
—
0
0
36
290
1.37
0.74
1.7
1.6
—
—
—
0
0
9
58
1.60
0.72
4.0
3.9
—
0.0
%
—
0
11
51
437
1.32
0.69
4.9
5.6
0.5
0.5
e9/l
0.00
45
395
83
765
1.41
0.68
11.7
13.8
13.4
13.5
%
0.32
83
751
51
438
1.32
0.68
5.0
5.6
0.0
0.0
e9/l
0.30
45
396
53
459
1.31
0.66
4.9
6.5
0.2
0.2
e9/l
0.34
48
419
86
799
1.42
0.65
11.5
14.1
333.6
333.4
g/l
0.06
86
794
5
30
1.70
0.62
3.2
1.9
—
—
—
0
0
34
279
1.32
0.61
2.9
3.4
11.6
36.7
e6/l
0.98
26
190
16
115
1.46
0.61
1.2
1.4
—
—
—
0
0
22
169
1.38
0.59
1.1
1.3
35.0
24.7
iu/ml
—
7
54
46
395
1.29
0.59
7.6
7.3
0.0
0.0
e9/l
0.50
39
323
96
919
1.52
0.56
10.9
10.3
—
—
—
0
0
6
39
1.57
0.54
1.0
1.2
—
—
—
0
0
63
571
1.26
0.50
3.9
4.2
—
—
—
0
0
7
48
1.49
0.48
1.1
3.4
—
—
—
0
0
20
158
1.33
0.46
1.4
1.6
—
—
—
0
0
57
514
1.24
0.46
7.0
9.8
3.6
4.0
e9/l
1.01
52
466
22
177
1.31
0.45
4.8
3.1
—
—
—
0
0
13
96
1.40
0.44
1.2
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
20.3
—
1671.7
—
0
15
0
15
0.00
0.41
0.0
11.5
—
887.7
—
0
15
0
15
0.00
0.41
0.0
2.9
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
28
237
1.25
0.39
4.3
2.6
9.9
17.5
ng/l
2.07
16
120
20
163
1.28
0.37
4.0
3.5
4.9
10.1
mg/mmol
0.62
11
100
87
840
1.21
0.25
11.1
12.0
39.1
40.5
%
0.67
77
691
24
211
1.18
0.23
2.5
2.6
—
—
—
0
0
10
79
1.29
0.23
1.1
1.4
—
—
—
0
0
34
308
1.15
0.23
1.9
1.9
—
—
—
0
0
5
39
1.30
0.23
1.6
9.3
24.1
24.5
mmol/l
—
5
39
13
107
1.25
0.23
1.8
2.5
—
—
—
0
0
26
231
1.17
0.22
1.6
1.8
—
—
—
0
0
5
41
1.23
0.22
2.0
1.9
—
—
—
0
0
5
42
1.20
0.22
2.8
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
153.4
—
0
12
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
6
48
1.26
0.20
3.0
9.0
—
—
—
0
0
6
48
1.26
0.20
1.0
1.5
—
—
—
0
0
53
499
1.13
0.20
2.9
2.9
—
—
—
0
0
6
51
1.19
0.20
1.7
1.4
—
—
—
0
0
6
51
1.19
0.20
1.7
1.4
—
—
—
0
0
22
246
0.87
0.19
1.7
2.4
—
—
—
0
0
27
297
0.88
0.18
1.8
2.1
—
—
—
0
0
20
177
1.16
0.18
2.3
3.1
—
—
—
0
0
10
82
1.24
0.18
2.3
3.1
—
—
—
0
0
5
67
0.73
0.17
2.0
1.6
—
—
—
0
0
10
83
1.23
0.16
1.3
1.5
—
—
—
0
0
9
109
0.81
0.13
2.1
2.1
—
—
—
0
0
24
220
1.12
0.13
2.4
3.8
0.0
0.0
estimate
0.00
12
90
10
85
1.20
0.13
1.6
1.5
—
—
—
0
0
17
153
1.13
0.12
3.4
2.9
31.9
66.6
mg/l
0.52
11
98
5
43
1.17
0.10
1.6
11.9
—
—
—
0
0
31
293
1.08
0.09
4.5
8.2
1.2
1.2
mmol/l
0.11
31
269
6
53
1.14
0.09
1.7
1.5
—
—
—
0
0
6
57
1.06
0.08
3.8
5.2
—
—
—
0
0
6
58
1.04
0.08
1.0
1.1
—
—
—
0
0
6
72
0.82
0.08
1.8
1.6
—
—
—
0
0
6
72
0.82
0.08
1.8
1.6
—
—
—
0
0
6
72
0.82
0.08
1.8
1.6
—
—
—
0
0
6
72
0.82
0.08
1.8
1.6
—
—
—
0
0
26
246
1.08
0.07
1.2
1.3
6.7
1.2
u/ml
—
7
64
18
193
0.92
0.07
1.6
1.8
—
—
—
0
0
73
716
1.06
0.06
4.0
4.2
38.6
38.0
mmol/mol
0.22
67
676
27
257
1.07
0.06
2.1
1.8
103.5
93.5
pmol/l
0.53
16
129
24
228
1.07
0.05
3.0
7.5
—
—
—
0
0
12
110
1.10
0.05
1.8
4.7
0.8
0.8
mmol/l
0.39
12
102
16
169
0.94
0.03
1.3
1.3
1.2
7.6
u/ml
—
10
74
15
157
0.95
0.01
1.5
1.5
—
—
—
0
0
21
217
0.96
0.01
2.4
2.5
—
—
—
0
0
28
275
1.02
0.00
5.1
5.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
92.4
—
0
9
9
99
0.90
0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
154.8
—
0
6
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
6
60
1.00
0.00
1.5
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
4.0
—
2.9
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
8.0
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
22.2
—
0
8
0
5
0.00
0.00
0.0
1.0
—
7.0
—
0
5
5
55
0.90
0.00
1.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint FOOD_ALLERGY and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have FOOD_ALLERGY.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: FOOD_ALLERGY – Food allergy

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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