Inflammatory myopathy

G6_INFLAMYOP

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G72.4
  • Cause of death: ICD-10 G72.4

2 out of 7 registries used, show all original rules.

57

4. Check minimum number of events

None

57

5. Include endpoints

None

57

6. Filter based on genotype QC (FinnGen only)

57

Control definitions (FinnGen only)

Control exclude
G6_MYONEU

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G72
Name in latin
Myopathia inflammatoria non alibi classificata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 383 177 205
Only index persons 356 166 190
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 72.29 72.78 71.86
Only index persons 72.51 73.14 71.96

-FinnGen-

Key figures

All Female Male
Number of individuals 57 28 29
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 74.97 74.25 75.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
57
Matched controls
570
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G72.4
ICD-10 Finland
Inflammatory myopathy, not elsewhere classified
+∞
78.9
56
*
M60.8
ICD-10 Finland
Other myositis
432.0
27.1
25
*
G72.9
ICD-10 Finland
Myopathy, unspecified
+∞
19.9
18
*
R13
ICD-10 Finland
Dysphagia
11.8
18.1
24
33
M60.9
ICD-10 Finland
Myositis, unspecified
217.3
16.4
16
*
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
199.0
15.3
15
*
G72.8
ICD-10 Finland
Other specified myopathies
199.0
15.3
15
*
NXL00
NOMESCO Finland
Biopsy of muscle
+∞
13.0
12
*
L28
ICPC
Limited function/disability (L)
6.8
12.0
30
80
JDB10
NOMESCO Finland
Percutaneous gastrostomy
119.0
9.7
10
*
SPAT1229
SPAT
Assessment of need for aid
8.9
8.7
19
30
M33.2
ICD-10 Finland
Polymyositis
104.9
8.7
9
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
26.7
8.4
11
5
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
52.5
8.0
9
*
L19
ICPC
Muscle symptom/complaint NOS
29.7
7.9
10
*
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
+∞
7.4
7
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.8
7.4
23
70
N28
ICPC
Limited function/disability (N)
34.9
7.4
9
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.5
6.9
25
85
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
26.2
6.9
9
*
TJD20
NOMESCO Finland
Change of gastrostomy tube
+∞
6.4
6
*
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
+∞
6.4
6
*
ZXD05
NOMESCO Finland
Urgent procedure
4.1
6.3
27
103
SPAT1215
SPAT
Assessment of need for medical rehabilitation
9.8
6.2
12
15
N18
ICPC
Paralysis/weakness
13.1
6.1
10
9

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
24
51
7.40
12.03
1.3
1.2
—
—
—
0
0
18
44
5.52
7.47
3.6
5.5
—
—
—
0
0
11
15
8.79
5.44
3.5
7.3
—
—
—
0
0
38
205
3.56
4.95
10.2
5.8
—
—
—
0
0
30
141
3.38
4.87
5.1
5.1
—
—
—
0
0
25
120
2.93
3.72
2.7
1.7
1228.79
1296.03
nmol/l
0.12
15
85
9
19
5.41
3.40
1.4
1.2
—
—
—
0
0
38
237
2.81
3.33
9.0
8.2
1.22
1.22
mmol/l
0.04
32
198
36
222
2.69
3.17
9.5
7.1
1.21
1.21
mmol/l
0.09
31
191
24
124
2.62
2.99
1.9
1.7
416.83
457.18
pmol/l
0.33
18
102
26
143
2.50
2.82
5.8
4.5
—
—
—
0
0
5
6
8.97
2.80
3.4
1.5
—
—
—
0
0
23
120
2.54
2.78
2.8
1.9
3.22
2.79
mg/l
0.31
18
105
36
232
2.50
2.75
16.8
14.1
1.28
1.26
inr
0.04
12
72
5
7
7.68
2.60
3.2
3.6
7.92
8.07
kpa
—
5
7
5
7
7.68
2.60
3.2
3.6
5.40
5.10
kpa
—
5
7
44
319
2.66
2.50
5.8
4.8
—
—
—
0
0
5
8
6.71
2.42
1.2
1.1
—
—
—
0
0
13
56
2.71
2.24
1.7
1.6
—
—
—
0
0
6
15
4.34
2.10
1.7
1.1
—
—
—
0
0
28
178
2.13
2.02
2.1
2.0
—
—
—
0
0
44
337
2.34
1.93
7.2
4.0
20.73
13.96
mm/h
1.45
37
297
8
31
2.83
1.73
3.4
2.1
12.04
9.34
g/l
—
8
26
12
58
2.35
1.63
1.2
1.3
—
—
—
0
0
22
138
1.97
1.57
3.0
3.1
0.52
0.18
e6/l
0.57
17
106
9
38
2.62
1.54
1.3
2.4
—
—
—
0
0
21
131
1.95
1.52
2.9
2.9
—
—
—
0
0
12
62
2.18
1.40
4.4
2.1
—
—
—
0
0
10
49
2.26
1.31
1.1
1.2
—
—
—
0
0
8
39
2.22
1.21
4.1
4.5
—
—
—
0
0
15
91
1.88
1.15
1.7
1.4
3.44
2.19
g/l
—
7
50
5
21
2.51
1.11
1.8
5.0
25.58
24.17
mmol/l
—
5
21
27
344
0.59
1.11
36.0
21.5
328.37
331.72
g/l
1.15
27
344
9
46
2.13
1.10
1.9
1.4
—
—
—
0
0
27
202
1.64
1.00
2.3
2.0
91.04
85.33
pmol/l
0.29
14
93
22
156
1.67
0.99
2.6
2.7
—
—
—
0
0
19
130
1.69
0.98
4.3
4.0
—
—
—
0
0
24
176
1.63
0.95
3.3
3.8
65.83
105.97
e6/l
0.35
19
131
21
149
1.65
0.94
2.3
3.2
6.71
6.94
mmol/l
0.06
12
120
20
142
1.63
0.89
2.4
3.3
106.54
506.78
mg/l
0.42
12
91
6
105
0.52
0.83
2.0
3.6
—
—
—
0
0
10
59
1.84
0.82
1.8
1.8
—
—
—
0
0
50
454
1.82
0.79
32.4
15.1
—
—
—
0
0
21
155
1.56
0.78
3.0
4.0
18.81
7.31
mg/mmol
—
10
96
51
467
1.87
0.70
28.6
19.3
68.78
83.66
umol/l
1.09
51
467
5
27
1.93
0.70
4.4
9.2
28.34
24.80
mmol/l
—
5
27
7
44
1.67
0.68
3.7
1.8
274.57
402.14
nmol/l
—
7
37
47
422
1.65
0.66
4.5
5.0
4.25
4.46
mmol/l
0.67
40
378
27
324
0.68
0.66
4.9
4.1
—
—
—
0
0
5
29
1.79
0.65
1.0
1.1
—
—
—
0
0
8
53
1.59
0.61
2.0
1.5
—
—
—
0
0
46
414
1.58
0.61
5.0
4.7
1.87
2.02
mu/l
0.50
41
357
23
182
1.44
0.60
19.7
10.3
0.00
0.00
e9/l
0.50
18
145
6
35
1.80
0.60
4.2
2.7
—
—
—
0
0
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
45
404
1.54
0.59
4.6
4.4
1.38
1.23
mmol/l
0.94
38
351
6
38
1.65
0.56
1.2
1.2
—
—
—
0
0
46
420
1.49
0.50
4.8
4.9
1.39
1.49
mmol/l
0.82
40
367
7
48
1.52
0.49
2.1
5.9
6.80
5.77
kpa
—
7
48
27
228
1.35
0.46
3.5
4.1
0.00
0.00
estimate
—
8
45
47
434
1.47
0.44
6.0
5.2
6.03
6.01
mmol/l
0.03
37
380
33
369
0.75
0.42
33.8
19.1
17.05
15.19
%
0.79
33
363
5
34
1.51
0.41
1.6
1.3
—
—
—
0
0
27
231
1.32
0.41
4.1
4.1
0.00
0.00
estimate
—
9
42
21
174
1.33
0.39
3.3
3.3
—
—
—
0
0
6
42
1.48
0.37
5.7
13.0
—
—
—
0
0
6
42
1.48
0.37
15.8
3.6
—
—
—
0
0
18
149
1.30
0.33
6.9
4.9
7.41
7.40
ph
—
6
23
47
441
1.37
0.32
5.1
5.6
2.51
2.56
mmol/l
0.14
41
385
26
227
1.27
0.32
5.3
5.7
0.00
0.00
estimate
—
9
42
21
179
1.27
0.31
3.3
3.9
—
5.72
—
0
9
9
115
0.74
0.31
2.4
3.3
—
—
—
0
0
14
115
1.29
0.27
9.0
6.4
—
—
—
0
0
5
37
1.38
0.24
1.2
1.7
—
—
—
0
0
5
42
1.21
0.22
2.6
4.0
5.74
3.90
kpa
—
5
42
15
174
0.81
0.21
6.8
5.7
2.05
2.32
ug/l
0.18
15
150
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
4.6
—
86.40
—
0
10
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
62.38
—
0
13
6
57
1.06
0.09
4.7
1.5
—
—
—
0
0
14
130
1.10
0.05
3.3
4.2
0.00
0.00
estimate
—
8
40
11
108
1.02
0.00
1.7
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
11.7
—
—
—
0
0
0
6
0.00
0.00
0.0
4.5
—
4.50
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
4.3
—
42.03
—
0
6
0
8
0.00
0.00
0.0
1.7
—
4.89
—
0
8
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.1
—
52.78
—
0
9
6
64
0.93
-0.00
5.5
8.7
103.67
103.42
mmol/l
—
6
64
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
7.04
—
0
5
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_INFLAMYOP and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_INFLAMYOP.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: G6_INFLAMYOP – Inflammatory myopathy

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data