No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
100 |
4. Check minimum number of eventsNone |
100 |
5. Include endpointsNone |
100 |
6. Filter based on genotype QC (FinnGen only) |
97 |
Control definitions (FinnGen only)
- Control exclude
- H8_OTHEREAR
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H92
- Name in latin
- Otorrhoea
Similar endpoints
↥List of similar endpoints to
Otorrhoea
based on the number of shared cases.
Similar with more cases:
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1405 | 620 | 781 |
| Only index persons | 922 | 434 | 488 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 14.43 | 23.40 | 7.15 |
| Only index persons | 38.46 | 44.95 | 32.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 97 | 64 | 33 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 55.09 | 52.14 | 60.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 100
- Matched controls
- 1000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H92.1
ICD-10 Finland
Otorrhoea
+∞
144.2
100
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
11.5
30.0
40
55
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
13.0
25.3
28
29
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
115.4
25.0
26
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
7.5
22.2
46
102
UDC00
NOMESCO Finland
Ear microscopy
23.0
21.4
31
19
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
58.9
20.2
23
5
H65.3
ICD-10 Finland
Chronic mucoid otitis media
22.1
19.9
29
18
H66.9
ICD-10 Finland
Otitis media, unspecified
5.9
14.1
32
74
H65.2
ICD-10 Finland
Chronic serous otitis media
40.4
14.0
17
5
DFF00
NOMESCO Finland
Pure tone audiometry
13.7
12.8
22
20
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
+∞
10.6
10
*
H04
ICPC
Ear discharge
17.0
10.4
16
11
H60.9
ICD-10 Finland
Otitis externa, unspecified
8.8
10.2
22
31
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
21.1
9.2
13
7
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
26.9
9.1
12
5
H71
ICD-10 Finland
Cholesteatoma of middle ear
55.0
8.8
10
*
DC1AD
NOMESCO Finland
Temporalbone CT
98.0
8.6
9
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
98.0
8.6
9
*
H65.0
ICD-10 Finland
Acute serous otitis media
13.3
8.4
14
12
TDA90
NOMESCO Finland
Removal wax from ear
49.0
7.8
9
*
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
49.0
7.8
9
*
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
12.2
7.5
13
12
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
86.2
7.5
8
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
7.4
7
*
H29
ICPC
Ear symptom/complaint other
4.2
6.9
21
60
H92.0
ICD-10 Finland
Otalgia
6.6
6.8
17
30
UDH02
NOMESCO Finland
Rhinopharyngoscopy
6.0
6.7
18
35
ZXA10
NOMESCO Finland
Bilateral
3.4
6.6
29
107
DCD00
NOMESCO Finland
Myringoplasty
74.4
6.5
7
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
6.3
6
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
6.3
6
*
H60.3
ICD-10 Finland
Other infective otitis externa
16.3
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
33
111
3.94
8.80
2.4
2.0
—
—
—
0
0
25
85
3.59
6.40
2.2
1.9
—
—
—
0
0
24
80
3.63
6.32
2.1
1.9
—
—
—
0
0
14
42
3.71
4.22
1.6
1.8
—
—
—
0
0
8
10
8.57
4.14
2.9
4.4
—
—
—
0
0
71
511
2.34
3.66
7.6
10.5
4.07
4.03
e9/l
0.06
58
440
7
9
8.26
3.62
2.9
4.8
9.43
6.78
%
—
7
9
6
7
9.02
3.31
1.8
4.4
25.00
29.43
%
—
6
7
9
22
4.39
2.96
1.9
2.3
—
—
—
0
0
77
604
2.19
2.79
5.2
3.9
13.45
11.77
mm/h
0.42
71
555
10
29
3.71
2.78
1.9
1.1
—
—
—
0
0
7
15
4.93
2.64
1.4
1.3
—
—
—
0
0
42
272
1.94
2.58
2.3
1.9
103.42
92.73
pmol/l
0.62
26
132
6
11
5.72
2.58
1.2
1.5
—
—
—
0
0
6
11
5.72
2.58
1.2
1.5
—
—
—
0
0
6
11
5.72
2.58
1.2
1.5
—
—
—
0
0
8
21
4.05
2.52
2.4
2.2
—
—
—
0
0
39
251
1.91
2.41
1.4
1.5
1.96
2.19
u/ml
—
9
47
46
314
1.86
2.37
15.1
11.0
1.21
1.18
inr
0.07
19
89
75
601
1.99
2.31
7.6
6.8
75.10
91.88
u/l
2.41
69
557
6
13
4.83
2.30
9.0
4.3
50.17
58.77
%
—
6
13
7
18
4.10
2.29
1.1
2.4
—
—
—
0
0
9
31
3.09
2.13
2.0
1.5
0.25
0.26
g/l
—
9
31
9
33
2.89
1.99
2.0
1.5
1.35
1.24
g/l
—
9
33
54
403
1.74
1.96
15.8
7.5
1.23
1.22
mmol/l
0.63
48
357
6
17
3.68
1.86
1.3
2.6
—
—
—
0
0
6
17
3.68
1.86
1.3
2.6
—
—
—
0
0
7
23
3.19
1.83
3.0
2.2
—
—
—
0
0
5
13
3.99
1.73
2.4
1.2
—
—
—
0
0
22
132
1.85
1.63
4.6
3.0
702.27
395.46
ng/l
0.29
15
97
36
257
1.63
1.45
4.8
3.9
17.26
29.15
ng/l
1.66
19
177
11
54
2.17
1.39
1.7
1.5
—
—
—
0
0
26
173
1.68
1.36
2.6
2.6
1.67
1.56
mg/l
0.04
20
135
31
217
1.62
1.34
4.4
3.6
15.18
13.99
mg/mmol
0.04
20
136
90
818
2.00
1.26
22.6
13.6
18.79
24.15
mg/l
0.93
74
611
16
96
1.79
1.19
2.4
2.3
—
—
—
0
0
25
171
1.62
1.17
2.5
2.8
—
—
—
0
0
5
20
2.58
1.16
2.0
1.4
—
—
—
0
0
18
113
1.72
1.15
1.6
1.7
770.84
1062.28
nmol/l
0.68
13
92
5
22
2.34
1.04
5.2
2.4
128.20
138.25
g/l
—
5
16
44
350
1.46
1.03
2.7
2.7
—
—
—
0
0
57
480
1.44
0.97
2.6
3.3
31.63
40.76
u/l
1.03
52
451
14
87
1.71
0.93
2.4
2.3
—
—
—
0
0
65
564
1.44
0.92
3.8
3.2
—
—
—
0
0
18
121
1.59
0.90
5.1
2.7
10.12
13.75
umol/l
2.04
18
114
75
672
1.46
0.86
4.4
3.9
1.33
1.23
mmol/l
0.78
68
615
77
695
1.47
0.83
4.9
4.3
1.47
1.50
mmol/l
0.23
72
638
10
58
1.80
0.83
1.9
2.0
—
—
—
0
0
77
699
1.44
0.77
5.1
4.4
4.68
4.64
mmol/l
0.12
72
647
15
101
1.57
0.75
5.4
3.0
17.47
23.93
%
2.03
15
92
37
300
1.37
0.74
5.9
3.9
—
—
—
0
0
16
110
1.54
0.74
5.4
2.8
2.26
2.44
g/l
0.69
16
102
5
25
2.05
0.74
2.8
2.0
—
—
—
0
0
9
58
1.61
0.72
15.6
4.7
1.22
1.23
mmol/l
—
9
52
14
94
1.57
0.71
11.2
5.7
-0.42
1.55
mmol/l
—
8
74
28
218
1.40
0.71
7.1
3.8
0.00
0.00
estimate
—
9
76
48
408
1.34
0.70
5.8
3.8
0.00
0.00
estimate
—
9
76
5
27
1.90
0.69
1.4
1.1
0.00
0.00
g/l
—
5
27
47
401
1.32
0.66
7.0
5.4
0.00
0.00
estimate
—
7
80
8
51
1.62
0.62
2.1
1.9
—
—
—
0
0
47
404
1.31
0.62
5.8
3.8
0.00
0.01
estimate
—
9
84
77
713
1.35
0.56
5.9
4.9
2.79
2.74
mmol/l
0.24
72
652
13
92
1.47
0.54
21.6
7.9
106.23
104.35
mmol/l
0.62
13
92
80
747
1.35
0.53
5.8
4.7
1.86
1.98
mu/l
0.51
75
688
14
101
1.45
0.53
18.4
9.5
23.75
25.13
mmol/l
0.49
14
101
27
219
1.32
0.53
2.3
1.7
—
—
—
0
0
9
65
1.42
0.52
3.9
3.4
—
—
—
0
0
12
84
1.49
0.52
23.3
7.3
5.03
5.16
kpa
0.18
12
79
12
84
1.49
0.52
23.2
7.3
14.50
11.62
kpa
0.63
12
79
12
85
1.47
0.49
23.2
7.3
-2.24
1.37
mmol/l
1.11
12
67
37
317
1.27
0.48
6.5
3.8
—
—
—
0
0
0
15
0.00
0.41
0.0
2.7
—
17.12
—
0
15
5
35
1.45
0.40
1.4
1.1
—
—
—
0
0
5
36
1.41
0.39
1.2
1.4
—
—
—
0
0
5
79
0.61
0.37
8.4
4.2
2.44
12.07
ug/l
—
5
64
6
41
1.49
0.37
3.2
4.1
44.75
47.09
%
—
6
41
18
146
1.28
0.35
4.1
4.4
25.92
21.76
%
—
6
75
6
44
1.39
0.35
5.5
2.9
0.17
0.10
e6/l
—
6
44
18
151
1.23
0.27
4.5
3.8
3.33
3.18
e6/l
0.03
12
89
70
665
1.18
0.26
20.3
12.6
78.18
82.78
ml/min/173m2
0.84
60
528
9
75
1.22
0.26
13.0
5.5
22.41
24.39
mmol/l
—
9
75
5
38
1.33
0.23
1.8
2.3
18.64
19.08
iu/l
—
5
29
5
39
1.30
0.23
1.8
4.0
1.40
1.25
%
—
5
39
5
40
1.26
0.23
1.2
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
4.3
—
—
—
0
0
0
10
0.00
0.21
0.0
3.9
—
—
—
0
0
0
10
0.00
0.21
0.0
4.3
—
—
—
0
0
0
12
0.00
0.21
0.0
4.8
—
108.14
—
0
12
9
113
0.78
0.21
3.1
3.1
0.52
0.68
ug/l
—
9
78
6
48
1.27
0.20
3.3
3.6
4.10
4.72
pmol/l
—
6
43
0
14
0.00
0.20
0.0
5.5
—
6.94
—
0
14
10
82
1.24
0.18
3.6
6.8
—
—
—
0
0
8
70
1.16
0.17
1.1
1.1
—
—
—
0
0
14
159
0.86
0.14
3.6
3.6
1.73
0.81
e6/l
—
8
97
6
72
0.82
0.08
1.2
2.5
26.83
32.08
u/l
—
6
61
14
128
1.11
0.07
1.9
1.4
—
—
—
0
0
25
263
0.93
0.06
8.2
3.9
0.67
0.31
e6/l
0.39
20
209
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
57.30
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
12.02
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
55
0.90
-0.00
2.2
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_OTORRHOEA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTORRHOEA | 1.491 [1.02, 2.18] | 0.04 |
| Birth year | 0.997 [0.99, 1.01] | 0.447 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 558 females with H8_OTORRHOEA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTORRHOEA | 1.271 [0.9, 1.79] | 0.173 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 707 males with H8_OTORRHOEA died.
Mortality risk
Mortality risk for people of age
years, who have H8_OTORRHOEA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.182% | 0.25% |
| 5 | 1.008% | 1.486% |
| 10 | 2.378% | 3.85% |
| 15 | 4.442% | 7.101% |
| 20 | 8.02% | 11.758% |
Relationships between endpoints
↥Index endpoint: H8_OTORRHOEA – Otorrhoea
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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