Otorrhoea

H8_OTORRHOEA

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H92.1 Cause of death: ICD-10 — H92.1 2 out of 7 registries used, show all original rules.	99
4. Check minimum number of events None	99
5. Include endpoints None	99
6. Filter based on genotype QC (FinnGen only)	99

Control definitions (FinnGen only)

Control exclude: H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H92
Name in latin: Otorrhoea

NAME	H8_OTORRHOEA
CONTROL_EXCLUDE	H8_OTHEREAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H921
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H921
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Otorrhoea based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1405	620	781
Only index persons	922	434	488
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	14.43	23.40	7.15
Only index persons	38.46	44.95	32.70

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	99	65	34
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	54.85	51.87	60.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
89: Matched controls
889

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H92.1

ICD-10 Finland

Otorrhoea

+∞

126.2

H72.0

ICD-10 Finland

Central perforation of tympanic membrane

107.8

23.0

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

90.2

19.7

H65.3

ICD-10 Finland

Chronic mucoid otitis media

17.8

16.5

UDC00

NOMESCO Finland

Ear microscopy

14.0

16.0

H66.0

ICD-10 Finland

Acute suppurative otitis media

7.6

14.5

DCA20

NOMESCO Finland

Insertion of ventilating tube through tympanic membrane

12.4

13.6

Z01.1

ICD-10 Finland

Examination of ears and hearing

6.9

11.7

H66.9

ICD-10 Finland

Otitis media, unspecified

6.9

11.1

H65.2

ICD-10 Finland

Chronic serous otitis media

25.4

11.1

H91.2

ICD-10 Finland

Sudden idiopathic hearing loss

+∞

9.5

DC1AD

NOMESCO Finland

Temporalbone CT

+∞

9.5

DFF00

NOMESCO Finland

Pure tone audiometry

12.1

9.5

H60.9

ICD-10 Finland

Otitis externa, unspecified

10.8

9.0

H72.9

ICD-10 Finland

Perforation of tympanic membrane, unspecified

99.0

8.6

H72.2

ICD-10 Finland

Other marginal perforations of tympanic membrane

99.0

8.6

H04

ICPC

Ear discharge

16.6

8.5

UDH02

NOMESCO Finland

Rhinopharyngoscopy

8.5

7.9

DCA10

NOMESCO Finland

Paracentesis of tympanic membrane

20.6

7.8

DCD00

NOMESCO Finland

Myringoplasty

+∞

7.4

H92.0

ICD-10 Finland

Otalgia

9.5

7.1

H66.3

ICD-10 Finland

Other chronic suppurative otitis media

18.5

6.9

H60.3

ICD-10 Finland

Other infective otitis externa

28.9

6.3

TDA90

NOMESCO Finland

Removal wax from ear

28.9

6.3

H70.1

ICD-10 Finland

Chronic mastoiditis

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

5.32

13.49

2.8

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

111

3.96

8.81

2.4

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.45

5.85

2.2

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.49

5.77

2.2

1.8

—

(3000494) Fungus identified in Specimen by Culture

3.12

5.02

2.1

1.5

—

(3042936) Bacteria identified in Isolate by Culture

2.95

4.56

2.5

1.9

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.72

4.19

1.8

2.2

—

(4062490)

8.58

4.14

2.5

1.4

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

10.63

4.07

1.4

1.1

—

(42870588) Differential panel, method unspecified - Blood

301

2.24

3.78

6.8

7.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.50

3.64

1.6

1.8

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

8.26

3.62

3.1

4.7

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

507

2.19

3.18

7.8

10.5

4.1

4.0

e9/l

0.03

436

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.72

3.14

1.9

1.1

—

(3019198) Lymphocytes [#/volume] in Blood

443

2.07

3.01

7.3

7.1

2.1

2.3

e9/l

0.39

385

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

264

2.03

2.87

2.2

1.9

102.3

93.3

pmol/l

0.48

127

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

6.30

2.74

1.2

1.5

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

6.30

2.74

1.2

1.5

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

6.30

2.74

1.2

1.5

—

(3013707) Erythrocyte sedimentation rate by Westergren method

598

2.17

2.70

5.2

3.9

13.6

11.6

mm/h

0.50

548

(3013115) Eosinophils [#/volume] in Blood

445

1.97

2.66

7.5

7.6

0.2

e9/l

0.34

383

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.85

2.65

1.1

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

4.93

2.65

1.4

1.3

—

(3006315) Basophils [#/volume] in Blood

436

1.95

2.64

7.4

7.0

0.0

e9/l

0.35

372

(3001604) Monocytes [#/volume] in Blood

438

1.94

2.58

7.4

6.9

0.6

e9/l

0.73

373

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

7.44

2.58

1.8

1.3

—

(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood

7.44

2.58

2.0

4.4

25.2

29.4

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

248

1.94

2.52

1.4

1.5

2.0

2.3

u/ml

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

3.86

2.42

2.4

2.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

4.34

2.40

1.1

2.3

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

4.84

2.30

9.0

4.6

50.2

57.7

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

4.84

2.30

5.2

3.3

3.1

4.7

e9/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

595

1.97

2.22

7.6

6.8

75.8

91.9

u/l

2.24

550

(3009508) Creatinine [Moles/volume] in Urine

232

1.87

2.19

4.6

3.5

6.3

7.8

mmol/l

2.00

200

(3006245) CD3-CD19+ cells/100 cells in Blood

5.20

2.09

2.0

4.1

14.8

7.7

—

(40768797) Stomach Pathology biopsy report

2.14

2.08

1.0

1.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

403

1.75

1.97

15.9

7.4

1.2

mmol/l

0.52

350

(3013512) EKG study

189

1.84

1.93

6.5

3.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

555

1.80

1.92

6.0

4.2

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.67

1.90

1.1

—

(3032080) INR in Blood by Coagulation assay

277

1.75

1.88

7.9

5.7

1.0

1.1

inr

1.11

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

4.33

1.84

2.4

1.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.19

1.83

3.0

2.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.39

1.82

1.7

1.5

—

(3019225) pH of Specimen

2.39

1.82

5.7

3.9

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

169

1.82

1.76

2.6

1.6

1.5

mg/l

0.03

130

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

129

1.91

1.75

4.7

3.0

767.7

407.6

ng/l

0.36

(3007164) IgA [Mass/volume] in Serum or Plasma

229

1.74

2.4

1.5

2.3

2.0

g/l

0.33

113

(3021901) Oxygen saturation in Capillary blood

3.29

1.69

4.3

5.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.12

1.60

1.8

1.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

253

1.66

1.56

5.7

3.9

17.5

28.9

ng/l

1.57

176

(3044889) 12 lead EKG panel

496

1.60

1.43

4.1

3.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

171

1.71

1.42

2.5

2.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

214

1.65

1.42

4.7

3.7

15.2

14.6

mg/mmol

0.02

130

(3012516) Albumin [Mass/volume] in Urine

200

1.64

1.33

3.8

3.0

54.1

393.3

mg/l

0.56

132

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

473

1.55

1.29

2.7

3.3

31.9

40.9

u/l

1.02

443

(3044640) Blood type and Crossmatch panel - Blood

229

1.59

1.26

2.4

2.7

—

(3011288) Drugs identified in Urine by Screen method

2.71

1.23

1.8

1.9

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

810

1.98

1.22

23.1

13.6

18.9

24.5

mg/l

0.95

607

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.80

1.19

2.4

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.77

1.15

10.1

5.5

4.8

5.1

kpa

1.09

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

345

1.50

1.13

4.0

4.1

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.35

1.13

2.3

1.5

0.3

g/l

—

(3000991) Gas panel - Venous blood

106

1.73

1.12

20.5

9.5

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.03

1.11

33.9

10.8

94.3

94.6

—

(1616796) Gas panel - Central venous blood

2.45

1.10

17.8

4.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.20

1.08

2.3

1.5

1.3

1.2

g/l

—

(3019309) Folate [Moles/volume] in Red Blood Cells

116

1.67

1.06

1.6

1.7

758.2

1068.0

nmol/l

0.73

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

2.34

1.04

2.0

1.5

41.8

38.2

nmol/l

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

2.34

1.04

5.2

2.4

128.2

138.3

g/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.96

1.04

1.2

1.3

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

2.07

1.02

1.9

2.0

1.5

1.6

g/l

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.72

1.01

10.7

5.7

-0.2

1.6

mmol/l

—

(36660697) Celiac disease serology panel - Serum

103

1.66

0.94

1.4

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.71

0.93

2.4

—

(3023368) Bacteria identified in Blood by Culture

199

1.49

0.91

6.2

4.8

—

(3025941) Bacteria identified in Stool by Culture

1.89

0.88

1.0

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

293

1.42

0.87

5.9

3.9

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

662

1.47

0.86

4.6

3.9

1.4

1.2

mmol/l

0.94

602

(3022948) Iron [Moles/volume] in Serum or Plasma

115

1.58

0.84

4.9

2.7

10.2

13.4

umol/l

1.58

107

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

685

1.47

0.83

5.1

4.3

1.5

mmol/l

0.31

625

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.81

0.83

1.9

2.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

560

1.40

0.83

3.8

3.2

—

(40758558) Short blood count panel - Blood

258

1.42

0.82

5.8

9.4

—

(3031040) Bacteria [#/volume] in Urine by Automated count

540

1.40

0.82

6.5

4.4

—

33.0

—

(3009261) Glucose [Presence] in Urine by Test strip

401

1.38

0.82

5.8

3.8

0.0

estimate

—

(3029937) Albumin [Presence] in Urine by Test strip

213

1.44

0.81

7.1

3.8

0.0

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

394

1.37

0.77

7.0

5.4

0.0

estimate

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.23

0.77

1.4

1.7

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

689

1.44

0.77

5.3

4.4

4.7

4.6

mmol/l

0.16

634

(3022145) Colonoscopy Study observation

1.66

0.75

1.3

1.2

—

(4034850)

2.14

0.75

14.0

16.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.90

0.75

1.9

2.4

—

(3035350) Ketones [Presence] in Urine by Test strip

396

1.36

0.74

5.8

3.8

0.0

estimate

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.05

0.74

2.8

2.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

120

0.55

0.73

1.6

1.9

—

(40768804) Tissue Pathology biopsy report

293

1.36

0.70

1.9

—

(3018418) pH of Serum or Plasma

229

1.38

0.68

7.8

3.9

7.4

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

1.53

0.66

5.4

3.0

17.6

23.6

1.67

(3004789) Transferrin [Mass/volume] in Serum or Plasma

105

1.51

0.64

5.5

2.8

2.3

2.4

g/l

0.53

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.62

0.62

2.1

1.9

—

(3020891) Body temperature

1.70

0.62

5.4

4.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.59

0.62

2.0

1.8

—

(3021589) Normoblasts [#/volume] in Blood

415

1.30

0.60

11.8

10.4

0.0

e9/l

0.80

331

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

215

1.35

0.60

2.3

1.7

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.76

0.59

24.3

9.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

702

1.36

0.58

6.1

4.8

2.8

2.7

mmol/l

0.27

638

(3011397) Hemoglobin [Presence] in Urine by Test strip

207

1.35

0.57

4.0

3.4

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.55

0.56

15.6

4.6

1.2

mmol/l

—

(4010399)

1.52

0.55

2.2

1.4

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

736

1.36

0.55

5.7

4.7

1.9

2.0

mu/l

0.52

673

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.51

0.55

23.3

7.3

5.0

5.1

kpa

0.14

(3027801) Oxygen [Partial pressure] in Arterial blood

1.51

0.55

23.2

7.3

14.5

11.6

kpa

0.64

(3003694) ABO and Rh group [Type] in Blood

232

0.73

0.54

2.2

1.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

101

1.45

0.53

18.4

9.5

23.7

25.1

mmol/l

0.48

101

(3003396) Base excess in Arterial blood by calculation

1.49

0.52

23.3

7.3

-2.2

1.4

mmol/l

1.10

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

316

1.27

0.49

6.5

3.8

—

(3022313) Gas panel - Capillary blood

1.48

0.48

9.3

5.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

205

1.29

0.45

6.6

3.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

159

1.32

0.45

1.8

1.9

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.49

0.44

1.0

1.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

141

1.34

0.44

4.1

4.5

25.9

21.4

—

(40768443) Skin Pathology biopsy report

1.64

0.43

1.4

1.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

650

1.26

0.43

20.5

12.7

78.1

82.8

ml/min/173m2

0.88

517

(3016879) Cocaine [Presence] in Urine

1.59

0.43

1.6

1.4

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.41

0.0

1.4

—

(3014599) Egg white IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.2

—

1.6

—

(3027008) Opiates [Presence] in Urine

1.49

0.41

1.6

1.4

—

(3028300) Cannabinoids [Presence] in Urine

1.49

0.41

1.6

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.40

0.0

3.8

—

55.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.45

0.40

1.6

1.3

—

(3027944) Amphetamines [Presence] in Urine

1.45

0.40

1.6

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

1.45

0.40

1.6

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.40

0.40

3.9

3.4

—

(40761536) Microorganisms panel - Urine sediment

1.38

0.39

14.8

3.9

—

(1761868) Lipid panel - Serum or Plasma

232

0.78

0.39

2.9

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.63

0.37

8.4

4.2

2.4

12.3

ug/l

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.49

0.37

3.2

4.1

44.8

45.6

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.46

0.36

5.5

2.9

0.2

0.1

e6/l

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.39

0.34

12.1

5.6

22.7

24.4

mmol/l

—

(36304419) Bacteria [Presence] in Urine

258

0.81

0.32

8.5

3.8

—

(40761535) Cells panel - Urine sediment

1.29

0.30

2.9

3.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

149

1.25

0.30

4.5

3.8

3.3

3.2

e6/l

0.03

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.37

0.24

1.2

1.4

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.33

0.23

1.8

2.3

18.6

19.1

iu/l

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.33

0.23

1.8

4.1

1.4

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

173

1.20

0.23

9.7

5.9

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.20

0.22

1.2

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.21

0.0

1.2

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.21

0.0

4.3

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.6

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.1

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.21

0.0

4.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.8

—

108.1

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.29

0.21

3.3

3.7

4.1

4.7

pmol/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.29

0.21

1.3

1.5

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

2.8

—

17.5

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.8

—

3.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.24

0.18

3.6

6.9

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.16

0.17

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.79

0.15

1.6

1.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

107

0.83

0.13

3.1

3.2

0.5

0.7

ug/l

—

(3030467) Casts [#/volume] in Urine by Automated count

261

0.89

0.13

8.5

3.9

0.7

0.3

e6/l

0.41

206

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

157

0.87

0.12

3.6

1.7

0.8

e6/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

126

1.13

0.09

1.9

1.3

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.82

0.08

1.2

2.6

26.8

32.1

u/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

132

0.90

0.07

2.3

1.6

—

(3002256) Pathology report gross observation

0.85

0.07

1.0

1.3

—

(3026008) Bacteria identified in Urine by Culture

257

1.07

0.06

3.6

2.7

—

(3009542) Hematocrit [Volume Fraction] of Blood

761

0.94

0.05

20.6

15.1

37.4

38.9

0.62

599

(40761511) CBC panel - Blood by Automated count

832

1.06

0.02

18.6

11.1

—

(3018095) Leukocytes [#/volume] in Urine

332

0.99

0.00

9.1

4.4

149.8

53.3

e6/l

0.40

234

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.1

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

4.3

—

26.1

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.9

—

(4027681)

0.00

0.0

1.0

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

163.0

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3000492) Spirometry study

0.90

0.00

1.5

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3011648) Oxygen content in Venous blood

0.00

0.0

6.6

—

12.7

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.8

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.1

—

(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.2

—

(4146454)

0.00

0.0

2.4

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

2.2

—

6.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.99

0.00

1.9

1.8

—

(3002621) Streptococcal DNAse B [Units/volume] in Serum

0.00

0.0

1.1

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(4035726)

1.00

0.00

1.3

1.4

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.2

—

(3012565) Volume of 24 hour Urine

0.00

0.0

2.8

—

2500.0

—

(4281824)

0.00

0.0

1.0

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.92

0.00

2.2

1.5

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.6

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.7

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

1.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.1

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.4

—

(21494755) Public health laboratory ask at order entry panel

0.85

0.00

1.0

1.3

—

(3045781) Inhibin B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

121.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

3.0

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.4

—

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

0.00

-0.00

0.0

1.0

—

(3045716) Anion gap in Serum or Plasma

0.00

-0.00

0.0

2.0

—

7.8

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.4

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.2

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

8.5

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.4

—

(3039429) Cortisol [Moles/volume] in Saliva (oral fluid)

0.00

-0.00

0.0

2.8

—

2.0

—

(3019083) Insulin-like growth factor [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

12.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

3.8

—

(3019977) pH of Arterial blood

0.00

-0.00

0.0

2.4

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.4

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_OTORRHOEA and mortality.

Females

Parameter	HR [95% CI]	p-value
H8_OTORRHOEA	1.491 [1.02, 2.18]	0.04
Birth year	0.997 [0.99, 1.01]	0.447

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 558 females with H8_OTORRHOEA died.

Males

Parameter	HR [95% CI]	p-value
H8_OTORRHOEA	1.271 [0.9, 1.79]	0.173
Birth year	0.988 [0.98, 1.0]	0.014

During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 707 males with H8_OTORRHOEA died.

Mortality risk

Mortality risk for people of age

years, who have H8_OTORRHOEA.

N-year risk	Females	Males
1	0.182%	0.25%
5	1.008%	1.486%
10	2.378%	3.85%
15	4.442%	7.101%
20	8.02%	11.758%

Relationships between endpoints

↥

Index endpoint: H8_OTORRHOEA – Otorrhoea

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Otorrhoea

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints