Interstitial cystitis (chronic), drug-induced

INTERSTITIAL_CYSTIT_CHRONIC

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs ANY
  • Hospital discharge: ICD-10 N30.1#

1 out of 7 registries used, show all original rules.

120

4. Check minimum number of events

None

120

5. Include endpoints

None

120

6. Filter based on genotype QC (FinnGen only)

118

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 118 105 13
Unadjusted period prevalence (%) 0.03 0.04 0.01
Median age at first event (years) 50.13 49.94 51.65

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
120
Matched controls
1200
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N30.1
ICD-10 Finland
Interstitial cystitis (chronic)
+∞
161.1
120
8
UKC02
NOMESCO Finland
Cystoscopy
34.3
88.8
88
89
KCV04
NOMESCO Finland
Distension of bladder with fluid
507.6
85.7
76
*
G04BD07
ATC
tolterodine; oral
17.5
49.7
50
47
G04BD04
ATC
oxybutynin; oral, transdermal
15.5
49.7
57
66
5951A
ICD-9 Finland
Cystitis, Chronic interstitial cystitis
+∞
34.0
31
*
7325
FHL
Bladder stretching
+∞
31.7
29
*
XKD00
NOMESCO Finland
Uroflowmetry
10.2
29.6
41
58
R35
ICD-10 Finland
Polyuria
10.0
24.7
33
44
59504
ICD-8 Finland
Cystitis, Interstitialis (Hunner)
237.6
20.2
20
*
1530
FHL
Urethrocystoscopy
46.8
19.4
23
6
TKD00
NOMESCO Finland
Dilatation of urethra
111.9
18.1
19
*
N30.0
ICD-10 Finland
Acute cystitis
5.2
16.8
49
141
J01MA06
ATC
norfloxacin; oral
4.8
15.1
49
152
ZX136
NOMESCO Finland
Intravesicalis
91.6
15.0
16
*
J01EA01
ATC
trimethoprim; systemic
4.4
14.4
70
292
N06CA01
ATC
amitriptyline and psycholeptics; systemic
5.4
14.1
34
82
G04BD
ATC
Drugs for urinary frequency and incontinence
157.0
13.8
14
*
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
45.6
13.5
16
*
KCV02
NOMESCO Finland
Cystoscopic balloon distension of bladder
+∞
11.6
11
*
N30.9
ICD-10 Finland
Cystitis, unspecified
5.4
11.6
26
58
L04AA01
ATC
[U] ciclosporin
28.3
11.5
15
6
N02AX02
ATC
tramadol; systemic, rectal
3.7
10.9
75
376
7321
FHL
TU biopsy, coagulation or laser
+∞
10.6
10
*
TKC20
NOMESCO Finland
Catheterisation of bladder
5.5
10.2
22
47
J01MA02
ATC
ciprofloxacin; systemic
3.4
9.9
72
367
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
5.1
9.8
23
53
P01BA02
ATC
hydroxychloroquine; oral
4.5
9.7
27
72
G04AC01, ,
ATC
9.0
9.6
20
26
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.3
9.5
64
309
UJF32
NOMESCO Finland
Coloscopy
3.4
9.4
51
216
R30.0
ICD-10 Finland
Dysuria
9.2
9.3
19
24
R30.1
ICD-10 Finland
Vesical tenesmus
20.6
9.2
13
7
G04BD01
ATC
emepronium; systemic
20.6
9.2
13
7
A03FA02
ATC
cisapride; oral, rectal
4.7
8.8
23
58
J01MA01
ATC
ofloxacin; systemic
4.5
8.7
24
63
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.1
8.6
57
269
N06AA09
ATC
amitriptyline; systemic
4.1
8.4
27
80
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
24.0
8.2
11
5
R01AD12
ATC
fluticasone furoate; nasal
3.1
7.9
49
221
XKD06
NOMESCO Finland
Physiologic investigation of micturition
9.9
7.8
15
17
A03CA02
ATC
clidinium and psycholeptics; oral
4.6
7.1
18
44
G44.2
ICD-10 Finland
Tension-type headache
3.5
6.9
27
91
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
3.0
6.9
40
172
ZXD10
NOMESCO Finland
Scheduled procedure
2.7
6.7
64
357
G03CA04
ATC
estriol; systemic, vaginal
3.5
6.5
25
83
90621, ,
NOMESCO Finland
73.6
6.5
7
*
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
12.0
6.4
11
10
G04BD11
ATC
fesoterodine; oral
7.8
6.4
14
20
7362
FHL
Urethral dilatation in anesthesia or operating room
+∞
6.3
6
*
KCC00
NOMESCO Finland
Cystectomy
+∞
6.3
6
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.7
6.3
51
260
A02BA02
ATC
ranitidine; systemic
2.8
6.2
39
174
J01CA08
ATC
pivmecillinam; oral
2.8
6.2
83
539
H43.8
ICD-10 Finland
Other disorders of vitreous body
3.6
6.1
22
70
M13.9
ICD-10 Finland
Arthritis, unspecified
4.2
6.1
17
45

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
22
71
3.57
5.98
5.0
5.1
—
—
—
0
0
63
377
2.41
5.31
4.7
3.4
—
—
—
0
0
37
195
2.30
3.97
5.1
3.9
574.78
154.03
ng/l
0.69
27
160
22
95
2.61
3.60
2.7
3.8
—
—
—
0
0
13
43
3.27
3.36
4.2
1.8
—
—
—
0
0
50
316
2.00
3.28
5.5
3.3
34.26
269.16
e6/l
0.60
43
243
46
284
2.00
3.21
9.2
4.4
0.00
0.00
estimate
-0.00
15
99
60
407
1.95
3.19
2.4
2.6
79.43
96.62
ug/l
0.65
55
373
11
32
3.68
2.99
1.5
2.8
—
—
—
0
0
29
159
2.09
2.75
6.0
2.8
3.58
3.70
e6/l
0.03
19
88
38
231
1.94
2.71
2.0
2.1
2.38
3.18
mg/l
1.33
33
203
13
51
2.74
2.54
7.2
3.8
25.28
24.90
mmol/l
0.17
13
51
38
238
1.87
2.46
8.3
4.1
—
—
—
0
0
27
151
2.02
2.42
2.0
3.1
0.84
0.80
mmol/l
0.97
27
134
68
516
1.73
2.26
8.0
4.3
0.00
0.00
estimate
-0.00
16
94
13
56
2.48
2.13
7.2
4.6
95.35
94.40
%
0.65
13
56
41
282
1.69
1.88
5.2
3.0
—
—
—
0
0
17
88
2.09
1.86
4.8
3.8
—
—
—
0
0
52
382
1.64
1.85
7.1
3.7
467.14
107.67
e6/l
0.48
45
266
5
12
4.30
1.84
1.2
2.6
87.48
57.67
%
—
5
12
58
440
1.62
1.80
7.3
5.8
—
—
—
0
0
84
702
1.66
1.73
7.4
4.8
—
—
—
0
0
65
512
1.59
1.70
9.0
5.9
0.00
0.00
estimate
-0.00
16
97
16
84
2.04
1.69
1.8
1.6
—
—
—
0
0
47
343
1.61
1.69
3.0
3.5
7.41
7.40
ph
—
8
65
13
63
2.19
1.67
1.1
1.2
37.92
169.66
iu/ml
—
6
28
65
516
1.57
1.62
8.2
4.3
0.00
0.00
estimate
-0.00
16
103
10
44
2.39
1.60
4.0
3.1
—
—
—
0
0
12
58
2.19
1.55
1.3
1.3
—
—
—
0
0
12
58
2.19
1.55
1.6
2.4
1.26
1.12
%
0.28
12
58
49
369
1.55
1.51
2.8
3.5
2.39
2.36
mmol/l
0.85
44
327
7
28
2.59
1.47
1.0
1.2
—
—
—
0
0
22
136
1.76
1.45
4.8
1.8
30.15
29.27
s
0.19
22
130
13
67
2.05
1.44
1.5
1.3
—
—
—
0
0
72
595
1.53
1.43
4.7
4.3
6.41
6.58
mmol/l
0.53
66
549
19
114
1.79
1.38
5.9
4.6
5.35
5.18
kpa
0.40
19
108
19
114
1.79
1.38
5.9
4.6
13.18
11.65
kpa
0.63
19
108
81
691
1.53
1.35
6.0
3.8
—
—
—
0
0
36
261
1.54
1.29
4.0
6.7
—
—
—
0
0
8
36
2.31
1.27
1.4
1.3
1.36
1.18
g/l
—
8
36
11
56
2.06
1.26
1.6
2.4
0.55
0.69
%
0.79
11
56
67
555
1.47
1.25
6.7
9.1
4.06
4.12
e9/l
0.07
61
492
17
102
1.78
1.24
2.1
2.3
5.40
7.74
umol/l
0.62
12
87
54
430
1.47
1.23
9.7
9.8
0.00
0.00
e9/l
0.80
47
349
5
19
2.70
1.23
1.2
1.7
—
—
—
0
0
5
19
2.70
1.23
1.0
1.6
—
—
—
0
0
5
19
2.70
1.23
4.8
3.2
47.00
63.16
%
—
5
19
13
73
1.88
1.16
2.8
6.2
9.31
9.00
mmol/l
0.05
13
66
7
30
2.41
1.14
3.9
1.9
—
—
—
0
0
59
484
1.43
1.12
12.3
14.8
1.24
1.24
inr
0.02
25
147
14
82
1.80
1.11
3.5
2.9
—
—
—
0
0
7
35
2.06
1.02
1.4
1.3
0.27
0.23
g/l
—
7
35
0
28
0.00
0.99
0.0
1.3
—
361.95
—
0
15
31
230
1.47
0.99
1.4
1.2
0.59
1.92
u/ml
—
10
61
21
143
1.57
0.98
1.3
1.2
—
—
—
0
0
63
533
1.38
0.96
5.9
5.2
1.22
1.23
mmol/l
0.33
55
454
87
779
1.42
0.93
5.7
4.3
14.99
14.86
pmol/l
0.21
81
695
17
112
1.60
0.91
2.9
3.9
1.06
1.08
mmol/l
0.15
17
97
51
426
1.34
0.81
6.1
5.2
0.59
0.66
%
0.40
51
390
10
59
1.76
0.78
1.1
1.6
—
—
—
0
0
0
27
0.00
0.78
0.0
1.0
—
1.30
—
0
20
0
27
0.00
0.78
0.0
1.2
—
27.82
—
0
22
5
23
2.22
0.77
4.6
2.2
—
—
—
0
0
5
23
2.22
0.77
1.0
1.7
—
—
—
0
0
49
410
1.33
0.76
6.3
4.2
35.12
35.05
ng/l
0.00
29
290
52
439
1.33
0.76
6.0
5.3
2.38
2.61
%
0.34
52
407
5
24
2.13
0.75
1.2
2.5
—
—
—
0
0
12
76
1.64
0.75
3.0
3.6
—
—
—
0
0
9
56
1.66
0.74
1.9
3.4
24.34
25.03
mmol/l
—
9
56
5
26
1.96
0.71
2.6
3.3
—
—
—
0
0
52
443
1.31
0.70
6.1
5.5
7.78
8.37
%
0.76
52
414
34
273
1.34
0.69
2.5
3.5
1.07
6.34
mg/mmol
2.72
22
158
26
200
1.38
0.68
1.5
1.4
2.07
2.50
g/l
0.54
16
113
5
29
1.75
0.64
1.0
1.1
—
—
—
0
0
8
53
1.55
0.60
4.0
2.3
—
—
—
0
0
23
178
1.36
0.59
1.4
1.3
38.13
10.60
u/ml
—
10
72
5
88
0.55
0.58
2.2
3.2
—
—
—
0
0
11
73
1.56
0.58
1.4
1.4
—
—
—
0
0
49
424
1.26
0.57
2.1
2.1
—
—
—
0
0
17
126
1.41
0.55
1.6
1.7
—
—
—
0
0
52
455
1.25
0.54
6.0
5.4
28.65
27.77
%
0.18
52
425
51
446
1.25
0.53
5.8
5.2
56.00
57.43
%
0.32
51
415
11
75
1.51
0.53
1.3
1.8
—
—
—
0
0
6
40
1.53
0.52
1.0
1.4
—
—
—
0
0
31
256
1.28
0.51
2.4
3.0
8.26
39.00
mg/l
1.83
20
157
50
438
1.24
0.51
2.3
2.0
111.38
98.04
pmol/l
0.76
18
206
83
887
0.79
0.51
4.5
4.1
1.47
1.23
mmol/l
1.09
78
803
23
183
1.32
0.50
1.5
1.3
17.60
43.05
iu/ml
—
5
65
26
312
0.79
0.45
3.0
3.0
—
—
—
0
0
8
55
1.49
0.44
1.6
1.2
—
—
—
0
0
7
103
0.66
0.41
1.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
15
115
1.35
0.41
2.0
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
2.6
—
—
—
0
0
88
926
0.81
0.39
5.5
4.6
4.62
4.70
mmol/l
0.30
82
850
15
116
1.33
0.39
1.8
1.4
—
—
—
0
0
31
265
1.23
0.39
1.5
1.5
24.36
21.30
nmol/l
0.40
25
219
32
275
1.22
0.38
4.3
3.8
—
—
—
0
0
26
305
0.81
0.37
7.3
3.8
—
—
—
0
0
16
128
1.29
0.34
1.5
1.3
284.44
556.36
titre
—
9
33
15
119
1.30
0.33
1.3
1.2
—
—
—
0
0
88
837
1.19
0.32
23.8
17.5
14.32
15.17
%
1.22
88
823
16
129
1.28
0.32
1.2
1.2
—
—
—
0
0
8
107
0.73
0.30
5.6
2.7
1.36
1.82
%
—
8
99
7
56
1.27
0.30
1.4
1.7
—
—
—
0
0
8
67
1.21
0.27
2.4
2.2
3.31
7.54
e9/l
—
8
55
9
74
1.23
0.26
1.2
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
32
290
1.14
0.21
5.5
4.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
93
955
0.88
0.17
6.1
5.1
2.70
2.72
mmol/l
0.07
86
872
91
935
0.89
0.17
5.6
4.6
5.85
5.89
mmol/l
0.19
86
857
10
83
1.22
0.16
7.4
3.9
—
—
—
0
0
7
87
0.79
0.15
2.3
5.7
1.99
2.77
ug/l
—
7
78
22
241
0.89
0.13
1.4
1.4
—
—
—
0
0
22
241
0.89
0.13
2.4
2.4
335.68
10961.11
umol/l
2.28
22
206
94
920
1.10
0.12
6.9
5.2
1.79
3.21
mu/l
0.55
89
836
6
58
1.04
0.08
3.5
4.9
—
—
—
0
0
6
70
0.85
0.08
11.7
3.1
58.33
71.51
e9/l
—
6
57
99
979
1.06
0.05
21.5
15.0
19.02
21.48
mg/l
0.46
86
772
12
112
1.08
0.03
1.3
1.5
—
—
—
0
0
104
1048
0.94
0.02
30.1
21.8
4.41
4.37
e12/l
0.38
99
1017
104
1048
0.94
0.02
29.8
21.7
39.43
39.19
%
0.18
99
988
23
223
1.04
0.01
1.7
1.8
496.11
480.57
pmol/l
0.08
18
182
10
94
1.07
0.01
1.2
1.5
—
—
—
0
0
99
996
0.97
0.00
18.3
14.0
—
—
—
0
0
15
146
1.03
0.00
1.9
1.7
—
—
—
0
0
101
1013
0.98
0.00
25.4
17.6
73.98
73.06
umol/l
0.16
101
1013
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
8.62
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
31.57
—
0
7
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
15.01
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
1.72
—
0
5
0
8
0.00
-0.00
0.0
3.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
11.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
31
310
1.00
-0.00
1.9
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
1.19
—
0
5
0
5
0.00
-0.00
0.0
5.0
—
38.60
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
106.20
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

Index endpoint: INTERSTITIAL_CYSTIT_CHRONIC – Interstitial cystitis (chronic), drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).