Interstitial cystitis (chronic), drug-induced

INTERSTITIAL_CYSTIT_CHRONIC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ATC codes for adverse effects of Drugs — ANY Hospital discharge: ICD-10 — N30.1# 1 out of 7 registries used, show all original rules.	120
4. Check minimum number of events None	120
5. Include endpoints None	120
6. Filter based on genotype QC (FinnGen only)	120

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	INTERSTITIAL_CYSTIT_CHRONIC
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC	ANY
HD_ICD_10	N301
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Interstitial cystitis (chronic), drug-induced based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	120	107	13
Unadjusted period prevalence (%)	0.03	0.04	0.01
Median age at first event (years)	50.11	49.92	51.65

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
100: Matched controls
999

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

N30.1

ICD-10 Finland

Interstitial cystitis (chronic)

+∞

133.7

100

KCV04

NOMESCO Finland

Distension of bladder with fluid

513.8

68.6

UKC02

NOMESCO Finland

Cystoscopy

32.9

48.7

G04BD04

ATC

oxybutynin; oral, transdermal

35.7

36.0

G04BD07

ATC

tolterodine; oral

26.9

29.8

5951A

ICD-9 Finland

Cystitis, Chronic interstitial cystitis

164.5

24.9

7325

FHL

Bladder stretching

147.5

22.6

XKD00

NOMESCO Finland

Uroflowmetry

11.9

18.9

1530

FHL

Urethrocystoscopy

108.6

17.2

59504

ICD-8 Finland

Cystitis, Interstitialis (Hunner)

+∞

17.2

R35

ICD-10 Finland

Polyuria

12.8

14.9

TKD00

NOMESCO Finland

Dilatation of urethra

40.4

14.0

G04BD

ATC

Drugs for urinary frequency and incontinence

+∞

12.8

N31.1

ICD-10 Finland

Reflex neuropathic bladder, not elsewhere classified

73.8

11.9

ZX136

NOMESCO Finland

Intravesicalis

67.4

10.9

L04AA01

ATC

[U] ciclosporin; systemic

36.9

10.6

KCV02

NOMESCO Finland

Cystoscopic balloon distension of bladder

+∞

10.6

J01MA02

ATC

ciprofloxacin; systemic

3.9

9.5

287

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

3.9

9.3

233

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.9

9.0

191

J01EA01

ATC

trimethoprim; systemic

3.5

8.2

234

J01MA06

ATC

norfloxacin; oral

4.0

8.0

122

TKC20

NOMESCO Finland

Catheterisation of bladder

7.1

7.9

XKD06

NOMESCO Finland

Physiologic investigation of micturition

11.4

7.8

UJF32

NOMESCO Finland

Coloscopy

3.7

7.7

165

TKW99

NOMESCO Finland

Other minor surgical procedure in urology

86.2

7.5

P01BA02

ATC

hydroxychloroquine; oral

5.8

7.4

7321

FHL

TU biopsy, coagulation or laser

+∞

7.4

KC1EE

NOMESCO Finland

Ultrasound measurement of residual urine

6.0

7.3

D13.1

ICD-10 Finland

Benign neoplasm: Stomach

22.0

7.3

A06AC01

ATC

ispaghula (psylla seeds); oral

3.4

7.2

189

R30.0

ICD-10 Finland

Dysuria

8.8

6.9

R30.1

ICD-10 Finland

Vesical tenesmus

43.1

6.9

N02AX02

ATC

tramadol; systemic, rectal

3.1

6.8

336

N06AA09

ATC

amitriptyline; systemic

4.5

6.7

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

3.3

6.7

174

A01AB09

ATC

miconazole; local oral

5.0

6.6

A02BA02

ATC

ranitidine; systemic

3.4

6.5

136

N06CA01

ATC

amitriptyline and psycholeptics; systemic

4.0

6.4

N32.82

ICD-10 Finland

Instability of the detrusor vesicae muscle

19.5

6.4

G04BD01

ATC

emepronium; systemic

19.5

6.4

90621

NOMESCO Finland

+∞

6.3

KCW96

NOMESCO Finland

Other operations on bladder

+∞

6.3

N06AX21

ATC

duloxetine; oral

5.0

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3000991) Gas panel - Venous blood

3.57

5.98

5.0

5.1

—

(3026008) Bacteria identified in Urine by Culture

371

2.39

5.20

4.7

3.4

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

195

2.30

3.97

5.1

3.9

574.8

154.0

ng/l

0.69

160

(3002032) Base excess in Venous blood by calculation

2.64

3.67

2.7

3.7

1.8

2.3

mmol/l

0.24

(3012544) pH of Venous blood

2.61

3.60

2.7

3.8

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

123

2.42

3.53

5.5

4.3

105.7

104.1

mmol/l

0.86

117

(3049717) Cytology report of Urine Cyto stain

3.68

3.42

1.5

2.8

—

(3045414) Leukocytes [Presence] in Urine

3.27

3.36

4.2

1.8

—

(3002582) Erythrocytes [#/volume] in Urine

316

2.00

3.28

5.5

3.3

34.3

269.2

e6/l

0.60

243

(3029937) Albumin [Presence] in Urine by Test strip

284

2.00

3.21

9.2

4.4

0.0

estimate

0.00

(3001122) Ferritin [Mass/volume] in Serum or Plasma

407

1.95

3.19

2.4

2.6

79.4

96.6

ug/l

0.65

373

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

4.77

3.18

2.9

3.0

—

(3000850) Epithelial cells [#/volume] in Urine

230

2.03

3.07

2.8

2.7

5.8

6.0

e6/l

0.05

207

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

8.62

2.77

1.4

1.8

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

8.62

2.77

1.4

1.8

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

8.62

2.77

1.4

1.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

358

1.86

2.76

5.8

3.1

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

159

2.09

2.75

6.0

2.8

3.6

3.7

e6/l

0.03

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

231

1.94

2.71

2.0

2.1

2.4

3.2

mg/l

1.33

203

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.80

2.63

2.6

1.5

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

5.67

2.57

1.7

2.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.74

2.54

7.2

3.8

25.3

24.9

mmol/l

0.17

(3011397) Hemoglobin [Presence] in Urine by Test strip

238

1.87

2.46

8.3

4.1

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

3.52

2.45

2.0

1.1

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

151

2.02

2.42

2.0

3.1

0.8

mmol/l

0.97

134

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

326

1.79

2.38

2.6

2.4

48.8

57.1

u/l

1.45

304

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.03

2.36

1.8

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

516

1.73

2.26

8.0

4.3

0.0

estimate

0.00

(3014007) Fractional oxyhemoglobin in Arterial blood

2.48

2.13

7.2

4.6

95.3

94.4

0.65

(3030467) Casts [#/volume] in Urine by Automated count

291

1.74

2.12

5.2

3.1

0.2

0.5

e6/l

1.18

220

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

100

2.07

1.99

1.9

1.7

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

2.18

1.96

2.1

3.4

74.2

64.4

ml/min/173m2

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

4.69

1.96

2.4

1.1

—

(36304419) Bacteria [Presence] in Urine

282

1.69

1.88

5.2

3.0

—

(40761535) Cells panel - Urine sediment

2.09

1.86

4.8

3.8

—

(3018095) Leukocytes [#/volume] in Urine

382

1.64

1.85

7.1

3.7

467.1

107.7

e6/l

0.48

266

(3019230) Fractional oxyhemoglobin in Venous blood

4.30

1.84

1.2

2.6

87.5

57.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

702

1.66

1.73

7.4

4.9

—

(3021601) Nitrite [Presence] in Urine by Test strip

512

1.59

1.70

9.0

5.9

0.0

estimate

0.00

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.04

1.69

1.8

1.6

—

(3018418) pH of Serum or Plasma

343

1.61

1.69

3.0

3.5

7.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

178

1.75

1.69

5.1

2.6

2.2

1.1

e6/l

0.30

105

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

2.19

1.67

1.1

1.2

37.9

169.7

iu/ml

—

(3035350) Ketones [Presence] in Urine by Test strip

515

1.57

1.64

8.2

4.3

0.0

estimate

0.00

(4306422)

3.68

1.63

1.2

1.0

—

(3020891) Body temperature

2.39

1.58

4.0

3.1

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.52

1.57

1.0

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

216

1.66

1.55

6.2

4.7

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.19

1.55

1.3

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.19

1.55

1.6

2.4

1.3

1.1

0.28

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

3.43

1.54

1.2

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

150

1.75

1.53

1.8

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

369

1.55

1.51

2.8

3.5

2.4

mmol/l

0.88

321

(3015736) pH of Urine

407

1.54

1.50

7.4

4.0

—

(1002224) Polysomnography panel

2.59

1.47

1.0

1.2

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

136

1.76

1.45

4.8

1.8

30.2

29.3

0.19

130

(3026389) Candida sp identified in Specimen by Organism specific culture

3.21

1.45

2.0

1.3

—

(4010399)

2.05

1.44

1.5

1.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

595

1.53

1.43

4.7

4.3

6.4

6.6

mmol/l

0.51

549

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

145

1.73

1.42

1.8

1.4

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.29

1.40

1.4

1.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

403

1.51

1.39

8.1

4.5

—

(3027801) Oxygen [Partial pressure] in Arterial blood

114

1.79

1.38

5.9

4.6

13.2

11.7

kpa

0.63

108

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

114

1.79

1.38

5.9

4.6

5.4

5.2

kpa

0.40

108

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.23

1.37

8.9

6.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.84

1.36

1.5

1.6

—

(3044889) 12 lead EKG panel

691

1.53

1.35

6.0

3.8

—

(40758558) Short blood count panel - Blood

261

1.54

1.29

4.0

6.7

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.31

1.27

1.4

1.3

1.4

1.2

g/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

555

1.47

1.25

6.7

9.1

4.1

e9/l

0.07

492

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

102

1.78

1.24

2.1

2.3

5.4

7.7

umol/l

0.62

(3021589) Normoblasts [#/volume] in Blood

430

1.47

1.23

9.7

9.8

0.0

e9/l

0.80

349

(3021901) Oxygen saturation in Capillary blood

2.70

1.23

1.2

1.7

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.70

1.23

4.8

3.2

47.0

63.2

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

2.70

1.23

1.0

1.6

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

2.56

1.16

1.2

1.0

—

(3020779) Urea [Moles/volume] in Serum or Plasma

1.88

1.16

2.8

6.2

9.3

9.0

mmol/l

0.05

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

189

1.55

1.12

1.3

1.4

—

(3022621) pH of Urine by Test strip

1.80

1.11

3.5

2.9

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.44

1.10

1.2

1.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.85

1.05

1.4

1.8

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.33

1.04

1.2

1.5

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.06

1.02

1.4

1.3

0.3

0.2

g/l

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.93

1.00

1.8

3.2

48.4

43.3

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.99

0.0

1.3

—

361.9

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

230

1.47

0.99

1.4

1.2

0.6

1.9

u/ml

—

(40768797) Stomach Pathology biopsy report

143

1.57

0.98

1.3

1.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

533

1.38

0.96

5.9

5.2

1.2

mmol/l

0.34

449

(3014051) Protein [Presence] in Urine by Test strip

2.28

0.95

3.5

1.9

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

779

1.42

0.93

5.7

4.3

15.0

14.9

pmol/l

0.21

695

(3003458) Phosphate [Moles/volume] in Serum or Plasma

112

1.60

0.91

2.9

3.9

1.1

mmol/l

0.15

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.98

0.85

2.0

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.92

0.83

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.75

0.82

1.3

—

(3022096) Basophils/100 leukocytes in Blood

426

1.34

0.81

6.1

5.2

0.6

0.7

0.42

390

(42870588) Differential panel, method unspecified - Blood

304

1.37

0.79

5.9

5.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.76

0.78

1.1

1.6

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.78

0.0

1.0

—

1.3

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.78

0.0

1.2

—

27.8

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

2.22

0.77

1.0

1.7

—

(1616796) Gas panel - Central venous blood

2.22

0.77

4.6

2.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

410

1.33

0.76

6.3

4.2

35.1

35.2

ng/l

0.00

289

(3024928) Oxygen saturation in Venous blood

2.13

0.75

1.2

2.5

—

(3019060) Gas panel - Arterial blood

1.64

0.75

3.0

3.6

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.66

0.74

1.9

3.4

24.3

25.0

mmol/l

—

(3019069) Monocytes/100 leukocytes in Blood

442

1.31

0.72

6.1

5.5

7.8

8.4

0.80

413

(3052851) Hemolysis interference index of Serum or Plasma

1.96

0.71

2.6

3.3

—

(3043409) Potassium [Moles/volume] in Arterial blood

1.71

0.69

3.7

2.1

3.8

mmol/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

273

1.34

0.69

2.5

3.7

1.1

6.3

mg/mmol

2.72

158

(3007164) IgA [Mass/volume] in Serum or Plasma

200

1.38

0.68

1.5

1.4

2.1

2.5

g/l

0.54

113

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.75

0.64

1.0

1.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.64

0.63

1.5

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.58

0.61

1.4

—

(3002385) Erythrocyte distribution width [Ratio]

802

1.31

0.61

23.0

18.0

13.8

0.07

788

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.55

0.60

4.0

2.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

178

1.36

0.59

1.4

1.3

38.1

10.6

u/ml

—

(3019225) pH of Specimen

0.55

0.58

2.2

3.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.70

0.57

1.2

1.5

—

(40768804) Tissue Pathology biopsy report

424

1.26

0.57

2.1

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.65

0.56

1.0

1.7

—

(3002030) Lymphocytes/100 leukocytes in Blood

454

1.26

0.55

6.0

5.4

28.7

27.8

0.17

417

(46235355) HIV 1 and 2 tests - Meaningful Use set

126

1.41

0.55

1.6

1.7

—

(3018010) Neutrophils/100 leukocytes in Blood

445

1.25

0.55

5.8

5.2

56.0

57.4

0.32

412

(3000492) Spirometry study

1.51

0.53

1.3

1.8

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.53

0.52

1.0

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.53

0.52

2.0

1.9

—

(3012516) Albumin [Mass/volume] in Urine

256

1.28

0.51

2.4

3.0

7.8

39.0

mg/l

1.86

156

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

438

1.24

0.51

2.3

2.0

111.4

98.0

pmol/l

0.76

206

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

887

0.79

0.51

4.5

4.1

1.5

1.2

mmol/l

1.09

803

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

183

1.32

0.50

1.5

1.3

17.6

43.0

iu/ml

—

(3032080) INR in Blood by Coagulation assay

401

1.24

0.49

7.3

9.4

1.2

inr

0.23

123

(1761868) Lipid panel - Serum or Plasma

312

0.79

0.45

3.0

—

(3025941) Bacteria identified in Stool by Culture

1.49

0.44

1.6

1.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.64

0.43

3.8

2.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.54

0.42

1.4

1.2

—

(4035726)

103

0.66

0.41

1.0

1.3

—

(40768795) Lymph node Pathology biopsy report

0.00

0.41

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.7

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.1

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.1

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.41

0.0

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

115

1.35

0.41

2.0

1.5

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.41

0.0

1.0

—

(3023183) Ammonium ion [Moles/volume] in Plasma

0.00

0.40

0.0

4.1

—

23.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.40

0.0

1.8

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.40

0.0

2.6

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

926

0.81

0.39

5.5

4.6

4.7

mmol/l

0.28

849

(3000494) Fungus identified in Specimen by Culture

116

1.33

0.39

1.8

1.4

—

(3021960) Folate [Moles/volume] in Serum or Plasma

265

1.23

0.39

1.5

24.4

21.3

nmol/l

0.40

219

(3023368) Bacteria identified in Blood by Culture

275

1.22

0.38

4.3

3.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

108

1.34

0.37

4.3

4.0

—

(3013512) EKG study

305

0.81

0.37

7.2

3.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

118

1.31

0.35

20.5

7.0

—

(3037522) Nuclear Ab [Titer] in Serum

128

1.29

0.34

1.5

1.3

284.4

567.5

titre

—

(3002256) Pathology report gross observation

119

1.30

0.33

1.3

1.2

—

(3022145) Colonoscopy Study observation

129

1.28

0.32

1.2

—

(3027945) Reticulocytes/100 erythrocytes in Blood

107

0.73

0.30

5.6

2.7

1.4

1.8

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.27

0.30

1.4

1.7

—

(3017732) Neutrophils [#/volume] in Blood

1.21

0.27

2.4

2.2

3.3

3.8

e9/l

—

(36660697) Celiac disease serology panel - Serum

1.23

0.26

1.2

1.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.33

0.23

2.2

2.1

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.21

0.0

1.3

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.1

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

290

1.14

0.21

5.5

4.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.6

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.6

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.24

0.20

1.2

1.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.20

0.0

1.7

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.20

0.0

1.7

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.20

0.0

1.7

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.20

0.0

1.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.21

0.20

1.2

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.76

0.17

1.0

1.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

955

0.88

0.17

6.1

5.1

2.7

mmol/l

0.06

871

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

935

0.89

0.17

5.6

4.6

5.8

5.9

mmol/l

0.19

857

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.12

0.16

1.8

2.2

—

(40761536) Microorganisms panel - Urine sediment

1.22

0.16

7.4

3.9

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

916

1.12

0.15

6.9

5.2

1.8

3.2

mu/l

0.55

831

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

0.79

0.15

2.3

5.7

2.0

2.8

ug/l

—

(3026493) Urate [Moles/volume] in Serum or Plasma

241

0.89

0.13

2.4

343.5

11065.3

umol/l

2.28

204

(3003694) ABO and Rh group [Type] in Blood

241

0.89

0.13

1.4

—

(3000330) Specific gravity of Urine by Test strip

1.04

0.08

3.5

4.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.06

0.08

1.7

1.9

—

(3023520) Reticulocytes [#/volume] in Blood

0.85

0.08

11.8

3.1

58.3

71.5

e9/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

557

0.94

0.08

3.2

2.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

447

1.05

0.05

4.4

4.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

979

1.06

0.05

21.5

15.0

19.0

21.5

mg/l

0.47

772

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

112

1.08

0.03

1.3

1.5

—

(3026361) Erythrocytes [#/volume] in Blood

104

1048

0.94

0.02

30.1

21.8

4.4

e12/l

0.37

1017

(40761511) CBC panel - Blood by Automated count

998

0.95

0.02

18.3

14.0

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

223

1.04

0.01

1.7

1.8

496.1

480.6

pmol/l

0.08

182

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

917

0.97

0.01

20.3

14.2

78.5

76.8

ml/min/173m2

0.31

747

(3009542) Hematocrit [Volume Fraction] of Blood

843

1.03

0.01

18.7

15.3

39.5

38.8

0.38

599

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.07

0.01

1.2

1.5

—

(3042936) Bacteria identified in Isolate by Culture

146

1.03

0.00

1.9

1.8

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

101

1013

0.98

0.00

25.4

17.6

74.0

73.1

umol/l

0.16

101

1013

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

217

1.02

0.00

2.2

2.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.7

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

3.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.1

—

(44813793)

0.00

0.0

1.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.0

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

1.7

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

2.5

—

13.6

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.0

—

(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood

0.00

0.0

1.4

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.5

—

(3044640) Blood type and Crossmatch panel - Blood

310

1.00

0.00

1.9

2.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

15.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.5

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

3.0

—

537.8

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

0.0

10.5

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

3.5

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

5.0

—

38.6

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.1

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

0.0

1.0

—

106.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.0

—

11.2

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(4146454)

0.00

0.0

3.1

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

31.6

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.8

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

0.0

2.4

—

1.2

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

11.7

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

1.1

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.7

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.1

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

1.3

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.7

—

(3030558) Cytomegalovirus DNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.2

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

8.6

—

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: INTERSTITIAL_CYSTIT_CHRONIC – Interstitial cystitis (chronic), drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Interstitial cystitis (chronic), drug-induced

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Interstitial cystitis (chronic), drug-induced (INTERSTITIAL_CYSTIT_CHRONIC)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints