Supernumerary teeth EXCLUDE clefts and syndromes

K11_SUPNUM_ONLY

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions not K11_SUPNUM_EXCLUDE	519729
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — K00.1 Cause of death: ICD-10 — K00.1 2 out of 7 registries used, show all original rules.	160
4. Check minimum number of events None	160
5. Include endpoints None	160
6. Filter based on genotype QC (FinnGen only)	160

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze: DF5

NAME	K11_SUPNUM_ONLY
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS	!K11_SUPNUM_EXCLUDE
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K001
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K001
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Supernumerary teeth EXCLUDE clefts and syndromes based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3723	1455	2264
Only index persons	3237	1262	1975
Unadjusted period prevalence (%)
Whole population	0.05	0.04	0.06
Only index persons	0.06	0.05	0.08
Median age at first event (years)
Whole population	10.23	10.55	9.98
Only index persons	10.76	11.25	10.45

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	160	84	76
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	14.46	14.38	14.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
145: Matched controls
1449

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K00.10

ICD-10 Finland

The incisor and canine region, including the mesiodens

2046.3

100.7

K00.11

ICD-10 Finland

Excess teeth in the premolar region

+∞

24.7

K00.19

ICD-10 Finland

Indefinite redundant teeth

+∞

23.6

EBA10

NOMESCO Finland

Surgical removal of tooth

5.3

18.1

223

K00.12

ICD-10 Finland

Excess teeth in the molar region

102.1

17.0

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

7.4

9.7

EBA12

NOMESCO Finland

Complicated surgical removal of tooth

6.6

9.4

K01.0

ICD-10 Finland

Embedded teeth

9.6

9.1

ECA00

NOMESCO Finland

Surgical exposure of tooth

31.7

7.2

EB1AI

NOMESCO Finland

Cone beam imaging of teeth and jaws (one quarter)

10.8

6.7

SAA04

NOMESCO Finland

Special inverstigation of mouth

4.1

6.7

K00.1

ICD-10 Finland

Supernumerary teeth

72.9

6.5

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3032080) INR in Blood by Coagulation assay

294

2.02

3.86

6.8

4.6

1.1

inr

0.05

104

(3016616) Dehydroepiandrosterone sulfate (DHEA-S) [Moles/volume] in Serum or Plasma

5.58

2.90

2.1

1.3

4.4

5.2

umol/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

279

1.85

2.89

3.2

4.3

—

(40761511) CBC panel - Blood by Automated count

148

1315

2.67

2.88

13.0

8.5

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.29

2.79

14.7

6.6

1.1

1.4

mmol/l

0.17

(3007853) Bacteria identified in Skin by Aerobe culture

127

2.15

2.79

1.6

—

(3044640) Blood type and Crossmatch panel - Blood

342

1.77

2.74

2.8

2.4

—

(3021788) Differential panel - Synovial fluid

6.18

2.72

1.2

1.6

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

2.80

2.69

1.1

1.5

5.6

3.9

mg/l

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.32

2.63

2.2

3.3

10.9

10.0

g/l

0.28

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

435

1.69

2.58

3.2

2.7

71.8

70.6

nmol/l

0.12

397

(3008757) Leukocyte morphology finding [Identifier] in Blood

5.62

2.56

1.5

7.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

273

1.79

2.53

2.9

2.5

19.2

38.2

ng/l

0.47

114

(3042936) Bacteria identified in Isolate by Culture

125

2.08

2.52

2.1

2.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

113

2.10

2.39

1.1

1.3

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

6.41

2.39

4.8

3.0

69.0

45.3

umol/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

702

1.60

2.25

8.9

8.7

3.8

4.1

e9/l

0.60

601

(3028026) IgM [Mass/volume] in Serum or Plasma

2.29

2.23

1.5

2.1

1.2

1.0

g/l

0.47

(3013115) Eosinophils [#/volume] in Blood

626

1.60

2.22

7.9

7.6

0.2

e9/l

0.02

557

(3001604) Monocytes [#/volume] in Blood

607

1.60

2.22

7.8

7.0

0.5

0.6

e9/l

0.18

522

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.42

2.22

1.8

2.0

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.33

2.19

2.3

5.6

0.2

0.3

—

(3006315) Basophils [#/volume] in Blood

609

1.59

2.17

7.8

6.9

0.0

e9/l

0.15

527

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

139

1236

1.95

2.17

15.8

10.3

18.9

20.8

mg/l

0.30

111

897

(3022313) Gas panel - Capillary blood

2.23

2.11

17.9

7.4

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

5.12

2.08

1.2

1.3

—

(3019198) Lymphocytes [#/volume] in Blood

646

1.55

2.00

7.6

6.8

2.1

2.0

e9/l

0.11

577

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

4.65

1.95

3.2

7.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

434

1.57

1.94

12.8

8.7

1.2

mmol/l

0.10

377

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.95

1.89

2.8

1.8

—

(3044290) Cell count panel - Cerebral spinal fluid

2.95

1.89

1.5

4.1

—

(3017181) Myelocytes/100 leukocytes in Blood

2.16

1.87

2.3

5.3

1.2

0.8

—

(3002256) Pathology report gross observation

110

1.94

1.83

1.3

1.2

—

(4034850)

3.13

1.82

2.0

8.7

—

(1761868) Lipid panel - Serum or Plasma

404

1.55

1.80

2.3

2.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

533

1.52

1.79

5.3

4.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

150

1.79

1.76

1.3

1.4

—

(3002179) Metamyelocytes/100 leukocytes in Blood

2.16

1.76

2.5

4.9

0.4

0.5

—

(3023368) Bacteria identified in Blood by Culture

199

1.69

1.74

4.4

4.6

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

1.99

1.73

3.8

2.8

30.9

30.7

0.03

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.47

1.71

1.7

—

(42870588) Differential panel, method unspecified - Blood

408

1.53

1.71

8.5

7.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

262

1.59

1.62

2.9

2.4

—

(3000963) Hemoglobin [Mass/volume] in Blood

154

1458

2.50

1.62

20.9

14.5

137.0

138.2

g/l

0.49

154

1442

(3035941) MCH [Entitic mass]

154

1457

2.52

1.61

20.7

14.2

29.8

0.13

154

1440

(3024731) MCV [Entitic volume]

154

1457

2.52

1.61

20.7

14.2

88.9

88.7

0.12

154

1441

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

3.08

1.59

3.0

1.6

—

(3013707) Erythrocyte sedimentation rate by Westergren method

789

1.46

1.55

5.8

3.7

7.5

8.0

mm/h

0.25

731

(3015736) pH of Urine

471

1.48

1.55

3.6

2.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

109

943

1.49

1.53

4.7

3.5

14.3

14.6

pmol/l

0.69

102

857

(4306422)

2.93

1.52

1.0

1.2

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

2.57

1.47

4.1

4.6

3.0

3.7

e9/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.57

1.47

4.1

4.8

46.7

53.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.19

1.45

1.4

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

287

1.52

1.43

1.7

1.5

100.4

96.0

pmol/l

0.22

154

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

2.15

1.42

4.4

3.5

1.2

mmol/l

0.20

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.86

1.39

22.4

12.7

24.6

24.8

mmol/l

0.09

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

124

1112

1.51

1.36

5.0

4.0

1.9

1.8

mu/l

0.63

115

1047

(3000991) Gas panel - Venous blood

1.80

1.33

11.0

13.3

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

115

0.42

1.31

1.2

2.5

2.4

mmol/l

—

102

(4035726)

1.95

1.21

1.2

1.6

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.36

1.20

1.7

1.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

113

1008

1.41

1.17

3.2

2.8

5.4

5.6

mmol/l

0.71

106

924

(3027315) Oxygen [Partial pressure] in Blood

2.55

1.16

5.0

4.4

9.4

9.5

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.55

1.16

5.0

4.4

5.2

5.0

kpa

—

(3013512) EKG study

186

1.54

1.16

3.9

2.5

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.31

1.12

1.4

1.5

—

(3002032) Base excess in Venous blood by calculation

106

1.68

1.08

10.0

8.4

0.8

1.6

mmol/l

0.33

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.17

1.07

9.0

18.7

0.6

0.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

118

1069

1.40

1.05

3.6

3.1

2.6

2.8

mmol/l

1.61

113

1004

(3012544) pH of Venous blood

107

1.66

1.04

10.0

8.5

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.11

1.04

9.0

18.2

1.0

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

270

1.43

1.03

1.9

1.6

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

2.21

0.98

2.0

1.6

—

(1616796) Gas panel - Central venous blood

2.21

0.98

4.2

4.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

142

1.55

0.98

2.4

2.0

—

(3047181) Lactate [Moles/volume] in Blood

0.00

0.97

0.0

19.1

—

1.2

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

1.93

0.95

1.1

1.2

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

103

0.47

0.93

2.4

1.6

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.80

0.92

2.1

1.4

—

(3052851) Hemolysis interference index of Serum or Plasma

2.19

0.92

3.7

2.8

—

(3018418) pH of Serum or Plasma

249

1.41

0.92

4.9

3.5

7.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

340

1.36

0.91

5.4

3.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

111

1006

1.34

0.91

11.2

7.9

104.1

101.9

ml/min/173m2

0.47

766

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

764

1.30

0.89

10.3

6.0

94.6

82.1

u/l

1.21

714

(3029937) Albumin [Presence] in Urine by Test strip

296

1.37

0.88

3.9

3.3

0.2

0.0

estimate

0.44

112

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.04

0.88

2.5

2.8

64.3

49.9

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

1.65

0.87

1.3

1.5

321.0

279.6

miu/ml

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

486

0.74

0.87

2.2

1.7

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

113

1.56

0.86

1.4

1.3

168.9

115.0

iu/ml

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

137

1288

1.44

0.85

11.5

7.7

28.1

26.8

u/l

0.28

132

1247

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.64

0.81

2.2

2.4

—

(3022145) Colonoscopy Study observation

100

1.55

0.76

1.9

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

267

1.35

0.75

2.5

3.1

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

2.12

0.75

2.4

2.3

92.0

277.1

ug/l

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.03

0.73

2.2

1.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

170

1.41

0.72

2.2

3.4

0.8

e6/l

0.04

104

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.78

0.72

1.6

2.1

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

1.95

0.71

1.0

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.95

0.71

1.0

1.2

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

1.95

0.71

1.2

1.0

—

(40768804) Tissue Pathology biopsy report

372

1.29

0.70

2.4

1.8

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

1.88

0.69

1.4

1.1

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

137

1.44

0.68

14.4

3.6

4.6

9.4

umol/l

0.88

116

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.66

0.67

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

134

1268

1.35

0.67

13.7

11.4

41.1

40.9

0.21

122

1089

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

1.81

0.66

2.2

2.6

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.62

0.66

1.9

1.2

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

1.60

0.61

1.8

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.5

—

(3002385) Erythrocyte distribution width [Ratio]

122

1147

1.27

0.59

15.9

12.8

13.3

13.1

0.74

122

1127

(3000494) Fungus identified in Specimen by Culture

1.47

0.59

2.0

—

(3019225) pH of Specimen

1.50

0.55

8.7

3.7

—

(4010399)

1.55

0.54

1.1

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

144

1.36

0.53

1.7

1.8

—

(3044889) 12 lead EKG panel

627

1.21

0.53

2.0

2.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

433

1.23

0.52

2.0

1.8

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.52

0.52

1.7

1.9

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

1.52

0.52

1.2

1.5

—

(3002582) Erythrocytes [#/volume] in Urine

303

1.24

0.49

4.5

3.7

7.8

59.3

e6/l

1.63

234

(3030467) Casts [#/volume] in Urine by Automated count

275

1.25

0.49

2.9

3.7

0.2

0.3

e6/l

0.40

207

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

433

0.81

0.49

2.9

2.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

284

0.78

0.47

3.5

2.1

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.42

0.45

3.0

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.48

0.45

1.0

1.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

104

1.38

0.45

1.3

1.7

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

177

1.28

0.43

1.4

1.3

10.3

24.2

iu/ml

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

1.42

0.43

3.9

2.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.58

0.42

1.0

1.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

394

1.20

0.42

1.6

1.5

2.1

2.0

g/l

0.37

226

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

1.53

0.41

3.2

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

300

1.21

0.41

1.7

—

(3003338) MCHC [Mass/volume]

125

1196

1.21

0.40

16.1

12.4

334.4

335.2

g/l

0.54

125

1183

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

1.40

0.38

1.0

1.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

583

1.16

0.38

4.7

4.4

0.0

estimate

0.00

114

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

474

0.85

0.37

3.0

2.7

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.30

0.37

7.6

17.1

4.7

5.1

kpa

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.30

0.37

7.6

17.1

16.6

16.1

kpa

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.44

0.36

1.2

2.5

36.0

94.1

ng/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.39

0.35

4.3

5.2

—

(3009508) Creatinine [Moles/volume] in Urine

295

1.19

0.35

4.2

3.7

7.6

8.7

mmol/l

0.76

266

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.38

0.35

1.0

1.1

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

1.38

0.35

1.2

2.0

37.3

36.8

u/l

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

1.32

0.33

1.5

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

579

1.15

0.32

3.8

3.1

0.0

estimate

0.00

112

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

232

1.20

0.31

2.9

2.6

0.9

1.4

mg/l

0.50

157

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

1.31

0.31

1.1

1.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

167

1.23

0.30

2.3

3.6

8.1

3.3

e6/l

0.45

101

(40758558) Short blood count panel - Blood

290

1.17

0.30

9.0

8.3

—

(3021589) Normoblasts [#/volume] in Blood

587

0.88

0.29

12.3

8.8

0.0

e9/l

0.62

467

(3000492) Spirometry study

118

0.75

0.28

1.2

1.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

203

0.82

0.28

3.6

3.4

302.3

7364.4

umol/l

1.05

185

(3018095) Leukocytes [#/volume] in Urine

389

1.14

0.27

5.0

4.2

12.7

40.7

e6/l

1.36

248

(3022621) pH of Urine by Test strip

1.25

0.26

1.7

1.9

—

(3009261) Glucose [Presence] in Urine by Test strip

588

1.12

0.25

3.5

3.2

0.0

estimate

0.00

109

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

136

0.79

0.24

1.0

1.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

387

0.88

0.24

2.3

1.8

—

(3048689) Calprotectin [Mass/mass] in Stool

248

1.16

0.23

2.5

2.4

144.1

78.0

ug/g

0.38

187

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

1.26

0.23

3.9

3.3

20.6

21.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.74

0.23

2.1

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

433

1.12

0.23

4.1

2.9

—

(21494755) Public health laboratory ask at order entry panel

183

1.17

0.21

1.3

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.2

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.6

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.27

0.21

1.1

1.4

—

(40761995) Spermatozoa Progressive [#/volume] in Semen

0.00

0.21

0.0

2.7

—

(3014043) Spermatozoa Nonprogressive/100 spermatozoa in Semen

0.00

0.21

0.0

5.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

798

0.91

0.20

6.4

3.9

—

(3045414) Leukocytes [Presence] in Urine

1.26

0.20

1.0

1.3

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.3

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.6

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.8

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

165

1.17

0.20

1.4

1.5

—

(40761536) Microorganisms panel - Urine sediment

118

1.20

0.20

2.7

3.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

566

1.10

0.18

2.3

2.2

—

(36304419) Bacteria [Presence] in Urine

282

1.12

0.18

3.1

3.7

—

(3000764) Benzodiazepines [Presence] in Urine

176

1.16

0.18

1.5

1.7

—

(3025941) Bacteria identified in Stool by Culture

1.12

0.16

2.0

1.2

—

(36660697) Celiac disease serology panel - Serum

182

0.87

0.16

1.2

—

(3005033) Fetal Nuchal fold Thickness US

0.77

0.15

2.0

1.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.77

0.15

2.0

1.3

—

(3003694) ABO and Rh group [Type] in Blood

463

1.08

0.14

2.0

1.7

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

232

0.89

0.14

3.1

1.9

—

(3027008) Opiates [Presence] in Urine

180

1.13

0.14

1.5

1.6

—

(3026008) Bacteria identified in Urine by Culture

278

1.10

0.13

1.4

2.1

—

(3028300) Cannabinoids [Presence] in Urine

181

1.12

0.13

1.5

1.6

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

114

1.15

0.12

1.7

1.6

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.17

0.12

3.5

2.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

174

1.10

0.10

5.4

4.2

5.0

18.5

mg/mmol

1.70

120

(3016879) Cocaine [Presence] in Urine

164

0.91

0.08

1.5

1.7

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.07

0.07

1.8

2.2

—

16.9

—

(3008898) HLA-B27 [Presence]

0.86

0.07

1.0

1.1

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.85

0.07

1.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.83

0.07

1.4

1.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.88

0.07

1.6

1.7

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

152

0.91

0.06

1.4

2.9

140.6

342.5

ng/l

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

109

1.11

0.06

1.7

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

109

1.11

0.06

1.7

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

109

1.11

0.06

1.7

1.4

—

(40768797) Stomach Pathology biopsy report

110

0.90

0.05

2.0

1.2

—

(3027944) Amphetamines [Presence] in Urine

179

1.07

0.05

1.5

1.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

121

1.08

0.04

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

139

0.93

0.03

1.4

1.8

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

179

0.94

0.03

1.4

1.3

1.0

8.8

u/ml

—

(3041096) Erythrocytes [Presence] in Urine by Automated

339

0.97

0.02

3.8

2.7

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

461

1.03

0.02

1.5

1.4

0.5

1.5

u/ml

1.93

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

124

1247

0.98

0.01

3.7

3.9

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

126

1.03

0.00

1.8

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

109

1.01

0.00

1.7

1.4

—

(3012516) Albumin [Mass/volume] in Urine

171

0.99

0.00

4.5

3.5

32.6

111.0

mg/l

1.66

115

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

241

1.00

0.00

1.3

1.4

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

107

1.03

0.00

2.8

2.6

30.4

27.3

u/l

0.18

(3050129) First trimester maternal screen panel - Serum or Plasma

133

0.98

0.00

1.7

1.4

—

(3011288) Drugs identified in Urine by Screen method

123

0.97

0.00

1.6

2.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

213

0.98

0.00

1.7

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.06

0.00

2.0

1.8

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.7

—

762.3

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

3.7

—

102.4

—

(3040370) OLANZapine [Moles/volume] in Serum or Plasma

0.00

0.0

1.7

—

181.9

—

(3011648) Oxygen content in Venous blood

0.00

0.0

15.9

—

14.6

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.4

—

6.2

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1556.9

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3025378) Microscopic observation [Identifier] in Cervix by Cyto stain

0.00

0.0

1.1

—

(4211845)

0.00

0.0

1.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.92

0.00

1.2

1.7

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

12.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3041365) Herpes simplex virus IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(40761535) Cells panel - Urine sediment

0.95

0.00

7.0

2.4

—

(3028707) Methadone [Presence] in Urine by Screen method

0.97

0.00

1.4

2.1

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

1.7

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.5

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.6

—

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

0.00

0.0

1.2

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.2

—

(21494429) FMR1 gene CGG repeat analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3001964) Herpes simplex virus Ag [Presence] in Specimen

0.00

0.0

2.5

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.5

—

(3011897) Casein IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.4

—

8.1

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

0.0

1.2

—

87.7

—

(40758990) Choriogonadotropin.beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(40759040) C peptide [Moles/volume] in Serum or Plasma --post meal

0.00

0.0

1.0

—

1.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.98

0.00

1.0

1.3

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.5

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.6

—

(42868647) JC virus Ab [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3018993) Complement total hemolytic CH100 [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.95

0.00

2.1

1.7

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

1.9

—

(44816808) CXCL13 Ag [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint K11_SUPNUM_ONLY and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_SUPNUM_ONLY.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: K11_SUPNUM_ONLY – Supernumerary teeth EXCLUDE clefts and syndromes

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Supernumerary teeth EXCLUDE clefts and syndromes

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints