Foreign body granuloma of skin and subcutaneous tissue

L12_FOREIGNBODYGRANULOMA

granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L92.3 Hospital discharge: ICD-9 — 7094 Cause of death: ICD-10 — L92.3 Cause of death: ICD-9 — 7094 2 out of 7 registries used, show all original rules.	121
4. Check minimum number of events None	121
5. Include endpoints None	121
6. Filter based on genotype QC (FinnGen only)	121

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L92
Name in latin: Granuloma cutis vel telae subcutaneae ex corpore alieno

NAME	L12_FOREIGNBODYGRANULOMA
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L923
HD_ICD_9	7094
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L923
COD_ICD_9	7094
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Foreign body granuloma of skin and subcutaneous tissue based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1088	532	551
Only index persons	970	472	498
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	42.35	44.17	40.60
Only index persons	42.59	44.60	40.67

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	121	68	53
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	47.10	45.01	49.78

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
113: Matched controls
1131

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L92.3

ICD-10 Finland

Foreign body granuloma of skin and subcutaneous tissue

+∞

125.6

7094A

ICD-9 Finland

Other disorders of skin and subcutaneous tissue, Foreign body granuloma of skin and subcutaneous tissue

+∞

18.2

QCE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in upper limb

17.2

7.4

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

3.07

5.42

2.4

1.4

—

(3022096) Basophils/100 leukocytes in Blood

439

2.11

3.93

5.8

0.7

0.32

410

(3006504) Eosinophils/100 leukocytes in Blood

450

2.10

3.87

7.0

5.9

2.9

0.02

423

(3041096) Erythrocytes [Presence] in Urine by Automated

268

2.16

3.85

5.8

3.0

—

(3018010) Neutrophils/100 leukocytes in Blood

460

2.09

3.84

6.3

5.9

53.8

56.5

1.06

437

(3019069) Monocytes/100 leukocytes in Blood

456

2.05

3.67

8.2

6.1

8.5

8.4

0.05

430

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

136

2.38

3.59

1.6

1.8

—

(3002030) Lymphocytes/100 leukocytes in Blood

470

2.02

3.52

6.9

6.0

31.3

29.0

1.02

442

(3013115) Eosinophils [#/volume] in Blood

491

2.01

3.45

7.0

6.2

0.2

e9/l

0.15

443

(3037467) Urinalysis macro (dipstick) panel - Urine

662

2.12

3.40

7.3

4.1

—

(3019198) Lymphocytes [#/volume] in Blood

488

1.96

3.26

6.3

6.0

2.0

e9/l

0.11

440

(3001604) Monocytes [#/volume] in Blood

474

1.93

3.11

6.2

5.9

0.6

e9/l

0.65

413

(3006315) Basophils [#/volume] in Blood

475

1.92

3.08

6.3

5.9

0.0

e9/l

0.13

419

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

103

2.39

3.03

1.5

1.7

—

(3000850) Epithelial cells [#/volume] in Urine

184

2.09

3.01

7.1

2.3

4.0

4.8

e6/l

0.29

163

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.41

2.98

1.5

1.6

—

(3032080) INR in Blood by Coagulation assay

365

1.80

2.54

23.0

6.5

1.4

1.2

inr

0.45

100

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.00

2.51

1.4

1.3

—

(42870588) Differential panel, method unspecified - Blood

317

1.79

2.38

7.0

5.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

709

1.81

2.22

6.0

4.3

11.0

11.4

mm/h

0.09

653

(1001926) Buprenorphine [Presence] in Urine by Screen method

3.16

2.20

2.2

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

2.86

2.16

1.6

1.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

335

1.72

2.12

5.8

2.9

—

(3027008) Opiates [Presence] in Urine

2.78

2.06

2.1

1.3

—

(3028300) Cannabinoids [Presence] in Urine

2.78

2.06

2.2

1.3

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

4.15

2.06

1.2

2.0

—

(3035350) Ketones [Presence] in Urine by Test strip

476

1.67

2.06

5.5

3.7

0.0

estimate

0.00

(3009261) Glucose [Presence] in Urine by Test strip

486

1.67

2.05

5.3

3.8

0.0

estimate

0.00

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

374

1.68

2.04

6.0

3.6

—

(3002582) Erythrocytes [#/volume] in Urine

294

1.72

2.03

6.6

2.9

13.3

268.2

e6/l

0.59

221

(3019150) Specific gravity of Urine by Refractometry

210

1.79

1.99

5.4

4.1

1.0

kg/l

—

(3027944) Amphetamines [Presence] in Urine

2.71

1.97

2.2

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

2.71

1.97

2.1

1.3

—

(40768443) Skin Pathology biopsy report

2.78

1.91

1.0

1.2

—

(3042936) Bacteria identified in Isolate by Culture

132

1.92

1.91

1.9

1.8

—

(3021601) Nitrite [Presence] in Urine by Test strip

475

1.63

1.86

7.3

5.1

0.0

estimate

0.00

(3044290) Cell count panel - Cerebral spinal fluid

3.66

1.86

1.5

1.1

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.66

1.86

1.2

2.1

—

(3016879) Cocaine [Presence] in Urine

2.69

1.84

2.2

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

717

1.69

1.83

4.3

3.9

14.4

14.8

pmol/l

0.89

660

(4094501)

3.16

1.83

1.3

1.2

—

(40761536) Microorganisms panel - Urine sediment

2.20

1.78

8.3

3.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

202

1.72

1.71

1.7

1.6

1.2

mg/l

0.26

156

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

3.68

1.63

1.2

1.9

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

3.68

1.63

1.0

1.1

—

(3013512) EKG study

275

1.62

1.60

4.2

3.4

—

(3018095) Leukocytes [#/volume] in Urine

339

1.58

1.56

7.1

3.6

14.8

72.1

e6/l

1.60

234

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

2.15

1.49

1.1

1.3

—

28.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.59

1.47

1.7

2.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

437

1.52

1.46

12.4

6.5

1.2

mmol/l

0.02

376

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

665

1.54

1.43

3.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.50

1.41

1.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.69

1.38

1.2

1.8

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.69

1.38

1.2

1.9

—

(3022313) Gas panel - Capillary blood

2.18

1.33

18.7

2.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

570

1.49

1.33

7.0

10.4

3.9

4.0

e9/l

0.03

497

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

341

1.51

1.32

3.0

3.9

23.5

41.0

ng/l

0.65

233

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

363

1.48

1.25

2.0

1.8

101.6

98.6

pmol/l

0.20

173

(3026008) Bacteria identified in Urine by Culture

272

1.52

1.24

5.0

2.9

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.56

1.16

1.4

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

215

1.53

1.12

5.3

5.2

—

(3049717) Cytology report of Urine Cyto stain

2.33

1.12

2.7

2.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.12

1.04

1.3

1.1

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.33

1.04

25.6

1.7

21.8

23.6

mmol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.75

1.03

2.5

2.9

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

134

1.59

1.00

8.7

3.2

0.8

mmol/l

0.35

126

(3011288) Drugs identified in Urine by Screen method

2.28

0.95

2.5

1.6

—

(36304419) Bacteria [Presence] in Urine

259

1.43

0.94

5.6

2.8

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.20

0.93

2.0

3.5

—

(3030467) Casts [#/volume] in Urine by Automated count

260

1.43

0.92

5.8

2.9

0.2

0.3

e6/l

0.49

189

(3020682) Albumin/Creatinine [Ratio] in Urine

282

1.39

0.85

4.1

3.7

3.9

8.2

mg/mmol

1.01

170

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.79

0.84

1.0

1.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.79

0.84

1.9

3.0

1.0

1.3

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

743

1.37

0.84

7.8

7.6

78.0

77.3

u/l

0.05

702

(3019309) Folate [Moles/volume] in Red Blood Cells

166

1.48

0.83

1.4

1.6

1152.0

1183.1

nmol/l

0.05

126

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.79

0.82

1.0

—

(3000330) Specific gravity of Urine by Test strip

1.71

0.80

2.0

3.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.78

0.0

1.6

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

2.22

0.77

1.0

1.1

—

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

109

1.54

0.75

2.5

1.5

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.75

0.71

2.1

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.70

0.71

18.9

2.5

5.1

4.9

kpa

—

(3044640) Blood type and Crossmatch panel - Blood

312

1.32

0.66

2.1

2.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

105

991

1.45

0.65

19.3

12.7

24.3

23.5

mg/l

0.08

778

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

157

1.41

0.65

1.0

1.3

20.9

32.6

iu/ml

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

158

1.40

0.62

2.4

2.8

0.5

1.0

e6/l

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

1.69

0.62

2.6

5.0

32.8

29.5

mg/l

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.60

0.0

1.6

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

151

1.39

0.59

2.5

2.8

1.5

3.2

e6/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

151

1.39

0.59

2.1

1.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.59

0.57

1.8

1.4

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

234

1.31

0.57

1.3

3.1

1.0

u/ml

0.53

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

104

987

1.38

0.55

5.3

4.7

2.8

mmol/l

0.03

919

(3023368) Bacteria identified in Blood by Culture

236

1.30

0.53

4.3

4.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.42

0.52

2.4

1.7

—

(3012516) Albumin [Mass/volume] in Urine

267

1.27

0.49

4.0

2.9

29.2

60.3

mg/l

0.86

162

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

211

1.30

0.49

1.4

1.6

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.46

0.49

1.5

2.2

13.2

13.8

nmol/l

0.10

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

460

1.23

0.48

5.1

4.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

221

1.29

0.48

1.5

1.3

2.4

2.2

g/l

0.27

119

(3019225) pH of Specimen

1.42

0.44

3.8

4.7

—

(3047181) Lactate [Moles/volume] in Blood

1.64

0.43

10.8

5.4

1.1

1.3

mmol/l

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.64

0.43

2.0

1.6

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.64

0.43

1.0

1.3

—

(3022217) INR in Platelet poor plasma by Coagulation assay

105

1.38

0.43

17.0

23.9

1.0

1.1

inr

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.59

0.43

1.4

1.3

—

(3025941) Bacteria identified in Stool by Culture

1.36

0.41

1.5

1.2

—

(3018418) pH of Serum or Plasma

273

1.23

0.41

6.0

4.2

7.4

—

(3021589) Normoblasts [#/volume] in Blood

437

1.20

0.41

8.2

8.7

0.0

e9/l

0.52

350

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.45

0.40

6.6

5.6

24.4

mmol/l

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.33

0.40

1.6

3.5

4.7

pmol/l

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.40

0.0

2.4

—

53.8

—

(40768797) Stomach Pathology biopsy report

136

1.29

0.36

1.3

1.2

—

(1761868) Lipid panel - Serum or Plasma

357

1.18

0.32

2.6

2.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.34

0.31

1.3

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

234

1.20

0.30

2.3

2.0

—

(3044889) 12 lead EKG panel

659

1.15

0.27

3.6

—

(3003694) ABO and Rh group [Type] in Blood

264

0.84

0.26

1.7

1.4

—

(3000492) Spirometry study

1.28

0.25

1.3

1.4

—

(3012544) pH of Venous blood

1.29

0.25

10.6

2.9

—

(3022948) Iron [Moles/volume] in Serum or Plasma

147

0.80

0.25

7.0

2.2

11.6

13.7

umol/l

0.90

130

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

162

1.21

0.24

1.1

1.3

22.1

11.0

u/ml

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.33

0.23

10.4

4.1

0.9

1.6

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.26

0.22

3.2

1.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

108

1055

1.22

0.21

20.9

14.7

76.6

75.1

umol/l

0.23

108

1055

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

10.1

—

835.6

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.21

0.0

1.6

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

17.0

—

1279.7

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3024139) IgG subclass 3 [Mass/volume] in Serum

0.00

0.21

0.0

1.1

—

0.5

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

2.5

—

(4062490)

0.00

0.21

0.0

1.1

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

4.5

—

3.9

—

(3028192) IgG subclass 2 [Mass/volume] in Serum

0.00

0.21

0.0

1.1

—

3.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

228

0.85

0.21

2.8

3.8

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.1

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.29

0.21

12.3

6.1

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.20

0.0

2.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

153

0.83

0.19

1.5

1.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

953

1.15

0.19

4.7

4.4

6.0

5.9

mmol/l

0.37

883

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

163

0.84

0.18

3.0

2.8

0.5

0.7

ug/l

—

108

(3009542) Hematocrit [Volume Fraction] of Blood

903

1.13

0.18

17.7

13.5

38.6

40.1

0.53

703

(3019060) Gas panel - Arterial blood

1.19

0.17

7.0

3.5

—

(3029937) Albumin [Presence] in Urine by Test strip

255

1.13

0.17

7.6

3.8

0.0

estimate

0.00

(3022621) pH of Urine by Test strip

1.14

0.16

3.6

3.1

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.12

0.16

4.9

3.1

9.0

10.1

g/l

—

(4035726)

0.74

0.16

1.7

1.5

—

(40758558) Short blood count panel - Blood

261

0.90

0.13

4.8

7.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

220

1.11

0.13

4.7

4.5

19.2

20.6

—

108

(40761511) CBC panel - Blood by Automated count

106

1042

1.14

0.12

17.3

11.6

—

(3022145) Colonoscopy Study observation

116

0.85

0.12

1.0

1.3

—

(21494755) Public health laboratory ask at order entry panel

126

0.86

0.12

1.5

1.3

—

(3002256) Pathology report gross observation

115

1.15

0.11

1.0

1.3

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.17

0.10

1.0

1.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.17

0.10

1.8

1.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.07

0.09

32.6

3.4

22.5

25.2

mmol/l

—

(40768804) Tissue Pathology biopsy report

392

1.07

0.09

2.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.10

0.09

1.7

3.4

—

(3027801) Oxygen [Partial pressure] in Arterial blood

113

0.87

0.08

7.9

4.2

10.7

12.1

kpa

—

107

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

113

0.87

0.08

7.9

4.2

4.8

5.0

kpa

—

106

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

934

1.08

0.08

13.0

11.4

85.6

83.3

ml/min/173m2

0.55

747

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.06

0.08

1.6

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

111

0.89

0.06

1.3

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

103

1.07

0.02

2.7

1.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

113

1.07

0.02

3.8

2.0

—

(3016502) Oxygen saturation in Arterial blood

104

0.96

0.00

8.0

4.6

96.3

96.1

—

(3003396) Base excess in Arterial blood by calculation

114

0.96

0.00

7.5

4.4

1.9

1.5

mmol/l

—

(3000494) Fungus identified in Specimen by Culture

124

0.96

0.00

2.1

1.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.02

0.00

4.2

1.9

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

102

0.98

0.00

6.1

8.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.88

0.00

1.2

1.5

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

0.93

0.00

8.8

4.6

126.8

123.8

g/l

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.4

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.0

—

(3000991) Gas panel - Venous blood

0.90

0.00

14.4

4.4

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.3

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.5

—

9.4

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.0

—

(4010399)

0.99

0.00

1.9

1.4

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.4

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

3.6

—

(40761535) Cells panel - Urine sediment

0.89

0.00

2.3

3.6

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(4146454)

0.00

0.0

2.7

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

120.7

—

(4027681)

0.00

0.0

1.1

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

7.8

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.3

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.2

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

8.8

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

6.9

—

0.6

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

2.7

—

4.5

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.95

0.00

1.9

1.7

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

14.4

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

(36660697) Celiac disease serology panel - Serum

0.94

0.00

1.1

1.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

200

1.00

0.00

2.8

1.8

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.4

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.3

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

41.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.00

0.00

3.0

1.6

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.8

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.91

0.00

1.4

1.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.95

0.00

1.5

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.91

0.00

2.0

1.9

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

5.9

—

145.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_FOREIGNBODYGRANULOMA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_FOREIGNBODYGRANULOMA.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_FOREIGNBODYGRANULOMA – Foreign body granuloma of skin and subcutaneous tissue

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Foreign body granuloma of skin and subcutaneous tissue

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints