Foreign body granuloma of skin and subcutaneous tissue

L12_FOREIGNBODYGRANULOMA

granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L92.3 Hospital discharge: ICD-9 — 7094 Cause of death: ICD-10 — L92.3 Cause of death: ICD-9 — 7094 2 out of 7 registries used, show all original rules.	128
4. Check minimum number of events None	128
5. Include endpoints None	128
6. Filter based on genotype QC (FinnGen only)	124

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L92
Name in latin: Granuloma cutis vel telae subcutaneae ex corpore alieno

NAME	L12_FOREIGNBODYGRANULOMA
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L923
HD_ICD_9	7094
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L923
COD_ICD_9	7094
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Foreign body granuloma of skin and subcutaneous tissue based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1088	532	551
Only index persons	970	472	498
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	42.35	44.17	40.60
Only index persons	42.59	44.60	40.67

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	124	73	51
Unadjusted period prevalence (%)	0.02	0.03	0.02
Median age at first event (years)	48.63	47.82	49.78

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
128: Matched controls
1280

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L92.3

ICD-10 Finland

Foreign body granuloma of skin and subcutaneous tissue

+∞

144.7

110

7094A

ICD-9 Finland

Other disorders of skin and subcutaneous tissue, Foreign body granuloma of skin and subcutaneous tissue

+∞

19.2

9736

FHL

Subcutaneous tumor removal in operating room or anesthesia

96.1

8.5

QCE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in upper limb

14.3

8.1

R31

ICD-10 Finland

Unspecified haematuria

4.4

6.4

UKC02

NOMESCO Finland

Cystoscopy

3.4

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

107

2.79

4.67

2.4

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

277

2.25

4.47

5.7

3.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

697

2.22

3.95

7.0

4.1

—

(3006504) Eosinophils/100 leukocytes in Blood

486

2.04

3.78

6.8

6.0

2.86

2.90

0.06

457

(3018010) Neutrophils/100 leukocytes in Blood

496

2.03

3.76

6.1

53.45

56.07

1.11

472

(3022096) Basophils/100 leukocytes in Blood

472

2.00

3.64

5.8

5.9

0.71

0.69

0.15

442

(3019069) Monocytes/100 leukocytes in Blood

492

2.00

3.59

7.9

6.3

8.27

8.40

0.14

465

(3002030) Lymphocytes/100 leukocytes in Blood

506

1.97

3.45

6.7

6.2

32.00

29.29

1.31

480

(3013115) Eosinophils [#/volume] in Blood

530

1.94

3.30

6.8

6.6

0.20

0.19

e9/l

0.09

477

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

142

2.24

3.21

1.6

1.7

—

(3019198) Lymphocytes [#/volume] in Blood

527

1.90

3.12

6.1

6.2

2.03

1.96

e9/l

0.19

476

(3000850) Epithelial cells [#/volume] in Urine

199

2.04

3.01

6.9

2.3

4.15

4.75

e6/l

0.22

181

(3006315) Basophils [#/volume] in Blood

513

1.86

2.98

6.1

6.2

0.04

e9/l

0.13

452

(3001604) Monocytes [#/volume] in Blood

513

1.86

2.98

6.0

6.2

0.60

0.56

e9/l

0.59

450

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

109

2.23

2.66

1.5

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

104

2.22

2.54

1.5

1.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.99

2.51

1.4

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

503

1.75

2.49

5.3

3.7

0.00

0.01

estimate

0.50

(3009261) Glucose [Presence] in Urine by Test strip

513

1.75

2.48

5.2

3.8

0.00

estimate

-0.00

(3022217) INR in Platelet poor plasma by Coagulation assay

441

1.73

2.40

24.0

11.2

1.28

1.23

inr

0.18

117

(3019150) Specific gravity of Urine by Refractometry

223

1.85

2.37

5.2

4.2

1.02

kg/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

502

1.70

2.28

7.3

5.1

0.00

estimate

-0.00

(3013707) Erythrocyte sedimentation rate by Westergren method

763

1.80

2.28

5.8

4.4

10.86

11.19

mm/h

0.09

704

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

392

1.71

2.24

5.9

3.7

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

3.04

2.12

2.2

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

2.64

2.07

1.5

1.7

—

(40768443) Skin Pathology biopsy report

2.77

2.05

1.0

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

356

1.66

2.00

5.7

3.0

—

(3027008) Opiates [Presence] in Urine

2.69

1.99

2.1

1.3

—

(3028300) Cannabinoids [Presence] in Urine

2.69

1.99

2.2

1.3

—

(3002582) Erythrocytes [#/volume] in Urine

312

1.68

1.99

6.5

3.0

13.14

252.22

e6/l

0.59

236

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

3.88

1.96

1.2

1.9

—

(3018095) Leukocytes [#/volume] in Urine

361

1.63

1.87

6.8

3.7

14.20

78.69

e6/l

1.88

251

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

773

1.68

1.84

4.3

3.9

14.25

14.72

pmol/l

1.06

714

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

2.22

1.84

1.2

1.3

—

28.25

—

(3016879) Cocaine [Presence] in Urine

2.61

1.78

2.2

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

478

1.58

1.74

8.0

6.6

—

(3042936) Bacteria identified in Isolate by Culture

136

1.84

1.73

1.9

1.8

—

(3027944) Amphetamines [Presence] in Urine

2.62

1.71

2.2

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

2.62

1.71

2.1

1.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.26

1.68

1.3

1.5

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.26

1.68

1.2

1.9

—

(3044290) Cell count panel - Cerebral spinal fluid

3.26

1.68

1.5

1.1

—

(4094501) Cardiovascular stress test using bicycle ergometer

2.90

1.67

1.3

1.2

—

(3013512) EKG study

289

1.62

1.67

4.2

3.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

220

1.67

1.66

1.7

1.51

1.10

mg/l

0.28

171

(40761536) Microorganisms panel - Urine sediment

2.09

1.61

8.3

3.6

—

(3026008) Bacteria identified in Urine by Culture

285

1.59

1.54

4.7

2.9

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

3.42

1.54

1.2

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

718

1.55

1.50

3.2

—

(3017181) Myelocytes/100 leukocytes in Blood

1.94

1.49

3.8

3.4

0.43

0.91

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

360

1.53

1.48

2.9

3.8

22.09

39.53

ng/l

0.70

243

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.58

1.47

1.7

2.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.58

1.47

2.0

3.5

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

3.21

1.45

1.0

1.1

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

610

1.51

1.45

6.7

10.6

3.87

3.91

e9/l

0.05

532

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.49

1.41

1.7

—

(3011288) Drugs identified in Urine by Screen method

2.49

1.41

2.3

1.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

467

1.49

1.39

11.9

6.6

1.22

mmol/l

0.08

406

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.57

1.32

1.2

1.8

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.57

1.32

1.2

1.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

387

1.43

1.12

2.0

1.8

101.75

98.18

pmol/l

0.26

188

(3049717) Cytology report of Urine Cyto stain

2.18

1.07

2.7

2.2

—

(3022313) Gas panel - Capillary blood

1.90

1.01

18.7

3.6

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.86

0.99

1.8

3.5

0.68

0.73

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.86

0.99

1.0

1.1

—

(3000330) Specific gravity of Urine by Test strip

1.86

0.99

2.3

2.9

—

(3044640) Blood type and Crossmatch panel - Blood

331

1.40

0.96

2.0

2.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.71

0.95

2.5

3.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.79

0.94

1.8

3.5

1.01

1.23

—

(36304419) Bacteria [Presence] in Urine

277

1.42

0.93

5.6

2.8

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

171

1.50

0.92

1.1

1.3

19.75

30.50

iu/ml

—

(3030467) Casts [#/volume] in Urine by Automated count

279

1.40

0.90

5.7

2.9

0.14

0.25

e6/l

0.51

205

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.76

0.85

1.0

—

(3019309) Folate [Moles/volume] in Red Blood Cells

174

1.47

0.85

1.4

1.6

1141.25

1196.15

nmol/l

0.10

133

(3002179) Metamyelocytes/100 leukocytes in Blood

1.69

0.81

4.0

3.3

0.60

0.73

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.78

0.0

1.6

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

142

1.48

0.78

8.7

4.0

0.79

0.81

mmol/l

0.33

134

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

112

1054

1.50

0.75

18.5

12.7

24.02

23.26

mg/l

0.08

826

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.89

0.75

1.3

1.1

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.04

0.73

25.6

2.5

21.76

23.77

mmol/l

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

2.04

0.73

1.0

1.1

—

1.10

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

794

1.30

0.66

7.7

7.6

77.71

77.19

u/l

0.04

748

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

157

1.40

0.64

2.0

1.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

294

1.31

0.64

4.1

3.6

3.85

8.04

mg/mmol

0.98

174

(3017143) Hepatitis C virus Ab [Presence] in Serum

115

1.45

0.60

2.5

1.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.60

0.0

1.6

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

169

1.36

0.58

2.3

2.8

1.18

0.94

e6/l

0.12

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

491

1.25

0.57

3.0

2.4

—

(40768797) Stomach Pathology biopsy report

143

1.39

0.56

1.3

1.2

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.65

0.56

8.8

4.1

0.92

1.57

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

161

1.36

0.56

2.4

3.0

1.42

3.20

e6/l

0.84

(3023368) Bacteria identified in Blood by Culture

246

1.29

0.52

4.2

4.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

173

1.33

0.51

1.1

1.3

19.06

9.95

u/ml

—

(3019225) pH of Specimen

1.44

0.50

3.6

4.5

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.52

0.48

2.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.49

0.46

1.8

1.4

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.42

0.44

1.5

2.2

13.17

13.55

nmol/l

0.06

(3009542) Hematocrit [Volume Fraction] of Blood

122

1185

1.63

0.44

23.9

18.8

39.38

40.28

0.52

115

1124

(3051387) C reactive protein [Mass/volume] in Capillary blood

1.64

0.43

2.6

4.9

32.80

28.55

mg/l

—

(3047181) Lactate [Moles/volume] in Blood

1.64

0.43

10.8

5.2

1.14

1.23

mmol/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

171

0.73

0.43

1.5

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.58

0.42

1.4

1.3

—

(3021589) Normoblasts [#/volume] in Blood

464

1.20

0.42

8.0

8.7

0.00

0.01

e9/l

0.52

367

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.54

0.42

2.0

1.6

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.41

0.0

1.5

—

15.40

—

(3000492) Spirometry study

106

1.36

0.41

1.3

1.4

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.44

0.40

6.6

5.7

24.37

24.48

mmol/l

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.40

0.0

1.8

—

0.71

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.45

0.40

1.0

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

236

1.24

0.39

1.4

1.6

—

(3007164) IgA [Mass/volume] in Serum or Plasma

236

1.24

0.39

1.6

1.4

2.32

2.15

g/l

0.22

130

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.39

0.0

2.7

—

51.66

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.37

0.39

2.4

1.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

109

1047

1.28

0.39

5.3

4.7

2.78

mmol/l

0.00

104

978

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

256

1.22

0.38

1.3

3.07

1.27

u/ml

0.44

(3044889) 12 lead EKG panel

698

1.18

0.37

3.5

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.49

0.36

1.8

1.5

7.42

26.21

iu/l

—

(3022948) Iron [Moles/volume] in Serum or Plasma

155

0.75

0.35

7.0

2.3

11.61

13.63

umol/l

0.90

141

(1761868) Lipid panel - Serum or Plasma

383

1.18

0.35

2.6

2.8

—

(3012516) Albumin [Mass/volume] in Urine

279

1.20

0.33

4.0

2.9

29.23

59.03

mg/l

0.83

166

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.29

0.32

12.3

6.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

251

1.20

0.32

2.2

2.0

—

(3018418) pH of Serum or Plasma

290

1.19

0.31

5.8

4.2

7.39

7.40

—

(3025941) Bacteria identified in Stool by Culture

1.25

0.27

1.5

1.2

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.25

0.27

1.6

3.4

4.67

4.66

pmol/l

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

115

1121

1.25

0.26

20.1

14.5

75.92

74.61

umol/l

0.20

115

1121

(3003694) ABO and Rh group [Type] in Blood

285

0.85

0.26

1.7

1.4

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.37

0.24

1.4

2.1

—

(3012544) pH of Venous blood

1.26

0.24

9.9

3.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

103

0.76

0.22

2.1

1.9

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

9.3

—

1009.64

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

15.6

—

1754.27

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

83.40

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.0

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

8.0

—

0.65

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.4

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.21

0.0

1.6

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.0

—

(3014037) CD3+CD4+ (T4 helper) cells/100 cells in Blood

0.00

0.21

0.0

2.0

—

51.20

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.1

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

4.2

—

4.12

—

(4062490) Immunoglobulin typing, IgG

0.00

0.20

0.0

1.1

—

(3024139) IgG subclass 3 [Mass/volume] in Serum

0.00

0.20

0.0

1.1

—

0.59

—

(3028192) IgG subclass 2 [Mass/volume] in Serum

0.00

0.20

0.0

1.1

—

3.09

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.20

0.0

2.9

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

164

0.84

0.19

3.0

2.8

0.50

0.71

ug/l

—

108

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

104

1012

1.15

0.19

4.7

4.3

5.98

5.88

mmol/l

0.36

941

(3008898) HLA-B27 [Presence]

1.16

0.19

1.0

1.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

121

0.81

0.19

1.3

1.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.20

0.18

1.6

3.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.14

0.17

1.3

1.2

—

(3019060) Gas panel - Arterial blood

1.19

0.17

7.0

3.5

—

(40761511) CBC panel - Blood by Automated count

113

1108

1.17

0.17

16.6

11.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.15

0.16

1.6

1.3

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.17

0.16

4.4

3.1

9.17

10.10

g/l

—

(4035726) Immunohistochemistry procedure

0.81

0.15

1.6

1.5

—

(3000991) Gas panel - Venous blood

0.77

0.15

14.4

5.0

—

(3029937) Albumin [Presence] in Urine by Test strip

267

1.11

0.14

7.4

3.8

0.00

estimate

-0.00

(3022145) Colonoscopy Study observation

128

0.85

0.14

1.0

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

221

1.11

0.12

4.8

4.4

19.25

20.58

—

108

(40768804) Tissue Pathology biopsy report

420

1.07

0.10

2.0

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.14

0.10

1.8

1.5

—

(3027801) Oxygen [Partial pressure] in Arterial blood

114

0.87

0.10

7.9

4.3

10.73

12.14

kpa

—

108

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

114

0.87

0.10

7.9

4.3

4.76

5.03

kpa

—

107

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.09

0.09

3.2

1.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.04

0.08

1.3

—

(3002256) Pathology report gross observation

127

1.11

0.08

1.0

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

245

0.93

0.08

2.7

3.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.84

0.08

1.5

1.4

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.85

0.08

1.2

1.5

—

(3022621) pH of Urine by Test strip

1.10

0.08

3.6

3.1

—

(21494755) Public health laboratory ask at order entry panel

132

0.90

0.07

1.5

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

208

0.95

0.02

2.8

1.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

100

992

1.04

0.02

12.9

11.3

85.52

83.45

ml/min/173m2

0.50

796

(3019832) Treponema pallidum Ab [Presence] in Serum

104

1.06

0.01

2.7

1.7

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

106

0.94

0.01

4.2

1.8

—

(3016502) Oxygen saturation in Arterial blood

104

0.96

0.00

8.0

4.6

96.30

96.16

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

109

1.01

0.00

6.0

8.3

—

(40758558) Short blood count panel - Blood

279

1.00

0.00

4.4

7.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

122

0.98

0.00

3.7

2.0

—

(3000494) Fungus identified in Specimen by Culture

128

1.02

0.00

2.0

1.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

122

0.98

0.00

2.2

5.3

102.58

103.79

mmol/l

0.21

122

(3003396) Base excess in Arterial blood by calculation

115

0.95

0.00

7.5

4.4

1.90

1.43

mmol/l

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

105

0.95

0.00

1.8

1.7

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.2

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

14.40

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.8

—

(3030313) Adrenal Ab [Titer] in Serum

0.00

0.0

1.0

—

(3035062) Alkaline phosphatase.liver 1 [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

88.60

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.92

0.00

32.6

5.0

22.54

25.25

mmol/l

—

(3036185) Alkaline phosphatase.liver 2 [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

34.60

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.1

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.3

—

(36660697) Celiac disease serology panel - Serum

0.99

-0.00

1.1

1.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.0

—

8.81

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(4200892) Spirometry reversibility

0.89

-0.00

1.9

1.5

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

41.27

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

7.8

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

1.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

5.3

—

132.25

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.3

—

(3045716) Anion gap in Serum or Plasma

0.00

-0.00

0.0

3.2

—

9.67

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40761535) Cells panel - Urine sediment

0.94

-0.00

2.1

3.5

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

3.64

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

2.3

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

120.67

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.96

-0.00

3.0

1.6

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

2.7

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.1

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

2.0

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.4

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.7

—

4.49

—

(3034426) Prothrombin time (PT)

0.00

-0.00

0.0

1.4

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.4

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.5

—

9.38

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_FOREIGNBODYGRANULOMA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_FOREIGNBODYGRANULOMA.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_FOREIGNBODYGRANULOMA – Foreign body granuloma of skin and subcutaneous tissue

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Foreign body granuloma of skin and subcutaneous tissue

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints