No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
154 |
4. Check minimum number of eventsNone |
154 |
5. Include endpointsNone |
154 |
6. Filter based on genotype QC (FinnGen only) |
154 |
Control definitions (FinnGen only)
- Control exclude
- O15_MATERN_CARE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF3
- Parent code in ICD-10
- O30-O48
- Name in latin
- Complicationes specificae plurifetationis
Similar endpoints
↥List of similar endpoints to
Complications specific to multiple gestation
based on the number of shared cases.
Similar with more cases:
- Maternal care related to the fetus and amniotic cavity and possible delivery problems
- Pregnancy, childbirth and the puerperium
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 989 | 989 | - |
| Only index persons | 980 | 980 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | - |
| Only index persons | 0.04 | 0.04 | - |
| Median age at first event (years) | |||
| Whole population | - | 31.40 | - |
| Only index persons | - | 31.40 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 154 | 154 | - |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | - |
| Median age at first event (years) | 31.92 | 31.92 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 143
- Matched controls
- 1430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O31.2
ICD-10 Finland
Continuing pregnancy after intrauterine death of one fetus or more
+∞
65.8
58
*
O30.0
ICD-10 Finland
Twin pregnancy
+∞
60.9
54
*
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
22.0
42.1
65
52
O31.8
ICD-10 Finland
Other complications specific to multiple gestation
+∞
38.3
35
*
O31.1
ICD-10 Finland
Continuing pregnancy after abortion of one fetus or more
+∞
37.1
34
*
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
24.0
29.9
43
25
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
13.5
29.9
56
65
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
+∞
29.2
27
*
O32.1
ICD-10 Finland
Maternal care for breech presentation
+∞
24.7
23
*
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
+∞
23.6
22
*
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
6.7
23.1
75
202
O60
ICD-10 Finland
Preterm labour and delivery
47.0
22.7
27
7
O35.8
ICD-10 Finland
Maternal care for other (suspected) fetal abnormality and damage
+∞
21.4
20
*
Z39.2
ICD-10 Finland
Routine postpartum follow-up
5.6
18.2
65
185
O42.9
ICD-10 Finland
Premature rupture of membranes, unspecified
+∞
18.1
17
*
O82.0
ICD-10 Finland
Delivery by elective caesarean section
33.9
18.1
23
8
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
4.9
16.5
70
235
O30.00
ICD-10 Finland
Twin pregnancy with separate amniotic and chorionic sacs
+∞
14.8
14
*
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
12.1
14.8
27
27
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
5.9
14.4
44
100
O35.1
ICD-10 Finland
Maternal care for (suspected) chromosomal abnormality in fetus
+∞
13.8
13
*
O30.01
ICD-10 Finland
Twin pregnancy with a shared chorionic sac and a separate amniotic sac
+∞
13.8
13
*
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
+∞
13.8
13
*
6460A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Papyraceous foetus
+∞
12.7
12
*
O31.0
ICD-10 Finland
Papyraceous fetus
+∞
12.7
12
*
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
3.6
11.9
82
391
O43.0
ICD-10 Finland
Placental transfusion syndromes
+∞
11.6
11
*
O42.0
ICD-10 Finland
Premature rupture of membranes, onset of labour within 24 hours
+∞
11.6
11
*
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
130.0
11.6
12
*
W78
ICPC
Pregnancy
3.7
11.2
63
252
SPAT1379
SPAT
Health check-up of pregnant person
4.2
11.1
48
153
O80.8
ICD-10 Finland
Other single spontaneous delivery
11.4
10.9
20
20
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
5.4
10.8
34
78
O30.1
ICD-10 Finland
Triplet pregnancy
+∞
10.5
10
*
O36.4
ICD-10 Finland
Maternal care for intrauterine death
+∞
10.5
10
*
G03GA01
ATC
chorionic gonadotrophin; parenteral
6.2
10.2
28
54
SPAT1380
SPAT
Postpartum check-up
4.0
9.8
43
138
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
3.8
9.7
46
158
MAJ00
NOMESCO Finland
Reduction of multiple pregnancy by one foetus
+∞
9.5
9
*
O41.0
ICD-10 Finland
Oligohydramnios
+∞
9.5
9
*
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
6.5
8.6
22
39
O46.9
ICD-10 Finland
Antepartum haemorrhage, unspecified
95.4
8.5
9
*
O48
ICD-10 Finland
Prolonged pregnancy
+∞
8.4
8
*
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
4.9
8.4
28
68
G03GA06
ATC
follitropin beta; parenteral
8.1
8.3
18
25
Z32.1
ICD-10 Finland
Pregnancy confirmed
3.7
8.2
39
132
O64.1
ICD-10 Finland
Obstructed labour due to breech presentation
35.6
8.2
10
*
SPAT1197
SPAT
Extensive health check-up of expecting family
3.2
8.2
50
205
MAA00
NOMESCO Finland
Amniocentesis
19.7
7.7
11
6
W84
ICPC
Pregnancy high risk
7.2
7.7
18
28
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
7.2
7.7
18
28
H01CC01
ATC
ganirelix; parenteral
5.8
7.6
21
41
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
3.3
7.4
41
156
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
7.3
7.4
17
26
O40
ICD-10 Finland
Polyhydramnios
+∞
7.3
7
*
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
5.4
7.2
21
44
XMA22
NOMESCO Finland
General examination of pregnant woman
4.9
6.9
22
51
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
2.8
6.3
46
205
MA4AT
NOMESCO Finland
Chorion biopsy with ultrasound guidance
+∞
6.3
6
*
O42.1
ICD-10 Finland
Premature rupture of membranes, onset of labour after 24 hours
+∞
6.3
6
*
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
+∞
6.3
6
*
O47.1
ICD-10 Finland
False labour at or after 37 completed weeks of gestation
+∞
6.3
6
*
O35.9
ICD-10 Finland
Maternal care for (suspected) fetal abnormality and damage, unspecified
+∞
6.3
6
*
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
6.6
6.2
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
35
145
2.83
6.18
1.8
2.1
4319.7
2016.6
u/l
0.28
15
54
21
75
3.08
4.77
2.5
3.5
236.4
249.5
u/l
0.20
21
75
36
174
2.40
4.59
1.5
1.4
—
—
—
0
0
26
108
2.69
4.52
1.5
1.3
—
—
—
0
0
18
67
2.91
3.81
1.6
1.3
—
—
—
0
0
8
14
5.96
3.38
1.3
1.2
—
—
—
0
0
8
15
5.56
3.23
1.9
1.4
—
—
—
0
0
48
319
1.73
2.43
3.3
2.9
0.0
0.0
estimate
0.50
27
112
15
66
2.41
2.33
2.0
1.5
—
—
—
0
0
77
593
1.60
2.15
4.7
3.6
—
—
—
0
0
13
56
2.44
2.11
1.5
1.3
—
—
—
0
0
132
1172
1.88
2.03
4.4
3.9
—
—
—
0
0
64
478
1.58
2.00
3.3
2.7
—
—
—
0
0
6
16
3.86
1.95
1.2
1.5
—
—
—
0
0
53
410
1.45
1.32
2.0
1.6
—
—
—
0
0
7
143
0.47
1.28
1.4
1.6
—
—
—
0
0
28
191
1.57
1.25
1.3
1.5
—
—
—
0
0
18
110
1.72
1.22
1.5
1.4
—
—
—
0
0
74
616
1.39
1.19
4.8
4.1
0.0
0.0
estimate
0.00
28
113
0
34
0.00
1.17
0.0
4.3
—
24.4
—
0
34
74
623
1.36
1.09
3.5
2.9
0.0
0.0
estimate
0.00
28
109
9
47
1.97
1.04
1.3
1.3
—
—
—
0
0
73
618
1.34
1.02
3.5
2.8
0.0
0.0
estimate
0.00
25
110
15
229
0.62
0.97
1.3
1.5
1.2
1.2
%
0.06
15
210
8
43
1.91
0.89
1.0
1.0
—
—
—
0
0
8
43
1.91
0.89
1.4
1.3
—
—
—
0
0
37
288
1.37
0.87
1.9
2.1
2.8
2.8
mg/l
0.04
30
250
8
45
1.82
0.85
1.6
2.4
—
—
—
0
0
37
295
1.33
0.75
2.0
2.8
15.5
16.3
ng/l
0.04
11
119
11
68
1.67
0.74
1.6
1.7
—
—
—
0
0
30
233
1.36
0.72
2.4
2.2
288.4
2982.7
umol/l
0.80
24
220
7
117
0.58
0.71
1.6
1.5
—
—
—
0
0
12
77
1.61
0.71
1.2
1.3
7.5
11.1
u/l
1.03
12
61
15
210
0.68
0.66
1.5
1.7
—
—
—
0
0
15
104
1.49
0.65
1.5
5.7
1.0
1.0
mmol/l
0.41
15
97
123
1294
0.75
0.65
9.9
10.4
38.7
39.8
%
0.93
103
1106
65
571
1.24
0.61
3.1
4.2
5.8
6.2
mmol/l
1.60
54
525
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
14
98
1.47
0.59
1.2
1.3
—
—
—
0
0
14
98
1.47
0.59
1.2
1.2
—
—
—
0
0
13
90
1.49
0.57
2.2
3.1
—
—
—
0
0
8
123
0.63
0.57
1.3
2.2
35.1
52.0
u/ml
—
8
117
14
99
1.46
0.56
1.2
1.3
—
—
—
0
0
14
99
1.46
0.56
1.2
1.3
—
—
—
0
0
9
59
1.56
0.56
1.1
3.0
5.6
5.8
kpa
—
9
59
21
264
0.76
0.50
1.6
1.8
—
—
—
0
0
22
174
1.31
0.48
1.4
1.2
227.0
170.6
iu/ml
0.31
11
75
7
48
1.48
0.47
2.6
1.4
—
—
—
0
0
45
391
1.21
0.46
1.6
1.8
92.7
95.5
pmol/l
0.19
30
235
5
31
1.63
0.43
1.0
2.0
1.4
1.3
%
—
5
31
5
33
1.53
0.41
1.4
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
131
1263
1.25
0.39
3.1
3.5
2.9
2.9
mmol/l
0.37
124
1213
123
1179
1.21
0.39
3.1
3.4
5.5
5.6
mmol/l
0.57
118
1118
18
143
1.29
0.39
1.6
2.4
7.7
152.6
ng/l
—
7
57
5
36
1.40
0.38
1.6
1.8
—
—
—
0
0
140
1363
1.30
0.35
7.5
8.0
23.8
23.8
u/l
0.01
135
1335
35
397
0.85
0.33
1.9
2.2
—
—
—
0
0
37
327
1.17
0.32
2.4
2.9
—
—
—
0
0
32
363
0.85
0.30
1.8
2.1
—
—
—
0
0
16
130
1.26
0.30
3.3
2.0
447.7
387.5
nmol/l
0.75
16
121
10
77
1.32
0.27
1.3
1.6
—
—
—
0
0
68
725
0.89
0.27
7.8
8.4
4.3
3.9
e9/l
0.80
63
639
16
134
1.22
0.24
1.3
1.7
—
—
—
0
0
5
39
1.29
0.23
1.6
8.5
22.0
24.8
mmol/l
—
5
39
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
10
80
1.27
0.21
1.3
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
2.6
—
406.0
—
0
7
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
128
1253
1.13
0.17
2.9
3.3
4.8
4.8
mmol/l
0.04
123
1213
49
463
1.09
0.14
1.5
1.4
—
—
—
0
0
78
757
1.06
0.10
2.9
3.0
75.1
56.3
ug/l
0.48
78
722
27
252
1.09
0.10
1.4
1.2
1.4
21.9
u/ml
1.84
14
100
28
262
1.08
0.10
2.6
2.0
—
—
—
0
0
25
267
0.92
0.09
1.3
1.3
10.7
20.1
iu/ml
—
7
89
6
54
1.12
0.09
1.2
1.5
—
—
—
0
0
5
61
0.81
0.08
1.2
1.5
7.0
24.5
u/l
—
5
49
5
61
0.81
0.08
2.0
1.3
—
—
—
0
0
11
123
0.89
0.08
2.9
3.9
4.2
4.7
pmol/l
0.87
11
110
7
66
1.06
0.08
1.6
2.1
—
—
—
0
0
9
84
1.08
0.07
1.4
1.4
—
—
—
0
0
46
448
1.04
0.04
4.8
6.4
1.2
1.2
mmol/l
0.03
35
384
27
260
1.05
0.03
3.6
1.9
144.7
152.8
u/l
0.05
27
246
94
950
0.97
0.03
2.3
2.7
31.5
32.0
u/l
0.03
89
918
41
402
1.03
0.02
3.3
5.6
1.2
1.2
mmol/l
0.23
35
377
118
1186
0.98
0.00
8.2
8.0
96.4
94.1
ml/min/173m2
0.80
104
930
11
109
1.01
0.00
1.3
1.4
—
—
—
0
0
36
356
1.01
0.00
1.4
1.2
1.2
1.6
u/ml
0.15
13
102
129
1289
1.00
0.00
10.4
9.5
13.4
18.0
mg/l
1.84
108
946
29
289
1.00
0.00
1.8
1.9
1.0
0.8
mg/l
0.30
21
204
10
98
1.02
0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
1.0
—
0
6
0
6
0.00
0.00
0.0
4.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
0.0
—
0
6
0
6
0.00
0.00
0.0
1.0
—
10.9
—
0
6
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.5
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
4.0
—
19.1
—
0
5
7
72
0.97
0.00
1.3
1.4
1.9
2.6
ug/l
—
7
65
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.1
—
0
5
0
7
0.00
0.00
0.0
1.1
—
1960.7
—
0
7
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint O15_MULTIP_GEST_COMPLIC and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have O15_MULTIP_GEST_COMPLIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: O15_MULTIP_GEST_COMPLIC – Complications specific to multiple gestation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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