No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleonly females |
293218 |
2. Check conditionsNone |
293218 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
158 |
4. Check minimum number of eventsNone |
158 |
5. Include endpointsNone |
158 |
6. Filter based on genotype QC (FinnGen only) |
148 |
Control definitions (FinnGen only)
- Control exclude
- O15_MATERN_CARE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF3
- Parent code in ICD-10
- O30-O48
- Name in latin
- Complicationes specificae plurifetationis
Similar endpoints
↥List of similar endpoints to
Complications specific to multiple gestation
based on the number of shared cases.
Similar with more cases:
- Maternal care related to the fetus and amniotic cavity and possible delivery problems
- Pregnancy, childbirth and the puerperium
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 989 | 989 | - |
| Only index persons | 980 | 980 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | - |
| Only index persons | 0.04 | 0.04 | - |
| Median age at first event (years) | |||
| Whole population | - | 31.40 | - |
| Only index persons | - | 31.40 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 148 | 148 | - |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | - |
| Median age at first event (years) | 31.79 | 31.79 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 158
- Matched controls
- 1580
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O31.2
ICD-10 Finland
Continuing pregnancy after intrauterine death of one fetus or more
+∞
73.9
65
*
O30.0
ICD-10 Finland
Twin pregnancy
+∞
67.7
60
*
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
16.0
64.0
70
75
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
21.3
54.2
45
29
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
12.8
51.8
64
80
O31.8
ICD-10 Finland
Other complications specific to multiple gestation
+∞
42.7
39
*
O31.1
ICD-10 Finland
Continuing pregnancy after abortion of one fetus or more
+∞
40.4
37
*
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
7.7
37.6
84
202
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
401.1
33.2
32
*
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
353.4
29.8
29
*
O32.1
ICD-10 Finland
Maternal care for breech presentation
+∞
27.9
26
*
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
7.2
26.7
49
93
Z39.2
ICD-10 Finland
Routine postpartum follow-up
5.6
25.8
75
218
O35.8
ICD-10 Finland
Maternal care for other (suspected) fetal abnormality and damage
+∞
24.6
23
*
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
5.3
24.2
79
251
O60
ICD-10 Finland
Preterm labour and delivery
33.2
23.3
30
11
O42.9
ICD-10 Finland
Premature rupture of membranes, unspecified
+∞
21.3
20
*
O82.0
ICD-10 Finland
Delivery by elective caesarean section
32.6
19.4
25
9
O30.00
ICD-10 Finland
Twin pregnancy with separate amniotic and chorionic sacs
+∞
19.1
18
*
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
7.3
17.9
29
47
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
4.2
17.6
93
404
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
+∞
17.0
16
*
G03GA01
ATC
chorionic gonadotrophin; parenteral
6.5
16.4
30
55
SPAT1379
SPAT
Health check-up of pregnant person
4.3
15.6
53
166
SPAT1380
SPAT
Postpartum check-up
4.5
15.3
47
136
W84
ICPC
Pregnancy high risk
7.7
15.3
23
34
W78
ICPC
Pregnancy
3.8
14.9
70
274
O35.1
ICD-10 Finland
Maternal care for (suspected) chromosomal abnormality in fetus
+∞
14.8
14
*
O43.0
ICD-10 Finland
Placental transfusion syndromes
+∞
13.7
13
*
O30.01
ICD-10 Finland
Twin pregnancy with a shared chorionic sac and a separate amniotic sac
+∞
13.7
13
*
O31.0
ICD-10 Finland
Papyraceous fetus
+∞
13.7
13
*
O42.0
ICD-10 Finland
Premature rupture of membranes, onset of labour within 24 hours
+∞
13.7
13
*
O80.8
ICD-10 Finland
Other single spontaneous delivery
7.1
13.7
22
35
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
152.6
13.7
14
*
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
3.8
12.8
51
176
Z32.1
ICD-10 Finland
Pregnancy confirmed
3.9
12.8
47
154
6460A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Papyraceous foetus
+∞
12.7
12
*
H01CC01
ATC
ganirelix; parenteral
6.2
12.0
22
40
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
5.7
11.9
24
48
MAA00
NOMESCO Finland
Amniocentesis
70.3
11.8
13
*
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
3.4
11.8
58
229
SPAT1197
SPAT
Extensive health check-up of expecting family
3.5
11.8
55
210
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
4.8
11.8
30
74
O46.9
ICD-10 Finland
Antepartum haemorrhage, unspecified
+∞
11.6
11
*
O41.0
ICD-10 Finland
Oligohydramnios
+∞
11.6
11
*
O30.1
ICD-10 Finland
Triplet pregnancy
+∞
11.6
11
*
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
4.1
11.6
37
109
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
3.6
11.2
46
161
O48
ICD-10 Finland
Prolonged pregnancy
+∞
10.5
10
*
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
4.6
10.0
26
65
ZXD05
NOMESCO Finland
Urgent procedure
3.0
9.9
66
307
O64.1
ICD-10 Finland
Obstructed labour due to breech presentation
58.7
9.8
11
*
O36.4
ICD-10 Finland
Maternal care for intrauterine death
+∞
9.5
9
*
MAJ00
NOMESCO Finland
Reduction of multiple pregnancy by one foetus
+∞
9.5
9
*
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
25.8
9.1
12
5
XMA22
NOMESCO Finland
General examination of pregnant woman
4.2
8.6
25
68
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
8.3
8.4
18
24
O40
ICD-10 Finland
Polyhydramnios
+∞
8.4
8
*
G03GA05
ATC
follitropin alfa; parenteral
5.0
8.4
19
42
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
3.3
8.4
37
134
O02.1
ICD-10 Finland
Missed abortion
4.0
8.1
25
71
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
6.4
7.5
19
33
OAA11, ,
SPAT
4.0
7.5
23
65
O47.1
ICD-10 Finland
False labour at or after 37 completed weeks of gestation
+∞
7.3
7
*
O35.9
ICD-10 Finland
Maternal care for (suspected) fetal abnormality and damage, unspecified
+∞
7.3
7
*
G03GA06
ATC
follitropin beta; parenteral
6.4
7.2
18
31
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.5
6.5
24
77
O42.1
ICD-10 Finland
Premature rupture of membranes, onset of labour after 24 hours
+∞
6.3
6
*
O36.8
ICD-10 Finland
Maternal care for other specified fetal problems
+∞
6.3
6
*
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
+∞
6.3
6
*
OAA12, ,
SPAT
4.3
6.1
16
40
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
39
154
3.03
7.58
1.5
1.4
—
—
—
0
0
38
152
2.98
7.20
2.0
2.0
3793.02
1364.60
u/l
0.38
18
54
20
64
3.43
5.41
1.6
1.2
—
—
—
0
0
21
73
3.16
4.99
2.5
3.4
236.43
246.63
u/l
0.14
21
73
18
63
3.10
4.22
2.1
1.5
—
—
—
0
0
15
51
3.14
3.68
1.5
1.3
—
—
—
0
0
8
14
5.95
3.38
1.9
1.3
—
—
—
0
0
8
15
5.55
3.23
1.3
1.2
—
—
—
0
0
51
326
1.83
2.99
3.4
2.8
0.00
0.01
estimate
0.50
29
114
7
13
5.58
2.90
1.9
1.4
6.43
8.02
mmol/l
—
7
13
80
590
1.72
2.84
2.8
2.2
—
—
—
0
0
67
492
1.63
2.29
3.4
2.6
—
—
—
0
0
6
16
3.85
1.95
1.2
1.5
—
—
—
0
0
18
93
2.06
1.94
1.5
1.4
—
—
—
0
0
78
625
1.49
1.68
4.8
4.0
0.00
0.00
estimate
-0.00
30
115
134
1208
1.72
1.65
4.4
3.8
—
—
—
0
0
78
632
1.46
1.55
3.5
2.8
0.00
0.00
estimate
-0.00
30
111
33
223
1.61
1.53
2.9
3.9
8.44
14.33
mg/mmol
0.35
25
128
5
122
0.39
1.44
1.8
4.3
—
—
—
0
0
77
629
1.44
1.44
3.6
2.8
0.00
0.00
estimate
-0.00
29
118
45
331
1.50
1.44
5.8
8.2
1.10
1.07
inr
0.16
20
113
55
429
1.43
1.30
2.0
1.5
—
—
—
0
0
7
145
0.46
1.28
1.4
1.6
—
—
—
0
0
28
192
1.56
1.22
1.3
1.5
—
—
—
0
0
0
34
0.00
1.17
0.0
4.3
—
24.38
—
0
34
69
573
1.36
1.10
3.1
4.1
5.78
6.18
mmol/l
1.89
58
531
9
48
1.93
1.02
1.3
1.3
—
—
—
0
0
15
230
0.62
0.98
1.3
1.5
1.23
1.26
%
0.08
15
211
14
85
1.71
0.98
1.2
1.3
—
—
—
0
0
14
85
1.71
0.98
1.2
1.3
—
—
—
0
0
38
292
1.40
0.96
1.9
2.1
2.82
2.70
mg/l
0.20
31
250
14
86
1.69
0.94
1.2
1.3
—
—
—
0
0
14
86
1.69
0.94
1.2
1.3
—
—
—
0
0
8
43
1.91
0.89
1.4
1.3
—
—
—
0
0
8
44
1.86
0.87
1.5
2.3
—
—
—
0
0
8
44
1.86
0.87
1.0
1.0
—
—
—
0
0
6
31
1.97
0.85
1.2
2.7
24.98
25.63
mmol/l
—
6
31
16
106
1.57
0.82
1.6
5.9
0.97
1.01
mmol/l
0.29
16
98
6
32
1.91
0.82
1.0
2.0
1.45
1.32
%
—
6
32
7
121
0.56
0.82
1.6
1.5
—
—
—
0
0
10
60
1.71
0.74
1.1
3.0
5.67
5.74
kpa
—
10
60
24
179
1.40
0.72
1.4
1.2
227.00
172.90
iu/ml
0.30
11
74
37
299
1.31
0.68
2.0
2.7
15.55
16.31
ng/l
0.04
11
120
11
70
1.61
0.67
1.6
1.7
—
—
—
0
0
5
30
1.69
0.62
1.2
2.7
54.46
52.58
%
—
5
30
8
52
1.57
0.60
2.4
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
12
82
1.50
0.56
1.2
1.3
7.55
10.84
u/l
1.01
12
67
13
91
1.47
0.55
2.2
3.1
—
—
—
0
0
46
394
1.24
0.54
1.6
1.8
93.87
95.72
pmol/l
0.12
31
234
19
145
1.35
0.52
1.5
2.4
7.71
152.53
ng/l
—
7
57
17
219
0.75
0.47
1.7
1.7
—
—
—
0
0
8
120
0.65
0.47
1.3
2.2
35.13
52.84
u/ml
—
8
114
53
471
1.19
0.42
1.5
1.4
—
—
—
0
0
5
33
1.53
0.41
1.4
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
5
34
1.49
0.40
1.8
1.9
13.40
12.94
%
—
5
34
126
1207
1.22
0.40
3.0
3.4
5.49
5.59
mmol/l
0.73
121
1145
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
134
1293
1.24
0.39
3.0
3.5
2.92
2.88
mmol/l
0.26
127
1246
23
275
0.81
0.37
1.8
1.8
—
—
—
0
0
38
333
1.19
0.35
2.5
3.0
—
—
—
0
0
69
745
0.87
0.35
8.1
8.5
4.31
3.87
e9/l
0.75
64
658
16
132
1.24
0.27
1.3
1.7
—
—
—
0
0
11
86
1.30
0.27
2.8
9.0
104.09
104.79
mmol/l
0.22
11
86
10
77
1.32
0.27
1.3
1.6
—
—
—
0
0
16
133
1.23
0.25
3.3
2.0
447.69
396.48
nmol/l
0.60
16
124
5
37
1.36
0.24
1.6
1.8
—
—
—
0
0
5
39
1.29
0.23
1.6
9.0
22.04
24.54
mmol/l
—
5
39
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
10
80
1.27
0.21
1.3
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
142
1394
1.18
0.20
7.7
7.9
23.63
23.66
u/l
0.01
137
1367
0
14
0.00
0.20
0.0
2.4
—
355.47
—
0
8
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
38
412
0.90
0.19
1.9
2.2
—
—
—
0
0
28
253
1.13
0.18
1.4
1.2
1.36
21.93
u/ml
1.84
14
100
28
254
1.12
0.17
2.6
2.0
—
—
—
0
0
8
68
1.19
0.17
1.3
1.4
2.15
2.59
ug/l
—
8
60
119
1216
0.91
0.15
8.3
8.0
96.46
94.36
ml/min/173m2
0.69
105
954
35
376
0.91
0.15
1.9
2.0
—
—
—
0
0
131
1286
1.11
0.14
2.9
3.3
4.81
4.80
mmol/l
0.04
126
1245
80
771
1.08
0.14
3.0
2.9
73.77
56.18
ug/l
0.45
80
734
10
86
1.17
0.11
1.4
1.3
—
—
—
0
0
6
55
1.09
0.09
1.2
1.4
—
—
—
0
0
5
61
0.81
0.08
1.2
1.5
6.96
24.52
u/l
—
5
49
125
1234
1.06
0.07
2.5
3.0
1.21
1.17
mmol/l
0.31
120
1180
43
416
1.05
0.05
3.2
5.5
1.21
1.22
mmol/l
0.18
36
389
48
466
1.04
0.05
4.7
6.2
1.22
1.21
mmol/l
0.06
37
398
38
367
1.05
0.05
1.4
1.3
1.20
1.60
u/ml
0.20
14
100
11
101
1.10
0.04
1.1
1.0
—
—
—
0
0
26
268
0.96
0.02
1.3
1.3
10.25
19.96
iu/ml
—
8
96
97
977
0.98
0.01
2.3
2.7
30.73
31.88
u/l
0.09
92
944
27
264
1.03
0.00
3.6
1.9
144.67
392.56
u/l
0.50
27
250
11
114
0.96
0.00
1.3
1.4
—
—
—
0
0
132
1315
1.02
0.00
10.3
9.4
13.24
18.06
mg/l
2.07
111
967
12
125
0.96
0.00
5.5
3.8
4.29
4.64
pmol/l
0.77
12
111
29
292
0.99
0.00
1.8
1.8
0.98
0.69
mg/l
0.45
21
208
0
5
0.00
-0.00
0.0
1.0
—
0.06
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.00
—
0
6
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
1960.71
—
0
7
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.33
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
10.87
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
1.02
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
71
0.99
-0.00
1.6
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.87
-0.00
2.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
19.14
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint O15_MULTIP_GEST_COMPLIC and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have O15_MULTIP_GEST_COMPLIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: O15_MULTIP_GEST_COMPLIC – Complications specific to multiple gestation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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