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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Traumatic amputation of lower leg

ST19_TRAUMAT_AMPUT_LOWER_LEG

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 S88
  • Cause of death: ICD-10 S88

2 out of 7 registries used, show all original rules.

75

4. Check minimum number of events

None

75

5. Include endpoints

None

75

6. Filter based on genotype QC (FinnGen only)

75

Control definitions (FinnGen only)

Control exclude
ST19_INJURI_KNEE_LOWER_LEG

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
S8
Name in latin
Amputatio traumatica genus sive cruris

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 75 14 61
Unadjusted period prevalence (%) 0.02 0.00 0.03
Median age at first event (years) 52.63 51.84 52.81

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
69
Matched controls
688
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
S88.1
ICD-10 Finland
Traumatic amputation at level between knee and ankle
+∞
59.1
48
*
NGQ20
NOMESCO Finland
Amputation of lower leg
+∞
36.8
32
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
101.9
24.9
26
*
NGQ48
NOMESCO Finland
Revision of exarticulation or amputation stump of knee or lower leg
+∞
22.0
20
*
X59
ICD-10 Finland
Exposure to unspecified factor
14.3
20.1
39
57
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
23.7
18.1
26
17
ZZA00
NOMESCO Finland
Split skin graft
36.6
15.3
19
7
ZXD05
NOMESCO Finland
Urgent procedure
8.5
15.1
44
118
S88.0
ICD-10 Finland
Traumatic amputation at knee level
+∞
14.0
13
*
S88.9
ICD-10 Finland
Traumatic amputation of lower leg, level unspecified
+∞
12.9
12
*
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
78.7
12.1
13
*
Z89.5
ICD-10 Finland
Acquired absence of leg at or below knee
+∞
11.8
11
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
9.7
11.6
25
38
NHQ40
NOMESCO Finland
Amputation of toe
24.6
10.3
14
7
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
17.0
9.7
15
11
NFQ20
NOMESCO Finland
Amputation of femur
115.2
9.7
10
*
T87.4
ICD-10 Finland
Infection of amputation stump
+∞
9.6
9
*
N03AX16
ATC
pregabalin; oral
5.7
9.5
33
96
J01FF01
ATC
clindamycin; systemic
5.4
9.5
36
116
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
10.2
9.1
18
23
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.8
8.8
28
72
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
6.7
8.8
24
51
T93.6
ICD-10 Finland
Sequelae of crushing injury and traumatic amputation of lower limb
+∞
8.5
8
*
AA1AD
NOMESCO Finland
CT of head and brain
5.1
8.1
29
85
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
9.6
7.9
16
21
A46
ICD-10 Finland
Erysipelas
5.6
7.9
25
63
L89
ICD-10 Finland
Decubitus ulcer and pressure area
51.0
7.9
9
*
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
89.3
7.6
8
*
S87.8
ICD-10 Finland
Crushing injury of other and unspecified parts of lower leg
+∞
7.4
7
*
SPAT1229
SPAT
Assessment of need for aid
7.7
7.4
17
28
ZXA05
NOMESCO Finland
Left side
4.5
7.3
30
100
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
16.0
7.2
11
8
ZXE20
NOMESCO Finland
More than three and less than five hours
5.6
6.9
21
50
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
8.5
6.6
14
20
ZX198
NOMESCO Finland
Other local administration
76.6
6.5
7
*
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
76.6
6.5
7
*
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
76.6
6.5
7
*
NG4AA
NOMESCO Finland
Lower leg X-ray examination
20.4
6.4
9
5
H3603, E103
ICD-10 Finland
NA
29.7
6.4
8
*
S82.8
ICD-10 Finland
Fractures of other parts of lower leg
+∞
6.3
6
*
NGU20
NOMESCO Finland
Removal of internal fixation device from knee or lower leg
+∞
6.3
6
*
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
+∞
6.3
6
*
G54.6
ICD-10 Finland
Phantom limb syndrome with pain
+∞
6.3
6
*

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ST19_TRAUMAT_AMPUT_LOWER_LEG – Traumatic amputation of lower leg

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).