Traumatic amputation of lower leg

ST19_TRAUMAT_AMPUT_LOWER_LEG

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — S88 Cause of death: ICD-10 — S88 2 out of 7 registries used, show all original rules.	75
4. Check minimum number of events None	75
5. Include endpoints None	75
6. Filter based on genotype QC (FinnGen only)	75

Control definitions (FinnGen only)

Control exclude: ST19_INJURI_KNEE_LOWER_LEG

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: S8
Name in latin: Amputatio traumatica genus sive cruris

NAME	ST19_TRAUMAT_AMPUT_LOWER_LEG
CONTROL_EXCLUDE	ST19_INJURI_KNEE_LOWER_LEG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	S88
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	S88
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Traumatic amputation of lower leg based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	75	14	61
Unadjusted period prevalence (%)	0.02	0.00	0.03
Median age at first event (years)	52.63	51.84	52.81

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
69: Matched controls
688

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

S88.1

ICD-10 Finland

Traumatic amputation at level between knee and ankle

+∞

59.1

NGQ20

NOMESCO Finland

Amputation of lower leg

+∞

36.8

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

101.9

24.9

NGQ48

NOMESCO Finland

Revision of exarticulation or amputation stump of knee or lower leg

+∞

22.0

X59

ICD-10 Finland

Exposure to unspecified factor

14.3

20.1

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

23.7

18.1

ZZA00

NOMESCO Finland

Split skin graft

36.6

15.3

S88.0

ICD-10 Finland

Traumatic amputation at knee level

+∞

14.0

S88.9

ICD-10 Finland

Traumatic amputation of lower leg, level unspecified

+∞

12.9

QDG20

NOMESCO Finland

Operation for chronic ulcer or fistula of skin of lower limb

78.7

12.1

Z89.5

ICD-10 Finland

Acquired absence of leg at or below knee

+∞

11.8

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

9.7

11.6

NHQ40

NOMESCO Finland

Amputation of toe

24.6

10.3

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

17.0

9.7

NFQ20

NOMESCO Finland

Amputation of femur

115.2

9.7

T87.4

ICD-10 Finland

Infection of amputation stump

+∞

9.6

N03AX16

ATC

pregabalin; oral

5.7

9.5

J01FF01

ATC

clindamycin; systemic

5.4

9.5

116

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

10.2

9.1

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

5.8

8.8

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

6.7

8.8

T93.6

ICD-10 Finland

Sequelae of crushing injury and traumatic amputation of lower limb

+∞

8.5

AA1AD

NOMESCO Finland

CT of head and brain

5.1

8.1

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

9.6

7.9

A46

ICD-10 Finland

Erysipelas

5.6

7.9

L89

ICD-10 Finland

Decubitus ulcer and pressure area

51.0

7.9

NHQ30

NOMESCO Finland

Amputation of foot, transmetatarsal

89.3

7.6

S87.8

ICD-10 Finland

Crushing injury of other and unspecified parts of lower leg

+∞

7.4

SPAT1229

SPAT

Assessment of need for aid

7.7

7.4

ZXA05

NOMESCO Finland

Left side

4.5

7.3

100

E11.5

ICD-10 Finland

Type 2 diabetes mellitus, with peripheral circulatory complications

16.0

7.2

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

8.5

6.6

ZX198

NOMESCO Finland

Other local administration

76.6

6.5

NHU20

NOMESCO Finland

Removal of internal fixation device from ankle or foot

76.6

6.5

E10.5

ICD-10 Finland

Type 1 diabetes mellitus, With peripheral circulatory complications

76.6

6.5

NG4AA

NOMESCO Finland

Lower leg X-ray examination

20.4

6.4

H3603, E103

ICD-10 Finland

29.7

6.4

S82.8

ICD-10 Finland

Fractures of other parts of lower leg

+∞

6.3

G54.6

ICD-10 Finland

Phantom limb syndrome with pain

+∞

6.3

M86.9

ICD-10 Finland

Osteomyelitis, unspecified

+∞

6.3

NGU20

NOMESCO Finland

Removal of internal fixation device from knee or lower leg

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3042936) Bacteria identified in Isolate by Culture

5.44

11.27

4.0

1.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

4.86

8.75

3.4

1.8

—

(3023368) Bacteria identified in Blood by Culture

177

2.83

4.61

6.0

4.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

101

3.02

4.38

2.0

1.8

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

12.87

3.83

1.2

1.6

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

5.86

3.63

1.7

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.89

3.24

2.2

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

256

2.33

3.18

7.2

4.1

—

(3000494) Fungus identified in Specimen by Culture

2.91

3.12

2.1

1.5

—

(3006504) Eosinophils/100 leukocytes in Blood

269

2.28

3.02

8.2

6.1

2.8

0.03

254

(3018010) Neutrophils/100 leukocytes in Blood

271

2.25

2.95

8.2

6.1

60.2

58.6

0.37

259

(3019069) Monocytes/100 leukocytes in Blood

271

2.25

2.95

8.8

6.4

8.0

8.6

0.62

260

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.72

2.91

2.2

1.6

—

(3044640) Blood type and Crossmatch panel - Blood

179

2.25

2.82

2.8

2.4

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

257

2.19

2.79

10.2

6.3

1.2

mmol/l

0.05

234

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.52

2.74

2.5

1.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.94

2.70

2.3

1.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

276

2.07

2.44

18.9

8.2

1.2

mmol/l

0.40

242

(3002030) Lymphocytes/100 leukocytes in Blood

276

2.07

2.44

9.0

6.3

23.7

25.9

0.60

265

(3026008) Bacteria identified in Urine by Culture

117

2.25

2.38

3.4

3.5

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

4.91

2.32

1.0

1.1

—

(3019150) Specific gravity of Urine by Refractometry

127

2.17

2.27

4.9

3.5

1.0

kg/l

—

(3028707) Methadone [Presence] in Urine by Screen method

5.86

2.25

4.2

1.6

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

614

0.47

2.22

5.4

4.6

1.3

mmol/l

0.83

555

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.50

2.17

5.4

3.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

588

0.49

2.14

24.2

13.5

84.3

81.3

ml/min/173m2

0.31

486

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

131

2.09

2.08

2.3

2.6

—

(3000570) Elastase.pancreatic [Mass/mass] in Stool

4.78

1.97

1.4

1.8

294.0

207.7

ug/g

—

(3013115) Eosinophils [#/volume] in Blood

310

1.91

1.97

11.9

6.4

0.2

e9/l

0.32

276

(3025941) Bacteria identified in Stool by Culture

3.07

1.92

1.0

1.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

382

1.93

1.88

5.3

4.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.53

1.78

1.3

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

180

1.89

1.78

8.5

3.7

2.3

mmol/l

0.71

162

(3019198) Lymphocytes [#/volume] in Blood

307

1.84

1.78

9.4

6.2

1.8

e9/l

0.00

274

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.19

1.74

2.3

1.5

—

(3006315) Basophils [#/volume] in Blood

300

1.81

1.71

9.4

6.1

0.0

e9/l

0.11

265

(1761868) Lipid panel - Serum or Plasma

243

0.48

1.69

3.1

3.0

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

600

0.53

1.65

4.4

4.2

1.6

1.4

mmol/l

1.19

539

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.59

1.59

1.9

1.5

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

613

0.54

1.52

5.1

4.7

4.6

4.5

mmol/l

0.24

557

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.04

1.49

2.1

1.4

—

(3011288) Drugs identified in Urine by Screen method

3.27

1.46

5.8

1.4

—

(3032080) INR in Blood by Coagulation assay

244

1.72

1.46

16.6

6.9

1.2

1.3

inr

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

3.07

1.38

1.0

1.2

—

(42870588) Differential panel, method unspecified - Blood

196

1.68

1.28

8.1

5.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

623

0.56

1.28

5.5

5.3

2.8

2.7

mmol/l

0.11

568

(3002582) Erythrocytes [#/volume] in Urine

179

1.69

1.26

3.4

3.0

25.8

367.6

e6/l

0.50

145

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

215

1.66

1.26

3.1

3.0

—

(3001604) Monocytes [#/volume] in Blood

299

1.63

1.25

9.8

6.1

0.7

0.6

e9/l

1.71

264

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.19

0.0

1.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.60

1.17

1.4

2.6

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.60

1.17

4.2

1.2

—

(3019309) Folate [Moles/volume] in Red Blood Cells

114

1.76

1.16

1.8

1.5

1111.6

1265.4

nmol/l

0.40

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.47

1.16

14.1

6.3

—

(3018095) Leukocytes [#/volume] in Urine

202

1.62

1.12

3.6

3.4

15.8

24.5

e6/l

0.48

156

(36304419) Bacteria [Presence] in Urine

158

1.66

1.11

3.0

2.8

—

(3027008) Opiates [Presence] in Urine

2.36

1.05

4.4

1.3

—

(3028300) Cannabinoids [Presence] in Urine

2.36

1.05

4.6

1.3

—

(3027944) Amphetamines [Presence] in Urine

2.36

1.05

4.4

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

2.36

1.05

4.4

1.3

—

(3016879) Cocaine [Presence] in Urine

2.36

1.05

4.2

1.2

—

(3012544) pH of Venous blood

1.94

0.97

12.3

4.4

—

(3026782) Osmolality of Urine

121

1.64

0.94

3.4

3.0

545.0

572.5

mosm/kgh2o

0.23

106

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

591

1.75

0.84

38.0

15.0

29.9

23.3

mg/l

1.03

482

(3035350) Ketones [Presence] in Urine by Test strip

281

1.46

0.82

4.7

3.5

0.0

estimate

—

(3015736) pH of Urine

216

1.47

0.80

5.1

3.2

—

(3048689) Calprotectin [Mass/mass] in Stool

1.76

0.78

2.1

2.4

277.0

140.9

ug/g

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

118

1.57

0.78

1.4

1.9

0.9

1.6

mg/l

1.07

101

(40758558) Short blood count panel - Blood

154

1.51

0.76

12.6

7.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.93

0.76

1.7

1.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.78

0.72

15.9

2.9

114.9

128.9

g/l

—

(3009261) Glucose [Presence] in Urine by Test strip

287

1.41

0.71

4.9

3.5

0.0

estimate

—

(3022621) pH of Urine by Test strip

1.72

0.58

2.7

2.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.63

0.56

1.0

3.1

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

1.49

0.50

6.8

2.2

20.7

24.0

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.59

0.49

3.6

2.2

7.2

14.4

nmol/l

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

591

0.74

0.46

6.1

4.8

6.7

6.1

mmol/l

1.24

542

(3021601) Nitrite [Presence] in Urine by Test strip

283

1.30

0.46

7.1

4.7

0.0

estimate

—

(40768804) Tissue Pathology biopsy report

213

0.74

0.45

4.6

2.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.48

0.44

1.0

1.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.66

0.44

6.8

3.8

43.8

50.5

—

(3019060) Gas panel - Arterial blood

1.45

0.44

7.6

3.3

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

424

1.29

0.43

5.3

3.4

102.0

54.3

u/l

1.02

397

(3020682) Albumin/Creatinine [Ratio] in Urine

208

1.30

0.43

4.0

4.2

79.3

10.7

mg/mmol

0.88

133

(36660697) Celiac disease serology panel - Serum

1.50

0.41

1.2

1.3

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.40

0.0

1.7

—

5.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

332

0.79

0.38

2.7

2.6

—

(40768797) Stomach Pathology biopsy report

0.63

0.38

1.8

1.3

—

(3002385) Erythrocyte distribution width [Ratio]

500

0.79

0.37

51.8

17.8

14.4

13.7

1.78

488

(3012516) Albumin [Mass/volume] in Urine

193

1.28

0.37

3.7

3.6

394.6

75.5

mg/l

1.04

130

(4035726)

1.41

0.32

2.1

1.5

—

(3019225) pH of Specimen

1.35

0.32

2.6

5.3

—

(3002256) Pathology report gross observation

1.28

0.28

2.9

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

541

0.82

0.27

44.1

14.9

38.3

40.8

0.73

391

(3029937) Albumin [Presence] in Urine by Test strip

162

1.23

0.26

5.2

3.4

0.0

estimate

—

(3009508) Creatinine [Moles/volume] in Urine

210

1.21

0.26

4.2

3.2

7.3

8.6

mmol/l

0.62

171

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.30

0.23

3.4

1.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

222

1.19

0.23

1.9

88.9

91.9

pmol/l

0.21

114

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.7

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.4

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

4.1

—

3.2

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.21

0.0

2.1

—

65.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

283

1.16

0.20

3.5

3.8

23.7

22.7

0.14

132

(3044889) 12 lead EKG panel

424

1.15

0.19

3.9

4.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

229

1.14

0.15

6.0

3.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

162

1.15

0.13

5.2

3.1

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

411

1.11

0.12

2.9

3.3

14.6

15.0

pmol/l

0.46

371

(3011397) Hemoglobin [Presence] in Urine by Test strip

127

1.13

0.08

4.9

3.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.07

0.08

1.4

—

(3013512) EKG study

171

0.92

0.05

5.6

4.4

—

(40761511) CBC panel - Blood by Automated count

640

1.12

0.05

31.0

13.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

578

0.94

0.02

8.7

6.2

45.8

40.8

mmol/mol

1.82

541

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

107

0.92

0.02

1.3

—

0.8

—

(3003694) ABO and Rh group [Type] in Blood

144

1.05

0.00

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

138

1.02

0.00

9.5

5.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

651

0.99

0.00

33.6

17.2

102.2

83.7

umol/l

0.70

651

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

2.1

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

9.8

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.1

—

9.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.3

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

9.9

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.4

—

(3025577) Chromium [Mass/volume] in Blood

0.00

0.0

1.6

—

1.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

3.6

—

57.9

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

3.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

3.5

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.3

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

1.6

—

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.7

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

3.6

—

4.8

—

(4027681)

0.00

0.0

1.3

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

5.8

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.3

—

13.1

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

3.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

3.0

—

(3021589) Normoblasts [#/volume] in Blood

280

1.00

0.00

14.8

10.0

0.0

e9/l

0.50

232

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.7

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.7

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.1

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.9

—

13.8

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

3.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.99

0.00

10.0

9.6

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.0

—

(4062490)

0.00

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3000991) Gas panel - Venous blood

0.96

0.00

6.2

7.7

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: ST19_TRAUMAT_AMPUT_LOWER_LEG – Traumatic amputation of lower leg

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Traumatic amputation of lower leg

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Traumatic amputation of lower leg (ST19_TRAUMAT_AMPUT_LOWER_LEG)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints