Phantom limb syndrome with pain

PHANTOMLIMB

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G54.6
  • Hospital discharge: ICD-9 3536
  • Cause of death: ICD-10 G54.6
  • Cause of death: ICD-9 3536

2 out of 7 registries used, show all original rules.

97

4. Check minimum number of events

None

97

5. Include endpoints

None

97

6. Filter based on genotype QC (FinnGen only)

96

Control definitions (FinnGen only)

Control exclude
PAIN

Extra metadata

First used in FinnGen datafreeze
DF3
Parent code in ICD-10
G54
Name in latin
Syndroma phantomatis membri dolorosum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 707 296 401
Only index persons 573 236 337
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 55.87 56.33 55.27
Only index persons 53.44 53.66 53.29

-FinnGen-

Key figures

All Female Male
Number of individuals 96 44 52
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 55.59 50.47 59.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
97
Matched controls
970
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G54.6
ICD-10 Finland
Phantom limb syndrome with pain
+∞
134.1
95
*
N03AX16
ATC
[U] pregabalin
27.0
63.2
67
74
N03AX12
ATC
[U] gabapentin; oral
19.6
48.6
50
50
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
20.0
40.7
37
29
N02AA05
ATC
oxycodone; systemic
13.1
36.7
50
73
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
11.7
30.1
40
55
N02AX02
ATC
tramadol; systemic, rectal
9.1
25.8
68
198
N06AX21
ATC
duloxetine; oral
13.2
25.4
28
29
L28
ICPC
Limited function/disability (L)
9.3
25.0
40
68
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
11.7
24.1
29
34
NGQ20
NOMESCO Finland
Amputation of lower leg
78.6
22.0
24
*
M79.6
ICD-10 Finland
Pain in limb
6.6
19.7
57
172
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
31.3
18.4
24
10
NFQ20
NOMESCO Finland
Amputation of femur
+∞
18.3
17
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
9.0
17.5
25
36
J01MA02
ATC
ciprofloxacin; systemic
6.0
17.3
61
214
N06AX16
ATC
venlafaxine; oral
7.6
16.5
28
49
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
8.5
16.1
24
36
TPH07
NOMESCO Finland
Cathetrisation of artery
7.7
15.2
25
42
NHQ40
NOMESCO Finland
Amputation of toe
36.3
14.5
18
6
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
29.0
14.4
19
8
N06AA09
ATC
amitriptyline; systemic
13.6
14.3
25
24
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
161.7
13.8
14
*
R52.2
ICD-10 Finland
Other chronic pain
161.7
13.8
14
*
N03AE01
ATC
clonazepam; systemic
20.6
13.7
20
12
TPH04
NOMESCO Finland
Cathetrisation of vein
5.5
13.5
35
91
J01FF01
ATC
clindamycin; systemic
4.8
13.4
48
163
ZXE20
NOMESCO Finland
More than three and less than five hours
6.0
13.4
29
64
J01MA12
ATC
levofloxacin; systemic
5.3
13.2
35
93
L17
ICPC
Foot/toe symptom/complaint
4.7
12.8
45
150
A46
ICD-10 Finland
Erysipelas
5.3
12.5
32
82
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
7.2
12.4
21
36
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
12.6
12.3
22
22
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
6.8
12.3
22
40
SPAT1229
SPAT
Assessment of need for aid
11.2
12.1
23
26
A28
ICPC
Limited function/disability NOS
5.2
12.0
31
80
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.0
11.8
33
91
SPAT1148
SPAT
Treatment of chronic ulcer or burn
5.6
11.7
27
63
C03CA01
ATC
furosemide; systemic
4.3
11.5
49
186
ZXD05
NOMESCO Finland
Urgent procedure
4.3
11.2
45
163
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.5
10.8
25
58
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
5.0
10.6
28
73
S18
ICPC
Laceration/cut
4.1
10.4
60
277
Z01.8
ICD-10 Finland
Other specified special examinations
4.5
10.3
32
95
S97
ICPC
Chronic ulcer skin
10.2
10.2
20
24
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
29.6
10.1
13
5
G54.0
ICD-10 Finland
Brachial plexus disorders
61.3
9.9
11
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.7
9.8
21
45
A10AE04
ATC
insulin glargine; parenteral
5.9
9.8
20
41
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
110.3
9.6
10
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
13.4
9.5
16
14
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.9
9.4
39
142
N06AX11
ATC
mirtazapine; oral
3.7
9.1
46
191
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
4.6
9.0
26
72
R51.80
ICD-10 Finland
Headache
13.4
8.9
15
13
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
55.1
8.9
10
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
5.5
8.8
19
41
X59
ICD-10 Finland
Exposure to unspecified factor
4.3
8.7
28
84
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
5.1
8.7
21
50
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.5
8.7
25
69
N02BF01
ATC
gabapentin; oral
11.0
8.7
16
17
ZXA00
NOMESCO Finland
Right side
3.7
8.6
38
143
R07.4
ICD-10 Finland
Chest pain, unspecified
3.8
8.6
35
125
WX213
NOMESCO Finland
Lower leg blockade
+∞
8.4
8
*
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
+∞
8.4
8
*
Z89.5
ICD-10 Finland
Acquired absence of leg at or below knee
+∞
8.4
8
*
WX306
NOMESCO Finland
Lumbar epidural anesthesy
10.4
8.4
16
18
R4120
NOMESCO Finland
Occupational therapy
13.4
8.4
14
12
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
24.5
8.2
11
5
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.9
8.0
20
49
N05BA04
ATC
oxazepam; oral
3.6
7.9
34
125
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.7
7.9
32
113
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
49.1
7.9
9
*
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
49.1
7.9
9
*
ZZA00
NOMESCO Finland
Split skin graft
13.4
7.8
13
11
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.2
7.8
18
41
WX212
NOMESCO Finland
Femoral plexus blockade
20.4
7.8
11
6
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
20.4
7.8
11
6
Z3226
NOMESCO Finland
Physiotherapist
4.1
7.8
26
80
A06AD11
ATC
lactulose; oral
4.6
7.7
21
55
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
7.7
56
285
Z3231
NOMESCO Finland
Registered nurse
3.4
7.7
38
153
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
7.6
29
98
N03AX09
ATC
lamotrigine; oral
12.3
7.6
13
12
N05AH04
ATC
quetiapine; oral
4.3
7.5
23
66
PE1AT
NOMESCO Finland
Femoral artery PTA
86.4
7.5
8
*
A02BC03
ATC
lansoprazole; oral
3.5
7.5
35
135
T36
ICD-10 Finland
Poisoning by systemic antibiotics
22.0
7.3
10
5
A02BC01
ATC
omeprazole; systemic
3.5
7.3
34
131
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
7.8
7.2
16
24
N05CF01
ATC
zopiclone; oral
3.2
7.1
43
194
R50.9
ICD-10 Finland
Fever, unspecified
4.1
7.1
23
69
N05CD07
ATC
temazepam; oral
4.4
7.1
20
54
M54.5
ICD-10 Finland
Low back pain
3.5
7.0
32
121
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.7
7.0
28
97
ZXE10
NOMESCO Finland
More than one and less than three hours
3.1
7.0
44
203
SPAT1301
SPAT
No procedures
3.1
7.0
43
196
M03BX01
ATC
baclofen; systemic
43.2
6.9
8
*
A01
ICPC
Pain general/multiple sites
6.6
6.8
17
30
M54.9
ICD-10 Finland
Dorsalgia, unspecified
9.8
6.8
13
15
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
3.1
6.8
59
325
B01AA03
ATC
warfarin; systemic
3.5
6.7
28
100
R06.0
ICD-10 Finland
Dyspnoea
3.2
6.5
34
139
M79.0
ICD-10 Finland
Rheumatism, unspecified
74.5
6.5
7
*
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
74.5
6.5
7
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
8.0
6.5
14
20
ZXE30
NOMESCO Finland
More than five and less than seven hours
8.0
6.5
14
20
X58
ICD-10 Finland
Exposure to other specified factors
4.0
6.4
21
63
M54.4
ICD-10 Finland
Lumbago with sciatica
4.4
6.4
18
48
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.0
6.4
49
249
I74.3
ICD-10 Finland
Embolism and thrombosis of arteries of lower extremities
28.7
6.3
8
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.4
6.3
16
29
NGM10
NOMESCO Finland
Fasciotomy of of knee or lower leg
+∞
6.3
6
*
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
+∞
6.3
6
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.6
6.3
14
21
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.6
6.3
25
86
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
3.1
6.3
34
142
P06
ICPC
Sleep disturbance
4.1
6.3
19
54
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.1
6.2
36
156
205
Kela drug reimbursment
Chronic hypertension
3.1
6.1
35
151
B01AC04
ATC
clopidogrel; oral
3.4
6.1
27
100
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
16.3
6.0
9
6

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
32
76
5.79
13.71
3.1
1.6
—
—
—
0
0
51
193
4.46
12.16
9.6
3.7
—
—
—
0
0
34
104
4.49
10.53
3.6
2.4
18.67
23.88
%
1.13
27
87
26
78
4.19
8.08
1.4
1.3
—
—
—
0
0
63
339
3.45
7.93
8.1
5.6
10.11
12.06
umol/l
1.19
63
326
44
191
3.39
7.89
5.0
2.8
—
—
—
0
0
30
103
3.77
7.70
6.9
1.7
—
—
—
0
0
22
69
3.83
6.34
7.0
7.4
94.58
95.65
%
0.16
22
69
16
30
6.17
6.18
9.8
9.0
—
—
—
0
0
44
216
2.90
6.08
3.7
3.2
2116.95
66.94
mg/l
0.78
36
150
52
282
2.82
5.92
2.2
2.0
92.93
93.41
pmol/l
0.02
29
148
76
508
3.29
5.79
7.6
3.4
17.04
12.97
mm/h
1.08
76
464
41
201
2.80
5.59
3.4
2.0
106.95
807.09
u/l
1.14
41
186
20
64
3.68
5.57
10.6
7.4
118.70
123.30
g/l
0.39
20
64
27
105
3.18
5.56
6.0
3.4
356.33
512.11
ng/l
0.14
21
84
16
45
4.06
5.30
12.4
8.6
24.61
24.90
mmol/l
0.14
16
45
8
6
14.36
5.17
12.9
11.2
11.80
12.07
mg/l
—
8
6
58
349
2.65
5.16
9.0
4.8
1.88
1.80
e9/l
0.26
52
311
21
73
3.40
5.15
1.9
1.6
—
—
—
0
0
9
9
10.87
5.14
1.8
1.7
—
—
—
0
0
56
335
2.59
4.99
23.2
14.6
1.70
1.29
inr
—
9
100
17
54
3.60
4.75
5.5
4.9
—
—
—
0
0
56
341
2.52
4.72
9.4
4.7
0.05
0.04
e9/l
1.46
50
298
7
6
12.43
4.34
1.7
1.8
—
—
—
0
0
56
350
2.42
4.34
9.6
5.2
0.23
0.18
e9/l
1.91
51
310
55
342
2.40
4.30
9.4
4.7
0.65
0.58
e9/l
0.97
50
301
42
232
2.43
4.28
4.5
3.8
20.55
10.57
mg/mmol
0.62
31
152
25
107
2.80
4.28
4.2
2.6
0.78
0.83
mmol/l
1.28
25
102
60
392
2.39
4.14
12.5
8.6
4.18
4.01
e9/l
0.26
55
351
20
77
3.01
4.12
2.3
1.4
—
—
—
0
0
17
61
3.17
3.93
2.1
2.6
425.41
427.09
nmol/l
0.01
17
54
38
208
2.36
3.89
4.7
1.9
—
—
—
0
0
11
25
4.82
3.75
7.7
2.4
23.44
24.07
mmol/l
0.25
11
25
51
320
2.25
3.75
9.9
5.3
—
—
—
0
0
23
101
2.67
3.72
2.5
1.9
31.00
28.97
s
0.68
23
96
66
468
2.28
3.52
8.4
3.4
—
—
—
0
0
15
55
3.04
3.33
7.9
2.8
—
—
—
0
0
88
739
3.05
3.27
42.0
11.2
24.09
24.98
mg/l
0.11
76
577
29
151
2.31
3.25
7.4
2.9
1.02
1.02
kg/l
—
7
17
21
95
2.55
3.18
1.9
1.5
—
—
—
0
0
35
199
2.19
3.18
7.2
3.2
7.39
7.40
ph
—
5
44
13
45
3.18
3.16
1.2
2.2
—
—
—
0
0
14
51
3.04
3.14
1.4
1.5
—
—
—
0
0
10
28
3.86
2.88
1.4
1.4
—
—
—
0
0
13
48
2.97
2.85
10.6
5.9
—
—
—
0
0
10
29
3.72
2.78
1.7
2.2
0.81
2.16
g/l
—
10
24
11
35
3.41
2.75
1.7
2.3
2.09
1.51
g/l
1.31
11
30
19
88
2.44
2.73
9.4
4.8
105.47
104.52
mmol/l
0.60
19
88
23
117
2.27
2.69
2.3
1.7
—
—
—
0
0
67
508
2.03
2.63
4.8
3.8
—
—
—
0
0
43
285
1.91
2.47
6.2
3.2
32.56
59.41
ng/l
1.16
34
210
17
79
2.40
2.42
1.8
2.6
2.16
1.63
%
1.20
17
72
25
138
2.09
2.38
6.5
3.2
—
—
—
0
0
15
67
2.47
2.31
1.5
1.3
240.00
230.77
titre
—
5
13
28
164
1.99
2.27
6.4
2.3
—
—
—
0
0
88
773
2.49
2.17
42.8
14.2
3.99
3.98
mmol/l
0.11
88
751
88
774
2.47
2.16
42.4
14.0
139.14
139.80
mmol/l
1.20
88
753
10
38
2.82
2.07
2.7
3.4
8.90
9.89
g/l
—
10
31
23
131
1.99
2.00
1.4
1.1
1.28
0.80
u/ml
—
5
39
5
12
4.33
1.84
1.6
3.3
—
—
—
0
0
16
82
2.14
1.82
1.3
1.2
21.66
7.16
u/ml
—
7
34
6
18
3.48
1.77
1.5
1.0
0.19
0.23
g/l
—
6
18
18
297
0.52
1.75
2.4
2.8
—
—
—
0
0
45
333
1.66
1.62
6.4
3.1
0.00
0.00
estimate
—
8
73
7
27
2.71
1.54
2.6
2.8
—
—
—
0
0
9
38
2.51
1.50
10.1
4.8
26.12
24.46
mmol/l
—
9
38
45
340
1.60
1.45
6.4
3.1
0.00
0.00
estimate
—
7
64
5
16
3.23
1.45
1.4
1.3
—
—
—
0
0
10
47
2.26
1.39
1.1
1.1
—
—
—
0
0
28
190
1.67
1.37
6.6
2.6
16.36
390.06
e6/l
0.60
23
152
13
69
2.02
1.36
1.2
1.4
—
—
—
0
0
25
165
1.69
1.35
7.0
2.6
0.25
0.58
e6/l
0.93
20
127
9
43
2.20
1.34
8.7
5.5
1.71
1.56
%
—
9
43
9
43
2.20
1.34
12.2
6.1
0.58
0.73
%
—
9
43
44
336
1.57
1.33
8.1
4.3
0.00
0.00
estimate
—
8
69
10
50
2.11
1.21
1.4
1.4
—
—
—
0
0
5
21
2.45
1.10
1.6
1.0
1.10
1.15
g/l
—
5
21
31
227
1.54
1.10
7.2
3.0
48.44
86.93
e6/l
0.34
23
160
10
54
1.95
1.01
5.9
3.3
—
—
—
0
0
18
120
1.61
0.94
1.6
1.4
2.84
2.33
g/l
0.33
12
74
35
274
1.43
0.88
6.9
3.0
—
6.00
—
0
21
14
90
1.65
0.83
1.6
1.2
121.57
38.87
iu/ml
—
6
24
34
270
1.40
0.78
2.2
2.0
—
—
—
0
0
25
188
1.44
0.77
8.4
3.1
0.00
0.02
estimate
—
7
64
5
24
2.14
0.75
3.0
2.0
0.34
0.70
%
—
5
24
5
25
2.05
0.74
3.0
2.0
0.58
1.16
%
—
5
25
71
640
1.41
0.73
45.5
15.0
330.87
333.36
g/l
1.29
71
635
9
58
1.61
0.72
1.3
1.6
—
—
—
0
0
7
43
1.68
0.68
4.7
2.1
—
—
—
0
0
10
63
1.65
0.64
3.8
2.3
13.69
13.37
nmol/l
—
10
55
21
160
1.40
0.60
8.5
6.2
—
—
—
0
0
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
5
88
0.54
0.59
1.0
1.3
—
—
—
0
0
0
23
0.00
0.59
0.0
4.5
—
—
—
0
0
9
61
1.52
0.56
1.2
1.6
—
—
—
0
0
6
39
1.57
0.54
2.7
4.8
—
—
—
0
0
38
323
1.29
0.53
18.6
8.5
0.00
0.00
e9/l
0.80
30
264
86
817
1.46
0.50
37.2
11.9
—
—
—
0
0
8
57
1.44
0.43
1.4
2.6
2.97
7.00
ug/l
—
8
52
5
32
1.59
0.43
3.2
2.6
—
—
—
0
0
5
35
1.45
0.40
13.6
3.2
—
—
—
0
0
9
71
1.29
0.37
3.9
3.6
2.53
162.67
ug/l
—
9
58
8
66
1.23
0.27
1.3
1.4
—
—
—
0
0
89
866
1.34
0.22
52.5
17.2
30.19
30.43
pg
0.65
89
848
89
866
1.34
0.22
52.6
17.3
91.27
91.19
fl
0.06
89
848
89
866
1.34
0.22
53.1
17.4
130.34
136.68
g/l
3.32
89
849
89
865
1.35
0.22
53.2
17.3
39.09
40.44
%
1.10
77
810
23
203
1.17
0.21
1.3
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
19
210
0.88
0.14
5.3
3.9
—
—
—
0
0
78
762
1.12
0.11
5.4
4.4
6.32
5.94
mmol/l
1.19
73
699
22
203
1.11
0.11
5.8
2.7
—
—
—
0
0
5
62
0.80
0.08
12.2
2.7
—
—
—
0
0
16
174
0.90
0.08
2.5
3.0
0.41
0.74
ug/l
3.77
11
118
8
94
0.84
0.07
2.0
1.2
—
—
—
0
0
5
58
0.85
0.00
2.2
1.4
—
—
—
0
0
5
58
0.85
0.00
4.4
5.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.8
—
4.18
—
0
9
0
9
0.00
-0.00
0.0
2.8
—
107.11
—
0
9
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
146.18
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
7.24
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
1.76
—
0
5
0
9
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
62
0.97
-0.00
9.8
3.0
1.21
1.22
mmol/l
—
6
54
0
8
0.00
-0.00
0.0
28.1
—
1723.13
—
0
8
0
8
0.00
-0.00
0.0
22.0
—
998.38
—
0
8

Mortality – FinRegistry

Association

Association between endpoint PHANTOMLIMB and mortality.

Females

Parameter HR [95% CI] p-value
PHANTOMLIMB 2.807 [1.79, 4.39] < 0.001
Birth year 0.993 [0.98, 1.0] 0.11

During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 255 females with PHANTOMLIMB died.

Males

Parameter HR [95% CI] p-value
PHANTOMLIMB 2.059 [1.54, 2.76] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 349 males with PHANTOMLIMB died.

Mortality risk

Mortality risk for people of age

years, who have PHANTOMLIMB.

N-year risk Females Males
1 0.292% 0.332%
5 1.62% 1.938%
10 4.051% 5.199%
15 7.699% 10.008%
20 12.73% 16.672%

Relationships between endpoints

Index endpoint: PHANTOMLIMB – Phantom limb syndrome with pain

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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