peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
99 |
4. Check minimum number of eventsNone |
99 |
5. Include endpointsNone |
99 |
6. Filter based on genotype QC (FinnGen only) |
98 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Phantom limb syndrome
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 726 | 302 | 414 |
| Only index persons | 586 | 241 | 345 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.02 | 56.33 | 55.54 |
| Only index persons | 53.45 | 53.67 | 53.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 98 | 44 | 54 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 55.68 | 50.47 | 59.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 99
- Matched controls
- 990
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G54.6
ICD-10 Finland
Phantom limb syndrome with pain
+∞
132.1
95
*
N03AX16
ATC
[U] pregabalin
19.1
50.9
68
102
N03AX12
ATC
[U] gabapentin; oral
11.9
34.5
50
78
N02AA05
ATC
oxycodone; systemic
10.2
30.6
51
93
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
11.0
27.5
37
51
NGQ20
NOMESCO Finland
Amputation of lower leg
165.0
24.9
25
*
L28
ICPC
Limited function/disability (L)
7.4
20.4
40
83
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
8.7
19.7
30
47
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
31.1
18.4
24
10
N06AA09
ATC
amitriptyline; systemic
9.0
17.4
25
36
NFQ20
NOMESCO Finland
Amputation of femur
202.8
17.1
17
*
N02AX02
ATC
tramadol; systemic, rectal
6.0
16.2
70
285
SPAT1229
SPAT
Assessment of need for aid
8.2
15.7
24
37
N06AX21
ATC
duloxetine; oral
7.1
15.5
28
52
NHQ40
NOMESCO Finland
Amputation of toe
43.4
15.0
18
5
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
7.8
15.0
24
39
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
174.7
14.9
15
*
J01FF01
ATC
clindamycin; systemic
4.9
13.9
48
159
A46
ICD-10 Finland
Erysipelas
5.7
13.5
32
77
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.3
13.0
34
89
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
17.5
12.9
20
14
TPH07
NOMESCO Finland
Cathetrisation of artery
6.2
12.7
26
54
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
13.1
12.5
22
21
J01MA02
ATC
ciprofloxacin; systemic
4.6
12.5
62
266
N06AX16
ATC
venlafaxine; oral
5.7
12.4
28
64
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
5.3
12.0
30
75
A28
ICPC
Limited function/disability NOS
5.0
11.4
31
83
ZXE20
NOMESCO Finland
More than three and less than five hours
5.0
11.2
30
79
N03AE01
ATC
clonazepam; systemic
12.2
11.1
20
20
G56.0
ICD-10 Finland
Carpal tunnel syndrome
14.4
10.9
18
15
L17
ICPC
Foot/toe symptom/complaint
4.1
10.8
45
166
S18
ICPC
Laceration/cut
4.1
10.8
62
286
SPAT1148
SPAT
Treatment of chronic ulcer or burn
5.2
10.8
27
67
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
5.1
10.3
26
65
C03CA01
ATC
furosemide; systemic
3.9
10.2
49
199
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
29.5
10.1
13
5
G54.0
ICD-10 Finland
Brachial plexus disorders
61.2
9.9
11
*
M79.6
ICD-10 Finland
Pain in limb
3.8
9.8
57
261
R52.2
ICD-10 Finland
Other chronic pain
20.1
9.7
14
8
TPH04
NOMESCO Finland
Cathetrisation of vein
4.1
9.6
36
122
J01MA12
ATC
levofloxacin; systemic
3.9
9.0
36
127
S97
ICPC
Chronic ulcer skin
8.1
8.9
20
30
ZZA00
NOMESCO Finland
Split skin graft
18.4
8.8
13
8
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
30.6
8.7
11
*
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
98.1
8.6
9
*
Z89.5
ICD-10 Finland
Acquired absence of leg at or below knee
98.1
8.6
9
*
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
98.1
8.6
9
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
9.5
8.5
17
21
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.4
8.5
25
70
WX213
NOMESCO Finland
Lower leg blockade
+∞
8.4
8
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
5.1
8.4
20
47
ZXA00
NOMESCO Finland
Right side
3.6
8.3
39
152
ZXD05
NOMESCO Finland
Urgent procedure
3.4
8.1
46
202
A10AE04
ATC
insulin glargine; parenteral
4.9
8.0
20
49
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.5
7.9
22
59
SPAT1301
SPAT
No procedures
3.3
7.8
44
192
Z01.8
ICD-10 Finland
Other specified special examinations
3.7
7.8
32
114
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
27.5
7.7
10
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
5.0
7.6
18
42
WX725
NOMESCO Finland
Noninvasive ventilation
9.1
7.4
15
19
N05CD07
ATC
temazepam; oral
4.6
7.4
20
52
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
+∞
7.4
7
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.9
7.4
18
43
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
22.0
7.3
10
5
N06AX11
ATC
mirtazapine; oral
3.1
7.2
46
214
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.9
7.2
25
79
WX212
NOMESCO Finland
Femoral plexus blockade
15.3
7.1
11
8
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
4.2
7.0
21
59
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
6.8
7.0
17
29
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
7.4
7.0
16
25
A01
ICPC
Pain general/multiple sites
4.8
6.9
17
41
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.1
6.8
16
26
WX306
NOMESCO Finland
Lumbar epidural anesthesy
7.1
6.8
16
26
N03AX09
ATC
lamotrigine; oral
9.8
6.8
13
15
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
13.6
6.8
11
9
N05CF01
ATC
zopiclone; oral
3.1
6.7
43
199
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.4
6.7
30
112
A06AD11
ATC
lactulose; oral
3.9
6.6
22
67
SPAT1262
SPAT
Handing over of treatment supplies
3.5
6.6
27
95
X59
ICD-10 Finland
Exposure to unspecified factor
3.4
6.6
29
107
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
3.6
6.5
26
90
R4120
NOMESCO Finland
Occupational therapy
8.0
6.5
14
20
ZXE30
NOMESCO Finland
More than five and less than seven hours
7.2
6.5
15
24
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.1
6.4
36
154
I74.3
ICD-10 Finland
Embolism and thrombosis of arteries of lower extremities
28.7
6.3
8
*
NGQ48
NOMESCO Finland
Revision of exarticulation or amputation stump of knee or lower leg
+∞
6.3
6
*
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
+∞
6.3
6
*
NGM10
NOMESCO Finland
Fasciotomy of of knee or lower leg
+∞
6.3
6
*
WX704
NOMESCO Finland
Intubation
7.6
6.3
14
21
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.5
6.3
17
44
A10AB05
ATC
insulin aspart; parenteral
4.6
6.2
16
40
N02BF01
ATC
gabapentin; oral
6.1
6.2
16
30
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
16.3
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
36
109
4.62
11.36
3.6
2.1
18.36
22.45
%
0.84
28
97
26
83
3.89
7.36
1.8
1.6
—
—
—
0
0
26
84
3.84
7.23
1.9
1.7
—
—
—
0
0
26
85
3.79
7.10
9.8
14.6
5.12
5.09
kpa
0.05
26
80
63
358
3.09
6.80
4.7
2.6
—
—
—
0
0
31
124
3.18
6.13
2.3
1.7
—
—
—
0
0
54
296
2.81
6.00
2.1
1.9
93.47
93.63
pmol/l
0.01
30
144
18
54
3.85
5.47
1.4
1.6
—
—
—
0
0
10
11
9.95
5.43
2.5
1.3
—
—
—
0
0
65
408
2.73
5.32
8.6
6.9
10.11
11.73
umol/l
0.96
65
392
43
231
2.52
4.71
4.5
3.9
20.09
9.23
mg/mmol
0.75
32
156
19
67
3.27
4.53
2.5
2.9
0.23
0.22
g/l
0.09
19
60
78
566
2.78
4.32
7.5
3.9
16.87
11.88
mm/h
1.56
78
518
27
120
2.72
4.29
5.0
4.1
0.78
0.82
mmol/l
1.12
27
114
42
233
2.39
4.20
3.6
2.2
106.36
308.37
u/l
1.74
42
223
11
23
5.24
4.01
2.7
1.6
—
—
—
0
0
58
384
2.23
3.70
23.2
14.0
1.70
1.28
inr
—
9
111
34
182
2.32
3.61
4.0
2.2
—
—
—
0
0
28
151
2.19
2.85
5.9
3.4
340.41
237.98
ng/l
0.14
22
120
21
100
2.40
2.84
9.0
8.3
105.52
103.47
mmol/l
1.92
21
100
17
73
2.60
2.84
2.1
1.8
425.41
350.59
nmol/l
0.61
17
64
5
6
8.69
2.78
1.2
1.2
—
—
—
0
0
8
20
4.25
2.63
5.1
3.9
—
—
—
0
0
62
459
1.94
2.54
13.0
8.8
4.15
4.04
e9/l
0.17
57
388
6
12
5.24
2.44
1.8
1.1
—
—
—
0
0
6
14
4.49
2.18
1.8
1.6
—
—
—
0
0
5
11
4.72
1.96
1.4
1.7
—
—
—
0
0
43
304
1.73
1.88
6.2
3.5
32.56
54.68
ng/l
0.76
34
223
90
801
2.36
1.88
42.3
13.6
24.31
24.13
mg/l
0.02
78
616
6
17
3.69
1.87
1.5
1.3
0.19
0.23
g/l
—
6
17
6
19
3.29
1.69
1.8
1.6
—
—
—
0
0
6
19
3.29
1.69
1.7
1.6
—
—
—
0
0
24
149
1.81
1.60
1.5
1.2
1.28
0.80
u/ml
—
5
45
90
816
2.13
1.47
43.5
16.6
139.13
139.73
mmol/l
1.06
90
799
90
818
2.10
1.47
43.8
16.7
3.99
3.97
mmol/l
0.32
90
799
5
16
3.23
1.45
1.4
1.5
—
—
—
0
0
5
16
3.23
1.45
1.8
1.7
—
—
—
0
0
5
16
3.23
1.45
1.8
1.7
—
—
—
0
0
5
16
3.23
1.45
1.6
1.5
—
—
—
0
0
5
17
3.04
1.37
1.4
1.9
—
—
—
0
0
9
43
2.20
1.34
10.1
6.2
26.12
24.82
mmol/l
—
9
43
5
18
2.87
1.30
1.6
1.3
1.10
1.11
g/l
—
5
18
5
18
2.87
1.30
1.2
1.7
—
—
—
0
0
5
18
2.87
1.30
1.2
1.7
—
—
—
0
0
17
104
1.77
1.19
1.2
1.2
21.66
17.63
u/ml
—
7
41
5
20
2.58
1.16
2.0
2.0
—
—
—
0
0
7
32
2.28
1.10
1.3
2.8
—
—
—
0
0
9
46
2.05
1.07
1.6
1.2
—
—
—
0
0
19
125
1.64
1.03
3.8
2.6
0.76
0.81
e6/l
0.04
12
69
36
279
1.46
0.96
7.1
2.9
—
—
—
0
0
6
34
1.81
0.77
2.8
1.8
—
—
—
0
0
46
385
1.36
0.76
6.3
3.2
0.00
0.00
estimate
—
8
78
5
25
2.05
0.74
1.0
1.0
—
—
—
0
0
46
389
1.34
0.70
6.3
3.2
0.00
0.00
estimate
—
7
70
5
28
1.83
0.67
1.8
1.6
—
—
—
0
0
11
72
1.59
0.62
3.8
2.2
13.37
12.61
nmol/l
0.13
11
64
45
388
1.29
0.57
8.0
4.3
0.00
0.00
estimate
—
8
72
90
859
1.52
0.56
19.1
10.0
28.10
25.46
u/l
0.77
90
834
9
64
1.45
0.53
1.7
2.0
—
—
—
0
0
13
95
1.42
0.46
10.5
2.9
—
—
—
0
0
26
215
1.28
0.44
7.0
2.9
0.24
0.39
e6/l
0.59
21
163
52
467
1.24
0.44
3.1
2.9
—
—
—
0
0
16
123
1.36
0.44
3.8
2.8
0.13
1.06
e6/l
—
9
68
11
79
1.44
0.43
5.5
5.3
2.39
56.74
ug/l
0.54
11
68
7
104
0.65
0.42
1.7
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
5
34
1.49
0.41
2.0
1.7
—
—
—
0
0
28
238
1.25
0.38
5.6
4.7
21.48
19.76
%
0.22
11
124
15
117
1.33
0.38
1.5
1.2
121.57
29.84
iu/ml
—
6
39
11
82
1.38
0.36
1.5
2.0
1.96
1.67
%
0.53
11
69
6
44
1.39
0.35
1.7
1.4
—
—
—
0
0
25
212
1.24
0.35
8.4
3.4
0.00
0.00
estimate
—
7
71
9
119
0.73
0.29
1.7
1.6
—
—
—
0
0
9
75
1.22
0.26
2.0
2.1
—
—
—
0
0
74
769
0.85
0.23
31.4
13.2
85.22
80.48
ml/min/173m2
1.06
59
630
5
41
1.23
0.22
3.0
2.3
0.58
1.17
%
—
5
41
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
7
61
1.16
0.18
1.6
1.5
—
—
—
0
0
16
182
0.86
0.17
2.5
3.2
0.41
0.74
ug/l
3.65
11
126
33
308
1.11
0.13
7.6
3.2
—
—
—
0
0
91
899
1.15
0.07
54.1
19.5
130.09
136.54
g/l
3.50
91
885
91
898
1.17
0.07
54.2
19.6
39.06
40.40
%
1.11
78
857
80
794
1.04
0.00
5.4
4.4
6.31
5.95
mmol/l
1.19
75
722
10
97
1.03
0.00
4.3
6.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
972.71
—
0
7
0
7
0.00
0.00
0.0
2.3
—
13.01
—
0
7
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
101.17
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
112.50
—
0
6
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
12.67
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
15.80
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
115.78
—
0
9
8
80
1.00
-0.00
1.4
2.4
2.97
6.19
ug/l
—
8
68
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
6
64
0.93
-0.00
9.8
3.1
1.21
1.22
mmol/l
—
6
56
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_PHANTOM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PHANTOM | 2.961 [1.92, 4.57] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.056 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 261 females with G6_PHANTOM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PHANTOM | 2.061 [1.55, 2.74] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 119 out of 361 males with G6_PHANTOM died.
Mortality risk
Mortality risk for people of age
years, who have G6_PHANTOM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.282% | 0.327% |
| 5 | 1.348% | 2.281% |
| 10 | 3.262% | 5.933% |
| 15 | 6.514% | 10.869% |
| 20 | 12.15% | 17.885% |
Relationships between endpoints
↥Index endpoint: G6_PHANTOM – Phantom limb syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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