Phantom limb syndrome

G6_PHANTOM

peripheral nervous system disease: A disease involving the peripheral nervous system.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G54.6, G54.7 Hospital discharge: ICD-9 — 3536 Cause of death: ICD-10 — G54.6, G54.7 Cause of death: ICD-9 — 3536 2 out of 7 registries used, show all original rules.	94
4. Check minimum number of events None	94
5. Include endpoints None	94
6. Filter based on genotype QC (FinnGen only)	94

Control definitions (FinnGen only)

Control exclude: G6_NERPLEX

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	G6_PHANTOM
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G54[6-7]
HD_ICD_9	3536
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G54[6-7]
COD_ICD_9	3536
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Phantom limb syndrome based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	726	302	414
Only index persons	586	241	345
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	56.02	56.33	55.54
Only index persons	53.45	53.67	53.29

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	94	41	53
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	55.40	50.35	59.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
83: Matched controls
831

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G54.6

ICD-10 Finland

Phantom limb syndrome with pain

+∞

109.2

N03AX16

ATC

pregabalin; oral

16.7

28.6

NGQ20

NOMESCO Finland

Amputation of lower leg

294.5

22.8

N03AX12

ATC

gabapentin; oral

14.7

21.8

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

13.5

15.6

N02AA05

ATC

oxycodone; systemic

8.6

15.0

N02AX02

ATC

tramadol; systemic, rectal

6.5

14.3

209

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

18.5

12.5

N06AX21

ATC

duloxetine; oral

10.4

12.3

NHQ30

NOMESCO Finland

Amputation of foot, transmetatarsal

69.2

10.9

NHQ40

NOMESCO Finland

Amputation of toe

22.5

10.7

G54.0

ICD-10 Finland

Brachial plexus disorders

+∞

10.6

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

8.2

10.4

L28

ICPC

Limited function/disability (L)

6.6

10.2

J01FF01

ATC

clindamycin; systemic

4.8

9.9

139

Z89.5

ICD-10 Finland

Acquired absence of leg at or below knee

+∞

9.6

N06AA09

ATC

amitriptyline; systemic

7.5

9.5

NFQ20

NOMESCO Finland

Amputation of femur

56.1

8.9

G56.0

ICD-10 Finland

Carpal tunnel syndrome

18.9

8.9

M79.6

ICD-10 Finland

Pain in limb

4.3

8.8

180

A46

ICD-10 Finland

Erysipelas

5.3

8.7

L17

ICPC

Foot/toe symptom/complaint

4.5

8.3

110

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

8.6

8.0

C03CA01

ATC

furosemide; systemic

4.0

7.9

156

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

11.0

7.6

J01MA02

ATC

ciprofloxacin; systemic

3.7

7.5

231

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

5.6

7.4

S97

ICPC

Chronic ulcer skin

9.7

7.2

SPAT1229

SPAT

Assessment of need for aid

5.9

7.1

R52.2

ICD-10 Finland

Other chronic pain

12.5

7.1

PF1AT

NOMESCO Finland

Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)

43.8

6.9

N06AX16

ATC

venlafaxine; oral

5.1

6.8

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

4.4

6.7

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

5.2

6.6

Z73.3

ICD-10 Finland

Stress, not elsewhere classified

75.4

6.5

PD4AC

NOMESCO Finland

Arterigography of lower extremity with X-ray

19.9

6.4

E10.7

ICD-10 Finland

Type 1 diabetes mellitus, With multiple complications

29.1

6.4

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

+∞

6.3

N06AX11

ATC

mirtazapine; oral

3.4

6.3

165

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

100

4.76

11.18

4.0

1.9

18.7

22.6

0.72

(3007853) Bacteria identified in Skin by Aerobe culture

4.89

10.24

3.2

1.5

—

(3023368) Bacteria identified in Blood by Culture

207

3.54

8.39

9.8

4.5

—

(3042936) Bacteria identified in Isolate by Culture

101

3.71

7.28

7.0

2.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

5.01

6.79

11.1

22.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

336

3.17

6.77

7.6

4.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.79

6.41

1.9

1.7

—

(40768797) Stomach Pathology biopsy report

3.60

6.32

1.4

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.74

6.29

2.0

1.7

—

(3026008) Bacteria identified in Urine by Culture

207

2.99

6.23

4.4

2.7

—

(3012516) Albumin [Mass/volume] in Urine

200

2.86

5.71

3.9

3.3

2235.1

60.8

mg/l

0.79

140

(3019060) Gas panel - Arterial blood

3.85

5.17

6.6

13.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

282

2.65

5.12

2.1

1.9

93.8

94.2

pmol/l

0.02

141

(3032080) INR in Blood by Coagulation assay

302

2.62

4.97

15.7

8.3

1.7

1.2

inr

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

385

2.66

4.88

8.4

6.5

10.0

11.7

umol/l

0.98

370

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

113

2.95

4.87

2.4

1.8

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.97

4.42

2.9

1.6

—

(3021788) Differential panel - Synovial fluid

9.58

4.37

1.8

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.03

4.13

1.8

1.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

7.82

3.94

2.6

1.3

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

218

2.35

3.82

3.8

2.2

104.6

296.0

u/l

1.53

209

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.31

3.77

1.5

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

3.07

3.73

2.5

2.8

0.2

g/l

0.04

(3013707) Erythrocyte sedimentation rate by Westergren method

539

2.59

3.69

7.3

3.9

16.8

11.8

mm/h

1.46

495

(3020682) Albumin/Creatinine [Ratio] in Urine

220

2.22

3.35

4.9

4.1

20.8

9.3

mg/mmol

0.69

148

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

166

2.29

3.28

3.7

2.2

—

(3018418) pH of Serum or Plasma

198

2.22

3.25

7.1

3.6

7.4

—

(3019150) Specific gravity of Urine by Refractometry

149

2.25

2.98

5.5

3.3

1.0

kg/l

—

(42870588) Differential panel, method unspecified - Blood

238

2.09

2.94

9.0

5.5

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

4.75

2.86

5.1

4.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

137

2.24

2.82

4.9

3.4

372.8

267.5

ng/l

0.13

105

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

8.71

2.78

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

218

2.06

2.74

4.4

2.2

—

(3000494) Fungus identified in Specimen by Culture

2.40

2.73

2.5

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.38

2.67

1.8

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

111

2.28

2.63

2.3

1.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

5.74

2.58

1.8

1.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.80

2.57

1.4

1.6

—

(3044889) 12 lead EKG panel

512

1.97

2.32

5.0

3.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.72

2.29

1.2

1.7

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

4.19

2.07

1.8

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

493

1.84

2.02

8.6

3.8

—

(4010399)

2.50

1.97

1.5

1.3

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

4.73

1.96

1.4

1.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

249

1.80

1.95

4.7

3.1

2.3

2.4

mmol/l

1.14

218

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.68

1.90

1.4

1.3

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.24

1.81

2.2

1.9

408.6

353.5

nmol/l

0.45

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

759

2.25

1.75

40.7

13.2

23.9

24.6

mg/l

0.08

584

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.30

1.69

1.7

1.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.30

1.69

1.8

1.6

—

(3049717) Cytology report of Urine Cyto stain

2.64

1.64

2.4

2.3

—

(1761868) Lipid panel - Serum or Plasma

291

0.53

1.63

2.4

2.7

—

(36660697) Celiac disease serology panel - Serum

2.42

1.59

1.3

1.1

—

(3028026) IgM [Mass/volume] in Serum or Plasma

2.42

1.59

2.0

1.7

0.8

1.1

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.72

1.55

1.3

1.4

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

3.46

1.54

1.2

1.3

0.2

g/l

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

291

1.65

1.54

6.3

3.5

32.9

54.0

ng/l

0.66

210

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.24

1.45

1.4

1.3

—

(3027945) Reticulocytes/100 erythrocytes in Blood

1.96

1.41

1.8

2.9

2.0

1.7

0.53

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.26

1.38

1.6

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.05

1.37

1.6

1.5

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

771

2.07

1.36

42.7

16.1

139.2

139.8

mmol/l

1.03

754

(3023103) Potassium [Moles/volume] in Serum or Plasma

773

2.04

1.36

42.9

16.1

4.0

mmol/l

0.21

754

(3012544) pH of Venous blood

1.99

1.31

8.5

3.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.72

1.23

1.0

1.1

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.08

1.16

2.8

2.1

9.0

10.1

g/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

158

1.60

1.07

4.1

3.2

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.34

1.04

1.0

—

(3000991) Gas panel - Venous blood

1.91

1.03

11.9

7.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

257

1.44

0.86

6.3

2.8

—

(36304419) Bacteria [Presence] in Urine

194

1.47

0.84

6.4

2.6

—

(3022313) Gas panel - Capillary blood

1.93

0.83

2.3

2.9

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.79

0.0

4.3

—

(3035350) Ketones [Presence] in Urine by Test strip

357

1.38

0.76

5.1

3.2

0.0

estimate

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.14

0.76

1.8

1.6

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.86

0.74

11.7

5.5

26.6

24.7

mmol/l

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

102

1.56

0.73

1.3

0.9

19.4

u/ml

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

112

1.52

0.69

3.5

2.6

0.7

0.8

e6/l

0.11

(3009261) Glucose [Presence] in Urine by Test strip

362

1.35

0.68

5.1

3.2

0.0

estimate

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.69

0.64

3.4

2.6

5.2

5.0

kpa

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.70

0.62

2.0

1.7

—

(40768800) Prostate Pathology biopsy report

0.00

0.60

0.0

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

361

1.30

0.55

6.7

4.3

0.0

estimate

—

(40761535) Cells panel - Urine sediment

1.47

0.54

3.3

3.0

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.53

0.53

5.5

5.2

2.4

61.1

ug/l

0.54

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.42

0.52

1.3

1.6

—

(3013512) EKG study

241

0.73

0.52

6.3

3.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

691

1.33

0.48

37.8

13.7

39.1

40.1

0.44

499

(3015736) pH of Urine

279

1.28

0.48

5.3

2.9

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

814

1.46

0.47

18.6

9.8

28.5

25.6

u/l

0.80

790

(3022145) Colonoscopy Study observation

1.45

0.47

1.5

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.45

0.47

11.3

2.9

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

223

1.30

0.47

5.6

4.7

20.5

19.6

—

115

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.50

0.46

3.6

2.2

14.1

12.6

nmol/l

—

(3022621) pH of Urine by Test strip

1.43

0.46

4.7

2.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.50

0.44

1.8

2.0

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.65

0.44

3.2

1.9

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.41

0.0

1.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

112

0.69

0.40

1.8

1.6

—

(3000492) Spirometry study

1.34

0.38

1.6

1.4

—

(21494755) Public health laboratory ask at order entry panel

0.64

0.37

1.0

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

201

1.26

0.37

6.2

3.3

0.0

estimate

—

(3007164) IgA [Mass/volume] in Serum or Plasma

136

1.31

0.37

1.8

1.3

2.6

2.3

g/l

0.16

(3002256) Pathology report gross observation

0.65

0.34

1.2

1.3

—

(3022217) INR in Platelet poor plasma by Coagulation assay

101

1.33

0.34

28.2

24.3

—

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

726

0.81

0.32

30.5

12.6

84.6

80.9

ml/min/173m2

0.70

597

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

111

1.31

0.32

3.9

2.9

0.1

1.1

e6/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

442

1.18

0.28

3.1

3.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.23

0.27

2.1

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.37

0.24

3.2

1.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.72

0.23

1.7

1.4

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.30

0.23

1.6

2.1

2.0

1.7

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.30

0.23

1.0

1.3

—

(3018095) Leukocytes [#/volume] in Urine

261

1.16

0.22

7.0

3.4

50.2

59.4

e6/l

0.11

187

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.0

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.21

0.0

1.7

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.0

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

1.7

—

11.8

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.0

—

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.0

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.21

0.0

1.5

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

2.9

—

3.9

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

2.9

—

106.8

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

2.9

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

1.8

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.20

0.0

1.9

—

(40761511) CBC panel - Blood by Automated count

808

1.23

0.19

38.8

12.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

293

1.14

0.19

6.0

3.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.20

0.18

1.6

1.5

—

(4035726)

1.20

0.18

1.3

1.6

—

(40758558) Short blood count panel - Blood

178

1.16

0.17

8.2

6.1

—

(3003694) ABO and Rh group [Type] in Blood

189

1.14

0.15

1.3

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

160

1.15

0.15

6.9

5.6

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

170

0.86

0.15

2.1

3.1

0.4

0.7

ug/l

—

117

(40768804) Tissue Pathology biopsy report

307

1.12

0.15

2.2

2.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

114

1.16

0.12

1.5

1.2

131.3

31.3

iu/ml

—

(40761536) Microorganisms panel - Urine sediment

0.80

0.08

12.2

2.7

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.10

0.08

1.4

2.5

3.0

6.4

ug/l

—

(3000963) Hemoglobin [Mass/volume] in Blood

849

1.15

0.07

52.7

19.2

130.4

136.7

g/l

3.30

835

(3024731) MCV [Entitic volume]

849

1.15

0.07

52.2

19.0

91.3

91.2

0.05

835

(3035941) MCH [Entitic mass]

849

1.15

0.07

52.2

19.0

30.2

30.4

0.50

835

(3021589) Normoblasts [#/volume] in Blood

346

1.07

0.06

19.0

9.8

0.0

e9/l

0.80

275

(3041096) Erythrocytes [Presence] in Urine by Automated

212

1.05

0.02

5.8

2.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

755

0.97

0.00

5.5

4.4

6.2

5.9

mmol/l

0.92

686

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.1

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(4024509)

0.00

0.0

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.4

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.3

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.3

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.7

—

972.7

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.1

—

(4027681)

0.00

0.0

1.2

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.3

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

1.7

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.96

0.00

4.6

6.7

—

(3000012) Reticulocyte production index

0.00

0.0

1.9

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

2.0

—

12.7

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.3

—

117.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.6

—

117.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.92

0.00

2.2

1.4

—

(4281824)

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.1

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.6

—

6.8

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.1

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

2.9

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.00

0.00

9.8

2.7

1.2

mmol/l

—

(4268621)

0.00

0.0

2.0

—

(3019225) pH of Specimen

0.95

0.00

4.5

4.4

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.3

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

2.3

—

13.0

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.0

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

2.2

—

15.8

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_PHANTOM and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_PHANTOM	2.961 [1.92, 4.57]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.056

During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 261 females with G6_PHANTOM died.

Males

Parameter	HR [95% CI]	p-value
G6_PHANTOM	2.061 [1.55, 2.74]	< 0.001
Birth year	0.985 [0.98, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 119 out of 361 males with G6_PHANTOM died.

Mortality risk

Mortality risk for people of age

years, who have G6_PHANTOM.

N-year risk	Females	Males
1	0.282%	0.327%
5	1.348%	2.281%
10	3.262%	5.933%
15	6.514%	10.869%
20	12.15%	17.885%

Relationships between endpoints

↥

Index endpoint: G6_PHANTOM – Phantom limb syndrome

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Phantom limb syndrome

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints