vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
193 |
4. Check minimum number of eventsNone |
193 |
5. Include endpointsNone |
193 |
6. Filter based on genotype QC (FinnGen only) |
193 |
Control definitions (FinnGen only)
- Control exclude
- F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F01
- Name in latin
- Dementia vascularis subito incipiens
Similar endpoints
↥List of similar endpoints to
Vascular dementia (sudden onset)
based on the number of shared cases.
Similar with more cases:
- Vascular dementia
- Any dementia
- Any dementia, excluding more controls
- Dementia
- Dementia, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3652 | 1906 | 1688 |
| Only index persons | 2020 | 1098 | 922 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 80.97 | 82.95 | 78.80 |
| Only index persons | 81.43 | 83.51 | 78.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 193 | 53 | 140 |
| Unadjusted period prevalence (%) | 0.05 | 0.02 | 0.06 |
| Median age at first event (years) | 78.01 | 79.12 | 77.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 182
- Matched controls
- 1818
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F01.0
ICD-10 Finland
Vascular dementia of acute onset
+∞
260.0
181
*
F01.9
ICD-10 Finland
Vascular dementia, unspecified
1369.8
88.4
79
*
F03
ICD-10 Finland
Unspecified dementia
53.1
47.5
56
15
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
+∞
25.6
24
*
N05AX08
ATC
risperidone; systemic
12.5
25.2
47
49
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
22.3
21
*
N06DA02
ATC
donepezil; oral
+∞
21.2
20
*
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
+∞
18.0
17
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
5.6
17.7
58
140
N06DX01
ATC
memantine; oral
55.7
17.4
20
*
G30.1
ICD-10 Finland
Alzheimer disease with late onset
70.1
17.1
19
*
N05AH04
ATC
quetiapine; oral
7.5
16.2
40
66
F01.1
ICD-10 Finland
Multi-infarct dementia
+∞
14.8
14
*
N06DA03
ATC
rivastigmine; oral, transdermal
+∞
13.7
13
*
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
139.0
12.6
13
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.5
11.3
61
227
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
+∞
10.5
10
*
WYA20
NOMESCO Finland
Home visit
16.2
9.7
15
10
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
+∞
9.4
9
*
N06DA04
ATC
galantamine; oral
+∞
9.4
9
*
N06AB04
ATC
citalopram; systemic
3.3
9.4
52
195
R41.0
ICD-10 Finland
Disorientation, unspecified
8.2
9.2
20
27
F01
ICD-10 Finland
Vascular dementia
29.0
8.6
11
*
N05AD03
ATC
melperone; systemic
10.8
8.2
15
15
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
35.0
8.2
10
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.9
8.0
19
30
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
4.3
7.9
29
76
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
7.9
89
507
A28
ICPC
Limited function/disability NOS
3.0
7.6
48
193
G30.8
ICD-10 Finland
Other Alzheimer disease
83.3
7.5
8
*
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
4.7
7.5
25
60
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
6.1
7.3
19
34
Z75.5
ICD-10 Finland
Holiday relief care
9.4
7.2
14
16
N05AH03
ATC
olanzapine; systemic
12.7
7.2
12
10
N30.0
ICD-10 Finland
Acute cystitis
3.4
7.0
34
114
B01AC07
ATC
dipyridamole; systemic
3.0
6.8
41
159
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.4
6.8
33
111
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
6.7
71
382
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.6
6.4
21
50
N05BA04
ATC
oxazepam; oral
2.6
6.4
52
242
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.7
6.3
45
195
F05.1
ICD-10 Finland
Delirium superimposed on dementia
+∞
6.3
6
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.1
6.2
13
17
N06AB10
ATC
escitalopram; oral
3.8
6.1
25
73
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
3.3
6.0
30
103
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
44
738
0.48
4.50
4.4
5.0
2.2
2.3
mmol/l
0.33
44
651
42
704
0.48
4.21
4.0
4.5
1.2
1.4
mmol/l
1.92
42
623
42
686
0.50
3.78
3.8
4.0
1.3
1.2
mmol/l
0.37
42
601
47
736
0.52
3.68
4.9
5.2
6.3
6.2
mmol/l
0.22
42
641
35
533
0.58
2.23
3.1
3.5
14.4
15.4
pmol/l
1.23
35
462
53
698
0.67
1.71
26.5
19.5
64.1
64.6
ml/min/173m2
0.05
46
572
65
817
0.69
1.61
34.8
23.3
102.8
93.8
umol/l
0.36
65
817
0
42
0.00
1.54
0.0
2.5
—
0.0
—
0
33
0
44
0.00
1.53
0.0
2.4
—
35.3
—
0
32
0
45
0.00
1.52
0.0
2.5
—
1.0
—
0
33
22
344
0.59
1.50
3.0
2.9
96.0
155.2
ug/l
1.30
22
317
14
73
1.99
1.48
1.3
1.4
—
—
—
0
0
23
348
0.62
1.38
5.2
4.6
19.3
23.2
%
—
9
182
0
38
0.00
1.36
0.0
3.7
—
31.8
—
0
31
0
38
0.00
1.36
0.0
2.6
—
0.0
—
0
31
0
40
0.00
1.34
0.0
2.5
—
0.0
—
0
31
14
236
0.56
1.27
1.8
1.8
465.8
432.1
pmol/l
0.23
14
197
35
459
0.71
1.03
7.6
7.4
5.1
4.5
e9/l
0.59
28
396
54
654
0.76
0.94
7.3
6.4
82.1
85.9
u/l
0.25
48
606
70
813
0.78
0.87
31.8
19.5
32.7
30.1
mg/l
0.27
63
686
10
58
1.76
0.81
2.9
1.6
—
—
—
0
0
5
27
1.87
0.69
1.0
1.5
—
—
—
0
0
5
27
1.87
0.69
1.0
1.5
—
—
—
0
0
33
409
0.77
0.67
4.2
4.2
33.0
33.6
g/l
0.26
28
376
8
51
1.59
0.61
3.0
1.4
—
—
—
0
0
25
317
0.76
0.60
7.6
5.3
—
—
—
0
0
9
61
1.50
0.54
2.8
1.4
417.7
402.9
nmol/l
—
9
51
9
65
1.40
0.51
4.1
5.0
25.3
23.7
mmol/l
—
9
59
7
106
0.65
0.50
2.7
4.6
33.7
33.0
%
—
7
65
24
191
1.29
0.49
32.8
34.9
2.0
1.5
inr
1.51
13
25
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
23
188
1.25
0.40
2.5
1.8
—
—
—
0
0
5
35
1.44
0.39
1.4
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
5
78
0.63
0.36
2.2
2.2
27.8
34.4
u/l
—
5
60
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
4.0
—
216.2
—
0
14
0
14
0.00
0.20
0.0
3.9
—
—
—
0
0
26
234
1.13
0.18
3.2
2.5
35.6
34.1
u/l
0.05
26
227
35
379
0.91
0.16
3.9
4.6
—
—
—
0
0
6
75
0.79
0.16
2.5
1.5
—
—
—
0
0
39
418
0.92
0.15
2.2
2.3
83.9
88.9
pmol/l
0.49
25
229
14
125
1.13
0.10
1.7
1.7
—
—
—
0
0
11
97
1.14
0.09
5.0
4.1
—
—
—
0
0
7
82
0.85
0.07
3.0
3.2
81.6
94.1
ng/l
—
7
73
38
364
1.05
0.07
3.5
3.9
—
—
—
0
0
53
545
0.96
0.05
5.1
4.5
7.2
6.9
mmol/l
0.34
48
520
29
303
0.95
0.05
3.0
2.1
—
—
—
0
0
41
424
0.96
0.05
5.8
4.9
44.3
62.7
ng/l
0.69
30
349
26
269
0.96
0.02
3.1
2.2
50.7
54.9
u/l
0.53
26
240
12
124
0.97
0.00
2.8
4.6
11.5
11.0
kpa
0.16
12
116
13
126
1.03
0.00
1.8
1.7
—
—
—
0
0
12
123
0.97
0.00
2.8
4.6
5.2
5.1
kpa
0.19
12
114
22
218
1.01
0.00
1.8
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
4.9
—
187.3
—
0
7
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
114.8
—
0
5
0
6
0.00
0.00
0.0
1.3
—
57.4
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint VD_SO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_SO | 2.85 [2.38, 3.42] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.079 |
During the follow-up period (1.1.1998 — 31.12.2019), 1283 out of 1533 females with VD_SO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_SO | 3.491 [2.72, 4.49] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1130 out of 1336 males with VD_SO died.
Mortality risk
Mortality risk for people of age
years, who have VD_SO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.215% | 0.773% |
| 5 | 1.352% | 4.001% |
| 10 | 3.941% | 9.908% |
| 15 | 7.694% | 18.216% |
| 20 | 12.433% | 28.948% |
Relationships between endpoints
↥Index endpoint: VD_SO – Vascular dementia (sudden onset)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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