vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
198 |
4. Check minimum number of eventsNone |
198 |
5. Include endpointsNone |
198 |
6. Filter based on genotype QC (FinnGen only) |
187 |
Control definitions (FinnGen only)
- Control exclude
- F5_DEMENTIA, G6_ALZHEIMER, G6_AD_STRICT
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F01
- Name in latin
- Dementia vascularis subito incipiens
Similar endpoints
↥List of similar endpoints to
Vascular dementia (sudden onset)
based on the number of shared cases.
Similar with more cases:
- Vascular dementia
- Any dementia
- Any dementia, excluding more controls
- Dementia
- Dementia, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 187 | 53 | 134 |
| Unadjusted period prevalence (%) | 0.05 | 0.02 | 0.06 |
| Median age at first event (years) | 78.31 | 80.52 | 77.44 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 198
- Matched controls
- 1980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F01.0
ICD-10 Finland
Vascular dementia of acute onset
+∞
283.3
197
*
F01.9
ICD-10 Finland
Vascular dementia, unspecified
1623.3
101.5
90
*
F03
ICD-10 Finland
Unspecified dementia
223.8
63.1
62
*
N05AX08
ATC
risperidone; systemic
13.4
50.1
54
54
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
25.6
24
*
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
+∞
25.6
24
*
N05AH04
ATC
quetiapine; oral
6.7
24.1
44
81
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
5.1
22.7
60
155
N06DX01
ATC
memantine; oral
86.0
21.2
23
*
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
+∞
20.1
19
*
G30.1
ICD-10 Finland
Alzheimer disease with late onset
81.8
20.1
22
*
F01.1
ICD-10 Finland
Multi-infarct dementia
+∞
19.1
18
*
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
+∞
15.8
15
*
N06DA02
ATC
donepezil; oral
31.5
15.5
20
7
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
5.2
13.8
31
68
N06DA03
ATC
rivastigmine; oral, transdermal
149.8
13.6
14
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.3
12.9
65
257
F01
ICD-10 Finland
Vascular dementia
+∞
12.6
12
*
N05BA04
ATC
oxazepam; oral
3.2
12.1
63
252
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
5.7
11.6
23
45
R41.0
ICD-10 Finland
Disorientation, unspecified
10.1
10.8
21
23
N06AB04
ATC
citalopram; systemic
3.1
10.7
54
211
G30.8
ICD-10 Finland
Other Alzheimer disease
115.9
10.5
11
*
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
+∞
10.5
10
*
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
4.4
10.4
28
71
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.1
10.3
54
215
WYA20
NOMESCO Finland
Home visit
11.5
10.0
18
17
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
104.8
9.5
10
*
N06DA04
ATC
galantamine; oral
104.8
9.5
10
*
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
104.8
9.5
10
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.5
9.4
36
118
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
3.6
9.3
33
103
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.9
8.8
20
44
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
93.9
8.5
9
*
Z75.5
ICD-10 Finland
Holiday relief care
10.1
8.5
16
17
N30.0
ICD-10 Finland
Acute cystitis
3.1
8.2
38
140
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.7
7.8
19
31
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.6
7.7
19
45
A28
ICPC
Limited function/disability NOS
2.5
7.3
55
261
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
7.3
94
566
N05AH03
ATC
olanzapine; systemic
12.7
7.2
12
10
N06AB10
ATC
escitalopram; oral
3.5
6.8
25
79
G04BD07
ATC
tolterodine; oral
3.6
6.5
22
66
R53
ICD-10 Finland
Malaise and fatigue
2.3
6.4
57
291
B01AC07
ATC
dipyridamole; systemic
2.6
6.4
42
186
N05AD01
ATC
haloperidol; systemic
5.4
6.4
18
36
F01.30
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without additional symptoms
+∞
6.3
6
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
6.3
53
264
N03AG01
ATC
valproic acid; systemic, rectal
6.4
6.1
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
760
0.53
3.68
4.4
5.1
2.22
2.34
mmol/l
0.44
49
662
47
725
0.54
3.39
4.1
4.6
1.28
1.37
mmol/l
0.81
47
633
47
707
0.56
3.01
3.8
4.1
1.28
1.20
mmol/l
0.34
47
612
52
756
0.58
2.91
5.0
5.3
6.30
6.21
mmol/l
0.17
47
653
5
170
0.28
2.85
4.8
2.4
2.25
2.19
g/l
—
5
159
5
158
0.30
2.56
2.6
1.7
1.21
1.19
mmol/l
—
5
125
15
69
2.27
2.10
1.3
1.4
—
—
—
0
0
39
553
0.63
1.78
3.2
3.6
14.71
15.30
pmol/l
0.60
39
479
0
46
0.00
1.73
0.0
2.6
—
35.47
—
0
34
0
47
0.00
1.73
0.0
2.7
—
1.07
—
0
35
0
42
0.00
1.54
0.0
2.8
—
0.00
—
0
33
0
44
0.00
1.53
0.0
2.7
—
0.00
—
0
35
57
719
0.71
1.37
26.1
19.4
62.67
64.51
ml/min/173m2
0.25
50
590
0
40
0.00
1.34
0.0
2.9
—
0.00
—
0
33
23
340
0.63
1.24
5.2
4.5
19.32
23.10
%
—
9
180
24
351
0.64
1.23
3.0
2.8
92.46
151.70
ug/l
1.41
24
322
11
57
1.98
1.19
2.9
1.6
—
—
—
0
0
19
288
0.62
1.14
3.4
3.7
18.25
12.43
mg/mmol
0.24
14
189
15
240
0.59
1.13
1.7
1.8
465.93
442.92
pmol/l
0.16
15
200
74
872
0.76
1.08
39.1
28.0
36.60
37.59
%
0.31
61
781
9
50
1.84
0.98
3.0
1.4
—
—
—
0
0
37
473
0.73
0.93
7.5
7.5
5.24
4.48
e9/l
0.77
30
405
35
430
0.77
0.66
4.1
4.2
33.13
33.66
g/l
0.23
29
391
10
62
1.65
0.66
2.8
1.4
430.20
410.40
nmol/l
—
10
52
5
30
1.68
0.62
1.0
1.5
—
—
—
0
0
5
30
1.68
0.62
1.0
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
59
670
0.83
0.55
7.0
6.4
81.30
86.69
u/l
0.42
53
615
75
832
0.84
0.53
31.2
19.3
31.75
31.15
mg/l
0.06
68
701
15
109
1.41
0.52
4.1
3.3
2.75
2.06
mmol/l
—
8
83
24
191
1.29
0.49
2.5
1.7
—
—
—
0
0
10
70
1.45
0.42
3.8
4.8
24.16
23.78
mmol/l
—
10
65
0
15
0.00
0.41
0.0
3.9
—
215.27
—
0
15
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
3.2
—
81.18
—
0
17
5
34
1.48
0.40
1.4
1.4
—
—
—
0
0
5
80
0.62
0.36
2.2
2.2
27.80
34.05
u/l
—
5
62
42
370
1.17
0.36
3.3
3.7
—
—
—
0
0
35
399
0.85
0.34
6.7
4.7
0.00
0.00
estimate
—
6
81
28
242
1.18
0.30
3.0
2.6
34.54
36.98
u/l
0.09
28
235
10
128
0.77
0.27
3.7
5.6
105.20
103.99
mmol/l
—
10
128
5
38
1.32
0.23
2.6
4.3
26.60
30.42
mg/l
—
5
30
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
3.06
—
0
10
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
29
322
0.88
0.20
7.4
5.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
3.6
—
—
—
0
0
30
271
1.13
0.19
3.1
2.3
52.49
54.17
u/l
0.18
30
239
45
419
1.10
0.17
5.8
4.9
42.41
69.45
ng/l
1.06
34
346
5
67
0.74
0.17
3.4
1.4
—
—
—
0
0
24
224
1.08
0.08
1.7
2.8
—
—
—
0
0
14
127
1.11
0.08
1.7
1.6
—
—
—
0
0
32
304
1.06
0.07
3.5
2.1
—
—
—
0
0
8
74
1.08
0.07
2.1
1.7
—
—
—
0
0
14
128
1.10
0.07
2.6
4.7
4.96
5.09
kpa
0.18
14
119
11
99
1.12
0.06
5.0
3.9
—
—
—
0
0
9
102
0.88
0.06
3.3
4.7
37.00
32.68
%
—
9
62
14
129
1.09
0.06
2.6
4.7
11.18
10.88
kpa
0.12
14
121
56
551
1.02
0.02
30.5
22.7
1.95
1.51
inr
2.13
22
153
10
93
1.08
0.02
2.7
5.5
113.00
114.78
g/l
—
10
88
34
336
1.01
0.00
2.0
2.4
71.41
78.93
nmol/l
0.77
29
283
42
421
1.00
0.00
2.2
2.3
88.26
89.11
pmol/l
0.04
27
222
13
128
1.02
0.00
1.8
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.0
—
—
—
0
0
39
390
1.00
-0.00
2.2
2.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
106.17
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
9.85
—
0
6
8
83
0.96
-0.00
2.7
3.2
81.75
93.80
ng/l
—
8
73
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
31.30
—
0
8
0
7
0.00
-0.00
0.0
4.9
—
197.00
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
57.35
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: VD_SO – Vascular dementia (sudden onset)
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).