Vascular dementia

F5_VASCDEM

vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F01
  • Hospital discharge: ICD-9 4378
  • Cause of death: ICD-10 F01
  • Cause of death: ICD-9 4378

2 out of 7 registries used, show all original rules.

3715

4. Check minimum number of events

None

3715

5. Include endpoints

None

3715

6. Filter based on genotype QC (FinnGen only)

3715

Control definitions (FinnGen only)

Control exclude
F5_DEMENTIA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F00-F03
Name in latin
Dementia vascularis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 65659 37270 27252
Only index persons 40397 23852 16545
Unadjusted period prevalence (%)
Whole population 0.94 1.07 0.76
Only index persons 0.78 0.88 0.63
Median age at first event (years)
Whole population 82.41 84.09 80.27
Only index persons 83.66 85.41 81.13

-FinnGen-

Key figures

All Female Male
Number of individuals 3715 1408 2307
Unadjusted period prevalence (%) 0.81 0.48 1.02
Median age at first event (years) 80.95 82.74 79.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
3220
Matched controls
31293
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N06DX01
ATC
memantine; oral
83.8
323.0
666
97
F01.9
ICD-10 Finland
Vascular dementia, unspecified
759.7
323.0
1490
36
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
201.0
323.0
446
25
F03
ICD-10 Finland
Unspecified dementia
46.2
323.0
775
213
N06DA02
ATC
donepezil; oral
64.5
323.0
486
86
G30.1
ICD-10 Finland
Alzheimer disease with late onset
21.6
323.0
496
261
N05AX08
ATC
risperidone; systemic
11.7
323.0
776
827
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
315.7
301
*
F01.2
ICD-10 Finland
Subcortical vascular dementia
282.6
309.8
315
12
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
487.7
278.5
277
6
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
7.0
264.1
732
1267
N06DA03
ATC
rivastigmine; oral, transdermal
89.1
260.3
292
35
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
2337.5
242.1
234
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
4.9
239.6
924
2362
N05AH04
ATC
quetiapine; oral
6.3
228.8
679
1267
P20
ICPC
Memory disturbance
4.4
203.0
876
2454
N06DA04
ATC
galantamine; oral
103.7
198.5
219
22
F01.30
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without additional symptoms
142.4
192.6
206
15
F01.0
ICD-10 Finland
Vascular dementia of acute onset
957.2
189.6
186
*
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
266.3
176.6
181
7
F01.1
ICD-10 Finland
Multi-infarct dementia
+∞
174.8
168
*
F01
ICD-10 Finland
Vascular dementia
83.9
165.2
187
23
R53
ICD-10 Finland
Malaise and fatigue
3.2
157.6
1089
4349
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.3
154.6
979
3661
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
19.2
147.8
232
126
F01.3
ICD-10 Finland
Mixed cortical and subcortical vascular dementia
496.4
147.1
147
*
G30.8
ICD-10 Finland
Other Alzheimer disease
30.2
135.4
185
63
R41.0
ICD-10 Finland
Disorientation, unspecified
6.8
131.9
356
560
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.5
124.8
1408
7354
A28
ICPC
Limited function/disability NOS
2.8
122.7
998
4299
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
38.4
117.1
151
40
P70
ICPC
Dementia
14.1
108.4
191
139
SPAT1053
SPAT
Memory test
2.7
103.1
843
3576
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
28.7
98.5
136
48
F01.39
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without information on additional symptoms
250.6
97.1
100
*
N06AB04
ATC
citalopram; systemic
2.7
93.8
801
3458
F05.1
ICD-10 Finland
Delirium superimposed on dementia
40.0
93.2
119
30
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
3.2
92.1
550
1879
AA1AD
NOMESCO Finland
CT of head and brain
2.4
90.3
1046
5304
R41.3
ICD-10 Finland
Other amnesia
6.8
88.3
234
354
N03AG01
ATC
valproic acid; systemic, rectal
6.0
84.0
246
425
N06AX11
ATC
mirtazapine; oral
2.3
83.9
972
4894
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
77.6
1383
8369
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
76.1
905
4571
F01.24
ICD-10 Finland
Subcortical vascular dementia other additional symptoms of mixed type
375.4
75.2
76
*
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
9.7
75.1
158
165
N05BA04
ATC
oxazepam; oral
2.3
74.2
880
4433
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.1
73.3
313
808
N06AB10
ATC
escitalopram; oral
3.1
69.1
434
1516
F05.9
ICD-10 Finland
Delirium, unspecified
5.9
67.3
197
339
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.4
66.9
708
3348
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
139.0
65.4
70
5
L28
ICPC
Limited function/disability (L)
2.3
65.1
766
3806
A06AD11
ATC
lactulose; oral
2.1
62.3
902
4899
N05AH03
ATC
olanzapine; systemic
6.6
60.9
163
249
F01.34
ICD-10 Finland
Mixed cortical and subcortical vascular dementia are other mixed symptoms of mixed type
571.9
58.2
58
*
N05AD01
ATC
haloperidol; systemic
4.1
58.2
240
597
F01.80
ICD-10 Finland
Other specified vascular dementia without additional symptoms
151.0
57.4
61
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.5
54.5
474
2002
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
54.3
665
3329
N05AD03
ATC
melperone; systemic
5.9
54.0
158
271
SPAT1216
SPAT
Assessment of functional ability
2.2
53.8
686
3494
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
52.7
671
3411
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
67.0
52.6
61
9
4378A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Other[MULTI-INFARKTIDEMENTIA]
+∞
50.6
49
*
F01.8
ICD-10 Finland
Other vascular dementia
92.3
50.3
56
6
G30
ICD-10 Finland
Alzheimer disease
32.8
47.6
63
19
N02BE01
ATC
paracetamol; systemic, rectal
1.8
46.2
2361
18977
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.6
46.1
386
1586
F06.7
ICD-10 Finland
Mild cognitive disorder
4.4
45.5
172
393
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.1
44.5
265
882
WYA20
NOMESCO Finland
Home visit
6.0
44.2
127
213
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.7
43.5
200
546
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.3
42.8
450
2075
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.3
42.7
226
690
S72.0
ICD-10 Finland
Fracture of neck of femur
2.7
42.5
325
1267
F01.23
ICD-10 Finland
Subcortical vascular dementia other additional symptoms, mainly depression
110.8
41.3
45
*
S01.0
ICD-10 Finland
Open wound of scalp
2.6
41.2
324
1282
F0019, G301
ICD-10 Finland
NA
+∞
40.3
39
*
N30.0
ICD-10 Finland
Acute cystitis
2.1
39.7
498
2484
R55
ICD-10 Finland
Syncope and collapse
2.1
39.2
509
2575
130
Kela drug reimbursment
Malignant tumour
0.2
38.9
51
2074
R42
ICD-10 Finland
Dizziness and giddiness
1.8
37.4
821
5031
Z75.5
ICD-10 Finland
Holiday relief care
5.5
37.3
114
207
F01.14
ICD-10 Finland
Multi-infarct dementia's other mixed symptoms of mixed type
+∞
37.2
36
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
2.5
37.1
308
1253
S06.0
ICD-10 Finland
Concussion
2.4
36.9
341
1470
F01.89
ICD-10 Finland
Other specified vascular dementia without information on additional symptoms
+∞
36.1
35
*
F009, G309
ICD-10 Finland
NA
+∞
36.1
35
*
4378X
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Other[MORBUS CERBROVASCULARIS ALIA DEFINITA]
+∞
36.1
35
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.8
36.0
158
415
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
35.0
2040
16232
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.8
34.7
238
867
SPAT1254
SPAT
Administration of medicine
1.9
34.3
578
3220
I95.1
ICD-10 Finland
Orthostatic hypotension
2.8
33.6
227
818
N05BA06
ATC
lorazepam; systemic, sublingual
2.8
33.6
235
866
N06AX26
ATC
vortioxetine; oral
4.5
33.0
120
264
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
32.8
963
6386
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
5.5
32.7
100
182
W19
ICD-10 Finland
Unspecified fall
2.2
32.5
347
1602
B01AC07
ATC
dipyridamole; systemic
2.0
31.7
457
2396
K90
ICPC
Stroke/cerebrovascular accident
3.3
31.3
166
508
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.4
31.2
288
1235
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
2.9
31.2
201
704
XA800
NOMESCO Finland
Neuropsychological investigation
5.3
31.1
98
185
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.9
31.0
478
2569
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.9
30.3
196
688
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.4
29.4
269
1151
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
104.7
29.3
32
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
5.0
29.1
96
191
N30.9
ICD-10 Finland
Cystitis, unspecified
2.5
28.9
246
1012
2900A
ICD-9 Finland
Senile and presenile organic psychotic conditions, Senile dementia, uncomplicated
+∞
28.9
28
*
SPAT1234
SPAT
Support of social functional capacity
2.5
28.6
238
968
F01.21
ICD-10 Finland
Subcortical vascular dementia without additional symptoms, mainly paranoidism
147.0
28.3
30
*
A04
ICPC
Weakness/tiredness general
1.9
27.9
450
2452
F01.22
ICD-10 Finland
Subcortical vascular dementia with additional symptoms, mainly hallucinations
+∞
27.9
27
*
E86
ICD-10 Finland
Volume depletion
3.1
27.5
159
518
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
27.2
579
3465
SPAT1360
SPAT
Extensive global examination
2.3
27.1
266
1176
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
2.7
26.7
187
689
G30.0
ICD-10 Finland
Alzheimer disease with early onset
25.9
26.7
37
14
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
26.5
587
3555
A10AE04
ATC
insulin glargine; parenteral
2.1
26.4
322
1569
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
4.5
25.7
93
205
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
3.2
25.3
139
437
U04
ICPC
Incontinence urine
2.6
25.1
192
746
J01CA08
ATC
pivmecillinam; oral
1.5
24.5
979
6913
S70.0
ICD-10 Finland
Contusion of hip
2.6
24.4
187
726
F01.84
ICD-10 Finland
Other specified vascular dementia other mixed symptoms of mixed type
88.2
24.4
27
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.9
24.3
399
2184
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.7
24.1
170
629
H02AB02
ATC
dexamethasone; systemic
0.3
24.0
46
1539
J01DB01
ATC
cefalexin; oral
1.5
23.9
1959
16079
TAB00
NOMESCO Finland
Lumbar puncture
4.3
23.8
91
212
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
4.8
23.8
81
168
C10AA01
ATC
simvastatin; oral
1.5
23.6
1583
12462
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
22.9
490
2923
Z02.7
ICD-10 Finland
Issue of medical certificate
2.4
22.3
193
803
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.3
21.9
214
941
R4110
NOMESCO Finland
Physiotherapy
1.6
21.7
683
4528
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.7
21.5
152
564
F05.8
ICD-10 Finland
Other delirium
6.2
21.4
58
92
N03AF02
ATC
oxcarbazepine; oral
3.5
21.4
103
294
F01.33
ICD-10 Finland
Mixed cortical and subcortical vascular dementia other additional symptoms, mainly depression
215.1
21.4
22
*
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.6
21.3
675
4477
F21
ICPC
NA
4.9
21.2
70
141
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.4
20.7
176
724
F01.11
ICD-10 Finland
The other additional symptoms of multi-infarct dementia, mainly paranoidism
+∞
20.6
20
*
R33
ICD-10 Finland
Retention of urine
1.8
20.6
411
2396
F29
ICD-10 Finland
Unspecified nonorganic psychosis
5.2
20.5
64
121
N02AA05
ATC
oxycodone; systemic
1.6
20.4
565
3617
F02.39*G20
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
205.3
20.4
21
*
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
2.9
20.0
123
420
J01EA01
ATC
trimethoprim; systemic
1.5
19.9
854
6065
K91
ICPC
Cerebrovascular disease
4.0
19.7
80
198
F00
ICD-10 Finland
Dementia in Alzheimer disease
20.3
19.6
29
14
C03CA01
ATC
furosemide; systemic
1.4
19.3
1614
13040
103
Kela drug reimbursment
Diabetes, insulin-treated
1.5
19.1
974
7166
SPAT1229
SPAT
Assessment of need for aid
1.9
19.1
311
1690
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
2.3
18.9
179
779
SPAT1172
SPAT
Guidance concerning hydration
2.7
18.8
135
506
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
4.3
18.8
71
165
F01.31
ICD-10 Finland
Mixed cortical and subcortical vascular dementia other additional symptoms, mainly paranoidism
+∞
18.6
18
*
F22.0
ICD-10 Finland
Delusional disorder
5.0
18.5
60
119
Z02.4
ICD-10 Finland
Examination for driving licence
0.6
18.5
335
5053
A10BA02
ATC
metformin; oral
1.5
18.1
934
6870
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.8
18.1
354
2045
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.1
17.8
207
989
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
14.0
17.7
30
21
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
17.7
409
2481
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
17.7
457
2861
N05CD07
ATC
temazepam; oral
1.5
17.7
613
4132
F0009, G300
ICD-10 Finland
NA
+∞
17.5
17
*
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
+∞
17.5
17
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.6
17.5
465
2935
N06AB06
ATC
sertraline; oral
2.2
17.5
174
775
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.7
16.9
350
2056
F0029, G308
ICD-10 Finland
NA
+∞
16.5
16
*
F01.12
ICD-10 Finland
The other additional symptoms of multi-infarct dementia, mainly hallucinations
+∞
16.5
16
*
F01.32
ICD-10 Finland
Mixed cortical and subcortical vascular dementia other additional symptoms, mainly hallucinations
+∞
16.5
16
*
B01AA03
ATC
warfarin; systemic
1.4
16.5
1099
8448
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
2.3
16.4
162
718
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
1.8
16.4
272
1487
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.5
16.1
57
125
I64
ICD-10 Finland
Stroke, not specified as haemorrhage or infarction
3.9
16.0
66
167
C07AB07
ATC
bisoprolol; oral
1.4
15.9
1681
13936
N05AB03
ATC
perphenazine; systemic, rectal
3.0
15.8
92
304
S72.1
ICD-10 Finland
Pertrochanteric fracture
2.3
15.7
154
681
J01MA02
ATC
ciprofloxacin; systemic
1.4
15.6
1200
9431
N06AX21
ATC
duloxetine; oral
2.1
15.5
177
839
Y94.0
ICD-10 Finland
Accident at home
3.2
15.4
82
255
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.5
15.3
576
3947
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
2.1
15.2
175
830
N06AX16
ATC
venlafaxine; oral
2.1
15.1
175
835
A10AE05
ATC
insulin detemir; parenteral
2.2
15.1
160
735
A03FA01
ATC
metoclopramide; systemic, rectal
0.6
14.9
265
4039
R4120
NOMESCO Finland
Occupational therapy
2.2
14.9
154
698
A10BB12
ATC
glimepiride; oral
1.6
14.9
380
2368
L89
ICD-10 Finland
Decubitus ulcer and pressure area
2.8
14.8
95
334
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.7
14.7
331
1991
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
14.6
626
4407
F01.81
ICD-10 Finland
Other specified vascular dementia has other additional symptoms, mainly paranoidism
55.3
14.6
17
*
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
0.2
14.5
11
623
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
+∞
14.4
14
*
A29
ICPC
General symptom/complaint other
1.7
14.4
312
1857
G04BD07
ATC
tolterodine; oral
1.9
14.3
231
1251
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.6
14.2
104
396
NE1AA
NOMESCO Finland
Pelvis X-ray examination
1.8
14.2
241
1326
B01AC04
ATC
clopidogrel; oral
1.5
14.1
630
4468
SPAT1167
SPAT
Insertion of urinary catheter
2.1
14.1
153
711
G04CA02
ATC
tamsulosin; oral
1.4
14.0
1013
7842
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
5.0
13.8
44
87
E000001
ATC
NA
1.5
13.8
485
3266
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
2.6
13.6
96
359
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.8
13.5
87
307
WX212
NOMESCO Finland
Femoral plexus blockade
2.8
13.5
85
298
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
2.0
13.5
171
848
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.2
13.3
70
217
C09AA05
ATC
ramipril; oral
1.4
13.3
910
6968
F07.9
ICD-10 Finland
Unspecified organic personality and behavioural disorder due to brain disease, damage and dysfunction
20.6
13.1
19
9
N03AX14
ATC
levetiracetam; systemic
3.3
13.0
64
189
G46.8*I67.9
ICD-10 Finland
Other vascular syndromes of brain in cerebrovascular diseases
11.2
13.0
24
21
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
3.9
13.0
52
130
R41
ICD-10 Finland
Other symptoms and signs involving cognitive functions and awareness
5.6
12.9
37
65
N06AB03
ATC
fluoxetine; oral
1.8
12.8
236
1336
G04BD04
ATC
oxybutynin; oral, transdermal
1.7
12.7
251
1451
SPAT1262
SPAT
Handing over of treatment supplies
1.5
12.6
477
3263
R32
ICD-10 Finland
Unspecified urinary incontinence
2.6
12.4
93
360
R11
ICD-10 Finland
Nausea and vomiting
1.7
12.4
248
1442
F01.13
ICD-10 Finland
The other additional symptoms of multi-infarct dementia, mainly depression
+∞
12.4
12
*
F00.19
ICD-10 Finland
Dementia in Alzheimer's disease with late onset without information about additional symptoms
+∞
12.4
12
*
C08CA01
ATC
amlodipine; oral
1.3
12.3
1168
9385
N18
ICPC
Paralysis/weakness
2.9
12.3
74
253
SPAT1301
SPAT
No procedures
1.4
12.1
835
6387
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
3.7
12.1
51
134
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.3
12.0
1155
9295
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
1.9
11.9
179
948
EBA30
NOMESCO Finland
Excision of root of tooth
2.1
11.9
137
654
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.9
11.8
184
983
N29
ICPC
Neurological sympt/complt other
3.4
11.8
56
162
SPAT1153
SPAT
Removal of sutures
0.7
11.7
433
5717
C10AA05
ATC
atorvastatin; oral
1.3
11.6
1069
8535
R1260
NOMESCO Finland
Evaluation of communicative skills
2.9
11.6
69
234
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
11.3
945
7427
F0014, G301
ICD-10 Finland
NA
+∞
11.3
11
*
I69.8
ICD-10 Finland
Sequelae of other and unspecified cerebrovascular diseases
4.4
11.2
39
86
I67.2
ICD-10 Finland
Cerebral atherosclerosis
4.2
11.2
41
95
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
2.7
11.2
74
268
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
2.4
11.2
91
369
F10.73
ICD-10 Finland
Residual or late-onset psychosis caused by alcohol dementia
14.7
11.1
18
12
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
2.6
11.0
78
294
S06.3
ICD-10 Finland
Focal brain injury
3.3
11.0
55
166
NFJ54
NOMESCO Finland
Internal fixation of fracture of upper femur with intramedullary nail
2.3
11.0
97
412
N05CF01
ATC
zopiclone; oral
1.3
11.0
1083
8717
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
4.3
11.0
39
88
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
2.2
10.8
111
504
SPAT1101
SPAT
Orthostatic test
1.8
10.8
176
959
ZXA05
NOMESCO Finland
Left side
1.4
10.8
768
5883
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
5.9
10.7
29
48
A02BC02
ATC
pantoprazole; systemic
1.3
10.7
1636
13957
N03AX09
ATC
lamotrigine; oral
3.5
10.4
47
132
R44.1
ICD-10 Finland
Visual hallucinations
5.8
10.3
28
47
N28
ICPC
Limited function/disability (N)
3.3
10.2
51
154
315
Kela drug reimbursment
Clopidogrel
2.6
10.2
72
272
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
3.0
10.1
58
191
T90.5
ICD-10 Finland
Sequelae of intracranial injury
5.1
10.1
31
60
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
10.0
200
1164
A10BH01
ATC
sitagliptin; oral
1.6
9.9
265
1667
N03AF01
ATC
carbamazepine; oral, rectal
1.8
9.9
175
980
P29
ICPC
Psychological sympt/compl other
2.9
9.9
57
190
SPAT1157
SPAT
Guidance concerning treatment of mouth and mucous membranes
3.1
9.9
52
164
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.6
9.8
43
118
I63.8
ICD-10 Finland
Other cerebral infarction
3.1
9.8
52
165
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
1.9
9.8
140
729
S22.3
ICD-10 Finland
Fracture of rib
1.8
9.7
180
1022
G04BD08
ATC
solifenacin; oral
1.7
9.7
209
1244
F06.9
ICD-10 Finland
Unspecified mental disorder due to brain damage and dysfunction and to physical disease
11.9
9.7
17
14
W06
ICD-10 Finland
Fall involving bed
3.3
9.6
46
135
ZXA00
NOMESCO Finland
Right side
1.3
9.6
796
6227
N05AA02
ATC
levomepromazine; systemic
2.0
9.6
116
567
R44.3
ICD-10 Finland
Hallucinations, unspecified
6.1
9.6
25
40
A69
ICPC
General and Unspecified, Other reason for encounter NEC
2.2
9.6
97
438
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
1.8
9.6
163
901
R47.0
ICD-10 Finland
Dysphasia and aphasia
3.0
9.6
52
168
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
0.2
9.5
9
445
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.4
9.5
499
3625
R54
ICD-10 Finland
Senility
3.4
9.4
44
127
205
Kela drug reimbursment
Chronic hypertension
1.3
9.4
1263
10533
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
2.6
9.4
64
238
SPAT1165
SPAT
Peritoneal dialysis
8.8
9.3
19
21
S00.0
ICD-10 Finland
Superficial injury of scalp
2.4
9.3
76
310
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.4
9.3
43
124
8000/3-C34.9
ICD-O-3
Neoplasm, malignant of lung, NOS
0.3
9.2
17
577
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
2.0
9.2
114
564
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
9.2
665
5090
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.0
9.2
115
568
P99
ICPC
Psychological disorders other
4.3
9.2
33
76
S01
ICD-10 Finland
Open wound of head
3.2
9.1
45
136
G21.8
ICD-10 Finland
Other secondary parkinsonism
8.4
9.1
19
22
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
1.7
9.1
178
1030
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
3.6
9.1
39
106
S20.2
ICD-10 Finland
Contusion of thorax
1.9
8.9
124
642
T90
ICPC
Diabetes non-insulin dependent
1.4
8.9
560
4188
G04BD12
ATC
mirabegron; oral
1.5
8.9
274
1784
EBA00
NOMESCO Finland
Extraction of tooth
1.4
8.9
556
4156
N05AX12
ATC
aripiprazole; systemic
4.7
8.9
29
61
S09.9
ICD-10 Finland
Unspecified injury of head
3.5
8.9
40
113
G72.8
ICD-10 Finland
Other specified myopathies
2.5
8.9
67
262
EBA15
NOMESCO Finland
Extraction of large number of teeth
2.2
8.9
92
422
I67.8
ICD-10 Finland
Other specified cerebrovascular diseases
6.1
8.8
23
37
G20
ICD-10 Finland
Parkinson disease
2.0
8.8
114
572
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
0.3
8.7
16
543
S30.0
ICD-10 Finland
Contusion of lower back and pelvis
2.1
8.7
91
419
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.5
8.7
38
105
SPAT1252
SPAT
Overall medication plan or its review
1.6
8.7
220
1368
SPAT1246
SPAT
Screening of depression or other psychiatric problem
2.9
8.6
50
168
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
3.8
8.6
35
91
SPAT1251
SPAT
Organisation of medication
1.8
8.6
144
795
SPAT1279
SPAT
Preparation of immediate hospitalisation
2.6
8.6
62
237
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
2.1
8.6
91
424
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.6
8.6
239
1522
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.6
8.6
195
1178
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.4
8.6
70
289
F00.00
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
48.7
8.6
10
*
A46
ICD-10 Finland
Erysipelas
1.4
8.5
430
3100
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
4.4
8.5
29
64
SPAT1255
SPAT
Intravenous administration of medicine
1.7
8.5
169
982
B03BA03
ATC
hydroxocobalamin; parenteral
1.6
8.4
239
1527
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.4
8.4
71
297
F06.2
ICD-10 Finland
Organic delusional [schizophrenia-like] disorder
15.8
8.4
13
8
SPAT1138
SPAT
Guidance concerning bowel function
2.6
8.4
61
235
H53.4
ICD-10 Finland
Visual field defects
2.4
8.3
70
292
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.4
8.3
459
3362
8041/3-C34.9
ICD-O-3
Small cell carcinoma, NOS, of lung, NOS
0.0
8.3
*
232
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.4
8.3
530
3978
3310A
ICD-9 Finland
Other cerebral degenerations, Alzheimer's disease
+∞
8.2
8
*
F00, F03
ICD-10 Finland
NA
+∞
8.2
8
*
W10
ICD-10 Finland
Fall on and from stairs and steps
1.8
8.2
128
691
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
1.9
8.2
121
640
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
10.5
8.1
15
14
A10BB01
ATC
glibenclamide; oral
1.5
8.1
316
2169
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
2.1
8.1
85
395
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.6
8.1
220
1394
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
8.0
541
4088
C34.3
ICD-10 Finland
Malignant neoplasm: Lower lobe, bronchus or lung
0.2
7.9
10
416
P03
ICPC
Feeling depressed
2.2
7.9
78
350
S00.8
ICD-10 Finland
Superficial injury of other parts of head
2.9
7.9
46
156
I68.0
ICD-10 Finland
Cerebral amyloid angiopathy
21.4
7.9
11
5
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
3.3
7.9
37
109
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
3.5
7.8
34
94
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
1.7
7.8
141
799
R23.8
ICD-10 Finland
Other and unspecified skin changes
0.6
7.8
166
2443
Z73.6
ICD-10 Finland
Limitation of activities due to disability
3.5
7.7
34
95
N39.9
ICD-10 Finland
Disorder of urinary system, unspecified
2.3
7.7
67
286
F001, G301
ICD-10 Finland
NA
43.8
7.6
9
*
SPAT1304
SPAT
Counselling and guidance related to ageing
1.5
7.6
260
1734
A23
ICPC
Risk factor NOS
2.0
7.6
92
452
I63
ICD-10 Finland
Cerebral infarction
3.1
7.6
39
123
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
0.2
7.6
9
388
C04AE01
ATC
ergoloid mesylates; systemic
2.6
7.6
52
194
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.3
7.5
657
5154
SPAT1231
SPAT
Assessment of adjustments needed in living environment
2.1
7.5
83
394
U13
ICPC
Bladder symptom/complaint other
2.1
7.5
76
348
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
0.4
7.5
39
847
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.3
7.5
486
3646
D07BA04
ATC
hydrocortisone and antiseptics; topical
1.5
7.5
227
1473
SPAT1139
SPAT
Nutrition survey
2.0
7.5
87
420
Z60.8
ICD-10 Finland
Other problems related to social environment
5.7
7.5
20
34
G46.8
ICD-10 Finland
Other vascular syndromes of brain in cerebrovascular diseases
17.9
7.5
11
6
S42.2
ICD-10 Finland
Fracture of upper end of humerus
1.7
7.5
139
792
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.0
7.5
87
423
N05AF01
ATC
flupentixol; systemic
2.9
7.5
43
145
U28
ICPC
Limited function/disability (U)
2.8
7.4
45
158
XF600
NOMESCO Finland
Bloodpressure measurement
1.6
7.4
177
1083
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
1.9
7.4
109
575
K08.3
ICD-10 Finland
Retained dental root
1.7
7.4
149
872
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
1.9
7.4
111
592
F06.0
ICD-10 Finland
Organic hallucinosis
9.8
7.4
14
14
F10.09
ICD-10 Finland
Alcohol intoxication UNS
3.6
7.4
31
84
F01.83
ICD-10 Finland
Other specified vascular dementia other additional symptoms, mainly depression
78.0
7.3
8
*
R31
ICD-10 Finland
Unspecified haematuria
1.4
7.3
358
2566
SPAT1127
SPAT
Enema
2.8
7.3
43
148
H25.1
ICD-10 Finland
Senile nuclear cataract
1.2
7.3
1206
10214
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.0
7.3
94
474
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
4.7
7.2
23
48
F00.1
ICD-10 Finland
Dementia in Alzheimer disease with late onset
+∞
7.2
7
*
TKC20
NOMESCO Finland
Catheterisation of bladder
1.5
7.2
268
1821
F22.9
ICD-10 Finland
Persistent delusional disorder, unspecified
4.9
7.2
22
44
N06AA12
ATC
doxepin; systemic
1.6
7.2
160
961
A04AA02
ATC
granisetron; systemic, transdermal
0.4
7.2
21
571
S00.9
ICD-10 Finland
Superficial injury of head, part unspecified
2.9
7.1
41
138
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
2.9
7.1
41
138
F32
ICD-10 Finland
Depressive episode
2.3
7.1
60
253
S97
ICPC
Chronic ulcer skin
1.6
7.1
166
1013
SPAT1312
SPAT
General health counselling
0.7
7.1
388
4860
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
1.5
7.1
271
1853
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
2.4
7.1
56
228
H3601, E113
ICD-10 Finland
NA
2.3
7.0
60
255
Z43.5
ICD-10 Finland
Attention to cystostomy
3.3
7.0
33
98
H02AA02
ATC
fludrocortisone; oral
3.0
7.0
38
125
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.4
7.0
382
2789
F10.25
ICD-10 Finland
Alcohol dependence continuous use
3.6
7.0
29
78
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
1.8
7.0
106
569
NF1AA
NOMESCO Finland
Hip X-ray examination
1.5
7.0
257
1746
R4130
NOMESCO Finland
Speech therapy
2.3
7.0
59
250
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
0.3
6.9
17
503
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
2.9
6.9
40
135
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
1.9
6.9
97
505
XCK10
NOMESCO Finland
Photography of fundus of eye
1.4
6.9
293
2046
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.8
6.8
110
600
F10.24
ICD-10 Finland
Alcohol depence active use
4.6
6.8
22
47
Z28
ICPC
Limited function/disability (Z)
4.2
6.8
24
56
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
3.0
6.8
36
117
R1250
NOMESCO Finland
Evaluation of functional capability
2.7
6.8
42
151
N40
ICD-10 Finland
Hyperplasia of prostate
1.2
6.7
861
7071
N19
ICPC
Speech disorder
2.9
6.7
39
133
R51.80
ICD-10 Finland
Headache
1.5
6.7
215
1416
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
6.7
676
5395
D21
ICPC
Swallowing problem
2.6
6.7
47
179
P15
ICPC
Chronic alcohol abuse
3.2
6.7
33
102
L57.0
ICD-10 Finland
Actinic keratosis
0.7
6.7
195
2698
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.4
6.7
377
2770
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
2.7
6.6
41
147
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
6.5
6.6
16
24
XX1XW
NOMESCO Finland
Extensive written report from radiologist
2.5
6.6
50
198
H3600, E113
ICD-10 Finland
NA
2.3
6.6
56
235
XF606
NOMESCO Finland
Ortostatic test
3.6
6.6
28
77
N05BE01
ATC
buspirone; oral
2.5
6.6
50
199
E000003
ATC
NA
1.9
6.6
95
501
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
0.3
6.6
15
455
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.5
6.6
238
1606
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
5.9
6.6
17
28
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
2.1
6.6
72
343
S42.4
ICD-10 Finland
Fracture of lower end of humerus
2.9
6.6
38
129
G45
ICD-10 Finland
Transient cerebral ischaemic attacks and related syndromes
3.3
6.5
30
88
SPAT1125
SPAT
Stoma care and guidance
2.1
6.5
66
304
R50.9
ICD-10 Finland
Fever, unspecified
1.4
6.5
346
2517
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
4.0
6.5
24
59
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
0.3
6.5
16
467
Y94.8
ICD-10 Finland
Other leisure activity accident
2.3
6.5
55
233
S82
ICPC
Naevus/mole
0.6
6.4
88
1428
N05AC02
ATC
thioridazine; oral
2.6
6.4
43
162
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
2.6
6.4
43
162
N05BA01
ATC
diazepam; systemic, rectal
1.4
6.4
351
2564
G04BD09
ATC
trospium; oral
1.9
6.4
83
423
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.3
6.4
444
3370
S01.1
ICD-10 Finland
Open wound of eyelid and periocular area
2.2
6.3
62
282
R40.2
ICD-10 Finland
Coma, unspecified
2.7
6.3
39
141
N06AG02
ATC
moclobemide; oral
1.9
6.3
88
459
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
0.3
6.3
13
412
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
6.3
616
4897
K28
ICPC
Limited function/disability (K)
1.9
6.3
82
419
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
1.8
6.2
92
490
A48
ICPC
General and Unspecified, Clarification/discussion RFE/demand
1.9
6.2
86
447
SPAT1058
SPAT
PEF monitoring instruction
0.5
6.2
57
1031
N17
ICPC
Vertigo/dizziness
1.4
6.2
287
2032
A04AA01
ATC
ondansetron; systemic, rectal
0.5
6.2
40
806
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
0.7
6.2
213
2863
8731A
ICD-9 Finland
Other open wound of head, Scalp, complicated
+∞
6.2
6
*
SPAT1215
SPAT
Assessment of need for medical rehabilitation
1.8
6.2
93
498
QAB00
NOMESCO Finland
Suture of skin of head or neck
2.7
6.2
40
146
D07AA02
ATC
hydrocortisone; topical
1.4
6.2
286
2032
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
3.0
6.2
33
109
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
0.5
6.1
40
801
F10.20
ICD-10 Finland
Alcohol dependence currently independent
3.2
6.1
30
93
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
1.8
6.1
102
565
A01
ICPC
Pain general/multiple sites
1.6
6.0
167
1065
N43
ICPC
Neurological, Other diagnostic procedure
4.2
6.0
21
49
C34.9
ICD-10 Finland
Malignant neoplasm: Bronchus or lung, unspecified
0.3
6.0
12
387
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
2.3
6.0
52
222
T89
ICPC
Diabetes insulin dependent
2.4
6.0
49
203

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1243
6190
2.41
127.31
2.0
1.8
1050.1
1162.6
nmol/l
4.30
926
4511
134
161
8.30
99.14
3.5
3.4
321.3
325.3
umol/l
0.09
105
134
1446
8954
1.92
74.97
4.6
3.8
—
—
—
0
0
1349
8426
1.86
65.99
4.6
4.2
—
—
—
0
0
72
75
9.44
59.41
1.0
1.0
626.2
723.9
ng/l
0.69
47
37
70
75
9.17
56.56
1.0
1.0
349.7
275.8
ng/l
0.99
50
38
1176
7450
1.77
52.12
2.4
2.1
285.0
234.6
u/l
0.90
1086
6901
1551
10864
1.65
45.93
2.6
2.2
88.6
91.4
pmol/l
1.56
882
5605
2040
15543
1.60
41.05
7.5
5.7
3917.8
2032.7
e6/l
0.39
47
287
1215
8192
1.64
40.53
2.5
3.2
2.3
2.3
mmol/l
0.68
992
6775
1534
10962
1.60
40.25
4.4
4.3
33.3
33.5
g/l
0.52
1333
9923
826
5092
1.73
38.33
3.1
3.1
2.5
2.5
mmol/l
0.35
662
4266
1235
8572
1.59
35.48
2.2
2.2
75.6
81.0
nmol/l
8.29
1034
7217
1680
12606
1.53
33.44
6.3
6.4
1.2
1.2
mmol/l
1.87
1368
10453
845
5493
1.63
31.17
5.2
4.6
138.3
507.5
ng/l
1.65
772
5009
1935
15265
1.47
28.25
6.6
5.1
—
—
—
0
0
850
5656
1.59
28.04
3.8
3.0
572.0
541.6
mosm/kgh2o
4.41
715
4794
1495
11349
1.46
25.85
5.4
5.7
1.2
1.2
mmol/l
0.61
1322
10075
1881
14956
1.44
25.08
34.2
27.4
328.7
329.6
g/l
3.53
1800
14651
98
300
3.21
24.59
1.4
1.3
840.5
573.8
mg/l
0.48
91
284
1762
13877
1.43
24.56
5.4
4.7
7.3
7.0
mmol/l
5.29
1641
13030
827
5626
1.54
24.26
1.8
1.8
430.5
6763283.6
pmol/l
1.28
657
4436
1109
8072
1.47
23.27
4.4
3.6
88.1
148.0
e6/l
1.42
873
6373
88
261
3.31
23.26
1.3
1.3
4.3
4.0
mmol/l
1.39
82
233
484
2949
1.67
22.35
3.6
3.3
1.8
2.0
mmol/l
0.44
395
2319
140
548
2.53
22.33
4.6
5.4
11.4
11.3
mmol/l
0.09
127
483
140
548
2.53
22.33
4.6
5.4
104.7
104.6
mmol/l
0.04
127
483
417
2442
1.73
22.29
3.4
2.9
4.2
4.3
kpa
0.37
391
2327
179
792
2.24
21.70
4.7
4.9
1.3
1.4
mmol/l
0.38
159
692
481
2957
1.66
21.41
3.6
3.3
5.8
5.8
kpa
0.27
456
2834
1193
8934
1.43
21.04
5.1
4.1
264.5
150.4
e6/l
1.02
885
6732
237
1197
1.98
20.30
4.4
4.2
0.9
0.9
%
2.56
224
1122
83
259
3.14
20.23
1.4
1.4
3.7
45.7
e6/l
1.18
64
210
83
260
3.13
20.10
1.6
1.4
1085.1
1063.2
e6/l
0.01
66
216
1019
7502
1.43
19.43
3.4
3.8
7.4
7.4
ph
0.25
163
1413
76
231
3.22
19.36
1.3
1.3
—
—
—
0
0
1036
7657
1.43
19.31
2.5
2.4
3.2
3.3
mg/l
0.31
835
6396
236
1211
1.94
19.31
4.3
4.1
1.6
1.5
%
1.12
223
1138
927
6716
1.44
19.26
1.8
1.7
18.0
19.6
nmol/l
2.13
830
5649
2339
19786
1.38
19.20
27.8
20.4
30.6
30.0
mg/l
0.38
2130
16904
1994
16464
1.37
18.89
30.0
22.3
35.1
36.5
%
4.47
1067
9238
113
433
2.57
18.88
1.5
1.9
27.2
32.7
umol/l
1.40
82
332
598
8041
0.66
18.02
2.0
2.4
—
—
—
0
0
1431
11343
1.36
16.97
13.7
12.9
1.5
1.5
inr
0.20
329
2994
1360
10717
1.36
16.68
3.5
3.0
61.1
58.8
u/l
0.32
1190
9493
1507
12100
1.34
16.19
4.3
5.5
12.8
13.2
umol/l
0.43
1389
11385
619
4275
1.48
16.17
3.8
3.3
3.2
2.2
e6/l
0.97
338
2476
285
4417
0.59
15.94
1.5
1.6
1.3
1.2
mmol/l
0.49
255
3608
120
513
2.30
15.85
3.1
2.6
—
—
—
0
0
121
520
2.29
15.79
3.1
2.5
4.2
4.2
mmol/l
0.04
121
514
121
520
2.29
15.79
3.1
2.5
106.1
105.4
mmol/l
0.56
121
514
130
576
2.22
15.77
1.3
1.2
—
—
—
0
0
1309
10370
1.34
15.09
5.4
4.8
178.5
68.5
ng/l
0.39
1028
8444
929
6980
1.38
15.07
4.3
3.5
—
—
—
0
0
2063
17440
1.32
15.05
4.9
4.7
2.0
2.1
mu/l
3.44
1820
15233
967
7345
1.37
14.59
4.3
3.6
0.5
0.6
e6/l
0.17
765
5737
240
1408
1.69
12.64
2.7
3.2
23.9
24.1
mmol/l
0.37
219
1251
926
7121
1.34
12.58
2.6
2.4
55.5
60.0
u/l
1.58
854
6501
1067
8378
1.32
12.55
5.3
4.2
—
5.9
—
0
9
241
1419
1.69
12.52
2.8
2.4
1.1
1.1
%
0.23
241
1411
459
3137
1.47
12.45
4.0
3.3
367.4
339.6
ng/l
0.49
427
2848
1961
16732
1.28
12.07
6.6
7.2
85.0
85.4
u/l
0.10
1793
15466
63
227
2.71
12.02
3.5
3.3
—
—
—
0
0
770
5797
1.36
11.95
3.4
2.8
5.4
4.9
e6/l
0.69
682
5090
2361
20673
1.28
11.56
32.4
25.0
139.3
139.2
mmol/l
0.65
2252
19970
2362
20693
1.28
11.46
32.5
25.2
4.0
4.0
mmol/l
6.10
2242
19960
264
1635
1.60
11.24
1.8
1.9
394.2
392.5
nmol/l
0.04
232
1449
2368
20820
1.27
10.79
36.6
29.7
7.6
7.2
e9/l
5.82
2231
19867
2368
20820
1.27
10.79
36.9
29.9
124.9
128.3
g/l
22.59
2265
20237
2367
20812
1.27
10.78
36.7
29.7
233.5
232.2
e9/l
0.36
2243
19965
2367
20814
1.27
10.76
36.5
29.6
30.3
30.4
pg
2.18
2260
20208
2367
20815
1.27
10.75
36.6
29.7
4.2
4.3
e12/l
14.20
2221
19868
2367
20815
1.27
10.75
36.5
29.6
91.9
92.1
fl
1.08
2259
20212
283
1806
1.56
10.60
5.3
5.7
24.9
24.5
mmol/l
1.00
265
1689
569
4155
1.38
10.59
1.7
1.8
30.1
30.6
s
1.00
549
3996
146
786
1.83
10.40
5.0
3.7
8.1
8.0
mmol/l
0.19
146
776
25
54
4.50
10.39
1.4
1.2
—
—
—
0
0
173
980
1.74
10.38
7.5
5.0
—
—
—
0
0
470
3336
1.41
10.32
4.5
5.4
1.7
1.1
mmol/l
2.31
348
2503
411
2850
1.44
10.27
1.8
1.8
—
—
—
0
0
606
4509
1.36
9.98
3.6
3.1
1.3
1.4
e6/l
0.37
324
2689
1662
14099
1.25
9.95
3.6
3.8
15.2
15.3
pmol/l
0.78
1441
12252
466
3340
1.40
9.65
4.5
5.4
5.0
5.0
kpa
0.07
416
3097
148
819
1.78
9.65
4.9
3.6
1.6
1.7
mmol/l
1.14
148
810
466
3341
1.40
9.64
4.5
5.4
10.8
11.4
kpa
1.76
413
3093
1761
15094
1.24
9.41
32.4
24.8
14.4
14.2
%
6.01
1683
14613
107
1884
0.54
9.39
1.2
1.3
—
—
—
0
0
1264
10450
1.26
9.31
5.7
4.4
0.0
0.0
estimate
0.00
188
1975
1271
10580
1.24
8.65
6.0
4.5
0.0
0.0
estimate
0.00
184
1941
248
1615
1.52
8.50
4.4
3.4
25.6
25.0
mmol/l
2.04
240
1564
295
1993
1.47
8.44
3.8
3.7
—
—
—
0
0
2222
19651
1.23
8.41
25.9
19.8
—
—
—
0
0
33
103
3.11
8.22
1.4
1.3
—
—
—
0
0
732
5756
1.28
7.99
3.5
3.9
75.8
78.1
%
1.60
705
5599
353
2491
1.41
7.98
2.1
2.4
10.7
10.8
umol/l
0.02
273
2142
25
67
3.62
7.88
2.5
2.0
59.4
56.0
umol/l
0.20
18
48
68
310
2.14
7.87
4.9
5.4
13.3
12.8
mg/l
0.32
59
272
621
4789
1.30
7.85
32.9
34.5
1.8
1.6
inr
1.04
87
611
1245
10428
1.23
7.81
8.5
6.1
0.0
0.0
estimate
0.00
188
1948
213
1371
1.53
7.73
6.2
7.6
—
—
—
0
0
163
998
1.60
7.36
2.3
2.1
1135.4
560.1
ug/l
0.66
143
946
104
570
1.78
7.10
1.6
2.1
—
—
—
0
0
307
2160
1.41
7.07
3.1
3.4
103.7
103.8
ng/l
0.01
230
1785
198
2791
0.67
7.04
1.3
1.4
—
—
—
0
0
394
2917
1.34
6.62
4.9
5.7
94.2
95.0
%
0.95
364
2779
156
2275
0.65
6.55
1.2
1.2
4.7
16.7
u/ml
2.87
33
725
517
4000
1.29
6.31
2.1
2.5
0.8
0.8
mmol/l
0.24
434
3613
601
7036
0.79
6.28
3.0
3.2
839.7
274.8
mg/l
1.42
422
4586
504
3890
1.29
6.27
2.1
2.2
1.7
1.8
%
0.13
394
3336
340
4274
0.75
6.15
3.8
3.6
—
—
—
0
0
21
60
3.39
6.07
3.0
2.8
29.7
29.2
umol/l
0.06
13
43
604
7041
0.80
6.06
2.8
3.1
6.7
6.6
mmol/l
0.43
471
5588
194
1298
1.47
5.90
1.9
1.8
3.1
2.3
ug/l
0.38
146
1088
1188
10126
1.20
5.84
5.1
5.4
22.7
23.9
%
2.61
1055
9178
383
2889
1.31
5.65
2.5
2.6
4.4
5.8
ug/l
2.29
266
2381
1720
15175
1.18
5.58
3.9
4.2
18.3
17.1
mm/h
1.67
1516
13660
660
5338
1.24
5.50
6.6
4.4
—
—
—
0
0
344
2567
1.32
5.49
5.3
6.1
118.8
117.9
g/l
0.36
331
2474
286
2077
1.36
5.47
2.3
2.4
28.9
35.6
u/l
2.80
236
1738
324
2408
1.33
5.32
4.6
6.0
—
—
—
0
0
62
319
1.89
5.27
2.8
2.3
4.2
2.3
u/field
0.67
20
93
897
7512
1.20
5.25
2.3
2.7
—
—
—
0
0
86
1358
0.60
5.17
1.3
1.4
—
—
—
0
0
1156
9920
1.18
5.12
5.0
5.2
61.8
60.5
%
2.70
1037
9055
1132
9702
1.18
5.08
4.5
5.1
0.5
0.6
%
1.77
1020
8846
461
3611
1.27
5.08
4.4
4.6
1.0
1.1
mmol/l
0.12
388
3248
10
18
5.38
5.08
1.4
1.2
—
—
—
0
0
183
2461
0.70
5.07
1.2
1.2
46.1
42.3
iu/ml
0.11
58
752
1064
9084
1.18
4.98
3.0
2.9
135.4
156.6
ug/l
2.49
923
8059
36
155
2.26
4.92
3.3
1.9
2.0
2.4
u/field
0.20
20
98
136
882
1.51
4.88
4.7
3.8
—
—
—
0
0
215
1521
1.39
4.87
7.0
4.3
—
—
—
0
0
216
1536
1.38
4.75
3.7
2.9
0.3
0.4
e6/l
0.89
210
1512
29
116
2.43
4.67
1.4
1.3
—
—
—
0
0
1156
9984
1.17
4.65
5.2
5.5
8.9
9.1
%
1.02
1038
9106
1151
9941
1.17
4.62
4.8
5.2
2.8
2.8
%
0.02
1031
9054
22
77
2.77
4.60
1.0
1.0
124.1
136.2
nmol/l
0.71
22
77
673
7557
0.83
4.54
3.5
3.9
15.7
10.6
mg/mmol
1.44
445
4858
2222
20185
1.16
4.51
10.4
11.1
22.7
22.9
u/l
0.09
2077
19056
440
3481
1.25
4.46
5.0
5.6
104.6
104.1
mmol/l
1.06
427
3398
328
2507
1.29
4.42
3.9
5.1
1.6
1.5
mmol/l
0.78
305
2346
577
4710
1.22
4.35
6.4
5.0
1.0
1.0
kg/l
0.29
115
800
1379
12135
1.16
4.26
5.8
7.5
5.0
4.6
e9/l
5.00
1109
10294
1217
10614
1.16
4.24
4.7
5.0
1.8
1.8
e9/l
0.10
982
8983
14
39
3.48
4.24
6.5
2.7
0.3
0.4
u/field
0.41
14
39
290
2194
1.30
4.23
1.6
1.9
0.2
0.2
g/l
2.48
246
1981
15
45
3.23
4.07
1.4
1.2
—
—
—
0
0
569
4680
1.21
3.96
2.3
2.4
10.3
11.2
umol/l
2.63
492
4234
19
69
2.67
3.75
1.4
1.4
—
—
—
0
0
1192
10461
1.15
3.71
4.5
4.9
0.0
0.0
e9/l
0.15
967
8694
9
260
0.33
3.68
1.1
1.2
—
—
—
0
0
120
1636
0.70
3.67
2.7
3.6
1.1
0.6
%
0.49
22
395
47
251
1.82
3.67
1.5
1.3
282.5
273.7
mosm/kgh2o
0.92
26
169
122
827
1.44
3.60
2.5
2.8
4.2
4.2
pmol/l
0.19
88
697
870
7478
1.16
3.59
4.0
4.9
—
—
—
0
0
1221
10753
1.14
3.59
4.6
5.0
0.2
0.2
e9/l
0.23
989
9052
92
592
1.51
3.53
1.4
1.3
57.0
59.6
mmol/l
0.30
74
471
1180
10381
1.14
3.51
4.4
4.9
0.7
0.6
e9/l
2.20
953
8606
34
166
1.99
3.47
1.5
1.4
9.6
10.0
%
0.22
34
166
95
1337
0.68
3.47
1.6
1.6
—
—
—
0
0
22
90
2.37
3.44
1.2
1.2
0.9
1.2
promille
0.43
16
69
219
2692
0.77
3.39
1.2
1.2
—
—
—
0
0
32
156
1.99
3.29
1.3
1.1
—
—
—
0
0
33
589
0.54
3.24
1.2
1.1
—
—
—
0
0
189
1404
1.32
3.22
1.4
1.4
—
—
—
0
0
135
1761
0.73
3.20
2.7
3.6
0.1
0.1
%
0.23
37
545
57
336
1.65
3.19
1.2
1.2
—
—
—
0
0
525
4387
1.18
3.07
2.3
2.4
2.2
2.2
g/l
1.85
456
3973
7
206
0.33
3.06
1.4
1.2
—
—
—
0
0
146
1854
0.75
2.91
2.7
3.6
1.3
0.9
%
0.55
41
591
122
1590
0.73
2.90
2.6
3.7
0.2
0.3
%
0.24
27
435
38
206
1.79
2.89
1.1
1.2
33.9
34.7
mmol/l
0.07
27
168
78
1095
0.68
2.87
1.1
1.2
—
—
—
0
0
62
385
1.57
2.85
10.7
10.5
6.8
7.3
mmol/l
0.91
49
314
496
4151
1.18
2.85
2.4
2.5
19.3
20.3
%
0.94
361
3473
606
5157
1.16
2.82
4.9
4.3
—
—
—
0
0
160
1186
1.32
2.81
1.4
1.4
—
—
—
0
0
102
1358
0.72
2.79
1.6
1.5
—
—
—
0
0
11
35
3.04
2.76
1.4
1.2
—
—
—
0
0
428
3550
1.19
2.74
2.2
1.9
—
—
—
0
0
45
261
1.67
2.73
1.4
1.3
277.2
304.4
nmol/l
0.35
30
193
12
42
2.77
2.58
1.1
1.2
—
—
—
0
0
161
1981
0.78
2.57
1.2
1.3
—
—
—
0
0
144
1067
1.32
2.56
3.8
3.1
0.8
0.8
nmol/l
0.49
107
818
9
220
0.39
2.54
1.8
2.7
14.2
11.0
nmol/l
—
9
211
61
874
0.67
2.53
2.9
2.1
—
—
—
0
0
11
37
2.88
2.53
1.4
1.2
—
—
—
0
0
11
37
2.88
2.53
1.4
1.2
—
—
—
0
0
11
37
2.88
2.53
1.4
1.2
—
—
—
0
0
252
2937
0.82
2.50
2.4
3.6
13.5
22.4
ug/l
0.42
207
2470
30
160
1.82
2.45
4.2
3.3
—
—
—
0
0
100
708
1.37
2.42
1.2
1.4
—
—
—
0
0
48
706
0.65
2.30
2.6
3.4
113.0
112.8
u/ml
0.00
48
672
5
151
0.32
2.27
1.0
1.1
—
54.9
—
0
6
17
76
2.17
2.25
1.2
1.3
122.2
81.2
umol/l
—
5
46
87
1140
0.73
2.22
1.9
2.1
8.9
10.1
nmol/l
0.52
68
952
139
1055
1.28
2.12
1.2
1.2
—
—
—
0
0
82
576
1.38
2.12
1.3
1.2
—
—
—
0
0
75
995
0.72
2.09
1.4
1.2
—
—
—
0
0
9
30
2.90
2.06
1.4
1.2
—
—
—
0
0
46
291
1.53
2.04
2.0
2.0
—
—
—
0
0
1115
10052
1.10
1.99
4.2
4.6
—
—
—
0
0
21
364
0.55
1.99
1.1
1.6
16.9
23.2
ug/l
0.90
21
352
112
836
1.30
1.96
2.4
3.3
25.3
24.9
mmol/l
0.37
102
720
34
517
0.63
1.94
3.8
2.4
—
—
—
0
0
10
38
2.55
1.88
3.3
2.4
31.2
39.2
umol/l
—
10
29
10
38
2.55
1.88
1.4
1.2
—
—
—
0
0
32
193
1.61
1.77
15.9
18.2
—
—
—
0
0
13
249
0.50
1.73
1.8
1.4
82.4
297.0
pmol/l
2.71
13
240
84
616
1.32
1.71
1.6
1.5
243.5
258.7
ug/g
0.30
48
391
1105
10024
1.09
1.70
3.2
3.5
2555.7
2580.0
ng/l
0.05
918
8740
17
291
0.56
1.59
3.1
3.7
66.4
61.5
%
—
8
167
13
61
2.06
1.58
1.2
1.3
—
—
—
0
0
90
676
1.29
1.57
4.7
4.6
2.7
3.0
mmol/l
0.40
68
451
1740
17498
0.93
1.56
3.8
4.6
1.4
1.4
mmol/l
6.66
1505
15238
10
42
2.30
1.56
1.4
1.3
—
17.9
%
—
0
7
53
368
1.40
1.54
1.5
1.4
—
—
—
0
0
21
336
0.60
1.54
1.4
1.3
—
—
—
0
0
261
2192
1.16
1.53
2.1
2.2
—
—
—
0
0
0
40
0.00
1.53
0.0
1.0
—
—
—
0
0
0
44
0.00
1.49
0.0
1.6
—
—
—
0
0
27
403
0.64
1.48
1.0
1.1
—
—
—
0
0
308
2625
1.15
1.48
4.8
5.3
12.9
13.3
mmol/l
0.28
270
2427
8
164
0.47
1.46
1.0
1.1
—
—
—
0
0
11
50
2.13
1.45
1.2
1.2
—
—
—
0
0
169
1924
0.84
1.41
1.2
1.3
590.0
511.6
titre
0.20
36
442
11
205
0.52
1.39
1.0
1.1
—
—
—
0
0
152
1235
1.20
1.35
1.4
1.4
—
—
—
0
0
22
131
1.63
1.33
2.6
2.5
—
—
—
0
0
92
711
1.26
1.32
3.5
3.8
—
—
—
0
0
1773
17740
0.93
1.30
3.9
4.6
4.0
4.2
mmol/l
14.96
1541
15644
12
212
0.55
1.30
1.1
1.2
—
—
—
0
0
359
3846
0.89
1.30
4.1
4.3
—
—
—
0
0
45
315
1.38
1.29
1.3
1.5
3.0
4.9
iu/l
—
9
82
32
446
0.69
1.29
2.4
2.7
—
—
—
0
0
186
1546
1.17
1.28
4.8
6.7
24.7
24.3
mmol/l
0.67
152
1380
45
316
1.38
1.27
4.3
3.4
—
—
—
0
0
1691
16936
0.94
1.26
3.5
4.1
1.2
1.2
mmol/l
0.20
1446
14575
12
60
1.94
1.26
1.1
1.2
—
—
—
0
0
98
768
1.24
1.26
5.1
4.4
7.4
7.4
ph
0.58
87
659
333
2888
1.13
1.26
2.3
2.3
64.2
66.3
e9/l
0.55
250
2215
13
68
1.85
1.21
2.8
1.7
—
—
—
0
0
74
565
1.27
1.20
1.6
1.5
19138.1
19427.4
e6/l
0.02
51
402
49
354
1.34
1.18
1.2
1.2
—
—
—
0
0
143
1617
0.85
1.15
1.7
1.8
286.8
172.4
ug/g
1.45
115
1221
5
20
2.42
1.10
1.4
1.0
—
—
—
0
0
81
955
0.82
1.04
1.9
2.6
108.1
4723.4
u/ml
0.99
66
807
301
2629
1.12
1.04
2.2
2.3
64.8
65.5
g/l
0.75
241
2291
8
144
0.54
1.03
1.4
1.2
—
—
—
0
0
143
1191
1.17
1.01
2.3
2.1
10.2
10.6
g/l
0.31
98
972
216
1855
1.13
1.00
3.2
3.8
7.4
7.4
ph
0.17
27
232
427
4465
0.91
1.00
1.2
1.3
—
—
—
0
0
1917
18014
1.06
0.98
7.0
7.0
43.9
42.0
mmol/mol
8.49
1692
15998
23
152
1.46
0.94
2.4
3.4
8.4
7.5
mmol/l
0.65
18
100
6
115
0.50
0.93
1.0
1.1
—
—
—
0
0
1004
9269
1.06
0.93
4.5
5.8
6.2
6.0
ug/l
0.02
826
8065
620
5631
1.08
0.93
2.1
2.6
—
—
—
0
0
250
2178
1.12
0.93
3.8
3.7
1.2
1.2
mmol/l
0.13
218
1872
19
121
1.52
0.92
1.3
1.2
—
3.0
—
0
7
12
68
1.71
0.90
1.1
1.0
215.3
284.3
mg/l
1.53
12
58
104
855
1.18
0.89
3.5
3.6
4.0
3.9
mmol/l
0.81
94
789
13
76
1.65
0.88
1.6
1.5
—
—
—
0
0
10
54
1.79
0.87
1.2
1.5
16.3
15.9
pmol/l
—
10
42
22
301
0.70
0.87
1.5
1.4
—
—
—
0
0
6
29
2.00
0.86
1.0
1.0
2543.2
1501.8
miu/ml
—
6
29
26
345
0.73
0.86
1.2
1.2
—
—
—
0
0
584
5310
1.07
0.86
4.7
6.0
—
—
—
0
0
17
242
0.68
0.83
1.1
1.2
—
—
—
0
0
511
5255
0.93
0.82
2.9
3.4
0.8
0.9
ug/l
2.19
361
3869
189
1635
1.12
0.82
5.8
3.6
—
—
—
0
0
28
199
1.36
0.81
1.0
1.1
—
—
—
0
0
194
1684
1.12
0.80
1.5
1.6
1.5
1.5
g/l
0.09
156
1420
90
740
1.18
0.79
2.2
3.0
7.4
7.6
kpa
0.62
83
681
31
225
1.33
0.79
1.8
2.2
691.3
607.8
ml
0.38
19
131
58
682
0.82
0.78
1.3
1.2
185.6
211.5
u/ml
0.23
50
608
12
180
0.64
0.77
1.1
1.1
—
—
—
0
0
112
941
1.15
0.76
2.3
2.7
0.5
0.3
g/l
0.68
34
368
78
638
1.19
0.74
2.3
3.0
—
—
—
0
0
31
389
0.77
0.74
3.8
2.8
—
—
—
0
0
41
496
0.80
0.73
1.3
1.4
—
—
—
0
0
148
1273
1.13
0.73
3.6
3.4
4.3
4.3
e9/l
0.04
97
825
624
5725
1.06
0.72
6.5
4.9
0.0
0.0
estimate
0.50
160
1813
115
973
1.15
0.72
1.9
2.1
35.9
36.2
g/l
0.21
80
788
214
1885
1.10
0.70
3.3
3.8
5.3
5.2
kpa
0.74
179
1703
75
616
1.18
0.69
4.7
3.9
28.8
32.9
mg/l
0.51
60
427
28
205
1.32
0.69
1.2
1.4
0.7
1.0
g/l
1.30
23
152
42
326
1.25
0.68
1.1
1.3
—
—
—
0
0
18
123
1.42
0.67
1.3
1.2
0.3
0.5
g/l
1.33
13
89
18
123
1.42
0.67
1.3
1.2
7.0
7.7
g/l
0.26
13
87
18
123
1.42
0.67
1.3
1.2
2.7
2.8
g/l
0.07
13
90
5
27
1.79
0.66
1.2
1.3
—
—
—
0
0
41
319
1.24
0.65
1.3
1.2
0.7
0.8
nmol/l
0.16
31
256
39
466
0.81
0.64
2.9
3.8
1.5
1.5
%
0.01
25
335
24
174
1.33
0.64
1.1
1.4
—
—
—
0
0
5
28
1.73
0.64
2.8
8.1
—
—
—
0
0
13
84
1.50
0.63
2.1
2.6
35.2
34.3
%
—
6
34
92
777
1.15
0.62
1.3
1.2
—
—
—
0
0
126
1087
1.12
0.62
2.0
2.8
1.7
3.6
ratio
—
7
81
282
2926
0.93
0.61
14.7
10.0
—
—
—
0
0
0
19
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.8
—
—
—
0
0
18
126
1.38
0.60
1.3
1.2
—
—
—
0
0
0
21
0.00
0.59
0.0
1.1
—
1.7
—
0
21
24
177
1.31
0.59
1.2
1.5
—
—
—
0
0
98
836
1.14
0.58
2.0
2.8
—
—
—
0
0
8
51
1.52
0.58
3.0
2.1
—
—
—
0
0
128
1111
1.12
0.58
2.0
2.8
61.6
117.8
mg/l
0.56
102
907
13
178
0.70
0.57
1.5
2.2
—
—
—
0
0
15
103
1.41
0.56
2.5
3.9
54.8
55.7
%
0.06
15
93
18
232
0.75
0.55
1.0
1.1
—
—
—
0
0
28
214
1.27
0.54
1.2
1.4
—
—
—
0
0
28
214
1.27
0.54
1.2
1.4
—
—
—
0
0
28
214
1.27
0.54
1.2
1.4
—
—
—
0
0
28
214
1.27
0.54
1.2
1.4
—
—
—
0
0
6
37
1.57
0.54
2.0
1.6
—
—
—
0
0
9
128
0.68
0.52
1.6
1.5
11.0
17.8
%
—
9
110
9
131
0.66
0.51
4.7
4.3
—
—
—
0
0
24
292
0.79
0.50
1.1
1.2
—
—
—
0
0
22
165
1.29
0.50
1.3
1.2
—
—
—
0
0
61
677
0.87
0.49
1.1
1.1
63.9
101.7
iu/ml
0.63
14
211
491
4536
1.05
0.49
1.7
1.6
1.5
1.7
mg/l
0.96
394
3547
126
1109
1.10
0.47
2.0
2.8
52.9
62.3
mg/l
0.20
99
911
5
81
0.60
0.45
1.2
1.2
—
—
—
0
0
81
703
1.12
0.41
2.0
2.4
124.9
122.9
g/l
0.24
65
504
114
1008
1.10
0.41
1.4
1.3
—
—
—
0
0
5
33
1.46
0.40
1.0
1.5
—
—
—
0
0
46
511
0.87
0.40
1.3
1.4
104624.7
75362.3
e6/l
0.18
30
307
27
215
1.21
0.40
1.0
1.1
—
—
—
0
0
339
3124
1.05
0.39
1.2
1.2
2.8
1.5
u/ml
0.49
63
730
7
100
0.68
0.39
1.9
2.2
—
—
—
0
0
1885
18472
0.97
0.39
4.5
5.3
2.2
2.4
mmol/l
16.73
1670
16196
142
1274
1.08
0.38
2.3
2.6
11.3
11.1
g/l
0.15
122
1135
1952
18605
1.03
0.37
4.6
5.3
6.3
6.2
mmol/l
2.95
1669
16082
13
164
0.76
0.37
1.2
1.2
—
—
—
0
0
13
164
0.76
0.37
1.2
1.1
—
43.8
—
0
9
9
66
1.32
0.37
1.4
1.2
258.6
223.1
iu/ml
—
9
66
26
301
0.83
0.37
2.7
4.3
—
—
—
0
0
11
78
1.36
0.36
4.5
5.3
—
—
—
0
0
29
236
1.19
0.36
1.2
1.4
503.3
250.4
titre
—
6
25
173
1569
1.07
0.35
2.6
2.6
—
—
—
0
0
109
1141
0.92
0.35
5.0
4.1
—
—
—
0
0
5
78
0.62
0.35
1.0
1.0
—
—
—
0
0
9
121
0.72
0.35
4.7
4.5
—
—
—
0
0
9
122
0.71
0.35
1.0
1.0
—
—
—
0
0
163
1677
0.94
0.34
6.0
7.0
91.4
93.7
%
1.91
163
1667
10
129
0.75
0.34
1.2
1.1
—
134.0
—
0
5
42
462
0.88
0.33
1.4
1.6
16.5
13.8
mg/l
0.74
37
415
6
85
0.68
0.33
1.7
1.8
—
—
—
0
0
27
221
1.18
0.32
1.0
1.0
—
—
—
0
0
739
7321
0.97
0.32
5.6
4.9
—
—
—
0
0
39
429
0.88
0.32
1.5
1.5
—
—
—
0
0
12
89
1.30
0.31
1.7
1.7
17.6
18.4
%
—
7
35
7
51
1.33
0.31
1.3
1.3
—
—
—
0
0
902
8898
0.97
0.30
10.5
10.8
0.0
0.0
e9/l
0.36
671
7079
25
281
0.86
0.28
1.9
2.7
—
—
—
0
0
8
63
1.23
0.27
1.4
1.2
—
—
—
0
0
5
72
0.67
0.26
1.0
1.0
—
—
—
0
0
209
2109
0.95
0.25
1.4
1.4
—
—
—
0
0
10
76
1.27
0.23
1.2
1.7
0.7
0.8
mmol/l
—
10
69
17
193
0.85
0.22
1.1
1.2
264.1
237.3
pmol/l
0.11
12
148
5
39
1.24
0.22
1.2
1.1
—
—
—
0
0
24
264
0.88
0.21
1.1
1.1
—
—
—
0
0
50
443
1.09
0.21
1.5
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
18
202
0.86
0.21
1.1
1.3
—
—
—
0
0
0
13
0.00
0.20
0.0
1.2
—
—
—
0
0
0
13
0.00
0.20
0.0
1.8
—
—
—
0
0
276
2584
1.03
0.20
5.3
4.8
—
—
—
0
0
142
1311
1.05
0.20
3.4
3.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
1.1
—
0
5
14
160
0.84
0.20
3.3
2.5
—
—
—
0
0
69
623
1.07
0.20
15.7
13.6
—
—
—
0
0
112
1031
1.05
0.18
1.3
1.8
1.1
1.5
g/l
1.61
97
904
16
179
0.86
0.18
1.4
2.1
—
—
—
0
0
617
6068
0.98
0.18
2.6
3.0
4070.6
8704.5
umol/l
2.03
492
4950
10
117
0.83
0.18
1.2
1.2
—
—
—
0
0
22
188
1.13
0.17
1.6
1.1
—
—
—
0
0
7
60
1.13
0.17
1.3
2.6
13.5
14.3
ml/dl
—
7
55
6
76
0.76
0.15
2.7
1.9
—
—
—
0
0
10
115
0.84
0.15
1.2
1.4
1547.4
1669.6
ml
—
5
45
33
346
0.92
0.14
1.7
2.3
—
—
—
0
0
7
83
0.81
0.14
1.1
1.1
—
—
—
0
0
7
85
0.80
0.14
2.3
2.2
—
—
—
0
0
17
145
1.13
0.14
1.1
1.1
1.8
5.0
u/ml
—
5
73
11
124
0.86
0.14
1.2
1.3
2.4
3.4
mmol/l
1.73
11
109
1506
14442
1.01
0.13
4.6
4.7
—
—
—
0
0
142
1328
1.03
0.13
2.7
3.0
—
—
—
0
0
12
133
0.87
0.12
1.4
1.4
—
—
—
0
0
54
550
0.95
0.12
1.8
1.6
—
—
—
0
0
64
646
0.96
0.10
1.8
2.3
296.8
99.8
ug/min
0.77
31
381
229
2167
1.02
0.10
4.3
3.8
—
—
—
0
0
44
448
0.95
0.10
1.3
1.2
26.4
55.2
u/l
1.51
37
383
5
44
1.10
0.09
1.6
1.6
88.4
122.8
ng/l
—
5
44
52
480
1.05
0.09
1.3
1.5
—
—
—
0
0
96
899
1.03
0.09
2.3
2.5
—
15.9
—
0
17
54
545
0.96
0.09
1.3
1.5
2790.2
1407.2
e6/l
0.48
35
396
6
55
1.05
0.08
1.2
1.1
—
—
—
0
0
60
558
1.04
0.08
1.7
2.5
2.0
1.9
mg/l
0.17
48
476
20
208
0.93
0.08
1.1
1.3
119.3
119.0
u/ml
—
6
37
22
198
1.07
0.08
1.0
1.1
342.0
330.5
u/ml
0.04
11
114
24
217
1.07
0.07
1.3
1.2
26303.2
205480.8
e6/l
2.09
11
149
48
483
0.96
0.07
1.4
1.6
—
—
—
0
0
8
76
1.02
0.07
1.4
1.6
107.3
107.6
ug/l
—
8
66
7
80
0.85
0.07
1.0
1.0
—
—
—
0
0
7
80
0.85
0.07
1.3
1.6
0.1
0.6
e9/l
—
7
74
18
187
0.93
0.06
1.7
1.4
—
—
—
0
0
8
87
0.89
0.06
2.3
3.0
—
—
—
0
0
24
245
0.95
0.06
1.1
1.2
—
—
—
0
0
191
1871
0.99
0.05
6.3
4.8
—
—
—
0
0
67
664
0.97
0.05
2.8
2.6
15.6
15.2
%
0.31
32
346
63
624
0.97
0.05
1.3
1.5
28.3
29.5
g/l
0.37
55
538
41
408
0.97
0.04
3.5
3.2
64.1
61.5
%
0.55
41
408
111
1087
0.99
0.03
4.1
4.2
25.0
24.7
mmol/l
0.37
82
975
17
173
0.95
0.03
1.4
1.5
79.2
69.0
%
—
9
136
19
192
0.96
0.02
1.1
1.3
—
—
nmol/l
—
0
0
32
300
1.03
0.02
1.4
1.9
—
—
—
0
0
15
137
1.06
0.02
1.1
1.2
—
31.9
—
0
7
13
132
0.95
0.01
2.0
1.3
—
—
—
0
0
48
457
1.01
0.01
1.3
1.3
1.2
1.1
g/l
0.60
42
426
26
257
0.98
0.00
1.3
1.6
—
—
—
0
0
10
93
1.04
0.00
1.2
1.1
37.4
40.1
g/l
—
5
40
10
93
1.04
0.00
1.3
1.4
—
—
—
0
0
46
447
0.99
0.00
1.3
1.3
0.3
0.2
g/l
1.13
40
419
25
238
1.01
0.00
1.1
1.3
—
—
—
0
0
291
2807
1.00
0.00
1.4
1.4
3.3
2.8
g/l
1.07
146
1526
14
132
1.02
0.00
1.6
1.4
—
—
—
0
0
29
279
1.00
0.00
1.5
1.4
67.1
67.8
%
0.04
22
183
20
197
0.98
0.00
1.6
1.4
—
—
—
0
0
5
54
0.89
0.00
1.8
1.3
20.3
31.1
g/l
—
5
41
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
280.2
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0
9
92
0.94
0.00
1.3
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
209.1
—
0
8

Mortality – FinRegistry

Association

Association between endpoint F5_VASCDEM and mortality.

Females

Parameter HR [95% CI] p-value
F5_VASCDEM 2.669 [2.37, 3.01] < 0.001
Birth year 0.995 [0.99, 1.0] 0.188

During the follow-up period (1.1.1998 — 31.12.2019), 15971 out of 21397 females with F5_VASCDEM died.

Males

Parameter HR [95% CI] p-value
F5_VASCDEM 3.066 [2.63, 3.58] < 0.001
Birth year 0.989 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 11786 out of 15677 males with F5_VASCDEM died.

Mortality risk

Mortality risk for people of age

years, who have F5_VASCDEM.

N-year risk Females Males
1 0.181% 0.66%
5 1.301% 3.649%
10 3.382% 8.705%
15 6.703% 15.866%
20 11.875% 26.392%

Relationships between endpoints

Index endpoint: F5_VASCDEM – Vascular dementia

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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