vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1691 |
4. Check minimum number of eventsNone |
1691 |
5. Include endpointsNone |
1691 |
6. Filter based on genotype QC (FinnGen only) |
1691 |
Control definitions (FinnGen only)
- Control exclude
- F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F01
- Name in latin
- Dementia vascularis non specificata
Similar endpoints
↥List of similar endpoints to
Vascular dementia (undefined)
based on the number of shared cases.
Similar with more cases:
- Vascular dementia
- Any dementia
- Any dementia, excluding more controls
- Dementia
- Dementia, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 32388 | 19286 | 12580 |
| Only index persons | 20944 | 12781 | 8163 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.47 | 0.55 | 0.35 |
| Only index persons | 0.41 | 0.47 | 0.31 |
| Median age at first event (years) | |||
| Whole population | 84.37 | 85.85 | 82.22 |
| Only index persons | 85.25 | 86.78 | 82.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1691 | 622 | 1069 |
| Unadjusted period prevalence (%) | 0.38 | 0.21 | 0.47 |
| Median age at first event (years) | 82.41 | 84.28 | 81.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1468
- Matched controls
- 14573
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F03
ICD-10 Finland
Unspecified dementia
62.9
323.0
392
84
F01.9
ICD-10 Finland
Vascular dementia, unspecified
4503599627370496.0
323.0
1466
20
N05AX08
ATC
risperidone; systemic
13.1
198.5
375
373
N06DX01
ATC
memantine; oral
74.5
192.2
218
34
N06DA02
ATC
donepezil; oral
92.6
163.1
180
22
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
5.2
123.1
447
1123
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
122.3
116
*
N05AH04
ATC
quetiapine; oral
7.5
121.8
316
515
G30.1
ICD-10 Finland
Alzheimer disease with late onset
38.0
108.4
139
40
F01
ICD-10 Finland
Vascular dementia
119.5
94.0
101
9
R53
ICD-10 Finland
Malaise and fatigue
3.6
91.6
528
1961
F01.0
ICD-10 Finland
Vascular dementia of acute onset
+∞
86.1
82
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.4
79.8
481
1813
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
5.6
79.1
253
523
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
167.8
76.6
80
5
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
+∞
69.1
66
*
P20
ICPC
Memory disturbance
3.8
67.3
331
1040
N06DA03
ATC
rivastigmine; oral, transdermal
51.7
65.8
79
16
R41.0
ICD-10 Finland
Disorientation, unspecified
6.6
62.2
169
280
G30.8
ICD-10 Finland
Other Alzheimer disease
61.6
60.9
71
12
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
64.2
58.7
68
11
N06DA04
ATC
galantamine; oral
59.3
53.8
63
11
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
52.2
630
3454
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
49.3
690
4037
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
133.7
49.0
52
*
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
251.4
48.2
49
*
F05.1
ICD-10 Finland
Delirium superimposed on dementia
43.5
47.7
59
14
N06AB04
ATC
citalopram; systemic
2.7
46.1
377
1645
N05AD01
ATC
haloperidol; systemic
5.5
44.9
141
278
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.9
44.8
156
345
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
3.2
44.7
262
917
N03AG01
ATC
valproic acid; systemic, rectal
7.0
43.1
111
169
AA1AD
NOMESCO Finland
CT of head and brain
2.4
42.8
457
2297
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
32.1
40.2
53
17
N06AX11
ATC
mirtazapine; oral
2.3
39.2
437
2228
P70
ICPC
Dementia
11.7
38.3
72
64
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
37.5
422
2150
A06AD11
ATC
lactulose; oral
2.3
37.4
461
2455
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
37.0
36.9
47
13
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
10.8
36.4
71
68
A28
ICPC
Limited function/disability NOS
2.3
35.6
389
1947
SPAT1053
SPAT
Memory test
2.5
34.0
319
1472
N05BA04
ATC
oxazepam; oral
2.2
33.4
400
2080
F01.1
ICD-10 Finland
Multi-infarct dementia
+∞
32.3
31
*
N06AB10
ATC
escitalopram; oral
3.1
32.1
194
683
N05AD03
ATC
melperone; systemic
6.8
31.8
82
125
F01.2
ICD-10 Finland
Subcortical vascular dementia
53.8
31.3
37
7
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.3
31.2
335
1645
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
29.6
327
1623
F05.9
ICD-10 Finland
Delirium, unspecified
5.1
28.6
93
190
WYA20
NOMESCO Finland
Home visit
7.1
28.1
70
102
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
26.2
313
1601
SPAT1216
SPAT
Assessment of functional ability
2.2
26.0
300
1513
N05AH03
ATC
olanzapine; systemic
6.6
25.0
65
101
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
252.4
24.7
25
*
R41.3
ICD-10 Finland
Other amnesia
5.4
24.4
75
144
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.3
23.7
246
1174
N02BE01
ATC
paracetamol; systemic, rectal
1.8
23.6
1029
8242
L28
ICPC
Limited function/disability (L)
2.1
23.1
316
1705
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.2
23.1
126
412
E86
ICD-10 Finland
Volume depletion
3.9
23.1
97
257
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.4
23.0
221
1013
F01.39
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without information on additional symptoms
+∞
22.9
22
*
Z75.5
ICD-10 Finland
Holiday relief care
5.7
21.0
61
110
N05BA06
ATC
lorazepam; systemic, sublingual
3.0
20.2
120
416
F01.3
ICD-10 Finland
Mixed cortical and subcortical vascular dementia
201.1
19.5
20
*
N30.0
ICD-10 Finland
Acute cystitis
2.1
19.5
235
1192
S72.0
ICD-10 Finland
Fracture of neck of femur
2.5
19.1
157
662
G30
ICD-10 Finland
Alzheimer disease
55.4
18.9
22
*
R55
ICD-10 Finland
Syncope and collapse
2.1
18.8
235
1213
R42
ICD-10 Finland
Dizziness and giddiness
1.8
18.6
370
2271
N30.9
ICD-10 Finland
Cystitis, unspecified
2.7
18.6
132
511
130
Kela drug reimbursment
Malignant tumour
0.2
18.6
21
943
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.6
18.5
86
249
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.2
18.5
194
925
F06.7
ICD-10 Finland
Mild cognitive disorder
4.3
18.3
68
161
F01.30
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without additional symptoms
30.2
18.3
24
8
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.2
18.0
99
326
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.1
17.7
70
176
F0019, G301
ICD-10 Finland
NA
+∞
17.7
17
*
I95.1
ICD-10 Finland
Orthostatic hypotension
3.1
17.6
100
336
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
95.5
17.5
19
*
F01.24
ICD-10 Finland
Subcortical vascular dementia other additional symptoms of mixed type
+∞
16.6
16
*
W19
ICD-10 Finland
Unspecified fall
2.3
16.5
163
754
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.2
16.5
174
828
F01.80
ICD-10 Finland
Other specified vascular dementia without additional symptoms
90.5
16.5
18
*
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
5.5
16.0
47
87
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.7
16.0
365
2324
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
3.6
16.0
72
204
SPAT1360
SPAT
Extensive global examination
2.6
15.5
120
489
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.9
15.3
269
1570
S06.0
ICD-10 Finland
Concussion
2.3
15.2
143
645
B01AC07
ATC
dipyridamole; systemic
1.9
15.1
228
1260
R33
ICD-10 Finland
Retention of urine
2.0
15.0
205
1088
I64
ICD-10 Finland
Stroke, not specified as haemorrhage or infarction
5.1
15.0
47
94
S70.0
ICD-10 Finland
Contusion of hip
2.8
15.0
96
350
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.8
14.8
100
377
J01DB01
ATC
cefalexin; oral
1.6
14.8
857
6915
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.5
14.7
122
516
H02AB02
ATC
dexamethasone; systemic
0.2
14.6
11
635
F009, G309
ICD-10 Finland
NA
+∞
14.6
14
*
SPAT1254
SPAT
Administration of medicine
1.8
14.5
256
1497
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
14.4
895
7321
SPAT1234
SPAT
Support of social functional capacity
2.5
14.4
114
472
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
2.8
14.3
96
361
N02AA05
ATC
oxycodone; systemic
1.8
14.2
278
1679
S01.0
ICD-10 Finland
Open wound of scalp
2.3
14.2
134
605
N06AX16
ATC
venlafaxine; oral
3.0
13.7
83
290
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
13.7
444
3096
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
5.3
13.7
41
78
G30.0
ICD-10 Finland
Alzheimer disease with early onset
+∞
13.5
13
*
F02.39*G20
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
+∞
13.5
13
*
F0029, G308
ICD-10 Finland
NA
+∞
13.5
13
*
K90
ICPC
Stroke/cerebrovascular accident
3.2
13.5
72
233
Z02.4
ICD-10 Finland
Examination for driving licence
0.5
13.3
106
2008
C10AA01
ATC
simvastatin; oral
1.5
13.3
705
5519
A10AE04
ATC
insulin glargine; parenteral
2.2
13.2
144
696
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
13.0
229
1333
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
5.4
12.8
38
72
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.3
12.8
125
575
4378A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Other[MULTI-INFARKTIDEMENTIA]
+∞
12.5
12
*
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
12.4
255
1559
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
130.1
12.4
13
*
XA800
NOMESCO Finland
Neuropsychological investigation
5.8
12.3
34
59
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
2.2
12.2
131
628
E000001
ATC
NA
1.8
12.1
244
1484
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.7
12.1
80
300
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.9
12.0
184
1018
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
11.8
219
1297
Z3231
NOMESCO Finland
Registered nurse
1.6
11.7
356
2423
K91
ICPC
Cerebrovascular disease
4.9
11.7
37
76
N06AX26
ATC
vortioxetine; oral
4.1
11.5
44
109
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.8
11.5
75
277
2900A
ICD-9 Finland
Senile and presenile organic psychotic conditions, Senile dementia, uncomplicated
+∞
11.4
11
*
J01CA08
ATC
pivmecillinam; oral
1.5
11.4
459
3345
F29
ICD-10 Finland
Unspecified nonorganic psychosis
7.5
11.4
26
35
A04
ICPC
Weakness/tiredness general
1.8
11.3
196
1133
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
7.9
11.3
25
32
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
17.1
11.2
17
10
U04
ICPC
Incontinence urine
2.5
10.8
82
331
Z2445
NOMESCO Finland
Psychologist
6.5
10.7
27
42
J01EA01
ATC
trimethoprim; systemic
1.5
10.7
417
3005
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.0
10.7
59
198
F05.8
ICD-10 Finland
Other delirium
6.3
10.6
27
43
I69.8
ICD-10 Finland
Sequelae of other and unspecified cerebrovascular diseases
6.3
10.6
27
43
Z3226
NOMESCO Finland
Physiotherapist
1.7
10.6
230
1425
N05CD07
ATC
temazepam; oral
1.6
10.5
310
2090
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.7
10.4
232
1448
F01.23
ICD-10 Finland
Subcortical vascular dementia other additional symptoms, mainly depression
+∞
10.4
10
*
L89
ICD-10 Finland
Decubitus ulcer and pressure area
3.2
10.3
52
163
F00
ICD-10 Finland
Dementia in Alzheimer disease
32.5
10.3
13
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
10.2
157
869
N03AF02
ATC
oxcarbazepine; oral
3.7
10.1
43
118
B01AA03
ATC
warfarin; systemic
1.5
9.9
533
4107
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
2.4
9.8
80
338
F07.9
ICD-10 Finland
Unspecified organic personality and behavioural disorder due to brain disease, damage and dysfunction
26.0
9.8
13
5
G04CA02
ATC
tamsulosin; oral
1.5
9.8
462
3461
SPAT1172
SPAT
Guidance concerning hydration
2.7
9.7
65
246
ZXD05
NOMESCO Finland
Urgent procedure
1.5
9.6
416
3059
F0009, G300
ICD-10 Finland
NA
+∞
9.4
9
*
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
+∞
9.4
9
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
9.2
293
2007
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.1
9.2
108
542
ZXD35
NOMESCO Finland
Usual procedure
2.7
9.1
59
220
R4110
NOMESCO Finland
Physiotherapy
1.6
9.0
282
1921
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
8.9
169
1005
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
1.9
8.8
138
771
F01.84
ICD-10 Finland
Other specified vascular dementia other mixed symptoms of mixed type
49.9
8.7
10
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
8.5
85
398
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.4
8.5
557
4416
F22.0
ICD-10 Finland
Delusional disorder
4.8
8.5
27
57
F01.14
ICD-10 Finland
Multi-infarct dementia's other mixed symptoms of mixed type
89.9
8.4
9
*
S72.1
ICD-10 Finland
Pertrochanteric fracture
2.3
8.4
76
340
G04BD07
ATC
tolterodine; oral
1.9
8.4
114
606
SPAT1229
SPAT
Assessment of need for aid
1.8
8.2
130
728
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.7
8.2
172
1052
G04BD04
ATC
oxybutynin; oral, transdermal
1.8
8.1
136
775
J01MA02
ATC
ciprofloxacin; systemic
1.4
8.0
549
4375
SPAT1262
SPAT
Handing over of treatment supplies
1.6
8.0
213
1391
S20.2
ICD-10 Finland
Contusion of thorax
2.4
8.0
63
264
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
2.3
7.9
72
322
SPAT1167
SPAT
Insertion of urinary catheter
2.2
7.8
73
332
SPAT1255
SPAT
Intravenous administration of medicine
2.1
7.8
84
406
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.7
7.8
32
87
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
0.2
7.7
6
335
I67.2
ICD-10 Finland
Cerebral atherosclerosis
5.0
7.7
23
46
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
3.5
7.6
33
94
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.5
7.6
59
244
R11
ICD-10 Finland
Nausea and vomiting
1.8
7.5
122
688
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
4.0
7.4
28
71
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.7
7.4
150
908
SPAT1251
SPAT
Organisation of medication
2.1
7.4
79
381
F01.89
ICD-10 Finland
Other specified vascular dementia without information on additional symptoms
79.9
7.4
8
*
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
2.4
7.4
58
242
Z43.5
ICD-10 Finland
Attention to cystostomy
5.3
7.3
21
40
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.1
7.2
21
41
A10BB12
ATC
glimepiride; oral
1.6
7.2
184
1193
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
0.1
7.1
*
232
C07AB07
ATC
bisoprolol; oral
1.3
7.1
747
6340
A10AE05
ATC
insulin detemir; parenteral
2.2
7.1
72
339
A03FA01
ATC
metoclopramide; systemic, rectal
0.6
7.1
123
1904
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
7.1
432
3357
G46.8*I67.9
ICD-10 Finland
Other vascular syndromes of brain in cerebrovascular diseases
12.0
7.0
12
10
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.0
7.0
83
421
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
2.2
7.0
64
290
A10BA02
ATC
metformin; oral
1.4
6.9
417
3234
N06AX21
ATC
duloxetine; oral
2.1
6.8
75
367
R47.0
ICD-10 Finland
Dysphasia and aphasia
3.7
6.8
28
77
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.8
6.8
21
44
N03AF01
ATC
carbamazepine; oral, rectal
1.9
6.8
92
491
N05AX12
ATC
aripiprazole; systemic
9.3
6.8
13
14
F01.8
ICD-10 Finland
Other vascular dementia
39.9
6.7
8
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.7
6.7
27
73
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
6.7
393
3032
SPAT1279
SPAT
Preparation of immediate hospitalisation
3.1
6.7
34
111
SPAT1153
SPAT
Removal of sutures
0.6
6.6
158
2282
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
3.0
6.6
36
123
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.8
6.6
40
146
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.1
6.5
33
107
N39.9
ICD-10 Finland
Disorder of urinary system, unspecified
2.8
6.5
38
135
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
6.5
221
1531
Z2221
NOMESCO Finland
Medical doctor
1.4
6.5
291
2134
N06AB03
ATC
fluoxetine; oral
1.8
6.4
102
574
F00.19
ICD-10 Finland
Dementia in Alzheimer's disease with late onset without information about additional symptoms
69.6
6.4
7
*
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
4.2
6.4
22
52
8000/3-C34.9
ICD-O-3
Neoplasm, malignant of lung, NOS
0.2
6.3
7
315
N05AB03
ATC
perphenazine; systemic, rectal
2.7
6.3
39
144
R23.8
ICD-10 Finland
Other and unspecified skin changes
0.5
6.3
52
983
N29
ICPC
Neurological sympt/complt other
3.6
6.3
26
72
R31
ICD-10 Finland
Unspecified haematuria
1.6
6.3
179
1186
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.3
6.2
51
221
N05CF01
ATC
zopiclone; oral
1.3
6.2
527
4307
E000003
ATC
NA
2.4
6.1
50
215
103
Kela drug reimbursment
Diabetes, insulin-treated
1.4
6.1
441
3511
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.3
6.1
50
216
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
4.0
6.0
22
55
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
2.8
6.0
36
131
Mortality – FinRegistry
↥Association
Association between endpoint VD_U and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_U | 2.788 [2.44, 3.19] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.403 |
During the follow-up period (1.1.1998 — 31.12.2019), 8245 out of 10204 females with VD_U died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_U | 3.498 [2.89, 4.24] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 5642 out of 6992 males with VD_U died.
Mortality risk
Mortality risk for people of age
years, who have VD_U.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.305% | 0.651% |
| 5 | 1.807% | 4.251% |
| 10 | 4.236% | 9.817% |
| 15 | 8.247% | 18.241% |
| 20 | 13.913% | 30.207% |
Relationships between endpoints
↥Index endpoint: VD_U – Vascular dementia (undefined)
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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