No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
632 |
4. Check minimum number of eventsNone |
632 |
5. Include endpointsNone |
632 |
6. Filter based on genotype QC (FinnGen only) |
632 |
Control definitions (FinnGen only)
- Control exclude
- F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F01
- Name in latin
- Dementia e multis infarctibus
Similar endpoints
↥List of similar endpoints to
Vascular dementia (multiple infarctions)
based on the number of shared cases.
Similar with more cases:
- Vascular dementia
- Dementia
- Dementia, including avohilmo
- Organic, including symptomatic, mental disorders
- Psychiatric diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17740 | 8997 | 8189 |
| Only index persons | 5236 | 2717 | 2519 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.26 | 0.23 |
| Only index persons | 0.10 | 0.10 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 79.25 | 80.73 | 77.74 |
| Only index persons | 80.26 | 82.38 | 77.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 632 | 186 | 446 |
| Unadjusted period prevalence (%) | 0.16 | 0.06 | 0.20 |
| Median age at first event (years) | 76.77 | 78.54 | 76.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 584
- Matched controls
- 5840
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
+∞
262.8
232
*
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
2576.8
191.5
175
*
F01.1
ICD-10 Finland
Multi-infarct dementia
2362.9
180.9
166
*
F01.9
ICD-10 Finland
Vascular dementia, unspecified
222.4
137.1
137
8
F03
ICD-10 Finland
Unspecified dementia
81.9
133.7
148
24
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
7.9
84.4
225
428
N06DX01
ATC
memantine; oral
104.0
75.1
81
9
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
69.1
65
*
N06DA02
ATC
donepezil; oral
121.3
61.2
65
6
N05AX08
ATC
risperidone; systemic
10.5
55.8
115
133
4378A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Other[MULTI-INFARKTIDEMENTIA]
+∞
52.9
50
*
G30.1
ICD-10 Finland
Alzheimer disease with late onset
56.4
51.9
61
12
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
4.5
49.6
220
695
N05AH04
ATC
quetiapine; oral
7.2
46.5
122
206
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
101.8
43.4
47
5
F01.0
ICD-10 Finland
Vascular dementia of acute onset
+∞
43.2
41
*
N06DA03
ATC
rivastigmine; oral, transdermal
112.7
39.2
42
*
4378X
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Other[MORBUS CERBROVASCULARIS ALIA DEFINITA]
+∞
36.8
35
*
F01.14
ICD-10 Finland
Multi-infarct dementia's other mixed symptoms of mixed type
+∞
36.8
35
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
6.3
30.7
86
155
N03AG01
ATC
valproic acid; systemic, rectal
10.9
27.8
54
54
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
39.9
27.4
34
9
G30.8
ICD-10 Finland
Other Alzheimer disease
65.1
27.2
31
5
N05AD03
ATC
melperone; systemic
9.0
25.9
56
68
B01AC07
ATC
dipyridamole; systemic
3.5
25.9
140
485
N06AB04
ATC
citalopram; systemic
3.0
23.6
163
668
N06DA04
ATC
galantamine; oral
46.9
22.5
27
6
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
46.9
22.5
27
6
R41.0
ICD-10 Finland
Disorientation, unspecified
6.8
22.1
57
91
F01.11
ICD-10 Finland
The other additional symptoms of multi-infarct dementia, mainly paranoidism
+∞
20.9
20
*
N05AD01
ATC
haloperidol; systemic
5.4
20.6
64
130
Z75.5
ICD-10 Finland
Holiday relief care
9.9
19.9
40
43
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.5
19.7
47
67
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
3.3
19.2
106
367
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
45.5
18.3
22
5
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.1
18.3
59
125
2900A
ICD-9 Finland
Senile and presenile organic psychotic conditions, Senile dementia, uncomplicated
+∞
17.8
17
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.8
17.2
49
90
F01.12
ICD-10 Finland
The other additional symptoms of multi-infarct dementia, mainly hallucinations
+∞
16.7
16
*
P70
ICPC
Dementia
11.2
15.6
29
27
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.5
15.4
75
234
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
14.6
252
1577
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
76.8
13.6
15
*
F01.13
ICD-10 Finland
The other additional symptoms of multi-infarct dementia, mainly depression
+∞
12.5
12
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.5
12.5
44
103
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
132.4
12.5
13
*
R53
ICD-10 Finland
Malaise and fatigue
2.2
12.2
140
727
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
6.1
11.9
32
55
N03AF02
ATC
oxcarbazepine; oral
6.9
11.9
29
44
F01.3
ICD-10 Finland
Mixed cortical and subcortical vascular dementia
+∞
11.5
11
*
F0019, G301
ICD-10 Finland
NA
+∞
11.5
11
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.7
11.4
81
328
F01
ICD-10 Finland
Vascular dementia
44.1
10.9
13
*
F05.1
ICD-10 Finland
Delirium superimposed on dementia
21.9
10.7
15
7
F01.2
ICD-10 Finland
Subcortical vascular dementia
61.0
10.6
12
*
N05AH03
ATC
olanzapine; systemic
7.0
10.5
25
37
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
3.5
10.2
48
147
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
10.1
196
1238
P20
ICPC
Memory disturbance
2.5
10.0
82
359
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
7.8
10.0
22
29
Z2445
NOMESCO Finland
Psychologist
8.9
9.8
20
23
N05BA06
ATC
lorazepam; systemic, sublingual
3.3
9.8
48
152
130
Kela drug reimbursment
Malignant tumour
0.1
9.7
6
387
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
55.8
9.7
11
*
N05BA04
ATC
oxazepam; oral
2.0
9.5
137
772
A06AD11
ATC
lactulose; oral
1.9
9.1
163
998
F10.20
ICD-10 Finland
Alcohol dependence currently independent
24.4
8.9
12
5
N06AX11
ATC
mirtazapine; oral
1.9
8.9
140
817
F05.9
ICD-10 Finland
Delirium, unspecified
4.7
8.9
29
64
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
8.8
29
746
F009, G309
ICD-10 Finland
NA
+∞
8.3
8
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
8.0
107
583
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
3.1
7.8
42
143
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
4.1
7.7
29
74
AA1AD
NOMESCO Finland
CT of head and brain
1.9
7.7
132
786
4019X
ICD-9 Finland
Essential hypertension, Unspecified
2.4
7.5
63
280
G30
ICD-10 Finland
Alzheimer disease
80.9
7.4
8
*
S01.0
ICD-10 Finland
Open wound of scalp
2.6
7.3
51
205
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
3.8
7.2
29
79
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.7
7.1
47
184
A98
ICPC
Health maint/preventive medicine
0.6
7.0
191
2567
A10AE04
ATC
insulin glargine; parenteral
2.5
6.9
52
219
SPAT1053
SPAT
Memory test
2.0
6.8
91
494
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.0
6.7
38
133
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.3
6.6
60
275
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
3.0
6.5
37
130
N06AB10
ATC
escitalopram; oral
2.3
6.5
57
258
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.9
6.4
97
552
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
14.5
6.4
10
7
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.0
6.4
78
408
L15
ICPC
Knee symptom/complaint
0.3
6.3
12
398
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.3
6.3
29
90
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
2.8
6.1
36
132
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
12.7
6.1
10
8
315
Kela drug reimbursment
Clopidogrel
4.2
6.0
21
51
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
5.6
6.0
16
29
Mortality – FinRegistry
↥Association
Association between endpoint VD_MI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_MI | 2.991 [2.64, 3.39] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.916 |
During the follow-up period (1.1.1998 — 31.12.2019), 3138 out of 3584 females with VD_MI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_MI | 3.558 [2.97, 4.26] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 2806 out of 3330 males with VD_MI died.
Mortality risk
Mortality risk for people of age
years, who have VD_MI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.241% | 0.492% |
| 5 | 1.79% | 3.705% |
| 10 | 4.924% | 9.421% |
| 15 | 9.633% | 17.903% |
| 20 | 16.907% | 28.507% |
Relationships between endpoints
↥Index endpoint: VD_MI – Vascular dementia (multiple infarctions)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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