No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
632 |
4. Check minimum number of eventsNone |
632 |
5. Include endpointsNone |
632 |
6. Filter based on genotype QC (FinnGen only) |
632 |
Control definitions (FinnGen only)
- Control exclude
- F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F01
- Name in latin
- Dementia e multis infarctibus
Similar endpoints
↥List of similar endpoints to
Vascular dementia (multiple infarctions)
based on the number of shared cases.
Similar with more cases:
- Vascular dementia
- Dementia
- Dementia, including avohilmo
- Organic, including symptomatic, mental disorders
- Psychiatric diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17740 | 8997 | 8189 |
| Only index persons | 5236 | 2717 | 2519 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.26 | 0.23 |
| Only index persons | 0.10 | 0.10 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 79.25 | 80.73 | 77.74 |
| Only index persons | 80.26 | 82.38 | 77.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 632 | 186 | 446 |
| Unadjusted period prevalence (%) | 0.16 | 0.06 | 0.20 |
| Median age at first event (years) | 76.77 | 78.54 | 76.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 584
- Matched controls
- 5840
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
+∞
262.8
232
*
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
2576.8
191.5
175
*
F01.1
ICD-10 Finland
Multi-infarct dementia
2362.9
180.9
166
*
F01.9
ICD-10 Finland
Vascular dementia, unspecified
222.4
137.1
137
8
F03
ICD-10 Finland
Unspecified dementia
81.9
133.7
148
24
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
7.9
84.4
225
428
N06DX01
ATC
memantine; oral
104.0
75.1
81
9
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
69.1
65
*
N06DA02
ATC
donepezil; oral
121.3
61.2
65
6
N05AX08
ATC
risperidone; systemic
10.5
55.8
115
133
4378A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Other[MULTI-INFARKTIDEMENTIA]
+∞
52.9
50
*
G30.1
ICD-10 Finland
Alzheimer disease with late onset
56.4
51.9
61
12
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
4.5
49.6
220
695
N05AH04
ATC
quetiapine; oral
7.2
46.5
122
206
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
101.8
43.4
47
5
F01.0
ICD-10 Finland
Vascular dementia of acute onset
+∞
43.2
41
*
N06DA03
ATC
rivastigmine; oral, transdermal
112.7
39.2
42
*
4378X
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Other[MORBUS CERBROVASCULARIS ALIA DEFINITA]
+∞
36.8
35
*
F01.14
ICD-10 Finland
Multi-infarct dementia's other mixed symptoms of mixed type
+∞
36.8
35
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
6.3
30.7
86
155
N03AG01
ATC
valproic acid; systemic, rectal
10.9
27.8
54
54
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
39.9
27.4
34
9
G30.8
ICD-10 Finland
Other Alzheimer disease
65.1
27.2
31
5
N05AD03
ATC
melperone; systemic
9.0
25.9
56
68
B01AC07
ATC
dipyridamole; systemic
3.5
25.9
140
485
N06AB04
ATC
citalopram; systemic
3.0
23.6
163
668
N06DA04
ATC
galantamine; oral
46.9
22.5
27
6
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
46.9
22.5
27
6
R41.0
ICD-10 Finland
Disorientation, unspecified
6.8
22.1
57
91
F01.11
ICD-10 Finland
The other additional symptoms of multi-infarct dementia, mainly paranoidism
+∞
20.9
20
*
N05AD01
ATC
haloperidol; systemic
5.4
20.6
64
130
Z75.5
ICD-10 Finland
Holiday relief care
9.9
19.9
40
43
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.5
19.7
47
67
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
3.3
19.2
106
367
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
45.5
18.3
22
5
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.1
18.3
59
125
2900A
ICD-9 Finland
Senile and presenile organic psychotic conditions, Senile dementia, uncomplicated
+∞
17.8
17
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.8
17.2
49
90
F01.12
ICD-10 Finland
The other additional symptoms of multi-infarct dementia, mainly hallucinations
+∞
16.7
16
*
P70
ICPC
Dementia
11.2
15.6
29
27
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.5
15.4
75
234
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
14.6
252
1577
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
76.8
13.6
15
*
F01.13
ICD-10 Finland
The other additional symptoms of multi-infarct dementia, mainly depression
+∞
12.5
12
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.5
12.5
44
103
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
132.4
12.5
13
*
R53
ICD-10 Finland
Malaise and fatigue
2.2
12.2
140
727
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
6.1
11.9
32
55
N03AF02
ATC
oxcarbazepine; oral
6.9
11.9
29
44
F01.3
ICD-10 Finland
Mixed cortical and subcortical vascular dementia
+∞
11.5
11
*
F0019, G301
ICD-10 Finland
NA
+∞
11.5
11
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.7
11.4
81
328
F01
ICD-10 Finland
Vascular dementia
44.1
10.9
13
*
F05.1
ICD-10 Finland
Delirium superimposed on dementia
21.9
10.7
15
7
F01.2
ICD-10 Finland
Subcortical vascular dementia
61.0
10.6
12
*
N05AH03
ATC
olanzapine; systemic
7.0
10.5
25
37
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
3.5
10.2
48
147
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
10.1
196
1238
P20
ICPC
Memory disturbance
2.5
10.0
82
359
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
7.8
10.0
22
29
N05BA06
ATC
lorazepam; systemic, sublingual
3.3
9.8
48
152
130
Kela drug reimbursment
Malignant tumour
0.1
9.7
6
387
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
55.8
9.7
11
*
N05BA04
ATC
oxazepam; oral
2.0
9.5
137
772
A06AD11
ATC
lactulose; oral
1.9
9.1
163
998
F10.20
ICD-10 Finland
Alcohol dependence currently independent
24.4
8.9
12
5
N06AX11
ATC
mirtazapine; oral
1.9
8.9
140
817
F05.9
ICD-10 Finland
Delirium, unspecified
4.7
8.9
29
64
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
8.8
29
746
F009, G309
ICD-10 Finland
NA
+∞
8.3
8
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
8.0
107
583
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
3.1
7.8
42
143
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
4.1
7.7
29
74
AA1AD
NOMESCO Finland
CT of head and brain
1.9
7.7
132
786
4019X
ICD-9 Finland
Essential hypertension, Unspecified
2.4
7.5
63
280
G30
ICD-10 Finland
Alzheimer disease
80.9
7.4
8
*
S01.0
ICD-10 Finland
Open wound of scalp
2.6
7.3
51
205
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
3.8
7.2
29
79
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.7
7.1
47
184
A98
ICPC
Health maint/preventive medicine
0.6
7.0
191
2567
A10AE04
ATC
insulin glargine; parenteral
2.5
6.9
52
219
SPAT1053
SPAT
Memory test
2.0
6.8
91
494
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.0
6.7
38
133
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.3
6.6
60
275
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
3.0
6.5
37
130
N06AB10
ATC
escitalopram; oral
2.3
6.5
57
258
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.9
6.4
97
552
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
14.5
6.4
10
7
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.0
6.4
78
408
L15
ICPC
Knee symptom/complaint
0.3
6.3
12
398
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.3
6.3
29
90
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
2.8
6.1
36
132
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
12.7
6.1
10
8
315
Kela drug reimbursment
Clopidogrel
4.2
6.0
21
51
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
5.6
6.0
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
171
2407
0.60
7.32
4.3
4.5
3.83
4.17
mmol/l
4.78
157
2126
181
2510
0.61
7.27
4.8
5.1
2.11
2.36
mmol/l
4.25
168
2188
184
2533
0.61
7.12
4.7
5.1
6.29
6.22
mmol/l
0.24
156
2190
174
2424
0.61
7.06
22.9
19.7
66.33
64.89
ml/min/173m2
0.35
141
2037
170
2374
0.61
6.92
4.2
4.5
1.27
1.38
mmol/l
2.52
156
2064
169
2294
0.64
5.75
3.9
4.1
1.24
1.22
mmol/l
0.15
154
1984
152
2106
0.63
5.64
30.2
23.9
14.52
14.23
%
1.59
146
2038
186
2454
0.66
5.44
7.9
6.7
46.22
42.23
mmol/mol
2.86
166
2188
218
2775
0.67
5.27
10.7
10.5
28.48
24.29
u/l
0.48
201
2623
103
1474
0.64
4.18
4.3
5.7
2.45
8.34
ug/l
1.28
83
1270
25
543
0.44
4.18
4.0
2.6
20.50
21.22
%
0.11
20
474
154
2028
0.68
4.14
3.6
4.0
18.51
17.09
mm/h
0.35
136
1817
32
624
0.49
3.99
3.4
2.5
10.59
11.48
umol/l
0.53
27
573
49
818
0.56
3.69
3.0
3.3
0.86
0.95
ug/l
0.34
36
581
240
2885
0.73
3.65
34.7
28.5
4.21
4.27
e12/l
0.87
218
2759
240
2884
0.73
3.64
34.9
28.5
240.35
230.10
e9/l
1.37
223
2767
238
2858
0.73
3.57
30.8
24.2
3.99
4.05
mmol/l
2.04
218
2745
238
2856
0.73
3.54
30.9
24.1
139.71
139.31
mmol/l
1.27
220
2743
241
2885
0.73
3.52
34.9
28.8
126.87
128.86
g/l
1.11
225
2793
61
375
1.69
3.46
2.8
2.7
4.28
6.49
ug/l
1.38
51
320
114
823
1.47
3.24
2.0
1.8
1009.61
1183.80
nmol/l
1.47
91
613
84
1170
0.67
2.89
4.7
4.8
22.89
22.46
%
0.10
46
626
37
618
0.57
2.80
2.4
1.6
1.05
1.44
mg/l
1.35
30
489
70
990
0.67
2.59
3.5
3.9
15.01
11.68
mg/mmol
0.30
44
648
89
1203
0.70
2.59
2.8
2.8
141.21
165.33
ug/l
0.53
77
1076
72
1010
0.67
2.56
4.6
3.8
0.78
0.55
e6/l
0.32
64
812
196
2336
0.76
2.50
4.3
4.4
2.01
2.12
mu/l
0.58
178
2024
127
1602
0.74
2.41
6.1
7.9
5.31
4.52
e9/l
1.81
106
1383
151
1848
0.76
2.31
3.3
3.5
14.71
15.24
pmol/l
1.55
129
1611
192
2276
0.77
2.30
6.3
6.9
85.04
86.28
u/l
0.12
171
2098
6
165
0.36
2.17
5.7
2.2
—
—
—
0
0
239
2732
0.80
2.05
26.0
19.9
32.46
30.15
mg/l
0.47
212
2327
63
861
0.70
1.95
2.0
1.7
17.44
19.55
nmol/l
0.45
55
735
5
11
4.56
1.94
1.2
1.0
—
—
—
0
0
5
11
4.56
1.94
1.2
1.0
—
—
—
0
0
109
1359
0.76
1.87
2.8
3.5
1921.14
2867.64
ng/l
1.54
92
1200
9
200
0.44
1.86
1.2
1.3
—
—
—
0
0
36
230
1.60
1.85
1.6
1.5
—
—
—
0
0
61
829
0.71
1.83
2.5
2.9
7034.69
8027.19
umol/l
0.05
48
677
21
357
0.57
1.76
1.6
2.7
6.80
12.14
umol/l
1.41
15
303
197
2263
0.81
1.68
25.7
21.2
33.79
36.50
%
1.16
87
1291
136
1624
0.79
1.64
4.3
5.4
11.13
13.71
umol/l
2.22
123
1529
120
985
1.27
1.51
2.5
2.0
260.33
252.99
u/l
0.04
109
909
32
210
1.55
1.50
4.7
3.1
24.66
24.87
mmol/l
0.11
32
202
20
116
1.75
1.49
3.2
3.3
4.04
4.06
mmol/l
0.06
20
102
22
134
1.66
1.40
2.0
1.7
—
—
—
0
0
126
1487
0.81
1.35
6.8
5.4
1.19
1.20
mmol/l
1.50
107
1295
21
330
0.62
1.33
4.3
4.8
33.56
33.46
%
0.01
16
205
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
148
1.57
1.21
1.9
2.0
0.27
0.36
u/ml
0.58
16
83
19
295
0.63
1.17
6.4
3.8
1.21
1.22
mmol/l
0.40
14
251
0
34
0.00
1.16
0.0
1.6
—
2.52
—
0
27
110
1282
0.83
1.04
4.2
3.8
—
—
—
0
0
5
22
2.28
1.03
1.2
1.5
—
—
—
0
0
47
362
1.32
1.00
15.5
9.6
—
—
—
0
0
0
32
0.00
0.95
0.0
1.1
—
—
—
0
0
117
1338
0.84
0.90
3.9
4.8
—
—
—
0
0
26
185
1.42
0.90
3.5
2.4
0.75
0.67
%
0.67
26
180
0
24
0.00
0.79
0.0
3.4
—
—
—
0
0
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
0
25
0.00
0.79
0.0
1.0
—
5.12
—
0
5
147
1633
0.87
0.78
7.1
6.0
1.20
1.21
mmol/l
0.50
120
1316
16
230
0.69
0.74
1.6
1.6
—
—
—
0
0
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
21
153
1.38
0.67
2.2
1.9
—
—
—
0
0
47
385
1.24
0.67
3.8
3.6
2.15
2.05
mmol/l
0.09
39
295
39
477
0.80
0.63
6.2
4.7
1.05
1.05
mmol/l
0.02
33
440
97
1090
0.87
0.62
2.3
2.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
54
456
1.20
0.59
5.8
5.7
1.22
1.30
mmol/l
0.04
35
327
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
73
830
0.86
0.55
2.5
2.7
56.98
37.94
u/l
0.44
66
799
49
576
0.84
0.55
3.3
3.3
1.87
1.38
e6/l
0.46
31
357
8
122
0.65
0.55
4.3
3.2
—
2.72
—
0
13
53
453
1.18
0.52
5.8
5.7
4.87
5.06
kpa
0.73
46
417
53
454
1.18
0.51
5.8
5.7
11.03
11.09
kpa
0.04
46
420
34
279
1.23
0.50
2.0
1.6
—
—
—
0
0
28
343
0.81
0.48
2.5
2.4
63.70
65.21
g/l
0.50
22
307
17
128
1.34
0.47
1.3
1.2
—
—
—
0
0
7
47
1.49
0.47
1.3
1.2
—
—
—
0
0
48
556
0.85
0.47
3.3
3.5
1.52
2.01
e6/l
0.43
30
340
8
116
0.68
0.46
1.6
1.5
—
—
—
0
0
71
629
1.14
0.46
6.7
5.2
1.02
1.01
kg/l
0.50
11
103
130
1402
0.91
0.44
5.9
4.5
0.00
0.00
estimate
0.00
14
293
72
801
0.88
0.42
7.2
4.8
0.00
0.00
estimate
—
9
265
131
1408
0.91
0.41
6.0
4.7
0.00
0.00
estimate
0.00
12
280
5
33
1.52
0.41
1.4
1.6
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
12.45
—
0
6
177
1875
0.92
0.40
6.1
4.7
7.68
7.01
mmol/l
1.80
164
1760
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
130
1395
0.91
0.40
8.0
6.3
0.00
0.00
estimate
0.00
14
285
90
983
0.90
0.39
2.3
2.3
2.82
3.29
mg/l
1.35
72
839
132
1414
0.91
0.39
2.6
2.2
84.95
89.08
pmol/l
0.51
85
773
32
374
0.85
0.37
5.3
4.3
—
—
—
0
0
74
671
1.11
0.35
39.8
32.6
1.73
1.55
inr
0.48
15
89
7
55
1.27
0.30
2.0
1.5
—
—
—
0
0
67
728
0.91
0.28
2.1
2.6
—
—
—
0
0
134
1412
0.93
0.28
3.8
2.8
49.93
58.95
u/l
1.04
119
1271
104
1106
0.93
0.27
7.1
5.1
—
—
—
0
0
6
81
0.74
0.24
1.0
1.0
—
—
—
0
0
71
659
1.09
0.23
2.6
3.2
2.45
2.47
mmol/l
0.58
55
557
5
42
1.19
0.21
1.2
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
56.67
—
0
10
0
10
0.00
0.21
0.0
2.8
—
120.90
—
0
10
0
11
0.00
0.21
0.0
1.1
—
289.60
—
0
5
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
83
780
1.07
0.21
1.7
1.8
447.92
9076860.66
pmol/l
0.50
64
628
49
450
1.09
0.21
7.3
6.5
105.82
104.10
mmol/l
1.65
49
435
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
48
1.25
0.20
1.5
1.2
—
—
—
0
0
12
99
1.21
0.19
2.7
4.3
13.86
34.58
mg/l
—
7
68
102
1069
0.94
0.19
2.0
2.1
70.19
79.16
nmol/l
2.97
79
918
13
110
1.18
0.17
1.7
1.4
—
—
—
0
0
13
110
1.18
0.17
1.7
1.4
—
—
—
0
0
5
70
0.71
0.16
3.0
2.2
3.30
3.56
g/l
—
5
65
137
1417
0.96
0.16
4.6
4.4
34.29
33.55
g/l
0.84
125
1297
90
937
0.95
0.14
2.4
2.3
47.00
56.02
u/l
3.19
84
865
72
751
0.95
0.12
5.5
4.1
117.60
280.96
ng/l
1.12
64
675
67
640
1.05
0.11
2.2
1.8
—
—
—
0
0
5
44
1.14
0.10
1.2
1.3
—
—
—
0
0
43
451
0.95
0.09
1.9
1.7
—
—
—
0
0
141
1439
0.97
0.09
5.2
4.7
51.99
58.77
ng/l
0.22
113
1143
6
55
1.09
0.09
1.0
1.4
—
—
—
0
0
5
60
0.83
0.08
1.4
1.3
—
—
—
0
0
5
60
0.83
0.08
1.2
1.1
9.08
56.06
u/l
—
5
55
107
1042
1.03
0.08
2.5
3.1
2.33
2.34
mmol/l
0.52
88
886
19
205
0.92
0.08
9.1
7.6
23.76
24.66
mmol/l
0.55
13
179
5
65
0.77
0.08
1.6
1.4
—
—
—
0
0
7
67
1.04
0.08
1.4
1.4
—
—
—
0
0
8
95
0.84
0.06
1.9
1.4
—
—
—
0
0
12
130
0.92
0.05
5.4
4.4
25.57
24.57
mmol/l
0.64
12
125
24
251
0.95
0.04
2.3
3.8
113.19
103.96
ng/l
0.14
16
218
53
516
1.03
0.04
2.3
2.8
0.81
0.82
mmol/l
0.11
46
472
44
450
0.97
0.03
1.9
1.7
—
—
—
0
0
24
232
1.03
0.02
2.6
3.3
45.29
54.75
ml/min/173m2
—
7
117
18
173
1.04
0.01
2.1
1.7
0.56
2.77
ug/l
0.70
12
144
14
141
0.99
0.00
2.0
2.5
—
—
—
0
0
7
77
0.91
0.00
1.1
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
12.5
—
13.95
—
0
6
8
89
0.90
0.00
1.1
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
1031.38
—
0
8
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
5
49
1.02
0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
7
76
0.92
0.00
1.1
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
122.60
—
0
5
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
12.8
—
7.05
—
0
6
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
8.39
—
0
5
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint VD_MI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_MI | 2.991 [2.64, 3.39] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.916 |
During the follow-up period (1.1.1998 — 31.12.2019), 3138 out of 3584 females with VD_MI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_MI | 3.558 [2.97, 4.26] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 2806 out of 3330 males with VD_MI died.
Mortality risk
Mortality risk for people of age
years, who have VD_MI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.241% | 0.492% |
| 5 | 1.79% | 3.705% |
| 10 | 4.924% | 9.421% |
| 15 | 9.633% | 17.903% |
| 20 | 16.907% | 28.507% |
Relationships between endpoints
↥Index endpoint: VD_MI – Vascular dementia (multiple infarctions)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data