vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
545 |
4. Check minimum number of eventsNone |
545 |
5. Include endpointsNone |
545 |
6. Filter based on genotype QC (FinnGen only) |
545 |
Control definitions (FinnGen only)
- Control exclude
- F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F01
- Name in latin
- Dementia vascularis corticalis et subcorticalis mixta
Similar endpoints
↥List of similar endpoints to
Vascular dementia (mixed)
based on the number of shared cases.
Similar with more cases:
- Vascular dementia
- Any dementia
- Any dementia, excluding more controls
- Dementia
- Dementia, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6720 | 3614 | 3030 |
| Only index persons | 5076 | 2802 | 2274 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.08 |
| Only index persons | 0.10 | 0.10 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 82.65 | 84.38 | 80.68 |
| Only index persons | 83.34 | 85.10 | 81.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 545 | 200 | 345 |
| Unadjusted period prevalence (%) | 0.12 | 0.07 | 0.15 |
| Median age at first event (years) | 81.34 | 82.38 | 80.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 447
- Matched controls
- 4468
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F01.30
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without additional symptoms
3710.2
223.5
197
*
F01.3
ICD-10 Finland
Mixed cortical and subcortical vascular dementia
+∞
159.1
143
*
N06DX01
ATC
memantine; oral
159.7
115.6
118
10
F01.39
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without information on additional symptoms
+∞
106.6
98
*
F03
ICD-10 Finland
Unspecified dementia
49.8
86.5
104
27
N06DA02
ATC
donepezil; oral
109.6
75.9
81
9
G30.1
ICD-10 Finland
Alzheimer disease with late onset
58.8
63.5
74
15
F01.34
ICD-10 Finland
Mixed cortical and subcortical vascular dementia are other mixed symptoms of mixed type
648.5
59.1
57
*
N05AX08
ATC
risperidone; systemic
11.0
54.1
110
129
F01.9
ICD-10 Finland
Vascular dementia, unspecified
84.5
53.5
59
8
N06DA03
ATC
rivastigmine; oral, transdermal
122.5
51.0
54
5
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
6.3
49.8
154
344
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
45.6
43
*
P20
ICPC
Memory disturbance
5.8
43.9
145
344
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
7.6
43.5
111
186
N06DA04
ATC
galantamine; oral
102.3
42.7
46
5
A28
ICPC
Limited function/disability NOS
4.1
35.5
178
627
G30.8
ICD-10 Finland
Other Alzheimer disease
195.2
35.3
36
*
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
130.2
34.2
36
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.9
31.1
155
532
N05AH04
ATC
quetiapine; oral
6.0
30.8
92
185
SPAT1053
SPAT
Memory test
3.6
26.9
147
535
R41.0
ICD-10 Finland
Disorientation, unspecified
9.0
26.3
57
71
AA1AD
NOMESCO Finland
CT of head and brain
3.1
24.4
178
788
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.9
23.8
208
1034
R53
ICD-10 Finland
Malaise and fatigue
3.3
23.7
148
585
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.2
23.5
159
664
F01.33
ICD-10 Finland
Mixed cortical and subcortical vascular dementia other additional symptoms, mainly depression
+∞
23.1
22
*
L28
ICPC
Limited function/disability (L)
3.2
21.6
133
516
F05.1
ICD-10 Finland
Delirium superimposed on dementia
60.4
20.1
23
*
N06AB04
ATC
citalopram; systemic
3.2
19.9
124
482
N03AG01
ATC
valproic acid; systemic, rectal
9.3
19.6
41
48
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
26.4
18.4
25
10
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
+∞
17.8
17
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
3.6
17.6
85
270
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.6
17.3
86
280
N06AX11
ATC
mirtazapine; oral
2.6
16.8
147
698
F01.32
ICD-10 Finland
Mixed cortical and subcortical vascular dementia other additional symptoms, mainly hallucinations
+∞
16.8
16
*
F01.31
ICD-10 Finland
Mixed cortical and subcortical vascular dementia other additional symptoms, mainly paranoidism
176.3
16.6
17
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
4.2
16.4
66
178
SPAT1216
SPAT
Assessment of functional ability
2.9
15.8
112
466
F05.9
ICD-10 Finland
Delirium, unspecified
7.8
15.3
35
48
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
24.4
15.2
21
9
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
154.8
14.5
15
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.7
14.0
106
457
K90
ICPC
Stroke/cerebrovascular accident
5.4
12.8
38
75
N05BA04
ATC
oxazepam; oral
2.4
12.7
131
662
N30.0
ICD-10 Finland
Acute cystitis
2.7
11.9
88
371
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
66.7
11.7
13
*
N05AD01
ATC
haloperidol; systemic
5.4
11.5
34
67
P70
ICPC
Dementia
12.3
11.4
20
17
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
11.0
11.4
21
20
N05AH03
ATC
olanzapine; systemic
7.1
11.3
27
40
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.4
11.3
105
501
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
10.8
98
461
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.3
10.8
28
47
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
10.7
176
1081
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.1
10.6
33
69
R41.3
ICD-10 Finland
Other amnesia
5.8
10.5
29
53
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
+∞
10.5
10
*
F05.8
ICD-10 Finland
Other delirium
12.6
9.9
17
14
N05AD03
ATC
melperone; systemic
8.1
9.7
21
27
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.6
9.6
76
331
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.4
9.6
46
145
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.9
9.4
38
104
SPAT1234
SPAT
Support of social functional capacity
3.7
9.3
40
115
SPAT1360
SPAT
Extensive global examination
3.3
9.1
46
151
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.7
9.0
38
108
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
4.1
9.0
34
88
C10AA01
ATC
simvastatin; oral
1.8
8.8
252
1848
B01AC04
ATC
clopidogrel; oral
2.0
8.7
122
692
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.6
8.6
38
112
N02BE01
ATC
paracetamol; systemic, rectal
2.0
8.6
346
2843
N06AB10
ATC
escitalopram; oral
2.8
8.5
56
219
I95.1
ICD-10 Finland
Orthostatic hypotension
3.5
8.4
39
120
F01.0
ICD-10 Finland
Vascular dementia of acute onset
+∞
8.4
8
*
I10
ICD-10 Finland
Essential (primary) hypertension
1.8
8.2
305
2415
F06.7
ICD-10 Finland
Mild cognitive disorder
5.0
8.2
25
52
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
8.1
87
440
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
4.1
8.0
30
77
S72.0
ICD-10 Finland
Fracture of neck of femur
3.0
8.0
46
166
SPAT1254
SPAT
Administration of medicine
2.2
8.0
88
451
A06AD11
ATC
lactulose; oral
2.0
7.8
114
654
C07AB07
ATC
bisoprolol; oral
1.8
7.8
264
2014
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
45.8
7.7
9
*
R55
ICD-10 Finland
Syncope and collapse
2.3
7.7
74
357
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.2
7.6
39
130
K91
ICPC
Cerebrovascular disease
5.9
7.6
20
35
R4120
NOMESCO Finland
Occupational therapy
3.4
7.5
35
109
A04
ICPC
Weakness/tiredness general
2.3
7.5
72
345
WYA20
NOMESCO Finland
Home visit
6.6
7.5
18
28
G30
ICD-10 Finland
Alzheimer disease
+∞
7.3
7
*
N03AF02
ATC
oxcarbazepine; oral
5.2
7.2
21
42
F01
ICD-10 Finland
Vascular dementia
30.5
7.2
9
*
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.8
7.2
46
178
W06
ICD-10 Finland
Fall involving bed
12.3
7.1
12
10
F21
ICPC
NA
9.0
7.1
14
16
R42
ICD-10 Finland
Dizziness and giddiness
1.9
7.1
117
702
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.0
7.1
97
543
J01DB01
ATC
cefalexin; oral
1.7
7.1
296
2369
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
7.0
108
633
SPAT1301
SPAT
No procedures
1.8
7.0
148
965
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
8.5
6.9
14
17
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.0
6.8
86
468
I63.8
ICD-10 Finland
Other cerebral infarction
8.0
6.7
14
18
N05BA06
ATC
lorazepam; systemic, sublingual
3.0
6.6
37
130
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.6
6.6
21
47
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
5.5
6.5
18
34
Y94.0
ICD-10 Finland
Accident at home
5.5
6.5
18
34
SPAT1252
SPAT
Overall medication plan or its review
2.5
6.5
48
202
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
70.8
6.4
7
*
N18
ICPC
Paralysis/weakness
4.9
6.3
19
40
F0019, G301
ICD-10 Finland
NA
+∞
6.3
6
*
130
Kela drug reimbursment
Malignant tumour
0.2
6.1
7
306
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.3
6.1
29
93
S70.0
ICD-10 Finland
Contusion of hip
3.1
6.0
31
105
Z3226
NOMESCO Finland
Physiotherapist
2.0
6.0
84
472
Mortality – FinRegistry
↥Association
Association between endpoint VD_MX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_MX | 2.524 [2.11, 3.03] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.455 |
During the follow-up period (1.1.1998 — 31.12.2019), 1669 out of 2264 females with VD_MX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_MX | 3.271 [2.52, 4.24] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1385 out of 1903 males with VD_MX died.
Mortality risk
Mortality risk for people of age
years, who have VD_MX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.245% | 0.504% |
| 5 | 1.626% | 3.072% |
| 10 | 3.872% | 7.683% |
| 15 | 7.553% | 14.956% |
| 20 | 13.309% | 24.423% |
Relationships between endpoints
↥Index endpoint: VD_MX – Vascular dementia (mixed)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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