vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1061 |
4. Check minimum number of eventsNone |
1061 |
5. Include endpointsNone |
1061 |
6. Filter based on genotype QC (FinnGen only) |
1061 |
Control definitions (FinnGen only)
- Control exclude
- F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F01
- Name in latin
- Dementia vascularis subcorticalis
Similar endpoints
↥List of similar endpoints to
Vascular dementia (subcortical)
based on the number of shared cases.
Similar with more cases:
- Vascular dementia
- Any dementia
- Any dementia, excluding more controls
- Dementia
- Dementia, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12884 | 7551 | 5236 |
| Only index persons | 10927 | 6528 | 4399 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.22 | 0.15 |
| Only index persons | 0.21 | 0.24 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 82.23 | 83.77 | 80.07 |
| Only index persons | 82.70 | 84.21 | 80.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1061 | 450 | 611 |
| Unadjusted period prevalence (%) | 0.22 | 0.15 | 0.27 |
| Median age at first event (years) | 81.05 | 82.45 | 80.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 896
- Matched controls
- 8959
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
746.3
323.0
427
11
F01.2
ICD-10 Finland
Subcortical vascular dementia
786.3
323.0
312
6
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
+∞
300.4
271
*
N06DX01
ATC
memantine; oral
169.6
260.1
264
22
G30.1
ICD-10 Finland
Alzheimer disease with late onset
110.6
216.9
231
28
N06DA02
ATC
donepezil; oral
108.6
163.1
175
20
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
11.8
156.3
320
403
F03
ICD-10 Finland
Unspecified dementia
41.0
146.1
184
56
F01.9
ICD-10 Finland
Vascular dementia, unspecified
89.1
129.9
143
19
N06DA03
ATC
rivastigmine; oral, transdermal
184.5
123.9
127
8
N05AX08
ATC
risperidone; systemic
12.1
116.1
227
245
P20
ICPC
Memory disturbance
6.7
109.8
333
730
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
94.5
89
*
F01.24
ICD-10 Finland
Subcortical vascular dementia other additional symptoms of mixed type
827.3
78.6
76
*
N05AH04
ATC
quetiapine; oral
7.2
78.3
208
359
N06DA04
ATC
galantamine; oral
405.1
76.0
75
*
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
163.4
72.2
75
5
A28
ICPC
Limited function/disability NOS
4.0
68.4
354
1258
R41.3
ICD-10 Finland
Other amnesia
12.0
59.8
113
106
P70
ICPC
Dementia
26.0
59.2
83
35
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.1
54.5
439
2107
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
59.3
52.3
61
11
R53
ICD-10 Finland
Malaise and fatigue
3.3
51.6
333
1349
F01.23
ICD-10 Finland
Subcortical vascular dementia other additional symptoms, mainly depression
+∞
44.1
42
*
SPAT1053
SPAT
Memory test
3.1
41.0
285
1179
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.6
37.9
191
619
G30.8
ICD-10 Finland
Other Alzheimer disease
62.8
36.5
42
7
R41.0
ICD-10 Finland
Disorientation, unspecified
6.8
36.4
96
156
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
12.9
35.7
64
53
F05.1
ICD-10 Finland
Delirium superimposed on dementia
54.9
35.7
42
8
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
30.0
32.3
43
15
F01.21
ICD-10 Finland
Subcortical vascular dementia without additional symptoms, mainly paranoidism
155.0
28.8
30
*
N06AX11
ATC
mirtazapine; oral
2.5
28.7
297
1499
N02BE01
ATC
paracetamol; systemic, rectal
2.6
27.9
742
5855
F01
ICD-10 Finland
Vascular dementia
149.6
27.8
29
*
F01.22
ICD-10 Finland
Subcortical vascular dementia with additional symptoms, mainly hallucinations
279.0
26.9
27
*
N05BA04
ATC
oxazepam; oral
2.5
26.2
263
1297
N06AB10
ATC
escitalopram; oral
3.2
25.8
148
517
G30
ICD-10 Finland
Alzheimer disease
267.9
25.8
26
*
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
139.0
25.7
27
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
24.6
367
2177
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
128.4
23.7
25
*
L28
ICPC
Limited function/disability (L)
2.4
23.3
235
1152
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.4
22.3
214
1019
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.0
21.8
91
246
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.9
21.8
148
578
F05.9
ICD-10 Finland
Delirium, unspecified
6.4
21.7
58
96
TAB00
NOMESCO Finland
Lumbar puncture
7.4
20.9
50
71
N05AH03
ATC
olanzapine; systemic
6.6
20.8
54
86
F01.0
ICD-10 Finland
Vascular dementia of acute onset
214.7
20.7
21
*
N03AG01
ATC
valproic acid; systemic, rectal
5.5
20.2
61
118
N06AB04
ATC
citalopram; systemic
2.3
19.1
205
1021
G30.0
ICD-10 Finland
Alzheimer disease with early onset
+∞
18.8
18
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.3
18.8
205
1029
F06.7
ICD-10 Finland
Mild cognitive disorder
4.9
18.8
62
133
AA1AD
NOMESCO Finland
CT of head and brain
2.1
18.7
285
1660
S01.0
ICD-10 Finland
Open wound of scalp
3.1
18.3
107
374
S06.0
ICD-10 Finland
Concussion
2.9
18.3
120
453
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.7
18.1
137
568
N06AX26
ATC
vortioxetine; oral
6.5
18.0
47
76
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.9
17.4
109
402
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
17.2
635
5029
SPAT1216
SPAT
Assessment of functional ability
2.2
17.2
207
1086
R42
ICD-10 Finland
Dizziness and giddiness
2.0
16.9
265
1549
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
16.8
193
989
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
16.8
240
1350
R4110
NOMESCO Finland
Physiotherapy
2.0
16.4
255
1481
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.6
16.0
74
219
S72.0
ICD-10 Finland
Fracture of neck of femur
3.0
15.6
93
330
J01DB01
ATC
cefalexin; oral
1.8
15.3
626
5015
WYA20
NOMESCO Finland
Home visit
7.7
15.3
35
47
XA800
NOMESCO Finland
Neuropsychological investigation
6.3
14.4
38
63
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
14.3
178
938
U04
ICPC
Incontinence urine
3.2
13.8
75
251
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
76.3
13.6
15
*
F01.30
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without additional symptoms
76.3
13.6
15
*
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
7.9
13.4
30
39
R55
ICD-10 Finland
Syncope and collapse
2.2
13.4
146
725
A06AD11
ATC
lactulose; oral
1.9
13.2
223
1321
I95.1
ICD-10 Finland
Orthostatic hypotension
3.4
13.1
65
203
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.0
12.8
74
258
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
70.9
12.6
14
*
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
+∞
12.5
12
*
Z02.7
ICD-10 Finland
Issue of medical certificate
3.0
12.4
72
252
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
3.4
12.4
60
185
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
6.0
12.2
33
57
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.8
11.8
77
290
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.2
11.8
61
197
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.9
11.8
74
274
Z75.5
ICD-10 Finland
Holiday relief care
7.0
11.7
28
41
F009, G309
ICD-10 Finland
NA
+∞
11.5
11
*
F0019, G301
ICD-10 Finland
NA
+∞
11.5
11
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.1
11.4
44
112
Z3226
NOMESCO Finland
Physiotherapist
1.9
11.4
178
1018
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.2
11.4
123
606
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
3.0
11.3
66
233
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.3
10.7
105
496
Z3231
NOMESCO Finland
Registered nurse
1.7
10.7
262
1740
N06AB06
ATC
sertraline; oral
2.9
10.6
65
236
C10AA01
ATC
simvastatin; oral
1.6
10.6
488
3835
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
10.5
270
1815
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
5.7
10.5
29
52
A04
ICPC
Weakness/tiredness general
2.0
10.4
150
831
F01.3
ICD-10 Finland
Mixed cortical and subcortical vascular dementia
+∞
10.4
10
*
A29
ICPC
General symptom/complaint other
2.1
10.4
119
603
N02AA05
ATC
oxycodone; systemic
1.8
10.2
179
1065
F21
ICPC
NA
6.0
10.2
27
46
130
Kela drug reimbursment
Malignant tumour
0.3
10.1
16
593
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.8
10.1
186
1126
F29
ICD-10 Finland
Unspecified nonorganic psychosis
7.3
10.0
23
32
SPAT1254
SPAT
Administration of medicine
1.9
10.0
169
990
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.9
9.7
57
202
N30.0
ICD-10 Finland
Acute cystitis
1.9
9.7
141
785
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
9.6
158
919
ZXA05
NOMESCO Finland
Left side
1.7
9.6
263
1789
G04BD12
ATC
mirabegron; oral
2.1
9.6
113
579
R44.3
ICD-10 Finland
Hallucinations, unspecified
15.2
9.5
15
10
Z2221
NOMESCO Finland
Medical doctor
1.7
9.4
238
1584
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
9.3
130
711
W19
ICD-10 Finland
Unspecified fall
2.2
9.3
98
479
A10AE04
ATC
insulin glargine; parenteral
2.2
9.1
94
454
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
5.8
8.9
24
42
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.4
8.9
76
337
H25.1
ICD-10 Finland
Senile nuclear cataract
1.5
8.8
393
3016
N05BA06
ATC
lorazepam; systemic, sublingual
2.6
8.8
64
261
ZXD35
NOMESCO Finland
Usual procedure
3.1
8.7
47
159
ZXA00
NOMESCO Finland
Right side
1.6
8.6
274
1931
WX212
NOMESCO Finland
Femoral plexus blockade
3.8
8.5
35
96
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
2.9
8.5
51
185
C07AB07
ATC
bisoprolol; oral
1.5
8.5
511
4181
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
90.9
8.4
9
*
Y94.0
ICD-10 Finland
Accident at home
4.1
8.4
31
77
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.2
8.3
43
141
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.8
8.3
53
200
R11
ICD-10 Finland
Nausea and vomiting
2.1
8.2
88
434
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
8.1
142
839
G21.8
ICD-10 Finland
Other secondary parkinsonism
33.7
8.1
10
*
A02BC02
ATC
pantoprazole; systemic
1.5
8.1
517
4263
N05AD01
ATC
haloperidol; systemic
3.0
8.0
43
146
P99
ICPC
Psychological disorders other
7.9
7.9
17
22
G04BD07
ATC
tolterodine; oral
2.2
7.6
75
354
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.5
7.6
33
96
SPAT1360
SPAT
Extensive global examination
2.2
7.5
75
358
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.5
7.5
25
57
EBA00
NOMESCO Finland
Extraction of tooth
1.6
7.5
200
1343
S72.1
ICD-10 Finland
Pertrochanteric fracture
2.7
7.4
48
183
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.7
7.4
30
82
F01.80
ICD-10 Finland
Other specified vascular dementia without additional symptoms
+∞
7.3
7
*
F01.1
ICD-10 Finland
Multi-infarct dementia
+∞
7.3
7
*
XCK10
NOMESCO Finland
Photography of fundus of eye
1.9
7.3
111
627
A98
ICPC
Health maint/preventive medicine
1.5
7.1
638
5571
A23
ICPC
Risk factor NOS
2.8
7.1
42
152
NFJ54
NOMESCO Finland
Internal fixation of fracture of upper femur with intramedullary nail
3.3
7.1
34
107
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
7.1
303
2273
S70.0
ICD-10 Finland
Contusion of hip
2.6
7.0
49
195
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
7.0
194
1311
S01
ICD-10 Finland
Open wound of head
5.2
7.0
20
39
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
3.6
6.9
29
82
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
6.9
176
1163
P29
ICPC
Psychological sympt/compl other
4.4
6.9
23
53
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
4.1
6.8
25
63
G20
ICD-10 Finland
Parkinson disease
2.8
6.8
40
145
C10AA05
ATC
atorvastatin; oral
1.5
6.8
351
2731
R32
ICD-10 Finland
Unspecified urinary incontinence
3.1
6.7
35
117
Y94.8
ICD-10 Finland
Other leisure activity accident
4.0
6.7
25
64
F00
ICD-10 Finland
Dementia in Alzheimer disease
22.7
6.7
9
*
WX110
NOMESCO Finland
Local anesthesy
1.4
6.6
404
3243
A10BA02
ATC
metformin; oral
1.5
6.6
274
2037
ZXE00
NOMESCO Finland
One hour or less
1.5
6.5
308
2349
N30.9
ICD-10 Finland
Cystitis, unspecified
2.1
6.5
67
325
C09AA05
ATC
ramipril; oral
1.5
6.4
280
2097
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
2.1
6.4
67
326
SPAT1229
SPAT
Assessment of need for aid
1.9
6.4
95
529
K08.3
ICD-10 Finland
Retained dental root
2.2
6.4
60
279
A10BH05
ATC
linagliptin; oral
2.2
6.4
62
292
G72.8
ICD-10 Finland
Other specified myopathies
3.9
6.4
24
62
C02AC05
ATC
moxonidine; oral
2.3
6.4
54
239
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
6.3
363
2872
N06AX21
ATC
duloxetine; oral
2.1
6.3
66
324
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.7
6.3
123
755
F01.39
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without information on additional symptoms
+∞
6.3
6
*
J01CA04
ATC
amoxicillin; systemic
1.4
6.2
557
4790
P15
ICPC
Chronic alcohol abuse
7.1
6.2
14
20
J01MA02
ATC
ciprofloxacin; systemic
1.4
6.1
350
2763
Z2445
NOMESCO Finland
Psychologist
4.7
6.1
19
41
Z01.9
ICD-10 Finland
Special examination, unspecified
2.4
6.0
49
212
R50.9
ICD-10 Finland
Fever, unspecified
1.7
6.0
114
689
G04BD08
ATC
solifenacin; oral
2.0
6.0
73
381
Mortality – FinRegistry
↥Association
Association between endpoint VD_SC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_SC | 2.216 [1.92, 2.56] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 3411 out of 5576 females with VD_SC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_SC | 2.752 [2.26, 3.34] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2589 out of 3954 males with VD_SC died.
Mortality risk
Mortality risk for people of age
years, who have VD_SC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.19% | 0.439% |
| 5 | 0.887% | 2.567% |
| 10 | 2.593% | 6.823% |
| 15 | 5.147% | 12.85% |
| 20 | 8.771% | 21.239% |
Relationships between endpoints
↥Index endpoint: VD_SC – Vascular dementia (subcortical)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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