vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
203 |
4. Check minimum number of eventsNone |
203 |
5. Include endpointsNone |
203 |
6. Filter based on genotype QC (FinnGen only) |
203 |
Control definitions (FinnGen only)
- Control exclude
- F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F01
- Name in latin
- Alia dementia vascularis specificata
Similar endpoints
↥List of similar endpoints to
Vascular dementia (other)
based on the number of shared cases.
Similar with more cases:
- Vascular dementia
- Any dementia
- Any dementia, excluding more controls
- Dementia
- Dementia, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2901 | 1663 | 1210 |
| Only index persons | 2238 | 1308 | 930 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 82.87 | 84.43 | 80.83 |
| Only index persons | 83.63 | 85.02 | 81.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 203 | 77 | 126 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.06 |
| Median age at first event (years) | 82.14 | 82.68 | 81.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 166
- Matched controls
- 1660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F01.80
ICD-10 Finland
Other specified vascular dementia without additional symptoms
+∞
57.7
52
*
F01.8
ICD-10 Finland
Other vascular dementia
742.4
56.0
52
*
F01.9
ICD-10 Finland
Vascular dementia, unspecified
324.7
48.8
47
*
N06DX01
ATC
memantine; oral
95.7
40.2
43
6
N05AX08
ATC
risperidone; systemic
19.4
38.5
61
48
F01.89
ICD-10 Finland
Other specified vascular dementia without information on additional symptoms
+∞
35.7
33
*
F03
ICD-10 Finland
Unspecified dementia
45.7
32.3
39
11
F01.84
ICD-10 Finland
Other specified vascular dementia other mixed symptoms of mixed type
278.4
24.3
24
*
N06DA04
ATC
galantamine; oral
59.6
18.4
21
*
N05AH04
ATC
quetiapine; oral
7.0
17.3
46
86
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
+∞
17.0
16
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
5.6
16.4
53
127
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
7.6
16.0
39
64
F01.81
ICD-10 Finland
Other specified vascular dementia has other additional symptoms, mainly paranoidism
+∞
15.9
15
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
4.0
15.6
89
374
N06DA02
ATC
donepezil; oral
30.3
14.6
19
7
R41.0
ICD-10 Finland
Disorientation, unspecified
12.6
14.6
26
24
R53
ICD-10 Finland
Malaise and fatigue
4.2
14.3
65
219
G30.1
ICD-10 Finland
Alzheimer disease with late onset
33.3
14.2
18
6
P20
ICPC
Memory disturbance
4.9
14.1
52
142
A28
ICPC
Limited function/disability NOS
4.0
13.3
65
231
G30.8
ICD-10 Finland
Other Alzheimer disease
140.1
12.6
13
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.8
11.4
56
196
SPAT1053
SPAT
Memory test
3.6
11.4
62
234
L28
ICPC
Limited function/disability (L)
3.6
11.0
59
221
AA1AD
NOMESCO Finland
CT of head and brain
3.3
10.9
70
300
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
10.5
10
*
N06AX11
ATC
mirtazapine; oral
3.2
10.1
68
299
N03AG01
ATC
valproic acid; systemic, rectal
8.4
9.8
21
28
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.2
9.6
61
256
N06DA03
ATC
rivastigmine; oral, transdermal
105.7
9.5
10
*
F01
ICD-10 Finland
Vascular dementia
105.7
9.5
10
*
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
+∞
9.5
9
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.5
9.0
47
168
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
4.0
8.7
36
107
SPAT1216
SPAT
Assessment of functional ability
3.2
8.7
53
213
F05.9
ICD-10 Finland
Delirium, unspecified
12.6
8.2
14
12
SPAT1234
SPAT
Support of social functional capacity
5.0
8.2
26
59
R56.8
ICD-10 Finland
Other and unspecified convulsions
10.8
7.7
14
14
N06AB10
ATC
escitalopram; oral
3.9
7.6
32
96
N05AH03
ATC
olanzapine; systemic
7.9
7.4
16
22
F01.83
ICD-10 Finland
Other specified vascular dementia other additional symptoms, mainly depression
+∞
7.3
7
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.6
7.3
15
19
N06AB04
ATC
citalopram; systemic
3.0
7.2
46
187
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
5.7
7.2
20
39
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.9
7.0
48
205
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
41.8
6.8
8
*
F05.1
ICD-10 Finland
Delirium superimposed on dementia
41.8
6.8
8
*
P70
ICPC
Dementia
23.6
6.7
9
*
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
5.6
6.5
18
35
N05AD01
ATC
haloperidol; systemic
6.4
6.5
16
27
I95.1
ICD-10 Finland
Orthostatic hypotension
5.2
6.5
19
40
F06.7
ICD-10 Finland
Mild cognitive disorder
8.7
6.5
13
16
N02BE01
ATC
paracetamol; systemic, rectal
2.9
6.4
142
1116
F01.82
ICD-10 Finland
Other specified vascular dementia other additional symptoms, mainly hallucinations
+∞
6.3
6
*
F01.2
ICD-10 Finland
Subcortical vascular dementia
+∞
6.3
6
*
F01.0
ICD-10 Finland
Vascular dementia of acute onset
+∞
6.3
6
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.3
6.3
18
37
U04
ICPC
Incontinence urine
4.7
6.2
20
47
R41.3
ICD-10 Finland
Other amnesia
6.8
6.0
14
22
Mortality – FinRegistry
↥Association
Association between endpoint VD_O and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_O | 2.601 [2.03, 3.34] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 713 out of 1011 females with VD_O died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_O | 3.589 [2.45, 5.26] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 514 out of 719 males with VD_O died.
Mortality risk
Mortality risk for people of age
years, who have VD_O.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.244% | 0.683% |
| 5 | 1.3% | 3.886% |
| 10 | 3.422% | 9.403% |
| 15 | 6.283% | 17.236% |
| 20 | 10.778% | 28.535% |
Relationships between endpoints
↥Index endpoint: VD_O – Vascular dementia (other)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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