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This is a non-core endpoint: only basic statistics are computed.

Benign neoplasm: Central nervous system, other parts/unspecified

CD2_BENIGN_CNS_NOS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D33.7&
  • Hospital discharge: ICD-9 2259
  • Hospital discharge: ICD-8 2259
  • Cause of death: ICD-10 D33.7&
  • Cause of death: ICD-9 2259
  • Cause of death: ICD-8 2259

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D33
Name in latin
Neoplasma benignum alterius partis specificatae systematis nervosi centralis

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 127 63 64
Unadjusted period prevalence (%) 0.02 0.02 0.03
Median age at first event (years) 50.87 50.19 51.55

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
117
Matched controls
1169
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D33.7
ICD-10 Finland
Benign neoplasm: Other specified parts of central nervous system
+∞
110.6
88
*
2259X
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Nervous system, part unspecified
+∞
18.2
17
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
44.7
15.9
19
5
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
9.6
13.4
28
37
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
66.1
10.8
12
*
22599
ICD-8 Finland
Benign neoplasm of brain and other parts of nervous system, Unspecified site
+∞
10.6
10
*
H02AB02
ATC
dexamethasone; systemic
40.0
9.2
11
*
9560/0-C72.9
ICD-O-3
Schwannoma, NOS, of nervous system, NOS
+∞
8.4
8
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
24.0
8.2
11
5
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
13.1
7.8
13
11
D33.30
ICD-10 Finland
Acoustic neuroma
+∞
7.4
7
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
42.5
6.8
8
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
73.6
6.5
7
*
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
73.6
6.5
7
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
6.3
6
*
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
+∞
6.3
6
*
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
+∞
6.3
6
*
D32.1
ICD-10 Finland
Benign neoplasm: Spinal meninges
+∞
6.3
6
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
6.3
6
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
6.7
6.2
15
25

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
25
7.18
10.07
1.3
1.2
—
—
—
0
0
36
167
2.61
5.17
2.4
2.0
2.4
2.4
mmol/l
0.02
29
141
48
257
2.39
5.08
2.8
2.1
—
—
—
0
0
20
68
3.30
4.98
1.2
1.0
—
—
—
0
0
52
299
2.25
4.58
2.4
2.1
2.4
2.3
mmol/l
0.37
43
242
49
283
2.19
4.21
2.3
1.6
—
—
—
0
0
8
12
7.03
3.73
1.9
1.7
—
—
nmol/l
—
0
0
42
239
2.13
3.67
4.9
4.0
—
—
—
0
0
17
63
2.96
3.66
7.9
11.7
1.2
1.6
%
1.00
17
63
17
63
2.96
3.66
8.2
11.7
0.6
0.7
%
0.42
17
63
8
14
6.02
3.40
1.9
1.6
—
—
—
0
0
24
111
2.43
3.39
6.8
12.8
1.2
1.2
mmol/l
0.03
19
92
20
88
2.51
3.13
3.5
3.1
—
—
—
0
0
14
52
2.90
3.00
1.2
1.3
—
—
—
0
0
11
36
3.25
2.88
6.0
4.1
—
—
—
0
0
74
547
1.85
2.85
7.2
6.2
4.4
4.3
e9/l
0.22
66
468
54
371
1.79
2.58
6.5
9.3
1.1
1.3
inr
0.67
14
106
5
7
7.37
2.57
3.6
11.1
7.7
10.5
mg/l
—
5
7
41
259
1.86
2.57
5.0
3.8
0.0
0.0
estimate
0.49
11
77
5
8
6.45
2.39
1.2
1.0
—
—
—
0
0
14
63
2.37
2.10
3.6
11.8
—
—
—
0
0
40
269
1.71
1.98
3.1
3.1
—
—
—
0
0
41
279
1.69
1.94
3.2
3.1
7.4
7.4
ph
—
7
37
33
212
1.75
1.91
1.6
1.7
0.9
1.2
mg/l
0.69
26
168
9
35
2.69
1.84
2.4
1.7
—
—
—
0
0
14
67
2.22
1.84
1.9
1.9
0.2
0.2
g/l
0.16
14
57
14
67
2.22
1.84
1.1
1.1
22.2
102.2
iu/ml
—
5
27
66
513
1.60
1.82
5.7
5.1
0.2
0.2
e9/l
0.55
60
443
91
767
1.66
1.77
5.2
3.8
15.0
14.7
pmol/l
0.48
85
691
16
83
2.06
1.74
9.1
10.6
—
—
—
0
0
64
498
1.57
1.73
5.9
4.9
1.8
1.8
e9/l
0.22
58
436
62
481
1.56
1.69
4.5
3.5
0.0
0.0
estimate
—
10
81
62
483
1.55
1.65
5.3
4.7
0.0
0.0
estimate
0.00
11
80
5
14
3.67
1.63
1.6
1.2
—
—
—
0
0
89
755
1.60
1.60
4.3
3.9
10.7
11.5
mm/h
0.23
83
687
5
15
3.42
1.54
1.2
1.2
—
—
—
0
0
31
209
1.64
1.49
3.9
4.4
—
—
—
0
0
112
1015
1.88
1.48
17.8
11.9
22.1
23.0
mg/l
0.11
93
764
52
399
1.51
1.44
3.9
3.4
62.2
41.9
ng/l
0.27
39
276
78
653
1.50
1.40
4.5
3.9
—
—
—
0
0
61
488
1.48
1.36
4.6
3.5
0.0
0.0
estimate
0.00
11
76
32
223
1.58
1.35
6.5
4.5
—
—
—
0
0
8
34
2.44
1.32
1.6
2.9
—
—
—
0
0
8
34
2.44
1.32
10.1
11.4
—
—
—
0
0
10
48
2.18
1.31
4.6
2.7
24.8
24.4
mmol/l
—
10
48
5
18
2.85
1.29
1.0
1.2
—
—
—
0
0
114
1050
1.84
1.26
21.4
14.7
3.9
4.0
mmol/l
1.21
114
1019
61
494
1.45
1.25
6.0
4.8
0.0
0.0
e9/l
0.75
56
422
43
327
1.48
1.21
3.6
3.6
20.7
112.1
e6/l
1.62
38
223
38
283
1.49
1.18
4.8
3.8
—
—
—
0
0
8
39
2.12
1.17
1.3
1.1
—
—
—
0
0
49
385
1.44
1.16
4.0
3.2
—
—
—
0
0
11
58
1.98
1.16
3.7
1.3
—
—
—
0
0
30
214
1.53
1.14
2.5
1.9
2.9
2.9
mg/l
0.01
25
183
113
1046
1.73
1.11
21.8
14.6
139.6
139.7
mmol/l
0.15
113
1017
7
34
2.12
1.04
1.1
1.1
—
—
—
0
0
9
50
1.86
0.99
2.1
4.3
—
7.4
—
0
6
7
36
2.00
0.98
2.4
4.9
—
—
—
0
0
18
120
1.58
0.91
1.6
1.7
—
—
—
0
0
31
233
1.44
0.91
4.6
3.2
—
—
—
0
0
8
46
1.79
0.84
2.8
1.5
2.3
8.1
ug/l
—
8
38
25
185
1.44
0.80
1.9
1.6
1404.8
1203.6
nmol/l
0.52
20
139
0
24
0.00
0.80
0.0
3.3
—
—
—
0
0
10
59
1.75
0.78
10.2
8.9
26.8
25.3
mmol/l
—
10
59
23
171
1.42
0.72
1.3
1.2
19.2
34.9
iu/ml
—
5
57
5
27
1.89
0.69
4.0
1.9
—
—
—
0
0
7
43
1.66
0.68
1.0
1.1
—
—
—
0
0
14
95
1.53
0.67
1.3
1.3
—
—
—
0
0
19
138
1.44
0.67
1.3
1.2
—
—
—
0
0
5
28
1.82
0.67
1.0
1.1
—
—
—
0
0
79
712
1.29
0.67
3.9
3.7
—
—
—
0
0
21
157
1.40
0.64
1.8
1.8
—
—
—
0
0
7
111
0.61
0.61
1.6
1.4
—
—
—
0
0
0
20
0.00
0.61
0.0
2.2
—
64.9
—
0
20
0
23
0.00
0.59
0.0
1.6
—
128.5
—
0
14
34
279
1.30
0.58
3.6
2.9
18.0
69.8
e6/l
1.25
34
206
5
89
0.54
0.58
1.4
1.1
—
—
—
0
0
99
932
1.28
0.51
6.0
4.5
1.8
1.9
mu/l
0.60
93
837
51
448
1.23
0.50
6.5
5.0
2.4
3.1
%
1.83
46
410
22
174
1.32
0.49
3.6
2.5
515.8
551.8
mosm/kgh2o
0.30
22
141
26
313
0.79
0.46
3.2
4.0
1.4
10.4
mg/mmol
3.01
15
201
33
386
0.80
0.45
2.4
2.9
—
—
—
0
0
7
51
1.39
0.45
5.4
2.1
0.9
0.6
%
—
7
51
5
31
1.64
0.43
1.2
1.4
—
—
—
0
0
5
31
1.64
0.43
1.2
1.4
—
—
—
0
0
5
31
1.64
0.43
1.2
1.4
—
—
—
0
0
8
57
1.43
0.43
2.8
2.2
—
—
—
0
0
5
32
1.58
0.42
1.2
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
15.9
—
0
6
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
12
90
1.37
0.37
1.5
1.4
—
—
—
0
0
89
937
0.83
0.37
17.1
13.3
40.7
40.8
%
0.10
66
690
10
73
1.40
0.35
1.5
1.6
—
—
—
0
0
6
44
1.38
0.35
4.3
3.5
—
—
—
0
0
16
128
1.29
0.34
2.6
2.0
—
—
—
0
0
20
239
0.81
0.33
1.2
1.3
0.8
1.6
u/ml
—
10
63
7
54
1.31
0.31
5.4
2.0
1.5
1.3
%
—
7
54
29
252
1.20
0.31
3.5
2.6
—
—
—
0
0
7
56
1.26
0.30
15.0
19.1
—
—
—
0
0
28
317
0.85
0.27
2.7
3.0
7.2
8.0
mmol/l
0.44
23
265
44
402
1.14
0.26
2.4
1.9
88.0
92.6
pmol/l
0.39
26
210
103
996
1.18
0.25
4.0
4.1
1.2
1.3
mmol/l
0.78
94
917
9
75
1.22
0.25
1.3
1.4
—
—
—
0
0
17
143
1.22
0.25
1.9
1.9
29.6
29.7
s
0.04
17
138
10
124
0.79
0.23
1.6
1.7
—
—
—
0
0
113
1104
1.21
0.22
12.2
8.2
24.0
25.7
u/l
0.62
113
1057
93
897
1.14
0.22
22.6
15.3
332.5
333.1
g/l
0.24
93
892
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
12.0
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
90.9
—
0
12
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
27
242
1.15
0.20
1.5
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
3.8
—
—
—
0
0
27
297
0.88
0.18
2.7
3.2
25.3
278.2
mg/l
0.63
18
192
8
69
1.17
0.17
5.3
3.2
—
—
—
0
0
108
1058
1.14
0.15
4.7
5.0
2.8
2.7
mmol/l
0.07
100
985
32
297
1.10
0.14
7.0
4.9
—
—
—
0
0
9
105
0.85
0.13
2.4
1.5
—
—
—
0
0
23
210
1.12
0.13
3.3
3.4
18.1
121.7
ng/l
2.00
16
160
11
127
0.85
0.13
1.5
1.5
—
—
—
0
0
99
970
1.09
0.11
6.0
5.8
38.9
39.7
mmol/mol
0.38
94
905
25
268
0.92
0.10
5.1
3.3
—
—
—
0
0
5
47
1.07
0.09
1.6
1.1
—
—
—
0
0
105
1034
1.09
0.09
4.4
4.5
4.7
4.6
mmol/l
0.09
97
964
9
83
1.09
0.07
9.2
4.0
—
—
—
0
0
104
1026
1.08
0.07
4.3
4.5
1.5
1.5
mmol/l
0.01
96
950
109
1078
1.08
0.06
16.1
10.7
—
—
—
0
0
44
428
1.04
0.04
11.8
7.4
0.0
0.0
e9/l
0.00
37
330
115
1142
1.07
0.03
26.7
17.1
90.7
90.9
fl
0.14
115
1122
115
1142
1.07
0.03
26.6
17.1
30.3
30.3
pg
0.15
115
1122
115
1143
1.06
0.01
27.0
17.2
136.3
137.5
g/l
0.39
115
1123
11
106
1.04
0.00
2.3
1.8
—
—
—
0
0
11
106
1.04
0.00
1.3
1.4
—
—
—
0
0
21
206
1.02
0.00
3.0
2.5
0.8
0.8
ug/l
0.08
15
126
0
5
0.00
0.00
0.0
1.8
—
2630.0
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
7.0
—
0.7
—
0
6
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
6.5
—
0
7
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
22.7
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
0.00
2.4
2.3
—
—
—
0
0
5
59
0.84
0.00
1.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
33.4
—
0
9

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_BENIGN_CNS_NOS_EXALLC – Benign neoplasm: Central nervous system, other parts/unspecified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).