Benign neoplasm: Central nervous system, other parts/unspecified

CD2_BENIGN_CNS_NOS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D33.7& Hospital discharge: ICD-9 — 2259 Hospital discharge: ICD-8 — 2259 Cause of death: ICD-10 — D33.7& Cause of death: ICD-9 — 2259 Cause of death: ICD-8 — 2259 2 out of 7 registries used, show all original rules.	127
4. Check minimum number of events None	127
5. Include endpoints None	127
6. Filter based on genotype QC (FinnGen only)	127

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D33
Name in latin: Neoplasma benignum alterius partis specificatae systematis nervosi centralis

NAME	CD2_BENIGN_CNS_NOS
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D337
HD_ICD_9	2259
HD_ICD_8	2259
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D337
COD_ICD_9	2259
COD_ICD_8	2259
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Central nervous system, other parts/unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Benign neoplasm: Central nervous system, other parts/unspecified

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1132	596	527
Only index persons	873	465	408
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	48.75	50.58	46.64
Only index persons	46.11	47.21	44.85

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	127	63	64
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	50.87	50.19	51.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
117: Matched controls
1169

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D33.7

ICD-10 Finland

Benign neoplasm: Other specified parts of central nervous system

+∞

110.7

2259X

ICD-9 Finland

Benign neoplasm of brain and other parts of nervous system, Nervous system, part unspecified

+∞

18.2

AAB00

NOMESCO Finland

Extirpation of intracranial lesion

28.0

14.3

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

9.3

13.2

ABB00

NOMESCO Finland

Excision of lesion of spinal canal

+∞

12.7

22599

ICD-8 Finland

Benign neoplasm of brain and other parts of nervous system, Unspecified site

+∞

10.6

9560/0-C72.9

ICD-O-3

Schwannoma, NOS, of nervous system, NOS

+∞

8.4

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

14.4

8.1

XCK00

NOMESCO Finland

Perimetry

6.2

6.6

D32.02

ICD-10 Finland

Benign tumor of the meninges at the base of the brain

73.7

6.5

G91.1

ICD-10 Finland

Obstructive hydrocephalus

+∞

6.3

D33.00

ICD-10 Finland

Medial pilosytic astrocytoma of the cerebrum

+∞

6.3

D33.07

ICD-10 Finland

Colloid coast in cerebral ventricle

+∞

6.3

D32.1

ICD-10 Finland

Benign neoplasm: Spinal meninges

+∞

6.3

D33.9

ICD-10 Finland

Benign neoplasm: Central nervous system, unspecified

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

179

2.41

4.41

2.4

2.5

2.4

2.5

mmol/l

0.81

154

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

138

2.32

3.45

4.6

7.7

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

5.61

3.24

1.9

1.6

—

nmol/l

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

339

1.90

3.03

2.4

3.5

2.4

mmol/l

0.25

287

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

4.94

2.97

1.9

1.5

—

(3003396) Base excess in Arterial blood by calculation

118

2.27

2.96

6.8

13.5

1.2

1.7

mmol/l

0.29

(3044640) Blood type and Crossmatch panel - Blood

318

1.82

2.58

2.8

2.5

—

(3020891) Body temperature

2.99

2.54

6.0

4.8

—

(40761535) Cells panel - Urine sediment

2.26

2.54

3.5

3.3

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.81

2.41

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

224

1.85

2.34

2.4

2.5

—

(3025941) Bacteria identified in Stool by Culture

2.50

2.31

1.2

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

445

1.71

2.30

4.9

4.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

483

1.71

2.29

8.2

9.1

1.2

mmol/l

0.02

406

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

3.49

2.22

1.3

1.1

—

(3016502) Oxygen saturation in Arterial blood

104

2.10

2.15

7.4

14.7

94.4

95.8

0.27

(3023368) Bacteria identified in Blood by Culture

281

1.74

2.13

4.9

4.3

—

(3000093) Morphology [Interpretation] in Blood Narrative

5.15

2.09

1.2

1.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

759

1.70

1.93

5.2

3.9

15.0

14.7

pmol/l

0.49

675

(3045414) Leukocytes [Presence] in Urine

2.69

1.84

2.4

1.5

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

4.29

1.84

1.6

1.2

—

(4034850)

2.87

1.82

10.1

15.2

—

(3032080) INR in Blood by Coagulation assay

400

1.61

1.82

6.5

9.2

1.1

1.3

inr

0.41

120

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

2.19

1.78

1.1

22.2

129.6

iu/ml

—

(3000991) Gas panel - Venous blood

2.06

1.74

9.1

10.3

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.68

1.69

1.3

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

291

1.60

1.62

5.0

3.9

0.0

estimate

0.49

(3013650) Neutrophils [#/volume] in Blood by Automated count

603

1.54

1.59

7.2

9.5

4.4

4.2

e9/l

0.27

536

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

224

1.64

1.55

1.6

1.8

0.9

1.4

mg/l

1.03

185

(3002256) Pathology report gross observation

118

1.82

1.52

1.2

1.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.58

1.47

1.1

2.3

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.58

1.47

2.6

0.0

g/l

—

(3019060) Gas panel - Arterial blood

2.00

1.45

3.6

10.7

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

112

1020

1.83

1.38

17.8

14.4

22.1

23.6

mg/l

0.19

799

(3044290) Cell count panel - Cerebral spinal fluid

3.02

1.37

1.0

1.8

—

(3013115) Eosinophils [#/volume] in Blood

536

1.48

1.37

5.7

5.9

0.2

e9/l

0.26

478

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

403

1.49

1.36

3.9

3.7

62.2

30.5

ng/l

0.48

291

(3013707) Erythrocyte sedimentation rate by Westergren method

769

1.53

1.35

4.3

4.1

10.7

12.4

mm/h

0.58

696

(3052851) Hemolysis interference index of Serum or Plasma

2.44

1.32

1.6

3.4

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

114

1048

1.86

1.30

21.4

16.7

3.9

4.0

mmol/l

1.00

114

1015

(3019198) Lymphocytes [#/volume] in Blood

525

1.44

1.22

5.9

5.6

1.8

2.0

e9/l

0.55

472

(40768443) Skin Pathology biopsy report

2.18

1.21

1.3

—

(40768804) Tissue Pathology biopsy report

383

1.45

1.20

2.3

2.1

—

(3018418) pH of Serum or Plasma

310

1.48

1.19

3.2

4.3

7.4

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

113

1043

1.76

1.17

21.8

16.6

139.6

mmol/l

0.05

113

1011

(4035726)

1.76

1.17

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

357

1.45

1.16

3.5

3.1

—

(3026008) Bacteria identified in Urine by Culture

302

1.47

1.16

3.1

3.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.25

1.10

1.1

1.2

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.00

1.09

4.6

4.1

24.8

24.4

mmol/l

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.18

1.07

1.1

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.18

1.07

1.1

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

516

1.39

1.04

4.5

3.7

0.0

estimate

—

(3013512) EKG study

291

1.44

1.02

4.8

4.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

518

1.38

1.01

5.3

5.1

0.0

estimate

0.00

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.99

0.0

2.2

—

126.5

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

340

0.67

0.98

2.5

3.2

29.8

31.7

u/l

0.25

323

(3022313) Gas panel - Capillary blood

1.94

0.95

2.4

4.5

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.20

0.93

1.7

1.1

—

(3006315) Basophils [#/volume] in Blood

515

1.35

0.91

6.0

5.6

0.0

e9/l

0.10

454

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.92

0.89

2.6

2.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

686

1.36

0.88

4.5

4.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

228

1.41

0.83

2.5

2.0

2.9

3.1

mg/l

0.17

203

(3007853) Bacteria identified in Skin by Aerobe culture

123

1.54

0.83

1.6

1.7

—

(3009261) Glucose [Presence] in Urine by Test strip

522

1.32

0.80

4.6

3.7

0.0

estimate

0.00

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.80

0.0

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

177

1.44

0.78

1.4

1.8

—

(3018095) Leukocytes [#/volume] in Urine

351

1.34

0.78

3.6

3.7

20.7

67.5

e6/l

1.65

249

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.22

0.77

1.0

1.6

—

(3009343) pH of Capillary blood

1.72

0.76

2.1

4.0

—

7.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.68

0.75

1.1

1.3

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.89

0.75

2.6

2.4

2.8

3.2

g/l

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.89

0.75

2.6

1.8

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.72

0.74

10.2

7.2

26.8

25.4

mmol/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

170

1.43

0.74

1.3

1.2

19.2

37.6

iu/ml

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

1.70

0.69

2.3

1.9

1.0

7.5

ug/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

245

1.35

0.69

3.9

4.5

—

(3037756) Immunofixation for Serum or Plasma

1.82

0.67

1.2

1.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.75

0.64

1.4

1.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

193

1.37

0.64

1.9

1.7

1404.8

1275.1

nmol/l

0.30

141

(3011397) Hemoglobin [Presence] in Urine by Test strip

248

1.33

0.63

4.6

3.5

—

(3000764) Benzodiazepines [Presence] in Urine

1.69

0.62

1.2

1.4

—

(3027008) Opiates [Presence] in Urine

1.69

0.62

1.2

1.4

—

(3028300) Cannabinoids [Presence] in Urine

1.69

0.62

1.2

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.58

0.61

3.7

2.6

—

(3024928) Oxygen saturation in Venous blood

0.00

0.61

0.0

3.7

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.61

0.0

1.0

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.61

0.0

1.1

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.61

0.0

1.3

—

1.6

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.60

0.0

2.2

—

136.6

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.60

0.0

2.8

—

16.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.54

0.59

1.1

1.5

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.59

0.0

1.4

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.59

0.0

1.2

—

4.8

—

(3044889) 12 lead EKG panel

720

1.26

0.57

3.9

3.8

—

(40758558) Short blood count panel - Blood

262

1.30

0.56

6.5

7.0

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

928

1.30

0.55

6.0

4.6

1.8

1.9

mu/l

0.64

820

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

126

1.40

0.55

1.4

1.7

—

(40768797) Stomach Pathology biopsy report

144

1.38

0.54

1.3

1.2

—

(3008898) HLA-B27 [Presence]

1.59

0.50

1.0

1.1

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

102

1.42

0.50

1.9

2.6

0.2

g/l

0.02

(1761868) Lipid panel - Serum or Plasma

389

0.80

0.49

2.4

2.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

152

0.70

0.47

1.5

—

(36660697) Celiac disease serology panel - Serum

0.57

0.47

1.4

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

130

0.67

0.46

2.4

1.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.41

0.46

4.2

3.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

131

1.34

0.45

1.5

1.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

943

0.81

0.44

17.1

15.2

40.7

40.3

0.29

683

(3027944) Amphetamines [Presence] in Urine

1.64

0.43

1.2

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

415

1.21

0.43

5.1

3.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

652

1.20

0.43

3.4

3.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.54

0.42

3.0

1.6

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.41

0.0

1.8

—

32.1

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.41

0.0

2.5

—

61.4

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.41

0.0

2.1

—

88.7

—

(21494755) Public health laboratory ask at order entry panel

105

0.65

0.41

1.6

1.4

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(4306422)

0.00

0.41

0.0

1.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.49

0.41

2.0

1.9

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.40

0.0

1.2

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.40

0.0

1.0

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.45

0.40

1.0

1.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.45

0.40

1.2

2.0

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.39

0.0

1.5

—

(4268621)

0.00

0.39

0.0

2.1

—

(3049717) Cytology report of Urine Cyto stain

1.40

0.38

4.0

2.7

—

(3000494) Fungus identified in Specimen by Culture

134

0.72

0.37

1.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

242

0.79

0.37

1.2

1.3

0.8

1.5

u/ml

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.62

0.37

1.0

1.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

173

1.26

0.36

2.1

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

103

987

1.23

0.35

4.0

4.1

1.2

1.3

mmol/l

0.77

892

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.35

0.35

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

303

0.82

0.34

3.2

4.0

1.4

9.3

mg/mmol

3.17

193

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

193

1.23

0.34

3.3

3.4

18.1

174.1

ng/l

1.84

147

(3022145) Colonoscopy Study observation

110

1.31

0.33

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

395

1.17

0.33

2.4

2.0

88.0

91.0

pmol/l

0.23

201

(3041096) Erythrocytes [Presence] in Urine by Automated

290

0.83

0.31

5.1

3.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.36

0.31

1.5

1.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

108

1044

1.23

0.30

4.7

5.0

2.8

2.7

mmol/l

0.11

100

954

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.29

0.30

5.4

2.5

1.5

1.4

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

108

0.72

0.30

2.8

4.0

2.3

51.3

ug/l

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.26

0.30

15.0

18.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

177

1.22

0.30

1.8

1.7

—

(3022621) pH of Urine by Test strip

1.27

0.28

2.8

2.1

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

113

1100

1.25

0.27

12.2

10.3

24.0

25.7

u/l

0.65

113

1051

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

100

965

1.17

0.25

18.4

12.9

81.7

80.9

ml/min/173m2

0.14

774

(4010399)

1.20

0.25

1.3

1.4

—

(3002582) Erythrocytes [#/volume] in Urine

306

1.15

0.24

3.6

3.1

18.0

47.2

e6/l

0.94

235

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

156

0.81

0.23

2.8

2.9

6.5

3.2

e6/l

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

105

1020

1.17

0.22

4.4

4.5

4.7

4.6

mmol/l

0.16

937

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

145

0.81

0.22

1.5

1.4

—

(3036489) Thrombin time

1.20

0.21

1.0

2.0

26.4

20.7

—

(3044941) Cell count panel - Synovial fluid

0.00

0.21

0.0

1.1

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.6

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

2.1

—

15.9

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3028308) Erythrocytes [#/volume] in Pleural fluid

0.00

0.21

0.0

1.3

—

19596.0

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(4027681)

0.00

0.21

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.1

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

3.3

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.5

—

(3006504) Eosinophils/100 leukocytes in Blood

476

1.12

0.21

6.5

5.7

2.4

2.8

0.64

438

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.0

—

(3000330) Specific gravity of Urine by Test strip

1.21

0.20

4.3

4.4

—

(3009508) Creatinine [Moles/volume] in Urine

306

0.89

0.16

2.7

3.0

7.2

7.8

mmol/l

0.34

254

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

965

1.12

0.16

6.0

5.7

38.9

39.8

mmol/mol

0.46

889

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.17

0.16

2.1

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

102

1.19

0.16

1.5

1.9

—

(3026782) Osmolality of Urine

198

1.13

0.15

3.6

2.9

515.8

555.0

mosm/kgh2o

0.34

169

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

104

1017

1.12

0.15

4.3

4.5

1.5

mmol/l

0.03

924

(36304419) Bacteria [Presence] in Urine

269

1.10

0.13

3.5

2.8

—

(3024731) MCV [Entitic volume]

115

1133

1.16

0.12

26.7

20.7

90.7

91.1

0.37

115

1114

(3035941) MCH [Entitic mass]

115

1133

1.16

0.12

26.6

20.7

30.3

0.22

115

1114

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

163

1.12

0.11

2.2

2.7

0.4

1.1

e6/l

1.54

(3000963) Hemoglobin [Mass/volume] in Blood

115

1134

1.15

0.11

27.0

20.9

136.3

135.9

g/l

0.12

115

1112

(3003694) ABO and Rh group [Type] in Blood

251

1.10

0.11

1.5

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

419

1.08

0.11

2.8

2.4

75.5

75.3

nmol/l

0.02

369

(1002224) Polysomnography panel

1.12

0.10

1.6

1.2

—

(40761511) CBC panel - Blood by Automated count

109

1074

1.11

0.09

16.1

13.4

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.14

0.09

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

107

1.13

0.09

1.7

1.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.83

0.08

1.5

—

(3019225) pH of Specimen

1.09

0.07

9.2

5.7

—

(3012516) Albumin [Mass/volume] in Urine

284

0.94

0.06

2.7

3.2

25.3

280.9

mg/l

0.60

184

(3042936) Bacteria identified in Isolate by Culture

149

1.08

0.05

2.6

2.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

100

1.11

0.05

2.3

1.8

—

(3000492) Spirometry study

101

1.10

0.04

1.3

1.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

291

1.00

0.00

4.6

4.3

21.2

21.6

0.06

137

(42870588) Differential panel, method unspecified - Blood

323

0.99

0.00

7.0

5.5

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

212

0.99

0.00

3.0

2.7

0.8

0.9

ug/l

0.15

123

(3021589) Normoblasts [#/volume] in Blood

436

1.01

0.00

11.8

10.0

0.0

e9/l

0.71

353

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

6.5

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.4

—

18.4

—

(44806071)

0.00

0.0

1.2

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

6.1

—

0.6

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

1.8

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.1

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.2

—

197.6

—

(3017704) Immunofixation for Urine

0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

1.1

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.1

—

(3000012) Reticulocyte production index

0.00

0.0

1.4

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.96

0.00

2.4

2.1

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.96

0.00

1.0

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

30.4

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.5

—

12.9

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(40761536) Microorganisms panel - Urine sediment

0.95

0.00

5.3

3.3

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.98

0.00

1.3

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.5

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.4

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

4.7

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.3

—

14.3

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.00

0.00

1.4

1.8

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.2

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.4

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

12.8

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.8

—

77.0

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_CNS_NOS and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_CNS_NOS	1.387 [1.01, 1.9]	0.041
Birth year	1.001 [0.99, 1.01]	0.808

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 315 females with CD2_BENIGN_CNS_NOS died.

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_CNS_NOS	1.853 [1.28, 2.68]	0.001
Birth year	0.989 [0.98, 1.0]	0.022

During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 283 males with CD2_BENIGN_CNS_NOS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CNS_NOS.

N-year risk	Females	Males
1	0.154%	0.343%
5	0.934%	2.159%
10	2.392%	5.722%
15	4.796%	10.819%
20	8.598%	17.648%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_CNS_NOS – Benign neoplasm: Central nervous system, other parts/unspecified

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Central nervous system, other parts/unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints