Benign neoplasm: Central nervous system, other parts/unspecified

CD2_BENIGN_CNS_NOS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D33.7& Hospital discharge: ICD-9 — 2259 Hospital discharge: ICD-8 — 2259 Cause of death: ICD-10 — D33.7& Cause of death: ICD-9 — 2259 Cause of death: ICD-8 — 2259 2 out of 7 registries used, show all original rules.	134
4. Check minimum number of events None	134
5. Include endpoints None	134
6. Filter based on genotype QC (FinnGen only)	131

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D33
Name in latin: Neoplasma benignum alterius partis specificatae systematis nervosi centralis

NAME	CD2_BENIGN_CNS_NOS
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D337
HD_ICD_9	2259
HD_ICD_8	2259
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D337
COD_ICD_9	2259
COD_ICD_8	2259
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Central nervous system, other parts/unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1132	596	527
Only index persons	873	465	408
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	48.75	50.58	46.64
Only index persons	46.11	47.21	44.85

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	131	67	64
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	50.72	51.40	50.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
134: Matched controls
1340

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D33.7

ICD-10 Finland

Benign neoplasm: Other specified parts of central nervous system

+∞

133.7

105

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

7.6

21.9

2259X

ICD-9 Finland

Benign neoplasm of brain and other parts of nervous system, Nervous system, part unspecified

+∞

18.1

AAB00

NOMESCO Finland

Extirpation of intracranial lesion

33.2

15.7

ABB00

NOMESCO Finland

Excision of lesion of spinal canal

+∞

13.8

XCK00

NOMESCO Finland

Perimetry

6.1

11.5

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

12.8

11.0

22599

ICD-8 Finland

Benign neoplasm of brain and other parts of nervous system, Unspecified site

+∞

10.6

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

28.5

10.0

AAB10

NOMESCO Finland

Partial excision of intracranial lesion

32.7

9.6

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

5.7

9.4

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

4.3

9.0

D43.0

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Brain, supratentorial

95.8

8.5

D33.30

ICD-10 Finland

Acoustic neuroma

95.8

8.5

9560/0-C72.9

ICD-O-3

Schwannoma, NOS, of nervous system, NOS

+∞

8.4

D33.00

ICD-10 Finland

Medial pilosytic astrocytoma of the cerebrum

+∞

7.4

9530/0-C70.0

ICD-O-3

Meningioma, NOS, of cerebral meninges

23.9

6.8

D33.07

ICD-10 Finland

Colloid coast in cerebral ventricle

73.2

6.5

2152

FHL

Extraction, big brain

+∞

6.3

D33.9

ICD-10 Finland

Benign neoplasm: Central nervous system, unspecified

+∞

6.3

D32.1

ICD-10 Finland

Benign neoplasm: Spinal meninges

+∞

6.3

N03AF01

ATC

carbamazepine; oral, rectal

4.3

6.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

189

2.41

4.64

2.6

2.5

2.43

2.46

mmol/l

0.60

162

(3003396) Base excess in Arterial blood by calculation

120

2.57

4.15

6.6

13.3

1.00

1.71

mmol/l

0.52

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

140

2.37

3.73

4.6

7.7

—

(3016502) Oxygen saturation in Arterial blood

105

2.44

3.32

7.1

14.6

95.13

95.75

0.13

100

(3044640) Blood type and Crossmatch panel - Blood

331

1.93

3.25

2.7

2.5

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

136

2.23

3.13

7.4

8.4

104.59

103.61

mmol/l

0.40

136

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

5.24

3.10

1.9

1.6

—

nmol/l

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

360

1.84

2.86

2.6

3.6

2.37

2.35

mmol/l

0.32

311

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

234

1.94

2.85

2.4

2.6

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

4.65

2.84

1.9

1.5

—

(3020891) Body temperature

3.19

2.78

5.8

4.7

—

(3022217) INR in Platelet poor plasma by Coagulation assay

490

1.79

2.76

11.9

14.0

1.18

1.27

inr

0.33

135

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

463

1.78

2.74

3.0

2.9

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.94

2.72

1.3

1.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

3.78

2.63

1.2

1.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

516

1.75

2.57

8.0

9.1

1.21

mmol/l

0.21

442

(3000991) Gas panel - Venous blood

2.24

2.41

8.6

11.0

—

(40761535) Cells panel - Urine sediment

100

2.18

2.35

3.5

3.3

—

(3023368) Bacteria identified in Blood by Culture

290

1.77

2.35

4.7

4.5

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

2.35

2.32

1.2

1.1

25.87

125.84

iu/ml

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

807

1.73

2.11

5.1

3.8

14.93

14.67

pmol/l

0.49

722

(3044290) Cell count panel - Cerebral spinal fluid

3.63

2.08

1.0

3.1

—

(3025941) Bacteria identified in Stool by Culture

2.33

2.02

1.2

1.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

236

1.72

1.93

1.8

2.1

0.83

1.37

mg/l

1.11

194

(3013650) Neutrophils [#/volume] in Blood by Automated count

645

1.60

1.86

7.0

9.8

4.34

4.16

e9/l

0.29

572

(40768804) Tissue Pathology biopsy report

406

1.60

1.86

2.3

2.1

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

4.28

1.84

1.4

1.2

—

(3000093) Morphology [Interpretation] in Blood Narrative

4.28

1.84

1.2

1.3

—

(3019060) Gas panel - Arterial blood

2.13

1.77

3.6

10.6

—

(3013115) Eosinophils [#/volume] in Blood

573

1.55

1.73

5.6

6.4

0.18

0.19

e9/l

0.27

512

(3013707) Erythrocyte sedimentation rate by Westergren method

816

1.62

1.72

4.3

4.1

10.73

12.17

mm/h

0.50

742

(4034850) Laboratory test

2.59

1.62

10.1

14.4

—

(3026008) Bacteria identified in Urine by Culture

317

1.58

1.61

3.2

3.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

418

1.54

1.59

3.8

3.6

59.44

29.92

ng/l

0.47

301

(3003327) Ova and parasites identified in Stool by Light microscopy

2.51

1.56

1.3

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

302

1.57

1.55

4.9

3.9

0.00

0.01

estimate

0.49

(3019198) Lymphocytes [#/volume] in Blood

563

1.51

1.54

5.8

6.0

1.77

2.00

e9/l

0.57

511

(3002256) Pathology report gross observation

126

1.79

1.51

1.1

1.3

—

(3045414) Leukocytes [Presence] in Urine

2.53

1.51

2.4

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

119

1083

1.88

1.51

17.4

14.3

21.71

23.13

mg/l

0.20

837

(3023103) Potassium [Moles/volume] in Serum or Plasma

121

1110

1.93

1.44

21.2

16.7

3.94

3.97

mmol/l

0.87

121

1077

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.49

1.41

2.6

0.00

g/l

—

(3052851) Hemolysis interference index of Serum or Plasma

2.37

1.29

1.6

3.1

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

120

1106

1.81

1.29

21.7

16.6

139.63

139.57

mmol/l

0.10

120

1074

(3013512) EKG study

297

1.49

1.25

4.7

4.0

—

(3001604) Monocytes [#/volume] in Blood

551

1.43

1.24

5.9

0.57

0.58

e9/l

0.19

489

(3035637) Corticotropin [Mass/volume] in Plasma

2.69

1.22

1.4

1.5

—

(3006315) Basophils [#/volume] in Blood

552

1.43

1.22

5.9

0.04

e9/l

0.28

487

(40768443) Skin Pathology biopsy report

2.12

1.17

1.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.40

1.14

1.1

2.8

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

182

1.53

1.06

1.2

19.20

35.18

iu/ml

—

(3018418) pH of Serum or Plasma

334

1.42

1.06

3.3

4.1

7.40

—

(4035726) Immunohistochemistry procedure

1.70

1.05

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.12

1.04

1.1

1.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.84

1.04

9.8

8.8

26.24

25.33

mmol/l

0.39

(3035350) Ketones [Presence] in Urine by Test strip

544

1.38

1.03

4.5

3.8

0.00

estimate

-0.00

100

(42529406) Shigella sp [Presence] in Stool by Culture

2.05

1.01

1.1

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.05

1.01

1.1

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

546

1.37

1.00

5.4

5.1

0.00

estimate

-0.00

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

384

1.39

0.99

3.4

3.3

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.92

0.99

4.6

4.0

24.78

24.35

mmol/l

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.99

0.0

2.2

—

126.50

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.19

0.93

1.7

1.1

—

(3019309) Folate [Moles/volume] in Red Blood Cells

197

1.46

0.92

1.9

1.7

1373.50

1259.57

nmol/l

0.27

145

(40760892) CBC W Ordered Manual Differential panel - Blood

515

1.34

0.88

6.0

6.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

725

1.34

0.86

4.5

4.2

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.83

0.86

2.6

2.2

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

364

0.71

0.84

2.5

3.3

29.14

31.74

u/l

0.39

347

(3022313) Gas panel - Capillary blood

1.79

0.84

2.3

5.1

—

(3044889) 12 lead EKG panel

757

1.34

0.84

3.8

—

(3008898) HLA-B27 [Presence]

1.75

0.82

1.0

1.1

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.80

0.0

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

551

1.31

0.79

4.5

3.7

0.00

estimate

-0.00

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.78

0.0

1.8

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

1.80

0.77

2.7

3.6

204.67

193.82

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.22

0.77

1.0

1.6

—

(3014051) Protein [Presence] in Urine by Test strip

2.12

0.75

3.8

1.5

—

(3018095) Leukocytes [#/volume] in Urine

381

1.32

0.74

3.5

4.0

19.38

61.63

e6/l

1.63

275

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

1.66

0.68

2.3

1.9

0.96

7.32

ug/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

129

1.46

0.68

1.6

1.7

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

237

1.34

0.66

2.5

2.0

2.91

3.04

mg/l

0.13

211

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.62

0.66

2.4

1.9

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

183

1.38

0.65

1.4

1.8

—

(3037756) Immunofixation for Serum or Plasma

1.75

0.64

1.2

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

266

1.32

0.64

4.6

3.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

161

0.65

0.61

1.5

—

(21494755) Public health laboratory ask at order entry panel

113

0.60

0.61

1.6

1.4

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.60

0.0

1.0

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.60

0.0

2.1

—

136.57

—

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.59

0.0

2.7

—

16.46

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.75

0.58

1.2

2.0

—

(40768797) Stomach Pathology biopsy report

151

1.38

0.58

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

105

985

1.30

0.58

6.0

4.6

1.75

1.93

mu/l

0.84

876

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

431

1.26

0.58

5.0

3.8

—

(3009343) pH of Capillary blood

1.58

0.57

2.0

4.6

—

7.44

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.54

0.56

1.1

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.53

0.55

3.7

2.6

—

(3002385) Erythrocyte distribution width [Ratio]

929

1.25

0.50

18.6

17.8

16.18

14.53

1.27

919

(3036489) Thrombin time

1.52

0.48

2.6

2.9

25.71

21.02

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.59

0.47

1.0

1.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

112

1.38

0.47

1.5

1.9

—

(40758558) Short blood count panel - Blood

288

1.24

0.45

6.4

7.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

131

1.34

0.45

1.4

1.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

413

1.21

0.44

2.4

2.0

88.24

92.33

pmol/l

0.36

212

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.48

0.44

1.1

1.5

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.46

0.43

5.0

2.5

0.81

0.69

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.64

0.43

1.4

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.43

0.43

5.0

2.5

1.41

1.36

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.43

0.43

13.3

18.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

109

1040

1.26

0.42

4.2

4.0

1.22

1.26

mmol/l

0.46

100

943

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.53

0.42

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

137

0.71

0.41

2.3

1.5

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.41

0.0

2.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.41

0.0

1.8

—

32.13

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

106

1.36

0.41

1.5

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(3027008) Opiates [Presence] in Urine

1.49

0.41

1.2

1.4

—

(3000764) Benzodiazepines [Presence] in Urine

1.49

0.41

1.2

1.4

—

(3028300) Cannabinoids [Presence] in Urine

1.49

0.41

1.2

1.4

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.40

0.0

1.2

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.8

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.40

0.0

2.0

—

89.45

—

(3027944) Amphetamines [Presence] in Urine

1.44

0.39

1.2

1.4

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.44

0.39

2.0

1.9

—

(3000012) Reticulocyte production index

0.00

0.39

0.0

1.8

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.39

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.39

0.0

1.6

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.39

0.0

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

707

1.17

0.36

3.5

3.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

191

1.25

0.36

1.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

136

1.29

0.36

1.5

1.8

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

109

1.32

0.35

1.9

2.6

0.22

g/l

0.02

(1761868) Lipid panel - Serum or Plasma

406

0.85

0.33

2.4

2.8

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

120

1165

1.29

0.33

12.2

10.3

24.13

25.75

u/l

0.64

120

1116

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

194

1.22

0.32

2.0

1.5

—

(3000494) Fungus identified in Specimen by Culture

141

0.76

0.31

1.5

1.6

—

(3000330) Specific gravity of Urine by Test strip

1.31

0.31

4.0

4.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

114

1103

1.22

0.31

4.9

2.78

2.75

mmol/l

0.17

106

1012

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

173

0.79

0.30

2.8

3.3

5.78

2.87

e6/l

—

100

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

446

1.16

0.30

2.7

2.5

76.13

75.26

nmol/l

0.12

395

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

205

1.21

0.30

3.3

3.4

17.18

168.32

ng/l

1.87

153

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

105

1011

1.18

0.28

6.0

5.5

38.95

39.68

mmol/mol

0.36

100

932

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

106

1022

1.18

0.28

18.0

12.7

81.82

81.42

ml/min/173m2

0.07

822

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

104

1.28

0.27

4.2

3.5

—

(3022621) pH of Urine by Test strip

1.21

0.27

2.8

2.1

—

(3003694) ABO and Rh group [Type] in Blood

265

1.17

0.26

1.5

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

264

0.84

0.26

1.2

1.3

0.85

1.50

u/ml

0.80

(3020682) Albumin/Creatinine [Ratio] in Urine

315

0.86

0.25

3.2

3.8

1.52

8.97

mg/mmol

3.08

201

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

111

1077

1.18

0.25

4.6

4.5

4.69

4.64

mmol/l

0.21

103

993

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.33

0.23

3.0

1.7

—

(3049717) Cytology report of Urine Cyto stain

1.29

0.23

4.0

2.6

—

(36660697) Celiac disease serology panel - Serum

0.72

0.23

1.3

1.2

—

(3022145) Colonoscopy Study observation

116

1.23

0.23

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.29

0.23

1.5

1.6

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.26

0.22

1.0

1.2

—

(3026782) Osmolality of Urine

211

1.17

0.22

3.5

3.2

490.37

541.78

mosm/kgh2o

0.60

180

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

2.0

—

15.68

—

(3028308) Erythrocytes [#/volume] in Pleural fluid

0.00

0.21

0.0

1.3

—

19596.00

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.21

0.0

1.3

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.1

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3044941) Cell count panel - Synovial fluid

0.00

0.21

0.0

1.2

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

113

0.78

0.21

2.6

4.0

2.20

48.68

ug/l

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.5

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.20

0.0

1.3

—

(3002582) Erythrocytes [#/volume] in Urine

332

1.12

0.17

3.5

3.4

17.48

43.50

e6/l

0.91

258

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

110

1074

1.14

0.17

4.5

4.4

1.46

mmol/l

0.02

102

980

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

177

1.15

0.17

1.3

1.2

1.38

8.30

u/ml

—

(36304419) Bacteria [Presence] in Urine

294

1.12

0.16

3.4

3.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.12

0.15

2.1

1.4

—

(3024731) MCV [Entitic volume]

122

1201

1.18

0.15

26.4

20.7

90.72

90.95

0.26

122

1182

(3035941) MCH [Entitic mass]

122

1201

1.18

0.15

26.3

20.7

30.26

30.31

0.12

122

1182

(4200892) Spirometry reversibility

1.21

0.14

1.3

1.4

—

(3000963) Hemoglobin [Mass/volume] in Blood

122

1202

1.17

0.13

26.7

20.9

136.19

135.87

g/l

0.09

122

1180

(3009508) Creatinine [Moles/volume] in Urine

322

0.91

0.12

2.8

3.5

7.18

7.81

mmol/l

0.38

270

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

114

1.16

0.12

1.5

2.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

301

0.91

0.12

4.8

3.5

—

(40761511) CBC panel - Blood by Automated count

115

1134

1.10

0.09

16.0

13.1

—

(3000492) Spirometry study

107

1.13

0.09

1.4

1.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.06

0.08

1.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.80

0.08

1.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.05

0.08

1.3

—

(3021589) Normoblasts [#/volume] in Blood

473

1.06

0.07

11.1

10.2

0.00

e9/l

0.71

385

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.06

0.07

1.4

1.5

—

(3019225) pH of Specimen

1.06

0.07

9.2

5.6

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

182

1.05

0.02

2.2

3.1

0.54

1.03

e6/l

0.95

107

(3012516) Albumin [Mass/volume] in Urine

296

0.97

0.00

2.8

3.2

25.39

270.27

mg/l

0.61

194

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

101

0.99

0.00

1.4

2.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

153

0.98

0.00

1.4

1.5

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

213

0.98

0.00

3.0

2.7

0.83

0.94

ug/l

0.14

124

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

292

0.99

0.00

4.6

4.3

21.20

21.59

0.06

137

(3042936) Bacteria identified in Isolate by Culture

158

1.01

0.00

2.6

2.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

105

1.05

0.00

2.1

1.7

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.4

—

18.40

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

2.2

—

5.98

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

0.0

1.2

—

1.20

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

1.8

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

0.0

6.1

—

0.57

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.5

—

(3042891) Cardiolipin IgM Ab [Mass/volume] in Serum

0.00

0.0

1.2

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.3

—

14.33

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.0

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

12.8

—

(3017704) Immunofixation for Urine

0.00

0.0

1.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.8

—

77.00

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3036185) Alkaline phosphatase.liver 2 [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.3

—

18.62

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

6.50

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3035062) Alkaline phosphatase.liver 1 [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.3

—

43.85

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.3

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.2

—

197.62

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

73.71

—

(3036603) Volume of Urine

0.00

-0.00

0.0

1.1

—

1957.14

—

(1002224) Polysomnography panel

1.00

-0.00

1.6

1.2

—

(40761536) Microorganisms panel - Urine sediment

0.91

-0.00

5.0

3.3

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

29.50

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.91

-0.00

2.4

2.1

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.4

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.6

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.0

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

4.7

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_CNS_NOS and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_CNS_NOS	1.387 [1.01, 1.9]	0.041
Birth year	1.001 [0.99, 1.01]	0.808

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 315 females with CD2_BENIGN_CNS_NOS died.

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_CNS_NOS	1.853 [1.28, 2.68]	0.001
Birth year	0.989 [0.98, 1.0]	0.022

During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 283 males with CD2_BENIGN_CNS_NOS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CNS_NOS.

N-year risk	Females	Males
1	0.154%	0.343%
5	0.934%	2.159%
10	2.392%	5.722%
15	4.796%	10.819%
20	8.598%	17.648%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_CNS_NOS – Benign neoplasm: Central nervous system, other parts/unspecified

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Central nervous system, other parts/unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints