Cytomegaloviral hepatitis

CMV_HEPATITIS

animal viral hepatitis: A hepatitis that involves viral infection of an animal causing inflammation of the liver.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B25.1+, B25.1+K77.0 Hospital discharge: ICD-9 — 0785B Cause of death: ICD-10 — B25.1+, B25.1+K77.0 Cause of death: ICD-9 — 0785B 2 out of 7 registries used, show all original rules.	94
4. Check minimum number of events None	94
5. Include endpoints None	94
6. Filter based on genotype QC (FinnGen only)	94

Control definitions (FinnGen only)

Control exclude: IBD_CMV

Extra metadata

First used in FinnGen datafreeze: DF2

NAME	CMV_HEPATITIS
CONTROL_EXCLUDE	IBD_CMV
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B251
HD_ICD_9	0785B
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B251
COD_ICD_9	0785B
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Cytomegaloviral hepatitis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	572	309	258
Only index persons	496	268	228
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	39.29	44.09	33.25
Only index persons	38.68	43.17	33.39

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	94	60	34
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	44.05	46.57	39.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
83: Matched controls
827

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K77.0*B25.1

ICD-10 Finland

Cytomegaloviral hepatitis

+∞

55.6

B25.1

ICD-10 Finland

Cytomegaloviral hepatitis

+∞

20.7

0785B

ICD-9 Finland

Other diseases due to viruses and Chlamydiae, Cytomegaloviral disease[HEPATITIS CYTOMEGALICA]

+∞

17.3

R50.9

ICD-10 Finland

Fever, unspecified

9.1

15.3

K75.9

ICD-10 Finland

Inflammatory liver disease, unspecified

97.4

15.2

L04AA06

ATC

mycophenolic acid; systemic

166.0

13.9

127

Kela drug reimbursment

Transplant complication

55.4

12.3

A05AA02

ATC

ursodeoxycholic acid; oral

41.5

11.7

Z94.4

ICD-10 Finland

Liver transplant status

112.3

9.6

L04AD01

ATC

ciclosporin; systemic

25.0

8.3

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

11.2

8.2

K83.0

ICD-10 Finland

Cholangitis

87.6

7.5

JJC00

NOMESCO Finland

Allogenic transplantation of liver

+∞

7.4

L04AD02

ATC

tacrolimus; systemic (calcineurin inhibitors)

33.2

7.3

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

5.8

7.3

H02AB04

ATC

methylprednisolone; systemic

4.7

6.9

TK800

NOMESCO Finland

Hemodialysis

18.7

6.9

Z94.0

ICD-10 Finland

Kidney transplant status

43.8

6.9

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

5.1

6.5

B25.8

ICD-10 Finland

Other cytomegaloviral diseases

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007080) Epstein Barr virus nuclear IgG Ab [Units/volume] in Serum

21.43

28.12

1.0

1.1

476.5

142.8

u/ml

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

17.56

27.35

1.3

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

19.98

27.18

1.0

1.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

12.55

21.51

1.3

1.4

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

17.32

18.06

1.1

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

16.04

16.30

1.1

—

(3034770) Mitochondria Ab [Titer] in Serum

11.57

12.54

1.8

1.4

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

5.83

11.51

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

100

4.34

9.59

2.3

1.6

—

(3012544) pH of Venous blood

4.92

8.64

6.4

2.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

7.38

8.30

1.5

1.3

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

4.81

8.13

6.5

2.6

6.0

5.8

kpa

0.33

(3006315) Basophils [#/volume] in Blood

396

3.79

7.93

12.7

6.1

0.0

e9/l

0.42

355

(3001604) Monocytes [#/volume] in Blood

396

3.79

7.93

12.3

6.0

0.6

e9/l

0.83

352

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

15.05

7.62

1.1

—

(3023368) Bacteria identified in Blood by Culture

178

3.31

7.30

5.8

4.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

253

3.22

7.25

6.2

2.9

—

(3022096) Basophils/100 leukocytes in Blood

363

3.39

7.23

13.1

6.2

0.7

0.31

338

(42870588) Differential panel, method unspecified - Blood

257

3.15

6.99

13.2

5.8

—

(3030467) Casts [#/volume] in Urine by Automated count

198

3.16

6.86

5.1

2.7

0.1

0.4

e6/l

1.29

145

(3006504) Eosinophils/100 leukocytes in Blood

372

3.26

6.76

13.7

6.1

2.4

2.8

0.95

349

(3019069) Monocytes/100 leukocytes in Blood

373

3.24

6.71

14.5

6.5

8.5

8.4

0.10

350

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

126

3.33

6.59

1.8

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

109

3.40

6.41

5.9

2.7

2.8

3.3

e6/l

0.10

(3018095) Leukocytes [#/volume] in Urine

259

2.99

6.38

6.7

3.5

39.8

29.9

e6/l

0.16

186

(3018010) Neutrophils/100 leukocytes in Blood

380

3.14

6.37

13.3

5.9

55.9

56.3

0.09

358

(3002582) Erythrocytes [#/volume] in Urine

224

2.94

6.11

5.3

2.9

15.9

330.2

e6/l

0.56

173

(36304419) Bacteria [Presence] in Urine

204

2.91

5.93

3.6

2.6

—

(40758558) Short blood count panel - Blood

207

2.86

5.74

12.1

7.6

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

14.03

5.71

1.1

1.0

—

(3000850) Epithelial cells [#/volume] in Urine

150

2.98

5.68

2.4

4.3

4.5

e6/l

0.05

134

(46235355) HIV 1 and 2 tests - Meaningful Use set

150

2.98

5.68

2.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

118

3.11

5.56

5.7

2.5

0.4

1.0

e6/l

1.41

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

345

2.78

5.43

12.7

6.5

1.2

mmol/l

0.86

290

(3018418) pH of Serum or Plasma

208

2.72

5.21

9.6

3.8

7.4

—

(3032080) INR in Blood by Coagulation assay

270

2.59

4.88

13.6

6.5

1.0

1.2

inr

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.15

4.73

2.0

1.7

—

(3024354) Oxygen [Partial pressure] in Venous blood

3.87

4.69

4.0

2.5

5.3

4.8

kpa

0.34

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

5.21

4.65

2.5

2.0

95.0

91.6

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

10.78

4.61

1.0

1.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

4.03

4.38

1.6

1.2

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

9.58

4.37

2.0

2.6

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

12.46

4.35

1.4

1.5

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

7.52

4.27

1.8

2.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

121

2.73

4.25

2.0

1.9

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.85

4.12

5.4

2.0

24.3

21.3

0.46

(3021589) Normoblasts [#/volume] in Blood

351

2.37

4.01

15.2

9.4

0.0

e9/l

0.71

286

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.91

3.86

1.8

1.6

—

(3017181) Myelocytes/100 leukocytes in Blood

3.04

3.83

9.1

4.2

0.6

—

(3021440) Promyelocytes/100 leukocytes in Blood

3.07

3.73

8.7

4.4

0.0

0.1

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

8.29

3.62

1.4

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.67

3.61

2.1

1.8

—

(3037522) Nuclear Ab [Titer] in Serum

117

2.55

3.57

2.1

1.4

888.9

373.3

titre

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.25

3.47

1.6

1.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

514

2.42

3.46

8.1

4.2

—

(4035726)

2.86

3.46

1.2

1.4

—

(3000991) Gas panel - Venous blood

3.18

3.36

12.4

4.7

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

3.06

3.34

2.6

2.2

55.6

77.7

ml/min/173m2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

173

2.29

3.32

2.5

2.1

—

(3045424) Erythrocytes [Presence] in Urine

9.05

3.31

2.0

1.3

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

9.05

3.31

3.2

1.6

0.9

g/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

374

2.13

3.18

10.1

4.8

0.0

estimate

0.00

(3044640) Blood type and Crossmatch panel - Blood

234

2.14

3.10

2.6

2.2

—

(3009261) Glucose [Presence] in Urine by Test strip

379

2.09

3.01

7.3

3.6

0.0

estimate

0.00

(3045414) Leukocytes [Presence] in Urine

3.61

3.00

1.6

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

197

2.14

2.93

10.4

4.6

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.78

2.87

13.6

2.8

107.3

66.5

ng/l

0.82

(3037756) Immunofixation for Serum or Plasma

4.75

2.86

1.3

1.4

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

3.27

2.61

1.1

1.5

—

(3026008) Bacteria identified in Urine by Culture

213

2.02

2.61

3.5

2.6

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

346

1.95

2.57

4.4

2.4

111.6

96.4

ug/l

0.30

319

(3016879) Cocaine [Presence] in Urine

3.06

2.57

1.1

1.3

—

(3022313) Gas panel - Capillary blood

3.17

2.49

2.3

4.1

—

(3000764) Benzodiazepines [Presence] in Urine

2.91

2.37

1.1

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

373

1.88

2.33

7.5

3.5

0.0

estimate

0.00

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.70

2.33

1.3

1.4

—

(3015736) pH of Urine

291

1.88

2.30

6.8

3.3

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

4.11

2.30

1.3

1.8

—

(3028300) Cannabinoids [Presence] in Urine

2.83

2.27

1.1

1.3

—

(3027944) Amphetamines [Presence] in Urine

2.83

2.27

1.1

1.3

—

(3027008) Opiates [Presence] in Urine

2.83

2.27

1.1

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.28

2.17

2.8

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.33

2.17

2.3

3.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

187

1.89

2.03

1.6

1.4

2.4

2.6

g/l

0.23

116

(3025941) Bacteria identified in Stool by Culture

2.64

2.01

1.7

1.3

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

4.73

1.96

1.0

1.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

804

3.01

1.95

29.8

12.8

19.8

21.8

mg/l

0.28

609

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

3.35

1.92

1.7

2.3

0.0

g/l

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

3.35

1.92

1.7

2.3

0.0

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.03

1.91

1.7

2.1

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.22

1.87

2.1

1.9

361.6

387.4

nmol/l

0.17

(3011397) Hemoglobin [Presence] in Urine by Test strip

161

1.85

1.77

6.3

3.6

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

3.07

1.76

1.7

2.2

0.0

0.6

g/l

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

3.07

1.76

1.7

2.3

0.0

g/l

—

(3052851) Hemolysis interference index of Serum or Plasma

3.30

1.69

3.2

3.5

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.94

1.68

1.6

2.0

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.10

1.65

3.2

2.3

34.5

28.9

u/l

0.43

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.64

1.64

4.0

1.3

0.2

g/l

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

2.64

1.64

2.5

4.3

23.3

25.4

mmol/l

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.82

1.61

3.0

2.8

25.9

25.4

mmol/l

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.82

1.61

1.3

1.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

364

1.65

1.58

3.7

3.8

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.55

1.58

4.0

1.3

1.1

1.2

g/l

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.55

1.58

4.1

1.6

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

171

1.72

1.44

2.4

1.9

2.8

mg/l

0.02

151

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

561

1.68

1.43

3.7

3.2

—

(4034850)

3.05

1.37

28.2

14.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.93

1.36

1.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.21

1.34

3.0

1.3

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

2.13

1.33

5.5

4.7

1.2

mmol/l

0.20

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

167

1.68

1.30

2.0

1.8

1.2

0.8

mg/l

0.28

135

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

142

1.72

1.29

1.6

1.5

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.49

1.26

1.3

2.6

0.7

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.39

1.20

1.3

2.6

0.8

1.0

—

(3029937) Albumin [Presence] in Urine by Test strip

191

1.58

1.12

6.8

4.1

0.0

estimate

0.00

(3014007) Fractional oxyhemoglobin in Arterial blood

2.28

1.10

8.7

7.3

94.3

95.3

—

(3019225) pH of Specimen

1.91

1.10

5.1

5.7

—

(3000492) Spirometry study

1.82

1.05

1.4

1.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.97

1.04

3.3

1.6

—

(3002256) Pathology report gross observation

101

1.70

1.01

1.6

1.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

178

1.55

1.00

1.5

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.67

0.87

1.5

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.49

0.83

1.6

1.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.24

0.77

1.6

1.5

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.24

0.77

3.0

1.2

—

(1761868) Lipid panel - Serum or Plasma

321

0.70

0.76

3.6

2.6

—

(40761535) Cells panel - Urine sediment

1.67

0.75

6.7

3.6

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.05

0.74

4.2

3.3

64.6

55.3

—

(3011288) Drugs identified in Urine by Screen method

2.05

0.74

2.0

1.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.05

0.74

1.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

292

1.38

0.73

1.7

2.0

111.4

98.2

pmol/l

0.71

144

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

292

1.38

0.73

7.6

3.6

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.97

0.72

2.4

1.3

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.97

0.72

2.4

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.97

0.72

2.4

1.3

—

(3003694) ABO and Rh group [Type] in Blood

229

1.39

0.68

1.5

1.4

—

(3019060) Gas panel - Arterial blood

1.68

0.68

2.4

4.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

220

1.39

0.68

2.0

1.7

1.3

1.4

mmol/l

0.23

188

(3019309) Folate [Moles/volume] in Red Blood Cells

131

1.46

0.65

1.6

1526.2

1195.1

nmol/l

0.44

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.76

0.64

10.6

6.0

—

(3013512) EKG study

214

1.37

0.62

4.2

3.7

—

(3042936) Bacteria identified in Isolate by Culture

115

1.47

0.61

2.8

2.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.61

0.0

1.7

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.61

0.0

2.2

—

17.9

—

(3022621) pH of Urine by Test strip

1.56

0.60

1.8

2.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

225

1.35

0.59

7.6

3.2

—

(4094501)

0.00

0.59

0.0

1.0

—

(3000330) Specific gravity of Urine by Test strip

1.71

0.58

13.3

2.4

—

(36660697) Celiac disease serology panel - Serum

1.58

0.57

1.3

1.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

750

1.45

0.57

23.9

12.0

79.0

85.8

ml/min/173m2

1.37

601

(40761536) Microorganisms panel - Urine sediment

1.53

0.56

6.7

3.7

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.44

0.43

1.6

1.2

—

28.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.59

0.43

2.0

2.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

727

1.33

0.43

4.9

5.0

37.1

39.3

mmol/mol

2.47

690

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.46

0.36

4.5

1.8

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.66

0.35

1.8

1.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

100

0.68

0.32

1.7

1.8

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.40

0.32

1.0

1.3

122.6

611.4

u/ml

—

(3000494) Fungus identified in Specimen by Culture

1.32

0.30

1.9

1.4

—

(4010399)

1.34

0.29

1.4

—

(3012516) Albumin [Mass/volume] in Urine

181

1.21

0.25

5.2

3.1

132.0

44.7

mg/l

—

110

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.37

0.24

1.2

1.4

—

(40761511) CBC panel - Blood by Automated count

847

1.36

0.23

20.9

11.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

192

1.19

0.23

7.5

4.0

16.8

7.2

mg/mmol

0.64

111

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

5.0

—

107.4

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

5.3

—

(43055225) Phosphorylated tau 181 [Mass/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.21

0.0

1.0

—

35.2

—

(3000242) Tau protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

262.8

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

482.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

111

0.79

0.21

1.8

2.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

1.1

—

(40768797) Stomach Pathology biopsy report

1.24

0.21

1.5

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

609

0.88

0.20

4.0

4.2

14.7

pmol/l

0.03

554

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.20

0.0

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.21

0.20

4.7

2.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.19

0.20

2.8

1.7

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

140

0.84

0.16

5.4

3.8

27.2

22.3

—

(3022145) Colonoscopy Study observation

1.14

0.15

2.6

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

163

1.13

0.12

1.4

1.3

22.1

30.9

iu/ml

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

727

0.90

0.10

4.5

4.8

1.7

1.8

mu/l

0.81

664

(3017732) Neutrophils [#/volume] in Blood

0.78

0.08

1.4

3.5

4.5

4.1

e9/l

—

(40768804) Tissue Pathology biopsy report

346

0.93

0.08

2.2

1.9

—

(3044889) 12 lead EKG panel

533

0.95

0.05

3.3

3.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

189

1.07

0.05

1.5

1.2

0.6

0.7

u/ml

—

(3009542) Hematocrit [Volume Fraction] of Blood

762

1.06

0.02

28.3

13.0

38.2

40.6

1.59

594

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

276

0.97

0.00

4.1

3.5

36.9

27.6

ng/l

0.16

170

(21494755) Public health laboratory ask at order entry panel

103

0.97

0.00

1.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.3

—

(3016038) Potassium [Moles/volume] in Urine

0.00

0.0

1.0

—

30.4

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.90

0.00

2.5

4.4

5.0

58.7

ug/l

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.8

—

(3037826) lamoTRIgine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

14.5

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.4

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.5

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

0.3

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

21.3

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.98

0.00

24.9

6.8

—

(4024509)

0.00

0.0

1.0

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.2

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

7.3

—

0.6

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

13.0

—

741.3

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

14.2

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

23.9

—

1376.4

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

7.9

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

2.5

—

125.2

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.6

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

1.8

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint CMV_HEPATITIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CMV_HEPATITIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: CMV_HEPATITIS – Cytomegaloviral hepatitis

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Cytomegaloviral hepatitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints