keratosis: A skin disorder consisting of hypertrophy of the stratum corneum of the skin.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
92 |
4. Check minimum number of eventsNone |
92 |
5. Include endpointsNone |
92 |
6. Filter based on genotype QC (FinnGen only) |
89 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E87
- Name in latin
- Alkalosis
Similar endpoints
↥List of similar endpoints to
Alkalosis
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 798 | 411 | 378 |
| Only index persons | 681 | 363 | 318 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 61.60 | 64.07 | 58.89 |
| Only index persons | 61.83 | 64.41 | 58.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 89 | 46 | 43 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 57.98 | 54.56 | 61.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 92
- Matched controls
- 920
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E87.3
ICD-10 Finland
Alkalosis
+∞
126.9
90
*
E87.6
ICD-10 Finland
Hypokalaemia
313.1
50.5
47
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
87.5
28.0
30
5
JN3AD
NOMESCO Finland
Abdominal CT examination
10.6
22.7
30
40
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
6.9
16.2
32
66
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
8.2
15.4
24
38
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.0
15.3
29
57
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.3
14.5
48
156
R11
ICD-10 Finland
Nausea and vomiting
7.3
13.5
23
40
A10AE04
ATC
insulin glargine; parenteral
7.3
13.0
22
38
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.7
12.2
57
236
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.6
11.8
42
141
AA1AD
NOMESCO Finland
CT of head and brain
4.6
11.2
38
122
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.3
10.9
49
194
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
4.1
10.3
45
173
WX882
NOMESCO Finland
High dependency care
45.4
10.2
12
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
29.9
10.1
13
5
C03CA01
ATC
furosemide; systemic
4.1
9.9
41
151
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.3
9.6
33
106
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
+∞
9.5
9
*
WX892
NOMESCO Finland
Monitored bed care
9.7
9.4
19
24
N05AH04
ATC
quetiapine; oral
4.4
9.0
28
83
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.6
8.8
19
41
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.3
8.6
20
46
TPH04
NOMESCO Finland
Cathetrisation of vein
4.2
8.6
30
96
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.6
8.5
18
38
H04AA01
ATC
glucagon; nasal, parenteral
+∞
8.5
8
*
C03DA01
ATC
spironolactone; oral
5.2
8.4
20
47
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
4.9
8.3
21
52
103
Kela drug reimbursment
Diabetes, insulin-treated
3.8
8.3
35
128
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
4.4
8.1
24
68
A46
ICD-10 Finland
Erysipelas
4.9
8.0
20
49
K92.0
ICD-10 Finland
Haematemesis
13.5
7.9
13
11
A10AB05
ATC
insulin aspart; parenteral
7.4
7.7
18
29
JN4AD
NOMESCO Finland
Body CT examination
5.1
7.6
18
42
N17.8
ICD-10 Finland
Other acute renal failure
86.8
7.5
8
*
TPH07
NOMESCO Finland
Cathetrisation of artery
6.6
7.4
19
35
C08CA01
ATC
amlodipine; oral
3.3
7.4
45
206
E87.5
ICD-10 Finland
Hyperkalaemia
+∞
7.4
7
*
A10AE06
ATC
insulin degludec; parenteral
22.1
7.3
10
5
A11CC03
ATC
alfacalcidol; systemic
32.9
7.3
9
*
N05BA04
ATC
oxazepam; oral
3.4
7.1
34
134
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.5
6.9
19
50
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
18.5
6.9
10
6
E86
ICD-10 Finland
Volume depletion
43.4
6.9
8
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
43.4
6.9
8
*
N05CF01
ATC
zopiclone; oral
3.2
6.8
40
178
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
11.3
6.8
12
12
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.7
6.7
17
42
N05CF02
ATC
zolpidem; oral
3.7
6.6
25
84
F10.24
ICD-10 Finland
Alcohol depence active use
15.8
6.6
10
7
K22.6
ICD-10 Finland
Gastro-oesophageal laceration-haemorrhage syndrome
74.8
6.5
7
*
E83.51
ICD-10 Finland
Hypocalcemia
74.8
6.5
7
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.8
6.4
23
74
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.1
6.4
41
190
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
28.9
6.3
8
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
28.9
6.3
8
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
+∞
6.3
6
*
A02BC02
ATC
pantoprazole; systemic
3.6
6.3
72
463
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
11.2
6.2
11
11
ZXA00
NOMESCO Finland
Right side
3.2
6.1
33
138
R53
ICD-10 Finland
Malaise and fatigue
3.2
6.1
33
138
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
16.4
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
54
93
12.64
34.88
7.9
3.7
0.81
0.82
mmol/l
0.19
54
87
43
63
11.94
31.07
16.1
5.3
98.56
104.81
mmol/l
4.19
43
63
48
147
5.74
15.82
3.5
1.9
3.07
3.22
mg/l
0.17
43
125
69
296
6.32
15.05
22.8
5.5
1.18
1.22
mmol/l
2.68
62
252
40
114
5.44
14.08
2.1
1.7
1321.01
1223.78
nmol/l
0.26
33
83
36
100
5.27
12.92
2.2
1.9
—
—
—
0
0
62
272
4.92
12.35
16.7
12.9
1.12
1.29
inr
1.03
18
83
21
23
11.47
11.26
13.0
2.7
28.48
23.69
mmol/l
2.01
21
23
53
219
4.35
11.13
7.5
3.5
48.73
49.41
ng/l
0.01
40
147
58
260
4.33
10.78
4.7
2.0
71.60
75.21
nmol/l
0.39
53
228
22
29
9.61
10.70
17.0
6.5
93.94
93.67
%
0.05
22
29
22
29
9.61
10.70
17.0
6.4
0.76
0.64
%
0.67
22
29
22
30
9.28
10.49
17.0
5.4
1.60
1.65
%
0.05
22
30
20
41
5.96
9.84
2.3
1.7
—
—
—
0
0
53
238
3.89
9.50
6.1
2.8
—
—
—
0
0
56
261
3.93
9.50
2.8
1.9
92.38
99.74
pmol/l
0.46
37
135
26
70
4.78
9.41
1.9
1.7
—
—
—
0
0
26
71
4.71
9.24
1.9
1.8
—
—
—
0
0
21
33
7.92
9.17
9.7
1.5
121.00
125.73
g/l
0.32
21
33
18
22
9.88
9.10
16.0
6.6
27.85
23.74
mmol/l
1.71
18
22
33
110
4.12
9.03
4.6
3.3
2.47
2.46
mmol/l
0.15
28
91
68
381
4.01
8.37
18.2
10.1
4.85
3.88
e9/l
2.50
63
332
36
134
3.77
8.34
5.4
2.3
—
—
—
0
0
35
129
3.77
8.21
2.8
1.5
1.23
0.90
mg/l
0.48
29
93
18
29
7.44
7.72
14.3
1.7
27.34
25.01
mmol/l
0.49
18
29
17
29
6.94
7.03
13.2
1.6
44.52
49.67
%
0.28
17
29
41
182
3.26
7.02
6.4
3.5
63.29
8.47
mg/mmol
1.06
29
112
18
34
6.32
6.92
1.7
1.4
—
—
—
0
0
17
42
4.74
6.69
2.4
1.7
49.00
71.47
ml/min/173m2
—
7
15
11
10
12.29
6.49
1.2
1.1
—
—
—
0
0
16
29
6.45
6.35
1.6
1.6
—
—
—
0
0
12
15
9.01
6.05
14.6
3.1
30.74
24.70
mmol/l
1.45
12
15
16
31
6.02
6.05
12.0
1.4
1.34
1.15
%
0.28
16
31
16
31
6.02
6.05
12.0
1.4
0.66
0.64
%
0.06
16
31
12
19
7.09
5.28
9.3
3.8
1.54
1.16
mmol/l
0.45
12
19
29
124
2.95
5.07
2.5
1.8
682.50
463.61
pmol/l
0.57
22
103
9
10
9.82
4.90
1.7
1.9
—
—
—
0
0
7
5
14.98
4.65
1.1
1.0
—
—
—
0
0
10
16
6.87
4.43
11.0
4.4
3.65
3.97
mmol/l
—
10
16
49
290
2.48
4.38
4.9
2.5
—
—
—
0
0
26
114
2.79
4.28
3.3
2.6
2.65
0.69
e6/l
0.41
13
67
31
158
2.45
3.73
4.7
2.5
389.26
4973.51
umol/l
0.74
31
136
51
327
2.26
3.58
4.7
2.9
0.00
0.00
estimate
-0.00
12
67
51
328
2.25
3.54
5.7
3.8
0.00
0.00
estimate
-0.00
13
62
51
331
2.21
3.43
4.7
2.9
0.00
0.00
estimate
—
10
61
23
107
2.53
3.32
3.5
2.7
8.51
1.82
e6/l
—
10
60
8
15
5.73
3.27
1.9
1.7
—
—
—
0
0
8
17
5.04
2.99
1.0
1.3
—
—
—
0
0
9
22
4.42
2.97
1.1
1.4
—
16.03
—
0
6
9
23
4.22
2.86
3.2
2.5
—
—
—
0
0
7
14
5.31
2.78
1.0
1.8
—
—
—
0
0
83
709
2.74
2.65
50.4
12.3
26.34
20.86
mg/l
0.99
76
531
8
20
4.28
2.63
3.5
2.3
—
—
—
0
0
6
11
5.75
2.58
1.0
1.8
—
—
—
0
0
24
128
2.18
2.52
1.8
1.1
0.86
0.70
u/ml
—
10
27
30
175
2.06
2.51
6.3
3.3
0.00
0.00
estimate
—
10
62
8
22
3.88
2.42
1.9
2.4
11.60
9.82
g/l
—
8
22
5
8
6.53
2.40
1.0
1.3
—
—
—
0
0
5
8
6.53
2.40
1.6
2.1
—
—
—
0
0
5
8
6.53
2.40
1.6
2.1
—
—
—
0
0
5
8
6.53
2.40
1.6
2.1
—
—
—
0
0
8
23
3.71
2.33
1.9
2.4
7.06
7.55
g/l
—
8
23
8
23
3.71
2.33
1.9
2.4
—
—
—
0
0
5
9
5.80
2.24
1.0
1.3
—
—
—
0
0
6
14
4.50
2.19
5.2
3.9
67.33
54.07
%
—
6
14
83
727
2.45
2.05
67.6
13.2
137.95
139.93
mmol/l
6.19
83
703
7
21
3.52
2.01
6.7
2.4
60.71
116.31
u/ml
—
7
16
8
27
3.14
1.99
2.3
1.9
—
—
—
0
0
5
11
4.74
1.96
5.8
2.6
233.60
166.00
%
—
5
11
7
22
3.36
1.92
1.9
2.5
3.04
3.00
g/l
—
7
22
83
732
2.37
1.90
67.0
13.2
3.86
3.96
mmol/l
2.65
83
708
6
17
3.70
1.87
2.8
2.3
—
—
—
0
0
7
23
3.21
1.84
2.0
2.4
3.89
3.63
g/l
—
7
23
14
68
2.25
1.81
4.1
3.4
—
—
—
0
0
5
13
4.00
1.74
6.0
1.6
88.40
88.08
%
—
5
13
5
13
4.00
1.74
2.0
1.3
—
—
—
0
0
6
19
3.30
1.69
2.0
2.6
0.00
0.00
g/l
—
6
19
6
19
3.30
1.69
2.0
2.6
0.00
0.00
g/l
—
6
19
6
19
3.30
1.69
1.5
1.1
—
—
—
0
0
6
19
3.30
1.69
2.0
2.6
39.65
38.20
g/l
—
6
19
6
20
3.13
1.61
2.0
2.7
0.00
0.00
g/l
—
6
20
5
15
3.46
1.54
1.0
1.3
—
—
—
0
0
5
15
3.46
1.54
1.8
1.7
—
—
—
0
0
5
15
3.46
1.54
1.8
1.7
—
—
—
0
0
6
21
2.98
1.53
3.7
1.3
—
—
—
0
0
5
16
3.24
1.45
1.0
1.1
—
—
—
0
0
36
259
1.64
1.44
5.7
2.9
—
—
—
0
0
6
133
0.41
1.42
1.5
1.3
—
—
—
0
0
77
674
1.87
1.40
44.8
11.8
77.87
83.74
ml/min/173m2
1.08
71
548
5
17
3.05
1.37
1.4
1.5
—
—
—
0
0
8
36
2.34
1.28
1.6
1.4
—
—
—
0
0
5
19
2.72
1.23
2.0
1.2
—
—
—
0
0
5
19
2.72
1.23
2.0
1.2
—
—
—
0
0
83
761
1.93
1.11
58.5
13.8
99.23
75.34
umol/l
1.73
83
761
17
113
1.62
0.90
1.2
1.3
55.97
35.92
iu/ml
—
7
42
0
27
0.00
0.79
0.0
1.3
—
253.72
—
0
11
5
24
2.14
0.76
1.2
2.2
—
—
—
0
0
76
703
1.47
0.65
5.3
3.9
4.33
4.72
mmol/l
2.62
69
650
0
22
0.00
0.60
0.0
1.8
—
—
—
0
0
75
700
1.39
0.53
5.3
3.9
1.48
1.48
mmol/l
0.00
69
643
9
65
1.43
0.52
1.9
2.0
—
—
—
0
0
51
454
1.28
0.50
2.9
3.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
72
679
1.28
0.38
5.2
3.5
1.25
1.29
mmol/l
0.26
66
622
9
74
1.24
0.26
1.9
2.2
—
—
—
0
0
22
192
1.19
0.23
5.7
4.3
20.26
21.69
%
—
7
83
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
13
110
1.21
0.18
1.2
1.2
1.87
13.52
u/ml
—
6
34
83
811
1.24
0.14
68.1
17.5
125.28
136.83
g/l
7.61
83
794
9
83
1.09
0.07
20.0
5.8
—
—
—
0
0
14
128
1.11
0.07
1.5
1.6
—
—
—
0
0
71
701
1.06
0.03
6.2
4.1
6.51
5.89
mmol/l
1.53
64
642
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
29.05
—
0
6
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_ALKALOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ALKALOSIS | 3.225 [1.93, 5.39] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 300 females with E4_ALKALOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ALKALOSIS | 4.629 [2.28, 9.39] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 246 males with E4_ALKALOSIS died.
Mortality risk
Mortality risk for people of age
years, who have E4_ALKALOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.279% | 1.062% |
| 5 | 1.763% | 5.621% |
| 10 | 4.404% | 13.68% |
| 15 | 8.305% | 24.568% |
| 20 | 13.736% | 38.647% |
Relationships between endpoints
↥Index endpoint: E4_ALKALOSIS – Alkalosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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