keratosis: A skin disorder consisting of hypertrophy of the stratum corneum of the skin.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
81 |
4. Check minimum number of eventsNone |
81 |
5. Include endpointsNone |
81 |
6. Filter based on genotype QC (FinnGen only) |
81 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E87
- Name in latin
- Alkalosis
Similar endpoints
↥List of similar endpoints to
Alkalosis
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 798 | 411 | 378 |
| Only index persons | 681 | 363 | 318 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 61.60 | 64.07 | 58.89 |
| Only index persons | 61.83 | 64.41 | 58.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 81 | 40 | 41 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 58.04 | 54.15 | 61.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 72
- Matched controls
- 718
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E87.3
ICD-10 Finland
Alkalosis
+∞
98.1
70
*
E87.6
ICD-10 Finland
Hypokalaemia
353.2
39.0
36
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
96.9
19.9
21
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
22.5
14.0
20
12
K92.0
ICD-10 Finland
Haematemesis
47.2
10.3
12
*
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
+∞
9.6
9
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.2
9.0
33
100
R11
ICD-10 Finland
Nausea and vomiting
10.7
8.9
17
20
F10.24
ICD-10 Finland
Alcohol depence active use
101.4
8.6
9
*
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
+∞
7.4
7
*
JN3AD
NOMESCO Finland
Abdominal CT examination
9.2
7.4
15
20
WX892
NOMESCO Finland
Monitored bed care
9.9
7.2
14
17
AA1AD
NOMESCO Finland
CT of head and brain
4.8
7.2
26
75
N17.9
ICD-10 Finland
Acute renal failure, unspecified
19.0
7.0
10
6
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
19.0
7.0
10
6
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.0
6.8
34
132
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.1
6.8
33
124
N07BB01
ATC
disulfiram; oral
12.7
6.6
11
10
E86
ICD-10 Finland
Volume depletion
76.3
6.5
7
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
+∞
6.3
6
*
SPAT1265
SPAT
Breathalyser
+∞
6.3
6
*
WX882
NOMESCO Finland
High dependency care
14.2
6.3
10
8
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.8
6.1
21
57
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.6
6.1
22
63
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3012095) Magnesium [Moles/volume] in Serum or Plasma
48
82
12.91
31.30
8.0
4.0
mmol/l
0.8
0.8
0.13
48
76
(3012544) pH of Venous blood
33
40
13.23
27.37
15.6
3.8
—
—
—
0
0
(3000991) Gas panel - Venous blood
29
35
12.35
23.87
23.2
6.9
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
48
140
6.96
17.42
13.9
4.7
—
—
—
0
0
(3022313) Gas panel - Capillary blood
17
18
11.69
14.87
11.6
2.7
—
—
—
0
0
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
43
129
5.97
14.67
3.4
2.0
mg/l
3.1
3.3
0.22
38
110
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
19
25
9.62
14.20
16.2
6.3
%
0.8
0.6
0.62
19
25
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
19
26
9.24
13.76
16.1
5.2
%
1.6
1.7
0.04
19
26
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
60
258
6.11
13.00
22.2
5.7
mmol/l
1.2
1.2
1.97
53
219
(3014007) Fractional oxyhemoglobin in Arterial blood
18
25
8.97
12.83
16.9
6.4
%
93.5
93.1
0.07
18
25
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
17
22
9.51
12.80
11.1
2.8
mmol/l
29.1
23.5
1.94
17
22
(3019309) Folate [Moles/volume] in Red Blood Cells
36
106
5.31
12.20
2.2
1.8
nmol/l
1303.4
1280.7
0.05
29
80
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
12
11
12.63
11.33
1.1
1.0
—
—
—
0
0
(3004119) Hemoglobin [Mass/volume] in Venous blood
17
26
8.01
11.12
11.4
1.6
g/l
118.8
125.8
0.41
17
26
(3018418) pH of Serum or Plasma
43
158
4.67
10.84
12.0
4.3
ph
7.4
7.4
—
9
36
(3009445) Proteinase 3 Ab [Units/volume] in Serum
15
21
8.54
10.52
1.1
1.0
—
—
—
0
0
(3019060) Gas panel - Arterial blood
16
27
7.14
9.53
9.1
4.1
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
17
31
6.67
9.43
1.8
1.3
—
—
—
0
0
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
42
168
4.12
9.12
3.4
1.8
u/l
202.4
169.9
0.23
42
154
(3004490) Bicarbonate [Moles/volume] standard in Capillary blood
12
15
9.22
9.11
14.6
3.1
mmol/l
30.7
24.7
1.45
12
15
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
30
94
4.48
9.07
1.9
1.8
—
—
—
0
0
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
31
101
4.35
8.89
4.6
3.5
mmol/l
2.5
2.5
0.09
26
83
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
47
209
3.98
8.66
7.5
3.6
ng/l
52.6
50.6
0.04
35
146
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
14
23
7.15
8.49
13.0
1.5
%
1.4
1.2
0.19
14
23
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
49
228
3.91
8.36
4.7
2.0
nmol/l
70.6
76.1
0.73
44
196
(3037522) Nuclear Ab [Titer] in Serum
25
72
4.58
8.35
1.4
1.4
titre
297.1
783.2
—
7
19
(3024928) Oxygen saturation in Venous blood
11
5
25.06
8.26
2.6
2.0
—
—
—
0
0
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
14
24
6.84
8.16
15.0
1.7
%
47.5
44.5
0.14
14
24
(3027273) Bicarbonate [Moles/volume] in Venous blood
14
25
6.56
7.85
14.8
1.8
mmol/l
26.8
25.4
0.21
14
25
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
17
38
5.40
7.59
2.6
1.7
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
32
118
3.83
7.58
5.4
2.3
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
31
112
3.86
7.56
3.0
1.6
mg/l
1.2
0.9
0.41
25
82
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
46
216
3.61
7.53
6.1
2.7
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
14
27
6.06
7.26
1.7
1.6
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
22
65
4.27
7.02
1.7
1.6
—
—
—
0
0
(40761535) Cells panel - Urine sediment
15
32
5.53
7.01
6.9
3.1
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
47
232
3.44
6.96
3.0
1.9
pmol/l
89.9
97.8
0.65
31
117
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
22
66
4.20
6.87
1.7
1.7
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
44
211
3.38
6.79
14.2
9.7
inr
1.1
1.2
1.25
11
69
(3018405) Lactate [Moles/volume] in Arterial blood
10
15
7.46
6.47
10.1
3.1
mmol/l
1.6
1.2
—
10
15
(40758558) Short blood count panel - Blood
34
147
3.26
6.10
12.9
6.0
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
20
61
4.03
6.06
2.0
1.4
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
36
164
3.15
5.88
6.9
2.2
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
30
124
3.25
5.75
3.8
2.5
e6/l
6.8
4.3
0.32
30
106
(3020682) Albumin/Creatinine [Ratio] in Urine
36
167
3.08
5.66
5.6
3.7
mg/mmol
26.7
8.1
0.83
26
99
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
68
455
4.08
5.63
25.3
7.6
u/l
93.9
76.4
1.03
68
415
(3012516) Albumin [Mass/volume] in Urine
34
154
3.08
5.56
4.6
3.1
mg/l
161.9
45.1
1.04
25
94
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
9
8
12.45
5.43
1.7
2.0
—
—
—
0
0
(3034770) Mitochondria Ab [Titer] in Serum
9
8
12.45
5.43
1.2
1.0
—
—
—
0
0
(3007733) Chloride [Moles/volume] in Urine
5
0
+∞
5.26
5.6
0.0
mmol/l
77.4
—
—
5
0
(3011648) Oxygen content in Venous blood
5
0
+∞
5.26
1.4
0.0
%
10.1
—
—
5
0
(3009508) Creatinine [Moles/volume] in Urine
35
166
2.95
5.22
4.8
2.9
mmol/l
6.9
8.2
0.98
28
129
(3035637) Corticotropin [Mass/volume] in Plasma
9
9
11.06
5.17
1.8
1.7
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
41
214
2.85
5.10
5.6
3.4
e6/l
17.2
84.1
0.75
34
150
(3042936) Bacteria identified in Isolate by Culture
23
87
3.30
5.02
4.3
1.5
—
—
—
0
0
(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)
13
33
4.50
4.93
1.8
1.9
ml/min/173m2
55.8
71.8
—
5
13
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
9
10
9.95
4.92
1.2
1.1
—
—
—
0
0
(3052851) Hemolysis interference index of Serum or Plasma
10
21
5.29
4.67
4.4
3.6
—
—
—
0
0
(3021901) Oxygen saturation in Capillary blood
8
8
10.92
4.63
3.5
2.5
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
37
191
2.73
4.60
15.3
6.3
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
14
40
4.02
4.57
2.1
2.1
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
28
126
2.87
4.50
4.5
2.8
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
34
172
2.68
4.35
3.1
2.4
—
—
—
0
0
(3000570) Elastase.pancreatic [Mass/mass] in Stool
9
13
7.63
4.29
1.6
1.5
ug/g
210.8
170.8
—
9
5
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
24
103
2.89
4.17
3.5
2.5
e6/l
2.6
0.7
0.41
13
61
(3037467) Urinalysis macro (dipstick) panel - Urine
61
417
2.87
4.17
6.4
3.8
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
33
171
2.57
3.96
4.5
2.8
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
43
255
2.46
3.85
6.3
4.4
—
—
—
0
0
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
25
122
2.52
3.33
2.6
1.8
pmol/l
684.8
467.3
0.47
19
102
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
21
97
2.57
3.11
3.6
2.6
e6/l
8.5
1.7
—
10
56
(3020891) Body temperature
9
21
4.68
3.10
28.7
3.1
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
9
22
4.46
2.98
17.2
8.4
—
—
—
0
0
(3015736) pH of Urine
37
224
2.20
2.97
4.7
2.8
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
16
66
2.77
2.93
2.1
1.6
—
—
—
0
0
(1616796) Gas panel - Central venous blood
6
9
7.09
2.92
7.8
2.9
—
—
—
0
0
(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis
8
18
4.81
2.87
1.9
2.7
g/l
11.6
10.0
—
8
18
(3028271) Lactate [Moles/volume] in Capillary blood
5
6
8.77
2.78
2.6
1.5
mmol/l
2.0
1.5
—
5
6
(3019230) Fractional oxyhemoglobin in Venous blood
5
6
8.77
2.78
2.4
1.8
%
74.8
64.9
—
5
6
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
8
19
4.55
2.76
1.9
2.7
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
44
293
2.10
2.70
4.7
3.1
estimate
0.0
0.0
—
9
60
(3028026) IgM [Mass/volume] in Serum or Plasma
12
44
3.03
2.68
2.2
1.6
g/l
1.2
1.1
0.27
12
36
(40768797) Stomach Pathology biopsy report
17
76
2.57
2.66
1.6
1.2
—
—
—
0
0
(3013512) EKG study
30
174
2.15
2.62
4.2
3.4
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
44
296
2.07
2.60
5.7
3.9
estimate
0.0
0.0
—
10
60
(3013290) Carbon dioxide [Partial pressure] in Blood
6
11
5.79
2.59
9.5
1.9
kpa
6.0
4.9
—
6
11
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
8
21
4.11
2.54
2.0
2.5
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
27
152
2.16
2.53
4.4
2.5
umol/l
385.8
5188.2
0.74
27
130
(3019225) pH of Specimen
13
52
2.79
2.50
11.5
4.0
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
44
299
2.03
2.50
4.7
3.1
estimate
0.0
0.0
—
7
59
(3012110) Lysozyme [Mass/volume] in Serum or Plasma
6
12
5.30
2.45
1.3
1.3
mg/l
12.2
12.2
—
6
12
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
73
622
2.76
2.34
49.9
12.7
mg/l
27.4
20.8
1.16
68
457
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
7
18
4.15
2.31
2.1
2.3
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
8
24
3.58
2.24
1.6
1.5
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
5
9
5.83
2.24
5.8
2.9
%
233.6
175.1
—
5
9
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
6
14
4.54
2.19
2.2
1.8
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
9
31
3.14
2.15
2.1
1.4
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
5
10
5.25
2.10
1.4
1.4
—
—
—
0
0
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
6
15
4.23
2.08
2.0
3.1
g/l
0.0
0.0
—
6
15
(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis
6
15
4.23
2.08
2.0
3.1
g/l
0.0
0.0
—
6
15
(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis
6
15
4.23
2.08
2.0
3.1
g/l
39.6
37.9
—
6
15
(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis
6
16
3.96
1.97
2.0
3.1
g/l
0.0
0.0
—
6
16
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
6
16
3.96
1.97
1.0
1.3
—
—
—
0
0
(3027315) Oxygen [Partial pressure] in Blood
5
11
4.76
1.97
10.6
1.9
kpa
9.1
7.7
—
5
11
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
5
11
4.76
1.97
6.0
1.7
%
88.4
86.3
—
5
11
(3029937) Albumin [Presence] in Urine by Test strip
26
158
1.95
1.94
6.2
3.6
estimate
0.0
0.0
—
8
61
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
20
111
2.06
1.90
1.7
1.2
u/ml
0.9
0.7
—
7
24
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
17
89
2.15
1.87
2.1
1.7
—
—
—
0
0
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
5
12
4.36
1.85
1.8
1.3
—
—
—
0
0
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
5
12
4.36
1.85
1.8
1.3
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
6
18
3.51
1.78
3.8
1.3
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
5
13
4.02
1.74
2.0
1.2
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
5
13
4.02
1.74
2.0
1.2
—
—
—
0
0
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
5
13
4.02
1.74
1.4
1.7
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
5
13
4.02
1.74
2.0
1.2
—
—
—
0
0
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
5
14
3.73
1.64
5.4
3.9
%
67.8
54.1
—
5
14
(44816559) Phosphatidylethanol [Mass/volume] in Blood
5
15
3.48
1.54
1.4
1.3
—
—
—
0
0
(3000492) Spirometry study
12
59
2.21
1.52
1.5
1.5
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
5
16
3.26
1.46
3.2
2.4
—
—
—
0
0
(3019550) Sodium [Moles/volume] in Serum or Plasma
72
642
2.09
1.39
68.9
13.8
mmol/l
138.1
139.9
4.76
72
620
(40760892) CBC W Ordered Manual Differential panel - Blood
21
132
1.80
1.38
6.0
6.3
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
5
17
3.06
1.38
1.4
1.1
—
—
—
0
0
(3037121) Protein [Mass/volume] in Urine
5
18
2.89
1.30
11.8
2.8
g/l
0.2
0.2
—
5
7
(3023103) Potassium [Moles/volume] in Serum or Plasma
72
646
2.03
1.26
68.3
13.8
mmol/l
3.9
4.0
2.17
72
624
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
6
26
2.41
1.21
2.7
1.6
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
5
20
2.59
1.17
1.2
1.4
—
—
—
0
0
(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma
5
21
2.47
1.10
7.6
2.4
u/ml
18.0
116.3
—
5
16
(3044889) 12 lead EKG panel
51
424
1.55
1.06
6.6
3.6
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
16
237
0.60
1.03
5.3
2.6
—
—
—
0
0
(4035726)
9
50
1.90
1.00
4.2
1.3
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
67
598
1.70
0.98
44.7
12.3
ml/min/173m2
78.3
82.8
0.63
61
482
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
5
101
0.46
0.97
1.6
1.3
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
31
235
1.52
0.97
5.6
3.1
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
11
64
1.83
0.91
1.9
1.5
—
—
—
0
0
(3022145) Colonoscopy Study observation
11
65
1.80
0.87
2.2
1.2
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
16
106
1.63
0.87
2.3
1.8
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
10
58
1.83
0.84
4.3
4.1
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
11
66
1.77
0.83
4.4
3.5
—
—
—
0
0
(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum
0
24
0.00
0.80
0.0
1.3
—
203.0
—
0
10
(3020564) Creatinine [Moles/volume] in Serum or Plasma
72
668
1.70
0.79
59.2
14.5
umol/l
93.9
76.8
1.48
72
668
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
15
102
1.58
0.74
1.3
1.3
iu/ml
56.0
27.7
—
7
39
(3048689) Calprotectin [Mass/mass] in Stool
10
63
1.67
0.65
6.0
2.2
ug/g
222.0
111.4
—
10
49
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
67
620
1.47
0.58
5.0
4.1
mmol/l
4.2
4.7
2.84
61
568
(3021879) Hepatitis B virus core Ab [Presence] in Serum
7
46
1.57
0.50
1.6
1.5
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
66
617
1.38
0.46
5.0
4.0
mmol/l
1.4
1.5
0.14
61
561
(3003694) ABO and Rh group [Type] in Blood
13
170
0.72
0.44
1.4
1.5
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
9
67
1.39
0.40
2.2
1.8
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
(3042111) Morphology [Interpretation] in Bone marrow Narrative
0
19
0.00
0.39
0.0
2.6
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
5
36
1.41
0.39
1.4
1.2
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
9
70
1.32
0.38
20.0
6.2
—
—
—
0
0
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
13
101
1.34
0.34
1.2
1.2
u/ml
1.9
11.7
—
6
30
(40761511) CBC panel - Blood by Automated count
70
669
1.34
0.33
46.3
11.2
—
—
—
0
0
(3003338) MCHC [Mass/volume]
56
524
1.22
0.30
64.7
15.9
g/l
330.5
333.0
1.03
56
519
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
63
600
1.23
0.26
5.0
3.6
mmol/l
1.3
1.3
0.28
58
545
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
42
388
1.17
0.24
2.9
3.2
—
—
—
0
0
(4010399)
5
37
1.37
0.24
2.0
1.3
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
5
42
1.20
0.22
1.0
1.2
—
—
—
0
0
(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
(21494434) Karyotype in Bone marrow
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
13
0.00
0.21
0.0
3.9
—
17.8
—
0
13
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
(3002256) Pathology report gross observation
9
82
1.11
0.15
1.6
1.3
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
26
240
1.12
0.13
4.5
2.0
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
16
178
0.87
0.13
5.1
2.9
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
6
57
1.06
0.09
2.3
1.9
—
—
—
0
0
(3000963) Hemoglobin [Mass/volume] in Blood
72
708
1.15
0.07
68.8
18.2
g/l
125.4
136.9
6.26
72
693
(3024731) MCV [Entitic volume]
72
707
1.17
0.07
68.2
18.1
fl
90.8
91.0
0.14
72
690
(3035941) MCH [Entitic mass]
72
707
1.17
0.07
68.2
18.1
pg
29.8
30.3
1.12
72
690
(3009542) Hematocrit [Volume Fraction] of Blood
58
569
1.07
0.05
53.7
12.8
%
38.2
40.1
1.41
37
408
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
20
191
1.06
0.03
6.2
4.3
%
20.3
21.9
—
7
83
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
10
106
0.94
0.01
1.4
1.6
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
61
616
0.96
0.00
6.3
4.3
mmol/l
6.4
5.9
1.12
55
561
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
6
65
0.92
0.00
2.3
2.1
—
—
—
0
0
(3005570) Glucose [Moles/volume] in Urine
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells
0
6
0.00
0.00
0.0
3.2
—
—
—
0
0
(1617658) Protocol used for examination of sentinel lymph nodes
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016914) Bacteria identified in Cerebral spinal fluid by Culture
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3000060) B lymphocytes [#/volume] in Blood
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3023419) Bacteria identified in Sputum by Culture
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3032773) Endomysium IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum
0
5
0.00
0.00
0.0
1.6
—
32.7
—
0
5
(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3019897) Erythrocyte distribution width [Ratio] by Automated count
0
7
0.00
0.00
0.0
1.0
—
13.0
—
0
7
(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(3000093) Morphology [Interpretation] in Blood Narrative
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3045424) Erythrocytes [Presence] in Urine
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3035933) Granulocytes/100 leukocytes in Blood
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells
0
6
0.00
0.00
0.0
3.2
—
—
—
0
0
(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline
0
5
0.00
0.00
0.0
1.2
—
6.4
—
0
5
(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(21491868) Cryoglobulin [Mass/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3042975) Streptococcus sp identified in Isolate by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_ALKALOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ALKALOSIS | 3.225 [1.93, 5.39] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 300 females with E4_ALKALOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ALKALOSIS | 4.629 [2.28, 9.39] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 246 males with E4_ALKALOSIS died.
Mortality risk
Mortality risk for people of age
years, who have E4_ALKALOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.279% | 1.062% |
| 5 | 1.763% | 5.621% |
| 10 | 4.404% | 13.68% |
| 15 | 8.305% | 24.568% |
| 20 | 13.736% | 38.647% |
Relationships between endpoints
↥Index endpoint: E4_ALKALOSIS – Alkalosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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