Risteys · E4

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E78.6 Hospital discharge: ICD-9 — 2725 Cause of death: ICD-10 — E78.6 Cause of death: ICD-9 — 2725 2 out of 7 registries used, show all original rules.	73
4. Check minimum number of events None	73
5. Include endpoints None	73
6. Filter based on genotype QC (FinnGen only)	73

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	675	279	394
Only index persons	614	256	358
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	65.75	68.29	63.94
Only index persons	65.71	68.17	63.94

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	73	23	50
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	60.76	60.01	61.11

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
66: Matched controls
658

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E78.63

ICD-10 Finland

Low HDL syndrome

+∞

45.0

E78.69

ICD-10 Finland

Lipoprotein deficiency, other or unspecified

+∞

11.8

E78.01

ICD-10 Finland

Pure hypercholesterolaemia

9.8

9.7

C07AB07

ATC

bisoprolol; oral

5.1

8.9

195

E78.6

ICD-10 Finland

Lipoprotein deficiency

+∞

8.5

E87.6

ICD-10 Finland

Hypokalaemia

+∞

8.5

C10AA05

ATC

atorvastatin; oral

4.8

8.5

160

E78.00

ICD-10 Finland

Familial hypercholesterolaemia

51.3

7.9

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

5.1

7.8

E87.1

ICD-10 Finland

Hypo-osmolality and hyponatraemia

89.8

7.6

E78.5

ICD-10 Finland

Hyperlipidaemia, unspecified

14.3

7.4

I10

ICD-10 Finland

Essential (primary) hypertension

4.4

7.0

286

T90

ICPC

Diabetes non-insulin dependent

4.5

6.6

E78.61

ICD-10 Finland

Abetalipoproteinaemia

+∞

6.3

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.7

6.1

194

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

255

3.80

6.89

8.1

5.9

mmol/l

1.2

0.05

220

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

7.02

6.64

2.2

1.8

ug/l

410.8

584.4

0.21

(3020682) Albumin/Creatinine [Ratio] in Urine

149

3.40

6.10

6.4

3.2

mg/mmol

14.3

5.3

0.50

(3012516) Albumin [Mass/volume] in Urine

138

3.35

5.85

5.0

2.7

mg/l

116.2

33.7

0.71

(3009508) Creatinine [Moles/volume] in Urine

146

3.12

5.22

5.1

2.6

mmol/l

7.5

8.2

0.47

120

(3032080) INR in Blood by Coagulation assay

237

2.98

4.95

13.2

6.8

inr

1.3

1.2

0.23

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.65

4.80

4.2

3.3

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

242

2.89

4.68

6.9

4.8

mmol/l

1.2

0.26

220

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

105

3.10

4.62

2.4

1.8

pmol/l

352.0

428.4

0.85

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

197

2.78

4.41

2.4

2.0

pmol/l

91.4

96.5

0.30

104

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

497

3.80

4.08

5.4

4.1

mu/l

2.0

1.9

0.29

443

(3018677) aPTT in Platelet poor plasma by Coagulation assay

3.03

3.75

2.5

1.8

29.5

29.4

0.05

(3023368) Bacteria identified in Blood by Culture

152

2.51

3.40

5.0

4.7

—

(3018418) pH of Serum or Plasma

153

2.49

3.34

5.1

3.4

7.4

0.34

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

132

2.51

3.23

2.0

1.6

mmol/l

2.9

1.4

1.03

108

(40761536) Microorganisms panel - Urine sediment

3.30

3.21

4.2

4.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

216

2.32

3.06

6.4

3.8

ng/l

23.8

57.4

1.04

154

(3012095) Magnesium [Moles/volume] in Serum or Plasma

2.62

3.02

2.4

4.1

mmol/l

0.9

0.8

0.91

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.85

2.88

1.0

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

266

2.23

2.83

4.7

3.6

estimate

0.0

0.00

(3035350) Ketones [Presence] in Urine by Test strip

260

2.19

2.72

4.7

3.6

estimate

0.0

0.00

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

208

2.19

2.68

4.3

3.7

—

(3013512) EKG study

175

2.21

2.65

7.4

3.4

—

(3002582) Erythrocytes [#/volume] in Urine

184

2.19

2.62

3.3

2.5

e6/l

7.8

406.7

0.55

134

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

6.60

2.41

1.0

—

(3030467) Casts [#/volume] in Urine by Automated count

166

2.11

2.33

3.4

2.5

e6/l

0.1

0.4

1.30

116

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

399

2.20

2.32

4.7

3.6

pmol/l

15.2

14.8

0.44

356

(3019198) Lymphocytes [#/volume] in Blood

290

2.06

2.32

6.2

6.0

e9/l

2.0

1.8

0.46

256

(3021601) Nitrite [Presence] in Urine by Test strip

263

2.04

2.29

6.4

4.6

estimate

0.0

0.00

(3044889) 12 lead EKG panel

391

2.15

2.25

4.7

3.9

—

(3021589) Normoblasts [#/volume] in Blood

255

2.02

2.25

15.7

10.6

e9/l

0.0

0.50

202

(3001604) Monocytes [#/volume] in Blood

283

2.02

2.24

6.2

5.9

e9/l

0.6

0.21

243

(3006315) Basophils [#/volume] in Blood

284

2.01

2.21

6.2

5.9

e9/l

0.0

0.01

244

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.97

2.20

1.4

1.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

364

2.05

2.15

6.4

3.9

—

(3018095) Leukocytes [#/volume] in Urine

199

1.97

2.04

4.4

3.0

e6/l

27.8

29.6

0.04

140

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.96

2.01

3.6

6.5

mmol/l

23.1

24.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

568

2.69

2.00

24.2

13.9

mg/l

26.3

23.8

0.25

445

(3049717) Cytology report of Urine Cyto stain

3.41

1.93

3.7

3.5

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

584

2.79

1.92

27.5

15.2

mmol/l

139.7

0.01

565

(3013115) Eosinophils [#/volume] in Blood

294

1.90

1.91

6.4

6.0

e9/l

0.2

0.29

253

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

169

1.95

1.88

3.4

3.1

ng/l

905.0

1296.6

0.42

144

(3012544) pH of Venous blood

2.58

1.88

7.6

2.9

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

598

3.00

1.87

27.9

16.4

umol/l

90.0

79.5

0.96

598

(40758558) Short blood count panel - Blood

137

1.99

1.84

4.6

6.4

—

(3002032) Base excess in Venous blood by calculation

2.52

1.80

7.8

2.9

mmol/l

-0.7

1.3

1.13

(36304419) Bacteria [Presence] in Urine

163

1.92

1.79

3.6

2.5

—

(3042936) Bacteria identified in Isolate by Culture

2.13

1.79

1.8

2.2

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

587

2.72

1.77

27.7

15.3

mmol/l

4.0

0.20

566

(42870588) Differential panel, method unspecified - Blood

191

1.86

1.71

6.2

5.9

—

(4034850)

3.34

1.70

22.0

14.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

576

2.52

1.69

6.8

4.7

mmol/l

2.4

2.8

2.19

529

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.87

1.62

2.9

2.2

0.6

0.7

—

(3029937) Albumin [Presence] in Urine by Test strip

151

1.88

1.62

4.7

4.0

estimate

0.0

0.00

(40761511) CBC panel - Blood by Automated count

595

2.53

1.61

27.1

12.8

—

(3000991) Gas panel - Venous blood

2.47

1.61

7.4

3.5

—

(1002224) Polysomnography panel

2.76

1.56

1.0

1.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.76

1.56

2.9

2.2

0.7

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

120

1.92

1.55

3.1

6.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

145

1.86

1.54

3.7

2.8

—

(3002385) Erythrocyte distribution width [Ratio]

464

1.89

1.46

23.9

16.8

14.0

13.9

0.19

455

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.42

1.46

7.0

6.2

kpa

5.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

563

2.11

1.42

6.4

4.3

mmol/l

1.1

1.4

6.66

516

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

247

1.70

1.39

6.2

3.8

—

(1761868) Lipid panel - Serum or Plasma

222

1.69

1.32

4.0

2.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.08

1.32

1.7

1.8

—

(3003694) ABO and Rh group [Type] in Blood

135

1.78

1.30

1.7

1.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

566

2.06

1.29

6.4

4.3

mmol/l

4.1

4.6

3.27

522

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

551

2.05

1.27

6.3

4.4

mmol/l

6.8

5.9

1.57

504

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.52

1.27

1.0

1.2

—

(3045414) Leukocytes [Presence] in Urine

2.75

1.23

1.4

1.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.24

1.23

1.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

554

2.00

1.21

5.6

3.9

mmol/l

2.1

1.3

2.07

503

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.61

1.17

1.0

1.8

—

(3022313) Gas panel - Capillary blood

2.47

1.16

8.0

6.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.07

1.12

2.5

1.5

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.95

1.05

1.9

2.6

g/l

0.2

0.66

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

1.75

1.00

3.1

2.4

e6/l

2.6

0.4

—

(3044640) Blood type and Crossmatch panel - Blood

181

1.58

0.98

4.1

2.3

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.77

0.88

28.2

20.7

—

1.3

—

(3026008) Bacteria identified in Urine by Culture

150

1.56

0.86

3.6

2.5

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

0.81

0.0

1.9

—

19.4

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.16

0.76

1.0

2.8

mmol/l

23.9

23.8

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.16

0.76

6.4

2.9

56.4

59.0

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

102

1.59

0.75

3.4

2.3

e6/l

1.5

0.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.61

0.73

2.4

2.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.63

0.73

2.7

1.5

—

(40768804) Tissue Pathology biopsy report

221

1.43

0.71

2.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

503

1.49

0.67

20.4

13.2

39.4

40.0

0.14

366

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

140

1.48

0.67

4.6

2.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.78

0.65

1.6

1.3

—

(3019060) Gas panel - Arterial blood

1.72

0.58

2.3

2.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.63

0.56

1.3

1.6

—

(4035726)

1.58

0.50

1.3

1.5

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

1.45

0.48

6.2

2.8

ng/l

85.1

257.4

0.73

(40761535) Cells panel - Urine sediment

1.47

0.47

10.0

3.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

124

1.37

0.43

5.9

4.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.55

0.42

3.0

2.1

—

(3008898) HLA-B27 [Presence]

0.00

0.41

0.0

1.1

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.5

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.50

0.41

2.2

3.4

87.8

93.7

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.46

0.40

2.2

3.3

0.7

—

(40768797) Stomach Pathology biopsy report

1.42

0.39

1.1

1.3

—

(3022621) pH of Urine by Test strip

1.47

0.36

1.5

2.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

119

1.33

0.35

1.9

1.6

mg/l

1.0

0.9

—

(3000494) Fungus identified in Specimen by Culture

1.39

0.32

1.4

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.69

0.27

4.6

8.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.27

0.27

2.9

1.5

—

(3002256) Pathology report gross observation

1.21

0.26

1.7

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.30

0.23

2.0

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

321

1.17

0.22

2.8

3.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.21

0.0

2.7

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.24

0.20

2.2

u/l

27.5

33.2

—

(3019225) pH of Specimen

1.25

0.19

13.4

3.7

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

101

1.23

0.18

1.2

1.3

u/ml

1.0

2.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.20

0.17

1.3

1.9

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

237

1.15

0.17

4.1

4.6

25.9

22.3

0.50

111

(3022145) Colonoscopy Study observation

1.16

0.17

1.0

1.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.76

0.16

1.8

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.09

0.10

2.6

1.5

—

(21494755) Public health laboratory ask at order entry panel

0.82

0.08

1.4

1.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.98

0.00

1.3

1.9

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(44790047)

0.00

0.0

2.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.4

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.0

—

(3000492) Spirometry study

0.96

0.00

1.4

1.3

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.9

—

(44790048)

0.00

0.0

2.2

—

(3041008) Bicarbonate [Moles/volume] standard in Arterial cord blood

0.00

0.0

1.0

—

19.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.8

—

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

0.00

0.0

1.0

—

171.4

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.0

—

26.5

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

4.1

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.93

0.00

4.2

ug/l

2.7

6.1

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

10.8

—

791.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3006598) pH of Arterial cord blood

0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.89

0.00

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

5.7

—

19.6

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.8

—

13.0

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

18.0

—

1121.6

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(44806118)

0.00

0.0

2.2

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.02

0.00

1.4

2.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.0

—

(44790049)

0.00

0.0

2.2

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3004959) Base excess in Arterial cord blood by calculation

0.00

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_LIPODEF and mortality.

Females

Parameter	HR [95% CI]	p-value
E4_LIPODEF	2.042 [1.38, 3.01]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.377

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 249 females with E4_LIPODEF died.

Males

Parameter	HR [95% CI]	p-value
E4_LIPODEF	2.28 [1.56, 3.33]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.006

During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 343 males with E4_LIPODEF died.

Mortality risk

Mortality risk for people of age

years, who have E4_LIPODEF.

N-year risk	Females	Males
1	0.166%	0.293%
5	1.201%	2.475%
10	3.159%	6.698%
15	5.917%	12.738%
20	10.015%	20.311%

Relationships between endpoints

↥

Index endpoint: E4_LIPODEF – Lipoprotein deficiency

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	E4_LIPODEF
CONTROL_EXCLUDE	E4_METABOLIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E786
HD_ICD_9	2725
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E786
COD_ICD_9	2725
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Lipoprotein deficiency

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints