No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
73 |
4. Check minimum number of eventsNone |
73 |
5. Include endpointsNone |
73 |
6. Filter based on genotype QC (FinnGen only) |
73 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E78
- Name in latin
- Deficientia lipoproteinorum
Similar endpoints
↥List of similar endpoints to
Lipoprotein deficiency
based on the number of shared cases.
Similar with more cases:
- Disorders of lipoprotein metabolism and other lipidaemias
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 675 | 279 | 394 |
| Only index persons | 614 | 256 | 358 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 65.75 | 68.29 | 63.94 |
| Only index persons | 65.71 | 68.17 | 63.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 73 | 23 | 50 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 60.76 | 60.01 | 61.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 66
- Matched controls
- 658
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E78.63
ICD-10 Finland
Low HDL syndrome
+∞
45.0
38
*
E78.69
ICD-10 Finland
Lipoprotein deficiency, other or unspecified
+∞
11.8
11
*
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
9.8
9.7
20
28
C07AB07
ATC
bisoprolol; oral
5.1
8.9
45
195
E78.6
ICD-10 Finland
Lipoprotein deficiency
+∞
8.5
8
*
E87.6
ICD-10 Finland
Hypokalaemia
+∞
8.5
8
*
C10AA05
ATC
atorvastatin; oral
4.8
8.5
40
160
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
51.3
7.9
9
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
5.1
7.8
28
83
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
89.8
7.6
8
*
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
14.3
7.4
12
10
I10
ICD-10 Finland
Essential (primary) hypertension
4.4
7.0
51
286
T90
ICPC
Diabetes non-insulin dependent
4.5
6.6
26
83
E78.61
ICD-10 Finland
Abetalipoproteinaemia
+∞
6.3
6
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.7
6.1
40
194
Mortality – FinRegistry
↥Association
Association between endpoint E4_LIPODEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_LIPODEF | 2.042 [1.38, 3.01] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.377 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 249 females with E4_LIPODEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_LIPODEF | 2.28 [1.56, 3.33] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 343 males with E4_LIPODEF died.
Mortality risk
Mortality risk for people of age
years, who have E4_LIPODEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.166% | 0.293% |
| 5 | 1.201% | 2.475% |
| 10 | 3.159% | 6.698% |
| 15 | 5.917% | 12.738% |
| 20 | 10.015% | 20.311% |
Relationships between endpoints
↥Index endpoint: E4_LIPODEF – Lipoprotein deficiency
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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