No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
147 |
4. Check minimum number of eventsNone |
147 |
5. Include endpointsNone |
147 |
6. Filter based on genotype QC (FinnGen only) |
126 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Short stature starting before birth
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 126 | 64 | 62 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 5.76 | 4.97 | 6.59 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 147
- Matched controls
- 1470
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E34.31
ICD-10 Finland
Short stature, prenatal disorder
3287.9
125.2
103
*
H01AC01
ATC
somatropin; parenteral
50.6
119.1
79
33
101
Kela drug reimbursment
Anterior pituitary hypofunction
35.3
63.7
43
17
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
12.9
52.9
69
94
2594A
ICD-9 Finland
Other endocrine disorders, Dwarfism, not elsewhere classified
+∞
52.2
47
*
301
Kela drug reimbursment
Growth hormone
52.4
33.2
39
10
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
12.9
30.0
32
31
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
9.5
23.9
32
42
E34.30
ICD-10 Finland
Short stature NOS
33.8
23.4
30
11
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
20.3
20.8
31
19
602
Kela drug reimbursment
Children's severe malnutrition
7.9
20.6
32
50
E34.35
ICD-10 Finland
Abnormal growth retardation
9.0
19.8
27
36
P05.1
ICD-10 Finland
Small for gestational age
18.3
16.9
26
17
Z31.5
ICD-10 Finland
Genetic counselling
5.4
14.9
34
77
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.3
14.6
49
152
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
11.6
12.5
23
23
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
33.1
11.9
15
5
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
+∞
10.5
10
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
5.0
7.9
18
40
P07.3
ICD-10 Finland
Other preterm infants
4.6
7.5
19
46
Q87.19
ICD-10 Finland
Congenital malformation syndromes predominantly associated with short stature
84.2
7.5
8
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
42.0
6.8
8
*
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
8.5
6.8
14
18
R62.0
ICD-10 Finland
Delayed milestone
3.7
6.7
23
70
Z3229
NOMESCO Finland
Other healthcare associate professional
3.1
6.4
31
118
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
38
28
17.95
42.42
6.4
6.4
2.26
2.62
ug/l
0.20
38
28
36
124
3.52
8.89
2.8
2.5
3.40
5.97
u/l
1.38
23
73
33
111
3.54
8.43
3.0
2.6
5.14
8.27
iu/l
1.02
23
71
103
655
2.91
8.24
3.7
3.6
32.84
37.21
mmol/mol
10.57
103
627
40
174
2.78
6.51
2.3
3.0
289.13
326.37
nmol/l
0.65
40
169
116
870
2.58
5.35
4.5
3.9
14.24
14.31
pmol/l
0.12
116
823
123
992
2.47
4.11
4.8
4.2
1.97
1.96
mu/l
0.01
123
944
39
211
2.15
3.79
2.1
1.6
107.33
96.11
pmol/l
0.81
21
108
6
6
10.35
3.53
1.3
1.5
616.50
363.50
mu/l
—
6
6
6
6
10.35
3.53
1.3
1.5
75.00
73.83
%
—
6
6
25
117
2.37
3.40
3.1
1.9
7.72
11.27
nmol/l
1.35
25
103
7
11
6.62
3.22
2.0
1.5
0.72
2.83
mg/l
—
7
6
7
11
6.62
3.22
2.0
1.5
0.24
0.53
mg/l
—
7
5
7
11
6.62
3.22
2.0
1.5
1.36
9.27
mg/l
—
7
6
7
11
6.62
3.22
2.0
1.5
0.26
6.29
mg/l
—
7
6
10
29
3.62
2.75
4.1
5.2
18.30
22.45
umol/l
—
10
29
39
569
0.57
2.31
1.8
2.0
—
—
—
0
0
11
42
2.75
2.19
1.4
1.9
3.83
3.66
umol/l
0.06
11
36
100
832
1.63
2.01
12.5
13.6
3.61
3.60
e9/l
0.02
85
693
11
45
2.56
1.98
1.9
1.4
—
—
—
0
0
6
17
3.63
1.85
1.0
1.2
—
—
—
0
0
9
36
2.60
1.77
2.3
1.2
—
—
—
0
0
24
144
1.80
1.71
2.7
5.9
0.20
0.21
g/l
0.31
24
138
67
531
1.48
1.53
1.8
1.9
0.53
4.45
u/ml
—
8
91
11
52
2.21
1.48
1.4
1.1
—
—
—
0
0
9
41
2.27
1.39
2.8
1.9
—
—
—
0
0
5
17
3.01
1.37
2.6
2.0
—
—
—
0
0
23
147
1.67
1.33
2.6
2.0
—
—
—
0
0
5
18
2.84
1.29
1.0
1.1
—
—
—
0
0
7
141
0.47
1.29
1.3
1.5
—
—
—
0
0
16
258
0.57
1.28
3.0
2.2
—
—
—
0
0
14
79
1.85
1.22
1.4
1.3
421.14
94366694.51
pmol/l
0.49
14
71
74
620
1.39
1.16
7.9
5.8
113.47
105.80
ml/min/173m2
1.40
53
421
5
20
2.55
1.16
1.0
1.1
—
—
—
0
0
8
40
2.06
1.14
2.4
2.4
—
—
—
0
0
11
60
1.90
1.06
1.4
1.1
—
16.34
—
0
9
5
22
2.32
1.04
1.0
1.0
—
—
—
0
0
6
27
2.27
0.94
1.0
1.0
—
—
—
0
0
19
127
1.57
0.94
1.2
1.2
23.08
13.00
iu/ml
—
6
31
8
42
1.96
0.90
4.4
3.6
—
—
—
0
0
8
42
1.96
0.90
1.4
1.1
—
13.55
—
0
15
10
166
0.57
0.90
2.0
2.0
—
—
—
0
0
6
113
0.51
0.87
2.2
2.1
—
—
—
0
0
6
31
1.97
0.85
1.0
2.3
—
—
—
0
0
18
122
1.54
0.85
2.7
2.0
—
—
—
0
0
8
47
1.74
0.82
2.4
2.3
—
—
—
0
0
8
47
1.74
0.82
2.4
2.3
—
—
—
0
0
8
48
1.70
0.80
9.1
15.3
—
493.10
—
0
10
6
34
1.80
0.77
2.8
1.5
—
—
—
0
0
9
53
1.74
0.77
7.9
3.7
32.33
28.89
%
—
9
53
18
125
1.50
0.77
2.6
1.9
—
—
—
0
0
5
24
2.12
0.75
3.2
1.7
—
—
—
0
0
5
24
2.12
0.75
1.2
1.2
94.60
76.83
%
—
5
24
9
55
1.68
0.75
2.2
2.3
—
—
—
0
0
9
56
1.65
0.74
7.8
4.0
10.00
8.88
%
—
9
56
9
56
1.65
0.74
7.8
4.0
—
—
—
0
0
9
57
1.62
0.72
2.2
2.5
—
—
—
0
0
21
153
1.43
0.72
2.5
2.1
12.48
26.50
ng/l
—
10
63
5
26
1.95
0.71
1.6
1.4
—
—
—
0
0
115
1216
0.75
0.67
16.9
11.8
25.52
24.36
mg/l
0.13
81
831
6
101
0.58
0.65
1.7
1.3
—
—
—
0
0
29
229
1.33
0.63
2.1
3.2
56.03
59.55
u/l
0.20
29
217
40
332
1.28
0.61
3.3
3.4
—
—
—
0
0
34
277
1.30
0.60
7.3
4.4
1.14
1.13
inr
—
8
68
121
1145
1.32
0.59
10.0
9.8
27.27
27.99
u/l
0.17
121
1113
0
23
0.00
0.59
0.0
1.1
—
—
—
0
0
6
35
1.74
0.58
2.7
2.5
—
—
—
0
0
57
499
1.23
0.56
4.1
3.5
0.00
0.00
estimate
—
5
88
6
38
1.60
0.55
2.2
2.4
—
—
—
0
0
22
278
0.75
0.54
2.7
2.4
—
—
—
0
0
15
109
1.42
0.53
29.6
13.8
106.93
105.39
mmol/l
0.52
15
109
56
498
1.20
0.46
6.0
5.1
0.00
0.00
estimate
—
5
89
7
50
1.42
0.45
1.9
1.5
—
—
—
0
0
8
58
1.40
0.42
1.1
1.5
—
—
—
0
0
8
58
1.40
0.42
1.1
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
25.59
—
0
8
0
15
0.00
0.41
0.0
2.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
7.75
—
0
8
0
15
0.00
0.41
0.0
1.1
—
141.80
—
0
15
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
15
0.00
0.41
0.0
1.1
—
93.87
—
0
15
0
16
0.00
0.41
0.0
1.8
—
6.19
—
0
16
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
7
102
0.67
0.41
1.4
1.5
—
—
—
0
0
56
503
1.18
0.40
4.1
3.6
0.00
0.00
estimate
—
5
84
29
244
1.23
0.40
3.9
3.8
0.00
0.00
estimate
—
5
87
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
18
0.00
0.40
0.0
1.2
—
127.22
—
0
18
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
8
114
0.68
0.39
1.5
1.2
—
—
—
0
0
6
42
1.45
0.36
2.2
2.4
—
93.43
—
0
14
6
43
1.41
0.35
2.8
2.4
—
—
—
0
0
6
43
1.41
0.35
2.8
2.4
—
—
—
0
0
16
127
1.29
0.35
27.9
13.7
1.61
1.45
mmol/l
0.16
16
121
6
45
1.35
0.34
24.7
13.6
0.85
0.74
%
—
6
45
6
89
0.66
0.34
2.3
2.1
—
78.81
—
0
7
10
132
0.74
0.34
1.7
2.0
—
—
—
0
0
6
46
1.32
0.33
24.7
13.3
0.92
1.11
%
—
6
46
6
46
1.32
0.33
10.0
15.0
—
344.11
—
0
9
8
65
1.24
0.27
1.6
2.0
—
—
—
0
0
36
322
1.16
0.27
14.8
11.7
0.37
1.03
mmol/l
0.60
28
254
5
71
0.69
0.27
1.0
1.2
—
—
—
0
0
38
343
1.15
0.25
23.1
13.6
24.79
24.97
mmol/l
0.16
38
343
17
144
1.20
0.23
4.2
3.3
3080.00
1028.00
ng/l
—
9
84
25
282
0.86
0.23
4.1
3.4
—
—
—
0
0
5
40
1.26
0.22
4.8
7.1
43.92
58.01
%
—
5
40
29
323
0.87
0.22
18.3
9.2
5.23
5.02
kpa
0.83
29
311
0
11
0.00
0.21
0.0
1.3
—
103.82
—
0
11
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
41.18
—
0
11
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
29
322
0.88
0.21
18.1
9.2
0.63
1.05
mmol/l
0.25
21
232
0
12
0.00
0.21
0.0
1.0
—
2.50
—
0
7
0
12
0.00
0.21
0.0
1.0
—
163.22
—
0
12
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
33
299
1.13
0.21
15.1
11.3
23.27
23.69
mmol/l
0.53
33
299
0
13
0.00
0.21
0.0
3.7
—
57.15
—
0
13
0
14
0.00
0.20
0.0
1.0
—
86.78
—
0
9
0
14
0.00
0.20
0.0
1.0
—
87.00
—
0
9
21
237
0.87
0.19
6.2
4.1
1.14
0.46
e6/l
0.59
12
139
42
449
0.91
0.16
3.9
3.4
—
—
—
0
0
22
242
0.89
0.14
6.2
4.1
1.25
1.48
e6/l
0.13
13
146
5
43
1.17
0.10
2.0
1.0
—
67.17
—
0
12
5
43
1.17
0.10
2.6
5.8
—
—
—
0
0
16
175
0.90
0.09
1.0
1.1
—
—
—
0
0
6
56
1.07
0.09
2.5
5.9
333.33
336.80
mg/l
—
6
56
122
1236
0.92
0.09
4.4
4.1
—
—
—
0
0
7
80
0.87
0.07
1.4
1.4
—
—
—
0
0
13
119
1.10
0.06
1.1
1.2
0.76
5.29
u/ml
—
5
40
37
380
0.96
0.03
5.9
4.6
0.04
0.20
e6/l
1.63
29
289
13
122
1.07
0.03
3.9
10.9
101.31
91.87
%
0.86
13
122
10
107
0.93
0.02
2.5
2.9
22.90
36.00
u/l
—
10
101
71
718
0.98
0.01
2.4
2.4
5.08
5.50
mmol/l
5.78
66
663
10
96
1.04
0.00
2.8
1.7
—
—
—
0
0
12
124
0.96
0.00
1.8
1.5
—
—
—
0
0
20
201
0.99
0.00
2.8
6.0
3.24
2.60
mg/l
0.15
14
148
42
424
0.99
0.00
6.0
5.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
44.50
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.00
—
0
5
0
5
0.00
-0.00
0.0
3.0
—
4.80
—
0
5
0
5
0.00
-0.00
0.0
4.0
—
11.26
—
0
5
0
7
0.00
-0.00
0.0
7.3
—
—
—
0
0
9
93
0.97
-0.00
1.7
1.2
—
—
—
0
0
7
76
0.92
-0.00
1.3
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.00
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
13.02
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
0.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
0.00
—
0
5
7
73
0.96
-0.00
1.1
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
2.8
5.8
3.30
3.26
mmol/l
—
5
53
0
6
0.00
-0.00
0.0
1.0
—
39.91
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.08
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
0.94
—
0
6
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: E4_SHORT_STATURE_STARTING_BEFORE_BIRTH – Short stature starting before birth
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).