Enteropathogenic Escherichia coli infection

ENTEROPATH_E_COLI

dysentery: Acute inflammation of the intestine associated with infectious diarrhea of various etiologies, generally acquired by eating contaminated food containing toxins, biological derived from bacteria or other microorganisms. Dysentery is characterized initially by watery feces then by bloody mucoid stools. It is often associated with abdominal pain; fever; and dehydration.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A04.0 Cause of death: ICD-10 — A04.0 2 out of 7 registries used, show all original rules.	117
4. Check minimum number of events None	117
5. Include endpoints None	117
6. Filter based on genotype QC (FinnGen only)	110

Control definitions (FinnGen only)

Control exclude: IBD_BACT_INTEST_INFECTIONS

Extra metadata

First used in FinnGen datafreeze: DF2
Parent code in ICD-10: A04
Name in latin: Infectio ab Escherichia coli enteropathogenica

NAME	ENTEROPATH_E_COLI
CONTROL_EXCLUDE	IBD_BACT_INTEST_INFECTIONS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A040
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A040
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Enteropathogenic Escherichia coli infection based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	847	440	403
Only index persons	730	388	342
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	59.41	61.54	56.93
Only index persons	58.07	59.97	55.91

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	110	53	57
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	63.89	62.90	64.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
117: Matched controls
1170

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A04.0

ICD-10 Finland

Enteropathogenic Escherichia coli infection

+∞

168.9

117

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

6.6

22.6

135

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.9

11.9

A04.7

ICD-10 Finland

Enterocolitis due to Clostridium difficile

120.4

10.6

J01MA02

ATC

ciprofloxacin; systemic

3.5

10.1

302

A04.5

ICD-10 Finland

Campylobacter enteritis

+∞

9.5

R50.9

ICD-10 Finland

Fever, unspecified

3.8

9.2

118

A49.9

ICD-10 Finland

Bacterial infection, unspecified

4.1

8.6

ZXD05

NOMESCO Finland

Urgent procedure

3.0

7.7

224

Z2221

NOMESCO Finland

Medical doctor

3.0

7.5

213

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

4.8

7.0

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.9

6.9

193

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

8.7

6.8

TPH04

NOMESCO Finland

Cathetrisation of vein

3.0

6.6

163

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

10.36

30.22

2.0

1.6

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

13.68

15.51

1.4

1.2

—

(3000991) Gas panel - Venous blood

4.66

11.02

9.8

9.3

—

(3002032) Base excess in Venous blood by calculation

4.45

10.86

5.2

7.1

2.36

1.89

mmol/l

0.35

(3003327) Ova and parasites identified in Stool by Light microscopy

6.11

10.01

2.3

1.3

—

(3023368) Bacteria identified in Blood by Culture

260

3.44

9.89

7.1

4.3

—

(3025941) Bacteria identified in Stool by Culture

5.23

9.26

1.4

1.1

—

(3013115) Eosinophils [#/volume] in Blood

483

3.47

8.88

10.9

7.7

0.24

0.19

e9/l

0.69

429

(3048689) Calprotectin [Mass/mass] in Stool

126

3.54

8.23

2.9

2.4

507.10

112.64

ug/g

1.37

(3006315) Basophils [#/volume] in Blood

470

3.22

8.13

10.6

7.3

0.04

e9/l

0.37

409

(3001604) Monocytes [#/volume] in Blood

470

3.22

8.13

10.6

7.3

0.64

0.58

e9/l

0.77

410

(3018418) pH of Serum or Plasma

285

3.05

8.11

8.5

3.9

7.36

7.40

—

(3018095) Leukocytes [#/volume] in Urine

342

3.03

8.01

5.3

3.9

17.25

61.31

e6/l

1.62

239

(3026782) Osmolality of Urine

193

3.16

7.95

2.7

3.0

519.59

552.56

mosm/kgh2o

0.44

163

(3002582) Erythrocytes [#/volume] in Urine

297

2.99

7.83

4.4

3.3

16.16

274.15

e6/l

0.61

223

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

339

2.96

7.71

5.0

3.4

—

(3019198) Lymphocytes [#/volume] in Blood

483

3.08

7.51

10.8

7.3

2.14

1.85

e9/l

0.55

436

(3013650) Neutrophils [#/volume] in Blood by Automated count

550

3.13

7.10

20.9

11.1

4.04

4.15

e9/l

0.19

487

(3014576) Chloride [Moles/volume] in Serum or Plasma

121

3.26

6.87

11.2

7.6

103.03

103.64

mmol/l

0.28

121

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

109

3.36

6.86

2.7

1.7

—

(40758558) Short blood count panel - Blood

259

2.81

6.84

17.4

8.4

—

(3021589) Normoblasts [#/volume] in Blood

443

2.82

6.80

11.8

11.4

0.00

e9/l

0.71

363

(3007164) IgA [Mass/volume] in Serum or Plasma

185

2.87

6.44

1.4

1.6

2.08

2.46

g/l

0.43

115

(36304419) Bacteria [Presence] in Urine

268

2.69

6.30

4.5

3.1

—

(3030467) Casts [#/volume] in Urine by Automated count

277

2.67

6.23

4.4

3.2

0.33

0.30

e6/l

0.09

206

(40760892) CBC W Ordered Manual Differential panel - Blood

447

2.68

6.21

9.9

8.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

112

3.11

5.95

2.8

1.8

—

(3022096) Basophils/100 leukocytes in Blood

420

2.57

5.81

10.3

7.7

0.64

0.65

0.08

386

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

450

2.56

5.69

13.5

7.7

1.20

1.21

mmol/l

0.61

383

(3004716) Salmonella sp identified in Stool by Organism specific culture

3.97

5.56

1.7

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

5.39

5.34

1.5

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

5.39

5.34

1.5

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

5.39

5.34

1.5

1.1

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

211

2.55

5.20

6.0

3.9

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

168

2.65

5.17

4.4

3.0

0.82

0.98

e6/l

0.18

(3013139) Helicobacter pylori Ag [Presence] in Stool

3.51

4.70

1.1

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

162

2.55

4.64

2.9

1.9

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

207

2.42

4.57

1.5

1.3

1.16

1.07

u/ml

0.04

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.55

4.53

2.2

1.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

4.91

4.40

1.2

1.1

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

6.72

4.40

1.4

1.7

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

6.72

4.40

1.4

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

152

2.52

4.37

4.7

3.2

1.56

2.53

e6/l

0.38

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.32

4.33

5.2

5.7

126.00

128.47

g/l

0.18

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

6.32

4.23

1.1

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.97

4.15

1.5

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

5.97

4.07

1.3

1.8

—

(3023520) Reticulocytes [#/volume] in Blood

2.93

4.06

3.6

5.1

62.89

67.86

e9/l

0.33

(3027273) Bicarbonate [Moles/volume] in Venous blood

3.56

4.05

6.1

3.6

24.26

24.57

mmol/l

0.12

(3031040) Bacteria [#/volume] in Urine by Automated count

597

2.25

3.91

7.3

4.5

29.50

409.78

e6/l

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

3.29

3.85

5.9

5.0

0.84

0.67

1.00

(3035350) Ketones [Presence] in Urine by Test strip

454

2.11

3.80

5.8

3.7

0.00

estimate

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

12.54

3.80

1.2

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

12.54

3.80

1.2

1.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

455

2.11

3.77

7.5

5.2

0.00

estimate

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

305

2.12

3.73

6.2

3.1

29.10

33.87

u/l

0.82

287

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

4.05

3.73

5.2

2.5

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

2.72

3.73

3.1

2.8

0.20

0.22

g/l

0.84

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.83

3.68

7.0

4.9

106.50

76.97

ng/l

0.38

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

3.16

3.62

5.9

4.9

1.15

1.40

0.39

(3009261) Glucose [Presence] in Urine by Test strip

461

2.06

3.58

5.8

3.8

0.00

estimate

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.25

3.55

7.2

3.0

50.59

51.09

0.02

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.28

3.37

1.1

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

367

2.01

3.36

1.9

2.0

101.25

91.63

pmol/l

0.94

183

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.98

3.30

1.9

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

434

1.98

3.25

2.9

2.5

—

(3015736) pH of Urine

372

1.97

3.19

6.0

3.7

5.83

5.84

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

4.27

3.17

1.0

1.8

—

(3044941) Cell count panel - Synovial fluid

7.83

3.09

1.2

1.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

184

2.11

3.03

1.8

1.9

—

(3003396) Base excess in Arterial blood by calculation

104

2.37

2.98

11.1

7.2

2.24

1.32

mmol/l

0.85

(3044640) Blood type and Crossmatch panel - Blood

292

1.95

2.95

3.1

2.3

—

(3019060) Gas panel - Arterial blood

2.69

2.94

4.1

3.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

226

2.01

2.93

2.6

2.2

—

(3000093) Morphology [Interpretation] in Blood Narrative

5.65

2.91

1.0

1.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

6.95

2.90

1.0

—

(3026008) Bacteria identified in Urine by Culture

285

1.94

2.89

4.2

2.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

114

2.27

2.80

2.0

1.8

—

(3020891) Body temperature

3.22

2.79

10.3

3.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

124

2.18

2.65

1.5

1.6

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.58

4.5

1.9

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.28

2.55

2.5

1.8

391.30

368.39

nmol/l

0.18

(40761535) Cells panel - Urine sediment

2.41

2.52

5.7

3.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

640

1.86

2.46

6.0

4.4

—

(3021788) Differential panel - Synovial fluid

5.20

2.43

1.7

1.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

4.07

2.29

1.4

1.3

—

(3000492) Spirometry study

2.35

2.27

1.7

1.6

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.47

2.25

14.6

8.1

90.48

93.72

0.46

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

5.74

2.23

1.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

5.74

2.23

1.4

1.6

—

(3037756) Immunofixation for Serum or Plasma

3.50

2.22

1.6

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

580

1.75

2.19

3.9

3.0

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

3.85

2.18

1.7

7.5

—

4920.00

—

(3003338) MCHC [Mass/volume]

760

1.89

2.15

45.8

19.9

330.05

333.20

g/l

2.53

755

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

4.15

2.06

1.0

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

4.15

2.06

2.5

6.9

21.67

33.20

mg/l

—

(21494890) Protein electrophoresis panel - 24 hour Urine

4.69

1.96

1.4

1.5

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

3.66

1.86

1.5

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

347

1.65

1.83

6.5

3.8

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

175

1.79

5.3

3.5

264.04

111.96

ng/l

0.26

143

(3044889) 12 lead EKG panel

619

1.65

1.78

4.0

4.1

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

2.43

1.76

2.9

3.3

0.00

0.10

e6/l

2.21

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.03

1.75

1.3

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

3.03

1.75

10.6

3.3

47.80

26.59

mg/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

849

1.83

1.68

26.0

13.5

82.19

81.96

ml/min/173m2

0.03

677

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

154

1.79

1.67

1.7

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

214

1.68

1.62

1.5

2.0

1.23

1.01

mg/l

0.34

169

(3003181) Sodium [Moles/volume] in Urine

3.10

1.60

2.5

1.3

72.67

67.85

mmol/l

—

(3029937) Albumin [Presence] in Urine by Test strip

243

1.63

1.53

7.4

3.9

0.00

estimate

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

2.95

1.52

1.8

1.4

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.59

1.47

1.0

1.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.50

1.41

1.0

1.6

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

250

0.54

1.40

2.3

1.6

1.04

1.40

mmol/l

1.94

211

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.08

1.38

15.6

10.9

26.33

24.58

mmol/l

1.47

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

173

1.65

1.33

1.6

1.5

—

(3022145) Colonoscopy Study observation

1.86

1.33

1.8

1.4

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

2.58

1.32

12.2

3.3

64.65

330.22

mg/l

—

(3014051) Protein [Presence] in Urine by Test strip

2.58

1.32

1.8

1.9

—

(40768797) Stomach Pathology biopsy report

116

1.76

1.31

1.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.85

1.30

1.0

1.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.47

1.26

1.7

1.3

—

(40768804) Tissue Pathology biopsy report

355

1.49

1.23

2.2

2.1

—

(3024928) Oxygen saturation in Venous blood

2.70

1.23

3.0

10.0

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

690

1.50

1.22

4.4

4.0

14.91

14.92

pmol/l

0.01

612

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

188

1.57

1.15

1.7

467.14

472.62

pmol/l

0.02

158

(3045414) Leukocytes [Presence] in Urine

2.00

0.99

1.9

1.6

—

(3000330) Specific gravity of Urine by Test strip

1.83

0.97

3.2

3.7

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.29

0.95

1.8

1.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

836

1.47

0.91

5.4

4.8

1.78

1.94

mu/l

0.79

752

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

355

1.38

0.89

5.1

3.8

33.87

35.30

ng/l

0.05

264

(3000494) Fungus identified in Specimen by Culture

113

1.59

0.88

1.3

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

100

926

1.55

0.88

36.5

14.9

30.98

23.49

mg/l

1.22

743

(36660697) Celiac disease serology panel - Serum

1.74

0.82

1.1

1.2

—

(3042936) Bacteria identified in Isolate by Culture

150

1.49

0.80

2.3

1.8

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.86

0.80

1.0

1.6

—

(3022621) pH of Urine by Test strip

1.76

0.78

2.2

2.1

—

(3034770) Mitochondria Ab [Titer] in Serum

2.22

0.77

1.0

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.04

0.73

1.0

1.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.57

0.73

1.7

1.6

—

(3036489) Thrombin time

1.80

0.72

2.3

3.3

31.57

21.75

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.82

0.67

1.0

1.1

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.82

0.67

1.0

2.5

—

(40768793) Breast Pathology biopsy report

0.00

0.60

0.0

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.55

0.60

1.3

1.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

178

1.36

0.59

1.7

1140.94

1201.43

nmol/l

0.13

141

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.59

0.0

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

111

1.40

0.49

1.3

1.7

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

111

1.40

0.49

1.8

1.9

1.35

1.51

0.48

(3022217) INR in Platelet poor plasma by Coagulation assay

440

1.24

0.49

17.8

14.8

1.19

1.28

inr

—

134

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.49

0.48

25.6

7.8

—

(3009343) pH of Capillary blood

1.49

0.46

2.4

4.3

—

7.44

—

(3022313) Gas panel - Capillary blood

1.49

0.44

2.6

4.4

—

(3052851) Hemolysis interference index of Serum or Plasma

1.59

0.43

2.8

3.1

—

(3017181) Myelocytes/100 leukocytes in Blood

1.43

0.42

4.1

4.9

1.40

0.82

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.38

0.42

1.5

2.2

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.40

0.0

2.8

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.45

0.40

1.6

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.64

0.37

2.4

1.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

248

1.23

0.36

4.5

3.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.45

0.36

1.7

1.9

—

(3013512) EKG study

283

0.81

0.36

3.4

4.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.38

0.35

1.7

2.1

—

(3003694) ABO and Rh group [Type] in Blood

270

1.20

0.33

1.3

1.5

—

(21494755) Public health laboratory ask at order entry panel

1.31

0.29

1.3

1.5

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

822

1.17

0.28

6.9

5.7

41.70

39.84

mmol/mol

1.14

762

(4200892) Spirometry reversibility

1.31

0.27

1.4

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

105

1.27

0.26

1.7

2.2

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

894

0.86

0.26

5.0

4.5

4.44

4.52

mmol/l

0.29

835

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

115

1.25

0.25

2.1

2.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

278

1.16

0.23

4.4

3.8

12.73

12.66

mg/mmol

0.00

174

(40761511) CBC panel - Blood by Automated count

961

1.20

0.23

24.7

13.6

—

(1761868) Lipid panel - Serum or Plasma

312

0.87

0.22

4.8

2.9

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

1.3

—

92.33

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

0.21

0.0

1.9

—

(4146454) Self-monitoring of blood glucose

0.00

0.21

0.0

3.9

—

(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.21

0.0

1.2

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.21

0.0

1.6

—

5.45

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.8

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.2

—

137.52

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.1

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.21

0.0

3.0

—

63.23

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.26

0.20

1.2

1.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.24

0.20

3.8

2.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

888

0.88

0.19

4.9

4.5

1.41

1.45

mmol/l

0.39

822

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

273

1.13

0.18

3.4

4.3

26.91

21.11

0.47

135

(40761536) Microorganisms panel - Urine sediment

0.77

0.16

4.2

3.5

—

(3009508) Creatinine [Moles/volume] in Urine

296

1.11

0.15

5.0

3.4

8.26

7.85

mmol/l

0.17

249

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

153

1.13

0.12

1.4

1.2

48.08

25.80

iu/ml

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

115

1.15

0.11

24.9

8.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

872

1.09

0.10

4.9

4.6

6.07

5.93

mmol/l

0.47

795

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.12

0.10

1.2

2.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.87

0.07

1.9

1.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

910

0.95

0.03

5.5

5.0

2.60

2.65

mmol/l

0.20

841

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

860

0.96

0.03

4.6

4.0

1.27

1.28

mmol/l

0.03

793

(3002256) Pathology report gross observation

112

0.98

0.00

1.2

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

194

0.98

0.00

2.2

2.9

0.90

0.70

ug/l

0.29

129

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

3.3

—

32.89

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.2

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

0.0

1.8

—

7.38

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

11.80

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

2.8

—

2.21

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

3.2

—

110.80

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(4062490) Immunoglobulin typing, IgG

0.00

0.0

1.2

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.8

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.3

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

2.1

—

13.67

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(4035726) Immunohistochemistry procedure

0.95

-0.00

1.1

1.4

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

11.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.4

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

1.50

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3017732) Neutrophils [#/volume] in Blood

0.93

-0.00

5.7

2.3

3.22

3.93

e9/l

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

-0.00

0.0

1.7

—

17.58

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.93

-0.00

6.1

3.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

28.73

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

110

1.00

-0.00

1.5

1.4

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.2

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.00

-0.00

2.2

2.3

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.2

—

(3012565) Volume of 24 hour Urine

0.00

-0.00

0.0

2.3

—

2092.86

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

3.1

—

79.71

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3015183) Erythrocyte sedimentation rate

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint ENTEROPATH_E_COLI and mortality.

Females

Parameter	HR [95% CI]	p-value
ENTEROPATH_E_COLI	2.339 [1.61, 3.41]	< 0.001
Birth year	1.0 [0.99, 1.01]	0.938

During the follow-up period (1.1.1998 — 31.12.2019), 122 out of 367 females with ENTEROPATH_E_COLI died.

Males

Parameter	HR [95% CI]	p-value
ENTEROPATH_E_COLI	2.601 [1.56, 4.34]	< 0.001
Birth year	0.982 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 334 males with ENTEROPATH_E_COLI died.

Mortality risk

Mortality risk for people of age

years, who have ENTEROPATH_E_COLI.

N-year risk	Females	Males
1	0.256%	0.401%
5	1.533%	2.463%
10	3.763%	6.297%
15	7.396%	12.017%
20	12.958%	19.635%

Relationships between endpoints

↥

Index endpoint: ENTEROPATH_E_COLI – Enteropathogenic Escherichia coli infection

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Enteropathogenic Escherichia coli infection

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints