Enteropathogenic Escherichia coli infection

ENTEROPATH_E_COLI

dysentery: Acute inflammation of the intestine associated with infectious diarrhea of various etiologies, generally acquired by eating contaminated food containing toxins, biological derived from bacteria or other microorganisms. Dysentery is characterized initially by watery feces then by bloody mucoid stools. It is often associated with abdominal pain; fever; and dehydration.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A04.0 Cause of death: ICD-10 — A04.0 2 out of 7 registries used, show all original rules.	103
4. Check minimum number of events None	103
5. Include endpoints None	103
6. Filter based on genotype QC (FinnGen only)	103

Control definitions (FinnGen only)

Control exclude: IBD_BACT_INTEST_INFECTIONS

Extra metadata

First used in FinnGen datafreeze: DF2
Parent code in ICD-10: A04
Name in latin: Infectio ab Escherichia coli enteropathogenica

NAME	ENTEROPATH_E_COLI
CONTROL_EXCLUDE	IBD_BACT_INTEST_INFECTIONS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A040
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A040
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Enteropathogenic Escherichia coli infection based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	847	440	403
Only index persons	730	388	342
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	59.41	61.54	56.93
Only index persons	58.07	59.97	55.91

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	103	50	53
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	62.11	61.95	62.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
90: Matched controls
900

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A04.0

ICD-10 Finland

Enteropathogenic Escherichia coli infection

+∞

129.6

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

7.8

14.6

A49.9

ICD-10 Finland

Bacterial infection, unspecified

7.2

10.3

R50.9

ICD-10 Finland

Fever, unspecified

6.1

9.6

A04.7

ICD-10 Finland

Enterocolitis due to Clostridium difficile

+∞

9.5

TPH04

NOMESCO Finland

Cathetrisation of vein

4.5

8.0

R53

ICD-10 Finland

Malaise and fatigue

4.4

7.5

XF400

NOMESCO Finland

ECG with 12 standard connections

4.6

7.4

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

8.5

6.7

R4110

NOMESCO Finland

Physiotherapy

3.5

6.6

137

A04.5

ICD-10 Finland

Campylobacter enteritis

74.9

6.5

J01MA02

ATC

ciprofloxacin; systemic

3.1

6.3

232

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.4

6.1

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

6.4

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

10.36

27.11

2.0

1.6

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

11.89

19.50

1.3

—

(3000991) Gas panel - Venous blood

4.87

10.18

10.4

10.3

—

(3002032) Base excess in Venous blood by calculation

4.65

10.14

4.9

8.0

2.6

1.7

mmol/l

0.66

(3012544) pH of Venous blood

4.53

9.81

4.9

7.9

—

(3023368) Bacteria identified in Blood by Culture

227

3.47

8.86

7.6

4.2

—

(3025941) Bacteria identified in Stool by Culture

4.86

7.36

1.3

1.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

297

3.06

7.23

5.2

3.5

—

(3013115) Eosinophils [#/volume] in Blood

435

3.18

6.89

11.1

8.0

0.2

e9/l

0.60

385

(3018095) Leukocytes [#/volume] in Urine

303

2.97

6.88

5.5

4.0

19.3

54.0

e6/l

1.18

209

(3026782) Osmolality of Urine

170

3.08

6.69

2.6

2.8

539.0

565.5

mosm/kgh2o

0.28

143

(3006315) Basophils [#/volume] in Blood

423

3.04

6.57

10.6

7.6

0.0

e9/l

0.04

366

(40758558) Short blood count panel - Blood

224

2.90

6.43

18.8

9.1

—

(3002582) Erythrocytes [#/volume] in Urine

264

2.85

6.34

4.7

3.4

11.3

307.1

e6/l

0.62

196

(3014765) Yersinia sp identified in Stool by Organism specific culture

5.07

6.19

1.6

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

5.07

6.19

1.6

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

5.07

6.19

1.6

1.1

—

(3001604) Monocytes [#/volume] in Blood

422

2.92

6.19

10.7

7.5

0.6

e9/l

0.72

365

(3013650) Neutrophils [#/volume] in Blood by Automated count

486

3.00

5.92

21.4

11.7

3.9

4.1

e9/l

0.35

428

(3019198) Lymphocytes [#/volume] in Blood

434

2.79

5.66

10.9

7.5

2.2

1.8

e9/l

0.60

389

(3022096) Basophils/100 leukocytes in Blood

380

2.69

5.60

9.6

8.0

0.6

0.7

0.39

349

(3048689) Calprotectin [Mass/mass] in Stool

117

3.06

5.58

3.2

2.4

329.0

102.3

ug/g

1.44

(3003327) Ova and parasites identified in Stool by Light microscopy

4.61

5.56

2.2

1.3

—

(3030467) Casts [#/volume] in Urine by Automated count

247

2.66

5.50

4.5

3.3

0.3

e6/l

0.05

181

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

100

3.14

5.41

2.8

1.7

—

(36304419) Bacteria [Presence] in Urine

241

2.64

5.40

4.6

3.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

4.90

5.19

1.2

1.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

3.93

5.13

1.8

1.3

—

(3021589) Normoblasts [#/volume] in Blood

397

2.51

4.87

11.3

11.7

0.0

e9/l

0.50

323

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

101

2.95

4.74

2.8

1.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

193

2.54

4.64

6.2

3.7

—

(42870588) Differential panel, method unspecified - Blood

289

2.42

4.60

9.0

8.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

396

2.42

4.54

12.8

8.0

1.2

mmol/l

0.40

339

(3007164) IgA [Mass/volume] in Serum or Plasma

167

2.55

4.42

1.4

1.5

2.3

2.2

g/l

0.10

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.15

4.30

1.5

1.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.70

4.22

2.4

1.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

149

2.55

4.19

4.6

3.1

0.8

1.0

e6/l

0.20

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

136

2.58

4.12

4.8

3.3

1.6

2.9

e6/l

0.45

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

6.93

4.08

1.2

1.8

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

6.93

4.08

1.2

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

145

2.51

3.99

2.9

1.9

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

6.46

3.91

1.1

1.2

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

2.86

3.83

3.3

2.8

0.2

g/l

0.66

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.36

3.69

4.6

6.5

124.1

128.0

g/l

0.25

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

3.48

3.64

4.5

5.7

1.2

1.5

0.39

(3044640) Blood type and Crossmatch panel - Blood

254

2.19

3.57

3.1

2.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

3.40

3.51

1.1

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

199

2.24

3.50

2.6

2.2

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

268

2.12

3.34

6.5

3.2

29.3

34.6

u/l

0.81

253

(3023520) Reticulocytes [#/volume] in Blood

2.84

3.33

3.8

5.5

65.8

66.6

e9/l

—

(3044941) Cell count panel - Synovial fluid

9.00

3.30

1.2

1.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

6.73

3.24

1.4

1.3

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

3.50

3.16

5.6

3.8

23.6

24.3

mmol/l

0.26

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

380

2.04

3.12

4.6

3.9

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

10.41

3.01

1.2

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

10.41

3.01

1.2

1.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.58

2.99

5.3

2.8

—

(3015736) pH of Urine

314

1.99

2.91

6.4

3.7

—

(3021788) Differential panel - Synovial fluid

6.99

2.91

1.7

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.41

2.89

1.9

1.8

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.21

2.78

6.2

2.9

53.3

49.9

0.15

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

328

1.94

2.74

2.0

103.9

91.8

pmol/l

1.12

161

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.66

2.68

7.6

5.5

122.4

80.7

ng/l

0.45

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

189

2.01

2.53

1.5

1.3

1.4

0.9

u/ml

—

(3026008) Bacteria identified in Urine by Culture

256

1.92

2.51

4.3

2.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

166

2.04

2.50

1.8

1.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

113

2.20

2.49

1.5

1.7

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.72

2.47

1.9

1.6

—

(40761535) Cells panel - Urine sediment

2.53

2.45

6.1

3.5

—

(3000093) Morphology [Interpretation] in Blood Narrative

4.83

2.30

1.0

1.2

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.81

2.27

1.1

1.6

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

5.77

2.24

1.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.56

2.22

4.2

2.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

562

1.85

2.15

6.3

4.5

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

3.38

2.14

1.0

1.8

—

(3020891) Body temperature

3.08

2.13

9.7

3.1

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

4.18

2.07

1.0

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

4.18

2.07

1.5

1.4

—

(3003396) Base excess in Arterial blood by calculation

2.14

1.93

13.7

7.4

2.6

1.3

mmol/l

1.08

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.19

1.83

1.3

—

(3003338) MCHC [Mass/volume]

661

1.84

1.83

47.8

20.4

329.6

333.1

g/l

2.96

656

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.45

1.77

17.8

8.2

0.7

0.10

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.47

1.77

1.5

1.8

—

(3019060) Gas panel - Arterial blood

2.34

1.75

4.7

3.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.39

1.70

17.8

8.1

1.2

1.5

0.35

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

3.29

1.68

1.8

7.5

—

4920.0

—

(3037756) Immunofixation for Serum or Plasma

3.12

1.60

1.3

1.5

—

(3014051) Protein [Presence] in Urine by Test strip

3.12

1.60

1.8

1.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

142

1.80

1.55

1.7

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.97

1.53

1.7

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

510

1.61

1.50

3.7

3.0

—

(3018405) Lactate [Moles/volume] in Arterial blood

2.61

1.48

5.0

5.6

1.1

1.4

mmol/l

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

3.23

1.45

1.0

1.4

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.23

1.45

1.8

1.4

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.97

1.45

2.7

1.8

395.3

371.0

nmol/l

0.16

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

162

1.72

1.43

4.8

3.5

302.3

118.0

ng/l

0.27

132

(3000492) Spirometry study

2.09

1.39

1.8

1.6

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.20

1.32

19.5

8.4

89.4

93.5

—

(3024928) Oxygen saturation in Venous blood

2.86

1.30

3.0

10.5

—

(40768797) Stomach Pathology biopsy report

102

1.80

1.26

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.71

1.23

1.0

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

735

1.67

1.22

25.8

13.6

81.6

81.5

ml/min/173m2

0.01

579

(3044889) 12 lead EKG panel

535

1.52

1.21

4.1

4.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

181

1.58

1.13

1.4

2.0

1.5

1.0

mg/l

0.88

140

(3020961) Endomysium IgA Ab [Titer] in Serum

2.03

1.11

1.0

1.1

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.45

1.10

1.0

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

300

1.48

1.08

7.2

3.7

—

(40768804) Tissue Pathology biopsy report

300

1.48

1.08

2.3

2.1

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.98

1.05

18.4

11.7

26.8

24.6

mmol/l

—

(3045414) Leukocytes [Presence] in Urine

2.13

1.05

1.9

1.6

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

2.34

1.04

9.6

3.3

76.4

348.8

mg/l

—

(3034770) Mitochondria Ab [Titer] in Serum

2.34

1.04

1.0

1.2

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

2.34

1.04

9.6

3.3

58.0

27.4

mg/l

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

218

0.59

1.04

2.3

1.6

1.1

1.4

mmol/l

1.76

185

(3042936) Bacteria identified in Isolate by Culture

135

1.60

0.98

2.4

1.8

—

(3001019) Free T4 and TSH panel - Serum or Plasma

2.30

0.95

1.0

1.7

—

(3022145) Colonoscopy Study observation

1.72

0.89

1.9

1.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

157

1.51

0.86

1.7

1.6

1140.9

1193.0

nmol/l

0.11

124

(3000330) Specific gravity of Urine by Test strip

1.80

0.85

3.4

3.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

705

1.44

0.80

36.2

17.5

38.4

39.9

1.44

497

(3036489) Thrombin time

1.87

0.80

2.5

3.6

33.7

21.7

—

(3022621) pH of Urine by Test strip

1.73

0.77

2.2

2.1

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.80

0.73

4.0

3.1

0.0

0.1

e6/l

—

(3032080) INR in Blood by Coagulation assay

339

1.35

0.72

12.1

7.6

1.2

inr

—

104

(3009343) pH of Capillary blood

1.71

0.71

2.4

4.7

—

7.4

—

(1761868) Lipid panel - Serum or Plasma

264

0.70

0.69

4.8

2.8

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.67

0.68

25.6

7.7

—

(36660697) Celiac disease serology panel - Serum

1.68

0.68

1.1

1.2

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

1.82

0.67

1.0

1.5

—

(3000494) Fungus identified in Specimen by Culture

1.53

0.65

1.4

—

(3052851) Hemolysis interference index of Serum or Plasma

1.76

0.64

2.8

3.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.76

0.64

1.0

1.6

—

(3022313) Gas panel - Capillary blood

1.68

0.64

2.6

4.8

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.60

0.0

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.61

0.55

1.7

1.8

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.53

0.52

1.7

2.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

812

1.36

0.49

38.3

15.1

34.1

23.2

mg/l

1.75

648

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.43

0.46

1.3

1.6

—

(21494755) Public health laboratory ask at order entry panel

1.49

0.44

1.3

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.41

0.42

1.3

1.6

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

3.1

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

734

1.26

0.40

5.4

4.8

1.8

1.9

mu/l

0.82

664

(3019832) Treponema pallidum Ab [Presence] in Serum

1.37

0.40

1.3

1.7

—

(40768793) Breast Pathology biopsy report

0.00

0.39

0.0

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

163

1.28

0.38

1.7

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

772

0.81

0.37

4.6

4.4

1.4

1.5

mmol/l

0.52

713

(4010399)

1.39

0.34

1.4

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.34

0.33

1.6

2.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

102

1.31

0.32

2.0

2.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.27

0.30

1.6

2.2

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.31

0.29

1.8

2.1

1.3

1.6

0.86

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

307

1.16

0.24

5.2

3.6

38.9

38.5

ng/l

0.01

224

(3013512) EKG study

240

0.84

0.23

3.4

4.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

212

1.17

0.22

4.8

3.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.20

0.22

1.2

2.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.6

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.21

0.0

1.5

—

5.7

—

(4146454)

0.00

0.21

0.0

3.9

—

(4268621)

0.00

0.21

0.0

1.9

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.21

0.0

1.2

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.1

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.7

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.0

—

(4306422)

0.00

0.21

0.0

1.2

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.21

0.0

3.1

—

62.8

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

1.2

—

1.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.2

—

137.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

175

1.18

0.20

7.8

5.2

—

(3022217) INR in Platelet poor plasma by Coagulation assay

100

1.23

0.19

32.5

28.2

—

1.6

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

747

0.88

0.19

4.3

4.0

1.3

mmol/l

0.03

689

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

792

0.89

0.15

5.3

5.0

2.6

mmol/l

0.13

729

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.14

0.10

3.8

2.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.12

0.10

1.2

1.0

—

(3017732) Neutrophils [#/volume] in Blood

0.82

0.08

3.8

2.2

3.8

3.9

e9/l

—

(40761511) CBC panel - Blood by Automated count

836

1.10

0.08

25.8

13.8

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.84

0.07

2.3

1.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.84

0.07

7.0

3.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

161

0.92

0.05

1.9

3.0

0.6

0.7

ug/l

—

111

(3009508) Creatinine [Moles/volume] in Urine

258

1.06

0.05

5.4

3.5

8.0

7.8

mmol/l

0.09

212

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

222

1.05

0.02

3.2

4.3

20.0

21.3

—

112

(3002256) Pathology report gross observation

1.08

0.02

1.2

—

(3003694) ABO and Rh group [Type] in Blood

235

1.03

0.00

1.3

1.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

764

0.98

0.00

4.7

4.4

6.1

5.9

mmol/l

0.75

696

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.01

0.00

29.4

7.7

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.94

0.00

2.2

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(4027681)

0.00

0.0

1.2

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.4

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.2

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

1.7

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.4

—

91.8

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

11.8

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

3.2

—

110.8

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

2.1

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.3

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.7

—

38.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

27.7

—

(4035726)

0.93

0.00

1.1

1.4

—

(4281824)

0.00

0.0

1.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.91

0.00

1.4

1.3

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

4.0

—

33.6

—

(3017704) Immunofixation for Urine

0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

3.1

—

79.7

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

12.8

—

(4062490)

0.00

0.0

1.3

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

1.7

—

17.6

—

(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

(4211845)

0.00

0.0

1.4

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.3

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3010503) CD19 cells [#/volume] in Blood

0.00

0.0

1.2

—

0.1

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

2.1

—

13.7

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

4.8

—

(3012565) Volume of 24 hour Urine

0.00

0.0

2.2

—

2208.3

—

(4024509)

0.00

0.0

1.0

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint ENTEROPATH_E_COLI and mortality.

Females

Parameter	HR [95% CI]	p-value
ENTEROPATH_E_COLI	2.339 [1.61, 3.41]	< 0.001
Birth year	1.0 [0.99, 1.01]	0.938

During the follow-up period (1.1.1998 — 31.12.2019), 122 out of 367 females with ENTEROPATH_E_COLI died.

Males

Parameter	HR [95% CI]	p-value
ENTEROPATH_E_COLI	2.601 [1.56, 4.34]	< 0.001
Birth year	0.982 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 334 males with ENTEROPATH_E_COLI died.

Mortality risk

Mortality risk for people of age

years, who have ENTEROPATH_E_COLI.

N-year risk	Females	Males
1	0.256%	0.401%
5	1.533%	2.463%
10	3.763%	6.297%
15	7.396%	12.017%
20	12.958%	19.635%

Relationships between endpoints

↥

Index endpoint: ENTEROPATH_E_COLI – Enteropathogenic Escherichia coli infection

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Enteropathogenic Escherichia coli infection

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints