macular degeneration: Loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. [ NCIT:P378 ]
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
174 |
4. Check minimum number of eventsNone |
174 |
5. Include endpointsNone |
174 |
6. Filter based on genotype QC (FinnGen only) |
169 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other proliferative retinopathy
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1077 | 486 | 586 |
| Only index persons | 954 | 436 | 518 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 57.82 | 60.71 | 55.52 |
| Only index persons | 57.13 | 59.71 | 54.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 169 | 77 | 92 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 53.44 | 51.30 | 55.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 174
- Matched controls
- 1740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.29
ICD-10 Finland
Other proliferative retinopathy
+∞
110.5
94
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
61.2
107.6
63
16
A10AB01
ATC
insulin (human); parenteral
80.6
107.3
59
11
A10AA02, ,
ATC
64.7
99.4
57
13
A10AC01
ATC
insulin (human); parenteral
26.1
96.1
80
55
T89
ICPC
Diabetes insulin dependent
51.1
92.3
56
16
A10AA01, ,
ATC
65.2
89.6
51
11
XCK10
NOMESCO Finland
Photography of fundus of eye
21.1
83.7
77
63
XCW99
NOMESCO Finland
Other investigative procedure of eye
21.6
83.3
75
59
A10AB05
ATC
insulin aspart; parenteral
21.2
80.2
72
56
H35.20
ICD-10 Finland
Proliferative vitreoretinopathy
+∞
74.4
66
*
A10AE04
ATC
insulin glargine; parenteral
17.1
74.2
78
79
CKC12
NOMESCO Finland
Photocoagulation of retina
540.9
72.3
67
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
514.3
69.9
65
*
A10AB04
ATC
insulin lispro; parenteral
38.9
68.2
44
15
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
17.2
62.9
61
53
H43.1
ICD-10 Finland
Vitreous haemorrhage
151.0
59.3
60
6
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
58.7
53
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
22.6
58.7
47
28
A10AE05
ATC
insulin detemir; parenteral
21.1
56.8
47
30
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
204.6
56.7
56
*
H3603, E103,
ICD-10 Finland
+∞
51.7
47
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
88.4
50.9
55
9
103
Kela drug reimbursment
Diabetes, insulin-treated
9.1
48.9
107
259
XCH00
NOMESCO Finland
Eye pressure measurement
21.6
48.6
39
23
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
14.7
43.1
43
38
215
Kela drug reimbursment
Diabetes, non-insulin-treated
7.7
40.9
91
217
H36.01
ICD-10 Finland
Diabetic maculopathy
+∞
40.2
37
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
80.8
39.3
43
7
Z01.0
ICD-10 Finland
Examination of eyes and vision
7.4
36.3
73
155
H36.00
ICD-10 Finland
Diabetic background retinopathy
+∞
29.0
27
*
H3603, E113,
ICD-10 Finland
+∞
29.0
27
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
43.3
28.7
35
10
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
172.7
28.6
29
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
27.9
26
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
165.7
27.5
28
*
H04AA01
ATC
glucagon; nasal, parenteral
71.9
27.0
30
5
S01ED51
ATC
timolol, combinations; ophthalmic
9.2
26.5
36
48
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
25.7
24
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.9
25.4
47
89
CKC15
NOMESCO Finland
Panretinal photocoagulation
+∞
24.6
23
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
24.6
23
*
C02AC05
ATC
moxonidine; oral
11.2
23.8
27
28
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
263.2
23.2
23
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
263.2
23.2
23
*
XCD20
NOMESCO Finland
Photoangiography of eye
263.2
23.2
23
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.6
22.5
95
360
A10AD01
ATC
insulin (human); parenteral
39.6
21.9
27
8
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.5
21.4
84
299
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
237.2
21.1
21
*
XCK00
NOMESCO Finland
Perimetry
8.5
20.6
29
40
H3601, E103,
ICD-10 Finland
+∞
20.2
19
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
39.4
19.5
24
7
WX140
NOMESCO Finland
Parabulbar anesthesy
27.5
19.3
26
11
SPAT1262
SPAT
Handing over of treatment supplies
4.9
19.2
53
142
A10AE06
ATC
insulin degludec; parenteral
25.2
18.8
26
12
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
199.5
17.9
18
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
56.1
17.4
20
*
H26.4
ICD-10 Finland
After-cataract
6.8
17.3
30
52
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
70.6
17.1
19
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
39.5
17.1
21
6
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
16.9
16
*
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
16.9
16
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
+∞
15.9
15
*
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
23.6
15.1
21
10
Z94.0
ICD-10 Finland
Kidney transplant status
87.7
14.8
16
*
L04AD02
ATC
tacrolimus; systemic
+∞
14.8
14
*
H3601, E113,
ICD-10 Finland
+∞
14.8
14
*
C03CA01
ATC
furosemide; systemic
3.5
14.6
77
321
CJB10
NOMESCO Finland
Laser discission of secondary cataract
6.2
14.5
27
50
ZXA05
NOMESCO Finland
Left side
3.6
14.3
65
245
A11CC03
ATC
alfacalcidol; systemic
26.4
14.1
19
8
T90
ICPC
Diabetes non-insulin dependent
3.7
13.8
58
207
137
Kela drug reimbursment
Uraemia requiring dialysis
81.3
13.8
15
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
81.3
13.8
15
*
127
Kela drug reimbursment
Transplant complication
37.4
13.8
17
5
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
+∞
13.7
13
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
+∞
13.7
13
*
H3600, E103,
ICD-10 Finland
+∞
13.7
13
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
13.7
13
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
23.5
13.7
19
9
H34.8
ICD-10 Finland
Other retinal vascular occlusions
151.3
13.7
14
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
151.3
13.7
14
*
C10AA01
ATC
simvastatin; oral
3.3
13.4
94
460
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
24.9
13.2
18
8
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.3
12.8
23
41
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
75.5
12.8
14
*
C09AA02
ATC
enalapril; systemic
3.7
12.8
52
181
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
+∞
12.7
12
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
12.7
12
*
205
Kela drug reimbursment
Chronic hypertension
3.3
12.5
64
258
A10AA03, ,
ATC
40.7
12.4
15
*
C10AA07
ATC
rosuvastatin; oral
3.2
12.3
71
307
S01EA05
ATC
brimonidine; ophthalmic
16.2
12.1
19
13
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
+∞
11.6
11
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
+∞
11.6
11
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
+∞
11.6
11
*
H25.1
ICD-10 Finland
Senile nuclear cataract
3.2
11.5
61
249
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
11.2
11.4
21
21
L04AA06
ATC
mycophenolic acid; systemic
21.9
11.4
16
8
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
6.3
11.3
20
35
J01FF01
ATC
clindamycin; systemic
3.1
11.0
64
275
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.2
10.9
57
230
B05DA
ATC
Isotonic solutions
64.0
10.8
12
*
B05DB
ATC
Hypertonic solutions
116.8
10.5
11
*
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
10.5
10
*
H36.02
ICD-10 Finland
Preproliferative diabetic retinopathy
+∞
10.5
10
*
H3603, E106,
ICD-10 Finland
+∞
10.5
10
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
34.9
10.5
13
*
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
25.2
10.4
14
6
ZXA10
NOMESCO Finland
Bilateral
3.3
10.2
48
181
C10AX09
ATC
ezetimibe; oral
3.4
10.1
43
152
S01EC01
ATC
acetazolamide; systemic
10.5
10.1
19
20
A12AA04
ATC
calcium carbonate; oral
21.6
10.0
14
7
S01EE01
ATC
latanoprost; ophthalmic
5.3
9.8
21
44
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
58.3
9.8
11
*
C10AA05
ATC
atorvastatin; oral
2.7
9.6
85
452
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.7
9.5
88
477
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
105.5
9.5
10
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
23.2
9.5
13
6
H3600, E113,
ICD-10 Finland
+∞
9.5
9
*
N18.8
ICD-10 Finland
Other chronic renal failure
14.8
9.4
15
11
C08CA01
ATC
amlodipine; oral
2.7
9.4
81
424
H26.2
ICD-10 Finland
Complicated cataract
38.9
9.1
11
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.6
9.1
34
110
TK800
NOMESCO Finland
Hemodialysis
13.5
9.1
15
12
ZXD10
NOMESCO Finland
Scheduled procedure
2.6
8.8
78
411
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
52.7
8.8
10
*
A10AD05
ATC
insulin aspart; parenteral
17.4
8.7
13
8
NHQ40
NOMESCO Finland
Amputation of toe
21.3
8.6
12
6
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
21.3
8.6
12
6
N18.0
ICD-10 Finland
End-stage renal disease
29.2
8.6
11
*
177
Kela drug reimbursment
Insulin glargine 300 U / ml
13.7
8.5
14
11
Z49.2
ICD-10 Finland
Other dialysis
94.4
8.5
9
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
94.4
8.5
9
*
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
94.4
8.5
9
*
CKD50
NOMESCO Finland
Endodiathermy of retina
+∞
8.4
8
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
8.4
8
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
8.4
8
*
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
8.4
8
*
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
8.4
8
*
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
+∞
8.4
8
*
H3603, E107,
ICD-10 Finland
+∞
8.4
8
*
C09AA05
ATC
ramipril; oral
2.8
8.4
56
255
I10
ICD-10 Finland
Essential (primary) hypertension
2.6
8.3
115
741
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.8
8.2
55
250
V03AE01
ATC
polystyrene sulfonate; oral
23.3
8.1
11
5
114
Kela drug reimbursment
Glaucoma
4.1
8.1
24
66
C08CA02
ATC
felodipine; oral
3.9
8.0
25
71
C08CA13
ATC
lercanidipine; oral
3.3
8.0
34
119
S01ED01
ATC
timolol; ophthalmic
7.3
7.8
18
27
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
19.4
7.7
11
6
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
26.3
7.7
10
*
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
26.3
7.7
10
*
C07AB02
ATC
metoprolol; systemic
2.8
7.6
45
191
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
83.5
7.5
8
*
V03AE02
ATC
sevelamer; oral
83.5
7.5
8
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.8
7.4
17
38
RJ120, ,
NOMESCO Finland
+∞
7.3
7
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
7.3
7
*
JLE03
NOMESCO Finland
Allogenic total transplantation of pancreas with pancreaticoenterostomy
+∞
7.3
7
*
H3601, E106,
ICD-10 Finland
+∞
7.3
7
*
H3603, E108,
ICD-10 Finland
+∞
7.3
7
*
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
+∞
7.3
7
*
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
+∞
7.3
7
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
31.4
7.2
9
*
S01EA03
ATC
apraclonidine; ophthalmic
31.4
7.2
9
*
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
4.2
7.2
20
52
H26.02
ICD-10 Finland
Presenil cataract
9.4
7.2
14
16
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
7.5
7.2
16
23
B01AC04
ATC
clopidogrel; oral
2.9
7.2
40
164
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
7.2
56
273
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
7.1
62
319
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
6.9
37
148
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.5
6.9
26
84
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
17.6
6.8
10
6
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
17.6
6.8
10
6
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.9
6.8
16
25
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
41.7
6.8
8
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
41.7
6.8
8
*
C07AB07
ATC
bisoprolol; oral
2.3
6.8
94
587
Z3231
NOMESCO Finland
Registered nurse
2.4
6.8
61
316
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
23.6
6.7
9
*
S97
ICPC
Chronic ulcer skin
4.5
6.7
17
41
S01EX03, ,
ATC
12.9
6.7
11
9
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
6.6
69
382
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.2
6.6
28
98
H40.0
ICD-10 Finland
Glaucoma suspect
4.1
6.6
19
51
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
7.9
6.6
14
19
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.6
6.5
47
219
H25.8
ICD-10 Finland
Other senile cataract
3.4
6.5
25
82
V03AE03
ATC
lanthanum carbonate; oral
72.4
6.5
7
*
ZXA00
NOMESCO Finland
Right side
2.5
6.5
54
270
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
18.9
6.3
9
5
R21
NOMESCO Finland
Counselling and guidance in rehabilitation
27.8
6.3
8
*
XCW10
NOMESCO Finland
Assessment of vision
27.8
6.3
8
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
+∞
6.3
6
*
H3601, H3520,
ICD-10 Finland
+∞
6.3
6
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
6.3
6
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
+∞
6.3
6
*
TK820
NOMESCO Finland
Peritoneal dialysis
+∞
6.3
6
*
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
+∞
6.3
6
*
H3601, E116,
ICD-10 Finland
+∞
6.3
6
*
BEF00, ,
SPAT
+∞
6.3
6
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.6
6.2
22
68
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.5
6.2
49
238
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
10.6
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
86
352
3.85
17.27
8.2
3.7
40.58
9.71
mg/mmol
2.64
72
229
48
150
4.04
13.87
6.5
2.0
23.77
21.17
%
0.64
43
125
43
159
3.26
9.38
24.1
5.1
1.24
1.02
mmol/l
3.02
43
147
18
22
8.99
8.83
3.3
1.9
346.40
158.30
ug/min
—
12
10
117
773
2.57
7.85
11.5
4.6
9.07
6.60
mmol/l
9.79
112
712
99
609
2.45
7.72
21.8
6.2
1.21
1.21
mmol/l
0.14
92
529
26
79
3.69
7.60
3.5
2.9
1.64
1.78
mmol/l
0.06
17
55
23
68
3.75
6.97
7.5
7.4
23.27
24.54
mmol/l
0.99
23
68
37
148
2.91
6.93
8.6
8.0
0.49
1.13
mmol/l
0.45
27
113
6
0
+∞
6.28
6.3
0.0
—
—
—
0
0
77
454
2.25
6.27
6.9
3.0
—
—
—
0
0
60
336
2.20
5.40
3.4
3.3
2650.33
1315.82
ng/l
1.33
53
287
80
504
2.09
5.29
3.3
2.2
70.59
75.12
nmol/l
0.66
75
453
19
60
3.43
5.22
1.3
2.5
1.66
1.48
g/l
0.43
19
52
89
588
2.05
5.13
17.9
11.7
1.27
1.22
inr
0.16
29
173
46
237
2.28
5.02
5.7
3.0
481.05
181.90
ng/l
0.34
37
172
13
24
5.76
5.02
2.3
1.1
—
—
—
0
0
43
217
2.30
4.92
2.4
1.8
—
—
—
0
0
15
42
3.81
4.88
1.3
1.1
—
—
—
0
0
52
285
2.18
4.88
1.5
1.2
3.89
2.31
u/ml
0.28
15
77
43
219
2.28
4.81
4.5
2.5
1.64
1.46
e6/l
0.08
25
110
63
375
2.07
4.75
5.4
2.9
0.39
0.37
e6/l
0.03
45
272
12
22
5.78
4.69
1.6
1.1
—
—
—
0
0
32
146
2.46
4.56
2.0
1.5
—
—
—
0
0
82
545
1.95
4.48
13.0
4.2
34.30
36.17
g/l
2.44
77
516
32
150
2.39
4.30
2.1
1.6
—
—
—
0
0
44
239
2.13
4.16
3.8
2.4
0.73
0.78
e6/l
0.05
26
128
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
13
32
4.30
3.99
3.3
2.5
0.29
0.29
u/ml
—
6
16
81
559
1.84
3.77
5.5
2.5
153.45
112.21
ug/l
1.09
75
510
27
128
2.31
3.53
3.6
3.0
—
—
—
0
0
13
43
3.19
3.33
1.3
3.0
—
—
—
0
0
47
285
1.89
3.21
1.6
1.8
1.12
1.21
mg/l
0.09
35
220
64
429
1.78
3.17
4.7
3.0
2.30
2.35
mmol/l
2.22
64
386
20
87
2.47
3.14
1.7
1.4
—
—
—
0
0
103
794
1.73
3.07
10.1
9.0
4.11
4.11
e9/l
0.01
92
703
11
31
3.72
3.05
1.1
1.9
—
—
—
0
0
71
496
1.73
3.02
2.1
1.8
96.61
91.63
pmol/l
0.55
38
256
39
229
1.91
2.92
1.6
1.6
1361.16
1167.13
nmol/l
0.33
30
177
30
166
1.98
2.66
9.7
7.9
104.17
104.17
mmol/l
0.00
30
166
18
82
2.33
2.58
1.4
1.5
—
—
—
0
0
5
7
7.31
2.56
1.6
1.1
—
—
—
0
0
117
972
1.62
2.30
4.6
3.6
14.79
14.69
pmol/l
0.16
112
896
85
656
1.58
2.29
5.4
3.4
0.00
0.00
estimate
-0.00
14
133
70
517
1.59
2.27
4.9
4.0
977.62
54.03
ng/l
0.62
57
351
11
41
2.79
2.25
1.1
2.0
104.00
86.56
%
2.00
11
41
85
663
1.55
2.14
5.5
3.5
0.00
0.00
estimate
-0.00
11
120
5
10
5.11
2.08
1.0
1.0
—
—
—
0
0
6
15
4.10
2.05
4.0
3.7
—
—
—
0
0
8
26
3.17
2.04
3.0
2.4
112.50
127.69
g/l
—
8
16
9
32
2.91
2.03
2.0
1.7
—
—
—
0
0
12
51
2.45
2.00
2.5
2.0
—
—
—
0
0
5
142
0.33
1.99
1.8
1.8
—
—
—
0
0
83
653
1.52
1.97
7.3
4.6
0.00
0.00
estimate
-0.00
13
128
76
597
1.48
1.77
3.6
2.5
—
—
—
0
0
19
105
1.91
1.71
4.9
2.4
57.09
65.19
ml/min/173m2
0.37
11
47
8
31
2.65
1.68
2.4
1.4
—
—
—
0
0
12
56
2.23
1.65
3.3
2.1
—
—
—
0
0
45
321
1.54
1.63
2.2
1.6
1.57
1.39
mmol/l
0.46
40
273
142
1277
1.61
1.63
30.0
12.3
71.71
84.15
ml/min/173m2
5.34
126
1030
37
253
1.59
1.61
2.1
1.7
444.90
432.97
pmol/l
0.13
30
220
6
20
3.07
1.59
1.5
1.2
—
—
—
0
0
6
22
2.79
1.44
2.2
1.8
—
—
—
0
0
6
22
2.79
1.44
2.2
1.8
—
—
—
0
0
9
40
2.32
1.42
1.3
2.4
266.00
177.95
%
—
9
40
115
1003
1.43
1.42
5.9
3.8
19.39
12.05
mm/h
2.98
110
914
131
1171
1.48
1.41
34.9
16.1
14.64
14.94
%
0.26
126
1155
0
39
0.00
1.35
0.0
1.4
—
—
—
0
0
0
39
0.00
1.35
0.0
1.4
—
—
—
0
0
0
39
0.00
1.35
0.0
1.4
—
—
—
0
0
0
41
0.00
1.33
0.0
1.6
—
—
—
0
0
6
25
2.45
1.25
1.2
1.3
—
—
—
0
0
15
87
1.79
1.19
3.1
2.0
456.33
243.33
ng/l
0.32
15
76
13
72
1.87
1.18
2.0
3.3
3.99
4.47
pmol/l
1.02
13
61
5
20
2.54
1.16
1.6
1.4
—
—
—
0
0
7
30
2.39
1.13
2.0
1.7
—
—
—
0
0
41
310
1.42
1.11
3.9
2.2
—
—
—
0
0
5
22
2.31
1.04
1.6
1.7
—
—
—
0
0
29
208
1.47
1.03
1.1
1.2
1.28
8.28
u/ml
2.37
12
87
13
76
1.77
1.02
2.2
1.5
—
—
—
0
0
9
50
1.84
0.98
3.6
1.8
—
—
—
0
0
7
37
1.93
0.95
2.7
2.2
—
—
—
0
0
6
29
2.11
0.90
1.3
1.4
—
—
—
0
0
6
29
2.11
0.90
1.3
1.4
—
—
—
0
0
45
361
1.33
0.85
5.9
3.6
0.00
0.00
estimate
-0.00
12
120
11
173
0.61
0.80
1.5
2.0
—
—
—
0
0
13
196
0.64
0.79
1.6
2.2
—
—
—
0
0
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
5
25
2.03
0.73
1.8
1.7
—
—
—
0
0
60
511
1.27
0.73
5.6
3.5
—
—
—
0
0
146
1382
1.35
0.72
33.4
13.3
19.25
22.64
mg/l
0.83
125
1071
19
259
0.70
0.72
1.4
1.6
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
8.09
—
0
17
11
155
0.69
0.51
3.4
4.3
33.27
30.96
%
0.38
11
104
33
387
0.82
0.43
4.1
3.8
28.16
22.13
%
0.76
15
177
5
32
1.58
0.42
1.4
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
43
488
0.84
0.40
4.8
4.2
2.93
2.32
ug/l
0.18
43
442
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
9
66
1.38
0.39
1.0
1.0
—
—
—
0
0
23
276
0.81
0.38
2.6
2.7
1.13
0.79
ug/l
0.78
15
172
6
41
1.48
0.36
1.2
1.0
—
17.06
—
0
5
25
211
1.22
0.34
1.3
1.3
12.12
33.57
iu/ml
—
5
74
149
1529
0.82
0.34
44.7
19.3
39.03
40.76
%
3.00
149
1449
6
47
1.29
0.32
1.8
3.0
—
—
—
0
0
99
940
1.12
0.29
3.2
3.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
7.46
—
0
10
0
13
0.00
0.21
0.0
1.2
—
100.62
—
0
13
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
2.4
—
13.15
—
0
14
17
156
1.10
0.08
7.0
8.0
—
—
—
0
0
18
166
1.09
0.08
1.5
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
9.38
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
74
0.94
-0.00
1.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
65
0.92
-0.00
1.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.1
—
110.29
—
0
7
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_PROLIFRETINOPATHOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PROLIFRETINOPATHOTH | 1.757 [1.36, 2.28] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.222 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 421 females with H7_PROLIFRETINOPATHOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PROLIFRETINOPATHOTH | 1.773 [1.38, 2.27] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 508 males with H7_PROLIFRETINOPATHOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_PROLIFRETINOPATHOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.26% |
| 5 | 0.924% | 1.798% |
| 10 | 2.162% | 4.647% |
| 15 | 4.478% | 9.113% |
| 20 | 8.041% | 15.572% |
Relationships between endpoints
↥Index endpoint: H7_PROLIFRETINOPATHOTH – Other proliferative retinopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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