macular degeneration: Loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
151 |
4. Check minimum number of eventsNone |
151 |
5. Include endpointsNone |
151 |
6. Filter based on genotype QC (FinnGen only) |
151 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other proliferative retinopathy
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1077 | 486 | 586 |
| Only index persons | 954 | 436 | 518 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 57.82 | 60.71 | 55.52 |
| Only index persons | 57.13 | 59.71 | 54.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 151 | 71 | 80 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 52.23 | 51.52 | 52.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 144
- Matched controls
- 1439
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.29
ICD-10 Finland
Other proliferative retinopathy
+∞
100.0
84
*
H35.20
ICD-10 Finland
Proliferative vitreoretinopathy
+∞
67.0
59
*
CKC12
NOMESCO Finland
Photocoagulation of retina
819.3
57.9
53
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
268.2
54.0
52
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
+∞
48.8
44
*
H3603, E103
ICD-10 Finland
NA
+∞
48.8
44
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
30.2
47.8
66
39
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
47.6
43
*
XCK10
NOMESCO Finland
Photography of fundus of eye
26.8
46.5
67
45
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
84.0
46.1
50
9
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
167.0
45.9
46
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
111.3
44.0
46
6
A10AA02
ATC
NA
64.5
42.4
48
11
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
56.2
42.2
49
13
A10AA01
ATC
NA
117.2
40.3
42
5
XCW99
NOMESCO Finland
Other investigative procedure of eye
20.5
39.4
62
51
A10AE04
ATC
insulin glargine; parenteral
18.4
37.1
61
55
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
22.1
36.4
55
39
T89
ICPC
Diabetes insulin dependent
48.6
35.2
42
12
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
59.1
31.4
36
8
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
105.9
31.3
33
*
H36.01
ICD-10 Finland
Diabetic maculopathy
+∞
30.3
28
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
360.7
30.0
29
*
103
Kela drug reimbursment
Diabetes, insulin-treated
7.7
27.4
83
215
H3603, E113
ICD-10 Finland
NA
+∞
26.9
25
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
22.8
26.8
39
23
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
62.5
26.4
30
6
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
+∞
25.8
24
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
24.7
23
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
20.4
23.9
36
23
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
23.6
22
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
23.6
22
*
H04AA01
ATC
glucagon; nasal, parenteral
74.9
22.7
25
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
+∞
22.5
21
*
A10AE05
ATC
insulin detemir; parenteral
14.3
21.9
38
35
Z01.0
ICD-10 Finland
Examination of eyes and vision
8.3
21.8
54
97
XCD20
NOMESCO Finland
Photoangiography of eye
+∞
21.4
20
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
+∞
21.4
20
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
+∞
21.4
20
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
16.1
20.7
34
27
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
+∞
20.3
19
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
6.2
20.2
67
178
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
5.3
19.5
85
308
H3601, E103
ICD-10 Finland
NA
+∞
19.2
18
*
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
42.8
18.2
22
6
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
72.3
17.2
19
*
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
17.0
16
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
102.2
17.0
18
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
178.6
15.8
16
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.6
15.5
68
233
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.7
14.9
41
81
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
+∞
14.8
14
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
14.8
14
*
XCH00
NOMESCO Finland
Eye pressure measurement
18.3
14.5
22
14
S01ED51
ATC
timolol, combinations; ophthalmic
9.0
13.9
30
41
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
82.9
13.9
15
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
13.8
13
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
+∞
13.8
13
*
WX140
NOMESCO Finland
Parabulbar anesthesy
24.0
13.7
19
9
A10AE06
ATC
insulin degludec; parenteral
31.8
13.3
17
6
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
25.5
13.3
18
8
SPAT1262
SPAT
Handing over of treatment supplies
4.9
12.9
48
134
C03CA01
ATC
furosemide; systemic
4.0
12.7
64
239
H3601, E113
ICD-10 Finland
NA
+∞
12.7
12
*
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
+∞
12.7
12
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
12.7
12
*
H3600, E103
ICD-10 Finland
NA
+∞
12.7
12
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
+∞
12.7
12
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
+∞
12.7
12
*
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
29.7
12.3
16
6
ZXA05
NOMESCO Finland
Left side
4.1
12.1
57
199
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
18.5
12.0
18
11
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
16.9
11.7
18
12
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
+∞
11.6
11
*
S01EC01
ATC
acetazolamide; systemic
19.1
11.5
17
10
C10AA01
ATC
simvastatin; oral
3.4
11.2
79
376
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
17.8
10.6
16
10
XCK00
NOMESCO Finland
Perimetry
7.5
10.6
25
39
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
118.3
10.6
11
*
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
118.3
10.6
11
*
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
10.5
10
*
ZXA10
NOMESCO Finland
Bilateral
4.5
10.5
41
118
137
Kela drug reimbursment
Uraemia requiring dialysis
43.3
10.1
12
*
A10AA03
ATC
NA
43.3
10.1
12
*
Z94.0
ICD-10 Finland
Kidney transplant status
43.3
10.1
12
*
C02AC05
ATC
moxonidine; oral
9.1
9.7
20
25
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
106.8
9.5
10
*
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
+∞
9.5
9
*
C09AA02
ATC
enalapril; systemic
3.7
9.3
45
156
J01FF01
ATC
clindamycin; systemic
3.3
9.2
56
232
E10
ICD-10 Finland
Type 1 diabetes mellitus
39.4
9.2
11
*
C10AA07
ATC
rosuvastatin; oral
3.5
8.9
50
192
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
9.2
8.9
18
22
177
Kela drug reimbursment
Insulin glargine 300 U / ml
21.6
8.6
12
6
C10AA05
ATC
atorvastatin; oral
3.0
8.5
64
303
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.9
8.5
71
358
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
95.4
8.5
9
*
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
95.4
8.5
9
*
205
Kela drug reimbursment
Chronic hypertension
3.2
8.4
54
229
H3600, E113
ICD-10 Finland
NA
+∞
8.4
8
*
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
+∞
8.4
8
*
CKD50
NOMESCO Finland
Endodiathermy of retina
+∞
8.4
8
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
8.4
8
*
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
8.4
8
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
8.4
8
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
+∞
8.4
8
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
+∞
8.4
8
*
127
Kela drug reimbursment
Transplant complication
15.7
8.4
13
9
A11CC03
ATC
alfacalcidol; systemic
12.8
7.7
13
11
S01ED01
ATC
timolol; ophthalmic
7.9
7.7
17
24
S01EX03
ATC
NA
19.7
7.7
11
6
N18.8
ICD-10 Finland
Other chronic renal failure
10.9
7.7
14
14
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.9
7.7
25
59
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
26.6
7.7
10
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
84.2
7.5
8
*
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
84.2
7.5
8
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.2
7.5
44
174
114
Kela drug reimbursment
Glaucoma
5.3
7.4
22
47
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
16.9
7.4
11
7
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
7.3
7
*
H25.1
ICD-10 Finland
Senile nuclear cataract
3.0
7.3
48
203
S01EA03
ATC
apraclonidine; ophthalmic
31.8
7.2
9
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
31.8
7.2
9
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
31.8
7.2
9
*
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
31.8
7.2
9
*
L04AA06
ATC
mycophenolic acid; systemic
13.0
7.2
12
10
ZXD10
NOMESCO Finland
Scheduled procedure
2.7
7.2
65
337
S01EE01
ATC
latanoprost; ophthalmic
7.0
7.2
17
27
A12AA04
ATC
calcium carbonate; oral
14.7
7.0
11
8
H26.02
ICD-10 Finland
Presenil cataract
10.1
6.9
13
14
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.9
6.9
22
51
T90
ICPC
Diabetes non-insulin dependent
3.1
6.9
41
162
B01AC04
ATC
clopidogrel; oral
3.7
6.9
31
100
B05DA
ATC
Isotonic solutions
42.1
6.8
8
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
23.8
6.8
9
*
ZXA00
NOMESCO Finland
Right side
2.8
6.6
50
229
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
8.0
6.6
14
19
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.7
6.6
18
35
S01FA04
ATC
cyclopentolate; ophthalmic
15.2
6.5
10
7
NHQ40
NOMESCO Finland
Amputation of toe
15.2
6.5
10
7
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
72.9
6.5
7
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
72.9
6.5
7
*
I10
ICD-10 Finland
Essential (primary) hypertension
2.5
6.3
89
572
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
+∞
6.3
6
*
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
6.3
6
*
RJ120
NOMESCO Finland
NA
+∞
6.3
6
*
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
+∞
6.3
6
*
H3603, E107
ICD-10 Finland
NA
+∞
6.3
6
*
C09AA05
ATC
ramipril; oral
2.8
6.2
46
209
TK800
NOMESCO Finland
Hemodialysis
9.2
6.2
12
14
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
13.3
6.2
10
8
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
6.0
29
99
Mortality – FinRegistry
↥Association
Association between endpoint H7_PROLIFRETINOPATHOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PROLIFRETINOPATHOTH | 1.757 [1.36, 2.28] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.222 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 421 females with H7_PROLIFRETINOPATHOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PROLIFRETINOPATHOTH | 1.773 [1.38, 2.27] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 508 males with H7_PROLIFRETINOPATHOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_PROLIFRETINOPATHOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.26% |
| 5 | 0.924% | 1.798% |
| 10 | 2.162% | 4.647% |
| 15 | 4.478% | 9.113% |
| 20 | 8.041% | 15.572% |
Relationships between endpoints
↥Index endpoint: H7_PROLIFRETINOPATHOTH – Other proliferative retinopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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