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This is a non-core endpoint: only basic statistics are computed.

Ankylosis of teeth

EFO Endpoint Browser

K11_ANKYLOSIS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K03.5
  • Hospital discharge: ICD-9 — 5216
  • Hospital discharge: ICD-8 — 5216
  • Cause of death: ICD-10 — K03.5
  • Cause of death: ICD-9 — 5216
  • Cause of death: ICD-8 — 5216

2 out of 7 registries used, show all original rules.

52

4. Check minimum number of events

None

52

5. Include endpoints

None

52

6. Filter based on genotype QC (FinnGen only)

52

Control definitions (FinnGen only)

Control exclude
K11_ORAL

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 605 292 312
Only index persons 564 273 291
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 15.72 14.94 16.27
Only index persons 15.85 15.28 16.38

-FinnGen-

Key figures

All Female Male
Number of individuals 52 34 18
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 25.50 23.70 28.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
51
Matched controls
511
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K03.5
ICD-10 Finland
Ankylosis of teeth
+∞
61.5
46
*
EBA10
NOMESCO Finland
Surgical removal of tooth
34.7
21.2
28
17
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
153.2
12.0
12
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
+∞
9.7
9
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
24.2
9.5
13
7
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
18.7
9.4
14
10
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
25.5
9.0
12
6
K05.32
ICD-10 Finland
Periodontitis NOS
+∞
8.6
8
*
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
16.9
8.4
13
10
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
16.9
8.4
13
10
SBB10
NOMESCO Finland
Teeth copy
9.6
8.2
17
25
SAA03
NOMESCO Finland
Extended examination of mouth
5.7
8.0
31
108
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
16.9
7.9
12
9
SAA04
NOMESCO Finland
Special inverstigation of mouth
12.9
7.6
13
13
K07.24
ICD-10 Finland
Open bite
+∞
7.5
7
*
EBB15
NOMESCO Finland
Insertion of dental implant abutment
+∞
7.5
7
*
SXC03
NOMESCO Finland
Other oral or dental procedure
+∞
6.4
6
*
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
+∞
6.4
6
*
K05.30
ICD-10 Finland
Periodontitis complex
+∞
6.4
6
*
EBB10
NOMESCO Finland
Insertion of dental implant
+∞
6.4
6
*
K05.31
ICD-10 Finland
Periodontitis pronounced
+∞
6.4
6
*
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
13.4
6.1
10
9

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
11
37
3.50
2.89
19.5
3.9
1.1
1.1
mmol/l
0.00
11
31
10
32
3.63
2.81
12.6
6.2
9.5
8.1
mmol/l
—
10
32
12
49
2.88
2.30
3.8
1.6
—
—
—
0
0
6
14
4.69
2.22
16.2
6.9
194.3
86.4
ng/l
—
6
14
5
10
5.40
2.12
1.4
1.0
—
—
—
0
0
14
67
2.49
1.98
1.4
1.4
—
—
—
0
0
6
18
3.62
1.80
4.8
2.4
0.6
0.6
%
—
6
18
6
18
3.62
1.80
4.8
2.4
0.7
1.0
%
—
6
18
16
87
2.21
1.69
8.6
4.5
—
—
—
0
0
9
37
2.73
1.57
3.1
1.5
—
—
—
0
0
6
22
2.94
1.48
9.0
2.3
128.3
140.5
g/l
—
6
22
5
19
2.80
1.24
1.2
3.4
—
—
—
0
0
0
33
0.00
1.21
0.0
1.5
—
—
—
0
0
0
33
0.00
1.21
0.0
1.5
—
—
—
0
0
0
34
0.00
1.21
0.0
1.6
—
—
—
0
0
7
31
2.45
1.15
9.6
2.6
4.7
4.8
kpa
—
7
31
7
31
2.45
1.15
10.4
4.1
—
—
—
0
0
19
126
1.80
1.12
9.9
4.7
—
—
—
0
0
9
47
2.10
1.09
1.2
1.2
—
328.0
—
0
5
7
34
2.22
1.07
10.4
3.9
5.6
6.0
kpa
—
7
34
6
27
2.38
0.97
15.7
6.6
—
—
—
0
0
17
117
1.67
0.86
1.8
1.8
90.1
94.2
pmol/l
—
7
63
0
24
0.00
0.81
0.0
1.3
—
—
—
0
0
7
38
1.97
0.77
1.7
1.5
—
—
—
0
0
5
24
2.19
0.77
14.0
4.8
1.1
1.1
mmol/l
—
5
24
5
24
2.19
0.77
6.8
3.5
—
—
—
0
0
5
24
2.19
0.77
2.6
4.1
3.4
2.2
ug/l
—
5
16
5
27
1.94
0.70
1.0
1.4
—
—
—
0
0
7
43
1.72
0.70
8.0
2.0
2.1
2.4
g/l
—
7
37
5
28
1.87
0.68
10.8
4.3
23.2
26.1
mmol/l
—
5
28
21
163
1.48
0.62
9.5
4.9
9.6
10.9
umol/l
0.44
21
156
16
117
1.53
0.62
3.6
2.0
—
—
—
0
0
23
185
1.44
0.56
5.2
3.0
0.0
0.0
estimate
—
5
34
23
186
1.42
0.54
8.1
4.5
0.0
0.0
estimate
—
5
36
13
95
1.49
0.50
14.2
4.9
—
—
—
0
0
14
104
1.47
0.50
7.9
1.9
46.9
54.7
u/l
0.77
14
98
23
189
1.39
0.48
5.2
3.1
0.0
0.0
estimate
—
5
36
8
56
1.51
0.45
1.0
1.2
—
—
—
0
0
44
407
1.53
0.43
20.6
9.6
23.3
21.0
mg/l
0.12
35
285
5
33
1.57
0.42
6.4
2.5
—
—
—
0
0
5
33
1.57
0.42
1.0
1.3
—
—
—
0
0
5
33
1.57
0.42
1.0
1.3
—
—
—
0
0
12
89
1.45
0.42
4.3
3.5
0.0
0.0
estimate
—
5
34
5
34
1.52
0.41
1.0
1.3
—
—
—
0
0
5
34
1.52
0.41
1.0
1.3
—
—
—
0
0
15
117
1.40
0.41
5.7
2.5
—
—
—
0
0
12
155
0.71
0.41
1.8
1.9
—
—
—
0
0
9
69
1.37
0.40
2.6
1.4
—
—
—
0
0
47
445
1.58
0.39
15.7
8.9
—
—
—
0
0
10
73
1.46
0.38
5.5
4.1
—
—
—
0
0
12
92
1.40
0.36
2.4
2.4
—
—
—
0
0
13
103
1.35
0.32
1.2
1.3
2.2
1.9
g/l
—
7
62
12
94
1.36
0.31
5.6
3.3
—
—
—
0
0
9
75
1.24
0.27
3.4
3.5
—
—
—
0
0
11
89
1.30
0.23
2.6
1.7
1.4
1.3
mg/l
0.05
11
73
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
20
184
1.14
0.11
23.0
7.3
0.0
0.0
e9/l
0.48
15
154
11
96
1.18
0.11
3.9
2.8
—
—
—
0
0
5
45
1.12
0.10
1.6
1.4
—
—
—
0
0
42
408
1.15
0.08
23.1
10.3
35.0
39.9
%
1.39
34
329
28
268
1.10
0.06
5.6
3.6
—
—
—
0
0
17
159
1.10
0.06
3.6
2.5
—
—
—
0
0
16
150
1.10
0.05
5.3
2.9
—
—
—
0
0
21
219
0.93
0.03
4.4
3.3
—
—
—
0
0
14
133
1.07
0.02
2.8
2.0
—
—
—
0
0
13
131
0.99
0.00
1.5
1.7
—
—
—
0
0
12
123
0.97
0.00
2.3
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
37.6
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
351.2
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
9
91
0.99
0.00
1.6
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
56
0.88
0.00
1.4
2.3
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint K11_ANKYLOSIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_ANKYLOSIS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: K11_ANKYLOSIS – Ankylosis of teeth

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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