No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
157 |
4. Check minimum number of eventsNone |
157 |
5. Include endpointsNone |
157 |
6. Filter based on genotype QC (FinnGen only) |
157 |
Control definitions (FinnGen only)
- Control exclude
- N14_FEMALEGENNONINF
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- N97
- Name in latin
- Infertilitas uterina feminae
Similar endpoints
↥List of similar endpoints to
Female infertility, uterine origin
based on the number of shared cases.
Similar with more cases:
- Female infertility
- Noninflammatory disorders of female genital tract
- Genitourinary diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 876 | 876 | - |
| Only index persons | 856 | 856 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | - |
| Only index persons | 0.03 | 0.03 | - |
| Median age at first event (years) | |||
| Whole population | - | 33.97 | - |
| Only index persons | - | 33.88 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 157 | 157 | - |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | - |
| Median age at first event (years) | 34.33 | 34.33 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 140
- Matched controls
- 1399
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N97.2
ICD-10 Finland
Female infertility of uterine origin
+∞
161.4
122
*
N97.9
ICD-10 Finland
Female infertility, unspecified
+∞
72.3
63
*
G03GA01
ATC
chorionic gonadotrophin; parenteral
65.4
49.5
56
14
LAA10
NOMESCO Finland
Percutaneous or transvaginal puncture and recovery of oocyte
585.0
44.9
42
*
H01CA02
ATC
nafarelin; nasal
98.7
39.5
42
6
N97.8
ICD-10 Finland
Female infertility of other origin
+∞
37.1
34
*
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
119.7
34.6
36
*
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
53.2
33.3
39
10
ULC02
NOMESCO Finland
Hysteroscopy
71.0
33.2
37
7
G03GA06
ATC
follitropin beta; parenteral
62.1
32.5
37
8
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
111.0
32.4
34
*
G03GA05
ATC
follitropin alfa; parenteral
53.1
30.8
36
9
G03GA02
ATC
human menopausal gonadotrophin; parenteral
47.7
30.1
36
10
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
+∞
29.2
27
*
TLW12
NOMESCO Finland
Insertion of frozen embryo
+∞
29.2
27
*
N80.1
ICD-10 Finland
Endometriosis of ovary
+∞
29.2
27
*
TLW10
NOMESCO Finland
Transfer of fresh embryo
+∞
26.9
25
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
6.3
22.7
83
261
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
6.3
22.4
83
264
G03DA04
ATC
progesterone; systemic, rectal, vaginal
25.0
21.5
30
15
N84.0
ICD-10 Finland
Polyp of corpus uteri
+∞
21.4
20
*
N97.0
ICD-10 Finland
Female infertility associated with anovulation
+∞
20.3
19
*
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
+∞
20.3
19
*
H01CC01
ATC
ganirelix; parenteral
26.2
19.0
26
12
L02AE01
ATC
buserelin; implant, nasal, parenteral
77.0
18.2
20
*
N95.1
ICD-10 Finland
Menopausal and female climacteric states
+∞
17.0
16
*
N97.4
ICD-10 Finland
Female infertility associated with male factors
+∞
17.0
16
*
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
12.8
16.7
30
29
JAH01
NOMESCO Finland
Laparoscopy
17.4
16.6
26
18
LCA06
NOMESCO Finland
Biopsy of endometrium
14.3
16.5
28
24
LA2AE
NOMESCO Finland
Ultrasound examination of ovarian cyst
179.1
15.8
16
*
G03DB01
ATC
dydrogesterone; oral
5.3
14.9
52
139
N80.9
ICD-10 Finland
Endometriosis, unspecified
+∞
14.8
14
*
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
6.6
13.8
38
75
LBF01
NOMESCO Finland
Laparoscopic perfusion of Fallopian tube
+∞
13.8
13
*
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
8.3
13.7
31
46
N97.1
ICD-10 Finland
Female infertility of tubal origin
+∞
12.7
12
*
LAA06
NOMESCO Finland
Transvaginal puncture of ovarian cyst
+∞
12.7
12
*
LCB25
NOMESCO Finland
Hysteroscopic excision of lesion
29.8
12.3
16
6
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
18.5
12.0
18
11
D25.1
ICD-10 Finland
Intramural leiomyoma of uterus
11.6
12.0
22
22
N80.4
ICD-10 Finland
Endometriosis of rectovaginal septum and vagina
+∞
11.6
11
*
TLW00
NOMESCO Finland
Insemination
+∞
11.6
11
*
TLW14
NOMESCO Finland
ICSI
+∞
11.6
11
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
3.9
11.1
56
205
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
5.8
10.9
32
68
G03GA04
ATC
urofollitropin; parenteral
118.4
10.6
11
*
6283A
ICD-9 Finland
Infertility, female, Of uterine origin[STERILITAS ET INFERTILITAS EX ORIGINE UTERI PRIM]
+∞
10.5
10
*
N85.6
ICD-10 Finland
Intrauterine synechiae
+∞
10.5
10
*
O02.1
ICD-10 Finland
Missed abortion
5.6
10.0
30
65
C539, 6666, 0
ICD-O-3
NA
59.2
9.8
11
*
LBE01
NOMESCO Finland
Laparoscopic salpingectomy
16.6
9.8
15
10
LCB14
NOMESCO Finland
Laparoscopic myolysis
106.9
9.5
10
*
Z31.2
ICD-10 Finland
In vitrofertilization
+∞
9.5
9
*
D25.0
ICD-10 Finland
Submucous leiomyoma of uterus
15.1
9.4
15
11
L02AE02
ATC
leuprorelin; implant, parenteral
15.1
9.4
15
11
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
4.8
9.4
33
85
G03GB02
ATC
clomifene; oral
10.6
9.1
17
18
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
12.7
8.8
15
13
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
6.3
8.8
23
42
LAC01
NOMESCO Finland
Laparoscopic excision of ovarian cyst
95.5
8.5
9
*
N87.1
ICD-10 Finland
Moderate cervical dysplasia
+∞
8.4
8
*
6283B
ICD-9 Finland
Infertility, female, Of uterine origin[STERILITAS ET INFERTILITAS EX ORIGINE UTERI SEC]
+∞
8.4
8
*
1413
FHL
Laparoscopy and other therapeutic procedure
15.7
8.4
13
9
N92.4
ICD-10 Finland
Excessive bleeding in the premenopausal period
35.6
8.2
10
*
D25.2
ICD-10 Finland
Subserosal leiomyoma of uterus
23.7
8.1
11
5
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
14.2
8.1
13
10
LCA30
NOMESCO Finland
Transfer of oocyte or embryo to uterus in assisted fertilisation
84.3
7.5
8
*
XLA10
NOMESCO Finland
NA
6.3
7.4
19
34
N80.81
ICD-10 Finland
Endometriosis in sacrouteral ligament
+∞
7.3
7
*
N98.1
ICD-10 Finland
Hyperstimulation of ovaries
+∞
7.3
7
*
1350
FHL
Hysteroscopy
+∞
7.3
7
*
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
+∞
7.3
7
*
1410
FHL
Laparoscopy
21.4
7.2
10
5
LCA13
NOMESCO Finland
Curettage of cervix and body of uterus
31.8
7.2
9
*
LCD04
NOMESCO Finland
Laparoscopic hysterectomy
13.0
7.2
12
10
N91.1
ICD-10 Finland
Secondary amenorrhoea
42.1
6.8
8
*
N94.1
ICD-10 Finland
Dyspareunia
73.0
6.5
7
*
N80.0
ICD-10 Finland
Endometriosis of uterus
73.0
6.5
7
*
L02BG04
ATC
letrozole; oral
5.9
6.4
17
32
TLC00
NOMESCO Finland
Insertion of intrauterine device
5.9
6.4
17
32
L02AE03
ATC
goserelin; implant
19.1
6.3
9
5
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
4.1
6.3
24
67
N95.2
ICD-10 Finland
Postmenopausal atrophic vaginitis
+∞
6.3
6
*
N80.5
ICD-10 Finland
Endometriosis of intestine
+∞
6.3
6
*
LA2JE
NOMESCO Finland
Follow-up of menstrual cycle with repeated measurement of ovarian cyst
+∞
6.3
6
*
6289A
ICD-9 Finland
Infertility, female, Of unspecified origin[STERILITAS ET INFERTILITAS MULIERIS NUD PRIM]
+∞
6.3
6
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
6.0
60
320
ULA02
NOMESCO Finland
Kolposcopy
4.4
6.0
21
54
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
24
6.80
9.17
1.7
1.5
64.4
88.4
pmol/l
0.36
15
24
25
90
3.11
5.62
2.4
1.8
3365.5
2689.3
u/l
0.10
14
33
78
536
1.90
3.82
5.3
3.5
0.0
0.0
estimate
0.50
15
95
78
537
1.90
3.79
3.3
2.5
0.1
0.0
estimate
0.47
13
98
27
125
2.40
3.75
1.3
1.2
82.5
149.4
iu/ml
—
10
55
64
418
1.90
3.62
3.6
2.5
—
—
—
0
0
14
47
3.17
3.51
1.3
1.6
—
—
—
0
0
77
542
1.83
3.38
3.6
2.6
0.0
0.0
estimate
0.00
15
94
16
61
2.81
3.25
2.4
1.8
—
—
—
0
0
5
5
10.27
3.00
2.0
1.4
—
—
—
0
0
42
264
1.81
2.57
1.1
1.2
15.8
26.7
iu/ml
—
10
82
39
242
1.81
2.48
1.2
1.2
5.5
18.2
u/ml
0.93
15
92
18
86
2.23
2.33
1.9
2.5
—
—
—
0
0
43
280
1.74
2.32
3.2
2.8
0.0
0.0
estimate
0.50
15
95
5
9
5.69
2.23
2.0
1.2
—
—
—
0
0
7
21
3.44
1.99
5.1
2.6
49.1
45.1
%
—
7
21
5
11
4.65
1.95
2.0
1.2
—
—
—
0
0
17
86
2.10
1.93
1.7
1.5
—
—
—
0
0
68
518
1.55
1.92
3.9
3.7
—
—
—
0
0
9
36
2.59
1.77
1.6
1.2
—
—
—
0
0
61
475
1.46
1.48
4.3
6.3
1.2
1.2
mmol/l
0.21
47
405
5
16
3.19
1.45
1.0
1.2
—
—
—
0
0
16
89
1.89
1.43
1.3
1.3
233.1
252.5
miu/ml
—
8
52
101
873
1.44
1.36
5.8
6.0
72.3
76.0
u/l
0.48
95
826
9
44
2.11
1.29
1.3
1.2
—
—
—
0
0
8
35
2.35
1.29
2.5
1.7
13.5
13.2
%
—
8
35
6
25
2.45
1.25
1.3
2.3
4.2
3.8
g/l
—
6
25
138
1280
1.65
1.22
10.1
9.1
19.3
19.0
mg/l
0.04
108
936
82
692
1.39
1.22
7.4
8.9
4.0
4.1
e9/l
0.06
74
613
13
72
1.88
1.19
1.5
1.6
—
—
—
0
0
44
337
1.42
1.13
1.4
1.3
—
—
—
0
0
22
150
1.54
0.99
1.4
1.6
—
—
—
0
0
16
102
1.63
0.95
2.9
3.9
4.4
4.7
pmol/l
0.72
16
93
9
52
1.77
0.94
2.2
2.0
—
—
—
0
0
6
28
2.19
0.92
1.2
1.4
—
—
—
0
0
8
42
1.95
0.90
1.0
1.9
—
—
—
0
0
11
64
1.77
0.88
1.1
1.1
—
—
—
0
0
34
260
1.39
0.88
1.6
1.6
0.8
0.7
mg/l
0.28
26
194
13
198
0.63
0.83
1.5
1.4
23.6
20.1
nmol/l
0.35
13
178
0
26
0.00
0.79
0.0
1.1
—
—
—
0
0
17
118
1.49
0.73
1.3
1.6
—
—
—
0
0
15
102
1.52
0.70
11.9
4.6
—
—
—
0
0
5
92
0.53
0.69
1.2
1.4
—
—
—
0
0
5
92
0.53
0.69
1.2
1.4
—
—
—
0
0
5
92
0.53
0.69
1.2
1.4
—
—
—
0
0
7
42
1.70
0.69
1.1
1.1
—
—
—
0
0
46
383
1.28
0.68
4.1
4.7
36.8
37.0
g/l
0.08
46
361
41
340
1.28
0.63
1.6
1.6
—
—
—
0
0
5
30
1.69
0.62
4.8
2.1
0.9
1.7
%
—
5
30
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
21
160
1.36
0.57
2.1
2.9
7.2
714.6
ng/l
0.75
13
88
6
38
1.60
0.55
1.5
1.2
—
—
—
0
0
20
153
1.35
0.53
1.6
1.6
—
—
—
0
0
17
128
1.37
0.50
1.6
1.6
—
—
—
0
0
49
426
1.22
0.50
3.2
5.2
1.2
1.2
mmol/l
0.21
42
399
6
94
0.62
0.43
1.5
1.5
—
—
—
0
0
20
159
1.30
0.43
3.0
2.3
2.4
2.4
mmol/l
0.24
20
139
5
33
1.53
0.41
1.4
2.0
—
—
—
0
0
5
33
1.53
0.41
1.2
1.9
—
—
—
0
0
9
69
1.32
0.38
1.0
1.9
—
—
—
0
0
6
42
1.45
0.36
1.3
3.2
26.7
176.7
ng/l
—
6
36
31
355
0.84
0.33
1.9
1.7
109.6
94.6
pmol/l
0.82
20
196
11
83
1.35
0.33
1.8
1.5
—
—
—
0
0
119
1145
1.16
0.30
3.5
3.7
—
—
—
0
0
25
214
1.20
0.30
2.2
1.8
—
—
—
0
0
14
112
1.27
0.29
1.4
2.3
354.9
390.9
nmol/l
0.42
14
104
11
85
1.32
0.29
1.1
1.0
—
—
—
0
0
129
1251
1.17
0.28
9.4
9.2
3.9
3.9
mmol/l
0.03
129
1214
152
1496
1.50
0.26
16.3
13.9
133.6
133.3
g/l
0.12
152
1474
116
1198
0.88
0.25
7.9
7.5
90.0
91.2
ml/min/173m2
0.30
100
947
27
238
1.16
0.24
2.3
2.0
—
—
—
0
0
5
38
1.33
0.23
1.6
1.2
—
—
—
0
0
128
1247
1.14
0.22
9.4
9.2
139.5
139.7
mmol/l
0.48
128
1210
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
31.4
—
0
5
0
12
0.00
0.21
0.0
1.8
—
12.6
—
0
12
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
10
80
1.27
0.21
1.9
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
11
90
1.24
0.20
1.4
1.3
—
—
—
0
0
13
110
1.20
0.18
1.5
1.2
64.7
104.0
u/ml
0.54
13
102
15
170
0.87
0.14
1.3
1.6
—
—
—
0
0
139
1371
1.12
0.12
11.1
9.6
66.0
65.6
umol/l
0.15
139
1371
23
250
0.91
0.12
1.6
1.7
—
—
—
0
0
33
310
1.08
0.11
1.2
1.2
0.5
0.9
u/ml
—
9
82
126
1279
0.92
0.10
3.3
3.4
4.9
4.9
mmol/l
0.07
121
1210
5
46
1.09
0.09
3.0
9.8
2.1
1.1
%
—
5
46
49
470
1.06
0.09
2.6
2.1
78.1
71.8
nmol/l
0.99
49
443
5
48
1.04
0.09
1.4
6.6
24.3
24.4
mmol/l
—
5
48
6
53
1.14
0.09
1.7
1.5
—
—
—
0
0
127
1283
0.95
0.05
9.8
10.8
38.2
39.8
%
1.07
108
1068
32
307
1.05
0.05
2.6
2.5
14.0
22.9
ng/l
0.59
14
140
10
101
0.99
0.00
6.6
6.7
1.1
1.0
mmol/l
—
10
94
31
312
0.99
0.00
2.9
2.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
37.5
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
481.3
—
0
6
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.9
—
18.8
—
0
8
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
0.2
—
0
8
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
4.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
4.5
—
—
—
0
0
7
71
0.99
0.00
1.9
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
1.2
—
0
5
0
6
0.00
0.00
0.0
1.2
—
89.5
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_FIUTERINE and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have N14_FIUTERINE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: N14_FIUTERINE – Female infertility, uterine origin
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data