Dyslexia and other symbolic dysfunctions, not elsewhere classified

R18_DYSLE_OTHER_SYMBO_DYSFU_NOT_ELSEW_CLASSIFIED

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — R48 Cause of death: ICD-10 — R48 2 out of 7 registries used, show all original rules.	143
4. Check minimum number of events None	143
5. Include endpoints None	143
6. Filter based on genotype QC (FinnGen only)	143

Control definitions (FinnGen only)

Control exclude: R18_SYMPTOMS_SIGNS_INVOLVI_SPEECH_VOICE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: R4[7-9]
Name in latin: Dyslexia et aliae dysfunctiones discretionis symbolorum non alibi classificatae

NAME	R18_DYSLE_OTHER_SYMBO_DYSFU_NOT_ELSEW_CLASSIFIED
CONTROL_EXCLUDE	R18_SYMPTOMS_SIGNS_INVOLVI_SPEECH_VOICE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	R48
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	R48
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Dyslexia and other symbolic dysfunctions, not elsewhere classified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	143	79	64
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	55.51	50.77	61.35

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
128: Matched controls
1279

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

R48.0

ICD-10 Finland

Dyslexia and alexia

+∞

62.8

R48.2

ICD-10 Finland

Apraxia

+∞

33.9

R48.8

ICD-10 Finland

Other and unspecified symbolic dysfunctions

+∞

23.7

R48

ICD-10 Finland

Dyslexia and other symbolic dysfunctions, not elsewhere classified

+∞

13.8

R48.1

ICD-10 Finland

Agnosia

+∞

9.5

R47.0

ICD-10 Finland

Dysphasia and aphasia

96.1

8.5

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

6.4

7.8

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

4.5

7.5

AA1AD

NOMESCO Finland

CT of head and brain

3.2

7.4

183

R53

ICD-10 Finland

Malaise and fatigue

3.3

7.0

150

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

4.7

6.6

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

4.4

6.5

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044290) Cell count panel - Cerebral spinal fluid

5.90

5.40

1.0

1.2

—

(3016018) Differential panel - Cerebral spinal fluid

14.61

4.62

1.0

1.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

223

2.18

3.97

1.3

2.88

1.33

u/ml

0.48

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

12.44

3.79

1.2

1.6

1.98

1.89

mmol/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

153

2.31

3.77

3.1

2.7

2.61

1.83

e6/l

0.25

(3019150) Specific gravity of Urine by Refractometry

233

2.07

3.51

4.6

3.8

1.02

1.01

kg/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

408

1.92

3.49

2.1

1.9

84.10

91.29

pmol/l

0.69

207

(3022217) INR in Platelet poor plasma by Coagulation assay

124

2.34

3.40

21.8

19.5

1.40

1.33

inr

—

(3023410) Appearance of Cerebral spinal fluid

8.88

3.29

1.2

1.0

—

(3028707) Methadone [Presence] in Urine by Screen method

4.50

3.05

1.1

1.9

—

(3002582) Erythrocytes [#/volume] in Urine

327

1.87

3.03

3.4

3.2

26.95

245.14

e6/l

0.60

260

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.88

2.99

1.1

1.3

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

6.90

2.89

1.2

1.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

6.90

2.89

1.0

1.2

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

2.77

2.80

2.9

3.3

0.05

0.12

e6/l

0.60

(3019309) Folate [Moles/volume] in Red Blood Cells

180

2.00

2.77

1.6

1.7

830.88

1177.46

nmol/l

2.31

141

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

6.20

2.72

1.0

1.2

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

4.39

2.72

1.6

1.9

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

5.64

2.57

1.0

1.2

—

(3011288) Drugs identified in Urine by Screen method

2.97

2.54

1.3

1.6

—

(3026008) Bacteria identified in Urine by Culture

344

1.75

2.50

3.8

3.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

488

1.70

2.49

6.0

7.7

1.21

1.22

mmol/l

0.28

405

(42870588) Differential panel, method unspecified - Blood

328

1.75

2.46

5.6

5.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

724

1.71

2.40

5.6

4.4

—

453.80

—

(3007164) IgA [Mass/volume] in Serum or Plasma

208

1.83

2.29

1.5

2.23

2.48

g/l

0.24

127

(3000764) Benzodiazepines [Presence] in Urine

2.55

2.27

1.2

1.5

—

(3018095) Leukocytes [#/volume] in Urine

380

1.68

2.23

4.5

3.6

33.81

62.34

e6/l

0.73

275

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

805

1.69

2.20

4.8

3.7

14.47

14.70

pmol/l

0.40

711

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

203

1.81

2.18

3.2

3.1

25.00

94.48

ng/l

1.10

152

(3027944) Amphetamines [Presence] in Urine

2.45

2.12

1.2

1.5

—

(3027008) Opiates [Presence] in Urine

2.45

2.12

1.2

1.4

—

(3028300) Cannabinoids [Presence] in Urine

2.45

2.12

1.2

1.4

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

5.14

2.09

1.4

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

368

1.65

2.08

3.9

3.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

158

1.87

2.08

2.9

2.5

0.64

0.96

e6/l

0.40

(3033705) Calcium.ionized [Moles/volume] in Venous blood

4.13

2.06

2.7

3.5

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.93

2.04

5.6

6.3

—

(3016879) Cocaine [Presence] in Urine

2.48

2.01

1.1

1.5

—

(3013512) EKG study

284

1.68

1.99

5.1

4.1

—

(3041354) Potassium [Moles/volume] in Venous blood

3.86

1.95

2.7

3.4

4.22

4.11

mmol/l

—

(3035285) Chloride [Moles/volume] in Venous blood

3.86

1.95

2.7

3.4

110.17

105.31

mmol/l

—

(3044640) Blood type and Crossmatch panel - Blood

320

1.64

1.95

2.1

2.2

—

(36660697) Celiac disease serology panel - Serum

2.15

1.94

1.2

1.1

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

610

1.57

1.89

9.2

9.5

4.43

4.24

e9/l

0.25

540

(40758558) Short blood count panel - Blood

271

1.66

1.87

5.2

6.7

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

113

982

1.72

1.87

6.2

4.4

2.16

1.90

mu/l

0.26

104

882

(3030467) Casts [#/volume] in Urine by Automated count

297

1.64

1.87

3.3

3.0

0.37

0.27

e6/l

0.15

230

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.24

1.77

1.2

1.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.40

1.75

1.1

1.6

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

3.94

1.73

1.2

1.3

—

(3032080) INR in Blood by Coagulation assay

410

1.55

1.73

6.3

8.2

1.15

1.25

inr

0.44

132

(3008037) Lactate [Moles/volume] in Venous blood

2.89

1.67

4.7

3.6

1.74

1.54

mmol/l

—

(3038515) Glucose [Moles/volume] in Venous blood

2.89

1.67

4.7

3.6

11.23

7.65

mmol/l

—

(3048689) Calprotectin [Mass/mass] in Stool

146

1.77

1.64

1.7

2.0

92.73

129.02

ug/g

0.39

116

(3006315) Basophils [#/volume] in Blood

514

1.49

1.51

5.8

5.3

0.04

e9/l

0.55

457

(3001604) Monocytes [#/volume] in Blood

514

1.49

1.51

5.8

5.2

0.60

0.58

e9/l

0.19

453

(3000330) Specific gravity of Urine by Test strip

2.13

1.48

3.3

4.5

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.39

1.46

2.4

2.9

0.63

0.67

—

(3021589) Normoblasts [#/volume] in Blood

452

1.48

1.43

8.4

9.6

0.00

0.01

e9/l

0.52

372

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

236

1.58

1.43

1.9

2.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.33

1.43

2.4

2.9

2.02

1.06

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.93

1.35

1.3

1.2

42.86

192.61

iu/ml

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.93

1.35

2.1

2.3

2.61

4.57

ug/l

0.93

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

188

1.61

1.35

1.3

14.00

31.49

iu/ml

—

(3022621) pH of Urine by Test strip

1.97

1.33

3.4

2.6

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.36

1.29

1.8

1.5

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

558

1.42

1.24

6.2

6.0

13.34

10.63

umol/l

0.63

526

(3037467) Urinalysis macro (dipstick) panel - Urine

757

1.42

1.22

5.1

4.3

—

(3002032) Base excess in Venous blood by calculation

1.86

1.22

3.4

4.1

2.47

2.30

mmol/l

0.13

(3012544) pH of Venous blood

1.86

1.22

3.4

4.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

219

1.53

1.21

1.8

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

112

0.43

1.19

1.0

1.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

391

1.43

1.18

4.5

3.9

39.73

38.58

ng/l

0.02

261

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

822

1.42

1.16

7.7

6.9

75.05

74.66

u/l

0.03

756

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.06

1.14

4.8

4.3

27.10

25.20

mmol/l

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.43

1.10

1.2

1.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.43

1.10

1.2

1.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.99

1.09

4.0

4.5

139.90

127.96

g/l

—

(3019198) Lymphocytes [#/volume] in Blood

540

1.37

1.06

5.9

5.3

1.75

1.96

e9/l

0.64

486

(3021960) Folate [Moles/volume] in Serum or Plasma

243

1.47

1.06

1.5

1.6

20.17

23.15

nmol/l

0.56

197

(3045414) Leukocytes [Presence] in Urine

2.02

1.06

1.4

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

307

1.42

1.03

4.2

3.5

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.87

1.01

3.5

2.3

185.91

131.28

ng/l

0.33

(4010399)

1.87

1.01

1.6

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

118

1.60

0.96

1.3

1.5

—

(3000492) Spirometry study

1.73

0.95

1.2

1.5

—

(3009261) Glucose [Presence] in Urine by Test strip

538

1.34

0.95

4.6

3.7

0.00

estimate

0.00

(3035350) Ketones [Presence] in Urine by Test strip

531

1.33

0.91

4.6

3.7

0.00

estimate

—

102

(36304419) Bacteria [Presence] in Urine

287

1.39

0.90

3.2

2.9

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

117

1083

1.44

0.90

17.9

13.6

20.15

22.69

mg/l

0.45

840

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.91

0.89

6.4

3.7

47.35

45.65

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

181

1.46

0.87

1.2

1.3

4.42

8.40

u/ml

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.98

0.85

1.2

1.3

—

(3044889) 12 lead EKG panel

713

1.31

0.84

3.6

3.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

489

1.31

0.82

3.9

4.5

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.80

0.0

1.2

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.70

0.77

2.4

3.8

89.15

68.26

ng/l

0.32

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.21

0.77

1.4

1.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

534

1.28

0.73

6.2

5.1

0.00

estimate

0.00

104

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

439

1.29

0.71

2.4

2.2

70.13

74.85

nmol/l

0.62

380

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.74

0.71

1.1

1.5

—

(3029937) Albumin [Presence] in Urine by Test strip

289

1.33

0.71

4.7

3.8

0.00

0.01

estimate

0.50

(3014051) Protein [Presence] in Urine by Test strip

1.81

0.67

1.4

2.0

—

(3019225) pH of Specimen

1.54

0.66

3.0

3.8

—

(3023368) Bacteria identified in Blood by Culture

283

1.31

0.65

4.5

3.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

416

1.27

0.64

4.9

3.9

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.63

0.62

3.0

2.2

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.63

0.62

6.1

19.4

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.55

0.62

5.7

7.8

1.25

1.19

mmol/l

0.12

(4094501)

1.69

0.62

1.0

1.1

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.60

0.61

6.6

11.1

24.62

25.06

mmol/l

—

(21494755) Public health laboratory ask at order entry panel

113

0.60

0.61

1.3

—

(3022313) Gas panel - Capillary blood

1.57

0.60

1.0

3.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.60

0.0

3.4

—

22.07

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

193

0.70

0.58

1.1

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

151

1.38

0.58

2.5

2.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

243

1.30

0.56

5.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

100

0.58

0.54

1.0

1.7

—

(40768443) Skin Pathology biopsy report

1.56

0.53

1.3

1.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

709

1.22

0.53

3.6

2.9

45.60

43.76

u/l

0.11

662

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.52

0.52

1.2

2.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

109

1028

1.25

0.50

5.1

4.3

6.02

5.92

mmol/l

0.30

100

935

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

219

1.29

0.50

1.5

1.7

1.22

1.18

mg/l

0.04

174

(3012095) Magnesium [Moles/volume] in Serum or Plasma

147

1.34

0.48

2.3

3.4

0.83

0.82

mmol/l

0.17

138

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

106

999

1.24

0.48

16.3

12.5

85.50

83.33

ml/min/173m2

0.41

802

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

103

971

1.22

0.44

6.3

5.4

40.47

39.63

mmol/mol

0.30

900

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

215

1.26

0.42

1.4

1.7

411.90

446.80

pmol/l

0.25

184

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.41

0.0

2.8

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.41

0.0

2.8

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.41

0.0

1.6

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.4

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

143

1.30

0.39

2.2

2.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

108

1.33

0.37

6.2

6.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

228

1.23

0.37

4.2

3.6

—

(1002224) Polysomnography panel

1.48

0.36

1.0

1.1

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.45

0.36

1.7

3.7

25.33

24.65

mmol/l

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

258

1.21

0.35

2.1

1.9

2.37

2.92

mg/l

1.33

219

(3042936) Bacteria identified in Isolate by Culture

155

1.26

0.34

3.3

2.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

130

1.26

0.30

2.0

1.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

226

0.82

0.30

5.8

4.0

22.54

20.64

—

108

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

736

1.13

0.27

3.2

—

(3019060) Gas panel - Arterial blood

1.25

0.26

2.0

10.8

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

105

1011

1.15

0.25

4.2

3.6

1.25

1.26

mmol/l

0.08

919

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

133

1.23

0.25

2.0

1.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

111

1075

1.15

0.23

5.1

4.5

2.64

2.71

mmol/l

0.37

106

979

(3049717) Cytology report of Urine Cyto stain

1.33

0.23

1.4

3.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.27

0.23

1.7

1.5

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.75

0.23

1.1

1.6

—

(40761536) Microorganisms panel - Urine sediment

0.73

0.23

4.6

3.7

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.29

0.23

1.2

2.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

135

1.21

0.22

1.4

1.9

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.23

0.22

1.6

1.4

—

(40768804) Tissue Pathology biopsy report

425

1.12

0.22

1.8

2.0

—

(3045788) Cell count panel - Pleural fluid

0.00

0.21

0.0

1.3

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.0

—

(4281824)

0.00

0.21

0.0

1.0

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

5.7

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.3

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3028308) Erythrocytes [#/volume] in Pleural fluid

0.00

0.21

0.0

1.3

—

17346.67

—

(3012441) Differential panel - Pleural fluid

0.00

0.21

0.0

1.3

—

(3023199) Leukocytes [#/volume] in Pleural fluid

0.00

0.21

0.0

1.3

—

2113.14

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.21

0.0

4.2

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.1

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.21

0.0

3.5

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.5

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

2.2

—

90.84

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.7

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.0

—

(40768797) Stomach Pathology biopsy report

133

0.81

0.20

1.0

1.2

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.20

0.0

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.14

0.17

1.4

2.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

293

1.12

0.17

3.8

3.7

6.87

10.17

mg/mmol

0.24

185

(3027945) Reticulocytes/100 erythrocytes in Blood

120

0.82

0.17

1.7

2.8

1.43

1.69

—

104

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.75

0.17

1.0

1.5

—

(3000991) Gas panel - Venous blood

1.19

0.17

5.0

10.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.15

0.16

2.3

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.78

0.16

1.0

1.5

—

(3002256) Pathology report gross observation

129

0.84

0.15

1.0

1.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

108

1054

1.10

0.15

4.6

3.9

1.41

1.46

mmol/l

0.59

102

964

(4035726)

0.83

0.14

1.3

—

(3003338) MCHC [Mass/volume]

934

1.08

0.14

24.6

17.0

333.14

332.12

g/l

0.59

928

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

108

1058

1.08

0.12

4.8

4.0

4.48

4.60

mmol/l

0.56

101

974

(46235355) HIV 1 and 2 tests - Meaningful Use set

241

1.10

0.11

2.0

1.8

—

(3007461) Platelets [#/volume] in Blood

124

1222

1.11

0.11

26.5

19.3

247.06

249.10

e9/l

0.14

119

1188

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

183

1.11

0.11

2.0

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

125

1.13

0.10

1.5

1.6

—

(3008898) HLA-B27 [Presence]

1.17

0.10

1.2

1.1

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.17

0.10

1.0

3.6

24.58

25.03

mmol/l

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

1.14

0.10

1.0

2.3

32.16

40.77

u/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

0.83

0.08

1.2

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.05

0.08

4.3

1.5

—

(3022145) Colonoscopy Study observation

108

1.12

0.07

1.2

1.3

—

(3012516) Albumin [Mass/volume] in Urine

275

0.93

0.07

2.8

3.0

48.14

536.66

mg/l

0.84

173

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

104

0.86

0.06

4.1

3.5

—

(40761511) CBC panel - Blood by Automated count

116

1148

1.06

0.05

18.1

12.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

209

1.06

0.05

1.2

1.7

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

117

1159

1.05

0.04

11.5

9.4

24.45

24.84

u/l

0.11

111

1110

(3000494) Fungus identified in Specimen by Culture

119

0.92

0.04

1.7

1.5

—

(3009542) Hematocrit [Volume Fraction] of Blood

103

1021

1.03

0.02

18.7

13.9

39.23

40.18

0.39

757

(3003694) ABO and Rh group [Type] in Blood

318

0.97

0.02

1.3

1.5

—

(1761868) Lipid panel - Serum or Plasma

379

1.00

0.00

2.5

2.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

148

1.02

0.00

2.4

1.7

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

0.97

0.00

1.9

2.5

0.23

0.22

g/l

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

(3025941) Bacteria identified in Stool by Culture

1.00

0.00

1.1

1.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3004451) EKG impression Narrative

0.00

0.0

1.4

—

(3005353) Prothrombin activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

98.40

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

1.0

—

125.60

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

4.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.7

—

(4146454)

0.00

0.0

1.4

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.1

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

2.0

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.2

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3004409) Coagulation factor X activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

113.00

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

149.60

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

2.0

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.5

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.2

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.3

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3014891) Appearance of Pleural fluid

0.00

0.0

1.2

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.4

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.5

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.7

—

(3035880) pH of Pleural fluid

0.00

0.0

1.1

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

3.4

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

1.6

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

38.09

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

1.7

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.84

0.00

1.0

1.4

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.3

—

14.43

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.2

—

(3011648) Oxygen content in Venous blood

0.00

0.0

3.0

—

11.12

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.2

—

(3000012) Reticulocyte production index

0.00

0.0

1.6

—

(40761535) Cells panel - Urine sediment

0.93

0.00

6.0

3.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.94

0.00

3.9

1.6

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.3

—

17.52

—

(3041806) Other cells [#/volume] in Blood by Manual count

0.00

0.0

1.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.1

—

(3017704) Immunofixation for Urine

0.00

0.0

1.2

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.3

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: R18_DYSLE_OTHER_SYMBO_DYSFU_NOT_ELSEW_CLASSIFIED – Dyslexia and other symbolic dysfunctions, not elsewhere classified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Dyslexia and other symbolic dysfunctions, not elsewhere classified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Dyslexia and other symbolic dysfunctions, not elsewhere classified (R18_DYSLE_OTHER_SYMBO_DYSFU_NOT_ELSEW_CLASSIFIED)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints