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This is a non-core endpoint: only basic statistics are computed.

Frostbite involving multiple body regions and unspecified frostbite

ST19_FROST_INVOLVI_MULTIPLE_BODY_REGIONS_UNSPE_FROST

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 T35
  • Cause of death: ICD-10 T35

2 out of 7 registries used, show all original rules.

76

4. Check minimum number of events

None

76

5. Include endpoints

None

76

6. Filter based on genotype QC (FinnGen only)

76

Control definitions (FinnGen only)

Control exclude
ST19_FROSTBITE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
T3[3-5]
Name in latin
Congelatio multarum regionum corporis sive non specificata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 76 22 54
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 53.85 57.81 52.24

-FinnGen-

Age distribution of first events

0203040506070800246810121416AgeIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230246810121416YearIndividuals

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
64
Matched controls
638
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
X31
ICD-10 Finland
Exposure to excessive natural cold
+∞
30.7
27
*
T35.5
ICD-10 Finland
Unspecified frostbite of lower limb
+∞
24.5
22
*
T35.4
ICD-10 Finland
Unspecified frostbite of upper limb
+∞
19.8
18
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
21.7
15.6
23
16
T68
ICD-10 Finland
Hypothermia
+∞
11.8
11
*
T35.0
ICD-10 Finland
Superficial frostbite involving multiple body regions
+∞
11.8
11
*
N07BB01
ATC
disulfiram; oral
23.9
10.9
15
8
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
40.0
10.8
13
*
NDQ20
NOMESCO Finland
Amputation of finger
+∞
8.5
8
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
12.2
7.4
13
13
SPAT1148
SPAT
Treatment of chronic ulcer or burn
6.8
7.4
19
37
AA1AD
NOMESCO Finland
CT of head and brain
5.1
7.2
25
71
G72.8
ICD-10 Finland
Other specified myopathies
44.9
6.9
8
*
F10.20
ICD-10 Finland
Alcohol dependence currently independent
44.9
6.9
8
*
P15
ICPC
Chronic alcohol abuse
20.6
6.5
9
5
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
+∞
6.3
6
*
T33.5
ICD-10 Finland
Superficial frostbite of wrist and hand
+∞
6.3
6
*
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
+∞
6.3
6
*
T35.7
ICD-10 Finland
Unspecified frostbite of unspecified site
+∞
6.3
6
*
X59
ICD-10 Finland
Exposure to unspecified factor
4.3
6.0
25
83
S97
ICPC
Chronic ulcer skin
12.9
6.0
10
9

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
64
4.72
8.05
8.3
18.2
1.73
1.61
mmol/l
0.04
18
53
38
174
3.37
6.33
3.9
2.4
1128.68
297.84
u/l
0.50
38
165
20
68
3.63
5.18
2.8
1.4
—
—
—
0
0
32
152
2.91
4.75
5.8
4.2
—
—
—
0
0
14
39
4.17
4.74
7.1
7.3
24.71
24.37
mmol/l
0.12
14
39
14
48
3.35
3.51
11.0
8.6
—
—
—
0
0
12
37
3.66
3.51
4.3
18.9
—
—
—
0
0
34
200
2.27
2.98
5.6
4.1
1064.34
37.05
ng/l
0.48
28
135
8
18
4.83
2.88
7.0
6.9
—
—
—
0
0
25
135
2.27
2.63
3.4
3.0
—
—
—
0
0
25
135
2.27
2.63
5.9
3.6
0.00
0.00
estimate
—
9
48
12
45
2.98
2.59
2.4
4.0
—
—
—
0
0
19
92
2.42
2.54
2.4
1.8
30.64
29.28
s
0.32
19
92
6
12
5.32
2.45
2.0
1.4
—
—
—
0
0
31
191
2.05
2.31
4.5
5.9
—
—
—
0
0
16
75
2.44
2.28
3.6
2.3
—
—
—
0
0
8
24
3.60
2.25
2.9
1.4
—
—
—
0
0
38
256
1.97
2.18
5.4
4.6
0.00
0.00
estimate
—
9
49
35
231
1.95
2.11
9.1
7.2
1.33
1.21
inr
0.30
11
63
8
26
3.31
2.08
2.9
1.3
—
—
—
0
0
8
26
3.31
2.08
2.9
1.4
—
—
—
0
0
8
26
3.31
2.08
2.9
1.3
—
—
—
0
0
37
253
1.90
1.98
11.0
9.7
1.19
1.21
mmol/l
0.69
32
216
9
34
2.86
1.94
14.9
25.0
—
—
—
0
0
38
265
1.87
1.90
4.7
3.4
0.00
0.00
estimate
—
9
46
27
169
1.93
1.86
2.7
2.5
—
—
—
0
0
5
13
4.04
1.74
2.6
2.9
—
—
—
0
0
37
262
1.80
1.71
4.8
3.3
0.00
0.00
estimate
—
7
49
6
19
3.34
1.69
3.2
1.3
—
—
—
0
0
6
19
3.34
1.69
5.2
1.4
—
—
—
0
0
7
25
2.98
1.69
3.1
1.4
—
—
—
0
0
11
50
2.40
1.66
1.4
1.8
—
—
—
0
0
21
126
1.92
1.62
4.6
3.3
—
—
—
0
0
6
20
3.16
1.61
2.5
1.3
—
—
—
0
0
5
15
3.49
1.55
4.0
2.5
4.82
5.33
kpa
—
5
15
5
15
3.49
1.55
4.0
2.5
8.94
8.59
kpa
—
5
15
44
335
1.74
1.54
11.2
10.8
4.22
4.09
e9/l
0.13
36
291
7
28
2.65
1.49
3.1
4.9
142.71
120.71
g/l
—
7
28
14
232
0.51
1.42
2.3
2.5
—
—
—
0
0
37
274
1.68
1.39
5.1
6.8
0.04
0.04
e9/l
0.32
31
243
0
39
0.00
1.38
0.0
1.1
—
117.77
—
0
12
38
284
1.68
1.38
5.2
6.8
1.79
1.77
e9/l
0.06
33
256
37
275
1.67
1.37
5.1
6.7
0.63
0.59
e9/l
0.42
30
242
9
44
2.18
1.32
3.2
3.6
—
—
—
0
0
6
25
2.52
1.27
3.5
2.6
1.28
1.36
%
—
6
25
23
153
1.72
1.26
2.5
3.1
8.71
7.78
mmol/l
0.36
17
134
13
213
0.53
1.25
2.0
1.9
—
—
—
0
0
29
209
1.63
1.17
4.3
3.2
—
—
—
0
0
46
371
1.61
1.17
4.3
4.0
—
—
—
0
0
20
132
1.70
1.12
3.6
7.2
—
—
—
0
0
26
186
1.60
1.07
3.0
2.5
116.16
59.01
e6/l
0.22
21
146
23
162
1.60
1.00
3.1
2.5
—
—
—
0
0
0
31
0.00
0.99
0.0
1.0
—
—
—
0
0
29
217
1.54
0.98
3.1
2.9
343.10
24.62
e6/l
0.45
21
153
0
32
0.00
0.97
0.0
1.6
—
—
—
0
0
6
28
2.24
0.94
7.8
1.8
—
—
—
0
0
20
141
1.57
0.86
2.1
3.2
13.20
76.65
mg/l
—
10
97
8
48
1.74
0.81
1.3
1.5
—
—
—
0
0
0
25
0.00
0.80
0.0
1.6
—
—
—
0
0
11
67
1.75
0.80
1.5
1.8
—
—
—
0
0
5
24
2.16
0.76
4.0
5.0
26.46
24.47
mmol/l
—
5
24
20
147
1.49
0.71
2.5
4.2
1.97
12.20
mg/mmol
—
9
96
7
43
1.69
0.69
2.9
3.4
—
—
—
0
0
8
51
1.63
0.63
1.5
1.6
—
—
—
0
0
0
22
0.00
0.60
0.0
1.3
—
0.25
—
0
22
31
255
1.36
0.60
13.3
9.4
0.00
0.00
e9/l
0.50
24
208
0
23
0.00
0.59
0.0
1.3
—
1.21
—
0
23
65
603
1.54
0.59
25.6
13.1
22.49
24.36
mg/l
0.21
54
466
13
92
1.50
0.55
2.2
2.7
2.46
2.45
mmol/l
—
7
76
13
93
1.48
0.52
2.0
1.7
—
—
—
0
0
61
564
1.41
0.51
4.9
4.2
5.88
5.93
mmol/l
0.12
52
523
46
410
1.31
0.48
4.8
3.8
—
—
—
0
0
67
634
1.48
0.48
26.0
12.1
—
—
—
0
0
18
142
1.35
0.44
4.3
3.0
—
—
—
0
0
5
32
1.60
0.43
1.8
2.0
—
—
—
0
0
48
523
0.78
0.42
4.1
4.2
1.90
1.89
mu/l
0.02
41
478
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
19
0.00
0.39
0.0
13.4
—
—
—
0
0
11
82
1.40
0.36
1.8
1.7
—
—
—
0
0
8
66
1.24
0.28
1.4
1.3
—
—
—
0
0
58
607
0.81
0.25
4.5
4.5
2.65
2.78
mmol/l
0.44
53
560
63
604
1.25
0.24
30.2
15.7
139.32
139.65
mmol/l
0.37
63
590
5
40
1.27
0.23
1.2
2.8
—
—
—
0
0
5
41
1.23
0.22
1.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
69.80
—
0
5
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
4.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
3.5
—
—
—
0
0
6
48
1.27
0.21
1.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
57
593
0.84
0.19
4.0
4.2
4.49
4.61
mmol/l
0.36
52
553
17
148
1.19
0.19
3.9
3.7
—
—
—
0
0
53
506
1.16
0.18
29.7
16.6
13.88
13.55
%
1.19
53
498
5
68
0.72
0.17
1.0
1.2
—
—
—
0
0
63
609
1.20
0.17
30.1
15.6
3.98
3.99
mmol/l
0.05
63
594
20
178
1.17
0.17
1.4
1.4
—
—
—
0
0
57
591
0.86
0.16
3.7
4.1
1.36
1.37
mmol/l
0.05
52
546
6
78
0.75
0.16
1.0
1.3
—
—
—
0
0
21
190
1.15
0.15
2.2
2.0
85.96
97.49
pmol/l
0.49
12
87
58
563
1.13
0.11
26.0
14.4
40.81
41.14
%
0.16
37
433
5
47
1.07
0.09
2.4
1.7
28.40
38.23
nmol/l
—
5
47
15
136
1.13
0.09
4.4
5.5
—
—
—
0
0
6
57
1.06
0.09
1.5
1.3
—
—
—
0
0
6
58
1.04
0.08
4.2
1.5
434.17
400.57
nmol/l
—
6
51
13
118
1.12
0.07
2.2
2.0
—
—
—
0
0
14
142
0.98
0.00
1.4
2.6
381.29
5015.13
umol/l
0.78
14
119
57
575
0.97
0.00
3.3
3.8
1.37
1.34
mmol/l
0.15
52
534
0
7
0.00
0.00
0.0
3.6
—
4.07
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
3.6
—
107.29
—
0
7
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.6
—
1.60
—
0
9
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
4.9
—
—
—
0
0
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
6
69
0.86
0.00
1.2
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.6
—
8.60
—
0
9
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ST19_FROST_INVOLVI_MULTIPLE_BODY_REGIONS_UNSPE_FROST – Frostbite involving multiple body regions and unspecified frostbite

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).