Benign neoplasm: Mediastinum

CD2_BENIGN_MEDIASTINUM

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D15.2& Hospital discharge: ICD-9 — 2125 Hospital discharge: ICD-8 — 2125 Cause of death: ICD-10 — D15.2& Cause of death: ICD-9 — 2125 Cause of death: ICD-8 — 2125 2 out of 7 registries used, show all original rules.	117
4. Check minimum number of events None	117
5. Include endpoints None	117
6. Filter based on genotype QC (FinnGen only)	117

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D15
Name in latin: Neoplasma benignum mediastini

NAME	CD2_BENIGN_MEDIASTINUM
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D152
HD_ICD_9	2125
HD_ICD_8	2125
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D152
COD_ICD_9	2125
COD_ICD_8	2125
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Mediastinum based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Benign neoplasm: Mediastinum

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	865	500	354
Only index persons	693	417	276
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.02	0.01
Median age at first event (years)
Whole population	47.33	49.66	43.59
Only index persons	43.93	47.08	39.17

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	117	67	50
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	50.04	50.28	49.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
105: Matched controls
1051

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D15.2

ICD-10 Finland

Benign neoplasm: Mediastinum

+∞

94.6

21250

ICD-8 Finland

Benign neoplasm of respiratory system, Mediastinum

+∞

20.5

GEB30

NOMESCO Finland

Mediastinotomy and excision of lesion

+∞

17.1

D38.3

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Mediastinum

+∞

17.1

GEC24

NOMESCO Finland

Thoracoscopic thymectomy

+∞

11.7

R91

ICD-10 Finland

Abnormal findings on diagnostic imaging of lung

6.7

11.2

2125A

ICD-9 Finland

Benign neoplasm of respiratory and intrathoracic organs, Mediastinum

+∞

10.6

D15.0

ICD-10 Finland

Benign neoplasm: Thymus

+∞

7.4

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.0

6.7

361

GEA00

NOMESCO Finland

Mediastinoscopy

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

468

3.38

8.70

6.7

7.9

1.2

mmol/l

1.57

403

(3014576) Chloride [Moles/volume] in Serum or Plasma

125

3.28

7.08

6.4

6.8

105.4

103.7

mmol/l

1.24

120

(3032080) INR in Blood by Coagulation assay

403

2.83

7.01

7.3

1.2

inr

0.10

117

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

4.25

6.37

6.0

9.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

249

2.67

6.07

2.3

2.5

—

(3000991) Gas panel - Venous blood

3.34

5.96

7.1

9.3

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

108

2.95

5.17

7.4

7.1

5.3

5.2

kpa

0.38

103

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

324

2.40

5.07

3.2

3.1

35.9

30.4

u/l

0.31

306

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.41

4.94

5.8

5.4

24.9

25.0

mmol/l

0.07

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

463

2.36

4.81

3.7

4.1

—

(3018418) pH of Serum or Plasma

305

2.27

4.43

4.0

4.2

7.4

—

(42870588) Differential panel, method unspecified - Blood

341

2.23

4.34

6.3

5.4

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

3.15

3.80

9.6

24.2

24.5

mmol/l

0.11

(3044640) Blood type and Crossmatch panel - Blood

335

2.06

3.56

2.8

2.4

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

183

2.21

3.44

3.6

3.3

78.6

70.9

ng/l

0.05

149

(4035726)

107

2.43

3.23

1.5

1.3

—

(3023368) Bacteria identified in Blood by Culture

260

2.03

3.20

4.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.82

3.01

1.7

1.8

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.63

2.96

2.8

2.4

183.6

177.5

ng/l

0.02

(3037467) Urinalysis macro (dipstick) panel - Urine

654

2.01

2.89

3.4

4.3

—

(3002256) Pathology report gross observation

129

2.19

2.77

1.2

1.3

—

(3044889) 12 lead EKG panel

697

1.88

2.35

4.5

3.8

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.58

2.29

1.9

5.1

23.7

24.2

mmol/l

0.26

(3019198) Lymphocytes [#/volume] in Blood

509

1.74

2.23

7.0

5.7

1.8

e9/l

0.12

450

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

3.85

2.18

4.6

4.1

56.9

63.0

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

3.85

2.18

4.6

3.3

3.9

5.3

e9/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

591

1.75

2.17

8.2

9.7

4.1

e9/l

0.09

519

(3012544) pH of Venous blood

106

2.07

2.06

2.4

5.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

219

1.78

1.98

2.8

2.0

2.8

3.2

mg/l

0.40

195

(3001604) Monocytes [#/volume] in Blood

501

1.67

1.97

7.1

5.7

0.6

e9/l

0.43

438

(3006315) Basophils [#/volume] in Blood

501

1.67

1.97

7.1

5.7

0.0

e9/l

0.81

437

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

108

978

2.35

1.96

19.8

14.4

20.9

22.2

mg/l

0.21

771

(3002032) Base excess in Venous blood by calculation

101

2.05

1.94

2.4

5.3

1.4

2.1

mmol/l

0.44

(3013115) Eosinophils [#/volume] in Blood

516

1.64

1.85

7.3

5.9

0.2

e9/l

0.67

455

(40768804) Tissue Pathology biopsy report

412

1.63

1.82

2.3

2.0

—

(3045142) Bone marrow Pathology biopsy report

3.97

1.73

1.0

1.2

—

(3021589) Normoblasts [#/volume] in Blood

438

1.59

1.66

11.0

9.9

0.0

e9/l

0.49

357

(3020564) Creatinine [Moles/volume] in Serum or Plasma

111

1034

2.43

1.52

22.2

17.1

74.8

78.3

umol/l

0.87

111

1034

(40760888) Immunoglobulin light chains.free panel - Serum

2.82

1.45

5.8

7.5

—

(3021788) Differential panel - Synovial fluid

3.22

1.45

1.0

1.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

744

1.59

1.38

5.5

4.0

12.6

12.1

mm/h

0.12

673

(4034850)

0.00

1.37

0.0

8.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

155

1.69

1.37

1.9

1.8

—

(40761536) Microorganisms panel - Urine sediment

1.96

1.36

3.1

3.3

—

(3018095) Leukocytes [#/volume] in Urine

358

1.52

1.36

3.3

3.7

10.1

60.2

e6/l

2.45

247

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.58

1.32

1.3

1.2

—

(3000494) Fungus identified in Specimen by Culture

125

1.72

1.28

1.9

1.4

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

101

915

1.76

1.28

4.7

1.8

1.9

mu/l

0.90

823

(40758558) Short blood count panel - Blood

264

1.53

1.23

6.7

7.1

—

(3019060) Gas panel - Arterial blood

2.03

1.21

4.0

4.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.38

1.20

1.7

1.2

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

1.18

0.0

6.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

112

1.72

1.17

2.0

1.8

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.56

1.16

1.0

1.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

865

1.61

1.16

21.6

15.8

39.5

40.4

0.58

625

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

2.01

1.10

5.4

3.1

4.0

4.6

pmol/l

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

104

960

1.75

1.08

4.7

6.1

6.0

mmol/l

0.36

870

(3030467) Casts [#/volume] in Urine by Automated count

282

1.46

1.04

3.0

3.1

0.2

0.4

e6/l

1.20

200

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.99

0.0

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.85

0.98

1.6

—

(36304419) Bacteria [Presence] in Urine

267

1.44

0.97

3.1

3.0

—

(4010399)

1.75

0.96

1.5

1.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.29

0.95

1.5

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.69

0.92

1.7

—

(3002582) Erythrocytes [#/volume] in Urine

309

1.39

0.87

3.2

3.1

8.7

246.5

e6/l

0.58

232

(3017143) Hepatitis C virus Ab [Presence] in Serum

114

1.57

0.85

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

114

1.57

0.85

2.0

1.8

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.92

0.83

1.3

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

115

1.56

0.82

2.0

1.8

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.80

0.77

1.3

1.8

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.80

0.77

3.0

1.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

740

1.36

0.77

4.0

14.5

15.0

pmol/l

1.04

672

(3000492) Spirometry study

1.59

0.76

1.5

—

(3037756) Immunofixation for Serum or Plasma

2.13

0.75

1.6

1.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.63

0.73

1.0

1.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.96

0.71

1.2

1.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

111

1.51

0.70

2.4

3.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.63

0.68

3.8

2.9

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

1.82

0.67

4.2

2.6

216.6

207.3

—

(3003694) ABO and Rh group [Type] in Blood

247

1.35

0.66

1.5

1.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

167

1.39

0.63

2.3

2.9

4.2

1.6

e6/l

—

(3026782) Osmolality of Urine

195

1.36

0.61

2.5

2.9

480.6

536.4

mosm/kgh2o

0.95

166

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

223

1.34

0.60

2.5

1.9

0.8

1.4

mg/l

1.13

179

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.60

0.0

3.0

—

106.1

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.60

0.0

3.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.60

0.0

3.0

—

4.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

124

1.43

0.60

1.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

187

1.36

0.59

1.9

1.6

1239.3

1192.3

nmol/l

0.09

140

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.59

0.0

2.9

—

45.7

—

(3020891) Body temperature

1.75

0.58

5.7

4.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.57

0.56

1.6

1.5

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

108

1.45

0.56

2.8

4.8

2.2

10.7

ug/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

936

1.38

0.55

18.5

13.6

82.9

79.9

ml/min/173m2

0.76

767

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

372

0.77

0.55

3.3

3.7

—

(3045414) Leukocytes [Presence] in Urine

1.57

0.54

1.0

1.7

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

342

1.26

0.51

3.1

3.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

183

1.32

0.50

2.3

2.8

0.8

e6/l

0.05

100

(40761511) CBC panel - Blood by Automated count

107

1028

1.48

0.50

16.9

13.4

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

305

1.26

0.49

3.7

3.2

923.4

1085.3

ng/l

0.23

247

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

383

1.24

0.47

2.2

2.0

83.7

95.5

pmol/l

1.00

188

(3026008) Bacteria identified in Urine by Culture

290

1.24

0.44

2.5

3.0

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.64

0.43

1.4

2.1

—

(1761868) Lipid panel - Serum or Plasma

352

0.80

0.43

2.7

3.1

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.41

0.0

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.41

0.0

1.5

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.41

0.0

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.45

0.40

1.4

1.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

152

1.30

0.40

1.3

1.7

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.45

0.40

1.6

1.5

—

(3023520) Reticulocytes [#/volume] in Blood

1.39

0.39

2.1

2.9

82.8

73.4

e9/l

—

(3007164) IgA [Mass/volume] in Serum or Plasma

199

1.26

0.39

2.5

1.5

1.8

2.3

g/l

0.61

123

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

598

1.20

0.38

3.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

164

1.26

0.35

1.4

1.2

134.1

36.5

iu/ml

—

(3025941) Bacteria identified in Stool by Culture

1.40

0.32

1.1

1.5

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.34

0.31

3.1

5.0

23.4

25.2

mmol/l

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

149

1.25

0.30

1.2

0.8

8.5

u/ml

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

192

0.81

0.28

2.4

2.7

1.1

0.8

ug/l

0.27

123

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

160

1.22

0.27

1.8

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.22

0.25

1.3

1.6

—

(36660697) Celiac disease serology panel - Serum

1.22

0.25

1.0

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

272

0.85

0.24

2.3

3.4

—

(3049717) Cytology report of Urine Cyto stain

1.37

0.24

1.6

2.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.33

0.23

1.0

1.8

—

(3012516) Albumin [Mass/volume] in Urine

288

1.15

0.23

3.0

3.3

1924.4

55.6

mg/l

0.47

186

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

1.29

0.23

1.8

2.6

0.0

g/l

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

1.29

0.23

1.8

2.6

0.0

g/l

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

1.23

0.22

1.8

2.5

0.0

g/l

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.5

—

(4146454)

0.00

0.21

0.0

3.3

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.21

0.0

1.1

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.2

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3037522) Nuclear Ab [Titer] in Serum

127

1.21

0.21

1.3

1.4

240.0

408.0

titre

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.19

0.19

3.3

2.2

—

(40768797) Stomach Pathology biopsy report

138

1.18

0.18

1.3

—

(21494755) Public health laboratory ask at order entry panel

0.81

0.15

1.1

1.4

—

(3048689) Calprotectin [Mass/mass] in Stool

118

0.83

0.15

2.7

2.1

172.1

96.1

ug/g

—

103

(3021601) Nitrite [Presence] in Urine by Test strip

486

1.09

0.13

3.3

5.2

0.0

estimate

0.00

(3011397) Hemoglobin [Presence] in Urine by Test strip

222

1.10

0.11

2.8

3.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

217

0.91

0.10

6.8

5.7

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

1.14

0.10

3.4

1.8

231.6

364.9

ug/l

—

(3042936) Bacteria identified in Isolate by Culture

144

0.89

0.09

3.5

2.1

—

(3022145) Colonoscopy Study observation

117

1.13

0.08

1.3

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.12

0.08

1.9

1.1

211.6

133.5

u/ml

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

403

1.07

0.08

4.0

3.8

30.6

47.0

ng/l

0.41

291

(3017732) Neutrophils [#/volume] in Blood

1.03

0.08

2.0

2.3

3.4

3.9

e9/l

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

976

1.09

0.08

4.4

4.6

1.4

1.5

mmol/l

0.74

889

(40761535) Cells panel - Urine sediment

1.09

0.07

1.4

3.0

—

(3022621) pH of Urine by Test strip

1.09

0.07

1.6

2.4

—

(3035350) Ketones [Presence] in Urine by Test strip

486

0.94

0.07

2.7

3.6

0.0

estimate

0.00

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

132

0.90

0.07

1.3

1.5

—

(3013512) EKG study

314

0.94

0.06

3.1

4.2

—

(3029937) Albumin [Presence] in Urine by Test strip

248

1.06

0.05

3.5

3.4

0.0

estimate

0.00

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

1000

0.94

0.04

5.3

5.2

2.7

mmol/l

0.08

908

(3020682) Albumin/Creatinine [Ratio] in Urine

309

1.05

0.04

3.2

4.0

1.3

8.2

mg/mmol

3.13

193

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

940

1.06

0.04

3.9

4.2

1.3

mmol/l

0.18

851

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

123

1.06

0.02

12.1

7.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

254

1.03

0.00

4.4

25.0

22.4

—

122

(3009261) Glucose [Presence] in Urine by Test strip

492

0.99

0.00

2.7

3.6

0.0

estimate

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

983

0.98

0.00

4.6

4.7

4.6

mmol/l

0.17

902

(3042847) Granulocytes/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.6

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.2

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.4

—

14.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.94

0.00

4.8

5.0

44.5

50.1

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.97

0.00

1.4

1.8

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.8

—

(3020951) Lymphocytes/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.0

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.2

—

13.2

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

7.4

—

0.6

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

1.8

—

(3004451) EKG impression Narrative

0.00

0.0

1.1

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.1

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.4

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.99

0.00

1.4

1.7

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3012565) Volume of 24 hour Urine

0.00

0.0

1.5

—

2165.8

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

13.3

—

810.4

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

62.8

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

5.5

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

0.92

0.00

3.4

2.4

31.4

42.7

u/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.86

0.00

1.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.3

—

135.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

15.4

—

1399.9

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

0.0

1.0

—

147.3

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.1

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

9.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

6.0

—

(4027681)

0.00

0.0

1.1

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.4

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.4

—

(3019225) pH of Specimen

0.95

0.00

3.8

5.7

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

0.0

1.8

—

1.2

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.7

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.0

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.7

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.3

—

33.3

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(4198724)

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_MEDIASTINUM and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_MEDIASTINUM.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_MEDIASTINUM – Benign neoplasm: Mediastinum

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Mediastinum

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints