Metabolic disorder, other/unspecified

E4_METABONAS

metabolic disease: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E88.8#, E88.9#
  • Hospital discharge: ICD-9 277[8-9]
  • Cause of death: ICD-10 E88.8#, E88.9#
  • Cause of death: ICD-9 277[8-9]

2 out of 7 registries used, show all original rules.

109

4. Check minimum number of events

None

109

5. Include endpoints

None

109

6. Filter based on genotype QC (FinnGen only)

109

Control definitions (FinnGen only)

Control exclude
E4_METABOLIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1049 516 527
Only index persons 686 348 338
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 19.12 21.80 16.02
Only index persons 38.81 39.57 38.04

-FinnGen-

Key figures

All Female Male
Number of individuals 109 56 53
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 51.48 51.51 51.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
94
Matched controls
939
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E88.8
ICD-10 Finland
Other specified metabolic disorders
+∞
57.3
49
*
E88.9
ICD-10 Finland
Metabolic disorder, unspecified
+∞
54.6
47
*
E88.0
ICD-10 Finland
Disorders of plasma-protein metabolism, not elsewhere classified
+∞
26.3
24
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.0
12.3
59
236
L28
ICPC
Limited function/disability (L)
5.5
8.7
27
64
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
6.8
8.3
21
38
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
6.4
8.2
22
43
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
9.4
8.0
16
20
R5140
NOMESCO Finland
Monitoring the use of the aid
7.2
7.9
19
32
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.9
7.9
39
143
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
9.7
7.7
15
18
R06.0
ICD-10 Finland
Dyspnoea
4.1
7.5
33
110
G47.3
ICD-10 Finland
Sleep apnoea
4.3
7.5
30
92
G71.3
ICD-10 Finland
Mitochondrial myopathy, not elsewhere classified
+∞
7.4
7
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
10.1
7.4
14
16
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
6.7
7.2
18
32
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.9
7.2
24
61
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
15.3
7.1
11
8
TAB00
NOMESCO Finland
Lumbar puncture
10.6
7.0
13
14
JN3AD
NOMESCO Finland
Abdominal CT examination
8.3
7.0
15
21
EBA15
NOMESCO Finland
Extraction of large number of teeth
18.4
6.9
10
6
Z31.5
ICD-10 Finland
Genetic counselling
8.4
6.7
14
19
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.9
6.7
16
27
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.8
6.6
30
103
J45.9
ICD-10 Finland
Asthma, unspecified
4.0
6.5
27
85
JN3BD
NOMESCO Finland
Extensive abdominal CT
6.0
6.4
17
33
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
19.7
6.4
9
5
127
Kela drug reimbursment
Transplant complication
28.8
6.3
8
*
J01MA12
ATC
levofloxacin; systemic
4.0
6.3
26
81
Z94.4
ICD-10 Finland
Liver transplant status
+∞
6.3
6
*
R4110
NOMESCO Finland
Physiotherapy
3.4
6.2
35
139

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3027315) Oxygen [Partial pressure] in Blood
17
10
19.96
20.72
3.3
1.0
kpa
8.8
8.8
—
17
10
(3013290) Carbon dioxide [Partial pressure] in Blood
17
10
19.96
20.72
3.3
1.0
kpa
5.0
4.7
—
17
10
(3013742) Prealbumin [Mass/volume] in Serum or Plasma
37
82
6.32
17.21
4.9
3.5
g/l
0.2
0.2
0.94
32
76
(3032080) INR in Blood by Coagulation assay
70
270
5.45
17.10
9.5
6.4
inr
1.1
1.2
0.90
27
72
(3044290) Cell count panel - Cerebral spinal fluid
17
19
10.42
14.16
1.3
5.3
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
68
290
4.58
13.77
13.1
8.8
—
—
—
0
0
(3024561) Albumin [Mass/volume] in Serum or Plasma
71
324
4.42
12.84
10.0
5.6
g/l
34.6
36.1
1.08
65
303
(3013826) Glucose [Moles/volume] in Serum or Plasma
88
473
5.47
12.70
13.4
5.5
mmol/l
6.8
6.5
0.66
83
440
(1616796) Gas panel - Central venous blood
17
9
22.05
12.03
2.5
3.0
—
—
—
0
0
(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation
31
81
4.95
11.64
15.1
8.5
mmol/l
0.9
1.3
0.23
23
65
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
29
72
5.13
11.55
32.5
16.6
mmol/l
24.2
25.3
1.15
29
72
(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection
12
11
12.13
11.26
2.8
1.7
—
—
—
0
0
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
53
218
3.79
10.66
3.9
1.9
u/l
143.1
134.6
0.15
53
206
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
13
15
9.70
10.45
2.5
1.4
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
60
272
3.68
10.33
7.1
3.3
—
—
—
0
0
(3014111) Lactate [Moles/volume] in Serum or Plasma
28
74
4.75
10.28
23.4
9.1
mmol/l
1.5
1.3
0.67
28
68
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
26
65
4.94
10.20
6.6
3.1
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
48
193
3.66
9.85
8.9
4.3
—
—
—
0
0
(3002582) Erythrocytes [#/volume] in Urine
55
243
3.55
9.73
7.5
3.3
e6/l
21.0
291.4
0.50
47
183
(3030467) Casts [#/volume] in Urine by Automated count
52
224
3.53
9.53
7.4
3.3
e6/l
0.4
0.6
0.34
47
167
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
74
398
3.68
9.50
22.4
8.1
mmol/l
1.2
1.2
0.25
63
349
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
44
175
3.54
9.07
3.8
3.3
ng/l
929.2
805.5
0.15
38
140
(36304419) Bacteria [Presence] in Urine
51
224
3.40
8.96
7.2
3.2
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
59
288
3.29
8.63
8.8
3.7
e6/l
159.8
38.1
0.44
49
195
(3013115) Eosinophils [#/volume] in Blood
79
466
3.53
8.29
13.0
8.1
e9/l
0.2
0.2
0.70
69
412
(3001604) Monocytes [#/volume] in Blood
77
455
3.36
7.89
11.3
7.6
e9/l
0.6
0.5
1.76
67
394
(3006315) Basophils [#/volume] in Blood
77
456
3.35
7.84
11.4
7.6
e9/l
0.0
0.0
0.37
67
395
(3009508) Creatinine [Moles/volume] in Urine
49
225
3.14
7.78
4.8
2.9
mmol/l
6.4
8.4
1.80
43
193
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
12
18
7.37
7.78
2.7
1.8
—
—
—
0
0
(3028271) Lactate [Moles/volume] in Capillary blood
10
12
9.07
7.70
1.8
1.8
mmol/l
2.3
1.6
—
10
12
(3028026) IgM [Mass/volume] in Serum or Plasma
24
70
4.11
7.64
2.3
1.9
g/l
1.0
1.2
0.44
19
65
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
14
27
5.80
7.18
2.6
2.0
—
—
—
0
0
(3018418) pH of Serum or Plasma
47
219
3.01
7.17
7.3
3.2
ph
7.4
7.4
0.44
18
35
(3021589) Normoblasts [#/volume] in Blood
72
424
3.06
7.14
18.2
10.3
e9/l
0.0
0.0
0.63
60
336
(3000991) Gas panel - Venous blood
27
90
3.66
7.10
25.4
7.4
—
—
—
0
0
(3002032) Base excess in Venous blood by calculation
28
97
3.54
6.95
27.5
9.6
mmol/l
0.6
1.8
0.90
20
69
(3019198) Lymphocytes [#/volume] in Blood
77
475
3.12
6.95
11.4
7.6
e9/l
1.9
2.2
0.66
67
422
(3022313) Gas panel - Capillary blood
23
70
3.90
6.88
19.3
8.0
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
31
116
3.34
6.81
2.8
1.8
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
59
320
2.84
6.69
5.0
2.3
nmol/l
77.4
77.6
0.01
52
280
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
51
259
2.82
6.52
2.3
1.6
pmol/l
84.0
98.8
1.60
29
128
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
12
22
6.01
6.44
3.3
3.9
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
13
26
5.54
6.40
2.7
2.0
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
13
26
5.54
6.40
1.5
1.6
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
16
39
4.64
6.34
1.4
1.1
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
47
232
2.80
6.30
4.9
2.7
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
14
31
5.03
6.18
6.3
6.5
%
193.9
165.2
0.90
14
31
(3037522) Nuclear Ab [Titer] in Serum
29
113
3.13
5.90
1.5
1.5
titre
780.0
567.3
—
10
22
(3001122) Ferritin [Mass/volume] in Serum or Plasma
59
336
2.65
5.86
4.7
2.4
ug/l
166.5
103.7
0.97
52
302
(3007628) Bicarbonate [Moles/volume] standard in Venous blood
21
67
3.64
5.83
35.3
12.4
mmol/l
23.2
24.0
0.65
21
61
(3021901) Oxygen saturation in Capillary blood
10
17
6.38
5.74
3.8
2.0
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
41
197
2.73
5.69
4.7
3.4
mg/mmol
9.2
8.8
0.03
24
117
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
15
38
4.42
5.65
5.8
5.9
%
83.3
90.2
0.38
15
38
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
12
25
5.27
5.64
1.5
1.6
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
12
25
5.27
5.64
1.9
1.7
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
79
529
2.79
5.52
15.6
11.0
e9/l
4.0
3.8
0.27
68
465
(3022806) Fractional oxyhemoglobin in Capillary blood
8
5
17.09
5.50
2.0
3.6
%
93.4
92.2
—
8
5
(3006653) Thiamine [Moles/volume] in Blood
8
5
17.09
5.50
1.1
1.0
nmol/l
129.5
160.8
—
8
5
(40761536) Microorganisms panel - Urine sediment
21
70
3.48
5.45
6.0
3.2
—
—
—
0
0
(3034770) Mitochondria Ab [Titer] in Serum
12
26
5.06
5.40
1.5
1.3
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
25
95
3.12
5.27
1.3
1.2
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
26
103
3.00
5.10
1.8
1.4
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
49
269
2.49
5.08
5.8
3.1
ng/l
23.3
42.4
0.59
44
163
(3026008) Bacteria identified in Urine by Culture
40
201
2.56
4.98
3.7
2.4
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
15
42
3.98
4.96
2.1
1.5
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
38
187
2.58
4.94
3.9
2.8
mg/l
38.9
53.4
0.28
28
119
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
30
132
2.76
4.85
5.9
3.3
e6/l
2.8
2.6
0.04
19
79
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
91
682
3.02
4.66
4.1
3.6
pmol/l
14.6
14.8
0.38
85
620
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
27
115
2.79
4.62
1.7
1.7
pmol/l
481.7
477.0
0.02
21
100
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
35
172
2.52
4.51
5.2
2.7
—
—
—
0
0
(3017181) Myelocytes/100 leukocytes in Blood
19
67
3.22
4.49
4.9
7.5
%
1.1
0.8
—
9
26
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
58
358
2.33
4.49
6.9
4.3
—
—
—
0
0
(3025159) Blasts/100 leukocytes in Blood
18
62
3.28
4.42
5.0
7.8
%
0.1
0.0
—
9
22
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
10
22
4.90
4.40
1.6
1.5
—
—
—
0
0
(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma
15
46
3.62
4.37
8.8
2.6
ng/l
410.9
150.5
0.55
15
41
(40760888) Immunoglobulin light chains.free panel - Serum
8
9
9.48
4.36
4.1
8.8
—
—
—
0
0
(40768441) Liver Pathology biopsy report
7
6
12.34
4.34
1.7
1.3
—
—
—
0
0
(3013707) Erythrocyte sedimentation rate by Westergren method
86
638
2.65
4.28
7.5
3.7
mm/h
16.6
10.2
2.45
86
582
(3030905) Polymorphonuclear cells [#/volume] in Blood
8
10
8.52
4.13
4.0
4.0
e9/l
3.0
4.1
—
8
10
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
8
10
8.52
4.13
5.5
5.7
%
51.5
53.3
—
8
10
(3002179) Metamyelocytes/100 leukocytes in Blood
17
59
3.23
4.11
4.5
7.8
%
0.6
0.3
—
8
18
(3021440) Promyelocytes/100 leukocytes in Blood
18
65
3.12
4.09
5.1
7.7
%
0.1
0.2
—
9
25
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
9
14
6.90
4.07
2.1
1.4
—
—
—
0
0
(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection
7
7
10.57
4.07
2.6
1.3
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
77
553
2.34
3.96
8.3
3.6
—
—
—
0
0
(3023103) Potassium [Moles/volume] in Serum or Plasma
104
897
4.47
3.91
39.1
13.1
mmol/l
4.0
4.0
0.47
104
873
(3019550) Sodium [Moles/volume] in Serum or Plasma
104
895
4.53
3.91
38.3
13.1
mmol/l
139.0
139.7
2.10
104
872
(3007853) Bacteria identified in Skin by Aerobe culture
23
98
2.71
3.90
2.0
1.6
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
13
39
3.65
3.90
3.6
1.7
—
—
—
0
0
(3044889) 12 lead EKG panel
76
549
2.27
3.76
5.0
3.4
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
13
40
3.55
3.76
1.9
1.5
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
100
844
3.24
3.69
32.7
13.1
%
38.1
40.2
1.45
78
659
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
9
17
5.66
3.59
2.1
1.8
—
—
—
0
0
(3022756) Ceruloplasmin [Mass/volume] in Serum or Plasma
6
6
10.48
3.54
1.7
1.0
mg/l
229.0
288.3
—
6
6
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
95
767
2.86
3.51
24.8
10.2
ml/min/173m2
84.4
86.8
0.39
85
613
(3009261) Glucose [Presence] in Urine by Test strip
60
403
2.09
3.48
6.6
3.1
estimate
0.0
0.0
0.00
20
73
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
10
27
3.98
3.44
2.2
2.3
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
7
10
7.39
3.42
2.4
1.1
—
—
—
0
0
(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay
7
10
7.39
3.42
1.3
1.5
—
—
—
0
0
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
28
140
2.35
3.40
5.9
3.1
e6/l
0.5
0.8
0.81
18
87
(3035350) Ketones [Presence] in Urine by Test strip
59
398
2.05
3.34
6.7
3.1
estimate
0.0
0.0
0.00
22
78
(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing
6
7
8.98
3.30
1.0
1.0
—
—
—
0
0
(3007164) IgA [Mass/volume] in Serum or Plasma
38
221
2.10
3.18
3.0
1.5
g/l
2.7
2.1
0.61
27
121
(3025941) Bacteria identified in Stool by Culture
11
34
3.49
3.15
1.2
1.3
—
—
—
0
0
(3042631) Mycobacterium sp identified in Specimen
6
8
7.85
3.09
4.2
1.5
—
—
—
0
0
(3016914) Bacteria identified in Cerebral spinal fluid by Culture
6
8
7.85
3.09
1.2
1.5
—
—
—
0
0
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
6
8
7.85
3.09
3.0
1.8
g/l
1.2
0.9
—
6
8
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
9
21
4.57
3.07
1.1
1.2
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
20
90
2.50
3.02
3.0
1.6
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
25
125
2.30
3.01
2.6
1.9
—
—
—
0
0
(3035999) Lactate [Moles/volume] in Cerebral spinal fluid
5
5
10.39
3.01
1.0
1.8
mmol/l
1.6
1.4
—
5
5
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
8
17
4.99
2.98
1.6
1.8
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
37
218
2.06
2.97
6.6
2.7
—
—
—
0
0
(4035726)
16
65
2.71
2.95
1.4
1.5
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
22
106
2.35
2.88
3.0
1.4
nmol/l
1599.1
1374.9
0.43
17
87
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
94
779
2.50
2.85
5.0
3.5
mmol/l
1.6
1.3
2.73
89
718
(3021601) Nitrite [Presence] in Urine by Test strip
57
396
1.92
2.82
9.4
4.2
estimate
0.0
0.0
0.00
23
79
(3022145) Colonoscopy Study observation
20
93
2.41
2.82
1.3
1.3
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
20
93
2.41
2.82
2.9
1.6
—
—
—
0
0
(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid
5
6
8.65
2.77
1.0
1.0
—
—
—
0
0
(3020393) Adenovirus Ag [Presence] in Stool
5
6
8.65
2.77
1.8
1.8
—
—
—
0
0
(3014007) Fractional oxyhemoglobin in Arterial blood
12
43
3.01
2.74
16.7
6.6
%
96.0
93.5
1.34
12
43
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
11
38
3.11
2.67
2.6
2.2
—
—
—
0
0
(3016650) Hepatitis A virus Ab [Presence] in Serum
7
15
4.91
2.64
1.0
1.1
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
36
219
1.96
2.60
1.9
1.6
mmol/l
2.3
1.3
0.89
31
181
(3004616) Nuclear Ab [Presence] in Serum
6
11
5.70
2.58
1.5
1.2
—
—
—
0
0
(3048689) Calprotectin [Mass/mass] in Stool
25
134
2.12
2.53
2.0
2.7
ug/g
173.2
82.3
1.02
18
105
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
25
134
2.12
2.53
4.2
2.6
ng/l
383.1
294.8
0.12
19
94
(3013512) EKG study
34
205
1.96
2.51
6.6
3.0
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
93
784
2.27
2.42
6.1
3.9
mmol/l
6.1
5.8
1.60
86
715
(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid
5
8
6.48
2.39
1.0
1.0
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
13
53
2.65
2.38
2.4
1.7
—
—
—
0
0
(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
104
937
3.39
2.37
20.9
9.4
u/l
35.2
27.0
2.47
104
904
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
9
28
3.41
2.37
1.1
1.3
—
—
—
0
0
(3045142) Bone marrow Pathology biopsy report
6
13
4.81
2.30
1.3
1.8
—
—
—
0
0
(3023410) Appearance of Cerebral spinal fluid
7
18
4.08
2.29
1.1
5.5
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
7
18
4.08
2.29
2.6
1.8
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
91
767
2.13
2.27
8.8
4.4
mmol/mol
42.0
38.6
2.03
83
717
(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay
5
9
5.76
2.23
7.2
1.1
%
85.6
108.2
—
5
9
(3002256) Pathology report gross observation
20
103
2.15
2.23
1.2
1.2
—
—
—
0
0
(3000492) Spirometry study
16
75
2.33
2.21
1.4
1.4
—
—
—
0
0
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
7
19
3.86
2.19
2.9
3.6
u/ml
3.6
4.5
—
7
19
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
7
19
3.86
2.19
3.0
2.4
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
5
10
5.18
2.09
2.4
2.0
—
—
—
0
0
(21494434) Karyotype in Bone marrow
5
10
5.18
2.09
1.2
1.4
—
—
—
0
0
(4062490)
5
10
5.18
2.09
1.2
1.3
—
—
—
0
0
(44790049)
7
20
3.67
2.09
3.0
1.9
—
—
—
0
0
(44806118)
7
20
3.67
2.09
3.0
1.9
—
—
—
0
0
(44790047)
7
20
3.67
2.09
3.0
1.9
—
—
—
0
0
(44790048)
7
20
3.67
2.09
3.0
1.9
—
—
—
0
0
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
35
228
1.79
1.99
1.3
1.6
u/ml
0.8
1.9
—
8
49
(40760892) CBC W Ordered Manual Differential panel - Blood
32
203
1.82
1.99
5.6
4.7
—
—
—
0
0
(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence
5
11
4.71
1.96
1.6
1.5
—
—
—
0
0
(3032773) Endomysium IgG Ab [Titer] in Serum
5
11
4.71
1.96
1.0
1.0
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
99
877
2.40
1.93
32.6
11.9
mg/l
19.8
22.9
0.61
90
648
(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection
6
17
3.67
1.86
1.8
1.7
—
—
—
0
0
(3019225) pH of Specimen
13
60
2.32
1.86
5.5
3.6
—
—
—
0
0
(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum
5
12
4.31
1.84
3.0
3.3
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
42
296
1.68
1.79
4.2
2.4
—
—
—
0
0
(40758558) Short blood count panel - Blood
35
235
1.72
1.78
10.7
8.2
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
93
813
1.98
1.75
5.8
3.8
mmol/l
1.3
1.5
2.30
87
750
(3016018) Differential panel - Cerebral spinal fluid
5
14
3.69
1.63
1.6
4.2
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
102
937
2.38
1.59
26.2
10.0
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
15
79
2.04
1.58
1.8
1.6
—
—
—
0
0
(4010399)
12
58
2.20
1.56
1.6
1.5
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
21
126
1.83
1.54
1.9
1.6
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
6
21
2.96
1.53
3.2
2.2
—
—
—
0
0
(3013327) Hepatitis A virus IgM Ab [Presence] in Serum
5
16
3.22
1.45
1.2
1.0
—
—
—
0
0
(3019230) Fractional oxyhemoglobin in Venous blood
5
16
3.22
1.45
67.6
23.2
%
57.7
65.7
—
5
16
(3011397) Hemoglobin [Presence] in Urine by Test strip
27
178
1.69
1.45
5.7
3.3
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
23
147
1.72
1.37
1.8
1.7
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
5
17
3.03
1.37
67.6
25.6
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
5
18
2.86
1.30
1.4
1.3
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
8
36
2.32
1.27
21.8
6.8
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
41
309
1.52
1.26
7.2
3.1
—
—
—
0
0
(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum
5
19
2.71
1.23
1.0
1.1
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
6
26
2.38
1.20
2.0
1.2
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
6
26
2.38
1.20
5.8
1.6
—
—
—
0
0
(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma
12
65
1.95
1.19
2.3
4.5
ug/l
8.8
74.8
—
7
49
(3001019) Free T4 and TSH panel - Serum or Plasma
7
30
2.42
1.14
1.3
1.2
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
31
227
1.51
1.07
7.8
3.3
estimate
0.0
0.0
0.00
21
74
(3021879) Hepatitis B virus core Ab [Presence] in Serum
12
69
1.83
1.01
1.9
1.5
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
32
239
1.48
1.00
2.0
1.5
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
18
118
1.63
0.98
1.8
1.7
—
—
—
0
0
(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma
7
37
1.95
0.96
1.9
4.0
u/ml
20.5
26.3
—
7
37
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
6
28
2.21
0.93
1.2
2.3
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
6
29
2.13
0.91
5.5
3.0
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
25
0.00
0.80
0.0
1.2
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
0
27
0.00
0.78
0.0
1.2
—
—
—
0
0
(4034850)
0
27
0.00
0.78
0.0
12.9
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
72
643
1.35
0.74
3.0
3.4
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
14
201
0.65
0.73
2.9
4.8
%
19.5
21.9
—
8
96
(3024891) Influenza virus A+B Ag [Presence] in Specimen
5
26
1.97
0.71
1.0
1.2
—
—
—
0
0
(3019060) Gas panel - Arterial blood
7
42
1.71
0.70
2.7
4.5
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
5
30
1.70
0.62
1.0
1.3
—
—
—
0
0
(40768800) Prostate Pathology biopsy report
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
(3022621) pH of Urine by Test strip
8
54
1.52
0.59
1.6
2.1
—
—
—
0
0
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
6
38
1.61
0.55
6.5
2.6
%
43.3
56.5
—
6
38
(46235355) HIV 1 and 2 tests - Meaningful Use set
24
190
1.34
0.54
1.8
2.0
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
7
45
1.59
0.50
1.1
1.2
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
9
129
0.67
0.46
1.1
1.5
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
24
195
1.30
0.46
1.8
1.7
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
6
93
0.62
0.44
1.3
1.4
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
5
33
1.54
0.42
2.0
1.7
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
5
34
1.49
0.41
1.0
1.1
—
—
—
0
0
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
18
0.00
0.40
0.0
1.5
—
—
—
0
0
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
6
41
1.49
0.36
57.7
10.3
%
1.2
1.6
—
6
41
(3003338) MCHC [Mass/volume]
84
797
1.24
0.36
31.2
15.6
g/l
334.1
334.2
0.03
84
792
(3017446) Testosterone [Moles/volume] in Serum or Plasma
12
91
1.36
0.35
3.7
2.3
nmol/l
12.4
14.7
—
7
84
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
17
141
1.24
0.28
1.4
1.2
u/ml
1.3
4.0
—
5
55
(1001926) Buprenorphine [Presence] in Urine by Screen method
5
37
1.37
0.24
4.0
1.4
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
7
95
0.72
0.23
7.6
6.8
—
—
—
0
0
(3019897) Erythrocyte distribution width [Ratio] by Automated count
0
11
0.00
0.21
0.0
1.9
—
13.8
—
0
11
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
11
0.00
0.21
0.0
2.1
—
13.8
—
0
11
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
(40765089) Chromosome analysis panel - Blood by G-banded
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(3035933) Granulocytes/100 leukocytes in Blood
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(3044941) Cell count panel - Synovial fluid
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
6
50
1.21
0.20
1.2
1.0
—
—
—
0
0
(40761535) Cells panel - Urine sediment
7
57
1.24
0.19
3.6
3.6
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
7
86
0.80
0.15
1.1
1.7
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
5
45
1.12
0.10
4.0
1.4
—
—
—
0
0
(3000764) Benzodiazepines [Presence] in Urine
5
47
1.07
0.09
4.0
1.4
—
—
—
0
0
(3027008) Opiates [Presence] in Urine
5
48
1.04
0.09
4.0
1.4
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
5
48
1.04
0.09
4.0
1.4
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
5
48
1.04
0.09
3.8
1.4
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
12
134
0.88
0.09
1.9
2.4
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
5
63
0.78
0.08
1.2
1.5
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
32
304
1.07
0.08
2.0
1.9
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
6
74
0.80
0.08
1.2
2.2
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
10
89
1.14
0.07
1.6
1.2
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
9
101
0.88
0.06
1.7
1.8
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
12
127
0.94
0.02
1.8
2.2
—
—
—
0
0
(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
4.7
—
0.5
—
0
7
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(3012565) Volume of 24 hour Urine
0
5
0.00
0.00
0.0
1.4
—
2359.0
—
0
5
(40759836) Histone Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3025130) Human papilloma virus identified in Specimen
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.1
—
0.3
—
0
7
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3032352) Blasts [#/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
7.6
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
6
65
0.92
0.00
1.0
1.0
—
—
—
0
0
(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3018993) Complement total hemolytic CH100 [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(36304052) Adalimumab Ab [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3041806) Other cells [#/volume] in Blood by Manual count
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011363) Streptococcus pneumoniae Ag [Presence] in Urine
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3026470) Cobalt [Mass/volume] in Blood
0
5
0.00
0.00
0.0
2.4
—
3.6
—
0
5
(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.6
—
5.6
—
0
7
(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
1860.6
—
0
5
(3053028) Streptococcus sp identified in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008832) Norclozapine [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
9.6
—
546.4
—
0
7
(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
95.2
—
0
5
(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
2.9
—
43.9
—
0
7
(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3005082) Progesterone [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
26.8
—
0
6
(3013727) Leukocytes other/100 leukocytes in Blood
0
6
0.00
0.00
0.0
10.7
—
38.5
—
0
6
(3042975) Streptococcus sp identified in Isolate by Organism specific culture
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000081) cloZAPine [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
12.7
—
1105.3
—
0
7
(3011436) Histone Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(1617658) Protocol used for examination of sentinel lymph nodes
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016031) Almond IgE Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
3.5
—
0
5
(3020491) Glucose [Moles/volume] in Blood
0
5
0.00
0.00
0.0
3.0
—
6.9
—
0
5
(3035320) C reactive protein [Mass/volume] in Body fluid
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3017315) Amylase [Enzymatic activity/volume] in Urine
0
9
0.00
0.00
0.0
1.3
—
405.6
—
0
9
(3020650) Glucose [Presence] in Urine
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3003329) Lymphocytes/100 leukocytes in Synovial fluid
0
5
0.00
0.00
0.0
1.2
—
17.4
—
0
5

Mortality – FinRegistry

Association

Association between endpoint E4_METABONAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_METABONAS 3.691 [2.35, 5.8] < 0.001
Birth year 0.995 [0.99, 1.0] 0.251

During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 330 females with E4_METABONAS died.

Males

Parameter HR [95% CI] p-value
E4_METABONAS 4.79 [3.22, 7.12] < 0.001
Birth year 0.984 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 316 males with E4_METABONAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_METABONAS.

N-year risk Females Males
1 0.407% 0.844%
5 2.113% 5.355%
10 5.119% 12.316%
15 10.336% 21.695%
20 17.406% 33.78%

Relationships between endpoints

Index endpoint: E4_METABONAS – Metabolic disorder, other/unspecified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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