Sequelae of inflammatory diseases of the central nervous system

G6_NEUROINFSEQ

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G09 Hospital discharge: ICD-9 — 326 Hospital discharge: ICD-8 — 324 Cause of death: ICD-10 — G09 Cause of death: ICD-9 — 326 Cause of death: ICD-8 — 324 2 out of 7 registries used, show all original rules.	110
4. Check minimum number of events None	110
5. Include endpoints None	110
6. Filter based on genotype QC (FinnGen only)	110

Control definitions (FinnGen only)

Control exclude: G6_NEUINFL

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G00-G09
Name in latin: Sequelae morborum inflammatoriorum systematis nervosi centralis

NAME	G6_NEUROINFSEQ
CONTROL_EXCLUDE	G6_NEUINFL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G09
HD_ICD_9	326
HD_ICD_8	324
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G09
COD_ICD_9	326
COD_ICD_8	324
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Sequelae of inflammatory diseases of the central nervous system based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1421	653	746
Only index persons	880	437	443
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	43.55	45.47	41.45
Only index persons	36.06	39.65	32.52

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	110	56	54
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	38.41	32.54	44.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
97: Matched controls
969

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G09

ICD-10 Finland

Sequelae of inflammatory diseases of central nervous system

+∞

59.7

32400

ICD-8 Finland

Late effects of intracranial abscess or pyogenic infection, Hydrocephalus acquisitus

+∞

20.5

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

14.1

14.0

A86

ICD-10 Finland

Unspecified viral encephalitis

+∞

10.6

G40.29

ICD-10 Finland

Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures

30.6

8.7

N03AF01

ATC

carbamazepine; oral, rectal

8.2

8.6

XA800

NOMESCO Finland

Neuropsychological investigation

11.5

7.8

G40.22

ICD-10 Finland

Complex partial epileptic seizure with secondary generalization

27.5

7.7

TAB00

NOMESCO Finland

Lumbar puncture

10.7

7.6

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

17.5

7.4

32401

ICD-8 Finland

Late effects of intracranial abscess or pyogenic infection, Status postencephaliticus

+∞

7.4

R51.80

ICD-10 Finland

Headache

4.4

6.7

N03AX14

ATC

levetiracetam; systemic

15.7

6.6

R4150

NOMESCO Finland

Neuropsychological rehabilitation

74.5

6.5

G06.0

ICD-10 Finland

Intracranial abscess and granuloma

+∞

6.3

2133

FHL

Suntin revisio

+∞

6.3

32408

ICD-8 Finland

Late effects of intracranial abscess or pyogenic infection, Alia definitae

+∞

6.3

G40.9

ICD-10 Finland

Epilepsy, unspecified

8.2

6.2

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044290) Cell count panel - Cerebral spinal fluid

6.68

6.56

3.3

1.1

—

(4027681)

13.84

5.69

1.3

1.1

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

12.11

5.39

1.2

1.0

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

5.20

5.13

3.9

1.1

110.5

123.4

e6/l

0.04

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

5.20

5.13

3.5

1.0

454.7

2.9

e6/l

0.48

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

10.76

5.13

1.2

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

12.19

4.86

1.3

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

8.52

4.13

1.5

1.0

—

(4062490)

9.24

3.83

1.1

1.0

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

12.58

3.81

1.3

1.0

—

(3019309) Folate [Moles/volume] in Red Blood Cells

146

2.34

3.46

1.7

1404.0

1204.9

nmol/l

0.67

112

(42870588) Differential panel, method unspecified - Blood

290

2.01

3.08

7.2

5.3

—

(3006315) Basophils [#/volume] in Blood

439

1.94

2.92

8.5

5.4

0.0

e9/l

0.04

393

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

8.65

2.77

1.0

1.2

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

8.65

2.77

1.4

1.0

—

(3003396) Base excess in Arterial blood by calculation

2.43

2.77

3.5

8.0

1.0

1.1

mmol/l

0.03

(3032080) INR in Blood by Coagulation assay

343

1.91

2.76

6.7

7.8

1.2

inr

0.30

104

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

6.27

2.73

1.2

1.1

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

2.60

2.59

1.4

1.3

—

51.3

—

(3019198) Lymphocytes [#/volume] in Blood

451

1.86

2.58

8.7

5.4

1.9

1.8

e9/l

0.54

408

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

7.41

2.57

1.0

—

(40761535) Cells panel - Urine sediment

2.67

2.57

2.6

3.7

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

3.54

2.45

1.4

1.0

—

(3001604) Monocytes [#/volume] in Blood

440

1.80

2.36

8.8

5.3

0.6

e9/l

0.76

393

(3023511) Choriogonadotropin [Units/volume] in Urine

4.08

2.29

1.9

1.3

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

155

1.98

2.27

2.3

2.7

2.5

mmol/l

0.45

136

(3013115) Eosinophils [#/volume] in Blood

457

1.75

2.17

11.0

5.8

0.2

e9/l

0.47

410

(3000330) Specific gravity of Urine by Test strip

2.87

2.17

9.1

3.7

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.24

2.15

2.8

1.7

276.2

388.1

nmol/l

2.65

(3037467) Urinalysis macro (dipstick) panel - Urine

599

1.79

2.11

7.1

4.0

—

(3042936) Bacteria identified in Isolate by Culture

115

2.02

2.00

1.4

2.0

—

(3026008) Bacteria identified in Urine by Culture

245

1.77

1.99

4.9

3.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

108

2.04

1.98

2.2

1.5

—

(3000494) Fungus identified in Specimen by Culture

108

2.04

1.98

1.8

1.5

—

(3031040) Bacteria [#/volume] in Urine by Automated count

566

1.72

1.93

5.7

4.1

—

52.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.07

1.89

8.2

6.8

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

520

1.67

1.84

13.6

9.9

4.5

4.3

e9/l

0.28

463

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.18

1.83

1.6

1.3

—

(3008037) Lactate [Moles/volume] in Venous blood

3.46

1.77

3.7

2.9

2.0

1.2

mmol/l

—

(3038515) Glucose [Moles/volume] in Venous blood

3.46

1.77

3.7

2.9

7.0

6.5

mmol/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.09

1.75

1.5

1.7

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

3.97

1.73

1.6

1.5

—

(3035285) Chloride [Moles/volume] in Venous blood

3.97

1.73

3.4

2.7

106.0

107.8

mmol/l

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

3.97

1.73

2.2

1.4

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

3.97

1.73

3.4

2.7

—

(3041354) Potassium [Moles/volume] in Venous blood

3.97

1.73

3.4

2.7

4.2

3.8

mmol/l

—

(3023368) Bacteria identified in Blood by Culture

229

1.70

4.6

4.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.21

1.67

1.7

1.3

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

3.69

1.63

1.0

1.1

—

(3023410) Appearance of Cerebral spinal fluid

3.69

1.63

1.8

1.1

—

(3028707) Methadone [Presence] in Urine by Screen method

3.69

1.63

2.0

1.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

416

1.59

1.57

8.5

7.0

1.2

mmol/l

0.60

357

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

134

1.80

1.54

1.7

2.0

—

(40768804) Tissue Pathology biopsy report

355

1.57

1.46

2.1

2.0

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

3.22

1.45

1.6

1.2

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.22

1.45

1.0

1.8

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.22

1.45

1.0

1.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

187

1.67

1.43

3.7

3.5

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.30

1.41

3.0

2.1

—

(40760888) Immunoglobulin light chains.free panel - Serum

3.03

1.37

6.6

5.9

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.96

1.37

3.6

2.6

10.8

13.4

nmol/l

0.89

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

251

1.58

1.34

2.9

3.0

808.0

1045.6

ng/l

0.19

210

(3021589) Normoblasts [#/volume] in Blood

370

1.53

1.34

11.5

10.0

0.0

e9/l

0.50

306

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.19

1.34

1.6

1.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.11

1.32

4.2

3.6

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.46

1.32

2.4

2.5

—

(3027008) Opiates [Presence] in Urine

2.25

1.24

1.6

1.4

—

(3028300) Cannabinoids [Presence] in Urine

2.25

1.24

1.6

1.4

—

(3000764) Benzodiazepines [Presence] in Urine

2.25

1.24

1.6

1.4

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

2.25

1.24

1.8

39.6

33.4

nmol/l

—

(3035350) Ketones [Presence] in Urine by Test strip

423

1.49

1.23

5.0

3.5

0.0

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

423

1.49

1.23

7.4

4.9

0.0

estimate

0.00

(1761868) Lipid panel - Serum or Plasma

329

0.62

1.21

3.1

2.9

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.19

1.21

1.5

2.3

—

(3027944) Amphetamines [Presence] in Urine

2.19

1.21

1.6

1.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

128

1.69

1.19

2.6

1.7

3.2

e6/l

0.52

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.82

1.18

1.5

1.8

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.13

1.18

3.4

3.5

27.0

24.6

mmol/l

—

(3028026) IgM [Mass/volume] in Serum or Plasma

2.00

1.17

3.8

1.4

1.7

1.1

g/l

0.30

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.89

1.16

3.0

2.5

0.2

g/l

0.79

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

877

0.65

1.16

4.3

4.2

1.5

1.4

mmol/l

0.07

819

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.57

1.16

1.0

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.79

1.14

1.4

1.8

—

(3045414) Leukocytes [Presence] in Urine

2.34

1.12

1.6

1.5

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.34

1.12

1.7

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.44

1.10

1.2

—

(3012544) pH of Venous blood

1.89

1.09

3.7

3.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.20

1.07

2.0

2.9

—

(40758558) Short blood count panel - Blood

209

1.53

1.07

12.0

7.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

300

1.46

1.06

3.9

2.9

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

881

0.66

1.05

4.3

4.7

mmol/l

0.02

828

(3029937) Albumin [Presence] in Urine by Test strip

219

1.51

1.05

3.4

3.8

0.0

estimate

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.13

1.05

3.9

2.5

3.5

1.2

—

(3052851) Hemolysis interference index of Serum or Plasma

2.33

1.04

4.0

2.9

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.33

1.04

17.2

5.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

108

1.68

1.04

2.2

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

898

0.66

1.03

4.6

4.8

2.8

mmol/l

0.13

841

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.07

1.02

4.0

3.0

45.0

51.8

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.91

1.01

1.0

1.2

126.8

144.2

u/ml

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

340

1.43

1.01

3.7

3.6

27.9

49.9

ng/l

0.70

229

(3016879) Cocaine [Presence] in Urine

2.01

0.99

1.7

1.4

—

(3009261) Glucose [Presence] in Urine by Test strip

429

1.40

0.95

5.0

3.6

0.0

estimate

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

847

0.70

0.90

3.9

1.4

1.3

mmol/l

0.24

790

(4035726)

1.71

0.89

1.4

1.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

328

1.40

0.88

5.3

3.6

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.99

0.86

2.8

1.1

—

(3044640) Blood type and Crossmatch panel - Blood

275

1.40

0.83

2.9

2.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

141

1.51

0.82

2.6

2.4

0.9

1.1

e6/l

0.08

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.80

0.0

1.3

—

(3037522) Nuclear Ab [Titer] in Serum

125

1.53

0.79

1.5

1.4

464.0

402.2

titre

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.78

0.0

1.4

—

191.9

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.81

0.77

1.8

2.1

—

(21494755) Public health laboratory ask at order entry panel

109

0.52

0.77

1.0

1.3

—

(3019060) Gas panel - Arterial blood

1.69

0.76

3.9

4.1

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.13

0.75

1.0

1.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

2.13

0.75

1.2

1.3

—

(3044889) 12 lead EKG panel

629

0.75

3.3

3.7

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.05

0.73

1.8

4.8

0.0

g/l

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.80

0.73

1.6

1.7

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

300

1.35

0.72

3.1

2.7

29.4

31.3

u/l

0.20

283

(3020891) Body temperature

1.97

0.71

3.8

2.9

—

(3013512) EKG study

245

1.37

0.70

4.3

3.8

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

174

1.41

0.67

5.2

2.9

21.1

111.3

ng/l

1.12

131

(3022948) Iron [Moles/volume] in Serum or Plasma

139

1.44

0.66

2.7

2.3

10.6

14.0

umol/l

0.62

128

(3015377) Calcium [Moles/volume] in Serum or Plasma

305

1.32

0.64

2.7

3.4

2.4

mmol/l

0.08

267

(40761536) Microorganisms panel - Urine sediment

1.59

0.58

5.1

3.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

179

1.36

0.57

1.9

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

396

1.28

0.57

5.3

3.7

—

(3022621) pH of Urine by Test strip

1.52

0.55

2.6

2.2

—

(3000991) Gas panel - Venous blood

1.47

0.54

3.0

7.0

—

(3017181) Myelocytes/100 leukocytes in Blood

1.52

0.53

6.8

4.2

1.4

0.8

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.53

0.52

5.5

7.5

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.54

0.51

4.3

3.7

62.7

67.6

g/l

—

(40768797) Stomach Pathology biopsy report

128

1.39

0.51

1.1

1.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.61

0.44

2.0

1.5

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

819

0.80

0.44

6.1

5.4

39.9

39.4

mmol/mol

0.26

775

(3021440) Promyelocytes/100 leukocytes in Blood

1.47

0.43

7.3

4.3

0.1

0.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.59

0.43

1.6

1.4

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.59

0.43

1.8

4.1

3.1

3.3

g/l

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.54

0.42

1.8

4.0

3.5

3.6

g/l

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.54

0.42

8.2

1.9

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.54

0.42

1.8

4.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

133

1.33

0.41

2.0

1.5

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.39

0.0

2.6

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

126

1.32

0.38

1.4

1.8

1.4

1.5

0.08

108

(3019150) Specific gravity of Urine by Refractometry

191

1.26

0.37

4.6

3.7

1.0

kg/l

—

(36304419) Bacteria [Presence] in Urine

240

1.22

0.35

3.9

2.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

193

1.24

0.34

2.6

1.3

2.3

2.5

g/l

0.31

122

(3004789) Transferrin [Mass/volume] in Serum or Plasma

128

1.29

0.34

2.8

2.3

2.4

g/l

0.22

112

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

327

1.20

0.34

2.0

93.6

98.6

pmol/l

0.28

163

(3003458) Phosphate [Moles/volume] in Serum or Plasma

101

1.33

0.33

11.9

5.7

0.9

1.0

mmol/l

0.51

(3030467) Casts [#/volume] in Urine by Automated count

242

1.21

0.32

4.4

2.8

0.1

0.3

e6/l

0.93

170

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.40

0.32

1.4

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

895

1.25

0.31

25.5

13.5

19.9

22.3

mg/l

0.38

714

(3018418) pH of Serum or Plasma

262

1.20

0.31

7.5

3.9

7.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

208

1.20

0.27

8.8

4.6

—

(3002582) Erythrocytes [#/volume] in Urine

266

1.18

0.26

4.2

2.9

219.4

272.8

e6/l

0.06

193

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.71

0.25

1.7

1.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

200

1.19

0.25

3.3

2.2

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

1.37

0.24

1.8

1.7

1.3

1.6

g/l

—

(40768443) Skin Pathology biopsy report

1.26

0.23

1.0

1.2

—

(3022145) Colonoscopy Study observation

103

0.76

0.22

1.0

1.3

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.20

0.22

5.8

6.3

24.7

24.8

mmol/l

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.1

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.21

0.0

1.5

—

28.2

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.2

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

4.6

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

2.6

—

86.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.1

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.21

0.0

1.3

—

203.1

—

(44790048)

0.00

0.21

0.0

1.8

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.3

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.21

0.0

1.2

—

6.4

—

(44790047)

0.00

0.21

0.0

1.8

—

(44806118)

0.00

0.21

0.0

1.8

—

(44790049)

0.00

0.21

0.0

1.8

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

2.8

—

89.2

—

(4268621)

0.00

0.21

0.0

2.2

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.5

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.4

—

3.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.24

0.20

1.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.20

0.0

1.3

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.20

0.0

1.8

—

2.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.20

0.0

1.5

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.20

0.0

1.2

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.20

0.0

1.5

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.20

0.0

1.3

—

(3008898) HLA-B27 [Presence]

1.21

0.20

1.0

1.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

237

0.86

0.20

4.2

3.7

8.1

11.1

mg/mmol

0.15

148

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

176

1.17

0.19

1.4

1.3

13.6

33.0

iu/ml

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

600

0.90

0.18

2.9

3.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.22

0.18

1.6

1.4

—

(3003694) ABO and Rh group [Type] in Blood

235

0.87

0.18

1.4

—

(3002256) Pathology report gross observation

111

1.19

0.16

1.5

1.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

836

1.13

0.16

17.1

12.9

84.3

83.0

ml/min/173m2

0.20

684

(3000492) Spirometry study

102

1.20

0.16

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

117

0.84

0.13

2.2

2.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

239

1.12

0.13

5.7

3.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

105

0.84

0.13

1.9

—

(3019225) pH of Specimen

1.19

0.13

5.7

4.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

219

0.89

0.12

3.4

4.1

17.0

22.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

136

0.87

0.11

2.0

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

166

0.89

0.10

2.2

1.5

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

155

0.89

0.10

2.5

2.7

0.4

0.8

ug/l

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.10

0.09

6.3

2.8

2.4

1.1

mmol/l

—

(3025941) Bacteria identified in Stool by Culture

1.04

0.08

1.3

1.2

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.08

0.08

3.7

1.8

465.7

119.0

ng/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.10

0.08

5.1

3.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

814

0.94

0.07

24.4

14.2

39.7

40.7

0.36

625

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

161

0.92

0.05

1.5

1.3

1.2

8.7

u/ml

—

(40761511) CBC panel - Blood by Automated count

930

1.07

0.04

19.6

12.4

—

(3012516) Albumin [Mass/volume] in Urine

219

0.95

0.03

2.9

3.0

34.2

372.5

mg/l

0.59

137

(3026493) Urate [Moles/volume] in Serum or Plasma

239

0.95

0.03

3.0

2.7

19868.8

2993.0

umol/l

0.40

209

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

286

0.97

0.00

4.3

1.2

2.0

ug/l

1.37

263

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

815

1.02

0.00

5.4

4.7

1.8

1.9

mu/l

0.17

753

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

205

0.97

0.00

1.5

1.2

3.1

1.1

u/ml

—

(3002385) Erythrocyte distribution width [Ratio]

736

1.02

0.00

26.3

17.0

13.8

13.7

0.30

725

(3018095) Leukocytes [#/volume] in Urine

314

0.98

0.00

5.0

3.3

277.3

41.4

e6/l

0.63

207

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.0

—

(4146454)

0.00

0.0

3.5

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

5.3

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.5

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(4281824)

0.00

0.0

1.0

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

12.7

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.00

0.00

6.7

2.7

5.0

4.9

kpa

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(4211845)

0.00

0.0

1.9

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

5.3

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.2

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

13.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

13.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.1

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.2

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

2.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.6

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.4

—

13.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(4010399)

0.97

0.00

1.0

1.4

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.4

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(36660697) Celiac disease serology panel - Serum

0.90

0.00

1.1

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.6

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.3

—

8.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_NEUROINFSEQ and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_NEUROINFSEQ	2.449 [1.58, 3.79]	< 0.001
Birth year	0.995 [0.99, 1.0]	0.263

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 211 females with G6_NEUROINFSEQ died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_NEUROINFSEQ.

N-year risk	Females	Males
1	0.273%	No data
5	1.534%	No data
10	3.802%	No data
15	6.743%	No data
20	11.591%	No data

Relationships between endpoints

↥

Index endpoint: G6_NEUROINFSEQ – Sequelae of inflammatory diseases of the central nervous system

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Sequelae of inflammatory diseases of the central nervous system

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints