eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Other/unspecified postprocedural disorders of ear and mastoid process
DOID EFO Endpoint Browser PheWeb
H8_POSTOPNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
98 |
4. Check minimum number of eventsNone |
98 |
5. Include endpointsNone |
98 |
6. Filter based on genotype QC (FinnGen only) |
98 |
Control definitions (FinnGen only)
- Control exclude
- H8_OTHEREAR
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other/unspecified postprocedural disorders of ear and mastoid process
based on the number of shared cases.
Similar with more cases:
- Postprocedural disorders of ear and mastoid process, not elsewhere classified
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 977 | 479 | 495 |
| Only index persons | 935 | 464 | 471 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 64.74 | 67.98 | 61.54 |
| Only index persons | 64.84 | 67.85 | 61.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 98 | 48 | 50 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 65.34 | 61.51 | 69.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 85
- Matched controls
- 848
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
87.0
68
*
UDC00
NOMESCO Finland
Ear microscopy
115.3
57.7
60
17
H71
ICD-10 Finland
Cholesteatoma of middle ear
680.1
42.0
38
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
113.7
29.0
30
*
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
24.1
22
*
H95.9
ICD-10 Finland
Postprocedural disorder of ear and mastoid process, unspecified
+∞
20.7
19
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
18.4
17
*
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
+∞
17.3
16
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
60.3
16.8
19
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
+∞
16.1
15
*
H66.9
ICD-10 Finland
Otitis media, unspecified
22.0
15.9
23
14
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
69.8
15.4
17
*
WX720
NOMESCO Finland
Own respiration
21.0
14.4
21
13
Z97.8
ICD-10 Finland
Presence of other specified devices
+∞
13.9
13
*
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
12.8
12
*
WX704
NOMESCO Finland
Intubation
10.2
12.7
26
35
DFF00
NOMESCO Finland
Pure tone audiometry
17.1
12.2
19
14
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
41.3
11.7
14
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
8.7
11.5
26
41
H65.3
ICD-10 Finland
Chronic mucoid otitis media
68.9
10.9
12
*
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
10.6
10
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
10.6
10
*
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
10.6
10
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
13.8
10.1
17
15
TDA90
NOMESCO Finland
Removal wax from ear
62.4
9.9
11
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
9.5
9
*
DCD00
NOMESCO Finland
Myringoplasty
56.0
8.9
10
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
31.1
8.7
11
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
99.5
8.6
9
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
10.7
8.5
16
18
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
8.5
8
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
8.5
8
*
WX702
NOMESCO Finland
Supraglottic ventilation device
13.7
8.4
14
12
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
6.5
8.3
22
43
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
17.2
8.0
12
8
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
49.7
7.9
9
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
28.0
7.8
10
*
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
+∞
7.4
7
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
7.4
7
*
WX725
NOMESCO Finland
Noninvasive ventilation
8.0
6.9
15
22
Z01.8
ICD-10 Finland
Other specified special examinations
3.8
6.6
31
111
DCD10
NOMESCO Finland
Tympanoplasty
75.3
6.5
7
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
7.3
6.5
15
24
DAX08
NOMESCO Finland
Fitting of hearing aid
29.1
6.3
8
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
760
0.27
9.57
12.9
14.7
79.3
76.7
ml/min/173m2
0.31
25
624
30
99
3.93
8.18
1.7
1.7
—
—
—
0
0
30
107
3.60
7.23
7.0
6.3
2.5
1.0
mmol/l
1.57
24
86
29
105
3.50
6.79
1.7
1.7
—
—
—
0
0
10
15
7.31
6.44
2.6
1.5
—
—
—
0
0
37
168
2.93
5.85
5.3
3.4
30.6
288.8
ng/l
1.85
31
139
31
142
2.73
4.70
1.9
1.8
—
—
—
0
0
7
5
14.91
4.65
1.3
1.2
—
—
—
0
0
10
28
3.86
3.29
3.1
2.0
—
—
—
0
0
0
79
0.00
3.12
0.0
3.6
—
1.2
—
0
71
55
393
1.91
2.51
6.1
5.3
1.2
1.2
mmol/l
1.23
50
352
8
181
0.39
2.10
4.4
2.4
—
—
—
0
0
56
444
1.61
1.48
6.0
6.2
9.2
11.2
umol/l
1.59
56
422
16
100
1.72
1.04
1.1
1.3
—
—
—
0
0
0
28
0.00
0.99
0.0
4.3
—
24.9
—
0
28
11
62
1.87
0.99
2.8
1.4
—
—
—
0
0
57
491
1.38
0.80
7.0
4.2
6.9
6.8
mmol/l
0.19
52
462
0
25
0.00
0.80
0.0
1.7
—
—
—
0
0
0
25
0.00
0.80
0.0
1.7
—
—
—
0
0
38
310
1.37
0.74
5.1
4.1
—
—
—
0
0
18
128
1.50
0.72
2.5
2.2
2.1
2.4
g/l
1.10
18
116
7
44
1.64
0.66
1.6
2.2
4.3
4.3
pmol/l
—
7
37
25
314
0.73
0.65
3.1
3.1
—
—
—
0
0
42
356
1.31
0.61
7.1
3.8
—
—
—
0
0
0
20
0.00
0.61
0.0
1.3
—
—
—
0
0
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
49
428
1.29
0.56
2.8
2.7
—
—
—
0
0
19
150
1.33
0.44
1.9
3.1
0.9
0.8
mmol/l
0.77
19
139
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
39
343
1.23
0.39
2.5
2.2
82.0
76.2
nmol/l
0.66
39
296
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
18
219
0.78
0.36
3.2
2.0
2.2
3.1
mg/l
1.12
18
192
25
291
0.81
0.34
4.4
3.1
2392.8
1255.7
ng/l
0.42
25
250
10
74
1.39
0.34
3.0
3.4
75.7
85.6
ng/l
—
10
64
13
101
1.33
0.34
4.7
4.1
263.5
239.7
u/l
0.22
13
96
39
352
1.18
0.29
2.2
2.1
100.3
93.9
pmol/l
0.47
20
183
67
637
1.16
0.24
7.9
7.4
84.3
79.4
u/l
0.40
67
595
7
92
0.74
0.23
35.0
9.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
13
109
1.22
0.20
4.8
4.2
1.0
1.0
mmol/l
0.13
13
98
75
772
0.88
0.16
5.2
4.7
4.6
4.5
mmol/l
0.25
75
694
7
88
0.78
0.15
1.7
3.6
5.6
5.8
kpa
—
7
82
85
832
1.16
0.13
26.2
18.2
82.0
79.6
umol/l
0.21
85
832
20
220
0.89
0.13
1.4
1.6
23.9
21.6
nmol/l
0.20
20
182
20
181
1.13
0.13
1.9
1.7
1061.4
1161.7
nmol/l
0.36
20
145
79
771
1.13
0.12
5.1
4.8
6.0
6.0
mmol/l
0.04
79
690
35
330
1.09
0.11
3.8
3.7
26.5
38.9
ng/l
0.71
27
242
32
339
0.92
0.11
3.4
2.6
142.6
130.1
ug/l
0.11
32
312
5
43
1.17
0.10
1.0
1.0
—
—
—
0
0
5
43
1.17
0.10
2.8
2.6
1.6
1.0
%
—
5
43
6
53
1.14
0.09
1.7
1.8
6.5
13.0
nmol/l
—
6
46
23
215
1.09
0.08
2.4
2.6
355.0
6169.7
umol/l
1.00
23
178
85
838
1.11
0.07
12.2
10.7
24.6
24.0
u/l
0.20
85
804
12
130
0.91
0.05
1.4
1.2
21.9
42.8
iu/ml
—
7
49
79
799
0.94
0.03
24.0
15.1
25.2
24.8
mg/l
0.04
69
630
28
273
1.04
0.01
5.6
4.9
24.4
20.8
%
0.49
14
135
18
183
0.98
0.00
1.9
1.8
2.1
1.5
mg/l
0.17
12
143
83
835
0.96
0.00
28.4
17.4
3.9
4.0
mmol/l
1.25
83
807
83
834
0.97
0.00
28.3
17.3
139.7
139.7
mmol/l
0.09
83
806
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
0.00
0.0
4.2
—
107.6
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_POSTOPNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTOPNAS | 1.092 [0.84, 1.41] | 0.506 |
| Birth year | 0.991 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 440 females with H8_POSTOPNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTOPNAS | 1.324 [0.98, 1.79] | 0.067 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 441 males with H8_POSTOPNAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_POSTOPNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.227% |
| 5 | 0.539% | 1.316% |
| 10 | 1.37% | 3.49% |
| 15 | 2.665% | 6.444% |
| 20 | 4.665% | 10.797% |
Relationships between endpoints
↥Index endpoint: H8_POSTOPNAS – Other/unspecified postprocedural disorders of ear and mastoid process
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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