eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Other/unspecified postprocedural disorders of ear and mastoid process
DOID EFO Endpoint Browser PheWeb
H8_POSTOPNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
102 |
4. Check minimum number of eventsNone |
102 |
5. Include endpointsNone |
102 |
6. Filter based on genotype QC (FinnGen only) |
93 |
Control definitions (FinnGen only)
- Control exclude
- H8_OTHEREAR
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other/unspecified postprocedural disorders of ear and mastoid process
based on the number of shared cases.
Similar with more cases:
- Postprocedural disorders of ear and mastoid process, not elsewhere classified
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 977 | 479 | 495 |
| Only index persons | 935 | 464 | 471 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 64.74 | 67.98 | 61.54 |
| Only index persons | 64.84 | 67.85 | 61.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 93 | 42 | 51 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 66.23 | 62.83 | 69.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 102
- Matched controls
- 1020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UDC00
NOMESCO Finland
Ear microscopy
100.2
120.3
73
25
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
105.2
82
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
158.0
45.3
45
5
DFF00
NOMESCO Finland
Pure tone audiometry
21.7
39.2
33
22
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
88.7
36.4
39
7
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
32.0
29
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
27.3
25
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
11.6
25.5
31
37
H95.9
ICD-10 Finland
Postprocedural disorder of ear and mastoid process, unspecified
+∞
25.0
23
*
WX704
NOMESCO Finland
Intubation
11.9
24.6
29
33
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
103.2
22.8
24
*
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
+∞
19.4
18
*
WX720
NOMESCO Finland
Own respiration
18.8
18.2
28
20
H66.9
ICD-10 Finland
Otitis media, unspecified
17.1
17.5
28
22
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
57.7
16.7
19
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
101.0
16.1
17
*
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
187.6
16.0
16
*
TDA90
NOMESCO Finland
Removal wax from ear
160.5
13.8
14
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
160.5
13.8
14
*
Z01.8
ICD-10 Finland
Other specified special examinations
4.8
12.9
40
120
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
12.8
12
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
6.3
12.7
25
50
Z97.8
ICD-10 Finland
Presence of other specified devices
73.6
11.9
13
*
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
73.6
11.9
13
*
DCD00
NOMESCO Finland
Myringoplasty
134.6
11.7
12
*
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
134.6
11.7
12
*
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
134.6
11.7
12
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
10.3
11.6
23
28
DAX08
NOMESCO Finland
Fitting of hearing aid
32.0
11.1
14
5
DFF15
NOMESCO Finland
Speech audiometry
32.0
11.1
14
5
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
67.2
10.9
12
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
122.0
10.6
11
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
10.6
10
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
10.6
10
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
9.5
10.3
21
27
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
44.8
10.2
12
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
24.5
9.6
13
6
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
+∞
9.5
9
*
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
17.8
9.3
14
9
N03AX12
ATC
[U] gabapentin; oral
4.1
9.1
32
103
SPAT1301
SPAT
No procedures
3.5
8.9
48
206
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
97.8
8.6
9
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
97.8
8.6
9
*
WX725
NOMESCO Finland
Noninvasive ventilation
7.8
8.4
19
29
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
7.0
8.2
20
34
WX702
NOMESCO Finland
Supraglottic ventilation device
7.5
8.2
19
30
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
4.4
8.2
24
67
TPH04
NOMESCO Finland
Cathetrisation of vein
3.4
7.8
38
151
H65.2
ICD-10 Finland
Chronic serous otitis media
27.4
7.7
10
*
SPAT1097
SPAT
Recording of ECG
3.8
7.6
28
92
DCD10
NOMESCO Finland
Tympanoplasty
86.1
7.5
8
*
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
86.1
7.5
8
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
86.1
7.5
8
*
S02CA02
ATC
flumetasone and antiinfectives; otic
7.0
7.5
18
30
H73.1
ICD-10 Finland
Chronic myringitis
+∞
7.4
7
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.6
7.0
18
45
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
43.0
6.9
8
*
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
43.0
6.9
8
*
I20.01
ICD-10 Finland
Unstable angina
12.1
6.5
11
10
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.9
6.4
21
63
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
+∞
6.3
6
*
J01DA09
ATC
[U] cefadroxil
3.0
6.3
37
162
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
789
0.28
9.15
13.3
15.3
75.20
76.51
ml/min/173m2
0.11
28
647
31
104
3.85
8.23
1.7
1.8
—
—
—
0
0
30
110
3.45
6.87
1.7
1.8
—
—
—
0
0
30
115
3.28
6.36
7.0
6.3
2.53
0.99
mmol/l
1.66
24
92
39
178
2.93
6.10
5.1
3.6
29.55
272.95
ng/l
1.86
33
148
11
16
7.56
5.10
2.5
1.5
—
—
—
0
0
7
5
14.88
4.64
1.3
1.2
—
—
—
0
0
32
150
2.65
4.60
1.8
1.9
—
—
—
0
0
11
273
0.33
3.20
2.9
3.2
0.10
0.43
e6/l
1.76
11
212
0
80
0.00
3.10
0.0
3.7
—
1.23
—
0
73
10
28
3.84
2.87
3.1
2.0
—
—
—
0
0
58
409
1.97
2.82
6.6
5.4
1.20
1.21
mmol/l
0.72
53
372
6
10
6.29
2.74
6.2
6.4
10.17
10.28
mg/l
—
6
10
59
436
1.84
2.32
18.8
15.3
1.67
1.36
inr
0.55
15
120
59
463
1.65
1.67
5.9
6.3
9.13
11.99
umol/l
2.36
59
444
10
193
0.47
1.50
3.7
2.4
—
—
—
0
0
38
278
1.58
1.37
2.4
3.9
7.85
11.78
mg/mmol
0.36
20
181
0
29
0.00
0.99
0.0
4.2
—
24.95
—
0
29
16
102
1.67
0.97
1.1
1.3
—
—
—
0
0
11
63
1.84
0.94
2.8
1.5
—
—
—
0
0
40
320
1.41
0.88
5.2
4.1
—
—
—
0
0
59
510
1.37
0.80
7.1
4.4
6.91
6.78
mmol/l
0.18
54
482
0
26
0.00
0.79
0.0
1.7
—
—
—
0
0
0
26
0.00
0.79
0.0
1.7
—
—
—
0
0
12
77
1.63
0.72
3.3
3.6
76.16
86.80
ng/l
0.30
12
68
5
29
1.76
0.64
1.0
1.9
—
—
—
0
0
19
140
1.44
0.64
2.7
2.3
2.11
2.32
g/l
1.04
19
127
42
354
1.32
0.63
2.4
2.2
80.45
75.58
nmol/l
0.55
42
307
51
442
1.31
0.63
2.8
2.7
—
—
—
0
0
44
375
1.30
0.61
3.6
2.5
—
—
—
0
0
0
22
0.00
0.60
0.0
1.3
—
—
—
0
0
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
27
331
0.75
0.58
3.3
3.2
—
—
—
0
0
7
46
1.56
0.49
1.6
2.2
4.31
4.32
pmol/l
—
7
39
42
365
1.26
0.48
2.1
2.1
100.04
93.47
pmol/l
0.54
22
192
26
309
0.79
0.43
4.2
3.1
2698.73
1245.98
ng/l
0.59
26
267
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
20
164
1.27
0.36
2.0
3.1
0.85
0.82
mmol/l
0.72
20
152
19
229
0.79
0.35
3.4
2.1
2.19
3.06
mg/l
1.11
19
202
6
44
1.39
0.35
5.2
2.5
1.52
0.95
%
—
6
44
70
658
1.20
0.33
7.9
7.7
83.24
81.20
u/l
0.14
70
619
14
111
1.30
0.32
4.4
3.8
255.36
236.82
u/l
0.18
14
106
26
226
1.20
0.28
2.4
2.6
356.35
5920.76
umol/l
1.00
26
186
22
188
1.22
0.28
1.8
1.7
1079.23
1157.13
nmol/l
0.26
22
154
89
860
1.27
0.28
26.0
18.8
86.64
80.35
umol/l
0.49
89
860
83
801
1.19
0.23
5.2
4.8
6.03
6.06
mmol/l
0.07
83
720
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
37
341
1.13
0.19
3.6
3.9
27.78
41.69
ng/l
0.84
29
252
89
867
1.21
0.19
12.1
10.9
24.61
24.59
u/l
0.00
89
834
14
121
1.18
0.16
5.6
4.2
1.04
1.04
mmol/l
0.03
14
108
33
354
0.90
0.15
3.6
2.6
150.30
140.38
ug/l
0.08
33
326
8
96
0.82
0.14
3.6
3.6
5.66
5.79
kpa
—
8
89
91
893
1.18
0.13
32.1
23.1
40.63
39.52
%
1.06
55
838
91
894
1.17
0.12
32.4
23.1
132.47
133.67
g/l
0.31
91
877
11
125
0.87
0.11
6.4
6.7
104.91
104.12
mmol/l
0.36
11
125
5
45
1.12
0.10
1.0
1.0
—
—
—
0
0
6
58
1.04
0.08
1.7
1.9
6.53
12.68
nmol/l
—
6
52
8
91
0.87
0.07
34.4
9.0
—
—
—
0
0
22
232
0.93
0.05
1.4
1.7
22.58
21.34
nmol/l
0.11
22
196
79
798
0.96
0.02
5.2
4.7
4.56
4.48
mmol/l
0.25
79
723
87
863
1.06
0.01
27.9
17.8
139.76
139.63
mmol/l
0.15
87
835
87
864
1.05
0.00
28.1
18.0
3.94
3.99
mmol/l
1.13
87
836
20
194
1.04
0.00
1.8
1.7
1.94
1.61
mg/l
0.10
14
154
29
288
1.01
0.00
5.6
4.9
24.16
21.05
%
0.44
15
141
13
134
0.97
0.00
1.4
1.2
23.38
41.56
iu/ml
—
8
49
83
826
1.03
0.00
23.4
15.6
24.71
25.18
mg/l
0.04
72
655
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
-0.00
0.0
4.2
—
107.60
—
0
5
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_POSTOPNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTOPNAS | 1.092 [0.84, 1.41] | 0.506 |
| Birth year | 0.991 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 440 females with H8_POSTOPNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTOPNAS | 1.324 [0.98, 1.79] | 0.067 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 441 males with H8_POSTOPNAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_POSTOPNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.227% |
| 5 | 0.539% | 1.316% |
| 10 | 1.37% | 3.49% |
| 15 | 2.665% | 6.444% |
| 20 | 4.665% | 10.797% |
Relationships between endpoints
↥Index endpoint: H8_POSTOPNAS – Other/unspecified postprocedural disorders of ear and mastoid process
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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