Postprocedural disorders of ear and mastoid process, not elsewhere classified

H8_POSTOP

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

294

6. Filter based on genotype QC (FinnGen only)

275

Control definitions (FinnGen only)

Control exclude
H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Similar endpoints

List of similar endpoints to Postprocedural disorders of ear and mastoid process, not elsewhere classified based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2836 1357 1468
Only index persons 2677 1286 1391
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 61.03 64.13 58.11
Only index persons 60.48 63.48 57.72

-FinnGen-

Key figures

All Female Male
Number of individuals 275 129 146
Unadjusted period prevalence (%) 0.06 0.05 0.07
Median age at first event (years) 61.55 60.59 62.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
294
Matched controls
2940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UDC00
NOMESCO Finland
Ear microscopy
83.2
302.4
179
54
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
83.5
195.7
107
20
H71
ICD-10 Finland
Cholesteatoma of middle ear
512.4
180.8
163
7
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
161.9
140
*
DFF00
NOMESCO Finland
Pure tone audiometry
28.3
131.8
98
51
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
+∞
125.2
111
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
13.2
88.8
102
114
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
1127.3
88.5
82
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
47.6
80.3
48
12
Z97.4
ICD-10 Finland
Presence of external hearing-aid
39.8
75.0
47
14
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
74.2
68
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
24.8
74.1
55
27
DAX08
NOMESCO Finland
Fitting of hearing aid
33.9
70.0
46
16
H66.9
ICD-10 Finland
Otitis media, unspecified
13.8
61.8
63
57
DFF15
NOMESCO Finland
Speech audiometry
26.3
60.0
43
19
H65.3
ICD-10 Finland
Chronic mucoid otitis media
29.6
59.8
41
16
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
176.3
44.1
45
*
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
176.3
44.1
45
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
8.8
41.4
58
80
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
237.2
41.0
41
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
83.4
39.1
43
6
H60.9
ICD-10 Finland
Otitis externa, unspecified
8.8
38.2
53
72
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
81.2
38.1
42
6
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
63.9
34.2
39
7
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
348.0
31.5
31
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
30.8
29
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
335.0
30.4
30
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
335.0
30.4
30
*
S02CA02
ATC
flumetasone and antiinfectives; otic
7.1
30.0
50
83
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
29.7
28
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
29.7
28
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
115.1
29.3
31
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.4
29.1
67
152
WX720
NOMESCO Finland
Own respiration
8.2
28.7
41
57
DEB30
NOMESCO Finland
Radical mastoidectomy
160.2
28.2
29
*
DCD00
NOMESCO Finland
Myringoplasty
106.9
27.2
29
*
WX704
NOMESCO Finland
Intubation
5.9
26.8
54
108
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
79.9
26.3
29
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
25.4
24
*
H95.9
ICD-10 Finland
Postprocedural disorder of ear and mastoid process, unspecified
+∞
24.3
23
*
TDA90
NOMESCO Finland
Removal wax from ear
51.4
23.8
28
6
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
90.8
23.0
25
*
DC1AD
NOMESCO Finland
Temporalbone CT
56.7
22.5
26
5
DCD10
NOMESCO Finland
Tympanoplasty
236.9
21.9
22
*
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
17.5
21.1
33
21
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
118.5
20.9
22
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
19.1
20.5
31
18
WX725
NOMESCO Finland
Noninvasive ventilation
5.8
20.0
39
75
Z97.8
ICD-10 Finland
Presence of other specified devices
112.7
19.8
21
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
75.0
19.0
21
*
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
+∞
19.0
18
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
101.3
17.8
19
*
Z01.8
ICD-10 Finland
Other specified special examinations
3.1
17.4
95
388
4151
FHL
Reoperation for chronic otitis media
+∞
16.8
16
*
H65.2
ICD-10 Finland
Chronic serous otitis media
30.5
15.4
20
7
WX702
NOMESCO Finland
Supraglottic ventilation device
5.1
15.1
34
74
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.8
14.7
108
512
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
18.2
14.5
22
13
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
44.9
14.3
17
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.3
14.2
39
100
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
35.9
13.7
17
5
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
22.5
13.5
19
9
H60.3
ICD-10 Finland
Other infective otitis externa
12.4
13.1
23
20
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
11.3
13.0
24
23
Z98.8
ICD-10 Finland
Other specified postsurgical states
16.4
12.8
20
13
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
135.6
12.5
13
*
H60.4
ICD-10 Finland
Cholesteatoma of external ear
135.6
12.5
13
*
H92.0
ICD-10 Finland
Otalgia
5.5
12.4
25
49
H93.1
ICD-10 Finland
Tinnitus
12.5
12.0
21
18
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.4
12.0
168
1054
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
11.5
11
*
J01DA09
ATC
[U] cefadroxil
2.4
10.9
96
486
H73.1
ICD-10 Finland
Chronic myringitis
+∞
10.5
10
*
ZZG00
NOMESCO Finland
Graft of cartilage
+∞
10.5
10
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.6
10.0
69
310
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
9.8
64
280
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
56.9
9.7
11
*
H91.1
ICD-10 Finland
Presbycusis
5.4
9.5
19
37
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
103.2
9.5
10
*
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
19.3
9.0
13
7
H69.0
ICD-10 Finland
Patulous Eustachian tube
24.9
9.0
12
5
R5120
NOMESCO Finland
Preparation of an aid
9.4
8.7
17
19
H61.2
ICD-10 Finland
Impacted cerumen
3.6
8.5
29
87
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
+∞
8.4
8
*
H66.2
ICD-10 Finland
Chronic atticoantral suppurative otitis media
+∞
8.4
8
*
DED00
NOMESCO Finland
Obliteration of cavity after partial excision of mastoid
+∞
8.4
8
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.8
8.0
45
181
J01MA02
ATC
ciprofloxacin; systemic
2.0
7.9
133
854
DGW00
NOMESCO Finland
Dilatation of eustachian tube
46.2
7.8
9
*
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
46.2
7.8
9
*
ICB01, ,
SPAT
46.2
7.8
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
7.7
80
428
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.0
7.4
120
756
WZC00, ,
SPAT
2.9
7.3
37
141
H61.8
ICD-10 Finland
Other specified disorders of external ear
16.2
7.3
11
7
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
4.7
7.3
17
38
N03AX12
ATC
[U] gabapentin; oral
2.3
7.2
60
291
H60.8
ICD-10 Finland
Other otitis externa
5.9
7.2
19
34
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
30.8
7.2
9
*
SPAT1301
SPAT
No procedures
2.0
7.0
110
682
SPAT1097
SPAT
Recording of ECG
2.3
6.8
57
277
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
6.7
46
205
4141
FHL
Myringoplasty (also for reasons other than inflammation)
71.3
6.5
7
*
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
5.4
6.4
18
35
-31
ICPC
Medical examin/health eval partial
3.0
6.4
29
104
Z3229
NOMESCO Finland
Other healthcare associate professional
2.9
6.3
30
110
DEB00
NOMESCO Finland
Cortical mastoidectomy
+∞
6.3
6
*
H61.3
ICD-10 Finland
Acquired stenosis of external ear canal
27.3
6.3
8
*
H90.5
ICD-10 Finland
Sensorineural hearing loss, unspecified
27.3
6.3
8
*
J01DA06
ATC
[U] cefuroxime
2.3
6.1
51
247
S02AA03
ATC
boric acid; otic
12.9
6.1
10
8
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
5.8
6.1
16
29
H65.0
ICD-10 Finland
Acute serous otitis media
10.3
6.1
11
11

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
90
261
4.53
29.01
2.4
1.7
—
—
—
0
0
47
143
3.72
13.54
6.7
7.5
—
—
—
0
0
53
198
3.05
10.94
4.2
4.7
—
—
—
0
0
65
274
2.76
10.76
1.7
1.4
—
—
—
0
0
86
498
2.03
6.59
5.4
4.0
22.79
280.60
ng/l
2.62
77
409
62
318
2.20
6.52
5.8
6.9
2.48
1.28
mmol/l
1.65
47
251
57
1002
0.47
6.36
9.1
9.4
0.00
0.00
e9/l
1.48
48
831
61
319
2.15
6.09
5.7
6.8
4.99
5.13
kpa
0.44
56
305
107
722
1.76
4.89
4.1
3.2
7.13
7.33
mmol/l
0.19
94
606
60
342
1.95
4.68
2.4
1.9
—
—
—
0
0
10
16
6.43
4.33
2.0
2.3
—
—
—
0
0
104
739
1.63
3.74
3.4
3.9
10.25
11.91
mg/mmol
0.14
56
469
98
701
1.60
3.38
3.1
3.3
47.57
218.63
mg/l
0.94
52
472
9
22
4.19
2.90
1.2
1.8
—
—
—
0
0
217
1892
1.56
2.83
27.1
20.9
332.30
331.67
g/l
0.52
217
1879
85
611
1.55
2.80
1.8
1.7
1.40
1.32
mmol/l
0.42
77
512
48
724
0.60
2.73
4.2
3.2
0.51
0.43
e6/l
0.09
39
554
192
1638
1.50
2.72
5.9
4.4
—
—
—
0
0
151
1229
1.47
2.71
7.2
6.7
1.22
1.21
mmol/l
0.35
137
1040
54
790
0.61
2.71
4.0
3.3
35.37
72.26
e6/l
0.75
46
615
23
113
2.12
2.70
2.7
2.4
—
—
—
0
0
8
209
0.37
2.67
2.5
3.2
1.21
1.22
mmol/l
—
8
184
237
2126
1.59
2.55
4.6
4.6
2.08
1.95
mu/l
0.90
217
1900
73
522
1.53
2.44
4.8
4.2
1.02
1.02
kg/l
0.19
21
82
198
1720
1.46
2.40
3.6
3.8
14.77
14.91
pmol/l
0.37
185
1533
168
1416
1.44
2.39
5.2
4.7
6.86
6.75
mmol/l
0.29
154
1332
8
204
0.38
2.39
7.0
3.8
—
—
—
0
0
139
1140
1.42
2.27
5.4
5.7
1.21
1.21
mmol/l
0.11
128
1040
33
524
0.58
2.26
3.1
3.0
0.69
0.76
ug/l
0.42
21
354
244
2224
1.57
2.23
5.0
4.8
5.97
6.03
mmol/l
0.33
233
1998
40
602
0.61
2.21
3.8
3.9
89.05
87.11
%
0.20
40
591
49
702
0.64
2.18
3.9
3.1
—
—
—
0
0
147
1225
1.40
2.15
19.5
15.8
1.48
1.33
inr
0.45
30
344
93
718
1.43
2.09
4.3
4.4
—
—
—
0
0
49
696
0.64
2.09
2.8
3.1
—
—
—
0
0
10
37
2.76
2.09
1.0
1.3
0.31
0.67
g/l
—
5
32
31
489
0.59
2.06
2.4
2.8
2.47
2.45
mmol/l
0.32
23
433
35
534
0.61
2.04
3.5
3.0
504.54
553.76
mosm/kgh2o
0.72
28
453
256
2375
1.60
1.98
21.4
14.5
—
—
—
0
0
166
1428
1.37
1.93
3.5
2.9
59.13
50.93
u/l
0.42
151
1330
56
760
0.67
1.89
2.5
2.5
—
—
—
0
0
7
22
3.23
1.89
1.1
1.2
—
—
—
0
0
69
900
0.70
1.88
3.8
3.8
22.49
171.97
e6/l
1.28
48
651
71
531
1.44
1.88
1.5
1.8
225000369.84
12984473.46
pmol/l
0.73
64
439
122
1006
1.36
1.82
2.1
2.1
90.42
93.10
pmol/l
0.31
68
515
235
2157
1.45
1.76
6.2
6.0
40.23
40.45
mmol/mol
0.14
220
1985
34
222
1.60
1.69
1.6
1.6
—
—
—
0
0
127
1068
1.33
1.63
5.7
4.4
34.15
35.14
g/l
1.09
114
1008
27
414
0.62
1.61
3.2
3.1
2.05
2.30
e6/l
0.10
20
228
7
27
2.63
1.52
1.4
1.3
—
—
—
0
0
12
226
0.51
1.49
1.7
1.4
—
—
—
0
0
6
22
2.76
1.44
1.0
1.2
—
—
—
0
0
179
1603
1.30
1.37
5.8
4.7
—
4405.79
—
0
33
14
243
0.55
1.35
1.0
1.3
—
—
—
0
0
30
426
0.67
1.27
1.3
1.4
2.55
2.43
g/l
0.10
19
249
63
494
1.35
1.26
1.6
1.8
1013.35
1230.67
nmol/l
1.50
52
375
187
1695
1.28
1.25
5.0
4.1
14.88
13.51
mm/h
0.57
176
1534
9
45
2.03
1.24
1.3
1.2
—
—
—
0
0
93
776
1.29
1.20
3.4
3.6
7.44
7.40
ph
—
6
144
257
2440
1.42
1.20
11.5
10.6
24.59
24.95
u/l
0.17
247
2348
6
26
2.33
1.19
2.8
2.9
33.83
3.47
nmol/l
—
6
26
96
806
1.28
1.18
4.4
3.3
—
—
—
0
0
46
597
0.73
1.17
5.4
6.6
—
—
—
0
0
0
35
0.00
1.16
0.0
1.1
—
—
—
0
0
51
644
0.75
1.09
6.2
4.1
0.00
0.00
estimate
—
6
209
13
215
0.59
1.07
9.8
7.8
—
—
—
0
0
264
2528
1.43
1.07
27.7
23.0
40.25
40.03
%
0.23
196
2358
44
565
0.74
1.05
2.9
2.5
3.54
4.89
e6/l
0.89
38
508
59
723
0.77
1.01
4.3
4.1
—
—
—
0
0
0
31
0.00
0.97
0.0
2.5
—
—
—
0
0
109
951
1.23
0.94
3.3
4.0
120.36
41.07
ng/l
0.39
74
724
23
159
1.48
0.94
1.3
1.2
—
—
—
0
0
101
1153
0.81
0.93
5.9
5.1
0.00
0.00
estimate
—
6
217
234
2225
1.25
0.81
4.7
4.5
4.52
4.53
mmol/l
0.07
217
2026
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
70
593
1.24
0.79
2.4
2.8
375.24
6197.28
umol/l
2.18
63
505
240
2291
1.26
0.79
5.4
5.1
2.62
2.65
mmol/l
0.21
221
2069
15
219
0.67
0.76
8.5
6.5
1.34
1.40
mmol/l
0.12
15
213
8
134
0.59
0.75
1.4
1.2
—
35.35
—
0
10
53
634
0.80
0.74
4.0
3.5
—
—
—
0
0
193
1811
1.19
0.71
8.1
7.5
82.70
78.34
u/l
0.45
184
1696
23
306
0.73
0.71
1.3
1.3
—
—
—
0
0
7
41
1.72
0.70
1.6
2.6
66.56
64.43
%
—
7
41
12
180
0.65
0.70
1.2
2.3
—
—
—
0
0
7
43
1.64
0.67
1.6
3.1
—
—
—
0
0
74
846
0.83
0.67
2.5
3.3
2.35
2.35
mmol/l
0.01
64
751
239
2296
1.22
0.63
19.9
15.6
24.40
25.33
mg/l
0.16
203
1850
13
88
1.50
0.61
1.1
1.2
—
—
—
0
0
27
342
0.77
0.61
1.4
1.3
1.62
11.17
u/ml
—
5
126
174
1632
1.16
0.60
4.8
4.2
—
—
—
0
0
58
497
1.21
0.60
1.7
1.8
1.73
1.42
mg/l
0.29
44
388
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
107
1172
0.86
0.56
4.6
3.8
0.00
0.00
estimate
—
7
213
29
233
1.27
0.53
3.3
2.9
77.56
69.57
e9/l
0.58
23
182
81
902
0.86
0.53
2.5
2.1
—
—
—
0
0
9
133
0.67
0.53
4.3
6.6
24.12
24.97
mmol/l
—
9
133
9
63
1.44
0.53
1.6
2.0
—
—
—
0
0
11
75
1.48
0.51
5.6
12.2
—
—
—
0
0
40
470
0.83
0.49
1.4
1.2
4.20
1.63
u/ml
—
9
116
15
197
0.75
0.45
3.3
2.9
4.51
4.47
kpa
0.03
15
186
30
359
0.82
0.44
1.4
1.3
19.00
36.36
iu/ml
1.06
14
116
118
1096
1.13
0.43
3.0
2.6
—
—
—
0
0
22
176
1.27
0.43
1.6
1.5
—
—
—
0
0
8
58
1.39
0.42
1.0
1.1
—
—
—
0
0
5
33
1.52
0.41
1.6
2.4
8.78
115.56
u/ml
—
5
33
5
33
1.52
0.41
1.2
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
193.69
—
0
15
228
2208
1.15
0.41
4.6
4.5
1.40
1.46
mmol/l
1.35
211
1994
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.9
—
36.98
—
0
18
123
1151
1.12
0.39
5.6
5.7
0.19
0.19
e9/l
0.16
114
1009
9
66
1.37
0.38
1.8
1.7
—
—
—
0
0
5
37
1.36
0.37
1.2
1.2
—
—
—
0
0
112
1048
1.11
0.36
5.9
6.2
—
—
—
0
0
53
586
0.88
0.32
1.2
1.4
—
—
—
0
0
7
53
1.33
0.31
2.9
3.0
0.69
1.04
nmol/l
—
7
40
121
1146
1.09
0.30
5.6
5.6
1.78
1.89
e9/l
0.43
114
1017
9
119
0.75
0.28
5.3
4.4
—
—
—
0
0
29
331
0.86
0.28
6.7
6.8
104.83
104.23
mmol/l
0.27
29
331
38
342
1.13
0.24
2.2
2.4
21.69
22.11
%
0.05
16
299
128
1335
0.93
0.24
8.9
9.1
4.60
4.22
e9/l
0.75
120
1175
5
40
1.25
0.22
1.4
1.1
0.95
0.80
nmol/l
—
5
32
17
199
0.85
0.22
1.6
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
11.9
—
1407.00
—
0
11
0
11
0.00
0.21
0.0
1.3
—
117.84
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
2246.82
—
0
11
0
11
0.00
0.21
0.0
9.3
—
845.73
—
0
11
0
10
0.00
0.21
0.0
9.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
81.10
—
0
10
0
12
0.00
0.21
0.0
1.1
—
39.20
—
0
7
0
13
0.00
0.21
0.0
4.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
4.92
—
0
13
117
1122
1.07
0.20
5.7
5.5
0.04
0.04
e9/l
0.65
110
972
0
14
0.00
0.20
0.0
1.5
—
1669.43
—
0
14
7
59
1.19
0.18
2.0
2.7
30.57
35.33
umol/l
—
7
51
30
273
1.11
0.17
1.5
1.5
—
—
—
0
0
116
1119
1.06
0.16
5.8
5.5
0.61
0.60
e9/l
0.22
110
963
12
141
0.84
0.16
1.1
1.2
27.47
154.57
iu/ml
—
7
49
216
2122
1.07
0.16
3.9
4.0
1.31
1.25
mmol/l
0.66
200
1899
17
149
1.15
0.16
1.1
1.3
—
—
—
0
0
6
77
0.77
0.16
3.0
3.4
—
—
—
0
0
14
121
1.16
0.15
3.3
2.7
1.41
1.13
%
0.72
14
121
61
643
0.94
0.15
2.4
2.0
2.32
3.25
mg/l
3.37
54
548
79
756
1.06
0.14
2.2
2.2
681.96
229.77
u/l
0.63
74
707
13
112
1.17
0.14
1.8
4.5
—
—
—
0
0
11
128
0.85
0.14
1.5
1.3
—
—
—
0
0
23
210
1.10
0.12
3.3
3.5
94.78
85.88
ng/l
0.24
23
187
26
241
1.09
0.11
1.8
2.0
93.38
149.26
ug/g
0.82
21
185
20
218
0.91
0.10
1.3
2.5
62.19
66.36
g/l
1.46
20
196
14
156
0.89
0.10
1.4
1.6
—
—
—
0
0
22
238
0.92
0.10
3.0
3.9
5.53
5.80
kpa
0.68
22
229
5
44
1.14
0.10
5.2
3.3
9.22
8.09
kpa
—
5
44
10
114
0.87
0.09
1.3
3.0
15.08
42.24
u/ml
—
10
109
13
145
0.89
0.09
1.5
1.4
—
—
—
0
0
6
55
1.09
0.09
1.2
1.3
—
—
—
0
0
6
58
1.04
0.08
1.5
1.2
—
—
—
0
0
5
60
0.83
0.08
26.0
1.4
—
—
—
0
0
6
72
0.83
0.07
1.2
2.6
20.93
25.35
mmol/l
—
6
72
11
122
0.90
0.07
4.0
3.1
—
—
—
0
0
14
152
0.92
0.06
1.4
1.4
—
—
—
0
0
32
334
0.95
0.05
1.4
1.7
—
—
—
0
0
63
614
1.03
0.05
1.5
1.6
17.42
20.91
nmol/l
1.08
57
512
16
170
0.94
0.04
4.4
2.5
—
—
—
0
0
12
111
1.08
0.04
1.3
1.4
—
—
—
0
0
53
539
0.98
0.02
4.9
3.8
—
—
—
0
0
28
288
0.97
0.02
1.5
1.3
—
—
—
0
0
11
117
0.94
0.02
3.8
2.1
1.46
1.55
g/l
—
5
102
89
898
0.99
0.01
4.8
5.2
7.23
2.42
ug/l
0.48
77
779
14
134
1.05
0.00
1.0
1.6
0.63
1.39
g/l
2.54
14
124
20
194
1.03
0.00
5.3
3.8
—
—
—
0
0
116
1154
1.01
0.00
4.4
3.8
0.00
0.00
estimate
—
7
234
12
118
1.02
0.00
3.3
2.7
0.61
0.65
%
0.29
12
118
24
235
1.02
0.00
3.5
4.9
—
—
—
0
0
14
136
1.03
0.00
1.1
1.3
—
—
—
0
0
22
224
0.98
0.00
1.3
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
4.1
—
54.78
—
0
9
9
90
1.00
-0.00
2.8
1.9
—
—
—
0
0
9
97
0.93
-0.00
5.6
4.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
59
0.84
-0.00
25.4
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
53
0.94
-0.00
2.6
2.0
142.20
127.87
g/l
—
5
39
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
49
1.02
-0.00
1.2
1.4
69.80
64.27
mmol/l
—
5
44
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
56
0.89
-0.00
1.4
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
59
0.84
-0.00
25.4
1.4
—
—
—
0
0
5
55
0.91
-0.00
25.4
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
1.77
—
0
6
0
6
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
29.88
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
17
170
1.00
-0.00
1.9
2.7
8.56
10.83
g/l
2.51
17
151
0
8
0.00
-0.00
0.0
1.6
—
14.64
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
60
1.00
-0.00
4.8
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
59
0.84
-0.00
4.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H8_POSTOP and mortality.

Females

Parameter HR [95% CI] p-value
H8_POSTOP 1.144 [0.98, 1.33] 0.082
Birth year 0.996 [0.99, 1.0] 0.295

During the follow-up period (1.1.1998 — 31.12.2019), 277 out of 1246 females with H8_POSTOP died.

Males

Parameter HR [95% CI] p-value
H8_POSTOP 1.039 [0.89, 1.21] 0.623
Birth year 0.989 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 310 out of 1325 males with H8_POSTOP died.

Mortality risk

Mortality risk for people of age

years, who have H8_POSTOP.

N-year risk Females Males
1 0.115% 0.218%
5 0.677% 1.277%
10 1.588% 3.284%
15 3.028% 6.119%
20 5.623% 10.166%

Relationships between endpoints

Index endpoint: H8_POSTOP – Postprocedural disorders of ear and mastoid process, not elsewhere classified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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