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Postprocedural disorders of ear and mastoid process, not elsewhere classified

DOID EFO Endpoint Browser PheWeb

H8_POSTOP

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

288

6. Filter based on genotype QC (FinnGen only)

288

Control definitions (FinnGen only)

Control exclude
H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Similar endpoints

↥

List of similar endpoints to Postprocedural disorders of ear and mastoid process, not elsewhere classified based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2836 1357 1468
Only index persons 2677 1286 1391
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 61.03 64.13 58.11
Only index persons 60.48 63.48 57.72

-FinnGen-

Key figures

All Female Male
Number of individuals 288 143 145
Unadjusted period prevalence (%) 0.06 0.05 0.06
Median age at first event (years) 61.46 60.77 62.15

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
260
Matched controls
2598
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H71
ICD-10 Finland
Cholesteatoma of middle ear
1097.8
164.4
144
*
UDC00
NOMESCO Finland
Ear microscopy
78.4
141.7
158
50
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
136.9
119
*
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
+∞
119.1
105
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
90.8
83.4
90
15
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
74.6
68
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
60.8
56
*
DFF00
NOMESCO Finland
Pure tone audiometry
31.9
51.9
69
29
Z01.1
ICD-10 Finland
Examination of ears and hearing
13.9
49.3
91
97
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
47.3
44
*
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
438.2
39.1
38
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
214.5
36.8
37
*
Z97.4
ICD-10 Finland
Presence of external hearing-aid
53.7
34.9
41
9
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
29.1
34.1
46
19
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
85.6
33.8
37
5
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
194.5
33.6
34
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
46.8
33.2
40
10
H66.9
ICD-10 Finland
Otitis media, unspecified
15.9
31.9
53
41
H65.3
ICD-10 Finland
Chronic mucoid otitis media
49.1
31.9
38
9
H66.0
ICD-10 Finland
Acute suppurative otitis media
14.8
29.3
50
41
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
28.7
27
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
28.7
27
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
313.2
28.3
28
*
DEB30
NOMESCO Finland
Radical mastoidectomy
+∞
27.6
26
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
26.5
25
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
26.5
25
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
100.0
25.2
27
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
275.2
25.1
25
*
DAX08
NOMESCO Finland
Fitting of hearing aid
62.3
24.6
28
5
DCD00
NOMESCO Finland
Myringoplasty
91.8
23.1
25
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
68.7
22.3
25
*
TDA90
NOMESCO Finland
Removal wax from ear
65.7
21.3
24
*
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
+∞
21.1
20
*
Z97.8
ICD-10 Finland
Presence of other specified devices
+∞
21.1
20
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
119.6
20.9
22
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
227.3
20.9
21
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
227.3
20.9
21
*
S02CA02
ATC
flumetasone and antiinfectives; otic
9.1
20.3
44
57
H95.9
ICD-10 Finland
Postprocedural disorder of ear and mastoid process, unspecified
+∞
20.0
19
*
DCD10
NOMESCO Finland
Tympanoplasty
113.7
19.9
21
*
DFF15
NOMESCO Finland
Speech audiometry
20.2
19.6
29
16
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
15.1
18.8
31
23
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
19.4
18.7
28
16
DC1AD
NOMESCO Finland
Temporalbone CT
71.8
18.0
20
*
WX704
NOMESCO Finland
Intubation
6.1
17.5
50
97
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
181.0
16.7
17
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.1
16.7
56
132
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
+∞
15.8
15
*
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
+∞
15.8
15
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
7.1
15.3
38
61
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
147.3
13.6
14
*
WX720
NOMESCO Finland
Own respiration
7.5
13.1
31
46
Z98.8
ICD-10 Finland
Other specified postsurgical states
20.4
13.1
19
10
H65.2
ICD-10 Finland
Chronic serous otitis media
24.0
13.1
18
8
4151
FHL
Reoperation for chronic otitis media
+∞
12.6
12
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.6
12.4
147
867
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
19.2
12.2
18
10
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
20.1
11.7
17
9
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
68.1
11.7
13
*
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
125.2
11.5
12
*
WX725
NOMESCO Finland
Noninvasive ventilation
6.1
11.5
31
56
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
18.1
11.3
17
10
H60.4
ICD-10 Finland
Cholesteatoma of external ear
45.3
11.0
13
*
H69.0
ICD-10 Finland
Patulous Eustachian tube
62.6
10.7
12
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.3
10.5
32
67
Z01.8
ICD-10 Finland
Other specified special examinations
2.8
10.4
76
330
H92.0
ICD-10 Finland
Otalgia
7.8
10.2
23
32
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
9.7
10.2
20
22
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.6
10.2
89
431
WX702
NOMESCO Finland
Supraglottic ventilation device
5.8
9.7
27
51
ZZG00
NOMESCO Finland
Graft of cartilage
103.6
9.5
10
*
H93.1
ICD-10 Finland
Tinnitus
10.1
9.4
18
19
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
9.4
9
*
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
9.4
9
*
H60.3
ICD-10 Finland
Other infective otitis externa
10.6
9.2
17
17
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
9.0
61
251
H73.1
ICD-10 Finland
Chronic myringitis
92.9
8.5
9
*
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
+∞
8.4
8
*
H66.2
ICD-10 Finland
Chronic atticoantral suppurative otitis media
+∞
8.4
8
*
J01DA09
ATC
[U] cefadroxil; inhalant, oral
2.4
8.4
83
424
H60.8
ICD-10 Finland
Other otitis externa
8.9
7.9
16
19
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
82.3
7.5
8
*
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
82.3
7.5
8
*
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
82.3
7.5
8
*
H91.1
ICD-10 Finland
Presbycusis
6.9
7.2
17
26
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
6.9
7.2
17
26
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.1
7.1
106
644
J01DA06
ATC
[U] cefuroxime; systemic
2.8
7.0
45
179
SPAT1301
SPAT
No procedures
2.1
6.6
97
582
R5120
NOMESCO Finland
Preparation of an aid
10.4
6.6
12
12
J01DA01
ATC
[U] cefalexin; systemic
2.0
6.5
161
1176
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.8
6.4
17
31
DED00
NOMESCO Finland
Obliteration of cavity after partial excision of mastoid
+∞
6.3
6
*
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
+∞
6.3
6
*
J01MA02
ATC
ciprofloxacin; systemic
2.0
6.3
114
740
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
6.1
65
337
H65.0
ICD-10 Finland
Acute serous otitis media
10.4
6.1
11
11
SPAT1097
SPAT
Recording of ECG
2.4
6.1
52
242

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
86
255
4.38
26.78
2.3
1.7
—
—
—
0
0
47
140
3.82
13.99
6.7
8.3
—
—
—
0
0
53
196
3.09
11.16
4.2
4.7
—
—
—
0
0
63
269
2.72
10.16
1.7
1.4
—
—
—
0
0
62
312
2.26
6.86
5.8
7.3
2.5
1.3
mmol/l
1.71
47
244
54
983
0.45
6.79
8.4
9.5
0.0
0.0
e9/l
1.48
45
813
84
486
2.03
6.46
5.5
4.0
23.1
283.3
ng/l
2.56
75
399
61
313
2.20
6.41
5.7
7.2
5.0
5.1
kpa
0.44
56
300
10
17
6.06
5.66
2.0
2.2
—
—
—
0
0
104
701
1.76
4.78
4.0
3.2
7.2
7.3
mmol/l
0.06
91
586
137
1011
1.68
4.44
11.3
10.3
1.5
1.3
inr
0.54
30
288
58
335
1.92
4.35
2.4
1.9
—
—
—
0
0
229
1960
1.82
4.10
23.2
17.4
39.8
39.8
%
0.05
123
1324
101
723
1.61
3.51
3.3
4.1
10.7
12.2
mg/mmol
0.12
53
457
95
683
1.58
3.19
3.0
3.3
49.2
224.2
mg/l
0.93
49
458
45
708
0.57
3.07
3.7
3.2
0.5
0.4
e6/l
0.09
36
532
9
21
4.39
3.02
1.2
1.9
—
—
—
0
0
51
771
0.59
2.98
3.5
3.2
15.6
73.0
e6/l
2.47
43
596
23
113
2.13
2.70
2.7
2.4
—
—
—
0
0
9
24
3.84
2.69
1.4
1.4
—
—
—
0
0
9
24
3.84
2.69
1.4
1.4
—
—
—
0
0
9
24
3.84
2.69
1.4
1.4
—
—
—
0
0
9
24
3.84
2.69
1.4
1.4
—
—
—
0
0
8
210
0.36
2.67
2.5
3.1
1.2
1.2
mmol/l
—
8
184
97
726
1.51
2.65
3.0
2.4
48.1
55.8
u/l
1.91
92
675
211
1845
1.54
2.65
26.9
20.9
332.3
331.7
g/l
0.47
211
1832
83
602
1.53
2.62
1.7
1.7
1.4
1.3
mmol/l
0.37
75
504
46
690
0.60
2.55
3.4
3.1
—
—
—
0
0
8
205
0.37
2.54
7.0
3.7
—
—
—
0
0
31
515
0.55
2.52
3.1
3.0
0.7
0.8
ug/l
0.27
20
351
233
2093
1.59
2.49
4.6
4.6
2.1
1.9
mu/l
0.78
213
1862
196
1699
1.48
2.47
3.6
3.8
14.8
14.9
pmol/l
0.31
183
1507
187
1609
1.46
2.42
6.0
4.4
—
—
—
0
0
29
485
0.55
2.41
2.6
2.8
2.5
2.5
mmol/l
0.35
21
431
47
689
0.62
2.35
2.9
3.1
—
—
—
0
0
38
586
0.60
2.34
3.9
3.9
90.0
87.7
%
0.24
38
576
147
1215
1.43
2.33
7.0
6.8
1.2
1.2
mmol/l
0.28
132
1016
165
1394
1.43
2.31
5.1
4.7
6.9
6.7
mmol/l
0.35
151
1316
71
513
1.51
2.26
4.7
4.1
1.0
1.0
kg/l
0.14
21
78
10
36
2.84
2.22
1.0
1.3
0.3
0.7
g/l
—
5
31
252
2331
1.65
2.10
21.5
14.5
—
—
—
0
0
66
882
0.67
2.10
3.4
3.8
23.3
167.4
e6/l
1.17
45
632
239
2185
1.55
2.09
5.0
4.8
6.0
6.0
mmol/l
0.39
228
1960
91
702
1.43
2.06
4.4
4.4
—
—
—
0
0
53
735
0.66
2.02
2.5
2.5
—
—
—
0
0
7
21
3.39
1.97
1.1
1.2
—
—
—
0
0
34
213
1.68
1.96
1.7
1.6
—
—
—
0
0
10
223
0.43
1.94
1.5
1.4
—
—
—
0
0
135
1125
1.38
1.93
5.2
5.7
1.2
1.2
mmol/l
0.19
123
1016
34
514
0.62
1.91
3.1
2.9
498.2
557.9
mosm/kgh2o
0.91
27
433
13
251
0.50
1.72
1.0
1.3
—
—
—
0
0
28
422
0.63
1.55
1.3
1.4
2.6
2.4
g/l
0.18
17
246
69
532
1.39
1.54
1.5
1.8
232258439.8
12984475.8
pmol/l
0.73
62
439
118
990
1.33
1.53
2.1
2.0
89.7
93.6
pmol/l
0.46
65
504
7
27
2.63
1.52
1.4
1.3
—
—
—
0
0
6
21
2.90
1.51
1.0
1.2
—
—
—
0
0
229
2116
1.40
1.51
6.1
6.1
40.2
40.4
mmol/mol
0.10
214
1948
124
1054
1.31
1.45
5.8
4.4
34.2
35.1
g/l
0.97
111
993
43
581
0.69
1.40
4.6
6.8
—
—
—
0
0
11
208
0.51
1.39
9.8
8.4
—
—
—
0
0
9
44
2.08
1.28
1.4
1.3
—
—
—
0
0
49
634
0.73
1.23
6.2
4.1
0.0
0.0
estimate
—
6
209
175
1578
1.28
1.22
5.7
4.6
—
3935.8
—
0
30
0
33
0.00
1.17
0.0
2.4
—
—
—
0
0
42
552
0.72
1.16
2.5
2.5
3.8
4.9
e6/l
0.64
35
489
0
35
0.00
1.16
0.0
1.2
—
—
—
0
0
183
1670
1.26
1.11
5.0
4.1
15.0
13.3
mm/h
0.72
172
1510
108
931
1.26
1.07
3.3
4.0
122.6
39.7
ng/l
0.39
72
706
70
841
0.78
1.03
2.6
3.4
2.3
2.3
mmol/l
0.03
60
742
61
491
1.31
1.03
1.7
1.8
1003.6
1224.0
nmol/l
1.51
50
370
251
2395
1.37
1.01
11.4
10.6
24.5
25.0
u/l
0.25
241
2303
99
1137
0.80
0.99
5.8
5.1
0.0
0.0
estimate
—
6
217
88
750
1.25
0.95
4.4
5.5
—
—
—
0
0
91
779
1.25
0.94
4.5
3.2
—
—
—
0
0
6
27
2.25
0.94
2.8
2.8
33.8
3.4
nmol/l
—
6
27
59
714
0.78
0.92
4.3
4.1
—
—
—
0
0
89
763
1.24
0.91
3.2
3.6
7.4
7.4
ph
—
6
145
14
212
0.64
0.83
7.9
7.0
1.4
1.4
mmol/l
0.04
14
203
52
628
0.79
0.79
4.1
3.5
—
—
—
0
0
0
25
0.00
0.79
0.0
1.1
—
—
—
0
0
77
890
0.82
0.79
2.4
2.1
—
—
—
0
0
11
173
0.62
0.78
1.2
2.3
—
—
—
0
0
13
83
1.59
0.76
1.1
1.2
—
—
—
0
0
8
132
0.59
0.75
1.4
1.3
—
35.3
—
0
10
22
159
1.42
0.75
1.4
1.2
—
—
—
0
0
7
40
1.77
0.72
1.6
2.7
66.6
63.9
%
—
7
40
23
305
0.73
0.70
1.3
1.3
—
—
—
0
0
104
1157
0.84
0.70
4.6
3.8
0.0
0.0
estimate
—
7
213
26
338
0.75
0.70
1.4
1.3
1.6
11.4
u/ml
—
5
123
228
2184
1.21
0.63
4.7
4.5
4.5
4.5
mmol/l
0.07
211
1983
234
2249
1.22
0.61
5.4
5.1
2.6
2.6
mmol/l
0.18
215
2025
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
7
115
0.60
0.59
2.9
4.0
23.6
24.0
mmol/l
—
7
108
39
469
0.81
0.58
1.4
1.2
4.2
1.6
u/ml
—
9
116
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
40
477
0.81
0.56
5.6
4.9
—
—
—
0
0
234
2256
1.20
0.55
20.0
15.6
24.5
25.2
mg/l
0.12
198
1818
9
60
1.52
0.55
1.6
2.0
—
—
—
0
0
6
39
1.55
0.53
1.7
2.6
—
—
—
0
0
170
1602
1.15
0.53
4.7
4.1
—
—
—
0
0
9
133
0.67
0.53
4.3
7.2
24.1
24.9
mmol/l
—
9
133
66
581
1.18
0.51
2.3
2.7
372.3
6361.9
umol/l
2.18
59
491
9
65
1.40
0.51
1.8
1.7
—
—
—
0
0
14
189
0.73
0.50
2.3
2.9
4.5
4.5
kpa
0.04
14
178
29
352
0.80
0.48
1.4
1.3
17.8
37.2
iu/ml
1.47
13
114
123
1317
0.88
0.45
8.5
9.1
4.4
4.2
e9/l
0.47
115
1157
22
175
1.28
0.45
1.6
1.5
—
—
—
0
0
187
1786
1.13
0.44
8.0
7.5
83.3
78.6
u/l
0.47
178
1670
115
1067
1.13
0.43
5.3
4.1
—
—
—
0
0
8
57
1.41
0.42
1.0
1.1
—
—
—
0
0
5
33
1.52
0.41
1.6
1.9
8.8
115.6
u/ml
—
5
33
5
33
1.52
0.41
1.2
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
27
224
1.23
0.40
3.4
3.0
77.9
68.3
e9/l
0.70
21
176
55
488
1.16
0.40
1.7
1.8
1.8
1.4
mg/l
0.37
41
380
5
36
1.40
0.38
1.2
1.3
—
—
—
0
0
10
73
1.38
0.35
6.1
12.5
—
—
—
0
0
223
2168
1.13
0.34
4.6
4.5
1.4
1.5
mmol/l
1.38
206
1951
16
197
0.80
0.32
1.7
1.5
—
—
—
0
0
7
52
1.35
0.31
2.9
3.0
0.7
1.0
nmol/l
—
7
40
52
572
0.89
0.29
1.2
1.4
—
—
—
0
0
9
118
0.76
0.28
2.8
3.1
—
—
—
0
0
5
71
0.70
0.26
3.6
3.5
—
—
—
0
0
12
147
0.81
0.24
1.4
1.4
—
—
—
0
0
10
125
0.79
0.23
1.5
1.3
—
—
—
0
0
5
40
1.25
0.22
1.4
1.1
0.9
0.9
nmol/l
—
5
32
25
283
0.87
0.22
1.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
117.8
—
0
11
0
11
0.00
0.21
0.0
1.1
—
38.6
—
0
6
0
11
0.00
0.21
0.0
2.3
—
2246.8
—
0
11
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
11.6
—
1363.3
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
9.7
—
—
—
0
0
0
10
0.00
0.21
0.0
8.7
—
784.3
—
0
10
0
12
0.00
0.21
0.0
1.0
—
5.2
—
0
12
0
12
0.00
0.21
0.0
4.3
—
—
—
0
0
20
229
0.86
0.21
2.3
4.0
5.5
5.8
kpa
0.79
20
220
33
364
0.89
0.20
40.0
23.5
—
1.3
—
0
48
9
114
0.78
0.20
5.3
4.5
—
—
—
0
0
118
1133
1.07
0.20
5.3
5.8
0.2
0.2
e9/l
0.06
109
991
36
328
1.11
0.19
2.2
2.4
21.9
22.3
%
0.04
14
285
6
52
1.16
0.19
1.2
1.3
—
—
—
0
0
7
60
1.17
0.18
2.0
2.6
30.6
35.1
umol/l
—
7
52
13
110
1.19
0.17
1.8
4.5
—
—
—
0
0
13
152
0.85
0.17
1.5
1.6
—
—
—
0
0
12
140
0.85
0.15
1.1
1.2
27.5
158.3
iu/ml
—
7
50
7
88
0.79
0.14
3.1
4.2
4.0
3.9
mmol/l
—
7
79
60
632
0.94
0.14
2.3
2.0
2.3
3.2
mg/l
3.13
53
534
19
212
0.89
0.14
1.3
2.5
62.5
66.3
g/l
1.22
19
188
116
1127
1.05
0.12
5.3
5.6
1.8
1.9
e9/l
0.54
108
990
211
2082
1.05
0.11
3.9
4.0
1.3
1.3
mmol/l
0.63
195
1859
85
877
0.96
0.10
4.9
5.2
7.5
2.4
ug/l
0.48
73
760
21
228
0.91
0.10
2.2
4.0
2.8
1.9
mmol/l
0.55
16
182
15
166
0.90
0.10
4.6
2.5
—
—
—
0
0
5
44
1.14
0.10
5.2
2.9
9.2
8.3
kpa
—
5
44
5
47
1.06
0.09
1.2
1.4
69.8
65.1
mmol/l
—
5
42
13
116
1.13
0.09
2.2
2.7
1.4
1.2
%
0.70
13
116
113
1105
1.04
0.09
5.3
5.5
0.0
0.0
e9/l
0.64
106
953
51
531
0.95
0.09
4.9
3.8
—
—
—
0
0
6
56
1.07
0.08
1.5
1.2
—
—
—
0
0
12
107
1.13
0.08
1.3
1.4
—
—
—
0
0
13
144
0.90
0.08
1.5
1.4
—
—
—
0
0
28
264
1.07
0.08
1.5
1.5
—
—
—
0
0
6
72
0.83
0.07
1.2
2.6
20.9
25.5
mmol/l
—
6
59
10
112
0.89
0.07
1.3
3.1
15.1
41.8
u/ml
—
10
107
31
326
0.95
0.07
1.5
1.7
—
—
—
0
0
8
93
0.86
0.07
4.1
4.7
—
—
—
0
0
76
744
1.03
0.05
2.2
2.1
702.7
229.9
u/l
0.64
71
696
111
1100
1.01
0.02
5.4
5.5
0.6
0.6
e9/l
0.17
104
940
16
167
0.96
0.01
2.0
2.7
8.4
10.8
g/l
2.45
16
148
60
608
0.98
0.01
1.5
1.5
17.9
20.8
nmol/l
0.76
54
503
25
244
1.03
0.00
1.8
2.0
97.4
144.9
ug/g
0.63
20
187
23
232
0.99
0.00
2.1
4.1
—
—
—
0
0
13
131
0.99
0.00
1.0
1.5
0.6
1.4
g/l
2.98
13
121
113
1134
0.99
0.00
4.4
3.8
0.0
0.0
estimate
—
6
221
15
147
1.02
0.00
1.1
1.3
—
—
—
0
0
21
207
1.02
0.00
3.1
3.5
96.3
85.7
ng/l
0.27
21
183
24
237
1.01
0.00
3.5
4.7
—
—
—
0
0
14
135
1.04
0.00
1.1
1.3
—
—
—
0
0
21
215
0.97
0.00
1.3
1.5
—
—
—
0
0
5
58
0.86
0.00
25.4
1.4
—
—
—
0
0
5
58
0.86
0.00
25.4
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
0.00
26.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
1.8
—
0
6
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
8
88
0.91
0.00
3.0
1.9
—
—
—
0
0
5
55
0.91
0.00
1.4
3.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
11.3
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
0.00
4.0
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
4.1
—
54.8
—
0
9
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
0.00
4.8
1.4
—
—
—
0
0
5
54
0.92
0.00
25.4
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
19
190
1.00
0.00
5.4
3.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
7.8
—
—
—
0
0
5
55
0.91
0.00
2.6
2.0
142.2
127.9
g/l
—
5
39
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H8_POSTOP and mortality.

Females

Parameter HR [95% CI] p-value
H8_POSTOP 1.144 [0.98, 1.33] 0.082
Birth year 0.996 [0.99, 1.0] 0.295

During the follow-up period (1.1.1998 — 31.12.2019), 277 out of 1246 females with H8_POSTOP died.

Males

Parameter HR [95% CI] p-value
H8_POSTOP 1.039 [0.89, 1.21] 0.623
Birth year 0.989 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 310 out of 1325 males with H8_POSTOP died.

Mortality risk

Mortality risk for people of age

years, who have H8_POSTOP.

N-year risk Females Males
1 0.115% 0.218%
5 0.677% 1.277%
10 1.588% 3.284%
15 3.028% 6.119%
20 5.623% 10.166%

Relationships between endpoints

↥

Index endpoint: H8_POSTOP – Postprocedural disorders of ear and mastoid process, not elsewhere classified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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