No definition available.
Recurrent cholesteatoma of postmastoidectomy cavity
H8_POSTMASTCHOLEASTOMA
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
110 |
4. Check minimum number of eventsNone |
110 |
5. Include endpointsNone |
110 |
6. Filter based on genotype QC (FinnGen only) |
105 |
Control definitions (FinnGen only)
- Control exclude
- H8_OTHEREAR
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H95
- Name in latin
- Cholesteatoma postoperativum recidivum auris mediae
Similar endpoints
↥List of similar endpoints to
Recurrent cholesteatoma of postmastoidectomy cavity
based on the number of shared cases.
Similar with more cases:
- Postprocedural disorders of ear and mastoid process, not elsewhere classified
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1043 | 467 | 574 |
| Only index persons | 986 | 440 | 546 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 55.47 | 58.07 | 53.39 |
| Only index persons | 54.74 | 57.43 | 52.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 105 | 44 | 61 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 57.41 | 56.98 | 57.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 110
- Matched controls
- 1100
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
+∞
158.7
110
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
2502.7
94.7
78
*
UDC00
NOMESCO Finland
Ear microscopy
43.9
77.2
52
22
Z01.1
ICD-10 Finland
Examination of ears and hearing
18.8
41.4
38
30
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
72.3
31.6
35
7
DFF00
NOMESCO Finland
Pure tone audiometry
43.8
29.6
36
12
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
26.1
24
*
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
23.8
22
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
23.8
22
*
DEB30
NOMESCO Finland
Radical mastoidectomy
271.9
22.5
22
*
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
21.6
20
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
7.8
18.6
31
53
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
18.2
17
*
Z97.4
ICD-10 Finland
Presence of external hearing-aid
212.9
18.1
18
*
DCD10
NOMESCO Finland
Tympanoplasty
212.9
18.1
18
*
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
17.1
16
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
17.1
16
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
48.2
17.0
20
5
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
56.8
16.6
19
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
+∞
16.0
15
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
92.8
15.0
16
*
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
+∞
14.9
14
*
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
171.9
14.8
15
*
DFF15
NOMESCO Finland
Speech audiometry
85.7
14.0
15
*
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
+∞
13.8
13
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
13.8
13
*
Z3229
NOMESCO Finland
Other healthcare associate professional
6.8
13.0
23
41
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
+∞
12.7
12
*
DAX08
NOMESCO Finland
Fitting of hearing aid
146.0
12.7
13
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
7.2
12.7
21
35
ZXE20
NOMESCO Finland
More than three and less than five hours
4.9
12.6
36
100
DCD00
NOMESCO Finland
Myringoplasty
+∞
11.7
11
*
H66.9
ICD-10 Finland
Otitis media, unspecified
10.5
10.9
21
24
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
66.6
10.9
12
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
121.1
10.6
11
*
DC1AD
NOMESCO Finland
Temporalbone CT
60.5
9.8
11
*
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
109.0
9.6
10
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
109.0
9.6
10
*
4151
FHL
Reoperation for chronic otitis media
+∞
9.5
9
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
+∞
9.5
9
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
54.4
8.8
10
*
R5120
NOMESCO Finland
Preparation of an aid
30.2
8.7
11
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
30.2
8.7
11
*
ZZG00
NOMESCO Finland
Graft of cartilage
+∞
8.4
8
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
8.4
8
*
H60.4
ICD-10 Finland
Cholesteatoma of external ear
+∞
8.4
8
*
S02CA02
ATC
flumetasone and antiinfectives; otic
7.7
8.3
19
29
R5140
NOMESCO Finland
Monitoring the use of the aid
4.7
8.0
21
53
WZC00, ,
SPAT
4.9
7.5
18
42
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
+∞
7.4
7
*
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
7.4
7
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
32.4
7.3
9
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
42.8
6.8
8
*
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
42.8
6.8
8
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
6.1
6.8
18
34
WX704
NOMESCO Finland
Intubation
5.8
6.5
18
36
ZXA05
NOMESCO Finland
Left side
2.9
6.4
41
187
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
6.3
39
174
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
67
2.62
2.78
2.5
1.6
—
—
—
0
0
20
102
2.17
2.28
6.4
7.2
1.35
1.43
mmol/l
0.03
13
82
0
58
0.00
2.11
0.0
3.0
—
4.43
—
0
48
50
361
1.71
1.98
6.0
4.3
33.60
35.52
g/l
1.16
44
342
91
791
1.87
1.69
5.5
6.0
39.78
40.28
mmol/mol
0.21
86
736
95
845
1.91
1.53
5.2
5.2
2.61
2.66
mmol/l
0.22
85
766
93
822
1.85
1.52
4.5
4.6
4.49
4.54
mmol/l
0.20
85
756
89
779
1.75
1.48
3.5
4.5
1.84
1.93
mu/l
0.30
82
694
56
440
1.56
1.46
7.7
6.1
10.62
11.47
umol/l
0.39
56
421
18
105
1.85
1.44
1.8
1.7
—
—
—
0
0
53
417
1.52
1.35
24.8
15.3
1.25
1.31
inr
0.13
11
125
101
930
2.05
1.32
25.4
21.8
39.83
40.44
%
0.41
78
880
53
419
1.51
1.31
6.2
6.5
1.21
1.21
mmol/l
0.05
44
358
18
109
1.78
1.28
1.6
1.7
—
—
—
0
0
13
73
1.89
1.16
6.6
7.4
9.63
9.37
mmol/l
0.06
13
68
91
818
1.65
1.16
4.2
4.5
1.42
1.44
mmol/l
0.26
84
740
22
146
1.63
1.14
1.8
1.9
—
—
—
0
0
60
502
1.43
1.04
5.1
4.8
6.63
6.77
mmol/l
0.35
55
472
87
790
1.48
0.89
3.7
4.1
1.27
1.27
mmol/l
0.00
81
712
6
31
1.99
0.86
2.5
2.5
—
—
—
0
0
8
46
1.80
0.84
1.9
3.0
1.34
1.02
%
—
8
46
0
25
0.00
0.80
0.0
2.4
—
144.01
—
0
15
63
549
1.35
0.77
4.3
2.8
55.11
51.05
u/l
0.16
56
513
58
502
1.33
0.73
2.7
2.8
—
—
—
0
0
5
28
1.82
0.67
3.6
2.3
—
—
—
0
0
6
101
0.57
0.66
2.7
3.1
—
—
—
0
0
34
276
1.34
0.65
2.5
3.3
1083.03
1296.69
ng/l
0.25
26
229
0
20
0.00
0.61
0.0
1.3
—
—
—
0
0
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
5
88
0.55
0.59
2.2
2.7
15.20
5.64
ug/l
—
5
79
33
271
1.31
0.58
3.6
3.9
24.18
8.90
mg/mmol
0.59
17
173
23
181
1.34
0.54
4.9
4.6
1.02
1.02
kg/l
0.39
11
22
6
40
1.53
0.52
1.5
2.2
—
—
—
0
0
74
794
0.79
0.48
16.6
13.9
78.10
79.53
ml/min/173m2
0.21
61
659
32
270
1.26
0.46
4.3
4.6
23.48
21.61
%
0.33
13
128
0
16
0.00
0.41
0.0
4.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
5
35
1.45
0.40
1.4
2.0
—
—
—
0
0
89
847
1.27
0.38
18.5
14.9
26.52
24.07
mg/l
0.24
75
666
38
335
1.21
0.36
2.0
2.0
80.84
89.24
pmol/l
0.72
20
170
42
376
1.19
0.34
3.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
2.90
—
0
7
21
237
0.86
0.20
7.0
4.3
0.00
0.00
estimate
—
5
78
6
51
1.19
0.20
1.7
1.3
—
—
—
0
0
17
195
0.85
0.19
2.4
2.3
—
—
—
0
0
15
129
1.19
0.18
2.7
2.3
2.69
2.31
g/l
1.14
15
113
5
65
0.76
0.17
1.8
1.7
—
—
—
0
0
13
111
1.19
0.16
9.5
6.4
105.23
103.50
mmol/l
0.43
13
111
30
324
0.90
0.15
6.5
4.2
—
—
—
0
0
17
151
1.15
0.14
2.0
2.6
1.00
0.95
e6/l
0.05
12
90
39
413
0.91
0.13
6.5
5.2
0.00
0.00
estimate
—
5
84
13
145
0.88
0.10
3.8
3.1
0.81
0.82
mmol/l
0.14
13
135
11
123
0.88
0.08
1.7
1.4
—
—
—
0
0
15
137
1.11
0.08
2.9
2.5
12.05
12.27
umol/l
0.05
15
124
19
204
0.92
0.07
3.2
3.0
0.66
0.80
ug/l
—
10
130
7
81
0.86
0.07
2.6
3.4
1.22
1.23
mmol/l
—
7
73
9
86
1.05
0.07
1.9
1.9
—
—
—
0
0
33
316
1.06
0.06
4.2
3.0
—
—
—
0
0
43
416
1.06
0.06
5.1
4.0
0.00
0.01
estimate
—
5
90
15
140
1.08
0.04
2.2
3.0
1.81
2.55
e6/l
—
10
80
10
91
1.11
0.04
1.1
1.8
1.33
1.66
%
—
10
76
10
108
0.92
0.03
2.3
3.3
324.20
242.36
u/l
—
10
102
13
122
1.07
0.03
2.9
2.4
17.65
20.92
%
—
8
105
34
347
0.97
0.01
3.3
4.2
325.70
42.47
ng/l
0.43
23
257
28
282
0.99
0.00
3.5
3.3
2.37
2.36
mmol/l
0.24
22
245
42
422
0.99
0.00
5.2
3.9
0.00
0.00
estimate
—
5
81
16
164
0.97
0.00
2.9
2.8
2.48
2.46
mmol/l
—
9
140
26
256
1.02
0.00
3.8
2.8
0.29
0.45
e6/l
0.45
20
197
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
12.93
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
6.20
—
0
5
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
1.17
—
0
5
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
11
110
1.00
-0.00
1.2
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.4
—
99.09
—
0
8
10
100
1.00
-0.00
2.8
8.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
77
0.90
-0.00
2.6
2.2
12.24
13.83
nmol/l
—
7
68
7
76
0.92
-0.00
5.7
3.8
135.00
84.30
ng/l
—
7
68
0
7
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
7
79
0.88
-0.00
1.9
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_POSTMASTCHOLEASTOMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTMASTCHOLEASTOMA | 0.987 [0.78, 1.24] | 0.91 |
| Birth year | 0.991 [0.98, 1.0] | 0.042 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 423 females with H8_POSTMASTCHOLEASTOMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTMASTCHOLEASTOMA | 1.045 [0.85, 1.29] | 0.679 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 516 males with H8_POSTMASTCHOLEASTOMA died.
Mortality risk
Mortality risk for people of age
years, who have H8_POSTMASTCHOLEASTOMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.199% |
| 5 | 0.516% | 1.236% |
| 10 | 1.229% | 2.987% |
| 15 | 2.24% | 5.244% |
| 20 | 3.872% | 9.083% |
Relationships between endpoints
↥Index endpoint: H8_POSTMASTCHOLEASTOMA – Recurrent cholesteatoma of postmastoidectomy cavity
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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