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Recurrent cholesteatoma of postmastoidectomy cavity

DOID Endpoint Browser PheWeb

H8_POSTMASTCHOLEASTOMA

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H95.0
  • Cause of death: ICD-10 — H95.0

2 out of 7 registries used, show all original rules.

107

4. Check minimum number of events

None

107

5. Include endpoints

None

107

6. Filter based on genotype QC (FinnGen only)

107

Control definitions (FinnGen only)

Control exclude
H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H95
Name in latin
Cholesteatoma postoperativum recidivum auris mediae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1043 467 574
Only index persons 986 440 546
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 55.47 58.07 53.39
Only index persons 54.74 57.43 52.57

-FinnGen-

Key figures

All Female Male
Number of individuals 107 47 60
Unadjusted period prevalence (%) 0.02 0.02 0.03
Median age at first event (years) 57.63 57.10 58.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
104
Matched controls
1039
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
+∞
149.9
104
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
1075.3
83.7
71
*
UDC00
NOMESCO Finland
Ear microscopy
49.2
41.5
50
19
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
90.9
29.9
32
5
Z01.1
ICD-10 Finland
Examination of ears and hearing
19.1
23.6
37
29
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
22.7
21
*
DEB30
NOMESCO Finland
Radical mastoidectomy
+∞
21.6
20
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
21.6
20
*
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
21.6
20
*
DFF00
NOMESCO Finland
Pure tone audiometry
25.5
19.5
27
14
DCD10
NOMESCO Finland
Tympanoplasty
+∞
19.4
18
*
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
18.2
17
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
214.9
18.1
18
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
+∞
16.0
15
*
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
16.0
15
*
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
173.2
14.9
15
*
H70.1
ICD-10 Finland
Chronic mastoiditis
173.2
14.9
15
*
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
13.8
13
*
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
+∞
12.8
12
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
12.8
12
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
22.2
12.0
17
9
Z97.4
ICD-10 Finland
Presence of external hearing-aid
26.6
12.0
16
7
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
134.1
11.7
12
*
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
134.1
11.7
12
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
10.6
10
*
DC1AD
NOMESCO Finland
Temporalbone CT
109.5
9.6
10
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
9.5
9
*
H66.9
ICD-10 Finland
Otitis media, unspecified
9.0
9.1
19
25
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
6.2
9.1
25
50
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
54.7
8.8
10
*
DCD00
NOMESCO Finland
Myringoplasty
97.5
8.5
9
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
+∞
8.4
8
*
H60.4
ICD-10 Finland
Cholesteatoma of external ear
+∞
8.4
8
*
ZZG00
NOMESCO Finland
Graft of cartilage
+∞
8.4
8
*
4151
FHL
Reoperation for chronic otitis media
+∞
8.4
8
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
8.5
8.4
18
25
H66.0
ICD-10 Finland
Acute suppurative otitis media
8.6
8.1
17
23
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
48.7
7.8
9
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
48.7
7.8
9
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
20.2
7.8
11
6
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
27.3
7.7
10
*
H61.2
ICD-10 Finland
Impacted cerumen
9.0
7.4
15
19
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
7.4
7
*
S02CA02
ATC
flumetasone and antiinfectives; otic
6.6
7.2
18
32
ZXA05
NOMESCO Finland
Left side
3.4
7.1
41
167
R5120
NOMESCO Finland
Preparation of an aid
42.9
6.9
8
*
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
42.9
6.9
8
*
DFF15
NOMESCO Finland
Speech audiometry
15.6
6.5
10
7
WX704
NOMESCO Finland
Intubation
6.1
6.5
17
32
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
+∞
6.3
6
*
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
6.3
6
*
M95.0
ICD-10 Finland
Acquired deformity of nose
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
28
93
3.72
7.44
2.1
1.6
—
—
—
0
0
14
37
4.20
4.99
8.0
8.1
—
—
—
0
0
17
64
2.97
3.60
3.5
4.4
—
—
—
0
0
25
123
2.35
3.14
2.0
1.8
—
—
—
0
0
51
349
1.88
2.61
11.7
8.7
1.3
1.3
inr
0.07
11
105
20
99
2.25
2.46
6.4
7.3
1.4
1.3
mmol/l
0.00
13
80
19
96
2.19
2.22
1.4
1.5
—
—
—
0
0
6
15
4.17
2.07
1.2
2.2
67.5
63.6
%
—
6
15
50
361
1.72
2.01
6.0
4.3
33.6
35.5
g/l
1.17
44
342
37
247
1.76
1.94
4.5
4.4
—
—
—
0
0
97
857
2.41
1.94
18.1
14.1
—
—
—
0
0
8
30
2.80
1.76
4.3
13.2
—
—
—
0
0
70
566
1.68
1.76
5.6
4.3
—
—
—
0
0
88
759
1.90
1.75
3.5
4.4
1.8
1.9
mu/l
0.32
82
674
14
73
2.06
1.52
2.0
1.5
—
—
—
0
0
83
720
1.68
1.41
23.5
16.0
39.1
40.2
%
0.46
45
517
90
799
1.80
1.39
4.5
4.6
4.5
4.5
mmol/l
0.33
83
732
92
822
1.85
1.39
5.3
5.2
2.6
2.7
mmol/l
0.34
83
742
5
17
3.03
1.37
1.4
2.2
—
—
—
0
0
55
437
1.53
1.35
7.8
6.2
10.6
11.5
umol/l
0.42
55
415
98
904
2.00
1.33
25.2
22.0
132.9
135.6
g/l
1.13
98
889
98
904
2.00
1.33
25.1
21.8
91.0
91.2
fl
0.18
98
890
98
904
2.00
1.33
25.1
21.9
4.4
4.5
e12/l
0.77
98
874
98
904
2.00
1.33
25.1
21.8
30.4
30.3
pg
0.05
98
890
98
904
2.00
1.33
25.2
21.9
250.4
245.1
e9/l
0.40
98
881
13
71
1.95
1.26
6.6
7.5
9.6
9.4
mmol/l
0.05
13
66
5
19
2.71
1.23
5.6
1.3
—
—
—
0
0
98
905
1.98
1.21
25.1
21.9
6.9
6.7
e9/l
0.77
98
877
60
498
1.47
1.13
5.1
4.8
6.6
6.8
mmol/l
0.38
55
469
65
551
1.46
1.07
5.3
4.4
—
632.4
—
0
13
88
795
1.60
1.04
4.2
4.6
1.4
1.4
mmol/l
0.32
82
717
67
575
1.44
1.01
4.1
4.0
—
—
—
0
0
0
28
0.00
0.99
0.0
1.2
—
0.2
—
0
28
32
240
1.48
0.99
4.2
3.1
—
—
—
0
0
17
112
1.62
0.92
1.3
1.6
—
—
—
0
0
6
112
0.51
0.89
1.8
1.3
—
—
—
0
0
8
44
1.88
0.88
1.9
3.0
0.5
0.7
%
—
8
44
8
45
1.84
0.86
1.9
3.1
1.3
1.0
%
—
8
45
14
89
1.66
0.86
1.4
1.2
—
—
—
0
0
20
272
0.67
0.81
3.7
3.2
—
—
—
0
0
0
24
0.00
0.80
0.0
1.9
—
6.6
—
0
6
84
766
1.45
0.80
3.7
4.1
1.3
1.3
mmol/l
0.02
79
690
50
423
1.34
0.75
4.0
5.8
1.8
1.8
e9/l
0.03
45
377
35
280
1.37
0.75
3.8
5.3
—
—
—
0
0
5
27
1.89
0.69
3.6
2.3
—
—
—
0
0
12
78
1.61
0.69
2.5
4.5
—
—
—
0
0
33
267
1.34
0.65
3.6
4.0
24.2
9.1
mg/mmol
0.58
17
167
46
392
1.30
0.63
4.4
5.7
60.6
58.9
%
0.50
46
368
14
97
1.51
0.63
1.2
1.5
—
—
—
0
0
23
178
1.37
0.59
4.9
4.4
1.0
1.0
kg/l
0.25
11
21
46
395
1.29
0.59
4.5
6.0
25.3
26.3
%
0.25
46
365
5
86
0.56
0.59
2.2
2.5
15.2
5.7
ug/l
—
5
77
25
200
1.33
0.53
2.9
2.2
3.7
5.0
e6/l
0.52
20
177
8
58
1.41
0.42
1.3
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.7
—
—
—
0
0
87
826
1.28
0.40
18.8
15.0
26.8
23.5
mg/l
0.34
74
655
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
20
243
0.78
0.39
4.4
4.3
—
—
—
0
0
29
247
1.24
0.38
3.3
3.4
66.4
64.4
mg/l
0.02
18
167
42
374
1.20
0.36
4.7
5.9
0.6
0.6
%
0.27
42
347
43
385
1.20
0.35
4.6
5.8
2.8
2.7
%
0.07
43
358
43
387
1.19
0.33
4.7
6.1
8.4
8.7
%
0.27
43
364
7
97
0.70
0.32
1.4
2.0
109.7
117.0
ug/g
—
7
76
22
258
0.81
0.32
2.7
2.4
—
—
—
0
0
37
330
1.19
0.31
2.0
2.0
80.8
89.9
pmol/l
0.80
20
170
30
265
1.18
0.28
3.3
3.2
7.4
7.4
ph
—
5
57
5
72
0.68
0.27
1.2
1.4
—
—
—
0
0
5
75
0.65
0.26
3.4
3.6
—
—
—
0
0
24
210
1.18
0.24
4.4
3.4
84.3
90.4
%
0.54
24
205
15
126
1.22
0.22
2.7
2.4
2.7
2.3
g/l
1.13
15
111
5
41
1.23
0.22
2.4
2.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
597.2
—
0
5
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
1.5
—
0
6
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
2.8
—
0
5
13
108
1.23
0.21
9.5
6.4
105.2
103.4
mmol/l
0.47
13
102
0
13
0.00
0.21
0.0
3.2
—
4.2
—
0
13
0
13
0.00
0.21
0.0
2.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
75
0.79
0.16
8.8
3.5
—
—
—
0
0
21
233
0.88
0.16
7.0
4.2
0.0
0.0
estimate
—
5
76
18
202
0.87
0.16
3.2
3.1
0.7
0.8
ug/l
—
10
133
29
314
0.90
0.15
2.6
1.9
—
—
—
0
0
15
133
1.15
0.13
2.9
2.5
12.1
12.4
umol/l
0.08
15
120
39
408
0.93
0.09
6.5
5.1
0.0
0.0
estimate
—
5
82
20
185
1.10
0.09
3.6
3.9
—
—
—
0
0
6
55
1.10
0.09
1.7
1.3
—
—
—
0
0
7
63
1.12
0.08
1.9
1.5
—
—
—
0
0
8
75
1.07
0.07
1.0
1.7
62.0
66.5
g/l
—
8
68
7
82
0.84
0.07
2.6
3.3
1.2
1.2
mmol/l
—
7
75
22
234
0.92
0.07
6.4
3.5
—
—
—
0
0
13
119
1.11
0.06
2.9
2.4
17.6
21.3
%
—
8
105
27
281
0.95
0.04
3.6
3.4
2.4
2.4
mmol/l
0.28
22
243
33
320
1.05
0.03
3.9
3.5
29.8
69.1
e6/l
0.87
26
233
13
138
0.93
0.02
3.8
3.2
0.8
0.8
mmol/l
0.14
13
130
26
253
1.04
0.01
3.8
2.8
0.3
0.5
e6/l
0.47
20
192
16
162
0.99
0.00
2.9
2.8
2.5
2.5
mmol/l
—
9
138
34
341
1.00
0.00
3.3
4.1
325.7
43.0
ng/l
0.43
23
252
19
187
1.02
0.00
2.0
4.6
—
—
—
0
0
22
223
0.98
0.00
1.3
1.4
—
—
—
0
0
42
417
1.01
0.00
5.2
3.8
0.0
0.0
estimate
—
5
80
12
119
1.01
0.00
59.8
27.6
—
1.2
—
0
14
5
59
0.84
0.00
1.0
1.4
—
—
—
0
0
8
80
1.00
0.00
1.3
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
22
220
1.00
0.00
5.0
6.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
0.00
2.3
4.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
6.3
—
0
6
6
68
0.88
0.00
14.3
7.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
6.5
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
24
240
1.00
0.00
4.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
6.8
—
0
6
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
236.9
—
0
7
0
5
0.00
0.00
0.0
4.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
14
140
1.00
0.00
1.5
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
7
69
1.02
0.00
5.7
4.0
135.0
86.3
ng/l
—
7
62
7
71
0.98
0.00
2.6
2.3
12.2
13.3
nmol/l
—
7
61
5
55
0.90
0.00
8.4
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
0.00
1.1
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H8_POSTMASTCHOLEASTOMA and mortality.

Females

Parameter HR [95% CI] p-value
H8_POSTMASTCHOLEASTOMA 0.987 [0.78, 1.24] 0.91
Birth year 0.991 [0.98, 1.0] 0.042

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 423 females with H8_POSTMASTCHOLEASTOMA died.

Males

Parameter HR [95% CI] p-value
H8_POSTMASTCHOLEASTOMA 1.045 [0.85, 1.29] 0.679
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 516 males with H8_POSTMASTCHOLEASTOMA died.

Mortality risk

Mortality risk for people of age

years, who have H8_POSTMASTCHOLEASTOMA.

N-year risk Females Males
1 0.117% 0.199%
5 0.516% 1.236%
10 1.229% 2.987%
15 2.24% 5.244%
20 3.872% 9.083%

Relationships between endpoints

↥

Index endpoint: H8_POSTMASTCHOLEASTOMA – Recurrent cholesteatoma of postmastoidectomy cavity

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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