eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
136 |
4. Check minimum number of eventsNone |
136 |
5. Include endpointsNone |
136 |
6. Filter based on genotype QC (FinnGen only) |
136 |
Control definitions (FinnGen only)
- Control exclude
- H8_OTHEREAR
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H95
- Name in latin
- Aliae morbositates post operationem auris mediae
Similar endpoints
↥List of similar endpoints to
Other disorders following mastoidectomy
based on the number of shared cases.
Similar with more cases:
- Postprocedural disorders of ear and mastoid process, not elsewhere classified
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1322 | 658 | 658 |
| Only index persons | 1256 | 626 | 630 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 65.04 | 68.12 | 61.92 |
| Only index persons | 64.61 | 67.69 | 61.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 136 | 67 | 69 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 62.43 | 61.70 | 63.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 118
- Matched controls
- 1180
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
170.3
118
*
UDC00
NOMESCO Finland
Ear microscopy
196.5
91.4
88
17
H71
ICD-10 Finland
Cholesteatoma of middle ear
685.7
71.9
64
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
123.7
39.8
41
5
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
36.3
33
*
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
27.1
25
*
DFF00
NOMESCO Finland
Pure tone audiometry
27.0
25.4
35
18
Z01.1
ICD-10 Finland
Examination of ears and hearing
12.6
21.2
40
46
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
+∞
19.3
18
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
25.2
18.8
26
13
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
18.2
17
*
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
210.1
18.0
18
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
17.1
16
*
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
98.4
16.0
17
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
16.0
15
*
Z97.4
ICD-10 Finland
Presence of external hearing-aid
26.4
14.8
20
9
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
61.0
14.2
16
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
84.8
13.9
15
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
24.8
13.8
19
9
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
13.8
13
*
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
157.2
13.8
14
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
78.5
12.9
14
*
DAX08
NOMESCO Finland
Fitting of hearing aid
28.0
12.9
17
7
TDA90
NOMESCO Finland
Removal wax from ear
144.6
12.7
13
*
Z98.8
ICD-10 Finland
Other specified postsurgical states
34.0
12.0
15
5
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
72.3
11.9
13
*
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
132.3
11.6
12
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
132.3
11.6
12
*
Z97.8
ICD-10 Finland
Presence of other specified devices
+∞
11.6
11
*
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
+∞
11.6
11
*
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
14.9
11.1
18
14
DFF15
NOMESCO Finland
Speech audiometry
21.2
10.6
15
8
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
10.6
10
*
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
+∞
10.6
10
*
WX704
NOMESCO Finland
Intubation
7.3
10.2
25
42
H66.0
ICD-10 Finland
Acute suppurative otitis media
8.2
9.9
22
32
S02CA02
ATC
flumetasone and antiinfectives; otic
8.2
9.9
22
32
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
9.5
9
*
Z01.8
ICD-10 Finland
Other specified special examinations
4.0
9.2
43
149
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
20.6
9.2
13
7
H66.9
ICD-10 Finland
Otitis media, unspecified
9.4
9.0
18
22
H65.2
ICD-10 Finland
Chronic serous otitis media
54.1
8.8
10
*
H93.1
ICD-10 Finland
Tinnitus
22.0
8.7
12
6
DEA10
NOMESCO Finland
Attico-antrotomy
85.1
7.5
8
*
DCD00
NOMESCO Finland
Myringoplasty
85.1
7.5
8
*
WX725
NOMESCO Finland
Noninvasive ventilation
8.9
7.4
15
19
H69.0
ICD-10 Finland
Patulous Eustachian tube
+∞
7.4
7
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.9
7.1
65
352
WX720
NOMESCO Finland
Own respiration
8.7
6.8
14
18
H60.9
ICD-10 Finland
Otitis externa, unspecified
6.9
6.7
16
26
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
13.3
6.7
11
9
DC1AD
NOMESCO Finland
Temporalbone CT
73.6
6.5
7
*
H65.0
ICD-10 Finland
Acute serous otitis media
28.3
6.3
8
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
28.3
6.3
8
*
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
6.3
6
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
+∞
6.3
6
*
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
+∞
6.3
6
*
4151
FHL
Reoperation for chronic otitis media
+∞
6.3
6
*
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
+∞
6.3
6
*
-31
ICPC
Medical examin/health eval partial
4.9
6.1
19
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
32
133
2.84
5.66
2.4
1.6
—
—
—
0
0
31
127
2.87
5.63
2.9
1.6
—
—
—
0
0
38
189
2.40
4.63
2.7
1.7
—
—
—
0
0
21
428
0.40
3.82
2.5
3.2
—
—
—
0
0
27
139
2.18
2.96
4.6
4.7
29.5
33.4
%
1.44
17
76
83
1010
0.54
2.89
11.3
15.3
75.4
75.9
ml/min/173m2
0.06
63
839
27
145
2.08
2.66
5.7
6.0
3.4
1.3
mmol/l
1.76
18
116
84
661
1.71
2.34
2.8
2.9
48.1
48.0
u/l
0.01
74
607
7
20
3.63
2.08
1.3
1.3
—
—
—
0
0
62
464
1.62
2.00
2.1
2.1
89.1
91.5
pmol/l
0.17
36
234
9
38
2.46
1.49
4.2
2.1
—
—
—
0
0
7
29
2.49
1.41
2.4
2.1
—
—
—
0
0
114
1028
1.67
1.39
5.4
4.8
5.9
6.1
mmol/l
1.04
105
917
110
985
1.61
1.36
4.7
4.7
2.0
2.0
mu/l
0.23
98
866
28
386
0.65
1.18
2.3
3.1
2.3
2.4
mmol/l
0.33
23
341
7
136
0.49
1.17
2.0
3.5
—
—
—
0
0
63
519
1.40
1.11
5.1
5.3
1.2
1.2
mmol/l
0.04
57
470
8
149
0.51
1.11
4.7
3.9
371.1
245.6
u/l
—
8
140
90
788
1.42
1.11
3.3
3.8
15.0
14.9
pmol/l
0.27
81
686
109
992
1.50
1.06
6.2
6.3
39.4
40.8
mmol/mol
1.04
99
908
6
117
0.49
0.99
1.5
4.5
5.5
5.8
kpa
—
6
110
0
29
0.00
0.99
0.0
1.2
—
—
—
0
0
0
30
0.00
0.98
0.0
2.9
—
119.3
—
0
18
17
251
0.63
0.97
1.8
2.2
—
—
—
0
0
89
789
1.37
0.95
5.3
4.1
13.4
14.0
mm/h
0.12
81
715
55
457
1.34
0.88
2.1
2.2
83.5
76.8
nmol/l
1.10
50
386
6
31
1.98
0.85
1.3
1.6
—
0.1
—
0
8
18
122
1.55
0.85
1.1
1.4
—
—
—
0
0
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
66
570
1.31
0.79
3.2
2.6
—
—
—
0
0
14
91
1.60
0.79
2.1
1.5
—
—
—
0
0
76
670
1.30
0.78
5.1
4.4
6.9
6.7
mmol/l
0.43
69
635
66
573
1.29
0.75
7.8
5.9
1.2
1.2
mmol/l
0.74
61
481
110
1026
1.38
0.72
4.5
4.6
4.5
4.5
mmol/l
0.12
100
927
32
253
1.35
0.70
1.4
1.9
373.7
417.8
pmol/l
0.72
27
213
45
378
1.28
0.64
3.0
3.3
2009.3
1638.8
ng/l
0.17
38
322
112
1056
1.34
0.61
5.4
5.2
2.6
2.6
mmol/l
0.16
101
942
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
118
1127
1.36
0.52
10.4
10.5
24.2
24.4
u/l
0.07
109
1084
29
236
1.29
0.52
1.4
1.8
803.7
1193.8
nmol/l
2.81
22
180
34
402
0.79
0.51
3.4
4.2
—
—
—
0
0
54
478
1.22
0.48
2.9
4.4
27.3
52.7
ng/l
1.46
31
373
11
150
0.71
0.44
1.5
1.2
—
14.8
—
0
57
12
161
0.72
0.44
1.3
1.2
12.8
45.6
iu/ml
—
6
55
29
243
1.25
0.42
1.7
1.8
1.7
1.3
mg/l
0.30
22
191
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
3.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
9
67
1.37
0.39
2.3
1.7
—
—
—
0
0
13
167
0.76
0.37
5.4
4.3
1.2
1.0
mmol/l
1.38
13
150
111
1069
1.21
0.32
18.9
15.6
23.0
25.3
mg/l
0.35
92
880
45
412
1.14
0.25
4.0
5.4
13.0
2.3
ug/l
0.50
36
354
53
492
1.13
0.24
4.5
4.0
—
—
—
0
0
5
38
1.33
0.23
1.6
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
5
39
1.29
0.23
2.2
2.5
0.2
0.3
u/ml
—
5
20
105
1017
1.14
0.22
4.7
4.6
1.4
1.5
mmol/l
0.99
95
905
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
6.3
—
0
6
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
201.0
—
0
13
6
77
0.77
0.16
1.0
1.9
—
—
—
0
0
88
852
1.09
0.15
6.6
7.1
72.1
79.6
u/l
1.62
82
791
12
103
1.18
0.14
3.5
3.6
85.8
91.4
ng/l
0.12
12
90
12
135
0.88
0.10
8.0
9.3
—
—
—
0
0
5
46
1.09
0.09
1.6
2.1
—
—
—
0
0
48
500
0.94
0.09
6.4
4.0
34.8
35.0
g/l
0.12
42
469
6
70
0.85
0.08
1.0
1.7
—
—
—
0
0
31
320
0.96
0.03
4.6
4.8
24.6
20.5
%
0.47
13
158
13
126
1.04
0.00
1.2
1.5
—
—
—
0
0
99
992
0.99
0.00
3.7
4.1
1.3
1.3
mmol/l
0.13
89
878
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
23.8
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
4.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
11.8
—
0
7
6
62
0.97
0.00
1.2
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
106.2
—
0
5
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
237.9
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_POSTMASTNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTMASTNAS | 1.322 [1.09, 1.61] | 0.006 |
| Birth year | 0.994 [0.99, 1.0] | 0.194 |
During the follow-up period (1.1.1998 — 31.12.2019), 152 out of 602 females with H8_POSTMASTNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTMASTNAS | 1.037 [0.84, 1.29] | 0.741 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 142 out of 605 males with H8_POSTMASTNAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_POSTMASTNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.151% | 0.198% |
| 5 | 0.789% | 1.264% |
| 10 | 1.944% | 2.977% |
| 15 | 3.714% | 5.379% |
| 20 | 6.312% | 9.286% |
Relationships between endpoints
↥Index endpoint: H8_POSTMASTNAS – Other disorders following mastoidectomy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data