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Other disorders following mastoidectomy

DOID EFO Endpoint Browser PheWeb

H8_POSTMASTNAS

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H95.1
  • Cause of death: ICD-10 — H95.1

2 out of 7 registries used, show all original rules.

138

4. Check minimum number of events

None

138

5. Include endpoints

None

138

6. Filter based on genotype QC (FinnGen only)

128

Control definitions (FinnGen only)

Control exclude
H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H95
Name in latin
Aliae morbositates post operationem auris mediae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1322 658 658
Only index persons 1256 626 630
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 65.04 68.12 61.92
Only index persons 64.61 67.69 61.56

-FinnGen-

Key figures

All Female Male
Number of individuals 128 60 68
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 62.18 60.90 63.30

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
138
Matched controls
1380
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
199.4
138
*
UDC00
NOMESCO Finland
Ear microscopy
128.1
177.0
103
31
H71
ICD-10 Finland
Cholesteatoma of middle ear
1593.2
86.4
75
*
DFF00
NOMESCO Finland
Pure tone audiometry
32.2
74.3
54
27
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
88.6
47.4
51
9
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
41.8
38
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
12.8
41.0
48
55
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
28.1
26
*
DAX08
NOMESCO Finland
Fitting of hearing aid
72.7
26.2
29
5
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
+∞
25.8
24
*
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
24.7
23
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
31.5
24.4
32
13
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
95.6
22.5
24
*
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
+∞
21.4
20
*
WX704
NOMESCO Finland
Intubation
8.5
19.9
29
42
Z97.4
ICD-10 Finland
Presence of external hearing-aid
45.5
19.2
23
6
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
51.9
18.9
22
5
H66.0
ICD-10 Finland
Acute suppurative otitis media
8.1
18.1
27
40
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
18.1
17
*
DFF15
NOMESCO Finland
Speech audiometry
34.1
18.1
23
8
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
17.0
16
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
17.0
16
*
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
17.0
16
*
Z01.8
ICD-10 Finland
Other specified special examinations
4.7
16.7
54
166
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
54.6
16.5
19
*
S02CA02
ATC
flumetasone and antiinfectives; otic
7.6
16.0
25
39
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
15.9
15
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
24.5
15.2
21
10
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
64.1
15.2
17
*
TDA90
NOMESCO Finland
Removal wax from ear
48.1
14.5
17
*
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
154.6
13.7
14
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
77.2
12.8
14
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
77.2
12.8
14
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
12.7
12
*
DCD00
NOMESCO Finland
Myringoplasty
+∞
12.7
12
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
10.3
12.7
25
29
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
16.7
12.2
19
13
WX720
NOMESCO Finland
Own respiration
11.7
12.0
22
22
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
11.6
11
*
Z97.8
ICD-10 Finland
Presence of other specified devices
130.4
11.6
12
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.2
11.6
27
62
Z98.8
ICD-10 Finland
Other specified postsurgical states
22.4
11.4
16
8
H93.1
ICD-10 Finland
Tinnitus
27.8
11.4
15
6
H66.9
ICD-10 Finland
Otitis media, unspecified
9.6
11.4
23
28
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
10.5
10
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
4.4
10.1
29
79
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
59.3
9.8
11
*
4151
FHL
Reoperation for chronic otitis media
+∞
9.5
9
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
12.7
9.3
16
14
WX725
NOMESCO Finland
Noninvasive ventilation
7.8
9.3
21
31
-31
ICPC
Medical examin/health eval partial
5.1
9.2
21
47
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
29.6
8.6
11
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.0
8.2
19
43
H65.2
ICD-10 Finland
Chronic serous otitis media
26.7
7.7
10
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
26.7
7.7
10
*
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
84.4
7.5
8
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
10.2
7.5
14
15
J01DA09
ATC
[U] cefadroxil
2.8
7.4
49
224
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
7.4
7
*
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
+∞
7.4
7
*
DC1AD
NOMESCO Finland
Temporalbone CT
31.8
7.2
9
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.1
7.0
34
131
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.7
6.9
50
239
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
23.9
6.8
9
*
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
73.1
6.5
7
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
73.1
6.5
7
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
73.1
6.5
7
*
H95.9
ICD-10 Finland
Postprocedural disorder of ear and mastoid process, unspecified
+∞
6.3
6
*
-34
ICPC
Blood test
10.7
6.2
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
40
121
4.25
12.25
1.9
1.8
—
—
—
0
0
22
60
4.17
7.54
6.6
7.3
—
—
—
0
0
32
128
2.95
6.08
1.6
1.4
—
—
—
0
0
25
91
3.13
5.56
4.8
3.2
—
—
—
0
0
8
8
10.52
4.58
2.0
2.5
—
—
—
0
0
9
275
0.28
4.51
2.4
4.0
97.00
85.29
%
—
9
269
54
348
1.91
3.22
3.3
3.1
7.21
7.51
mmol/l
0.19
46
297
12
295
0.35
3.21
3.4
6.5
—
—
—
0
0
53
341
1.90
3.17
3.4
3.2
22.26
98.73
mg/l
2.24
24
240
55
364
1.85
2.98
3.7
3.8
3.33
16.11
mg/mmol
2.41
27
240
17
328
0.45
2.50
4.2
3.1
—
—
—
0
0
27
149
2.01
2.47
5.7
5.9
3.34
1.30
mmol/l
1.61
18
116
0
59
0.00
2.31
0.0
3.3
—
0.72
—
0
59
64
470
1.67
2.29
2.1
2.1
91.07
91.26
pmol/l
0.01
38
239
27
427
0.54
2.14
4.0
3.7
15.21
97.43
e6/l
2.26
16
311
92
753
1.67
2.08
5.8
4.3
—
—
—
0
0
0
47
0.00
1.74
0.0
3.6
—
—
—
0
0
123
1114
1.96
1.68
21.5
14.8
—
—
—
0
0
16
87
1.95
1.53
1.4
1.5
—
—
—
0
0
21
328
0.58
1.52
2.1
3.4
—
—
—
0
0
116
1043
1.70
1.48
5.4
4.8
5.88
6.06
mmol/l
1.08
107
934
87
737
1.49
1.42
5.4
4.6
—
654.00
—
0
16
8
157
0.48
1.35
3.4
6.4
104.75
104.27
mmol/l
—
8
157
0
40
0.00
1.35
0.0
6.1
—
—
—
0
0
24
352
0.61
1.34
1.8
2.4
—
—
—
0
0
111
999
1.57
1.27
4.7
4.7
2.06
1.98
mu/l
0.30
99
880
10
50
2.08
1.20
2.0
3.8
—
—
—
0
0
64
525
1.41
1.17
5.1
5.4
1.21
1.21
mmol/l
0.02
59
482
5
20
2.55
1.16
1.2
1.1
—
—
—
0
0
111
1007
1.52
1.14
6.3
6.2
39.45
40.76
mmol/mol
1.03
101
926
70
586
1.39
1.12
10.6
16.2
1.61
1.32
inr
0.42
13
175
24
165
1.55
1.06
1.8
1.7
—
—
—
0
0
29
386
0.69
1.00
2.2
3.1
2.32
2.35
mmol/l
0.63
24
342
90
795
1.38
0.99
3.3
3.8
15.02
14.89
pmol/l
0.22
81
694
0
30
0.00
0.98
0.0
4.9
—
37.44
—
0
18
90
797
1.37
0.97
5.3
4.1
13.44
13.93
mm/h
0.11
82
722
12
71
1.76
0.92
1.4
1.2
—
—
—
0
0
13
202
0.61
0.91
1.3
1.5
2.79
2.66
g/l
—
7
118
125
1180
1.63
0.88
25.0
23.4
39.98
39.68
%
0.15
89
1108
46
372
1.35
0.87
3.5
3.5
—
—
—
0
0
16
105
1.59
0.86
3.4
3.7
—
—
—
0
0
43
345
1.36
0.86
3.4
4.3
—
—
—
0
0
112
1039
1.41
0.82
4.6
4.7
4.46
4.50
mmol/l
0.19
102
943
19
264
0.67
0.81
1.2
1.4
—
—
—
0
0
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
0
24
0.00
0.80
0.0
2.9
—
—
—
0
0
0
24
0.00
0.80
0.0
2.9
—
4.05
—
0
24
0
24
0.00
0.80
0.0
1.3
—
—
—
0
0
0
24
0.00
0.80
0.0
2.9
—
106.79
—
0
24
10
160
0.60
0.79
1.7
1.6
—
—
—
0
0
0
27
0.00
0.78
0.0
1.2
—
—
—
0
0
6
107
0.54
0.76
1.3
1.4
—
—
—
0
0
77
681
1.30
0.76
5.1
4.5
6.95
6.73
mmol/l
0.41
70
645
7
118
0.57
0.71
1.6
1.4
—
—
—
0
0
7
119
0.57
0.71
1.7
4.5
5.56
5.78
kpa
—
7
112
32
253
1.34
0.70
1.4
1.9
373.74
416.42
pmol/l
0.69
27
215
114
1071
1.37
0.67
5.5
5.3
2.57
2.61
mmol/l
0.20
103
960
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
0
20
0.00
0.61
0.0
4.3
—
58.25
—
0
20
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
120
1142
1.39
0.59
10.5
10.7
24.05
24.63
u/l
0.18
111
1100
29
232
1.32
0.59
4.0
4.3
1.02
1.02
kg/l
—
10
33
0
23
0.00
0.59
0.0
4.0
—
—
—
0
0
0
23
0.00
0.59
0.0
1.9
—
—
—
0
0
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
8
54
1.51
0.58
2.4
2.3
—
—
—
0
0
9
61
1.51
0.55
1.0
1.4
—
—
—
0
0
6
39
1.56
0.53
1.0
1.3
—
—
—
0
0
24
298
0.76
0.53
2.5
3.7
—
—
—
0
0
12
166
0.70
0.51
1.3
1.2
12.83
44.89
iu/ml
—
6
56
11
154
0.69
0.50
1.5
1.2
—
14.41
—
0
59
29
238
1.28
0.49
1.4
1.8
803.73
1188.74
nmol/l
2.76
22
184
30
248
1.27
0.48
1.6
1.7
1.65
1.38
mg/l
0.23
23
195
8
120
0.65
0.48
1.6
4.4
—
—
—
0
0
9
130
0.67
0.45
1.8
1.4
—
—
—
0
0
19
238
0.77
0.45
3.7
4.0
—
—
—
0
0
6
94
0.62
0.44
3.3
4.0
—
—
—
0
0
54
483
1.19
0.42
2.9
4.4
26.68
53.10
ng/l
1.58
32
379
0
15
0.00
0.41
0.0
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
4.5
—
68.93
—
0
15
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
3.4
—
4.46
—
0
19
113
1083
1.24
0.39
19.0
15.8
23.20
25.67
mg/l
0.40
94
888
44
492
0.84
0.37
5.9
6.3
—
—
—
0
0
11
82
1.37
0.35
2.2
3.5
—
7.40
—
0
12
107
1030
1.17
0.29
4.7
4.6
1.39
1.46
mmol/l
1.23
97
921
47
429
1.14
0.27
3.9
5.4
12.50
2.27
ug/l
0.51
38
367
90
858
1.14
0.27
6.7
7.3
72.32
80.29
u/l
1.79
84
801
10
126
0.78
0.25
1.5
1.3
—
—
—
0
0
6
81
0.73
0.25
1.8
2.6
10.00
9.94
g/l
—
6
73
6
81
0.73
0.25
2.8
2.4
—
—
—
0
0
11
88
1.27
0.23
1.5
1.4
—
—
—
0
0
5
40
1.26
0.22
3.2
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
5.31
—
0
10
0
12
0.00
0.21
0.0
2.1
—
32.43
—
0
12
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.9
—
477.57
—
0
7
14
165
0.83
0.21
5.1
4.4
1.16
1.05
mmol/l
1.57
14
148
9
115
0.77
0.21
1.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
19
166
1.17
0.19
2.6
2.4
28.18
21.88
%
—
5
148
40
431
0.90
0.18
2.5
2.2
—
—
—
0
0
5
67
0.74
0.17
1.0
1.6
0.75
1.50
g/l
—
5
61
12
102
1.19
0.15
3.5
3.6
85.83
91.43
ng/l
0.12
12
90
8
97
0.81
0.14
1.3
2.1
0.21
0.21
g/l
—
8
88
5
63
0.79
0.08
2.0
1.5
—
—
—
0
0
49
508
0.95
0.08
6.3
4.1
34.57
34.96
g/l
0.21
43
481
10
89
1.13
0.07
1.9
1.5
—
—
—
0
0
16
149
1.08
0.05
1.2
1.3
—
—
—
0
0
34
347
0.97
0.01
4.4
4.4
—
—
—
0
0
101
1003
1.03
0.01
3.7
4.1
1.28
1.25
mmol/l
0.26
91
892
77
769
1.00
0.00
4.9
4.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
275.00
—
0
6
0
6
0.00
-0.00
0.0
2.8
—
2365.83
—
0
6
6
60
1.00
-0.00
1.5
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
206.11
—
0
7
0
8
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
1751.67
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.5
—
50.17
—
0
6
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
13.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
12.05
—
0
6
0
5
0.00
-0.00
0.0
2.2
—
1.19
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
10.57
—
0
8
0
5
0.00
-0.00
0.0
5.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
27.00
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H8_POSTMASTNAS and mortality.

Females

Parameter HR [95% CI] p-value
H8_POSTMASTNAS 1.322 [1.09, 1.61] 0.006
Birth year 0.994 [0.99, 1.0] 0.194

During the follow-up period (1.1.1998 — 31.12.2019), 152 out of 602 females with H8_POSTMASTNAS died.

Males

Parameter HR [95% CI] p-value
H8_POSTMASTNAS 1.037 [0.84, 1.29] 0.741
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 142 out of 605 males with H8_POSTMASTNAS died.

Mortality risk

Mortality risk for people of age

years, who have H8_POSTMASTNAS.

N-year risk Females Males
1 0.151% 0.198%
5 0.789% 1.264%
10 1.944% 2.977%
15 3.714% 5.379%
20 6.312% 9.286%

Relationships between endpoints

↥

Index endpoint: H8_POSTMASTNAS – Other disorders following mastoidectomy

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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