Cerebral arteritis

I9_CEREBRART

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I67.7, I68.1, I68.1A18.8, I68.1A32.8, I68.1A52.0, I68.1B02.8, I68.2, I68.2M32.1 Hospital discharge:* ICD-9 — 4374 Cause of death: ICD-10 — I67.7, I68.1, I68.1A18.8, I68.1A32.8, I68.1A52.0, I68.1B02.8, I68.2, I68.2M32.1 Cause of death:* ICD-9 — 4374 2 out of 7 registries used, show all original rules.	95
4. Check minimum number of events None	95
5. Include endpoints None	95
6. Filter based on genotype QC (FinnGen only)	95

Control definitions (FinnGen only)

Control exclude: I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	I9_CEREBRART
CONTROL_EXCLUDE	I9_CEREBVASC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I677\|I68[1-2]
HD_ICD_9	4374
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I677\|I68[1-2]
COD_ICD_9	4374
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Cerebral arteritis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	614	387	221
Only index persons	486	311	175
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	53.20	52.39	54.98
Only index persons	49.65	48.58	51.56

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	95	62	33
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	48.94	48.69	49.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
86: Matched controls
861

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I67.7

ICD-10 Finland

Cerebral arteritis, not elsewhere classified

+∞

81.7

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

+∞

34.7

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

346.3

26.2

L04AX01

ATC

azathioprine; systemic

34.5

23.3

TAB00

NOMESCO Finland

Lumbar puncture

32.1

17.0

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

15.0

16.9

XA800

NOMESCO Finland

Neuropsychological investigation

23.6

16.3

R51.80

ICD-10 Finland

Headache

8.4

14.0

AA1AD

NOMESCO Finland

CT of head and brain

7.0

13.5

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

24.8

13.1

H02AB06

ATC

prednisolone; systemic

5.5

12.2

274

R4150

NOMESCO Finland

Neuropsychological rehabilitation

+∞

11.7

B01AC04

ATC

clopidogrel; oral

7.7

11.0

I67.6

ICD-10 Finland

Nonpyogenic thrombosis of intracranial venous system

+∞

10.6

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

+∞

10.6

M32.9

ICD-10 Finland

Systemic lupus erythematosus, unspecified

45.7

10.3

R4120

NOMESCO Finland

Occupational therapy

11.6

9.8

I67.1

ICD-10 Finland

Cerebral aneurysm, nonruptured

+∞

9.5

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

22.9

8.7

PA2BD

NOMESCO Finland

Extensive CT angiography of brain

99.3

8.6

TPH04

NOMESCO Finland

Cathetrisation of vein

5.0

8.5

I63.8

ICD-10 Finland

Other cerebral infarction

+∞

8.5

M32.1

ICD-10 Finland

Systemic lupus erythematosus with organ or system involvement

+∞

8.5

PA2CC

NOMESCO Finland

Cerebral very extensive angiography with X-ray

+∞

8.5

B01AA03

ATC

warfarin; systemic

5.4

8.4

H02AB07

ATC

prednisone; oral

5.3

8.0

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

7.3

7.9

PA6BD

NOMESCO Finland

Extensive CT of neck arteries

20.7

7.8

Z01.0

ICD-10 Finland

Examination of eyes and vision

5.2

7.5

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

9.3

7.5

M32.0

ICD-10 Finland

Drug-induced systemic lupus erythematosus

+∞

7.4

I68.2*M32.1

ICD-10 Finland

Cerebral arteritis in systemic lupus erythematosus

+∞

7.4

L04AA06

ATC

mycophenolic acid; systemic

33.0

7.3

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.6

7.0

172

AA1DM

NOMESCO Finland

Very extensive MRI examination of brain with 3 Tesla magnet

29.0

6.3

R4130

NOMESCO Finland

Speech therapy

29.0

6.3

XCK00

NOMESCO Finland

Perimetry

7.7

6.3

PA6AG

NOMESCO Finland

Limited MRI examination of neck vasculature with high intensity magnet

+∞

6.3

M32.8

ICD-10 Finland

Other forms of systemic lupus erythematosus

+∞

6.3

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

4.5

6.1

G45.1

ICD-10 Finland

Carotid artery syndrome (hemispheric)

16.5

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3044290) Cell count panel - Cerebral spinal fluid

38.96

15.50

2.3

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

9.65

14.57

4.9

2.7

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

11.56

12.54

1.4

1.0

u/ml

19.0

3.8

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

+∞

11.69

1.3

0.0

—

(4027681)

23.11

10.15

1.9

1.0

—

(3013247) Albumin in CSF/Albumin in Serum or Plasma

+∞

9.53

2.0

0.0

mg/g

10.2

—

(3037522) Nuclear Ab [Titer] in Serum

113

3.94

8.62

1.8

1.4

titre

509.1

590.0

0.15

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

+∞

8.45

2.1

0.0

—

(4268621)

10.04

8.23

2.4

1.6

—

(3032080) INR in Blood by Coagulation assay

270

3.18

7.15

10.5

9.2

inr

1.2

0.14

(3004588) Protein electrophoresis panel - Serum or Plasma

4.70

6.99

1.6

2.6

—

(3003396) Base excess in Arterial blood by calculation

4.10

6.92

5.0

6.6

mmol/l

-0.5

2.3

3.95

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.87

6.70

1.8

3.6

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

19.64

6.39

1.6

1.0

—

(3023368) Bacteria identified in Blood by Culture

167

2.99

5.96

3.8

4.2

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

5.79

5.67

1.6

3.0

183.1

182.8

0.00

(3023365) Varicella zoster virus Ab [Titer] in Cerebral spinal fluid

+∞

5.25

1.2

0.0

—

(3012320) Pathologist interpretation of Cerebral spinal fluid tests

+∞

5.25

2.0

0.0

—

(3006441) Cardiolipin IgM Ab [Presence] in Serum by Immunoassay

+∞

5.25

1.4

0.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

14.38

5.18

1.4

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

12.45

4.35

1.4

1.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.60

4.27

1.8

1.6

—

(3014007) Fractional oxyhemoglobin in Arterial blood

4.15

4.23

3.8

6.3

95.4

93.1

0.76

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

10.66

4.08

1.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

10.66

4.08

1.0

1.3

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

10.66

4.08

1.0

1.3

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

4.02

4.07

3.8

5.9

0.6

0.8

0.63

(3006315) Basophils [#/volume] in Blood

372

2.33

3.89

11.7

5.9

e9/l

0.0

0.09

331

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

9.32

3.84

1.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

9.32

3.84

1.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

9.32

3.84

1.0

1.3

—

(3001604) Monocytes [#/volume] in Blood

374

2.31

3.81

11.7

5.8

e9/l

0.6

0.64

330

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

260

2.29

3.77

5.8

2.8

—

(3019198) Lymphocytes [#/volume] in Blood

385

2.30

3.75

11.6

5.8

e9/l

1.9

1.8

0.38

343

(46235355) HIV 1 and 2 tests - Meaningful Use set

124

2.51

3.57

1.4

2.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

336

2.21

3.52

4.7

4.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

480

2.34

3.52

5.7

4.4

e6/l

85.0

5861.3

—

(42870588) Differential panel, method unspecified - Blood

252

2.19

3.39

13.7

5.6

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

172

2.30

3.36

2.9

1.9

mg/l

2.6

3.2

0.98

156

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

5.11

3.33

1.3

1.6

—

(3000991) Gas panel - Venous blood

3.19

3.17

3.7

5.6

—

(4306422)

6.20

3.08

1.0

1.1

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

6.20

3.08

1.0

131.6

112.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

112

2.39

2.99

1.3

1.6

—

(3002582) Erythrocytes [#/volume] in Urine

230

2.09

2.92

4.5

2.9

e6/l

24.9

27.4

0.07

178

(3018418) pH of Serum or Plasma

230

2.09

2.92

3.7

3.4

7.4

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

8.70

2.78

5.4

5.7

mg/l

12.6

13.8

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

116

2.30

2.75

3.9

2.4

e6/l

1.5

0.7

0.36

(3013650) Neutrophils [#/volume] in Blood by Automated count

447

2.02

2.69

13.9

9.9

e9/l

4.4

3.8

1.65

398

(3019060) Gas panel - Arterial blood

2.98

2.66

5.6

3.9

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.71

2.55

6.8

8.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.51

1.6

1.5

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

3.17

2.49

4.2

5.0

1.3

1.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.38

2.48

1.9

1.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.08

2.38

3.1

4.2

mmol/l

24.6

24.9

—

(3005322) IgE [Units/volume] in Serum or Plasma

2.78

2.37

1.1

1.2

u/ml

246.2

135.2

0.33

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

4.85

2.31

1.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

103

2.19

2.26

1.6

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

105

2.15

2.16

4.2

2.7

e6/l

2.7

2.0

0.28

(40758558) Short blood count panel - Blood

184

1.92

2.13

8.3

7.1

—

(3023520) Reticulocytes [#/volume] in Blood

2.60

2.12

1.8

3.6

e9/l

66.6

73.3

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

5.21

2.09

1.4

—

(3018095) Leukocytes [#/volume] in Urine

272

1.81

2.05

6.3

3.3

e6/l

23.9

68.3

0.60

198

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.51

2.00

2.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.25

1.93

1.7

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

157

1.90

1.92

1.8

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.69

1.87

1.3

1.4

—

(3026008) Bacteria identified in Urine by Culture

226

1.79

1.85

3.1

3.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

168

1.85

1.81

1.6

1.5

g/l

2.4

2.7

0.24

101

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.31

1.81

1.4

2.5

u/l

31.5

31.4

0.01

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.65

1.79

1.0

1.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.46

1.78

1.0

1.7

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

337

1.71

1.77

3.5

2.5

ug/l

101.6

100.5

0.02

307

(36304419) Bacteria [Presence] in Urine

203

1.78

1.76

4.5

2.5

—

(3000494) Fungus identified in Specimen by Culture

2.06

1.74

1.5

1.4

—

(40761535) Cells panel - Urine sediment

2.31

1.69

4.9

3.8

—

(3015736) pH of Urine

303

1.69

5.2

3.4

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.30

1.69

1.2

1.4

—

(3052851) Hemolysis interference index of Serum or Plasma

3.30

1.69

2.0

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

148

1.83

1.65

6.3

3.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.63

1.64

1.5

1.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.71

1.63

1.0

1.2

—

(3037756) Immunofixation for Serum or Plasma

3.71

1.63

1.6

—

(3044640) Blood type and Crossmatch panel - Blood

225

1.72

1.62

1.7

1.9

—

(3030467) Casts [#/volume] in Urine by Automated count

208

1.73

1.61

4.5

2.7

e6/l

0.1

0.2

0.71

156

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

2.22

1.57

3.2

2.7

ug/l

3.7

4.0

0.08

(3003327) Ova and parasites identified in Stool by Light microscopy

2.72

1.54

1.9

1.4

—

(40768797) Stomach Pathology biopsy report

103

1.92

1.54

1.4

1.2

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

2.98

1.53

1.7

3.0

g/l

3.7

3.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.98

1.53

1.0

1.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.18

1.51

1.3

1.8

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

130

1.79

1.42

4.1

3.0

ng/l

8.7

38.9

1.37

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.04

1.37

1.2

1.3

—

(1761868) Lipid panel - Serum or Plasma

311

0.58

1.35

3.0

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

281

1.59

1.33

1.9

pmol/l

101.9

99.0

0.23

132

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

2.87

1.30

1.2

1.7

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.72

1.23

1.2

1.7

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.72

1.23

1.8

1.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

785

2.01

1.23

21.7

12.7

mg/l

19.7

19.9

0.02

603

(3037467) Urinalysis macro (dipstick) panel - Urine

511

1.54

1.18

7.7

4.3

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.04

1.12

2.9

2.1

ng/l

71.4

95.9

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.45

1.10

1.2

1.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

391

1.46

1.01

7.2

5.1

estimate

0.0

—

(3022145) Colonoscopy Study observation

1.67

0.91

1.2

1.3

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

113

1.61

0.90

1.6

2.8

mmol/l

0.8

0.72

108

(3035350) Ketones [Presence] in Urine by Test strip

390

1.41

0.86

5.4

3.7

estimate

0.0

—

(3019309) Folate [Moles/volume] in Red Blood Cells

124

1.56

0.83

1.5

1.7

nmol/l

1237.3

1293.6

0.08

(3009261) Glucose [Presence] in Urine by Test strip

393

1.39

0.81

5.7

3.7

estimate

0.0

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.80

0.0

4.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.66

0.80

1.2

1.8

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.05

0.74

1.4

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

777

0.70

0.71

5.9

4.2

mmol/l

1.3

1.5

1.83

715

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.72

0.70

1.0

1.2

—

(3018405) Lactate [Moles/volume] in Arterial blood

1.90

0.69

4.0

4.8

mmol/l

1.2

—

(3025941) Bacteria identified in Stool by Culture

1.64

0.66

1.0

1.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

177

1.40

0.62

1.2

1.3

u/ml

0.7

1.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.60

0.62

2.0

—

(36660697) Celiac disease serology panel - Serum

1.53

0.59

1.1

1.2

—

(1002224) Polysomnography panel

1.71

0.58

1.0

1.1

—

(3012544) pH of Venous blood

1.52

0.56

2.6

3.5

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

806

1.52

0.54

24.1

13.9

mmol/l

139.3

139.7

0.76

780

(3023103) Potassium [Moles/volume] in Serum or Plasma

807

1.51

0.52

24.4

14.0

mmol/l

4.0

0.04

780

(3029937) Albumin [Presence] in Urine by Test strip

212

1.31

0.49

5.8

4.0

estimate

0.0

—

(3021589) Normoblasts [#/volume] in Blood

356

1.27

0.48

16.1

10.2

e9/l

0.0

0.00

291

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

300

1.26

0.45

4.8

3.8

ng/l

59.2

37.5

0.23

198

(3003694) ABO and Rh group [Type] in Blood

205

1.30

0.45

1.2

1.4

—

(3002256) Pathology report gross observation

0.64

0.45

1.2

—

(3020891) Body temperature

1.65

0.44

4.6

2.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

322

1.24

0.42

5.1

3.9

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.5

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

161

1.31

0.41

1.5

1.2

iu/ml

14.4

38.5

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

2.8

—

60.5

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.41

0.0

2.4

—

7.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.39

0.0

1.4

—

(3003338) MCHC [Mass/volume]

687

1.27

0.39

31.3

15.3

g/l

330.7

332.3

0.86

681

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

754

0.81

0.31

17.9

11.8

ml/min/173m2

87.8

83.0

0.77

616

(3020564) Creatinine [Moles/volume] in Serum or Plasma

840

1.42

0.31

26.2

14.5

umol/l

78.2

75.7

0.30

840

(40761511) CBC panel - Blood by Automated count

833

1.34

0.29

21.3

12.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

743

0.82

0.29

24.9

12.0

38.0

40.4

0.94

562

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.27

0.28

1.6

2.5

g/l

0.3

0.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

790

0.81

0.28

6.2

4.8

mmol/l

2.4

2.8

4.78

724

(3013512) EKG study

233

0.82

0.28

3.0

3.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

135

0.79

0.23

1.2

1.4

—

(3009508) Creatinine [Moles/volume] in Urine

212

1.18

0.22

4.7

2.9

mmol/l

7.7

8.3

0.19

183

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.20

0.22

3.6

3.4

pmol/l

4.1

4.7

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.1

—

(3024928) Oxygen saturation in Venous blood

0.00

0.21

0.0

3.5

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.3

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

2.3

—

4.0

—

(4281824)

0.00

0.21

0.0

1.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

2.3

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

2.3

—

105.3

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

2.2

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.5

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.20

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.20

0.0

1.6

—

(3044889) 12 lead EKG panel

551

1.14

0.19

4.0

3.6

—

(3019225) pH of Specimen

1.22

0.18

6.7

4.3

—

(3035941) MCH [Entitic mass]

880

0.87

0.17

34.3

18.6

30.0

30.3

0.83

865

(3024731) MCV [Entitic volume]

880

0.87

0.17

34.4

18.6

90.5

91.1

0.71

865

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.14

0.15

16.6

7.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.77

0.15

2.1

1.9

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

190

0.87

0.14

4.2

4.5

ug/l

2.1

1.7

0.25

173

(3041096) Erythrocytes [Presence] in Urine by Automated

250

0.89

0.13

4.1

3.5

—

(3012516) Albumin [Mass/volume] in Urine

201

1.12

0.13

5.1

3.0

mg/l

3476.0

370.4

0.45

135

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

520

0.92

0.11

2.9

3.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

193

1.11

0.11

6.4

5.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.12

0.10

1.4

2.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

215

1.09

0.08

5.2

3.9

mg/mmol

39.9

5.8

0.78

139

(3000492) Spirometry study

0.80

0.08

1.2

1.4

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

554

1.07

0.08

3.8

3.0

u/l

55.0

48.6

0.23

526

(40761536) Microorganisms panel - Urine sediment

0.85

0.08

3.3

3.5

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.06

0.07

1.4

4.0

mmol/l

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.09

0.07

5.2

3.7

—

(3042936) Bacteria identified in Isolate by Culture

109

1.12

0.06

3.3

1.7

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

782

0.92

0.06

5.7

4.3

mmol/l

4.3

4.7

4.28

722

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

149

0.93

0.03

4.1

4.2

22.4

22.0

—

(40768804) Tissue Pathology biopsy report

311

1.04

0.03

1.7

2.0

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

843

1.08

0.02

17.7

9.9

u/l

29.2

26.0

1.06

814

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

152

0.98

0.00

1.3

1.2

u/ml

1.0

8.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

163

0.98

0.00

1.3

1.5

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(4146454)

0.00

0.0

3.8

—

(3011648) Oxygen content in Venous blood

0.00

0.0

3.4

—

12.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(3004451) EKG impression Narrative

0.00

0.0

1.4

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.3

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

1.4

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.3

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

14.2

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.0

—

11.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.0

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

10.9

—

0.7

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

4.2

—

63.6

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

12.5

—

867.4

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

(21494755) Public health laboratory ask at order entry panel

0.96

0.00

1.8

1.4

—

(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma

0.00

0.0

2.7

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.2

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.9

—

17.0

—

(4010399)

0.97

0.00

1.2

1.3

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(4035726)

0.92

0.00

1.2

1.3

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.0

—

13.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.93

0.00

1.6

2.1

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.6

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

(3012565) Volume of 24 hour Urine

0.00

0.0

1.7

—

2074.2

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.0

1.6

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

17.0

—

1521.5

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.3

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.5

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

3.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint I9_CEREBRART and mortality.

Females

Parameter	HR [95% CI]	p-value
I9_CEREBRART	2.464 [1.74, 3.48]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.153

During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 288 females with I9_CEREBRART died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have I9_CEREBRART.

N-year risk	Females	Males
1	0.188%	No data
5	1.119%	No data
10	3.367%	No data
15	6.757%	No data
20	11.596%	No data

Relationships between endpoints

↥

Index endpoint: I9_CEREBRART – Cerebral arteritis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Cerebral arteritis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints