Airway disease due to specific organic dust

J10_AIRWDISDUST

byssinosis: An occupational lung disorder caused by exposure to cotton dust. It occurs more commonly in workers in the textile industry. Signs and symptoms include chest tightness, cough and wheezing. The symptoms tend to get worse at the beginning of the week and subside by the end of the week.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J66 Hospital discharge: ICD-9 — 504 Cause of death: ICD-10 — J66 Cause of death: ICD-9 — 504 2 out of 7 registries used, show all original rules.	94
4. Check minimum number of events None	94
5. Include endpoints None	94
6. Filter based on genotype QC (FinnGen only)	91

Control definitions (FinnGen only)

Control exclude: J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: J60-J70
Name in latin: Morbus viarum respiratoriarum e pulvere organico specifico

NAME	J10_AIRWDISDUST
CONTROL_EXCLUDE	J10_EXTERLUNG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J66
HD_ICD_9	504
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J66
COD_ICD_9	504
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Airway disease due to specific organic dust based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	675	305	364
Only index persons	584	272	312
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	45.30	44.90	45.45
Only index persons	44.00	44.43	43.61

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	91	49	42
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	45.20	40.60	50.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
94: Matched controls
940

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

J66.8

ICD-10 Finland

Airway disease due to other specific organic dusts

+∞

91.0

J45.0

ICD-10 Finland

Predominantly allergic asthma

9.8

21.9

J45.9

ICD-10 Finland

Asthma, unspecified

7.2

20.1

J66.0

ICD-10 Finland

Byssinosis

+∞

9.5

R03AC03

ATC

terbutaline; inhalant

4.9

9.4

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

4.2

9.3

108

J67.0

ICD-10 Finland

Farmer lung

+∞

8.5

H02AB06

ATC

prednisolone; systemic

3.6

8.3

310

XG410

NOMESCO Finland

Flow-volume spirometry

24.6

8.2

J45

ICD-10 Finland

Asthma

5.0

8.2

R03AC02

ATC

salbutamol; inhalant

3.8

8.1

393

J45.1

ICD-10 Finland

Nonallergic asthma

5.2

7.8

R03DC03

ATC

montelukast; oral

4.2

7.8

R06.0

ICD-10 Finland

Dyspnoea

3.3

7.2

159

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

13.6

6.8

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

4.2

6.1

XQ800

NOMESCO Finland

Prick test

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3005322) IgE [Units/volume] in Serum or Plasma

3.62

4.76

1.8

1.2

56.62

204.51

u/ml

1.28

(3013115) Eosinophils [#/volume] in Blood

388

2.63

4.76

9.1

5.8

0.21

0.19

e9/l

0.36

351

(3006315) Basophils [#/volume] in Blood

380

2.37

3.96

8.7

5.3

0.04

e9/l

0.37

342

(3001604) Monocytes [#/volume] in Blood

381

2.36

3.93

8.3

5.3

0.62

0.56

e9/l

1.16

341

(3019198) Lymphocytes [#/volume] in Blood

388

2.29

3.67

8.8

5.4

2.15

1.95

e9/l

0.55

354

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

4.75

2.86

2.4

2.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

358

1.93

2.49

8.9

6.0

—

(3000494) Fungus identified in Specimen by Culture

2.31

2.23

2.1

1.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

4.19

2.07

1.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

126

1.97

1.89

1.5

1.4

6.67

19.16

u/ml

0.89

(3023419) Bacteria identified in Sputum by Culture

4.00

1.74

6.8

1.8

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

132

1.87

1.64

1.5

1.3

12.97

25.87

iu/ml

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

3.13

1.61

3.2

2.0

10.43

9.01

mg/l

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.46

1.54

1.0

1.6

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.84

1.46

3.2

1.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.71

1.39

2.5

1.5

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

3.05

1.37

1.0

1.8

—

2.56

—

(3000492) Spirometry study

1.96

1.27

2.1

1.4

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.15

1.18

10.8

2.4

1.27

0.81

mmol/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.15

1.18

1.0

1.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.86

1.16

2.5

1.5

—

(3011288) Drugs identified in Urine by Screen method

2.58

1.16

1.4

1.1

—

(3022145) Colonoscopy Study observation

1.79

1.12

1.2

1.3

—

(1761868) Lipid panel - Serum or Plasma

341

0.64

1.10

2.8

2.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

108

1.70

1.05

2.6

1.8

—

(3019060) Gas panel - Arterial blood

1.97

1.04

3.3

4.8

—

(3022217) INR in Platelet poor plasma by Coagulation assay

342

1.47

1.03

16.3

11.3

1.18

1.11

inr

0.20

108

(3042936) Bacteria identified in Isolate by Culture

101

1.70

1.01

1.6

2.0

—

(4200892) Spirometry reversibility

1.95

1.01

1.3

—

(3022313) Gas panel - Capillary blood

2.30

0.95

13.8

2.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

505

1.45

0.93

6.3

3.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.89

0.88

2.1

1.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.81

0.85

1.4

1.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

141

1.53

0.83

3.9

4.1

159.85

167.38

ng/l

0.01

103

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.80

0.0

1.0

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

160

1.49

0.80

1.4

1.2

0.47

1.43

u/ml

—

(3010813) Leukocytes [#/volume] in Blood

887

0.56

0.78

27.4

18.5

6.88

6.66

e9/l

0.48

864

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.24

0.77

1.2

0.21

0.26

g/l

—

(3024731) MCV [Entitic volume]

886

0.58

0.77

27.2

18.4

91.23

90.82

0.35

874

(3026361) Erythrocytes [#/volume] in Blood

886

0.58

0.77

27.2

18.4

4.55

e12/l

0.01

862

(3000963) Hemoglobin [Mass/volume] in Blood

886

0.58

0.77

27.4

18.6

137.06

137.42

g/l

0.08

875

(40761511) CBC panel - Blood by Automated count

831

0.64

0.77

18.4

12.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

290

1.39

0.76

3.4

2.3

76.24

77.19

nmol/l

0.07

269

(3035941) MCH [Entitic mass]

885

0.59

0.76

27.1

18.4

30.29

30.35

0.11

873

(3007461) Platelets [#/volume] in Blood

885

0.59

0.76

27.5

18.5

254.73

250.94

e9/l

0.26

863

(3003694) ABO and Rh group [Type] in Blood

222

0.66

0.73

1.5

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.72

0.70

2.7

2.6

26.13

24.51

mmol/l

—

(3025941) Bacteria identified in Stool by Culture

1.68

0.68

1.1

1.2

—

(3018418) pH of Serum or Plasma

202

1.40

0.67

2.9

3.9

7.38

7.41

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.64

0.66

1.4

2.8

—

(3044640) Blood type and Crossmatch panel - Blood

213

1.38

0.64

2.4

2.1

—

(3023368) Bacteria identified in Blood by Culture

186

1.39

0.63

3.6

3.9

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.61

0.0

1.2

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

0.61

0.0

1.9

—

113.05

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.61

0.0

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

274

1.31

0.56

2.2

1.8

96.38

98.98

pmol/l

0.15

128

(3001019) Free T4 and TSH panel - Serum or Plasma

1.56

0.49

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

118

0.65

0.49

1.7

1.6

—

(3007164) IgA [Mass/volume] in Serum or Plasma

149

1.34

0.46

1.8

1.3

1.90

2.54

g/l

0.86

(40768804) Tissue Pathology biopsy report

291

1.26

0.45

1.9

1.8

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.62

0.45

1.3

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.61

0.44

4.0

7.0

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.65

0.44

4.2

4.4

25.28

24.29

mmol/l

—

(4035726) Immunohistochemistry procedure

1.39

0.42

1.1

1.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.54

0.42

2.4

1.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.41

0.0

1.4

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.41

0.0

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.50

0.41

2.8

1.5

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.40

0.0

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

512

1.23

0.40

3.0

3.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

805

0.76

0.38

4.4

4.9

2.75

2.80

mmol/l

0.20

755

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

574

1.24

0.38

4.5

3.9

14.96

14.82

pmol/l

0.16

532

(3002385) Erythrocyte distribution width [Ratio]

682

0.81

0.37

19.1

15.3

14.81

14.60

0.11

676

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.66

0.35

8.0

4.4

2.87

90.46

ug/l

—

(40758558) Short blood count panel - Blood

184

1.26

0.34

10.0

7.4

—

(3022948) Iron [Moles/volume] in Serum or Plasma

101

1.33

0.34

2.5

2.6

12.05

14.33

umol/l

0.55

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.37

0.34

1.7

325.55

353.27

nmol/l

0.18

(3011397) Hemoglobin [Presence] in Urine by Test strip

148

1.27

0.32

2.4

3.4

—

(40761535) Cells panel - Urine sediment

1.37

0.32

5.7

2.8

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

227

1.20

0.28

2.2

2.1

96.42

270.41

u/l

1.41

215

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

256

1.19

0.28

2.9

3.2

25.93

32.15

u/l

1.09

243

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

295

1.18

0.27

3.7

3.1

92.68

26.72

ng/l

0.54

199

(40768797) Stomach Pathology biopsy report

105

1.28

0.26

1.1

1.2

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

805

0.82

0.23

18.2

14.0

3.98

3.97

mmol/l

0.11

785

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

738

0.84

0.23

14.2

11.3

84.07

83.99

ml/min/173m2

0.01

604

(3013512) EKG study

228

0.84

0.22

4.5

3.1

—

(3021589) Normoblasts [#/volume] in Blood

349

1.15

0.22

9.8

9.5

0.00

e9/l

0.32

291

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.5

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.5

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.5

—

3.41

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.21

0.0

1.4

—

67.73

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.21

0.0

1.4

—

67.30

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.21

0.0

1.2

—

9.06

—

(3024928) Oxygen saturation in Venous blood

0.00

0.21

0.0

2.1

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.3

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.21

0.0

2.2

—

129.00

—

(3012516) Albumin [Mass/volume] in Urine

196

1.16

0.18

3.6

3.4

65.44

51.37

mg/l

0.10

132

(3019225) pH of Specimen

1.16

0.18

10.4

4.6

—

(3002256) Pathology report gross observation

1.25

0.18

1.3

1.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

203

0.86

0.17

4.1

4.0

16.67

21.60

—

(3035350) Ketones [Presence] in Urine by Test strip

364

1.12

0.17

3.8

3.2

0.00

estimate

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

800

0.85

0.16

18.2

13.9

140.09

139.69

mmol/l

1.04

781

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.14

0.15

2.7

1.8

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

722

0.88

0.15

5.9

5.3

41.53

39.55

mmol/mol

0.68

680

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.11

0.15

2.7

1.9

—

(21494755) Public health laboratory ask at order entry panel

0.80

0.14

1.3

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.79

0.14

1.6

1.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

367

1.11

0.14

5.6

4.3

0.00

estimate

—

(3026782) Osmolality of Urine

138

0.85

0.14

2.1

2.4

512.67

527.85

mosm/kgh2o

0.09

118

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

341

0.91

0.12

2.7

2.5

—

(3009261) Glucose [Presence] in Urine by Test strip

374

1.07

0.08

3.8

3.2

0.00

estimate

—

(3000850) Epithelial cells [#/volume] in Urine

147

1.11

0.08

2.8

2.2

3.41

3.65

e6/l

0.08

132

(3018095) Leukocytes [#/volume] in Urine

244

0.92

0.07

4.1

3.4

33.37

76.25

e6/l

0.45

177

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.03

0.07

2.2

2.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

798

1.11

0.07

18.5

12.0

22.46

22.13

mg/l

0.03

625

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

159

1.08

0.05

3.1

2.0

—

(36304419) Bacteria [Presence] in Urine

191

0.93

0.05

3.0

2.5

—

(3044889) 12 lead EKG panel

542

0.95

0.05

4.4

3.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

139

0.92

0.04

1.8

2.0

—

(3029937) Albumin [Presence] in Urine by Test strip

199

0.94

0.03

4.1

3.4

0.00

0.01

estimate

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

709

0.95

0.03

5.4

4.5

1.75

1.90

mu/l

0.58

657

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

261

1.05

0.03

4.6

4.4

4.61

1.98

ug/l

0.40

239

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

248

0.96

0.02

4.4

2.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

156

0.95

0.00

1.1

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

296

0.97

0.00

4.5

3.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

112

0.98

0.00

1.1

1.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

183

0.98

0.00

1.6

1.5

1.10

1.00

mg/l

0.09

152

(3009508) Creatinine [Moles/volume] in Urine

214

0.98

0.00

3.9

3.1

7.69

8.23

mmol/l

0.26

183

(3026008) Bacteria identified in Urine by Culture

196

1.03

0.00

3.1

2.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

209

1.01

0.00

5.2

3.9

8.62

8.00

mg/mmol

0.03

133

(3020564) Creatinine [Moles/volume] in Serum or Plasma

829

1.01

0.00

19.6

14.6

83.76

75.79

umol/l

0.74

829

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.99

0.00

1.8

2.1

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.2

—

49.33

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

-0.00

0.0

1.4

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.1

—

(36660697) Celiac disease serology panel - Serum

0.96

-0.00

1.4

1.2

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.3

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

2.4

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

9.67

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.1

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

2.8

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

-0.00

0.0

2.8

—

449.17

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

2.1

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

12.07

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.2

—

99.50

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

-0.00

0.0

2.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.98

-0.00

1.9

1.7

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.2

—

(3022192) Triglyceride [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.1

—

(3000012) Reticulocyte production index

0.00

-0.00

0.0

3.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

-0.00

0.0

2.0

—

32.33

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

0.96

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

7.8

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

230

1.00

-0.00

4.6

2.7

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3024263) Appearance of Synovial fluid

0.00

-0.00

0.0

1.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

1.7

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.3

—

(3015183) Erythrocyte sedimentation rate

0.00

-0.00

0.0

1.0

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.00

-0.00

1.5

1.2

—

32.90

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

0.93

-0.00

3.7

3.3

1.33

1.24

mmol/l

—

(3034426) Prothrombin time (PT)

0.00

-0.00

0.0

1.6

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.2

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

2.0

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

1.7

—

11.80

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

0.94

-0.00

4.0

4.1

106.25

104.74

mmol/l

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

2.3

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

1.49

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

174.14

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

1.5

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

4.9

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

5.8

—

142.09

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.1

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.1

—

176.14

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.2

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.5

—

(3022621) pH of Urine by Test strip

0.96

-0.00

3.0

2.2

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

-0.00

0.0

1.2

—

(40761536) Microorganisms panel - Urine sediment

0.86

-0.00

3.7

2.9

—

(3017704) Immunofixation for Urine

0.00

-0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

245.91

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.3

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint J10_AIRWDISDUST and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have J10_AIRWDISDUST.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: J10_AIRWDISDUST – Airway disease due to specific organic dust

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Airway disease due to specific organic dust

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints