Airway disease due to specific organic dust

J10_AIRWDISDUST

byssinosis: An occupational lung disorder caused by exposure to cotton dust. It occurs more commonly in workers in the textile industry. Signs and symptoms include chest tightness, cough and wheezing. The symptoms tend to get worse at the beginning of the week and subside by the end of the week.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J66 Hospital discharge: ICD-9 — 504 Cause of death: ICD-10 — J66 Cause of death: ICD-9 — 504 2 out of 7 registries used, show all original rules.	92
4. Check minimum number of events None	92
5. Include endpoints None	92
6. Filter based on genotype QC (FinnGen only)	92

Control definitions (FinnGen only)

Control exclude: J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: J60-J70
Name in latin: Morbus viarum respiratoriarum e pulvere organico specifico

NAME	J10_AIRWDISDUST
CONTROL_EXCLUDE	J10_EXTERLUNG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J66
HD_ICD_9	504
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J66
COD_ICD_9	504
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Airway disease due to specific organic dust based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	675	305	364
Only index persons	584	272	312
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	45.30	44.90	45.45
Only index persons	44.00	44.43	43.61

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	92	49	43
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	45.22	41.06	49.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
80: Matched controls
800

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

J66.8

ICD-10 Finland

Airway disease due to other specific organic dusts

+∞

78.6

J45.9

ICD-10 Finland

Asthma, unspecified

5.9

10.5

J45.0

ICD-10 Finland

Predominantly allergic asthma

8.8

10.4

J67.0

ICD-10 Finland

Farmer lung

+∞

8.5

J66.0

ICD-10 Finland

Byssinosis

+∞

7.4

R03AC02

ATC

salbutamol; inhalant

3.7

7.1

310

XG410

NOMESCO Finland

Flow-volume spirometry

14.0

6.3

J30.3

ICD-10 Finland

Other allergic rhinitis

16.6

6.1

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

16.6

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3013115) Eosinophils [#/volume] in Blood

378

2.56

4.47

9.4

5.6

0.2

e9/l

0.40

343

(3006315) Basophils [#/volume] in Blood

371

2.30

3.66

8.9

5.2

0.0

e9/l

0.72

334

(3001604) Monocytes [#/volume] in Blood

371

2.30

3.66

8.6

5.2

0.6

0.5

e9/l

1.42

330

(3019198) Lymphocytes [#/volume] in Blood

378

2.23

3.41

9.0

5.3

2.1

2.0

e9/l

0.48

342

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

5.04

2.99

2.4

1.9

—

(3000494) Fungus identified in Specimen by Culture

2.41

2.43

2.1

1.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

4.50

2.19

1.0

—

(42870588) Differential panel, method unspecified - Blood

231

1.83

1.98

8.9

5.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

198

1.85

1.94

4.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

325

1.75

1.87

7.6

6.2

1.2

mmol/l

0.67

279

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

3.30

1.69

3.2

2.1

10.4

8.9

mg/l

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

124

1.90

1.65

1.5

1.4

7.1

19.5

u/ml

0.84

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.46

1.54

1.0

1.6

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

129

1.81

1.46

1.5

1.3

13.0

26.4

iu/ml

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.84

1.46

2.5

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.84

1.46

3.2

1.5

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

3.24

1.45

1.0

1.8

—

2.6

—

(3022313) Gas panel - Capillary blood

2.49

1.26

13.8

2.4

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.27

1.25

10.8

2.2

1.3

1.1

mmol/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.21

1.22

1.0

1.1

—

(1761868) Lipid panel - Serum or Plasma

335

0.62

1.20

2.8

2.7

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.15

1.18

10.7

2.2

5.9

5.0

kpa

—

(3011288) Drugs identified in Urine by Screen method

2.58

1.16

1.4

1.1

—

(3022145) Colonoscopy Study observation

1.82

1.16

1.2

1.3

—

(3042936) Bacteria identified in Isolate by Culture

1.79

1.16

1.6

2.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

106

1.74

1.12

2.6

1.8

—

(4010399)

2.04

1.11

1.3

—

(3019060) Gas panel - Arterial blood

2.01

1.06

3.3

4.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

490

1.50

1.04

6.4

3.6

—

(3000492) Spirometry study

1.85

1.02

2.2

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.78

0.97

2.6

1.5

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

137

1.59

0.94

3.9

4.1

159.8

173.9

ng/l

0.03

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.99

0.91

2.1

1.4

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

156

1.54

0.90

1.4

1.2

0.5

1.4

u/ml

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.81

0.85

1.4

1.2

—

(40761511) CBC panel - Blood by Automated count

813

0.63

0.83

18.8

12.0

—

(3003694) ABO and Rh group [Type] in Blood

216

0.63

0.82

1.5

1.4

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.80

0.0

1.0

—

(3010813) Leukocytes [#/volume] in Blood

867

0.56

0.78

27.9

18.5

6.9

6.7

e9/l

0.56

844

(3024731) MCV [Entitic volume]

866

0.58

0.77

27.6

18.3

91.3

90.8

0.37

854

(3000963) Hemoglobin [Mass/volume] in Blood

866

0.58

0.77

27.9

18.5

136.9

137.5

g/l

0.14

855

(3026361) Erythrocytes [#/volume] in Blood

866

0.58

0.77

27.7

18.3

4.5

4.6

e12/l

0.06

842

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.24

0.77

1.2

0.2

0.3

g/l

—

(3035941) MCH [Entitic mass]

865

0.59

0.76

27.6

18.3

30.3

30.4

0.10

853

(3007461) Platelets [#/volume] in Blood

865

0.59

0.76

28.0

18.4

254.6

250.5

e9/l

0.28

843

(3018418) pH of Serum or Plasma

199

1.43

0.73

2.9

3.8

7.4

—

(3044640) Blood type and Crossmatch panel - Blood

209

1.41

0.72

2.4

2.1

—

(3025941) Bacteria identified in Stool by Culture

1.76

0.72

1.1

1.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.76

0.72

2.7

2.5

26.1

24.6

mmol/l

—

(3023368) Bacteria identified in Blood by Culture

182

1.43

0.71

3.6

3.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.64

0.67

1.4

2.8

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

288

1.35

0.64

3.4

2.3

76.6

77.3

nmol/l

0.05

267

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.61

0.0

1.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

271

1.34

0.61

2.2

1.8

96.4

99.0

pmol/l

0.15

126

(3032080) INR in Blood by Coagulation assay

282

1.33

0.58

16.6

7.6

1.2

1.1

inr

0.29

(40758558) Short blood count panel - Blood

181

1.36

0.55

9.6

7.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

146

1.38

0.52

1.8

1.3

1.9

2.6

g/l

0.88

(3001019) Free T4 and TSH panel - Serum or Plasma

1.60

0.50

1.7

1.8

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

789

0.73

0.46

4.4

5.0

2.7

2.8

mmol/l

0.24

739

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.64

0.45

1.3

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.62

0.45

4.0

7.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.65

0.44

2.4

1.3

—

(4035726)

1.44

0.43

1.1

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

142

1.33

0.42

2.4

3.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.50

0.41

2.8

1.5

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

0.40

0.0

1.7

—

113.0

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.40

0.0

1.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.40

0.0

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

111

0.69

0.40

1.7

1.5

—

(3022948) Iron [Moles/volume] in Serum or Plasma

1.36

0.38

2.5

2.3

12.1

14.3

umol/l

0.54

(3002385) Erythrocyte distribution width [Ratio]

652

0.81

0.37

19.8

15.2

13.9

13.6

0.70

645

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

496

1.21

0.35

3.0

3.2

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.68

0.35

8.0

4.5

2.9

91.8

ug/l

—

(40768797) Stomach Pathology biopsy report

101

1.33

0.34

1.1

1.2

—

(40761535) Cells panel - Urine sediment

1.37

0.32

5.7

2.8

—

(3035350) Ketones [Presence] in Urine by Test strip

350

1.20

0.32

3.8

3.2

0.0

estimate

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

253

1.21

0.31

2.9

3.2

25.9

32.2

u/l

1.09

240

(3021589) Normoblasts [#/volume] in Blood

342

1.19

0.30

9.8

9.6

0.0

e9/l

0.32

286

(3023103) Potassium [Moles/volume] in Serum or Plasma

788

0.80

0.28

18.5

13.8

4.0

mmol/l

0.10

768

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

564

1.18

0.27

4.6

3.9

15.0

14.8

pmol/l

0.23

522

(40768804) Tissue Pathology biopsy report

286

1.18

0.27

2.0

1.8

—

(3021601) Nitrite [Presence] in Urine by Test strip

356

1.17

0.25

5.6

4.3

0.0

estimate

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

198

0.83

0.23

4.2

4.0

16.7

21.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

289

1.16

0.23

3.8

3.1

92.7

27.2

ng/l

0.53

194

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

718

0.84

0.23

14.6

11.5

83.6

ml/min/173m2

0.01

585

(3012516) Albumin [Mass/volume] in Urine

193

1.18

0.22

3.6

3.4

70.2

52.0

mg/l

0.12

129

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.5

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.21

0.0

1.5

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.3

—

(3024928) Oxygen saturation in Venous blood

0.00

0.21

0.0

1.8

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.4

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

697

0.86

0.21

5.5

4.6

1.7

1.9

mu/l

0.74

645

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.3

—

(3006184) Hemoglobin [Mass/volume] in Capillary blood

0.00

0.21

0.0

2.2

—

129.0

—

(3015736) pH of Urine

272

1.15

0.20

3.0

2.9

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

783

0.83

0.20

18.6

13.8

140.1

139.7

mmol/l

1.24

764

(3009261) Glucose [Presence] in Urine by Test strip

361

1.14

0.20

3.8

3.2

0.0

estimate

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

224

1.16

0.20

2.3

2.1

97.0

271.9

u/l

1.39

212

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.26

0.19

1.7

329.0

347.7

nmol/l

—

(3013512) EKG study

225

0.86

0.19

4.6

3.2

—

(3019225) pH of Specimen

1.20

0.18

10.4

4.7

—

(3009542) Hematocrit [Volume Fraction] of Blood

704

0.87

0.18

17.0

12.9

39.2

40.6

0.43

529

(3002256) Pathology report gross observation

1.25

0.18

1.3

1.2

—

(3026008) Bacteria identified in Urine by Culture

192

0.86

0.16

3.4

2.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.17

0.16

2.7

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.14

0.16

2.7

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

331

0.90

0.13

4.5

4.2

—

(3000850) Epithelial cells [#/volume] in Urine

143

1.14

0.12

2.8

2.2

3.4

3.5

e6/l

0.04

126

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

708

0.90

0.11

6.1

5.4

41.7

39.6

mmol/mol

0.71

667

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

155

1.12

0.10

3.1

2.1

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.06

0.09

1.5

1.2

—

32.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.10

0.08

1.9

1.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

153

0.90

0.08

1.1

1.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.07

0.07

2.2

2.3

—

(21494755) Public health laboratory ask at order entry panel

0.85

0.07

1.3

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.85

0.07

1.6

1.5

—

(3044889) 12 lead EKG panel

534

0.94

0.06

4.4

3.8

—

(3026782) Osmolality of Urine

130

0.91

0.05

1.9

2.3

536.0

563.2

mosm/kgh2o

0.15

110

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

780

1.09

0.05

18.8

11.9

21.5

22.0

mg/l

0.06

612

(3041096) Erythrocytes [Presence] in Urine by Automated

221

1.05

0.03

4.6

2.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

108

0.92

0.03

1.1

1.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

178

0.94

0.02

1.6

1.5

1.1

1.0

mg/l

0.08

150

(3018095) Leukocytes [#/volume] in Urine

237

0.96

0.01

4.1

3.3

33.4

77.9

e6/l

0.47

173

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

254

1.03

0.00

4.8

4.4

4.8

2.0

ug/l

0.41

232

(3020564) Creatinine [Moles/volume] in Serum or Plasma

812

0.98

0.00

19.9

14.5

84.2

75.5

umol/l

0.80

812

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

243

0.98

0.00

4.4

2.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

285

1.03

0.00

4.5

3.2

—

(36304419) Bacteria [Presence] in Urine

185

0.97

0.00

3.0

2.5

—

(3029937) Albumin [Presence] in Urine by Test strip

194

0.97

0.00

4.1

3.4

0.0

estimate

—

(3020682) Albumin/Creatinine [Ratio] in Urine

206

1.03

0.00

5.7

4.1

8.6

8.0

mg/mmol

0.03

131

(3009508) Creatinine [Moles/volume] in Urine

211

0.99

0.00

3.9

3.1

7.7

8.1

mmol/l

0.19

178

(46235355) HIV 1 and 2 tests - Meaningful Use set

131

0.99

0.00

1.8

1.9

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

2.1

—

(3017704) Immunofixation for Urine

0.00

0.0

1.0

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.0

1.4

—

66.7

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

11.8

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.0

—

11.8

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.4

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3022192) Triglyceride [Mass/volume] in Serum or Plasma

0.00

0.0

2.8

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

8.6

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.2

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.3

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.4

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

2.3

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

2.1

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.1

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.01

0.00

1.8

2.1

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

245.9

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

9.7

—

(40761536) Microorganisms panel - Urine sediment

0.87

0.00

3.7

3.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

2.0

—

32.3

—

(4211845)

0.00

0.0

1.3

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.2

—

99.5

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

1.0

—

66.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

1.7

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.2

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

49.3

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.0

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3022621) pH of Urine by Test strip

1.02

0.00

3.0

2.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.3

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.5

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

3.9

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.1

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.6

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.5

—

(36660697) Celiac disease serology panel - Serum

0.98

0.00

1.4

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

1.5

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

4.9

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

5.8

—

142.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint J10_AIRWDISDUST and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have J10_AIRWDISDUST.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: J10_AIRWDISDUST – Airway disease due to specific organic dust

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Airway disease due to specific organic dust

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints